Original subtitles

All known organisms are made up of cells.

Humans, of course, have lots of them.

Our skin, organs, bones... They are made of them.

Each cell has a nucleus at its center.

Inside they carry a map of how each part of our body is.

This is DNA, genes.

And there are many more things within each cell.

Every part of it, like the nucleus...

It has its own DNA.

His name is: Mitocondria.

The main function of these Mitochondria...

It is the creation of energy.

But why are the Mitochondria here?

They have their own genes...

so they are also organisms.

Parasites-

A way of life that invades our cells.

(Parasitism)

Mariko! Mariko!

Now...

We will see something very strange.

Parents inherit properties such as character or appearance.

But the Mitochondria are only transmitted by the mother.

The Mitochondria that each one carries in your body...

They come from your mothers.

So in the DNA of each Mitocondria...

the mothers of all of us are reflected.

We have discovered who was the Eve (Eva) of mythology.

Let's go back 200,000 years to a distant past.

We are in Africa.

It was here that Eve (Eva) appeared.

The first human, the first woman to carry Mitochondria.

We call it: «Mitochondria Eve».

Why did you stop coming here?

I already explained it to you...

you have to come three times each week...

to take out everything your body does not need.

Yes... but I'm fed up.

In this school...

we study the inside of our bodies...

to know how medicines act.

You can wash your hands and send the germs to gargle.

But the real fight against germs is inside you.

There are many types of tiny things living inside of us.

You are deceiving us...

That is asquerosoooo.

Yes, but I've already told you about the immune system...

Get that out of your head.

I do not believe that!

You can digest food only because there are bacteria in your intestines.

!Gross!

Hey! A snail!

Do you want me to tell you a story?

What history?

About the bugs inside the snail.

Again?

They make the shell of the snail hard.

So, in principle, they are good for the snail.

With a harder shell they can live longer.

But when the snail becomes big...

the bugs climb up to their horns.

Why?

Usually...

the snails prefer dark places, but now they come out with the sun.

The bugs make the horns swell...

and control them so that they can shake.

Why do they do that?

Only the birds of the sky know it.

The horns look like an insect...

that the birds love to eat.

So is...

What the bugs really want...

is to be able to go far inside the stomach of the birds.

They make the birds eat the snail.

!! That's horrible!!

Finished the science class for today!

It's time to leave.

Has everything been clear?

We have lots of germs living inside of us, right?

And they will also control us...

when we become older?

Do not worry.

We are superior beings, with a more complex way of life.

!Come on!

We have parasites, like microbes...

for a billion years.

But at this moment they have become something vital for us.

We move, we think..., all thanks to the Mitochondria.

The two parties have decided to live together in symbiosis.

Symbiosis -

!Teacher!

Yes?

To us... it serves us for something...

the study of this Mitochondria?

We already know what anomalies in the DNA of the Mitochondria...

They occur in cases such as Diabetes or Cirrhosis.

So, we can say that diseases are like energy losses.

Healthy mitochondria could grow and enter the dead cells.

Once the cellular activity is restored, this anomaly could be corrected.

This is what my study is based on.

Let's see some Mitochondria!

Thank you.

I still can not go home, I still have work to do.

And you can not postpone it?

I have to deliver this data.

We still work only with animals.

But very soon we could be ready to help the sick.

Oh! Go!

You forgot...

Our...

First...

Anniversary.

I bought you a gift...

I feel stupid.

Do not worry, half expected it.

I am sorry.

See you soon...

!Do not look at me like that!

Work hard.

I will leave as soon as possible!

I've been waiting for you for so long...

What happen?

Nothing.

How was the conference, Doctor?

Very well, I think...

I have tried with this concentrate.

And what use have you given?

It is a tinted gel.

Agree.

! Dr. Nagashima! The rat livers are improving!

The healthy cells that we introduced last week...

they have reversed atrophy.

These are from the last week.

!At last!

Cultivate these cells and monitor the mitochondria.

Nagashima!

Do not make St Asakura work too hard.

You have to submit a project next month.

