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These are the user uploaded subtitles that are being translated: 1 00:00:04,917 --> 00:00:06,745 Those are yours. 2 00:00:06,789 --> 00:00:09,444 We bought them together. 3 00:00:09,487 --> 00:00:12,012 Because you "found the pattern soothing." 4 00:00:17,017 --> 00:00:20,455 ♪♪ 5 00:00:20,498 --> 00:00:22,848 I'm gonna miss you, Shaun. 6 00:00:22,892 --> 00:00:24,502 I love Carly. 7 00:00:26,548 --> 00:00:28,202 And that's great. 8 00:00:28,245 --> 00:00:30,291 I am so happy for you. 9 00:00:30,334 --> 00:00:33,555 Now you can hang the toilet paper incorrectly 10 00:00:33,598 --> 00:00:35,557 anytime you want. 11 00:00:35,600 --> 00:00:36,993 And Carly and I can go back 12 00:00:37,037 --> 00:00:38,342 to the way things were before our fight. 13 00:00:40,649 --> 00:00:43,434 Well, sometimes couples need a little time to recover. 14 00:00:43,478 --> 00:00:44,827 We won't. 15 00:00:44,870 --> 00:00:47,482 Carly asked for you to move out. 16 00:00:47,525 --> 00:00:49,527 You aremoving out. 17 00:00:49,571 --> 00:00:52,617 ♪♪ 18 00:00:52,661 --> 00:00:55,272 How many kidneys do I need in my body to attend prom? 19 00:00:55,316 --> 00:00:56,404 [ Chuckling ] Ryan... 20 00:00:56,447 --> 00:00:57,840 Even if the surgery removes my kidney, 21 00:00:57,883 --> 00:00:59,320 it'll be laparoscopic, 22 00:00:59,363 --> 00:01:02,497 so my inpatient time will be seven days, tops. 23 00:01:02,540 --> 00:01:04,716 And then three more days of rest at home. 24 00:01:04,760 --> 00:01:06,153 I can take my girlfriend to prom, right? 25 00:01:07,806 --> 00:01:09,156 That's not a purely medical decision. 26 00:01:09,199 --> 00:01:11,114 I have to draw some blood. 27 00:01:11,158 --> 00:01:12,811 What are the chances Dr. Melendez might be able 28 00:01:12,855 --> 00:01:14,770 to remove the tumor but spare Ryan's kidney? 29 00:01:14,813 --> 00:01:16,598 Well, the MRI will let us know 30 00:01:16,641 --> 00:01:18,513 how much the chemo shrunk the tumor, 31 00:01:18,556 --> 00:01:20,993 but you shouldn't count on it. 32 00:01:21,037 --> 00:01:23,866 One chili burger, extra mustard, extra pickles. 33 00:01:23,909 --> 00:01:25,998 Hi. Morning, Mr. Cooper. 34 00:01:26,042 --> 00:01:27,739 I'm not sure he can have that with his surgery -- 35 00:01:27,783 --> 00:01:29,350 Oh, he's fine until about 6:30 tonight. 36 00:01:30,307 --> 00:01:31,787 Claire: I know you. 37 00:01:31,830 --> 00:01:34,311 Angie...Valens. 38 00:01:34,355 --> 00:01:36,096 I helped put in your chemo port. 39 00:01:36,139 --> 00:01:38,489 I owe you a big thank-you. [ Chuckles ] 40 00:01:38,533 --> 00:01:40,578 We met in chemo. 41 00:01:40,622 --> 00:01:42,406 They should put us in a public service announcement or something. 42 00:01:42,450 --> 00:01:44,582 Yeah -- "I lost a tumor and gained a boyfriend. 43 00:01:44,626 --> 00:01:45,496 Thanks, chemo." 44 00:01:45,540 --> 00:01:46,541 [ Laughter ] 45 00:01:50,110 --> 00:01:51,676 James McDougall? 46 00:01:51,720 --> 00:01:53,069 That's who we're here for, too. 47 00:01:53,113 --> 00:01:55,593 All of you can head over to Bay 4. 48 00:01:55,637 --> 00:01:57,595 Guy saw me six months ago for a stress fracture. 49 00:01:57,639 --> 00:01:59,989 He's a lunatic ultra-marathoner. 50 00:02:00,032 --> 00:02:01,556 I just hope he didn't go too hard too soon 51 00:02:01,599 --> 00:02:02,774 and break it again. 52 00:02:05,821 --> 00:02:07,344 [ Breathes shakily ] 53 00:02:09,172 --> 00:02:11,348 He didn't break it again. 54 00:02:11,392 --> 00:02:15,091 ♪♪ 55 00:02:15,135 --> 00:02:17,746 -- Captions by VITAC -- 56 00:02:17,789 --> 00:02:25,710 ♪♪ 57 00:02:25,754 --> 00:02:28,148 Lim: Your GP was right to start you on ketoprofen for the swelling, 58 00:02:28,191 --> 00:02:30,150 but clearly, it isn't working. 59 00:02:30,193 --> 00:02:31,803 That's why Drs. Murphy and Reznick 60 00:02:31,847 --> 00:02:33,805 are going to block off some of your lymphatic channels. 61 00:02:33,849 --> 00:02:35,851 It should reduce production. 62 00:02:35,894 --> 00:02:37,940 The more pressing concern is why. 63 00:02:37,983 --> 00:02:39,898 Have you ever had surgery on your lymph nodes? 64 00:02:41,509 --> 00:02:43,902 What about cancer or radiation treatment? 65 00:02:43,946 --> 00:02:45,643 No. Physically, I've always been healthy. 66 00:02:45,687 --> 00:02:47,515 Physically? 67 00:02:47,558 --> 00:02:49,169 I was diagnosed with Persistent Depressive Disorder 68 00:02:49,212 --> 00:02:51,432 when I was 16. 69 00:02:51,475 --> 00:02:54,348 That's why you got to get me back out on the road, Doc. 70 00:02:54,391 --> 00:02:56,393 Are antidepressants not effective for you? 71 00:02:56,437 --> 00:02:58,134 I mean, they help. 72 00:02:58,178 --> 00:03:00,963 But running really is key. 73 00:03:01,006 --> 00:03:03,835 Saved my marriage and -- and my life. 74 00:03:03,879 --> 00:03:06,229 Lymphedema can be caused by an infection. 75 00:03:06,273 --> 00:03:08,579 He doesn't have a fever. 76 00:03:08,623 --> 00:03:09,841 Ketoprofen can suppress fevers. 77 00:03:09,885 --> 00:03:11,365 Let's get some cultures 78 00:03:11,408 --> 00:03:13,236 and start him on broad-spec antibiotics. 79 00:03:13,280 --> 00:03:17,632 ♪♪ 80 00:03:17,675 --> 00:03:21,157 As requested, your restock on enemas. 81 00:03:21,201 --> 00:03:22,419 Nice cover. 82 00:03:24,029 --> 00:03:25,292 How've you been feeling? 83 00:03:25,335 --> 00:03:26,858 The methotrexate is working great. 84 00:03:26,902 --> 00:03:29,209 No pain, no redness. 85 00:03:29,252 --> 00:03:31,036 Stiffness, flu-like symptoms? 86 00:03:31,080 --> 00:03:32,429 No. All good. 87 00:03:32,473 --> 00:03:34,214 [ Faucet handles squeak ] 88 00:03:34,257 --> 00:03:35,954 How long are you planning to hide out 89 00:03:35,998 --> 00:03:38,218 doing RA exams and clipping diabetics' toenails? 90 00:03:39,828 --> 00:03:42,178 Dizziness, headaches, nausea? 