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These are the user uploaded subtitles that are being translated: 1 00:00:05,360 --> 00:00:07,120 The universe. 2 00:00:07,200 --> 00:00:11,960 Vast, dynamic and explosive. 3 00:00:12,040 --> 00:00:14,040 But this huge cosmos 4 00:00:14,120 --> 00:00:17,040 with its billions of galaxies and countless stars 5 00:00:17,120 --> 00:00:19,080 isn't the only one. 6 00:00:19,160 --> 00:00:22,480 We share our lives with another universe. 7 00:00:22,560 --> 00:00:24,160 The world of the small, 8 00:00:24,240 --> 00:00:27,440 of the viruses, of the bacteria. 9 00:00:27,520 --> 00:00:31,960 We call this strange hidden kingdom the microcosmos. 10 00:00:32,040 --> 00:00:34,800 The microcosmos is incredibly important. 11 00:00:34,880 --> 00:00:37,800 Even though we can't see it, it's everywhere. 12 00:00:37,880 --> 00:00:41,600 It's almost like another universe or another world, all in its own. 13 00:00:42,640 --> 00:00:44,400 It guided our evolution. 14 00:00:44,480 --> 00:00:46,880 We wouldn't be here without the microcosmos. 15 00:00:46,960 --> 00:00:49,240 And it keeps us alive. 16 00:00:49,320 --> 00:00:53,840 The microcosmos is responsible for the very oxygen that we breathe. 17 00:00:54,880 --> 00:00:59,240 And it will influence our future as we venture out into space. 18 00:00:59,320 --> 00:01:03,400 If we were ever to find a place where there is life, 19 00:01:03,480 --> 00:01:05,960 potentially a new microcosmos, 20 00:01:06,040 --> 00:01:09,200 we would have no immunity if they're bad. 21 00:01:09,280 --> 00:01:12,120 We share our world with the microcosmos. 22 00:01:12,200 --> 00:01:15,440 Will we coexist in an uneasy peace... 23 00:01:16,520 --> 00:01:18,280 ..or will it destroy us? 24 00:01:32,360 --> 00:01:36,400 A strange, invisible assassin stalks its prey. 25 00:01:36,480 --> 00:01:38,920 It attacks and hijacks the cell, 26 00:01:39,000 --> 00:01:42,240 forcing it to produce hundreds of new raiders. 27 00:01:43,640 --> 00:01:47,680 This is what happens when the microcosmos turns on us. 28 00:01:47,760 --> 00:01:52,640 In 2020, we experienced this invasion of the body snatchers 29 00:01:52,720 --> 00:01:53,720 first hand. 30 00:01:54,760 --> 00:01:57,880 A tiny virus caused a global pandemic. 31 00:01:57,960 --> 00:01:59,920 Covid-19. 32 00:02:00,000 --> 00:02:03,200 This pandemic makes me see the world completely differently, 33 00:02:03,280 --> 00:02:05,320 because there was an invisible universe, 34 00:02:05,400 --> 00:02:07,600 one that covers me and is within me, 35 00:02:07,680 --> 00:02:10,360 that I pretty much ignored for the most part. 36 00:02:11,760 --> 00:02:13,720 Maybe we ignore this other universe 37 00:02:13,800 --> 00:02:15,960 because it's invisible to the naked eye. 38 00:02:17,000 --> 00:02:19,760 We live in a largely invisible universe. 39 00:02:19,840 --> 00:02:22,240 We can't see everything that's going on. 40 00:02:22,320 --> 00:02:24,520 Some of the bigger stuff, we can't see very well, 41 00:02:24,600 --> 00:02:27,440 and, in fact, a lot of the littlest stuff we can't either. 42 00:02:27,520 --> 00:02:30,360 Just because something is too small to see 43 00:02:30,440 --> 00:02:32,200 doesn't mean it's not important. 44 00:02:32,280 --> 00:02:36,800 In fact, very, very tiny things have a huge impact on our lives. 45 00:02:37,840 --> 00:02:40,440 Some of these impacts are beneficial, 46 00:02:40,520 --> 00:02:44,080 but they're overshadowed by the devastating effects of disease. 47 00:02:45,120 --> 00:02:49,960 The longest-running conflict that humanity has been engaged in 48 00:02:50,040 --> 00:02:52,560 is that against the microcosmos. 49 00:02:52,640 --> 00:02:57,320 Our long-running battle against the bacteria and viruses 50 00:02:57,400 --> 00:02:58,720 that are trying to kill us. 51 00:02:58,800 --> 00:03:02,760 A century ago, we faced the Spanish flu. 52 00:03:02,840 --> 00:03:06,520 This absolutely annihilated Europe at the time. 53 00:03:06,600 --> 00:03:08,760 It caused million upon millions of deaths. 54 00:03:08,840 --> 00:03:10,880 So this is definitely not the first pandemic. 55 00:03:10,960 --> 00:03:13,000 It quite frankly probably isn't the last one. 56 00:03:13,080 --> 00:03:15,920 In a way, the coronavirus has forced us 57 00:03:16,000 --> 00:03:19,240 to come to a greater understanding of the microscopic world. 58 00:03:21,000 --> 00:03:23,520 The microcosmos is complex. 59 00:03:23,600 --> 00:03:27,800 While some parts kill us, others keep us alive. 60 00:03:27,880 --> 00:03:31,000 The microcosmos is important for us to survive, 61 00:03:31,080 --> 00:03:34,040 in order for us to do all of the things that our body does, 62 00:03:34,120 --> 00:03:36,640 in order for us to live and grow and thrive. 63 00:03:36,720 --> 00:03:39,480 Our lives depend on the microcosmos. 64 00:03:39,560 --> 00:03:41,440 The air we breathe 65 00:03:41,520 --> 00:03:43,560 and the surface of the Earth around us 66 00:03:43,640 --> 00:03:47,160 has been profoundly affected by the microcosmos. 67 00:03:47,240 --> 00:03:52,120 The invisible microcosmos operates in every part of the world. 68 00:03:52,200 --> 00:03:54,960 This world that you can't see is everywhere. 69 00:03:55,040 --> 00:03:58,320 From geothermal hot springs to glaciers, 70 00:03:58,400 --> 00:04:01,640 to deep sea hydrothermal vent systems. 71 00:04:02,800 --> 00:04:06,440 We have discovered that every cubic foot of Earth's atmosphere 72 00:04:06,520 --> 00:04:09,600 and its oceans contain millions of viruses. 73 00:04:10,640 --> 00:04:13,480 There are more viruses here on Earth 74 00:04:13,560 --> 00:04:16,320 than there are stars in the universe. 75 00:04:16,400 --> 00:04:18,040 That's incredible. 76 00:04:18,120 --> 00:04:22,960 Even though they're around one 400th the thickness of human hair, 77 00:04:23,040 --> 00:04:26,360 stuck end to end, all the viruses on Earth 78 00:04:26,440 --> 00:04:28,960 would stretch 100 million light years. 79 00:04:30,040 --> 00:04:33,400 That's 40 times the distance to our neighbouring galaxy, 80 00:04:33,480 --> 00:04:35,160 Andromeda. 81 00:04:35,240 --> 00:04:38,360 That really makes us ask, whose planet is this anyway? 82 00:04:38,440 --> 00:04:40,360 If you just added this up by sheer numbers, 83 00:04:40,440 --> 00:04:42,520 you would say this is the virus planet. 84 00:04:42,600 --> 00:04:46,880 The microcosmos has also taken over our bodies. 85 00:04:46,960 --> 00:04:49,240 We're only partly human. 86 00:04:49,320 --> 00:04:52,440 The fact that so little of my own body, of everyone's body, 87 00:04:52,520 --> 00:04:54,480 is human cells kinda leaves you wondering 88 00:04:54,560 --> 00:04:56,160 what's the rest of it made of, right? 89 00:04:56,240 --> 00:04:58,440 It is astonishing that we share our bodies 90 00:04:58,520 --> 00:05:02,120 with over 380 trillion viruses. 91 00:05:03,160 --> 00:05:06,120 And over 39 trillion bacterial cells. 92 00:05:07,200 --> 00:05:09,840 The average human has more bacterial cells 93 00:05:09,920 --> 00:05:11,520 inside their body 94 00:05:11,600 --> 00:05:14,280 than their are human cells inside their body. 95 00:05:14,360 --> 00:05:16,280 So, what are we really? 96 00:05:16,360 --> 00:05:18,280 There are moments in the history of science 97 00:05:18,360 --> 00:05:20,880 that I actually remember where I was when they happened, 98 00:05:20,960 --> 00:05:23,520 when, for example, we detected two colliding black holes 99 00:05:23,600 --> 00:05:24,680 or something like that. 100 00:05:24,760 --> 00:05:26,520 But another one was when I realised 101 00:05:26,600 --> 00:05:30,120 that almost half our body is actually not human. 