All right, sir.

There is no problem

I learn a lot by helping Prof. Nagashima.

I can understand that you are so excited.

There must be so much to discover...

- Excuse us. - With your permission...

The Mitochondria have every time...

a different way of life, right? Like bacteria.

Yeah, so what?

The children were asking me...

if one day they could take control of a human body.

There is a theory that says...

Mitochondria do not have enough DNA to live by themselves.

But some can be transferred outside the nucleus.

Which means that some of the core genes...

they are associated with the Mitocondria.

Very good, but...

Does the Mitocondria have its own membership agenda?

«CULTIVATION OF LIVER CELLS».

! Dr. Nagashima!

Are you a relative of Kiyomi Nagashima?

How is it going...?

Very badly injured.

Will it live out of this?

Sufers respiratory arrest due to a stroke.

They are operating it now.

Please... Notify the rest of the family.

You are her husband, right?

Yes.

There was a great cerebral hemorrhage.

We operated it as soon as it arrived.

We have put in assisted breathing.

It can not breathe on its own.

We have tested with high doses of stimulants.

There is loss of brain activity...

and damage to your spine.

What are the chances of it coming out of the coma?

Sorry to tell you this...

but he is on the verge of brain death.

It's me...

Can you hear me?

Kiyomi.

You have to wake up!

Today is a great day...

Our first...

Toshiaki!

Kiyomi...

It's still early for you to leave us, like your mother...

This is the brain activity tonight.

This is six hours later.

All the tests are negative.

Your brain has stopped working.

It's definitive... it's clinically dead.

Mr. Nagashima.

This is Sta. Odagiri, coordinator of transplants.

How are you?

His wife registered her kidneys as organs for transplant.

Transplant?

It was registered in the donor bank.

I knew it?

It was registered about six months ago... almost without thinking.

Your kidney can save some patient with chronic kidney failure.

Unfortunately...

There is no kind of cure for that state.

The patient must undergo dialysis on a regular basis.

I assure you that your wife's kidney will have a good profit.

I think we should respect his will...

if that's what she wanted...

Are you your father?

Could you sign the family consent in this document?

Could we, at least...

study if there is any incompatibility?

We have a possible kidney donor in the city.

A 25-year-old woman, brain dead from hemorrhage.

I compared the results of your HLA...

looking for a compatible receiver.

Your patient tops the list.

I get it.

There is no other possible receiver.

Can I make the request?

Sure, please...

I need some time.

The family has not yet agreed.

In what hospital is it?

Nurse...

Does this mean that Kiyomi is dead?

I come to beg you to allow the transplant.

His wife's compatibility tests have found a receiver.

Mr. Nagashima.

Mr. Nagashima, I understand how you feel...

but this was his last will.

The kidney is not going to be wasted.

Please, free that patient from his suffering.

She is a 12 year old girl.

Yoshizumi, from the Central Hospital.

Doctor, I'll take care of this.

Please, let us use that kidney.

Please Doctor... That goes against the rules!

It's just a girl!

I want to cure her and let her go! Mr. Nagashima!

!Mr. Nagashima!

!Doctor!

Just listen to me! Please!

!Mr. Nagashima!

Give it to me! I beg you!

I've already disappointed that girl on another occasion.

Two years ago, I did another kidney transplant.

I thought everything had gone well...

but in the end his body rejected him.

The girl trusted me...

and I dropped it.

!Please!

Give me another chance!

Kiyomi is alive.

Kiyomi... she is not dead.

!!! It is still alive!

Ok, I accept.

Really?

But with one condition...

I will give you your kidney if in exchange you give me your liver.

For what?

I'm not a doctor...

so I can not operate it myself.

You will extract your kidney to give it to me.

But...

What do you intend to do with it?

Mariko...

Mariko...

Can you trust me one more time?

Your heart has stopped.

11:31 a. m.

We confirm his death.

I could not do anything to save her.

We will start the operation now.

I beg you...

Please, Doctor...

What's going on here?

Hurry up.

0:04 p. m.

33 minutes after death.

