Original subtitles

Previously on Pure Genius.

My mom hasn't been feeling well lately.

If you're really concerned about your mom, why don't you

just have a real and honest conversation with her?

Yeah, we don't do that.

Angie, your mom has cervical cancer.

Unfortunately, it's spread to her other organs

through her bloodstream.

I wish you'd mentioned that the Grim Reaper

was coming here to ruin our GSS trial.

I need more data from the animal models

for approval of a human trial.

The study wasn't approved.

I will not give up fighting for you.

I'm fighting for me.

(voice breaking): I might be running out of time, James.

Do you regret the decision you made back in Ohio?

Giving the boy with leukemia

the unapproved drug?

What the FDA doesn't know

can't hurt them.

Can't hurt me.

Oh, my God.

It worked.

(echoing): ♪ Fake records ♪

♪ Uh, uh ♪

♪ Uh, one two, one two ♪

♪ It's bigger than hip-hop ♪

♪ Hip-hop, hip-hop, hip ♪

♪ It's bigger than... One thing 'bout music ♪

♪ When it hit, you feel no pain ♪

♪ White folks say it controls your brain ♪

♪ I know better than that, that's game ♪

♪ And we ready for that, two soldiers head of the pack ♪

♪ Matter of fact who got the... ♪ ♪ What? ♪

♪ And where my army at? Rather attack than not react ♪

♪ Back the beats, it don't reflect ♪

♪ On how many records get sold... ♪

Whoa. Whoa!

♪ Whether your project's put on hold in the real world ♪

♪ It's bigger than all these fake records ♪

♪ Just do what you got to do, if that don't work... ♪

(grunts)

♪ We keep it crunk up. ♪

(boy screams)

(computer alarm beeping)

What's going on?

Fremont Jones, a new patient.

His oxygen level is low and his body temperature's dropping.

What's he being monitored for?

- A clotting disorder. - BROCKETT: Look at his body temp.

That's not a clotting issue.

And his oxygen sats are plummeting.

Wait, where is he?

On the Bay Bridge.

He's not on it.

He's under it. He's in the water.

Call the Coast Guard. Now.

W.

I didn't know if you were, um...

What was happening just then?

I was thinking.

Deeply.

James, I just, I want to let you know that over the next few days

I might be out of the hospital a bit.

Of course. Nothing wrong I hope.

No, no.

Just Julianna's coming today.

I wanted to ask her to move out here

once Luke leaves for college in the fall.

It's just something I...

- Your wife is here today? - Yeah, is that a problem?

No, not a problem, nothing we can't manage.

It will make what I need to tell you more complicated.

What is it?

I wasn't even sure if I was gonna tell you this,

but I just meditated on it, decided that you need to know

and not telling you will only make matters worse, so...

What is it?

Look.

♪ ♪

Cyanotic and hypothermic on scene.

Estimated submersion time: six minutes.

Multiple extremity fractures

with an open tib-fib on the right.

And pressure's 60 over palp.

Bilateral breath sounds,

no pneumothorax, so he's hemorrhaging somewhere.

Yeah, but nothing external.

Then get him into a bay; it's probably internal.

Two liters NS bolus, then O-neg,

and I need a FAST ultrasound to look for a hemoperitoneum.

(monitors beeping)

He's losing blood volume faster than we can replace it.

- BROCKETT: Oh, my God. - FAST positive.

Blood in Morison's pouch and left pericolic gutter.

- Ruptured spleen. - Lacerated liver.

BROCKETT: He has a massive intra-abdominal hemorrhage.

He needs surgery now.

Yeah, but he's gonna bleed out before we get there.

The DARPA foam.

(quietly): Yeah.

All right, prep, clean the field.

NURSE: Yes, doctor.

(alarm beeping, urgent chatter)

NURSE: Field prepped.

On three.

One, two...

(alarm continues beeping)

The foam should expand to keep him from bleeding out.

(monitor beeping)

- It's working. - Yeah, for now.

But all we did was buy ourselves a little time.

Can't fix anything until we remove the foam,

and when we do...

Bleed out all over again.

I still don't understand why I need to check in.

Because we're running tests and you'll feel more comfortable

having your own room.

It's like a fish bowl.

Which is why we have this. Look, you can make this room

any setting that makes you comfortable.

Like this.

Okay, okay, that was just an idea.

How about this?

Now I just feel cold.

Really, Mom?

Why can't we have a normal hospital room?

With blue walls a-and curtains?

And that smell.

That awful smell?

It makes it feel like a real hospital.

It doesn't matter what's on the walls,

the important thing is you're here, so we can get you...

better.

You know, Mrs. Lee had cancer.

She went to UCSF, they cured her.

They are affiliated with the university.

Everyone here is the best in their field.

Your grandmother had cancer.

She drank this tea...

Mom, tea did not get rid of grandma's cancer,

and it won't fix you.

Look, UCSF, they're gonna give you a 50/50 shot.

My people, we're gonna make this go away, period. Gone.