102 00:05:30,200 --> 00:05:32,360 I mean, that is crazy. 103 00:05:32,440 --> 00:05:34,200 For people that are scared of bacteria, 104 00:05:34,280 --> 00:05:36,560 that's a really interesting thing to know, right? 105 00:05:38,080 --> 00:05:42,000 Bacteria help us digest food, produce vitamins, 106 00:05:42,080 --> 00:05:43,720 and even influence our mood. 107 00:05:44,760 --> 00:05:46,000 But what are they? 108 00:05:47,480 --> 00:05:50,360 Bacteria are single-celled organisms 109 00:05:50,440 --> 00:05:52,560 with a cell wall and a central nucleus 110 00:05:52,640 --> 00:05:56,440 containing genetic material, RNA or DNA. 111 00:05:58,040 --> 00:06:00,280 They can move around and replicate. 112 00:06:02,200 --> 00:06:04,960 Viruses are completely different. 113 00:06:05,040 --> 00:06:06,920 In the universe, there are some mysteries 114 00:06:07,000 --> 00:06:09,320 that have actually personally made me kind of pause 115 00:06:09,400 --> 00:06:10,520 and given me goosebumps. 116 00:06:10,600 --> 00:06:13,000 And strangely enough, one of them is viruses. 117 00:06:14,240 --> 00:06:18,360 The mystery is how viruses can have so much impact on the world, 118 00:06:18,440 --> 00:06:21,840 despite their tiny size and apparent simplicity. 119 00:06:23,960 --> 00:06:26,640 Most are just a strand of genetic material, 120 00:06:26,720 --> 00:06:29,720 sometimes encased in a shell of protein. 121 00:06:30,960 --> 00:06:32,160 Compared to bacteria, 122 00:06:32,240 --> 00:06:34,440 which behave kind of like other normal cells 123 00:06:34,520 --> 00:06:39,200 that we're used to to some degree, viruses are very strange. 124 00:06:39,280 --> 00:06:41,360 We don't really understand viruses. 125 00:06:41,440 --> 00:06:43,920 We don't even know if they're alive or not. 126 00:06:44,000 --> 00:06:46,680 The question are viruses alive 127 00:06:46,760 --> 00:06:50,280 is actually more difficult to answer than you might think. 128 00:06:50,360 --> 00:06:54,880 What is the definition of life? What does it mean to be alive? 129 00:06:55,920 --> 00:06:59,960 NASA's definition of life is a self-sustained chemical system 130 00:07:00,040 --> 00:07:02,040 capable of Darwinian evolution. 131 00:07:03,160 --> 00:07:06,560 Entities that feed, make energy and reproduce. 132 00:07:07,600 --> 00:07:09,760 Viruses can't do that on their own. 133 00:07:09,840 --> 00:07:12,360 They have to have a host cell to do that. 134 00:07:12,440 --> 00:07:15,200 They have the genetic material that they need, 135 00:07:15,280 --> 00:07:16,760 but none of the machinery. 136 00:07:16,840 --> 00:07:20,160 So they really have to infect a host. 137 00:07:20,240 --> 00:07:21,720 If not, they're useless. 138 00:07:23,240 --> 00:07:25,280 Inside a host's body, 139 00:07:25,360 --> 00:07:27,680 viruses latch on to the surface of cells... 140 00:07:29,560 --> 00:07:31,480 ..and then take control. 141 00:07:31,560 --> 00:07:36,880 A virus's life cycle is effectively to hack another cell. 142 00:07:36,960 --> 00:07:38,920 They have to inject that genetic material 143 00:07:39,000 --> 00:07:40,000 into a living cell. 144 00:07:40,080 --> 00:07:41,440 And then the cell is hijacked 145 00:07:41,520 --> 00:07:43,560 and starts making copies of the virus. 146 00:07:43,640 --> 00:07:47,000 Which then have to burst out of this cell, 147 00:07:47,080 --> 00:07:51,760 almost literally like that gory, grotesque scene in Aliens. 148 00:07:51,840 --> 00:07:53,800 They burst out from the inside. 149 00:07:53,880 --> 00:07:57,200 That's like a sailor level horror movie. 150 00:07:58,720 --> 00:08:01,480 This method of replicating is chilling. 151 00:08:02,720 --> 00:08:06,120 It doesn't answer the question of whether they're alive. 152 00:08:08,320 --> 00:08:12,200 That uncertainty may influence our search for life in space. 153 00:08:13,720 --> 00:08:16,080 One of the interesting things to think about 154 00:08:16,160 --> 00:08:19,760 is if we found a virus on another planetary surface, 155 00:08:19,840 --> 00:08:21,560 would we classify that as life? 156 00:08:21,640 --> 00:08:23,600 Would we say that we have found life? 157 00:08:23,680 --> 00:08:25,440 We don't know. 158 00:08:25,520 --> 00:08:30,280 But space viruses could be a sign of other extra-terrestrial life forms. 159 00:08:31,320 --> 00:08:34,000 Viruses have to have a host cell to replicate. 160 00:08:34,080 --> 00:08:38,000 So if you find a virus, in essence, you've found life. 161 00:08:39,240 --> 00:08:42,600 Viruses might lead us to extra-terrestrial life. 162 00:08:42,680 --> 00:08:46,120 Now, new research suggests that life on Earth 163 00:08:46,200 --> 00:08:48,640 may have come from space, 164 00:08:48,720 --> 00:08:52,440 brought to us in a cosmic bombardment 165 00:08:52,520 --> 00:08:53,840 when our planet was young. 166 00:09:00,640 --> 00:09:05,040 We find the microcosmos in every feature of Earth. 167 00:09:05,120 --> 00:09:09,040 But where did this strange kingdom of the very small come from? 168 00:09:09,120 --> 00:09:12,920 Some of its members are so weird they look like aliens. 169 00:09:13,000 --> 00:09:15,320 Could they have come from space? 170 00:09:16,360 --> 00:09:19,280 There's this idea that microbes could have hitched a ride 171 00:09:19,360 --> 00:09:22,520 on a chunk of an asteroid that would fall to Earth. 172 00:09:22,600 --> 00:09:24,760 They could form on a different planet, 173 00:09:24,840 --> 00:09:26,320 something hits that planet, 174 00:09:26,400 --> 00:09:28,480 the rock that they're sitting on gets lifted, 175 00:09:28,560 --> 00:09:31,080 and then hits the Earth as a meteorite. 176 00:09:31,160 --> 00:09:34,640 The idea of hitchhiking bugs sounds a bit wild. 177 00:09:34,720 --> 00:09:37,920 But we have found chunks of Mars on Earth. 178 00:09:38,960 --> 00:09:42,040 Perhaps these space rocks brought life. 179 00:09:42,120 --> 00:09:45,080 It's not completely ridiculous. 180 00:09:45,160 --> 00:09:47,800 We know that rocks, for example, could come form Mars 181 00:09:47,880 --> 00:09:48,880 and land on Earth. 182 00:09:48,960 --> 00:09:50,840 A giant asteroid impact on Mars 183 00:09:50,920 --> 00:09:53,480 could blow shrapnel into space that could land on Earth. 184 00:09:54,800 --> 00:09:58,360 To learn how, we must return to the early solar system, 185 00:09:58,440 --> 00:10:00,760 4.5 billion years ago. 186 00:10:00,840 --> 00:10:04,640 Many infant planets orbit a new star, our sun. 187 00:10:05,840 --> 00:10:08,320 This infant solar system is chaotic. 188 00:10:08,400 --> 00:10:11,200 Collisions between planets are inevitable. 189 00:10:12,240 --> 00:10:15,560 The early solar system was like a pinball machine. 190 00:10:15,640 --> 00:10:17,840 Stuff was hitting, knocking stuff off, 191 00:10:17,920 --> 00:10:20,400 that would land somewhere and knock stuff off. 192 00:10:20,480 --> 00:10:23,480 The young Mars is in the line of fire. 193 00:10:23,560 --> 00:10:28,280 It already has primitive oceans and perhaps primitive life. 194 00:10:29,400 --> 00:10:32,720 A huge space rock smashes into the surface. 195 00:10:33,960 --> 00:10:36,760 We call the event the Borealis Impact. 196 00:10:36,840 --> 00:10:41,160 It blows quadrillion tons of rock into space. 197 00:10:41,240 --> 00:10:45,800 It's not crazy to think that one of these chunks of rock 198 00:10:45,880 --> 00:10:49,160 travelling through our solar system had some hitchhikers on board. 199 00:10:49,240 --> 00:10:51,640 If there's some microbe riding on an asteroid 200 00:10:51,720 --> 00:10:55,360 that got blasted off of Mars, I kinda feel sorry for it, right? 201 00:10:55,440 --> 00:10:57,760 It's just living there on Mars 202 00:10:57,840 --> 00:11:00,160 doing whatever little Martian microbes do 203 00:11:00,240 --> 00:11:03,400 and then a giant impact ejects this thing into space. 