Let's start the extraction.

!Merry Christmas!

!Take!...the next.

Give me two, please.

Here you go...

!Two!

Today is my birthday... so give me two.

Go... seriously?

Kataoka... Kiyomi?

It is the same symbol as to write «Christmas Eve».

Happy Birthday.

Only one?

!Give me a break!

What happen?

The students in the lab are nagging me.

They say...

I should do something to not let you escape.

It is true...

I could escape.

"I wear..."

so long waiting for you »..

So I have to do it:

Since the first time...

that I saw you...

Let's get them out.

Something happens?

Nothing...

It's hot...

Your daughter will be fine.

We will prepare everything.

The doctor will arrive right away.

Doctor... what does this mean?

!Doctor!

What are you doing?

Extracting your liver.

We are not here for that!

!No time to lose!

!Quiet!

Wait here.

Here is your liver.

!Mr. Nagashima!

And what about the body of his wife?

Is everything alright?

Would you mind leaving me?

!! That you leave!

Should not be with his wife?

Kiyomi... is here.

Time since the donor's death: 123 minutes.

69 minutes from extraction.

We are going to transplant it.

Time: 1:34 p. m.

The kidney...

Mariko...

We take her to a sterile room. Do not worry.

Everything went well.

!Doctor!

This time... everything has gone great.

!Many thanks!

Kiyomi... you're so beautiful...

We had not seen her so happy for many years.

He does not know how much I appreciate it...

to the people who donated it.

!Doctor! Something happens to Mariko!

Mariko... what's the matter with you?

It was just a bad dream.

It has not been a dream!

It was just a nightmare!

It was not a dream!

Everything will be fine... the Doctor is already here.

Calm down, Mariko...

!I have it here!

I'm sorry in here!

!Here!! Inside my stomach!

Get me out, doctor!

!Quick!.! Take it out!

Mariko...

!The operation was a success!

There is nothing to worry about.

Be brave, Mariko...

You're fine... You're fine, Mariko...

That's right, Kiyomi...

Come on...

These are cells of the new kidney...

expanded 16,000 times.

What do you think about this?

I've never seen a Mitochondria like this.

They are three times bigger... of its normal size.

Also... there is a greater amount.

And they are reproducing much faster every day.

We take this after the operation...

and it seemed all very strange.

You gave the donor's liver to her husband, right?

And what about that?

What is this, Kiyomi?

Kiyomi?

Can we talk about my project?

Now I am very busy.

Is there something about his wife...

What should I know?

The cells of the kidney are growing like crazy!

Mr. Nagashima.

What happened to the liver?

What did you do with him?

Kiyomi is alive.

Do you think...

What was going to stop me while she was dying?

You will not be growing those cells, right?

No one else would have had to watch her die.

But... I've found a way to keep Kiyomi alive.

But what's wrong with you?

Why do you cultivate your wife's cells?

Each and every one of your cells... It's Kiyomi.

!Are you crazy!

You kept Kiyomi alive until you transplanted the kidney...

to your patient.

And I make him live again by growing his cells.

What is the difference?

«The stimulation of peroxybial enzymes springs...

from unsaturated fatty acids of the Mitochondria...

of the liver of rats ».

«The stimulation of peroxybial enzymes springs...

«The stimulation of peroxybial enzymes springs... from unsaturated fatty acids...

«Of the Mitochondria» ..

«ln the Mitochondria of» ..

Kiyomi?

Look at my body.

You remember...

true?

You had him near you so many times...

You only loved me.

It's me... Kiyomi.

Toshiaki.

I still hear "Toshiaki"...

from the back of my head.

Again that strange voice that I heard when I saw him for the first time...

like calling inside my ears.

Again something hot sprouts...

from the deepest part of my interior.

I feel like my veins are going to burst...

and I can not breathe.

When he talks to me about his work...

It makes your voice sound friendly.

Only the word "Mitochondria" it makes my heart throb...

very violently, full of joy...

I'm losing my mind.

Coming Soon...

I will be controlled by that voice...

for that proud voice...