91 00:03:42,222 --> 00:03:44,659 I -- Sometimes I'm a little queasy after I eat. 92 00:03:46,226 --> 00:03:47,879 You had to love neurosurgery. 93 00:03:49,577 --> 00:03:51,231 How about we try to get you a medication 94 00:03:51,274 --> 00:03:53,102 that doesn't irritate your stomach? 95 00:03:53,145 --> 00:03:55,104 No. My hands feel great. That's all I care about. 96 00:03:56,714 --> 00:03:59,935 You used to open up skulls and poke around people's brains. 97 00:03:59,978 --> 00:04:01,893 There's no way thisfulfills you. 98 00:04:01,937 --> 00:04:04,156 I enjoy it. 99 00:04:04,200 --> 00:04:06,811 Or, rather, I usuallyenjoy it. 100 00:04:06,855 --> 00:04:08,770 [ Inhales sharply ] 101 00:04:08,813 --> 00:04:10,075 I'll let you get back to it. 102 00:04:12,469 --> 00:04:14,906 Maybe someone out there needs an enema. 103 00:04:14,950 --> 00:04:17,344 [ Door closes ] 104 00:04:17,387 --> 00:04:19,868 [ MRI machine humming ] 105 00:04:19,911 --> 00:04:20,956 Got a measurement on the Wilms tumor? 106 00:04:20,999 --> 00:04:23,437 Mm, not quite there yet. 107 00:04:23,480 --> 00:04:26,396 You mentioned 7 centimeters as our limit 108 00:04:26,440 --> 00:04:27,658 to doing this laparoscopically. 109 00:04:27,702 --> 00:04:29,878 What if we pushed it to 7.2? 110 00:04:29,921 --> 00:04:32,184 Would speed up recovery. 111 00:04:32,228 --> 00:04:33,664 By a few days. 112 00:04:35,144 --> 00:04:36,580 Forget I brought it up. 113 00:04:36,624 --> 00:04:39,409 Ryan wanting to take his girlfriend to prom 114 00:04:39,453 --> 00:04:42,673 should not factor into our surgical plan. 115 00:04:42,717 --> 00:04:43,979 Is he nuts about her? 116 00:04:44,022 --> 00:04:46,938 Ohh. Crazy, head over heels in love. 117 00:04:46,982 --> 00:04:48,157 They both are. 118 00:04:48,200 --> 00:04:49,332 Idiots. 119 00:04:49,376 --> 00:04:51,378 [ Chuckles ] 120 00:04:51,421 --> 00:04:54,598 I wouldn't mind being an idiot like that again. 121 00:04:54,642 --> 00:04:57,775 Though, I'm not sure I ever felt thatway -- 122 00:04:57,819 --> 00:04:59,690 totally happy. 123 00:04:59,734 --> 00:05:00,648 So therapy's going well? 124 00:05:00,691 --> 00:05:02,606 [ Chuckles ] 125 00:05:02,650 --> 00:05:04,216 No metastasis in the lungs. 126 00:05:06,001 --> 00:05:07,481 Look at that. 127 00:05:07,524 --> 00:05:13,225 ♪♪ 128 00:05:13,269 --> 00:05:14,662 Your tumor is gone. 129 00:05:14,705 --> 00:05:16,359 [ Gasps ] 130 00:05:16,403 --> 00:05:17,534 Gone? 131 00:05:19,884 --> 00:05:21,190 How's that possible?[ Chuckles ] 132 00:05:21,233 --> 00:05:23,932 The chemotherapy worked better than we expected. 133 00:05:23,975 --> 00:05:26,804 Wait, like, no tumor? Zero? 134 00:05:26,848 --> 00:05:27,979 No need for surgery whatsoever? 135 00:05:28,023 --> 00:05:29,111 Claire: That is right. 136 00:05:29,154 --> 00:05:30,808 These are discharge forms. 137 00:05:30,852 --> 00:05:32,593 [ Laughs ] 138 00:05:32,636 --> 00:05:34,072 [ Squeals, giggles ] 139 00:05:34,116 --> 00:05:36,379 Both of my kidneys are taking you to prom! 140 00:05:36,423 --> 00:05:37,772 Aah! Hell, yeah, we are! 141 00:05:37,815 --> 00:05:39,513 [ Laughs ] 142 00:05:39,556 --> 00:05:40,557 [ Laughs ] 143 00:05:42,298 --> 00:05:43,517 [ Clears throat ] 144 00:05:44,953 --> 00:05:46,433 Angie? 145 00:05:48,478 --> 00:05:49,566 Angie! 146 00:05:49,610 --> 00:05:50,741 She's having a seizure! 147 00:05:50,785 --> 00:05:52,569 [ Grunting ] 148 00:05:52,613 --> 00:05:54,832 2 milligrams of lorazepam and portable oxygen, stat. 149 00:05:54,876 --> 00:05:57,008 Let's get that under her head. 150 00:05:57,052 --> 00:05:59,489 [ Alarm blaring ] 151 00:05:59,533 --> 00:06:00,360 His lungs are filled with fluid. 152 00:06:02,710 --> 00:06:05,277 I need a chest X-ray and a bedside ultrasound. 153 00:06:05,321 --> 00:06:07,367 And page Dr. Reznick. 154 00:06:09,194 --> 00:06:10,848 [ Coughing ] 155 00:06:10,892 --> 00:06:13,155 [ Pager beeping ] 156 00:06:13,198 --> 00:06:17,420 ♪♪ 157 00:06:17,464 --> 00:06:18,465 [ Beeping continues ] 158 00:06:21,642 --> 00:06:22,817 Imaging has confirmed 159 00:06:22,860 --> 00:06:24,862 a reoccurrence of your brain tumor. 160 00:06:24,906 --> 00:06:26,386 What stage? 161 00:06:27,648 --> 00:06:28,562 3. 162 00:06:30,651 --> 00:06:34,089 The best approach is surgery -- a wide resection of the tumor, 163 00:06:34,132 --> 00:06:36,221 followed by radiation and chemo to encourage full remission. 164 00:06:37,875 --> 00:06:40,704 Sounds like a fun couple months. 165 00:06:40,748 --> 00:06:44,012 Full recovery will probably take closer to eight. 166 00:06:45,970 --> 00:06:46,667 [ Sighs ] 167 00:06:49,452 --> 00:06:51,323 We can get through this, baby, just like last time. 168 00:06:53,935 --> 00:06:56,024 W-When will the surgery be? 169 00:06:56,067 --> 00:06:57,895 We need to do some additional imaging, 170 00:06:57,939 --> 00:06:59,549 and I'd like to consult a colleague 171 00:06:59,593 --> 00:07:00,811 about the best surgical approach. 172 00:07:00,855 --> 00:07:01,682 That'll take a few days. 173 00:07:03,771 --> 00:07:04,554 Take your time. 174 00:07:06,861 --> 00:07:08,079 Prom? 175 00:07:09,516 --> 00:07:10,734 [ Chuckling ] Yeah. 176 00:07:10,778 --> 00:07:12,780 Now that Ryan can go, I haveto go. 177 00:07:12,823 --> 00:07:15,870 Honey. This is your health we're talking about. 178 00:07:15,913 --> 00:07:18,568 [ Voice breaking ] Mom, please. 179 00:07:18,612 --> 00:07:22,137 I just want to do this one thing like a normal kid. 180 00:07:22,180 --> 00:07:23,965 [ Sighs ] 181 00:07:24,008 --> 00:07:25,662 Can you tell her it's okay? 182 00:07:27,229 --> 00:07:28,448 Park: We can't. 183 00:07:28,491 --> 00:07:29,971 Until we remove your tumor, you're at risk 184 00:07:30,014 --> 00:07:31,276 of potentially fatal seizures. 185 00:07:34,236 --> 00:07:35,498 After you're recovered, 186 00:07:35,542 --> 00:07:37,326 you and Ryan can get all dressed up, 187 00:07:37,369 --> 00:07:38,545 and we'll go have dinner at the Grandview. 