204 00:11:05,160 --> 00:11:09,440 In order to get from one planet to another, 205 00:11:09,520 --> 00:11:12,680 a cell would have to run a gauntlet. 206 00:11:12,760 --> 00:11:16,520 It's almost like winning a survival game show. 207 00:11:16,600 --> 00:11:20,400 You've got to survive being blasted off your home world. 208 00:11:20,480 --> 00:11:24,360 You've then got to survive the interplanetary journey 209 00:11:24,440 --> 00:11:26,600 inside a small lump of rock, 210 00:11:26,680 --> 00:11:29,680 being exposed to the vacuum of outer space, 211 00:11:29,760 --> 00:11:34,800 to cosmic rays, to UV radiation, being dried out and frozen. 212 00:11:34,880 --> 00:11:38,280 So the idea of moving life around the solar system 213 00:11:38,360 --> 00:11:43,360 or around the galaxy on asteroids poses a lot of different challenges. 214 00:11:44,400 --> 00:11:48,720 Events like the Borealis Impact ejected so much rock from Mars, 215 00:11:48,800 --> 00:11:51,440 there were lots of opportunities for hitchhiking bugs 216 00:11:51,520 --> 00:11:54,080 to run the gauntlet of space. 217 00:11:54,160 --> 00:11:56,960 But could they survive the journey? 218 00:11:58,200 --> 00:12:01,840 To find out, astronauts on the International Space Station 219 00:12:01,920 --> 00:12:05,920 grew simple bacteria outside in space. 220 00:12:07,800 --> 00:12:11,960 After a year of being in open space, 221 00:12:12,040 --> 00:12:15,520 miraculously some of these microbes survived. 222 00:12:15,600 --> 00:12:16,840 It's incredible. 223 00:12:16,920 --> 00:12:19,320 These microbes just could not be killed, 224 00:12:19,400 --> 00:12:20,640 even though they were in 225 00:12:20,720 --> 00:12:22,880 the worst possible environment for life. 226 00:12:24,000 --> 00:12:25,800 The mission, therefore, shows us 227 00:12:25,880 --> 00:12:30,280 that life can survive the environment in outer space. 228 00:12:30,360 --> 00:12:33,880 Life could be transferred between planets. 229 00:12:33,960 --> 00:12:38,280 Maybe life did get started on Mars, on our next-door neighbour planet, 230 00:12:38,360 --> 00:12:42,440 and then was transferred here inside a meteorite. 231 00:12:42,520 --> 00:12:45,880 Maybe we are immigrants from Mars. 232 00:12:45,960 --> 00:12:49,600 Hitchhiking bugs may have arrived on Earth 233 00:12:49,680 --> 00:12:52,400 and kickstarted the microcosmos. 234 00:12:52,480 --> 00:12:55,360 But now, recent studies of meteorites 235 00:12:55,440 --> 00:12:59,520 suggest that even if living microbes didn't make the journey, 236 00:12:59,600 --> 00:13:02,800 the building blocks that made them did. 237 00:13:04,400 --> 00:13:08,040 In November 2019, an international research team 238 00:13:08,120 --> 00:13:10,760 found an organic molecule called ribose 239 00:13:10,840 --> 00:13:13,240 in meteorites that had crashed on Earth. 240 00:13:14,360 --> 00:13:17,320 Ribose is a sugar. 241 00:13:17,400 --> 00:13:19,040 It's a simple sugar, 242 00:13:19,120 --> 00:13:23,280 but it is a sugar that is absolutely crucial 243 00:13:23,360 --> 00:13:26,160 to all life on Earth. 244 00:13:26,240 --> 00:13:29,960 Ribose is the sugar that makes up RNA, 245 00:13:30,040 --> 00:13:35,480 and RNA sits right in the lynchpin of every cell. 246 00:13:36,520 --> 00:13:39,240 RNA is a simple form of genetic material 247 00:13:39,320 --> 00:13:41,880 that controls cellular function. 248 00:13:41,960 --> 00:13:45,120 It's found in most primitive creatures. 249 00:13:45,200 --> 00:13:48,200 Finding ribose on a meteorite 250 00:13:48,280 --> 00:13:53,120 is so important for us to understand the origins of the microcosmos, 251 00:13:53,200 --> 00:13:55,000 because these are the building blocks. 252 00:13:55,080 --> 00:13:58,320 These are the things that it needs to get started. 253 00:13:58,400 --> 00:14:02,160 So understanding where these building blocks come from 254 00:14:02,240 --> 00:14:05,040 allows us to understand 255 00:14:05,120 --> 00:14:09,000 how the microcosmos might have evolved and started. 256 00:14:10,400 --> 00:14:11,480 The Rosetta Mission 257 00:14:11,560 --> 00:14:15,200 found another building block for life out in space. 258 00:14:15,280 --> 00:14:18,600 A form of phosphorous on the comet 67P. 259 00:14:19,640 --> 00:14:20,800 This was astounding. 260 00:14:20,880 --> 00:14:25,120 - Comet 67 - P was formed at the birth of the solar system, 261 00:14:25,200 --> 00:14:27,440 4.67 billion years ago. 262 00:14:27,520 --> 00:14:29,520 And it hasn't changed since then. 263 00:14:29,600 --> 00:14:33,800 It's a time capsule from the birth of the sun and the planets. 264 00:14:33,880 --> 00:14:37,040 And it's been in the deep freeze ever since. 265 00:14:37,120 --> 00:14:41,440 So these forms of phosphorous that we found on comet 67P 266 00:14:41,520 --> 00:14:45,400 tell us what was available at the time the Earth was forming 267 00:14:45,480 --> 00:14:49,680 and then when life was getting started on primordial Earth. 268 00:14:50,720 --> 00:14:53,200 The early solar system contained many chemicals 269 00:14:53,280 --> 00:14:54,360 needed for life. 270 00:14:55,560 --> 00:14:56,880 It's an important discovery 271 00:14:56,960 --> 00:14:59,520 because it means that these compounds were around 272 00:14:59,600 --> 00:15:01,480 when the solar system was forming. 273 00:15:01,560 --> 00:15:03,440 So they would have been readily available 274 00:15:03,520 --> 00:15:07,960 for life to tap into and use to start forming cellular structure. 275 00:15:09,160 --> 00:15:13,560 These discoveries not only show that essential chemicals came to Earth, 276 00:15:13,640 --> 00:15:16,520 but that they exist throughout the solar system. 277 00:15:17,560 --> 00:15:21,040 We tend to think of the microcosmos as only existing on Earth, 278 00:15:21,120 --> 00:15:23,760 in the sense that only Earth has these building blocks. 279 00:15:23,840 --> 00:15:27,840 But now these new observations suggest that a microcosmos, 280 00:15:27,920 --> 00:15:29,640 at least the building blocks for one, 281 00:15:29,720 --> 00:15:33,320 could exist beyond Earth and throughout the solar system. 282 00:15:35,640 --> 00:15:36,640 We got evidence 283 00:15:36,720 --> 00:15:41,360 for the widespread distribution of these building blocks in 2017. 284 00:15:42,880 --> 00:15:48,000 A strange space rock called Oumuamua raced through the solar system. 285 00:15:49,080 --> 00:15:51,320 The weird thing about Oumuamua 286 00:15:51,400 --> 00:15:56,360 is that it's clearly on a trajectory that came from deep space, 287 00:15:56,440 --> 00:15:58,000 interstellar space. 288 00:15:58,080 --> 00:16:00,840 That it literally came from another star. 289 00:16:01,880 --> 00:16:05,120 Even weirder, its colour. Its surface is red. 290 00:16:06,160 --> 00:16:08,120 And so that raised a lot of questions 291 00:16:08,200 --> 00:16:09,920 about what its composition could be. 292 00:16:10,000 --> 00:16:11,800 And one possibility 293 00:16:11,880 --> 00:16:14,960 is that it's actually filled with organic materials 294 00:16:15,040 --> 00:16:16,760 which tend to have those colours, 295 00:16:16,840 --> 00:16:19,520 especially when exposed to the space environment. 296 00:16:19,600 --> 00:16:22,240 This suggests organic materials 297 00:16:22,320 --> 00:16:25,120 may travel through interstellar space. 298 00:16:25,200 --> 00:16:27,000 I think it's entirely reasonable 299 00:16:27,080 --> 00:16:29,800 that we could be getting organic materials 300 00:16:29,880 --> 00:16:33,720 that are the building blocks of life from outside of our solar system. 