The only one you loved... It was me.

Kiyomi loved you...

because I made it.

I had her talk to you that Christmas...

with a voice that would make you fall in love.

Your breathing accelerated.

I had chosen you...

why would you be...

who was going to cultivate us.

Who you are?

I had been waiting for you...

I'm scared... I'm scared... I'm scared... I'm scared...

Doctor?

I will present my project in a moment.

There is something I have to say...

to all humanity.

I was looking for you.

The state of the girl is more strange every day.

Your uterus is changing.

And it's also changing its cellular structure.

Thank you very much -

Sachiko Asakura, from the National University of Biochemistry...

Tell us about the «Retinoid Receptors...

in the DNA Derivatives of the Mitochondria ».

(Does he not think to listen to me?)

You are very lucky to be the ones who are going to hear us today.

You will be the first to hear about the new world that will begin.

And we are also happy to be able to address human beings.

Finally...

the Mitochondria are going to be free.

What's wrong with that girl?

The Mitochondria is talking to us.

We have watched you since you were microorganisms.

We gave you the energy with which you have evolved.

We even remember your ancestor... Eve. The Mitochondria had already taken over.

We have waited a long time...

until now.

A billion years.

Answer... you're Eve, right?

But that it does?

It's over.

This is not your project...

! Shut up and sit down!

We have power over the Mitochondria of your cells...

and we can control the energy that they transmit.

Mitochondrial energy converted into heat...

impulses...! thousands of volts!

Can not be...! It's stupid!

We had to wait for you to evolve to this point.

You have done better than we thought...

but your mission here is over.

Now...

We are going to take your place.

A new evolution will begin.

We have found a perfect matrix for our purposes.

Our descendants will be... the definitive way of life.

Unfortunately...

you will not be here to see it blossom.

We... we will destroy all of you.

Asakura!

He is okay...

What have we done...

between the Mitocondria and me?

They are going to father a son.

Mitochondria can not procreate a child...

only from sperm.

The uterus of my patient...

It is transforming.

!!! Out of here!!!

- Any problem? - Do not.

Mariko, what is the matter?

!! Get away!!

- Mariko... what's happening? - !! Get away!!

Makiko.

Mariko, what's the matter with you?

I'm burning.

- Where? - ! I'm burning!

I'm burning...

What has happened?

Kiyomi's mitochondria can not reproduce on their own.

They need a matrix.

They controlled Kiyomi to donate his kidney.

They had everything planned!

Even that I would grow your cells.

And what about my patient?

Mariko!

!Here!

Mariko!

It's here...

Hey? What?

What's here?

Who you are?

Kiyomi...! for!

Give me my daughter...!

!! Quiet!

Do not let it leave the building!

!Doctor!

Doctor... help me...

I'm here... Doctor...

Makiko?

Doctor...

Doctor, I'm here...

Doctor...

Doctor, help me...

Doctor... I'm here.

Are you okay?

The rooftop...

!Doctor!

!Wait!

Let the girl leave!

Give it back!

Kiyomi, give me back the girl!

Do not meddle.

This is evolution.

The child that she is going to give birth will be the pure "Mitochondria Eve".

Kiyomi?

Are you there?

Lately she could feel us.

We... we were waiting for her.

We made him faint, we caused the accident.

And as we expected... you cultivated your cells.

And now we have the perfect matrix.

Say goodbye... to humanity.

I can not forget you.

Neither do we.

It was hard to train the Kiyomi...

I would have to fall in love.

The first time I saw her...

«Christmas Eve».

We change the destination... the night you met.

We created the Kiyomi that you loved.

But I saw her before that.

Your first day of college...

on the Campus.

She was wearing a pink dress...

and a bright and innocent smile...

I stared at her...

thinking how wonderful it would be...

to be with her.

We made Kiyomi's heart beat hard for you.

We create your love for you.

Kiyomi...

!Get away!

- Come here. - ! Still!

Returns...

Come back with me...

Come back with me.

!For!

!Get away!

Let me hug you.

What happened?

You had a bad dream