So just pick a setting for the wall,

and let me do my job, okay?

(whispers): Come on.

(sighs)

WALLACE: You gave Louis the treatment

that's banned from human trials.

BELL: I acknowledge I made that executive decision.

That was not your decision to make.

(whispers): You saw him.

Couldn't speak or move, now he's walking,

he's talking, clearly he's thinking.

- Clearly. - (phone beeping)

Ah, great, my wife's arriving.

Okay, I think we need to keep her off-campus for the moment.

Oh, you think?

Look, W, I'm sorry, but you saw him.

He was, he was dying. I had to do something.

You realize what this could mean.

I realize what it means to you, yes,

but I don't think you realize what you did.

The FDA prohibited use of that drug in human subjects,

and it's only been a few days,

- so we don't know the side effects. - W...

And my wife was the one who explicitly...

- (chuckles) Julianna. - Julianna!

- Hi. - Wonderful surprise.

- Hi, honey. - Nice to see you.

- Hi, thank you so much for... - Hi.

...dropping everything and coming out here.

Well, it sounds like big things are happening.

Yeah, listen, you're really exhausted from that flight.

No, I'm not.

Yeah, and we have a really crazy day today.

- Our, um... - Angie.

Angie Cheng.

Oh, yeah, the tech guru?

Yeah, her mom just got a... terrible diagnosis.

Cancer.

Oh. Wow, I'm sorry.

So you can imagine it's just...

Right, okay.

So, well, we shouldn't have lunch, then, after all.

If that's okay.

Yeah, it's... of course, it's fine.

I, uh, I brought a lot of work.

I'll just, you know, I'll find a place

- to stay and... hang out. - Great.

- Or... - Yeah.

Or, um, you could work at our place

'cause we're gonna work really late tonight. - Yeah.

- Really late. - That's okay. I can wait.

The cab just left, so...

No problem, you know, to get you a car home.

Yeah.

Okay. Fine.

I, uh, I can work from your place.

- Yeah, good choice. - Great.

Yeah.

The patient fell off the Bay Bridge this morning.

- Jumper? - Painter.

Fremont Jones, known as "Free."

Ah, the graffiti artist, huh?

I know his work; he's brilliant.

Well, right now he doesn't have much hope.

We used the DARPA foam to stop his internal bleeding,

but when we remove it for surgery, he'll bleed out.

VERLAINE: And there's another problem:

the water from the bay lowered his body temperature.

We tried to warm him up, but his toxic

metabolite production went through the roof.

So we need to keep his body temperature down

or those toxins will destroy his healthy tissues.

- What do we do? - I don't know.

But whatever we do, we can't wait.

He doesn't have long.

Oh, my God, Fremont?

You family?

Henry Jones, his brother.

Is-is he gonna be okay?

No, no, no.

You have to save him; he's all I have.

Mrs. Cheng has metastatic cervical cancer.

Unfortunately, it has spread to her uterus,

her bladder, her bowel and the pelvic lymph nodes.

No. No looks of pity,

no "I'm sorry about your mother's diagnosis,"

just... tell me how we fix this.

BELL: What if we used

a linear accelerator to enhance radiation?

Well, the incremental gains

would be outweighed by the unknowns.

I wouldn't recommend that.

We could use the gold particles

we used in Georgia Ray to locate

the exact location of the cancer and combine it

with robotic surgery.

Sure, uh, find more of the cancer,

increase the accuracy

as it's removed.

Well, that's adding technology,

but it won't materially improve the odds.

So what's the answer?

The truth is, Angie, that traditional treatment,

chemotherapy and radiation, that's highly successful.

In my opinion, that's the best course of action

for your mother right now.

CHENG: Wait, y-you're telling me

that giving my mother

a-a 50/50 chance at surviving the next five years

is the best we can do?

Us?

Bunker Hill Hospital? What do your ads say, James?

"Changing the world, one patient at a time"?

What about my mom?

How about everyone gives this some more thought?

We can reconvene later.

WALLACE: Um, step forward.

Yeah, um, hold out your hands, please.

Okay. Now grab my hands.

(chuckles softly)

I used to donate my time at a homeless shelter.

And again.

They had these big ladles.

You'd dish out soup

and feel like you were, uh, giving back.

Then I stopped being able to even

lift the ladle.

But now... (chuckles)

look at me.

It does look excellent.

I would like to run a more comprehensive study.

A brain biopsy would give us a picture

of what's happening on the cellular level.

Whatever you need.

I am grateful beyond what you know.

James... all of you.

You've given me my life back.

Okay, Louis.

- So, how does he seem? - Not now.

Those books look awfully familiar.

You applying to med school?

Yeah. Yeah.

I have my MCATs this week.

Oh, good for you.

We need more young blood

in the profession.

We're gonna try to do everything we can for your brother, Henry.

- Thank you. - Come here.

Looked at his history; this isn't the first time

you've been to the E.R. with him, is it?

It's-it's not. Um...