301 00:16:33,800 --> 00:16:36,960 There may be a molecular transport system 302 00:16:37,040 --> 00:16:38,600 throughout the galaxy. 303 00:16:38,680 --> 00:16:40,160 We could be receiving stuff 304 00:16:40,240 --> 00:16:42,640 from other bodies in our solar system 305 00:16:42,720 --> 00:16:44,920 and from bodies outside our solar system, 306 00:16:45,000 --> 00:16:47,400 because stuff is moving around. 307 00:16:47,480 --> 00:16:49,840 Oumuamua is just the tip of the iceberg. 308 00:16:49,920 --> 00:16:52,640 There are probably lots of interstellar visitors 309 00:16:52,720 --> 00:16:54,800 passing through our solar system all the time. 310 00:16:56,000 --> 00:16:58,640 Comets and asteroids may have brought chemicals 311 00:16:58,720 --> 00:17:00,560 to kickstart the microcosmos. 312 00:17:03,240 --> 00:17:07,960 Now, explosive new research suggests that space rocks hitting Earth 313 00:17:08,040 --> 00:17:09,200 did even more. 314 00:17:10,280 --> 00:17:14,760 Could the violent impacts themselves have helped life get started. 315 00:17:25,400 --> 00:17:29,640 How did the microcosmos and life on Earth start? 316 00:17:29,720 --> 00:17:32,760 Did asteroids and comets deliver the building blocks, 317 00:17:33,880 --> 00:17:37,200 phosphorous, ribose and other organic compounds? 318 00:17:37,280 --> 00:17:39,840 Or did they start life in other ways? 319 00:17:39,920 --> 00:17:44,400 New research suggests the impact of crashing space rocks 320 00:17:44,480 --> 00:17:46,680 could have provided the spark for life. 321 00:17:47,760 --> 00:17:49,000 The force of the impact 322 00:17:49,080 --> 00:17:52,400 actually triggered the creation of these molecules 323 00:17:52,480 --> 00:17:54,480 that are the building blocks of life. 324 00:17:58,560 --> 00:18:02,720 The energy from the impact breaks down and reforms molecules 325 00:18:02,800 --> 00:18:04,520 into new compounds. 326 00:18:04,600 --> 00:18:07,160 You can actually strip apart atoms and molecules, 327 00:18:07,240 --> 00:18:09,240 recombine them in more complex ways, 328 00:18:09,320 --> 00:18:12,360 and make the stuff of life in an impact. 329 00:18:13,400 --> 00:18:14,720 Over millions of years, 330 00:18:14,800 --> 00:18:18,200 complex organic materials fill Earth's oceans. 331 00:18:19,280 --> 00:18:22,440 Then, around 3.5 billion years ago, 332 00:18:22,520 --> 00:18:25,320 the process that kickstarted life began. 333 00:18:26,760 --> 00:18:30,640 Going back to the origins of life on Earth, it was a process. 334 00:18:30,720 --> 00:18:32,440 You began with large molecules 335 00:18:32,520 --> 00:18:36,080 that almost accidentally began to make copies of themselves. 336 00:18:36,160 --> 00:18:38,520 These became the first genetic material. 337 00:18:38,600 --> 00:18:41,360 Some of these larger molecules bound together 338 00:18:41,440 --> 00:18:44,000 and became the first sort of protocells. 339 00:18:44,080 --> 00:18:47,240 A protocell could represent 340 00:18:47,320 --> 00:18:52,840 this earliest pre-life stage of evolution. 341 00:18:54,640 --> 00:18:59,440 Protocells lack the full chemical machinery of modern cells. 342 00:18:59,520 --> 00:19:01,320 They're a simple cell membrane, 343 00:19:01,400 --> 00:19:05,360 surrounding a glob of genetic material like RNA, 344 00:19:05,440 --> 00:19:07,760 built from ribose and phosphorous. 345 00:19:08,800 --> 00:19:10,600 Now you have a barrier. 346 00:19:10,680 --> 00:19:13,680 Now you can actually control which chemicals come into the cell 347 00:19:13,760 --> 00:19:14,760 and which go out, 348 00:19:14,840 --> 00:19:19,600 and you protect the genetic code intact inside the cell. 349 00:19:19,680 --> 00:19:23,640 Once that happened, evolution began to run with it. 350 00:19:23,720 --> 00:19:27,640 These simple cells grew more and more complicated, 351 00:19:27,720 --> 00:19:32,720 until, shazam, you get all life on Earth. 352 00:19:32,800 --> 00:19:35,440 All cellular life anyway. 353 00:19:35,520 --> 00:19:40,080 Unlike bacteria, viruses are not cells, 354 00:19:40,160 --> 00:19:43,720 Scientists debate if they are even living things. 355 00:19:43,800 --> 00:19:47,200 So, how then do viruses fit into the birth of life? 356 00:19:47,280 --> 00:19:49,840 Viruses aren't really thought of 357 00:19:49,920 --> 00:19:52,480 as playing a role in our evolutionary history, 358 00:19:52,560 --> 00:19:54,440 but we're just beginning to understand 359 00:19:54,520 --> 00:19:56,200 that that's simply not the case. 360 00:19:56,280 --> 00:19:58,080 What if viruses themselves 361 00:19:58,160 --> 00:20:00,960 were an essential cog in the machinery of life? 362 00:20:02,040 --> 00:20:06,480 How can we investigate if viruses helped life on Earth develop? 363 00:20:06,560 --> 00:20:09,080 They don't leave many clues about their past. 364 00:20:10,360 --> 00:20:15,240 The hard thing with understanding the evolutionary history of viruses 365 00:20:15,320 --> 00:20:17,200 is they don't leave a fossil record. 366 00:20:17,280 --> 00:20:20,680 There's no geology that we can go back and dig up, 367 00:20:20,760 --> 00:20:24,240 and say, "Aha! This is when viruses first came about." 368 00:20:25,880 --> 00:20:30,280 We don't know when viruses entered the evolutionary game of life. 369 00:20:31,480 --> 00:20:34,720 Was it near the beginning or a little bit later? 370 00:20:34,800 --> 00:20:37,600 There is this crazy idea that viruses 371 00:20:37,680 --> 00:20:40,280 might actually have come first in the tree of life. 372 00:20:40,360 --> 00:20:43,000 When you think about the real origins of life, 373 00:20:43,080 --> 00:20:45,480 it had to start with something that simple. 374 00:20:45,560 --> 00:20:48,880 Something that was just a molecule that could start replicating. 375 00:20:48,960 --> 00:20:52,760 A virus may be our best example of that transition 376 00:20:52,840 --> 00:20:56,160 from just complex chemistry to the beginnings of life. 377 00:20:57,200 --> 00:20:59,520 In this scenario, chemicals floating 378 00:20:59,600 --> 00:21:02,160 in the three-and-a-half billion year old oceans 379 00:21:02,240 --> 00:21:06,040 formed a shell of protein around some simple genetic material. 380 00:21:07,480 --> 00:21:11,800 But did viruses evolve before anything else? 381 00:21:11,880 --> 00:21:15,600 The flaw in the virus first hypothesis 382 00:21:15,680 --> 00:21:20,680 is that a virus has to have a host organism to replicate. 383 00:21:20,760 --> 00:21:24,560 So, without a host, how does the virus replicate? 384 00:21:24,640 --> 00:21:27,280 And this is the question we have to ask ourselves 385 00:21:27,360 --> 00:21:30,880 when we think of viruses coming first on the evolutionary tree. 386 00:21:32,080 --> 00:21:35,560 Modern viruses can't replicate without a host. 387 00:21:35,640 --> 00:21:38,880 It's likely that ancient viruses couldn't either. 