188 00:07:38,588 --> 00:07:39,589 Okay? 189 00:07:45,943 --> 00:07:48,163 Prom sucks. 190 00:07:48,206 --> 00:07:49,947 My buddy had a fake ID. 191 00:07:49,991 --> 00:07:51,732 I got so drunk in the limo that I passed out 192 00:07:51,775 --> 00:07:54,299 and never made it into the dance. 193 00:07:54,343 --> 00:07:56,780 Maybe that wasn't everybody's experience. 194 00:07:56,824 --> 00:07:58,652 I was prom king. My date was queen. 195 00:08:03,744 --> 00:08:05,136 I had the dress, I had the date, 196 00:08:05,180 --> 00:08:06,964 I had the mom who got arrested. 197 00:08:07,008 --> 00:08:08,966 Spent the night picking her up from the drunk tank. 198 00:08:09,010 --> 00:08:10,141 Did you see Park while you were there? 199 00:08:10,185 --> 00:08:12,013 [ Laughs ] 200 00:08:12,056 --> 00:08:14,189 Go to scheduling, get Angie's surgery set for Friday -- 201 00:08:14,232 --> 00:08:15,712 with the best neurosurgery OR nurses. 202 00:08:18,628 --> 00:08:20,151 Let's go see Glassman. 203 00:08:20,195 --> 00:08:22,197 Andrews: Now I'm identifying 204 00:08:22,240 --> 00:08:23,894 the submillimeter lymphatic vessels. 205 00:08:23,938 --> 00:08:28,029 I need an 11-0 micro suture and a 70 micron needle. 206 00:08:28,072 --> 00:08:30,858 Instead of harvesting nodes to this area, 207 00:08:30,901 --> 00:08:33,295 could we redirect lymphatics away from his lymph system? 208 00:08:33,338 --> 00:08:34,731 We could. 209 00:08:34,775 --> 00:08:36,907 If you identify an appropriate vessel, 210 00:08:36,951 --> 00:08:38,648 you can make the connection. 211 00:08:38,692 --> 00:08:40,955 Lim: We're clearly not dealing with an infection. 212 00:08:40,998 --> 00:08:43,087 There must be a blockage somewhere in his lymph system. 213 00:08:43,131 --> 00:08:45,133 Most likely cancer. 214 00:08:45,176 --> 00:08:48,615 His CBC didn't show any abnormal cells. 215 00:08:48,658 --> 00:08:50,704 Lymphoma doesn't always show up. 216 00:08:50,747 --> 00:08:53,097 We need to run cytology on his lymphatic fluid. 217 00:08:59,103 --> 00:09:01,497 It's either gonna be nasty or verynasty, 218 00:09:01,541 --> 00:09:05,675 depending upon how it attaches to the thalamus and fornix. 219 00:09:05,719 --> 00:09:09,636 Which no imaging or testing can possibly determine. 220 00:09:09,679 --> 00:09:11,899 So, our options are? 221 00:09:11,942 --> 00:09:14,597 Between an endoscopic approach or an open anterior one. 222 00:09:14,641 --> 00:09:16,425 That is correct. 223 00:09:18,906 --> 00:09:23,432 I'd run a stereotactic MRI with fiducials and DTI 224 00:09:23,475 --> 00:09:26,000 to gauge how close the white matter tracts actually are. 225 00:09:27,436 --> 00:09:28,568 You should scrub in. 226 00:09:28,611 --> 00:09:30,308 [ Chuckles ] 227 00:09:30,352 --> 00:09:31,832 Another doctor can cover the clinic. 228 00:09:33,573 --> 00:09:36,401 I haven't been in an OR in over a year, 229 00:09:36,445 --> 00:09:38,578 and then, as a patient. 230 00:09:38,621 --> 00:09:40,667 I'm not asking you to cut. 231 00:09:40,710 --> 00:09:42,799 But it'd be a huge value to have you there. 232 00:09:42,843 --> 00:09:44,932 [ Chuckles softly ] 233 00:09:44,975 --> 00:09:46,455 I appreciate that. 234 00:09:46,498 --> 00:09:48,065 I'll consider it. 235 00:09:48,109 --> 00:09:55,029 ♪♪ 236 00:09:55,072 --> 00:09:57,161 [ Door opens ] 237 00:09:57,205 --> 00:09:58,815 [ Door closes ] 238 00:10:02,689 --> 00:10:05,605 Hello. We need to run cytology on this lymphatic fluid. 239 00:10:05,648 --> 00:10:07,215 I would be happy to. 240 00:10:11,349 --> 00:10:12,655 Lea moved out this morning. 241 00:10:15,876 --> 00:10:16,964 Thank you. 242 00:10:17,007 --> 00:10:18,139 You're welcome. 243 00:10:18,182 --> 00:10:19,967 Can you come over tonight? 244 00:10:20,010 --> 00:10:21,621 Uh, that probably won't work -- 245 00:10:21,664 --> 00:10:23,057 Or we could go to your apartment? 246 00:10:24,667 --> 00:10:25,712 I can't. 247 00:10:28,149 --> 00:10:30,847 Lea said that it might take time 248 00:10:30,891 --> 00:10:32,936 for us to recover from our fight. 249 00:10:32,980 --> 00:10:34,546 But I told her that we were okay. 250 00:10:34,590 --> 00:10:36,461 We are. 251 00:10:36,505 --> 00:10:38,507 I made plans tonight. 252 00:10:38,550 --> 00:10:41,989 To hang out with a friend who just got fired. 253 00:10:42,032 --> 00:10:44,295 But I would love to come over tomorrownight. 254 00:10:44,339 --> 00:10:46,950 Okay. 255 00:10:46,994 --> 00:10:49,213 I'll put a rush on this test, too. 256 00:10:49,257 --> 00:10:56,264 ♪♪ 257 00:10:56,307 --> 00:10:59,310 Your lymphovenous anastomosis technique -- 258 00:10:59,354 --> 00:11:01,008 I was impressed. 259 00:11:01,051 --> 00:11:02,792 It's a little early in the morning 260 00:11:02,836 --> 00:11:04,489 to be sucking up, Reznick. 261 00:11:04,533 --> 00:11:06,753 Not for me. I like to get a jump on things. 262 00:11:06,796 --> 00:11:08,842 I'm fascinated by the way you use plastic procedures, 263 00:11:08,885 --> 00:11:11,888 like microsurgery, in other surgical specialties. 264 00:11:11,932 --> 00:11:14,282 I thought it might make an interesting topic for a paper. 265 00:11:14,325 --> 00:11:15,936 Want to write it with me? 266 00:11:17,111 --> 00:11:18,721 Yes. 267 00:11:18,765 --> 00:11:19,940 Let's talk and eat. 268 00:11:22,725 --> 00:11:24,466 That's not breakfast. 269 00:11:25,772 --> 00:11:27,599 I'm buying. 270 00:11:27,643 --> 00:11:29,558 What publications do you want to target? 271 00:11:29,601 --> 00:11:30,951 [ Sighs ] 272 00:11:32,387 --> 00:11:34,781 Last time, Angie had bad post-op vomiting. 273 00:11:34,824 --> 00:11:35,869 Of course. I'll make note of it --Excuse me. 274 00:11:37,827 --> 00:11:40,787 She's asleep. She needs her rest. 275 00:11:40,830 --> 00:11:42,179 I'll wait out here until she's awake. 276 00:11:42,223 --> 00:11:44,355 Ryan, your immune system is weak. 277 00:11:44,399 --> 00:11:45,966 It would be so easy for you to pick up a bug 278 00:11:46,009 --> 00:11:47,576 and pass it to Angie. 