He's had accidents before.

But that doesn't seem to stop him.

I mean, my brother takes his art very seriously.

(sighs) Honestly, it gets frustrating

being around someone

who thinks they can break all of the rules

because they believe they have a greater purpose.

Yeah, I know someone like that, too.

Tell me, is there any way out of this for him?

We're gonna try as hard as we can, Henry.

But I want to explain exactly what we want to do,

so that you understand the risks.

I want you to be okay with this.

Okay?

Yeah.

Free's body systems are in crisis,

so we want to lower his temperature

even further; so far, in fact,

that it'll shut his body down, preventing further damage.

While he's hooked up to the suspended animation machine,

we'll have the chance to replace his blood

with a blood substitute that'll carry oxygen to his tissues

while we work to save him.

At the end of this process, his heart will stop.

All brain activity will stop.

But the progression of the toxins in his body

will also stop.

So, essentially...

you-you want to kill my brother?

On purpose?

And then we're gonna bring him back.

(monitor beeping)

(ventilator pumping)

Release the solution.

(monitor flatlines)

All right, his heart's stopped.

Let's get him to surgery now.

- James? - Yeah.

I have an idea to treat Angie's mom.

Okay.

It's a little crazy,

but I think it's worth pursuing.

What if we use nanobots?

DNA nanobots?

The problem with most cancer drugs

is the stronger you make them to kill all the cancer...

The higher the risk they'll kill all the healthy cells,

as well. Exactly.

So what if we use the nanobots...

To deliver the cancer drugs

specifically to the cancer cells.

How would you get them to recognize...

There's a lab;

they've added a triggering mechanism to nanobots.

It recognizes proteins unique to cancer cells.

So I was thinking maybe you could...

- I could write a program... - Yes.

...to teach them to deliver the drug payload

only when they come in contact with those proteins.

That way, it would allow us to use the strongest...

The strongest drugs available,

while mitigating the health risks.

Can we really do this?

You promised your mom a Bunker Hill miracle, Ang.

It's what we're gonna give her.

WALLACE: Let's start the clock on the cold ischemia.

Even in his hibernation state,

I'd expect permanent tissue death

at around four hour mark.

I agree, that's as far as we can push this.

We'll have to move fast.

Okay, Dr. Channarayapatra's team

will be handling the splenectomy.

Dr. Verlaine's team

will fixate the leg fracture, and our team will coordinate

- the liver repair. - Okay, ten blade.

Electrocautery knife.

- Orthopedic drill. - Ortho drill.

WALLACE: This man's life is in our hands.

Good luck, everyone.

(drill whirring)

STRAUSS: Traditionally, cervical cancer such as yours

would be treated with chemotherapy,

followed by radiation to try and eradicate

the cancer in your body.

But we're not gonna do that.

Well, that is an option.

And that treatment would be followed by surgery

to remove any remaining tissue.

- But we're not gonna do that, either. - Angie.

Sorry. Continue, Doctor.

Okay. What, uh, Angie is referring to

is that there is another option.

An awesome option. It uses nanobots.

Nanobots? This is one of your computer things?

No, no. No computers. Uh, let me explain.

Uh, actually, Scott, I-I made a presentation.

If it would help.

Sure.

Okay, so,

each nanobot is a stand of DNA

folded up like a clamshell.

Like origami.

Inside the clamshell, we put really strong medicine.

Way better than chemo.

Uh, and we can use it because we can program the nanobots

to attach only to the cancer cells.

It-it shouldn't hurt the healthy cells.

I mean, you shouldn't even get sick.

It's like Pac-Man.

It eats the cancer.

And you walk away.

Good as new.

Well, it's not quite that simple, Angie.

Believe me, my mom does not need

- to get into the weeds of this stuff. - Is this real?

It's brand-new.

So, we have no data.

So... it has never been done?

Look, you'll be the first, Mom.

Look, you're a special patient here.

We created this just for you.

(speaking Mandarin)

(sighs) Don't do that, Mom.

(speaking Mandarin)

(speaking Mandarin)

Nanobots?

(speaking Mandarin)

Mom, don't do that. Nanobots is the same in English

as it is in Mandarin. Tell her that

I'm trying to save her life.

(speaking Mandarin)

(speaking Mandarin)

(speaking Mandarin softly)

(speaking Mandarin)

What did she say?

Tell her. Tell me what?

Your mother would like to thank you

and me for everything that we've done,

but she wants to go to UCSF.

The surgery's finished.

But now you have to bring him back to life.

WALLACE: We're recirculating his blood.

As his body temperature rises,

we believe his heart will resume normal function.

There's one thing you'll learn about human anatomy:

there is a biological will to survive.

Don't underestimate that.

My brother is always hanging from some building

or a bridge,

or in a tunnel.

He almost got ran over by a BART train six months ago.

I just wish he could be normal.

(monitor beeping)

(rapid beeping)

(monitor beeping steadily)

Oh, my God, it worked.

You just saved his life.

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