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- Crowds have gathered
today to hear the verdict

of the Swedish
police investigation

into celebrity surgeon
Paolo Macchiarini,

who has been accused
of medical misconduct.

Officials are hoping
for an indictment

to be issued today in the case

that has taken the global
medical community by storm.

- Do you trust me?

- Oh!
- Oh, my goodness!

- Hello, Keziah.

- The recellularization
is complete, Doctor.

- Wonderful.

Now I need you to
count back from 100.

Knife.

- ♪ She was the one,
she was the one ♪

♪ She was the one.
She was the one ♪

- ♪ She was the one,
she was the one ♪

- I'm not here to
talk about politics.

- Benita?
- Yeah?

- Have you seen our girl?

- Shoot! Mm.

- Happy birthday!
- Happy birthday!

Oh. You're ringing.

- Oh.

Hello?

- Always making
such a racket, B.

- Says the guy dragging me
to the hospital at 1:00 a.m.

What happened?

- Ask him.

- Hi.

Is he okay?
- Yes.

Uh, is this your
wife? Both: Ex.

- Okay, well, John was admitted

after he was found
unconscious in his apartment.

I've left word for
your oncologist,

but this is likely caused
by the brain tumor.

- So does that mean the
treatment is not working?

- It doesn't mean
anything for sure.

But your doctor has
discussed your prognosis?

- Yeah, we know. My
chances are slim.

- 6%. 6%.

That's the number they love
to throw around all the time,

but someone's got
to be the 6%, right?

Right.

Well, I'll go check
your bloodwork.

Just, uh, sit tight.
- Yeah, I'll be right here.

- You look good, B.

- It was Kimmy's
birthday tonight.

- Well, I saved you
from a wicked hangover.

- Yeah.
- You're welcome.

So what do we tell Lizzi?

- We wait.

You just started this
round of treatment.

We don't have any
of the answers yet,

so I think we wait.
- Okay.

Okay. Yeah.

But, Benita...

I'm sick.

- Someone's got to
be the 6%, John.

- Morning, Benita.
- Morning, Larry.

This is for me, right?
- Yep.

- Thank you.

- Morning, Benita.
- Good morning.

Oh, I have pitches for you.
- Great.

- Lunch?
- Sure.

Meet you in the commissary?
- Yuck. See you then.

Oh, you have my fugitive story?
- Uh...

- Tomorrow. I mean it.

Ah, good morning to you.
- I did shots.

Yeah, you did.

- Sorry I had to take off.
- Oh, God, please.

You don't need...

I'm sorry.

How is he?
- The same.

We can skip the condolences.

- Sure, whatever you need.

Aw, that's pretty.

- Those are John's.

He asked me to look after
them while he's, you know...

Those are his favorite.

Work is good. Work
is good. Work is good.

- Copy that. Work is good.

- I've been trying
to get an angle

on this medical piece for
a TV special I'm producing.

- Generational medicine?

- Regenerative medicine.
- Sure.

- I read this piece
in "The Times"

about this little girl
who needs a new windpipe,

and her family's working
with this doctor in Europe

who's developing
artificial organs.

- Medical miracles?

- Ooh, I hate that
word... "miracle."

- I don't hate this guy.
- That's the doctor.

He's actually got a
pretty impressive CV.

He's worked all
around the world,

published in "The Lancet,"

research grants
out of Karolinska.

It's where they give
out the Nobel Prize.

- Hmm.
- And he's Italian.

- Mm. Roma or Olive Garden?

- I don't know.

- So...

who are we today?

Oh. Bina.

That's cute.
- So this little girl...

she lives in this
tiny town, Yongsan-gu.

- Korea?
- Yeah.

But she's coming to the States
for her surgery... that's her.

That's Hannah Warren.

- This is a really
good story, B.

- It is, right?
- Mm-hmm.

- I like it. It's...

it's really hopeful.

- Yeah, this is worth
missing lunch for.

- Fuck off. This
guy's brilliant.