279 00:11:47,619 --> 00:11:49,317 I haven't been around anyone but my dad. I swear. 280 00:11:49,360 --> 00:11:50,710 He could wear a mask. 281 00:11:54,975 --> 00:11:56,454 After Angie's surgery, 282 00:11:56,498 --> 00:11:58,587 we'll see about arranging a visit. 283 00:11:58,630 --> 00:11:59,719 Please tell her Ryan came by. 284 00:12:02,983 --> 00:12:05,594 I'm sorry if I overstepped. 285 00:12:05,637 --> 00:12:07,639 I'd like to change Angie's status 286 00:12:07,683 --> 00:12:09,163 to "No visitors" on her chart. 287 00:12:09,206 --> 00:12:10,077 Yeah. 288 00:12:10,120 --> 00:12:17,780 ♪♪ 289 00:12:17,824 --> 00:12:19,173 Please take Mr. McDougall to his room. 290 00:12:19,216 --> 00:12:20,696 I'll be there in a moment. 291 00:12:22,785 --> 00:12:23,873 Is that James McDougall? 292 00:12:24,831 --> 00:12:26,180 And the woman with him? 293 00:12:26,223 --> 00:12:27,355 His wife. 294 00:12:27,398 --> 00:12:29,096 Is it cancer? [ Sighs ] 295 00:12:29,139 --> 00:12:30,097 No -- worse. 296 00:12:31,663 --> 00:12:35,102 His lymphedema is caused by a genetic mutation. 297 00:12:35,145 --> 00:12:37,104 If you don't find a medication he responds to, 298 00:12:37,147 --> 00:12:39,497 he'll drown from the inside. 299 00:12:39,541 --> 00:12:40,672 ♪♪ 300 00:12:44,024 --> 00:12:46,635 The mutation is on James' ARAF gene -- 301 00:12:46,678 --> 00:12:48,071 it makes an enzyme called kinase, 302 00:12:48,115 --> 00:12:50,117 which can cause cells to overproliferate. 303 00:12:50,160 --> 00:12:51,248 It's a genetic condition. 304 00:12:54,556 --> 00:12:56,601 What set it off now? 305 00:12:56,645 --> 00:12:58,038 Probably the stress fracture. 306 00:12:58,081 --> 00:12:59,735 Sent his immune system into overdrive, 307 00:12:59,779 --> 00:13:01,998 which fired up his lymphatic system. 308 00:13:02,042 --> 00:13:04,044 What treatment protocol targets this mutation? 309 00:13:04,087 --> 00:13:05,741 An MEK inhibitor. 310 00:13:05,785 --> 00:13:07,656 The problem is, which one? 311 00:13:07,699 --> 00:13:11,355 There are 41 possibilities, each with different side effects. 312 00:13:11,399 --> 00:13:13,009 Good luck. 313 00:13:13,053 --> 00:13:15,055 Well, I was hoping you could stay. 314 00:13:18,406 --> 00:13:20,408 Okay. Sure. 315 00:13:22,062 --> 00:13:23,280 [ MRI machine humming ] 316 00:13:23,324 --> 00:13:26,022 We need you to stay completely still. 317 00:13:26,066 --> 00:13:27,067 Not a problem. 318 00:13:29,417 --> 00:13:31,506 You okay? 319 00:13:31,549 --> 00:13:33,638 Ryan totally bailed. 320 00:13:33,682 --> 00:13:34,857 He hasn't come back to see me. 321 00:13:38,165 --> 00:13:40,123 If you tell her that her mom said he couldn't visit, 322 00:13:40,167 --> 00:13:41,646 she'll be pissed at her mom. 323 00:13:41,690 --> 00:13:42,952 How's that gonna help? 324 00:13:45,781 --> 00:13:48,436 He's probably... busy catching up in school. 325 00:13:51,134 --> 00:13:53,267 We had a pact -- 326 00:13:53,310 --> 00:13:56,923 as long as we were together, cancer wasn't gonna beat us. 327 00:13:56,966 --> 00:13:58,707 He broke it. 328 00:13:58,750 --> 00:14:00,274 Cancer wins. 329 00:14:00,317 --> 00:14:05,453 ♪♪ 330 00:14:05,496 --> 00:14:07,194 Do you mind finishing? 331 00:14:07,237 --> 00:14:09,283 [ Sighs ] 332 00:14:09,326 --> 00:14:15,942 ♪♪ 333 00:14:19,206 --> 00:14:20,337 Imaging finished? 334 00:14:20,381 --> 00:14:21,948 Not quite. 335 00:14:21,991 --> 00:14:25,690 Mrs. Valens, Angie would really like to see Ryan. 336 00:14:25,734 --> 00:14:27,214 I know you're concerned about infection, 337 00:14:27,257 --> 00:14:28,911 but there is minimal risk. 338 00:14:28,955 --> 00:14:31,871 Actually -- Actually, none, if they do a video chat. 339 00:14:31,914 --> 00:14:34,090 Interesting idea. 340 00:14:34,134 --> 00:14:35,309 I'll think about it. 341 00:14:38,138 --> 00:14:40,270 Angie's depressed. 342 00:14:40,314 --> 00:14:42,751 And studies have shown that that can have a negative impact 343 00:14:42,794 --> 00:14:44,622 on her surgical outcome. 344 00:14:44,666 --> 00:14:47,190 [ Laughs ] 345 00:14:47,234 --> 00:14:50,628 Ryan doesn't always improve Angie's mood. 346 00:14:50,672 --> 00:14:52,935 A couple of weeks ago, they had some silly fight, 347 00:14:52,979 --> 00:14:55,590 and she cried for days. 348 00:14:55,633 --> 00:14:57,200 Thank you for letting me know. 349 00:14:57,244 --> 00:14:58,767 I'm gonna do my best to cheer her up. 350 00:14:58,810 --> 00:15:00,856 She's a 16-year-old. 351 00:15:00,900 --> 00:15:02,466 She wants her boyfriend. 352 00:15:02,510 --> 00:15:04,077 Yeah. 353 00:15:04,120 --> 00:15:05,948 And how smart were you when you were 16? 354 00:15:13,695 --> 00:15:15,653 Morgan: Well, what about Selumetinib? 355 00:15:15,697 --> 00:15:18,395 It's shown promising results on related conditions. 356 00:15:18,439 --> 00:15:21,094 And a high occurrence of liver disease. 357 00:15:21,137 --> 00:15:24,488 Binimetinib is similar, but has fewer complications. 358 00:15:24,532 --> 00:15:26,621 Any objections? 359 00:15:29,493 --> 00:15:31,191 Let's start James on that. 360 00:15:35,325 --> 00:15:36,239 [ Door opens ] 361 00:15:39,068 --> 00:15:42,506 This is exciting, working together. 362 00:15:42,550 --> 00:15:44,465 It is. 363 00:15:44,508 --> 00:15:46,902 Although, I'm used to samples and slides 364 00:15:46,946 --> 00:15:47,947 instead of patients. 365 00:15:52,473 --> 00:15:55,215 Patients can be difficult. 366 00:15:55,258 --> 00:15:57,130 But you will be fine. 367 00:16:06,791 --> 00:16:13,755 ♪♪ 368 00:16:16,062 --> 00:16:17,977 Do you need something? 369 00:16:18,020 --> 00:16:20,022 [ Sighs ] 370 00:16:20,066 --> 00:16:22,633 I was curious how James was responding to the Binimetinib. 