388 00:21:39,960 --> 00:21:44,280 But could early cells and viruses have joined forces 389 00:21:44,360 --> 00:21:46,440 in a way that benefitted them both? 390 00:21:46,520 --> 00:21:51,320 Some new theories are suggesting that viruses and cellular life 391 00:21:51,400 --> 00:21:54,960 co-evolved and actually helped each other out, 392 00:21:55,040 --> 00:21:59,760 and potentially even helped out the evolution of human life. 393 00:21:59,840 --> 00:22:03,160 How did this co-evolution work? 394 00:22:03,240 --> 00:22:05,160 We know that viruses today 395 00:22:05,240 --> 00:22:08,880 inject their genetic material into cells to manipulate them. 396 00:22:09,920 --> 00:22:14,000 Perhaps early viruses manipulated the genes of the first cells 397 00:22:14,080 --> 00:22:15,720 the same way. 398 00:22:15,800 --> 00:22:17,800 Think of this primordial soup, 399 00:22:17,880 --> 00:22:22,120 and the genes, the RNA, that's in this primordial soup, 400 00:22:22,200 --> 00:22:25,360 being swapped between organisms, kind of like a swap meet. 401 00:22:25,440 --> 00:22:27,360 You bring something you don't need any more 402 00:22:27,440 --> 00:22:29,560 and you pass it along to somebody else. 403 00:22:29,640 --> 00:22:33,120 So, in this way, organisms sharing their genetic material 404 00:22:33,200 --> 00:22:34,440 back and forth, 405 00:22:34,520 --> 00:22:37,120 offers a competitive advantage to each one. 406 00:22:37,200 --> 00:22:41,840 The virus might break off bits of the host's genetic material 407 00:22:41,920 --> 00:22:43,320 and mix it with their own. 408 00:22:44,480 --> 00:22:46,480 When the virus attacks another cell, 409 00:22:46,560 --> 00:22:50,280 it could pass on the mixed genes to its next host. 410 00:22:51,320 --> 00:22:56,480 In this sense, then, viruses help stir things up. 411 00:22:56,560 --> 00:23:00,960 They shuttle genes between widely different organisms 412 00:23:01,040 --> 00:23:05,280 and therefore help drive evolution itself. 413 00:23:05,360 --> 00:23:08,360 Now, probably almost all of these injections did nothing useful 414 00:23:08,440 --> 00:23:10,000 and maybe even killed the cell. 415 00:23:10,080 --> 00:23:13,400 But if one in a million injection changed something for the better, 416 00:23:13,480 --> 00:23:16,640 made it more complex, made it more able to survive, 417 00:23:16,720 --> 00:23:19,280 then that cell reproduced even more. 418 00:23:19,360 --> 00:23:24,000 If virally-enhanced cells thrived in the primeval oceans, 419 00:23:24,080 --> 00:23:27,920 over time, they might have evolved into more complex creatures, 420 00:23:28,000 --> 00:23:30,400 and eventually into us. 421 00:23:30,480 --> 00:23:32,360 What's so crazy is to think about the fact 422 00:23:32,440 --> 00:23:35,000 that we actually could be descended from viruses. 423 00:23:35,080 --> 00:23:37,720 I am sure that a lot of my genetic code 424 00:23:37,800 --> 00:23:40,880 originally came from the injection of a virus. 425 00:23:40,960 --> 00:23:44,600 I love the idea that I might be descendent from a virus. 426 00:23:44,680 --> 00:23:47,160 Just coming from something that simple 427 00:23:47,240 --> 00:23:50,040 and evolving into something this complex 428 00:23:50,120 --> 00:23:52,280 is just a feat of nature. 429 00:23:52,360 --> 00:23:55,920 Viruses played a major part in human evolution. 430 00:23:56,000 --> 00:24:00,720 Around 8% of human DNA came from ancient viral infections. 431 00:24:00,800 --> 00:24:04,440 In fact, without them, we wouldn't be human. 432 00:24:05,640 --> 00:24:09,720 In our brains, we actually have relic viral DNA, 433 00:24:09,800 --> 00:24:12,360 so DNA that came from a virus. 434 00:24:12,440 --> 00:24:14,080 But this helps us. 435 00:24:14,160 --> 00:24:17,640 Without this, we don't think we would have consciousness. 436 00:24:19,000 --> 00:24:21,200 We also think that viral DNA 437 00:24:21,280 --> 00:24:24,600 helped us develop an immune system to fight off infection 438 00:24:24,680 --> 00:24:28,400 and gave us the ability to digest starch. 439 00:24:30,080 --> 00:24:33,320 The microcosmos has guided our evolution. 440 00:24:33,400 --> 00:24:35,960 It even created the air we breathe. 441 00:24:36,040 --> 00:24:40,840 But in doing so, it also triggered the largest mass extinction 442 00:24:40,920 --> 00:24:43,080 the Earth has ever seen. 443 00:24:47,200 --> 00:24:50,760 Planet Earth, 2.5 billion years ago. 444 00:24:51,800 --> 00:24:55,280 The microcosmos colonises Earth's oceans. 445 00:24:56,320 --> 00:24:59,640 This is not a world we would recognise today. 446 00:25:00,800 --> 00:25:03,800 If you were to travel back in time, just on Earth, 447 00:25:03,880 --> 00:25:06,680 to see what it was like 2.5 billion years ago, 448 00:25:06,760 --> 00:25:09,920 it would look really different in many ways. 449 00:25:10,000 --> 00:25:13,480 There were oceans and they had life in those oceans, 450 00:25:13,560 --> 00:25:17,720 but there weren't any land plants or land animals. 451 00:25:17,800 --> 00:25:19,440 It was just bare rock. 452 00:25:19,520 --> 00:25:20,720 So, to think about it, 453 00:25:20,800 --> 00:25:23,440 a human going back in time to visit the really early Earth, 454 00:25:23,520 --> 00:25:26,400 they would find an utterly inhospitable planet. 455 00:25:26,480 --> 00:25:28,120 As a human, you'd be out of luck 456 00:25:28,200 --> 00:25:31,240 because there was no oxygen in the atmosphere at that time, 457 00:25:31,320 --> 00:25:33,040 so hopefully you brought a spacesuit. 458 00:25:34,160 --> 00:25:35,640 The atmosphere was fine 459 00:25:35,720 --> 00:25:39,280 for the billions of inhabitants of the early microcosmos. 460 00:25:40,360 --> 00:25:42,000 They were very slow-paced 461 00:25:42,080 --> 00:25:45,520 and they did everything they did without any oxygen in the air. 462 00:25:45,600 --> 00:25:49,320 But this tranquil existence was about to change. 463 00:25:50,360 --> 00:25:53,400 For a long time, conditions on Earth were fairly static. 464 00:25:53,480 --> 00:25:55,960 But then about two-and-a-half billion years ago, 465 00:25:56,040 --> 00:25:59,400 an evolutionary glitch changed everything. 466 00:26:00,480 --> 00:26:05,120 A clue to that glitch rests in strange rocky mounds. 467 00:26:05,200 --> 00:26:06,960 Stromatolites. 468 00:26:08,080 --> 00:26:12,600 Stromatolites are almost like microbial cities. 469 00:26:12,680 --> 00:26:16,080 If you zoom down on to their scale, 470 00:26:16,160 --> 00:26:20,320 you'll see layer upon layer of bacteria, 471 00:26:20,400 --> 00:26:23,200 almost like the high-rise skyscrapers 472 00:26:23,280 --> 00:26:25,400 of one of our cities. 473 00:26:25,480 --> 00:26:30,320 The microcosmic high-rises are full of cyanobacteria. 474 00:26:30,400 --> 00:26:33,200 These bacteria can photosynthesise. 475 00:26:34,240 --> 00:26:36,720 Photosynthesis is a chemical reaction 476 00:26:36,800 --> 00:26:40,040 that takes place inside a plant, producing food. 477 00:26:41,320 --> 00:26:44,520 Today, it's an important part of our planet's existence. 478 00:26:45,760 --> 00:26:49,480 Two-and-a-half billion years ago, it was revolutionary. 479 00:26:50,840 --> 00:26:53,640 And it happened when ancient cyanobacteria 480 00:26:53,720 --> 00:26:56,720 similar to those in the stromatolites mutated. 481 00:26:57,880 --> 00:27:02,600 This mutation allowed Cyanobacteria to take the energy from sunlight 482 00:27:02,680 --> 00:27:06,400 and use it to make sugars out of water and carbon dioxide. 483 00:27:06,480 --> 00:27:12,040 This gave cyanobacteria a huge evolutionary edge. 484 00:27:12,120 --> 00:27:14,680 They could now make more energy for themselves, 485 00:27:14,760 --> 00:27:17,400 so they could grow and reproduce faster. 486 00:27:18,560 --> 00:27:21,720 For everything else, it was a catastrophe. 487 00:27:21,800 --> 00:27:25,360 It produced oxygen as a waste produce. 488 00:27:25,440 --> 00:27:29,000 Oxygen was no use to them, so they released it into the air, 489 00:27:29,080 --> 00:27:33,000 transforming Earth's atmosphere over millions of years. 490 00:27:33,080 --> 00:27:36,960 This by-product, oxygen, is extremely toxic. 491 00:27:38,080 --> 00:27:41,880 The reason oxygen is so dangerous is that it's very reactive. 492 00:27:41,960 --> 00:27:44,200 It loves to combine with everything. 493 00:27:44,280 --> 00:27:46,280 So, think about something rusting. 494 00:27:46,360 --> 00:27:48,160 Iron rusts because oxygen 495 00:27:48,240 --> 00:27:50,320 is actually combining with the molecules. 496 00:27:50,400 --> 00:27:52,120 It's called oxidation. 