Did you read the material?
- I'm getting there.

- It's really interesting.

- You having trouble there?
- A little bit.

- I think it's this one here.
- Ah, this one, yeah.

Okay.
- There you go.

All good?
- Yeah, all good, yeah.

- It works.
- Awesome. Thank you.

- Okay, great.

uh,
colleagues, good afternoon.

It's great to see

such a wide spectrum of
fields represented here today.

I only wish some
of my own lectures

could get crowds
like this.

Now, I'm sure you're
all eager to hear

from Karolinska's
newest addition.

He is a professor, researcher,
and thoracic surgeon...

Dr. Paolo Macchiarini.

- Thank you, Provost Hedley.

I'm simply happy that
you will have me here

working in this
incredible institution.

"God breathed into Adam
the breath of life,

and he became man"...

Genesis 2:7.

Breath is the essence of life,

the one thing that
comes naturally

to all of us from
birth... to breathe.

When a patient has
a damaged trachea,

our options, unfortunately,
have been very limited.

Tracheostomies allow
patients to live, yes,

but with what quality of life?

The focus of my research
is tracheal transplants

with the help of stem cells...

"the God cells" as they
have been called recently.

We harvest the donor
trachea from a cadaver

and strip it of the donor cells.

Then we reseed the organ with
the patient's stem cells,

preparing it for implantation.

I have successfully
applied this technique

to multiple patients
around the world...

most recently to a
19-year-old patient

named Keziah Shorten in London.

She was diagnosed with
adenoid cystic carcinoma

and only had months to live.

Now, two months
after the operation,

she's healthy and happy
with her donor trachea.

This is an exciting step,

but it is still a
very flawed process.

Why? Because of the donors.

We always have to wait for
the perfect-size trachea.

So I thought, what
if we skip that step?

And so we did.

We were able to eliminate
the donors altogether

by developing
biosynthetic tracheas...

custom-designed to fit
the individual patient.

Using the same process,
we seed the trachea

with the patient's stem cells,

transforming it
into a living organ.

We have conducted swine trials
with just incredible results.

Look at those happy
pigs.

And that brings us here today,

where I'm happy to announce

the final phase of our work...

the very first human
biosynthetic transplant

to take place right
here at Karolinska.

Once we conquer the trachea,

we'll be able to expand
our work to heart valves,

blood vessels,
even entire organs.

The potential for this
technology is endless.

Imagine for a moment
buying a 3D-printed organ

off the shelf,

like groceries
from a supermarket.

Imagine a world where no
human being will ever die

while waiting for
an organ donor.

Imagine this...

the future of medicine...

the future that we
will build together.

Thank you.

- Ah, Dr. Lasbrey,
let me introduce you.

- Dr. Macchiarini.
- Oh, please call me Paolo.

- Paolo, wonderful to meet you.
- Thank you.

- I've been following
your research closely,

since your first bronchus
transplants in Barcelona.

- Oh, thank you.
That's very flattering.

- Uh, Dr. Lasbrey's a
cardiothoracic surgeon.

Uh, she's been working

on some stem-cell-regeneration
research of her own.

- Oh.

- My focus is vascular repair...
blood vessel regeneration.

I've had some progress,
but I never thought

to recellularize a
bioartificial graft.

Do you build the scaffolds
to replicate the porousness

of real tracheal cartilage?
- Exactly.

- So you're basically
tricking the body

into thinking the implant's
already a part of you.

Well, I
haven't really thought

about it that way, but, yes,
that's exactly it, yeah.

- It's brilliant.
- Oh.

- The broad applications
for technology like this...

- How? H-h-how do
you trick them?

More specifically,

h-how does a synthetic
cell create blood vessels,

uh, basal layers, and
fend off bacteria?

- And this is Dr. Gamelli,

also one of our
cardiothoracic surgeons.

He'll be in charge of
post-operative care

for any patients you
bring to Karolinska.

- What's up?
- Very nice to meet you.

Dr. Gamelli, I could walk you
through the research again,

if you like.