371 00:16:22,677 --> 00:16:24,461 His urine output is up, 372 00:16:24,505 --> 00:16:26,289 which suggests the lymphatic fluid i-- 373 00:16:27,812 --> 00:16:29,075 And his potassium is a little low. 374 00:16:29,118 --> 00:16:30,728 Can you...give him this? 375 00:16:30,772 --> 00:16:31,729 I wasn't really -- 376 00:16:31,773 --> 00:16:38,693 ♪♪ 377 00:16:40,608 --> 00:16:47,267 ♪♪ 378 00:16:48,790 --> 00:16:49,834 Hi. 379 00:16:49,878 --> 00:16:52,054 I'm Dr. Lever. 380 00:16:52,098 --> 00:16:53,664 The tumor's abutting and possibly infiltrating 381 00:16:53,708 --> 00:16:55,231 the white matter tracts of her fornix. 382 00:16:55,275 --> 00:16:57,190 We'll likely have to remove a section. 383 00:16:57,233 --> 00:16:59,714 That'll affect her ability to form memories. 384 00:16:59,757 --> 00:17:01,194 With a lot of neuropsych rehab, 385 00:17:01,237 --> 00:17:03,718 she may be able to compensate with other pathways. 386 00:17:03,761 --> 00:17:05,546 Studies have shown that positive attitudes 387 00:17:05,589 --> 00:17:07,287 lead to positive outcomes. 388 00:17:07,330 --> 00:17:08,592 You're worried about her attitude? 389 00:17:08,636 --> 00:17:10,203 She's worried about young love. 390 00:17:10,246 --> 00:17:12,292 I'm worried about what Angie is facing aftersurgery -- 391 00:17:12,335 --> 00:17:14,381 physical therapy, cognitive therapy, 392 00:17:14,424 --> 00:17:15,904 one challenge after another. 393 00:17:15,947 --> 00:17:17,210 And what she wants is so simple. 394 00:17:19,951 --> 00:17:21,301 You want to make a sad kid happy? 395 00:17:22,824 --> 00:17:24,260 I guess I do. 396 00:17:24,304 --> 00:17:25,957 Which isn't my job, and I need to stop 397 00:17:26,001 --> 00:17:27,611 getting sucked into people's personal issues. 398 00:17:27,655 --> 00:17:29,874 Is there a way to do that without antagonizing the mother? 399 00:17:33,574 --> 00:17:34,836 Maybe. 400 00:17:34,879 --> 00:17:36,011 [ Elevator bell dings ] 401 00:17:36,055 --> 00:17:37,752 Then make her happy. 402 00:17:41,451 --> 00:17:43,540 [ Both breathing heavily ] 403 00:17:43,584 --> 00:17:47,805 ♪♪ 404 00:17:47,849 --> 00:17:49,111 [ Giggles ] 405 00:17:49,155 --> 00:17:54,943 ♪♪ 406 00:17:54,986 --> 00:17:57,337 We've never gotten this far before. 407 00:17:57,380 --> 00:17:58,468 No. 408 00:17:58,512 --> 00:18:00,035 We haven't. 409 00:18:00,079 --> 00:18:02,690 And you're okay? 410 00:18:02,733 --> 00:18:05,040 I am veryokay. 411 00:18:05,084 --> 00:18:12,003 ♪♪ 412 00:18:13,004 --> 00:18:14,093 [ Gasps ] 413 00:18:14,136 --> 00:18:15,181 Carly. 414 00:18:15,224 --> 00:18:16,660 Ohh. 415 00:18:16,704 --> 00:18:17,966 [ Laughs ] 416 00:18:18,009 --> 00:18:23,885 ♪♪ 417 00:18:23,928 --> 00:18:29,760 ♪♪ 418 00:18:29,804 --> 00:18:31,458 Okay. 419 00:18:31,501 --> 00:18:38,769 ♪♪ 420 00:18:38,813 --> 00:18:42,425 Did...I do something wrong? 421 00:18:42,469 --> 00:18:44,384 No, I'm sorry. It's me. 422 00:18:46,212 --> 00:18:49,345 You said we were okay. 423 00:18:49,389 --> 00:18:50,694 I thought we were. 424 00:18:50,738 --> 00:18:52,522 I-I want us to be. 425 00:18:52,566 --> 00:18:54,089 You have no reason to still be mad. 426 00:18:54,133 --> 00:18:55,612 I'm not mad. 427 00:18:55,656 --> 00:18:56,918 I'm -- I'm just... 428 00:18:56,961 --> 00:18:58,180 [ Cellphone beeping ] 429 00:19:03,142 --> 00:19:04,621 It's Morgan. 430 00:19:04,665 --> 00:19:07,668 The medication caused James an upper GI bleed. 431 00:19:07,711 --> 00:19:10,323 ♪♪ 432 00:19:15,458 --> 00:19:17,156 Have you localized the source of the bleeding? 433 00:19:17,199 --> 00:19:18,548 Working on it. 434 00:19:18,592 --> 00:19:20,898 Seems to be coming from the antrum of the stomach. 435 00:19:20,942 --> 00:19:22,248 Morgan: We stopped the Binimetinib. 436 00:19:22,291 --> 00:19:23,466 On top of causing this, 437 00:19:23,510 --> 00:19:24,728 it hadn't done much to curtail the swelling. 438 00:19:24,772 --> 00:19:26,121 Where's Dr. Lever? 439 00:19:26,165 --> 00:19:28,297 There's the ulcerative lesion. Cautery. 440 00:19:31,387 --> 00:19:33,476 Zebrafish. 441 00:19:33,520 --> 00:19:34,695 They're used in medical research 442 00:19:34,738 --> 00:19:36,349 because of their quick maturation, 443 00:19:36,392 --> 00:19:38,829 and 84% of genes associated with human disease 444 00:19:38,873 --> 00:19:41,136 have a zebrafish equivalent. 445 00:19:41,180 --> 00:19:44,574 You think we should do a transgenic expression 446 00:19:44,618 --> 00:19:48,143 of James' ARAF mutation into the zebrafish genome. 447 00:19:48,187 --> 00:19:49,623 Translation for those of us 448 00:19:49,666 --> 00:19:51,233 without a genetics textbook handy? 449 00:19:51,277 --> 00:19:53,844 We make mini-Jameses, as zebrafish, 450 00:19:53,888 --> 00:19:55,455 all with the same disorder. 451 00:19:55,498 --> 00:19:58,371 Then we test every conceivable drug on those fish. 452 00:19:58,414 --> 00:20:00,199 How long before we can start testing? 453 00:20:00,242 --> 00:20:01,765 If we implant the embryos now, 454 00:20:01,809 --> 00:20:03,463 probably by late afternoon tomorrow. 455 00:20:03,506 --> 00:20:05,160 Get going. 456 00:20:05,204 --> 00:20:07,162 Shaun, go with her. You have Path experience. 457 00:20:07,206 --> 00:20:09,251 ♪♪ 458 00:20:09,295 --> 00:20:10,992 [ Door opens ] 459 00:20:11,035 --> 00:20:13,212 ♪♪ 460 00:20:28,575 --> 00:20:31,926 I understand no means no. 461 00:20:31,969 --> 00:20:35,234 If you don't want to have sex, 462 00:20:35,277 --> 00:20:37,410 I accept that. 463 00:20:37,453 --> 00:20:39,934 But I am very confused. 464 00:20:39,977 --> 00:20:42,241 So am I. 465 00:20:42,284 --> 00:20:44,417 I thought I was fine u-until I -- 466 00:20:44,460 --> 00:20:48,464 I told Lea to move out, like you wanted. 467 00:20:48,508 --> 00:20:51,859 You said that things were okay. 468 00:20:51,902 --> 00:20:52,947 They aren't. 469 00:20:52,990 --> 00:20:54,862 How do I make them okay? 470 00:20:54,905 --> 00:20:58,692 I can't tell you, because I don't know. 471 00:20:58,735 --> 00:21:05,394 ♪♪ 472 00:21:07,657 --> 00:21:13,359 ♪♪ 473 00:21:22,237 --> 00:21:23,760 When I was in chemo, 474 00:21:23,804 --> 00:21:26,372 the nurses used to force that stuff down my throat, 475 00:21:26,415 --> 00:21:28,896 so I know you're not drinking it because of the taste. 