497 00:27:52,200 --> 00:27:56,600 So when oxygen was first released, it was tremendously dangerous. 498 00:27:56,680 --> 00:27:59,720 The new oxygen builds up in the atmosphere, 499 00:27:59,800 --> 00:28:03,960 killing off species of microbes everywhere on the planet. 500 00:28:04,040 --> 00:28:05,520 Right when this happened, 501 00:28:05,600 --> 00:28:08,480 you would have had a mass extinction. 502 00:28:08,560 --> 00:28:12,120 This would've been a global mass extinction event. 503 00:28:12,200 --> 00:28:15,680 This was an unprecedented environmental disaster 504 00:28:15,760 --> 00:28:18,520 probably in the entire history of the Earth up to that point, 505 00:28:18,600 --> 00:28:20,560 and I'm not even sure it's been paralleled 506 00:28:20,640 --> 00:28:21,720 even up to today. 507 00:28:21,800 --> 00:28:24,120 This may have been the single biggest catastrophe 508 00:28:24,200 --> 00:28:26,120 in our planet's history. 509 00:28:26,200 --> 00:28:28,360 This was the great oxidation event, 510 00:28:28,440 --> 00:28:31,840 and it changed our atmosphere, it changed our planet, 511 00:28:31,920 --> 00:28:34,120 and it didn't just end there. 512 00:28:34,200 --> 00:28:35,840 Something changed again. 513 00:28:35,920 --> 00:28:39,640 Another mutation allowed some of these bacteria 514 00:28:39,720 --> 00:28:43,360 to use that oxygen in their own metabolism. 515 00:28:43,440 --> 00:28:46,520 And that was a huge change. 516 00:28:48,160 --> 00:28:51,720 The ability to use oxygen was an incredible leap forward. 517 00:28:52,960 --> 00:28:56,840 The beauty of oxygen is that it allows the metabolism 518 00:28:56,920 --> 00:29:00,240 to process nutrients much more rapidly. 519 00:29:00,320 --> 00:29:03,960 It basically helps bodies burn these materials, 520 00:29:04,040 --> 00:29:06,040 so that they can generate a lot more energy 521 00:29:06,120 --> 00:29:07,520 a lot more quickly. 522 00:29:07,600 --> 00:29:11,320 Organisms that figured out how to use oxygen for respiration 523 00:29:11,400 --> 00:29:13,800 ended up getting a huge kickstart of energy 524 00:29:13,880 --> 00:29:17,000 and gave 'em a huge advantage over other organisms. 525 00:29:17,080 --> 00:29:21,880 It supplied enough energy that organisms could become more complex, 526 00:29:21,960 --> 00:29:24,360 larger, multi-cellular. 527 00:29:24,440 --> 00:29:30,040 Really the tapping into oxygen and being able to use oxygen 528 00:29:30,120 --> 00:29:33,800 in our metabolism meant that it was a game changer, 529 00:29:33,880 --> 00:29:37,360 that we could evolve in ways that never would've been possible 530 00:29:37,440 --> 00:29:39,280 without cyanobacteria. 531 00:29:40,400 --> 00:29:43,400 Simple organisms became more complex. 532 00:29:43,480 --> 00:29:46,880 Single-celled creatures became multicellular. 533 00:29:47,920 --> 00:29:51,800 This gradual accumulation of oxygen into the atmosphere of the Earth 534 00:29:51,880 --> 00:29:55,760 was huge for the multi-cellular animal and life explosion 535 00:29:55,840 --> 00:29:57,840 that occurred as a result, 536 00:29:57,920 --> 00:29:59,840 and was one of the most important events 537 00:29:59,920 --> 00:30:00,920 in Earth's history. 538 00:30:01,000 --> 00:30:03,880 This would've been a complete transformation 539 00:30:03,960 --> 00:30:06,640 of the Earth's atmosphere and physical setting. 540 00:30:06,720 --> 00:30:10,520 This is when the green Earth started to evolve. 541 00:30:10,600 --> 00:30:14,400 The great oxidation event changed the course of evolution, 542 00:30:14,480 --> 00:30:16,880 leading to our complex world. 543 00:30:18,720 --> 00:30:22,640 It is really hard to overemphasise the importance of the microcosmos. 544 00:30:22,720 --> 00:30:26,160 Just the fact that I'm speaking to you, I'm breathing in and out. 545 00:30:26,240 --> 00:30:27,320 I wouldn't be doing that 546 00:30:27,400 --> 00:30:29,600 without the tiniest organisms on the planet. 547 00:30:30,880 --> 00:30:33,600 The microcosmos gave us life. 548 00:30:33,680 --> 00:30:36,440 Now it could wipe us out. 549 00:30:36,520 --> 00:30:40,160 Global warming is releasing potentially lethal bacteria 550 00:30:40,240 --> 00:30:41,400 and viruses. 551 00:30:42,800 --> 00:30:46,960 Are we facing a microcosmic zombie apocalypse? 552 00:30:51,720 --> 00:30:53,920 Siberia, present day. 553 00:30:54,000 --> 00:30:58,040 Rising temperatures are melting the Arctic permafrost 554 00:30:58,120 --> 00:31:02,840 revealing land sealed under ice for tens of thousands of years. 555 00:31:03,960 --> 00:31:07,280 As that permafrost begins thawing out and melting 556 00:31:07,360 --> 00:31:08,680 with climate change, 557 00:31:08,760 --> 00:31:11,600 maybe that will release pathogens 558 00:31:11,680 --> 00:31:15,440 that have been locked up for potentially thousands of years. 559 00:31:16,480 --> 00:31:21,200 In 2014, researchers investigated melting Siberian tundra. 560 00:31:22,320 --> 00:31:24,640 A region larger than the USA. 561 00:31:25,720 --> 00:31:27,600 I've seen a lot of science fiction movies 562 00:31:27,680 --> 00:31:29,760 where scientists are digging around in the ice 563 00:31:29,840 --> 00:31:31,800 and find something bad from a long time ago. 564 00:31:31,880 --> 00:31:35,200 Scientists took samples of tundra soil to the lab 565 00:31:35,280 --> 00:31:37,000 and examined the contents. 566 00:31:37,080 --> 00:31:41,160 They found a frozen ancient virus. 567 00:31:41,240 --> 00:31:47,280 A virus locked in ice from over 30,000 years ago. 568 00:31:48,320 --> 00:31:51,960 Isn't this the start of, like, every horror movie? 569 00:31:52,040 --> 00:31:54,920 A scientist uncovers some deep secret of nature 570 00:31:55,000 --> 00:31:59,360 and then just open it up and unleash it on the world. 571 00:32:00,400 --> 00:32:03,400 Just like in a B movie, the team fed the virus 572 00:32:03,480 --> 00:32:07,320 to living single-celled creatures called amoebas 573 00:32:07,400 --> 00:32:09,880 to see if the virus still functioned 574 00:32:09,960 --> 00:32:12,360 after being frozen for thousands of years. 575 00:32:13,400 --> 00:32:18,400 The virus woke up, attacked the amoebas and replicated. 576 00:32:19,440 --> 00:32:21,960 Bringing this ancient virus back to life 577 00:32:22,040 --> 00:32:25,000 was sort of waking up the undead. 578 00:32:26,320 --> 00:32:30,720 Scientists had no idea how this zombie virus would behave. 579 00:32:33,640 --> 00:32:37,160 Something about it was very, very different. 580 00:32:37,240 --> 00:32:40,680 It was huge compared to normal viruses. 581 00:32:40,760 --> 00:32:43,840 It was substantially larger 582 00:32:43,920 --> 00:32:47,360 than any virus that we had seen before. 583 00:32:47,440 --> 00:32:51,880 This is the Goliath of Goliaths among viruses. 584 00:32:52,920 --> 00:32:56,080 So large, it looks more like bacteria than a virus. 585 00:32:57,200 --> 00:33:01,280 We call these kinds of giant viruses mimiviruses 586 00:33:01,360 --> 00:33:05,960 because they mimic other creatures like bacteria. 587 00:33:07,000 --> 00:33:09,080 One way the virus mimics bacteria 588 00:33:09,160 --> 00:33:11,880 is in the amount of its genetic material. 589 00:33:11,960 --> 00:33:14,280 It has 900 genes, 590 00:33:14,360 --> 00:33:17,680 eight times as many as a regular virus. 591 00:33:17,760 --> 00:33:20,320 Viruses are very simple. 592 00:33:20,400 --> 00:33:23,040 They don't require a lot of genes to function. 593 00:33:23,120 --> 00:33:28,920 But this virus has more genes than necessary. 594 00:33:29,000 --> 00:33:32,600 What is it doing with all these extra genes? 595 00:33:32,680 --> 00:33:36,480 We have now found other mimiviruses. 