476 00:21:28,939 --> 00:21:30,027 [ Chuckles lightly ] 477 00:21:30,071 --> 00:21:32,073 It's fast, easy nutrition. 478 00:21:32,116 --> 00:21:34,510 That and you don't end up puking your guts out in the bathroom. 479 00:21:36,295 --> 00:21:38,732 I was president of this hospital for over 10 years. 480 00:21:38,775 --> 00:21:41,561 I made a few friends, including Jack the janitor -- 481 00:21:41,604 --> 00:21:44,477 talks a lot, A's fan, horrible gossip. 482 00:21:44,520 --> 00:21:47,044 If the methotrexate is making you sick, 483 00:21:47,088 --> 00:21:48,263 we should try another medication. 484 00:21:51,701 --> 00:21:54,225 How can you guarantee that you're not gonna throw up 485 00:21:54,269 --> 00:21:55,966 in the middle of your next surgery? 486 00:21:56,010 --> 00:21:57,316 It won't happen. 487 00:21:59,448 --> 00:22:01,798 Because it only happens if I eat solid food. 488 00:22:01,842 --> 00:22:03,147 And I stopped. 489 00:22:04,627 --> 00:22:06,368 At least at work. 490 00:22:12,679 --> 00:22:18,075 ♪♪ 491 00:22:18,119 --> 00:22:19,816 That is a lot of fish tanks. 492 00:22:19,860 --> 00:22:20,991 40. 493 00:22:21,035 --> 00:22:22,645 So we can test 494 00:22:22,689 --> 00:22:25,387 all of the possible medications for -- 495 00:22:25,431 --> 00:22:27,171 Are you throwing a party? 496 00:22:27,215 --> 00:22:28,434 Hope so. 497 00:22:41,316 --> 00:22:43,536 How are you doing, Shaun? 498 00:22:43,579 --> 00:22:45,276 Since your father passed away? 499 00:22:47,844 --> 00:22:51,544 I don't think about him very much. 500 00:22:56,070 --> 00:22:59,334 My mom...died recently. 501 00:22:59,378 --> 00:23:00,814 I-I don't know if you knew that. 502 00:23:03,164 --> 00:23:05,035 She pops into my head all the time. 503 00:23:07,298 --> 00:23:09,170 Not always the nicest thoughts. 504 00:23:09,213 --> 00:23:16,395 ♪♪ 505 00:23:16,438 --> 00:23:19,528 It's okay not to love them. 506 00:23:21,704 --> 00:23:23,663 They didn't make us who we are. 507 00:23:23,706 --> 00:23:28,885 ♪♪ 508 00:23:32,672 --> 00:23:39,592 ♪♪ 509 00:23:40,767 --> 00:23:47,687 ♪♪ 510 00:23:49,732 --> 00:23:56,696 ♪♪ 511 00:24:00,526 --> 00:24:02,266 Has your mom gone home? 512 00:24:04,617 --> 00:24:07,750 There is one more thing we have to deal with tonight. 513 00:24:07,794 --> 00:24:09,143 [ Scoffs ] 514 00:24:09,186 --> 00:24:10,666 Come on. 515 00:24:10,710 --> 00:24:12,842 How many more sets of imaging can you possibly do? 516 00:24:15,454 --> 00:24:18,021 One of these is your prom dress. 517 00:24:18,065 --> 00:24:21,851 I like the pink, but I think you'd look gorgeous in both. 518 00:24:21,895 --> 00:24:25,551 ♪♪ 519 00:24:25,594 --> 00:24:27,161 Hurry up and choose. 520 00:24:27,204 --> 00:24:28,728 Your date'll be here soon. 521 00:24:30,730 --> 00:24:31,905 [ Laughs ] 522 00:24:31,948 --> 00:24:37,563 ♪♪ 523 00:24:42,263 --> 00:24:44,918 All the medications are in. 524 00:24:44,961 --> 00:24:48,617 Which means more waiting to see which medicine works. 525 00:24:48,661 --> 00:24:50,401 It's hard to be patient. 526 00:24:56,103 --> 00:24:59,541 Do you think the fish control how they react to the meds? 527 00:24:59,585 --> 00:25:02,370 No. 528 00:25:02,413 --> 00:25:04,546 It's just how their bodies respond. 529 00:25:07,854 --> 00:25:09,899 That's how I felt last night. 530 00:25:12,423 --> 00:25:16,471 I thought I was ready for us to be together, but... 531 00:25:16,515 --> 00:25:18,691 my body had a different response. 532 00:25:20,780 --> 00:25:22,695 I can't turn that response off 533 00:25:22,738 --> 00:25:24,653 any more than these fish can control 534 00:25:24,697 --> 00:25:26,873 how their mutation reacts to the medication. 535 00:25:26,916 --> 00:25:33,880 ♪♪ 536 00:25:33,923 --> 00:25:38,928 Was our mutation me going to Wyoming with Lea? 537 00:25:38,972 --> 00:25:45,282 ♪♪ 538 00:25:45,326 --> 00:25:49,591 Do you think we can find our right medication? 539 00:25:49,635 --> 00:25:55,989 ♪♪ 540 00:25:56,032 --> 00:26:02,430 ♪♪ 541 00:26:02,473 --> 00:26:05,825 ♪ I found a love ♪ 542 00:26:05,868 --> 00:26:08,218 ♪ For me ♪ 543 00:26:08,262 --> 00:26:10,264 ♪♪ 544 00:26:10,307 --> 00:26:14,094 ♪ Darling, just dive right in ♪ 545 00:26:14,137 --> 00:26:15,965 ♪ Follow my lead ♪ 546 00:26:16,009 --> 00:26:18,185 ♪♪ 547 00:26:18,228 --> 00:26:21,492 ♪ I found a girl ♪ 548 00:26:21,536 --> 00:26:23,886 ♪ Beautiful and sweet ♪ 549 00:26:23,930 --> 00:26:25,932 You look amazing. 550 00:26:25,975 --> 00:26:30,240 ♪ I never knew you were the someone waiting for me ♪ 551 00:26:30,284 --> 00:26:32,416 So do you. 552 00:26:32,460 --> 00:26:36,856 ♪ 'Cause we were just kids when we fell in love ♪ 553 00:26:36,899 --> 00:26:40,686 ♪ Not knowing what it was ♪ 554 00:26:40,729 --> 00:26:48,476 ♪ I will not give you up this time ♪ 555 00:26:48,519 --> 00:26:51,958 ♪ Darling, just kiss me slow ♪ 556 00:26:52,001 --> 00:26:56,049 ♪ Your heart is all I own ♪ 557 00:26:56,092 --> 00:27:02,708 ♪ And in your eyes, you're holding mine ♪ 558 00:27:02,751 --> 00:27:09,715 ♪ Baby, I'm dancing in the dark ♪ 559 00:27:09,758 --> 00:27:13,849 ♪ With you between my arms ♪ 560 00:27:13,893 --> 00:27:17,810 ♪ Barefoot on the grass ♪ 561 00:27:17,853 --> 00:27:21,074 ♪ Listening to our favorite song ♪ 562 00:27:21,117 --> 00:27:24,730 ♪ When you said you looked a mess ♪ 563 00:27:24,773 --> 00:27:27,471 ♪ I whispered underneath my breath ♪ 564 00:27:27,515 --> 00:27:29,473 Looks like you might be feeling 565 00:27:29,517 --> 00:27:31,867 a little idiotic happiness right now. 566 00:27:31,911 --> 00:27:33,739 Mm... 567 00:27:33,782 --> 00:27:35,088 maybe a touch. 568 00:27:35,131 --> 00:27:40,659 ♪♪ 569 00:27:40,702 --> 00:27:42,356 ♪ No, no ♪ 570 00:27:42,399 --> 00:27:44,271 Dance with a prom king? 571 00:27:44,314 --> 00:27:46,534 Ohh. [ Laughs ] 572 00:27:46,577 --> 00:27:49,755 ♪ You look perfect tonight ♪ 573 00:27:49,798 --> 00:27:51,539 [ Laughs ] 574 00:27:51,582 --> 00:27:57,327 ♪♪ 575 00:27:57,371 --> 00:28:02,942 ♪♪ 576 00:28:02,985 --> 00:28:04,595 [ Monitor beeping rapidly ]He's tachycardic. 577 00:28:06,380 --> 00:28:08,121 We were talking, and then he just stopped. 578 00:28:08,164 --> 00:28:09,818 We need to do a pericardial tap. 579 00:28:09,862 --> 00:28:11,167 Call the cath lab. Tell them we're coming. 580 00:28:11,211 --> 00:28:12,560 No time. We're doing it here. 581 00:28:12,603 --> 00:28:13,909 James, the pain in your chest 582 00:28:13,953 --> 00:28:15,345 is from too much fluid around your heart. 583 00:28:15,389 --> 00:28:17,608 We're gonna put a tube into your chest to drain it. 584 00:28:17,652 --> 00:28:19,045 Call Shaun and Carly. Tell them we're running out of time. 585 00:28:22,178 --> 00:28:28,141 ♪ ...will be loving you till we're 70 ♪ 586 00:28:28,184 --> 00:28:30,970 [ Camera shutter clicking ] 587 00:28:31,013 --> 00:28:33,450 ♪♪ 588 00:28:33,494 --> 00:28:39,805 ♪ And, baby, my heart could still fall as hard at 23 ♪ 589 00:28:41,371 --> 00:28:43,591 ♪♪ 590 00:28:43,634 --> 00:28:46,463 ♪ And I'm thinking about how ♪ 591 00:28:46,507 --> 00:28:51,164 ♪ People fall in love in mysterious ways ♪ 592 00:28:51,207 --> 00:28:52,731 I brought Angie's Bearfeet Bear. 593 00:28:52,774 --> 00:28:53,993 It always makes her feel like sh-- 594 00:28:58,127 --> 00:29:01,000 It's...prom. 595 00:29:01,043 --> 00:29:04,438 Ryan has been wearing his mask all night. 596 00:29:04,481 --> 00:29:09,008 ♪ And I just want to tell you I am ♪ 597 00:29:09,051 --> 00:29:11,706 ♪ So, honey, now ♪ 598 00:29:11,750 --> 00:29:14,883 ♪♪ 599 00:29:14,927 --> 00:29:18,713 ♪ Take me into your loving arms ♪ 600 00:29:18,757 --> 00:29:21,020 Don't let her stay up too late. 601 00:29:21,063 --> 00:29:25,111 ♪ Kiss me under the light of a thousand stars ♪ 602 00:29:25,154 --> 00:29:27,026 ♪♪ 603 00:29:27,069 --> 00:29:29,332 ♪ Place your hand on my beating heart ♪ 604 00:29:29,376 --> 00:29:31,465 ♪♪ 605 00:29:31,508 --> 00:29:33,162 [ Footsteps approach ] 606 00:29:35,991 --> 00:29:38,167 Morgan called. James isn't doing well. 607 00:29:44,478 --> 00:29:47,089 Cross SL-327 off the list. 608 00:29:48,438 --> 00:29:50,919 I see one -- 609 00:29:50,963 --> 00:29:53,574 no, twotumors. 610 00:29:53,617 --> 00:30:00,146 ♪♪ 611 00:30:00,189 --> 00:30:06,805 ♪♪ 612 00:30:17,119 --> 00:30:18,164 Okay. 613 00:30:18,207 --> 00:30:20,470 This is my stop. 614 00:30:20,514 --> 00:30:22,255 I'll see you after. 615 00:30:22,298 --> 00:30:23,822 I love you. 616 00:30:23,865 --> 00:30:25,258 I love you, too, Mom. 617 00:30:28,914 --> 00:30:30,959 Don't worry. Okay? 618 00:30:31,003 --> 00:30:32,700 I got this. 619 00:30:35,137 --> 00:30:36,791 I know you do. 620 00:30:36,835 --> 00:30:38,793 [ Chuckles ] 621 00:30:38,837 --> 00:30:43,058 ♪♪ 622 00:30:43,102 --> 00:30:44,103 [ Chuckles ] 623 00:30:44,146 --> 00:30:45,234 Okay. 624 00:30:45,278 --> 00:30:46,801 Okay. 625 00:30:46,845 --> 00:30:52,198 ♪♪ 626 00:30:52,241 --> 00:30:56,767 What if I wake up and don't remember Ryan at all? 627 00:30:59,901 --> 00:31:02,338 Then... 628 00:31:02,382 --> 00:31:04,079 you'll have the chance to fall in love with him 629 00:31:04,123 --> 00:31:05,907 all over again. 630 00:31:05,951 --> 00:31:09,955 ♪♪ 631 00:31:09,998 --> 00:31:11,043 Okay. 632 00:31:12,261 --> 00:31:13,610 Okay. 633 00:31:13,654 --> 00:31:14,960 [ Breathes shakily ] 634 00:31:15,003 --> 00:31:21,967 ♪♪ 635 00:31:25,013 --> 00:31:27,146 We're down to five potential options. 636 00:31:27,189 --> 00:31:29,583 I don't need five potential. I need one actual. 637 00:31:29,626 --> 00:31:31,019 There are two that best curb -- 638 00:31:31,063 --> 00:31:32,151 Choose one. 639 00:31:33,500 --> 00:31:37,112 We should try Refametinib. 640 00:31:37,156 --> 00:31:38,897 It caused abnormal cell growth. 641 00:31:38,940 --> 00:31:40,724 Trametinib is safer. 642 00:31:40,768 --> 00:31:42,509 Which doesn't mean it's safe. 643 00:31:42,552 --> 00:31:43,727 Nothing's safe. 644 00:31:43,771 --> 00:31:44,990 Which do you want us to do? 645 00:31:47,166 --> 00:31:48,123 [ Sighs ] 646 00:31:49,995 --> 00:31:51,170 Trametinib. 647 00:31:51,213 --> 00:31:52,345 That's the one. 648 00:31:52,388 --> 00:31:57,916 ♪♪ 649 00:31:57,959 --> 00:32:00,048 Saline in. 650 00:32:00,092 --> 00:32:02,442 Advancing scope toward the third ventricle. 651 00:32:02,485 --> 00:32:04,444 Claire, hold gentle pressure on the tumor 652 00:32:04,487 --> 00:32:06,576 while I cut off its blood supply. 653 00:32:06,620 --> 00:32:08,752 [ Monitors beeping steadily ] 654 00:32:13,148 --> 00:32:14,802 We've got some significant bleeding. 655 00:32:14,845 --> 00:32:16,325 Adjust the scope and suction. 656 00:32:21,026 --> 00:32:23,593 Look higher. 657 00:32:23,637 --> 00:32:25,160 Septal vein -- there's your bleeder. 658 00:32:25,204 --> 00:32:26,118 Cauterize away. 659 00:32:38,304 --> 00:32:44,963 ♪♪ 660 00:32:46,573 --> 00:32:53,493 ♪♪ 661 00:32:54,842 --> 00:33:01,805 ♪♪ 662 00:33:03,372 --> 00:33:10,031 ♪♪ 663 00:33:11,815 --> 00:33:13,078 Micro dissector. 664 00:33:18,387 --> 00:33:20,259 The tumor's immobile. 665 00:33:20,302 --> 00:33:22,174 I can't resect it without injuring the nerve tracts. 666 00:33:22,217 --> 00:33:24,089 She'd be comatose. 667 00:33:24,132 --> 00:33:25,264 Try sharp dissection. 668 00:33:26,874 --> 00:33:28,745 I can't get a plane. How bad? 669 00:33:28,789 --> 00:33:30,878 It's completely invaded her thalamus. 670 00:33:30,921 --> 00:33:34,099 Thin it out with a suction aspirator. 671 00:33:39,887 --> 00:33:41,932 It's too adherent. 672 00:33:41,976 --> 00:33:43,673 If I keep going, I'm gonna kill her. 673 00:33:45,545 --> 00:33:47,242 Any ideas? 