596 00:33:36,560 --> 00:33:38,960 20 years ago, we had no idea 597 00:33:39,040 --> 00:33:41,960 that this complex type of virus even existed. 598 00:33:42,040 --> 00:33:45,280 We still don't know what all the extra genes do. 599 00:33:46,720 --> 00:33:47,880 This type of virus 600 00:33:47,960 --> 00:33:51,120 might even be able to generate its own energy, 601 00:33:51,200 --> 00:33:54,840 making it closer to bacteria than other viruses. 602 00:33:56,080 --> 00:33:59,080 Because it has so many extra genes, 603 00:33:59,160 --> 00:34:02,840 this is a virus that is not acting like a virus. 604 00:34:02,920 --> 00:34:06,720 We can't be sure how the Siberian mimivirus 605 00:34:06,800 --> 00:34:08,960 will behave if released. 606 00:34:09,040 --> 00:34:12,200 And even if it only attacks amoebas, 607 00:34:12,280 --> 00:34:14,960 there could be other large complex viruses 608 00:34:15,040 --> 00:34:16,280 buried in the ice. 609 00:34:17,680 --> 00:34:20,160 They may not be so safe. 610 00:34:20,240 --> 00:34:23,560 We know that there are large regions of the Earth 611 00:34:23,640 --> 00:34:25,640 that are locked in ice right now. 612 00:34:25,720 --> 00:34:30,800 There could be viruses that live inside that ice 613 00:34:30,880 --> 00:34:35,200 that, if the Earth gets too warm, could reactivate. 614 00:34:35,280 --> 00:34:39,360 These viruses could potentially be a threat to us. 615 00:34:40,480 --> 00:34:45,120 Recently, other dangerous frozen zombies have reanimated, 616 00:34:45,200 --> 00:34:47,840 hidden in the dead. 617 00:34:47,920 --> 00:34:49,920 We tend to think of people who died in the past 618 00:34:50,000 --> 00:34:52,400 as not being able to affect us at all, right? 619 00:34:52,480 --> 00:34:54,640 They're gone, their germs are gone. 620 00:34:54,720 --> 00:34:56,880 Unfortunately, this isn't exactly true. 621 00:34:56,960 --> 00:35:01,040 So, for people who are buried in tundra that's been frozen, 622 00:35:01,120 --> 00:35:02,680 they never really disappeared. 623 00:35:02,760 --> 00:35:05,560 And now, unfortunately, as the climate warms, 624 00:35:05,640 --> 00:35:07,360 these tundra environments 625 00:35:07,440 --> 00:35:12,320 are releasing frozen people and animals 626 00:35:12,400 --> 00:35:14,720 who died thousands of years ago. 627 00:35:16,000 --> 00:35:18,960 But it's not the dead people and animals that threaten us. 628 00:35:19,040 --> 00:35:21,360 It's the microbes inside them. 629 00:35:22,640 --> 00:35:26,040 In 2016, that threat became real, 630 00:35:26,120 --> 00:35:29,160 when another area of Siberia thawed. 631 00:35:29,240 --> 00:35:31,880 A 12-year-old boy died 632 00:35:31,960 --> 00:35:35,320 and dozens of people needed medical treatment. 633 00:35:35,400 --> 00:35:38,040 2,000 reindeer also perished. 634 00:35:38,120 --> 00:35:43,440 The culprit? Reanimated bacteria called anthrax 635 00:35:43,520 --> 00:35:45,880 inside a melting reindeer. 636 00:35:45,960 --> 00:35:50,560 Anthrax is a common microbe found in soil. 637 00:35:50,640 --> 00:35:55,040 In medieval times, sometimes farmers would come back 638 00:35:55,120 --> 00:35:58,520 to find entire fields of dead animals. 639 00:35:58,600 --> 00:36:01,000 They didn't understand at the time what was going on. 640 00:36:01,080 --> 00:36:03,960 They attribute it to cursed fields. 641 00:36:04,040 --> 00:36:08,160 But we now know that these were outbreaks of anthrax. 642 00:36:09,200 --> 00:36:12,760 The defrosted reindeer died nearly a century ago. 643 00:36:12,840 --> 00:36:17,400 The anthrax that killed it was safely locked away in the ice. 644 00:36:18,560 --> 00:36:23,720 The thawing out of regions like the Siberian permafrost 645 00:36:23,800 --> 00:36:27,280 could be almost like the inadvertent opening 646 00:36:27,360 --> 00:36:29,160 of Pandora's box. 647 00:36:29,240 --> 00:36:32,000 One you open it, you don't know what's gonna come out. 648 00:36:32,080 --> 00:36:36,720 It could be releasing ancient preserved microbes, 649 00:36:36,800 --> 00:36:41,760 bacteria or viruses that have been laying dormant 650 00:36:41,840 --> 00:36:44,880 for hundreds, if not thousands, of years. 651 00:36:44,960 --> 00:36:48,280 If these microbes are actually very different 652 00:36:48,360 --> 00:36:50,160 from what we have on Earth today, 653 00:36:50,240 --> 00:36:52,560 if we encountered these microbes, 654 00:36:52,640 --> 00:36:54,720 it's not really clear what would happen 655 00:36:54,800 --> 00:36:56,040 with our immune systems. 656 00:36:56,120 --> 00:36:58,600 You know, it could be totally fine. 657 00:36:58,680 --> 00:37:02,040 But it could also wreak complete havoc on us. 658 00:37:02,120 --> 00:37:05,280 It's also not clear if modern drugs 659 00:37:05,360 --> 00:37:09,680 would help us beat any ancient microbes we unleash. 660 00:37:10,720 --> 00:37:15,200 Now, as humanity expands beyond Earth to new worlds, 661 00:37:15,280 --> 00:37:19,360 will we carry our microcosmos with us into space, 662 00:37:19,440 --> 00:37:23,560 or have we already infected our cosmic neighbourhood? 663 00:37:27,880 --> 00:37:32,520 Space is no longer the final frontier of the future. 664 00:37:32,600 --> 00:37:35,000 We're already exploring the solar system. 665 00:37:36,160 --> 00:37:39,960 We've sent probes to the planets and put boots on the moon. 666 00:37:41,240 --> 00:37:46,880 Now NASA plans to land astronauts on Mars by the 2030s. 667 00:37:47,920 --> 00:37:50,160 As a science fiction nerd myself, 668 00:37:50,240 --> 00:37:51,960 without even breaking a sweat, 669 00:37:52,040 --> 00:37:55,280 I could name ten movies where people go to another planet 670 00:37:55,360 --> 00:37:57,520 and some disease, some alien lifeform, 671 00:37:57,600 --> 00:38:00,320 is unleashed on humans and kills us all. 672 00:38:00,400 --> 00:38:02,400 I think that has it exactly backwards. 673 00:38:02,480 --> 00:38:05,200 If we try to settle on other planets, 674 00:38:05,280 --> 00:38:07,240 we have to be really, really careful 675 00:38:07,320 --> 00:38:10,800 and really, really think about how we are affecting them. 676 00:38:10,880 --> 00:38:14,440 As we launch more and more missions into space, 677 00:38:14,520 --> 00:38:18,000 we risk sending Earth's microcosmos with them, 678 00:38:18,080 --> 00:38:20,720 endangering the health of the solar system. 679 00:38:21,760 --> 00:38:25,480 And if we find a planet that actually has its own biosphere, 680 00:38:25,560 --> 00:38:28,560 that has life of its own, we need to be very careful about 681 00:38:28,640 --> 00:38:31,360 how we introduce our microbes to their microbes, 682 00:38:31,440 --> 00:38:33,720 because it could really be catastrophic for them. 683 00:38:33,800 --> 00:38:37,240 It's serious because we're looking at places like Mars, 684 00:38:37,320 --> 00:38:40,680 like Titan, Saturn's moon, like comets, 685 00:38:40,760 --> 00:38:43,920 where life, or at least pre-biotic life, could've existed, 686 00:38:44,000 --> 00:38:48,640 or in the past, there could've been a much more habitable environment. 687 00:38:48,720 --> 00:38:52,320 So it's entirely possible that we are polluting, 688 00:38:52,400 --> 00:38:57,640 we are infecting these other objects with our own bacteria. 689 00:38:57,720 --> 00:39:00,720 If we contaminate a pristine world, 690 00:39:00,800 --> 00:39:03,600 we won't know which microbes were there first. 691 00:39:04,720 --> 00:39:07,800 Our bugs could even kill off the native ones. 692 00:39:08,920 --> 00:39:10,720 It may have already happened. 693 00:39:15,160 --> 00:39:20,800 Is it possible that we've already sent pathogens out among the stars, 694 00:39:20,880 --> 00:39:22,960 hitching rides on our spacecraft? 