674 00:33:50,071 --> 00:33:56,121 ♪♪ 675 00:33:59,515 --> 00:34:05,217 ♪♪ 676 00:34:09,395 --> 00:34:12,485 Tell ICU Angie will be coming sooner than we planned. 677 00:34:14,400 --> 00:34:15,836 Let's close her up. 678 00:34:15,879 --> 00:34:21,929 ♪♪ 679 00:34:23,931 --> 00:34:29,980 ♪♪ 680 00:34:34,681 --> 00:34:36,378 What's next? 681 00:34:36,422 --> 00:34:38,467 Another round of radiation, chemo? 682 00:34:40,904 --> 00:34:44,169 Her carcinoma is... 683 00:34:44,212 --> 00:34:46,258 unlikely to respond to those therapies. 684 00:34:49,957 --> 00:34:51,350 No. 685 00:34:51,393 --> 00:34:53,482 We have to try. 686 00:34:53,526 --> 00:34:55,005 Angie will want to fight. 687 00:34:55,049 --> 00:34:56,355 [ Monitor beeping rapidly ]She's seizing. 688 00:34:56,398 --> 00:34:57,530 Give me lorazepam and Dilantin, stat. 689 00:34:57,573 --> 00:34:58,574 Phenobarb and propofol on deck. 690 00:34:58,618 --> 00:35:04,711 ♪♪ 691 00:35:21,728 --> 00:35:22,555 You're crying. 692 00:35:26,341 --> 00:35:27,168 Yes. 693 00:35:31,216 --> 00:35:32,434 Why? 694 00:35:35,045 --> 00:35:37,439 I found James on Facebook. 695 00:35:37,483 --> 00:35:39,485 [ Sniffles ] 696 00:35:39,528 --> 00:35:41,791 He and Marjorie want to go to Costa Rica. 697 00:35:43,924 --> 00:35:47,232 Their dog is a three-legged rescue named Tripod. 698 00:35:47,275 --> 00:35:51,845 ♪♪ 699 00:35:51,888 --> 00:35:55,327 He's not a slide. He's a person. 700 00:35:55,370 --> 00:35:56,893 He's a good person. 701 00:35:56,937 --> 00:35:58,504 And he might die. 702 00:35:58,547 --> 00:36:00,332 [ Sniffles ] 703 00:36:00,375 --> 00:36:02,247 This is why I like to stay in the lab. 704 00:36:02,290 --> 00:36:07,861 ♪♪ 705 00:36:07,904 --> 00:36:10,124 That... 706 00:36:10,168 --> 00:36:12,605 is a very dumb thing to say. 707 00:36:15,782 --> 00:36:18,132 If you had stayed in the lab, 708 00:36:18,176 --> 00:36:21,091 James would probably be dead already. 709 00:36:24,486 --> 00:36:30,057 Your plan with the zebrafish gave him a chance. 710 00:36:30,100 --> 00:36:35,323 It was a beautiful, perfect idea, 711 00:36:35,367 --> 00:36:37,978 from a beautiful, almost perfect person. 712 00:36:38,021 --> 00:36:44,071 ♪♪ 713 00:36:44,114 --> 00:36:46,552 Your earlobes are lopsided. 714 00:36:46,595 --> 00:36:48,597 [ Chuckles ] 715 00:36:48,641 --> 00:36:54,386 ♪♪ 716 00:36:55,735 --> 00:37:01,828 ♪♪ 717 00:37:03,133 --> 00:37:09,705 ♪♪ 718 00:37:20,281 --> 00:37:22,631 I'm so sorry. 719 00:37:22,675 --> 00:37:24,633 We couldn't save her. 720 00:37:24,677 --> 00:37:26,722 [ Breathing raggedly ] 721 00:37:26,766 --> 00:37:32,511 ♪♪ 722 00:37:36,166 --> 00:37:38,125 [ Crying ] 723 00:37:38,168 --> 00:37:45,088 ♪♪ 724 00:37:45,132 --> 00:37:46,742 Ms. Valens? 725 00:37:46,786 --> 00:37:52,531 ♪♪ 726 00:37:56,230 --> 00:38:02,323 ♪♪ 727 00:38:05,631 --> 00:38:11,419 ♪♪ 728 00:38:19,209 --> 00:38:20,298 Nice call on the zebrafish. 729 00:38:23,562 --> 00:38:29,307 ♪♪ 730 00:38:32,048 --> 00:38:38,141 ♪♪ 731 00:38:40,883 --> 00:38:43,233 About our paper, let's meet weekly. 732 00:38:43,277 --> 00:38:45,584 I'm thinking lunch every Tuesday in the cafeteria. 733 00:38:45,627 --> 00:38:46,498 Perfect. 734 00:38:54,636 --> 00:38:57,030 [ Knock on door ] 735 00:38:57,073 --> 00:38:59,337 I heard about Melendez's patient. 736 00:39:02,731 --> 00:39:03,732 Yeah. 737 00:39:14,308 --> 00:39:16,049 You were right. 738 00:39:16,092 --> 00:39:19,748 I should probably try another medication for my RA. 739 00:39:22,055 --> 00:39:23,491 I need solid food. 740 00:39:35,242 --> 00:39:36,852 Melendez: Claire? Wait up. 741 00:39:38,201 --> 00:39:39,899 You okay? 742 00:39:39,942 --> 00:39:41,770 Fine. I'm just tired. 743 00:39:44,120 --> 00:39:46,340 You did an amazing thing for Angie. 744 00:39:46,384 --> 00:39:48,908 You gave her mother a memory that she will have forever. 745 00:39:48,951 --> 00:39:51,301 Well, it won't make up for the daughter she lost. 746 00:39:51,345 --> 00:39:52,999 You're angry. 747 00:39:53,042 --> 00:39:55,436 I'm not. I am sad. 748 00:39:55,480 --> 00:39:57,699 Who are you angry at?I'm not. 749 00:39:57,743 --> 00:39:59,832 Are you angry at me and Glassman because we couldn't save her? 750 00:39:59,875 --> 00:40:01,573 No! At Angie? 751 00:40:01,616 --> 00:40:04,706 No, you can't be mad at someone for dying! 752 00:40:04,750 --> 00:40:06,969 That's not true. You know that. 753 00:40:07,013 --> 00:40:09,581 ♪♪ 754 00:40:09,624 --> 00:40:11,147 She was sick. 755 00:40:11,191 --> 00:40:13,411 And she was trying to get better. 756 00:40:13,454 --> 00:40:16,022 She failed and left you alone. 757 00:40:16,065 --> 00:40:19,808 After you'd spent a lifetime trying to take care of her. 758 00:40:19,852 --> 00:40:21,027 You have every reason to be mad at your mother. 759 00:40:23,159 --> 00:40:25,118 I hate feeling this way. 760 00:40:25,161 --> 00:40:26,946 My whole life, I've been angry at her, 761 00:40:26,989 --> 00:40:29,688 and now it will never change. 762 00:40:29,731 --> 00:40:31,472 I don't know how to stop. 763 00:40:35,041 --> 00:40:37,652 Therapy will help. 764 00:40:37,696 --> 00:40:39,349 Time will help. 765 00:40:41,482 --> 00:40:43,832 There is one other thing that's worked for me. 766 00:40:43,876 --> 00:40:49,925 ♪♪ 767 00:40:51,187 --> 00:40:52,275 [ Keys clack ] 768 00:40:52,319 --> 00:40:53,842 [ Giggles ] 769 00:40:53,886 --> 00:40:56,192 ♪♪ 770 00:40:56,236 --> 00:40:58,673 Did we fix our mutation? 771 00:40:58,717 --> 00:41:02,285 ♪♪ 772 00:41:02,329 --> 00:41:03,373 [ Laughs ] 773 00:41:03,417 --> 00:41:09,510 ♪♪ 774 00:41:11,730 --> 00:41:13,471 That the best you got? 775 00:41:13,514 --> 00:41:19,564 ♪♪ 776 00:41:22,828 --> 00:41:28,877 ♪♪ 777 00:41:32,359 --> 00:41:38,408 ♪♪ 778 00:41:45,546 --> 00:41:51,596 ♪♪ 779 00:41:54,381 --> 00:42:00,430 ♪♪ 780 00:42:03,608 --> 00:42:09,657 ♪♪ 781 00:42:15,707 --> 00:42:17,970 [ Man laughs ] 782 00:42:18,013 --> 00:42:21,147 ♪♪ 48987

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