695 00:39:24,000 --> 00:39:26,000 We've sent missions to other worlds, 696 00:39:26,080 --> 00:39:29,080 and it could be that during those exploration periods, 697 00:39:29,160 --> 00:39:32,160 when we didn't really understand the microcosmos, 698 00:39:32,240 --> 00:39:33,720 we have already sent bacteria, 699 00:39:33,800 --> 00:39:36,040 we've already sent viruses to those worlds, 700 00:39:36,120 --> 00:39:38,320 so we could've already infected them. 701 00:39:38,400 --> 00:39:40,120 We are absolutely sure 702 00:39:40,200 --> 00:39:43,600 that we have already delivered some aspects of our own microcosmos 703 00:39:43,680 --> 00:39:45,560 to different worlds out there. 704 00:39:45,640 --> 00:39:47,080 Every spacecraft we send, 705 00:39:47,160 --> 00:39:50,440 we cannot get rid of every tiny little bacterium, 706 00:39:50,520 --> 00:39:51,920 every tiny little virus. 707 00:39:52,000 --> 00:39:55,080 Bits of us already are on Mars. 708 00:39:57,480 --> 00:39:59,360 You're looking good. 709 00:39:59,440 --> 00:40:00,680 The Apollo 12 mission 710 00:40:00,760 --> 00:40:05,080 brought back bits of the lunar robotic probe, Surveyor 3, 711 00:40:05,160 --> 00:40:06,640 it found on the moon. 712 00:40:06,720 --> 00:40:11,160 Analysis of the probe found a bacterial contamination. 713 00:40:11,240 --> 00:40:13,400 We don't know where it came from. 714 00:40:13,480 --> 00:40:16,760 If that thing was infected before we sent it to the moon 715 00:40:16,840 --> 00:40:19,840 and it sat on the moon's surface for two years in a vacuum, 716 00:40:19,920 --> 00:40:22,560 changing temperatures, radiation from space, 717 00:40:22,640 --> 00:40:26,280 that really is telling us that we can infect other planets, 718 00:40:26,360 --> 00:40:29,320 and we should take this very seriously. 719 00:40:29,400 --> 00:40:32,320 We're ramping up our space missions. 720 00:40:32,400 --> 00:40:34,280 We're sending probe after probe 721 00:40:34,360 --> 00:40:37,560 to planets all throughout the solar system. 722 00:40:37,640 --> 00:40:42,040 Taking care to not send our own diseases 723 00:40:42,120 --> 00:40:45,440 out onto other planets is something we actually have to care about. 724 00:40:46,480 --> 00:40:47,560 NASA does care. 725 00:40:47,640 --> 00:40:49,440 Before launching a new probe, 726 00:40:49,520 --> 00:40:53,680 a planetary protection team deep cleans every inch. 727 00:40:54,720 --> 00:40:57,440 You try to bake the space craft, you try to disinfect things. 728 00:40:57,520 --> 00:41:00,160 You build everything and keep everything 729 00:41:00,240 --> 00:41:01,240 within a clean room, 730 00:41:01,320 --> 00:41:05,880 which has a pressure that blows dust out. 731 00:41:05,960 --> 00:41:08,040 Everybody wears what are called bunny suits, 732 00:41:08,120 --> 00:41:10,240 so nobody touches anything directly. 733 00:41:10,320 --> 00:41:11,960 But then, that's still not enough, 734 00:41:12,040 --> 00:41:14,000 because microbes are incredibly hardy. 735 00:41:15,240 --> 00:41:18,640 It's even more difficult to kill microcosmic stowaways 736 00:41:18,720 --> 00:41:20,960 if they're travelling inside an astronaut. 737 00:41:22,000 --> 00:41:24,400 In the not-too-distant future, 738 00:41:24,480 --> 00:41:26,960 we'll start sending not robot explorers, 739 00:41:27,040 --> 00:41:30,240 not probes to Mars, but people. 740 00:41:30,320 --> 00:41:35,680 An inherently dirty, mucky organism like myself. 741 00:41:35,760 --> 00:41:39,920 You can't sterilise a human. You can't remove all bacteria. 742 00:41:40,000 --> 00:41:41,240 We have to realise that 743 00:41:41,320 --> 00:41:43,480 we are bringing the microcosmos with us. 744 00:41:43,560 --> 00:41:47,240 And we may change worlds entirely without even noticing it. 745 00:41:49,160 --> 00:41:53,400 Planetary protection continues once the mission has landed. 746 00:41:53,480 --> 00:41:55,800 So, thinking about planetary protection 747 00:41:55,880 --> 00:41:59,200 means we really have to think about our actions in a whole new way. 748 00:41:59,280 --> 00:42:02,760 For example, if the rover were to find a pool of water, 749 00:42:02,840 --> 00:42:04,480 we really couldn't get that close, 750 00:42:04,560 --> 00:42:07,520 because we could not guarantee that even after all of this time, 751 00:42:07,600 --> 00:42:09,320 there wasn't some kind of microbe 752 00:42:09,400 --> 00:42:11,720 that could jump ship into that pool of water 753 00:42:11,800 --> 00:42:15,360 and then live happily on Mars and reproduce. 754 00:42:18,000 --> 00:42:21,160 Potentially our impact could be absolutely devastating 755 00:42:21,240 --> 00:42:23,880 on worlds that either have life or emerging life. 756 00:42:23,960 --> 00:42:27,120 And so we just need to take that responsibility seriously 757 00:42:27,200 --> 00:42:30,040 and be careful with the way in which we explore them. 758 00:42:31,080 --> 00:42:34,320 Humans bear a responsibility for the safety of the cosmos. 759 00:42:34,400 --> 00:42:37,200 Our track record on Earth isn't good. 760 00:42:38,760 --> 00:42:42,000 When we look at the pattern of exploration or colonisation 761 00:42:42,080 --> 00:42:45,440 that we use as humans, we are really invasive. 762 00:42:45,520 --> 00:42:47,520 We see a lot of destruction in our path. 763 00:42:47,600 --> 00:42:50,480 And we have to wonder if that's what we're going to do 764 00:42:50,560 --> 00:42:54,720 when we start to really explore and colonise outside of Earth. 765 00:42:54,800 --> 00:42:57,200 Like viruses, we also insist on spreading. 766 00:42:57,280 --> 00:42:59,360 We insist on spreading around our world, 767 00:42:59,440 --> 00:43:00,880 around our solar system. 768 00:43:00,960 --> 00:43:04,800 There is a great chance that we will cause utter destruction 769 00:43:04,880 --> 00:43:05,960 wherever we go. 770 00:43:07,000 --> 00:43:11,160 Our relationship with the microcosmos is complicated. 771 00:43:11,240 --> 00:43:16,480 It's killed millions of people, but without it, we wouldn't be here. 772 00:43:17,640 --> 00:43:19,040 This time we're living in 773 00:43:19,120 --> 00:43:21,600 is really causing us to reflect on the microcosmos. 774 00:43:21,680 --> 00:43:24,040 And the better we understand these micro organisms, 775 00:43:24,120 --> 00:43:27,440 the better able we are to deal with what's happening today. 776 00:43:27,520 --> 00:43:29,840 The coronavirus crisis reminds us 777 00:43:29,920 --> 00:43:32,640 we need to respect the world we cannot see, 778 00:43:32,720 --> 00:43:37,440 and recognise that the microcosmos is every bit as important to us 779 00:43:37,520 --> 00:43:38,920 as the greater universe. 780 00:43:40,040 --> 00:43:42,440 It's so easy, especially right now in history, 781 00:43:42,520 --> 00:43:43,600 to hear the word "virus" 782 00:43:43,680 --> 00:43:46,400 and think about how harmful they are, how dangerous they are. 783 00:43:46,480 --> 00:43:48,560 But remember that you are actually a creature 784 00:43:48,640 --> 00:43:49,880 built of viruses yourself. 785 00:43:49,960 --> 00:43:51,360 As far as we know, 786 00:43:51,440 --> 00:43:53,520 we've never been without the microcosmos. 787 00:43:53,600 --> 00:43:57,200 Microbes were here before us, they'll probably be here after us, 788 00:43:57,280 --> 00:43:58,800 and we need them to live. 789 00:44:00,640 --> 00:44:03,720 The microcosmos, it's absolutely essential. 790 00:44:03,800 --> 00:44:05,960 We couldn't function, we wouldn't survive, 791 00:44:06,040 --> 00:44:08,200 we wouldn't be here without it. 792 00:44:08,280 --> 00:44:13,520 But it's also our greatest ally and it's also our greatest enemy. 793 00:44:13,600 --> 00:44:15,600 subtitles by Deluxe 65969

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