- That's very thoughtful of you.

- Yes, well, we are hopeful
that Dr. Macchiarini's research

will establish Karolinska

as the world leader in
regenerative medicine.

Perhaps he'll even
bring the Nobel home.

- Oh, well, we're just at
the beginning of our work.

- But the implications
for future transplants

are historic.

- Dr. Lasbrey, would you...
would you be interested

in assisting on the
first transplant patient?

- "Interested" isn't
exactly how I'd put it.

- Then it's done.

- Oh, thank you,
really. I-I'm honored.

Welcome to the team.

- I do wonder, as it
relates to my research,

how are the grafts
transformed into living cells?

How do they come alive?

It's, uh...

it's like magic.

- Benita.

- You were supposed to be
here at 3:00, Dr. Macchiarini.

- I'm so sorry. I was riding,
and I went over a bridge

that was supposed to
take me to Brooklyn,

when, in fact, I was
already in Brooklyn.

So that bridge took
me to Staten Island,

which was very interesting
but very far away.

So I'm deeply, deeply
sorry to keep you waiting.

- I guess picturing
you on that bike

crossing the Verrazzano Bridge
might be punishment enough.

Verrazzano
Bridge is the name?

- Can I get you something, sir?
- Um, an espresso with sugar.

- Regular sugar or, um...

Uh, sorry.

Ah, oui.

Okay.

I mean, sugar is sugar, as
long as it's sweet, okay?

Merci beaucoup.

- How many languages do
you speak, Dr. Macchiarini?

- Um, one I speak
okay, six very poorly.

- Which one is okay?
- No one will tell me.

Do you bring that
everywhere you go?

- That is rented...
guilty pleasure.

- Why guilty?

- Do you ride?

- Uh, I did, a long time ago.

- Well, maybe you
will ride again.

- As I said on the phone,

I'm producing a special
on regenerative medicine,

and I'm very interested

in your upcoming operation
on Hannah Warren.

Is this okay?
- Yeah.

- Tell me about it.

- She was born with
a congenital anomaly

called tracheal agenesis.

Very rare.
- Mm.

- Her windpipe never
fully developed,

so she's never been able
to breathe on her own.

She's never been able to
even leave the hospital.

It's a tragedy.

She's stuck in a bed,
not being able to...

to go outside, to play,

to... to run, to
eat lollipops...

to be a kid.

Do you have children?

- I have a 9-year-old daughter.

- Can you imagine

if your daughter never
tasted a lollipop?

- No. No, I can't.
- Yeah, that's... that's Hannah.

Do you mind if we...

Should we take a walk outside?

- Sure.
- Yeah.

I think it's better, yeah.
- Okay.

So this is the first artificial
trachea transplant in the U.S.,

and you chose Chicago because
of Hannah's pediatrician?

- Yes. He works at
a Catholic hospital,

and they're funding
the operation.

- The Catholic Church
doesn't mind supporting

stem cell research?

- Well, actually there is,
uh... there is a high commission

at the Vatican involved
in stem cell research.

- Really?
- Yeah.

It's not only that.

They really want to help Hannah.

They... they believe she's
been sent to us by God.

- Sent to you for a miracle?

Is that what you want to be
known for... performing miracles?

Well...

That sounds a little...
a little too...

What's the word you
use here? Um, h-hokey?

- Hokey, yeah.
- Hokey, yeah, sounds...

- Just a little hokey,
Dr. Macchiarini.

- Too much.
- So, even though

you've performed this
operation before,

Hannah will be the
youngest patient of yours

to ever receive a
biosynthetic transplant.

- That's correct.

- Does that give you pause?

- I've been thinking lately
that my entire career,

maybe even my entire life

has led me here...

to this little girl,

who definitely needs
this more than anyone.

- It's still an extremely
experimental procedure.

- Yeah, it is. It's
new. It's complicated.

It's a little controversial.

We have to fight really
hard to get permission

to operate here in the U.S.

But without it, Hannah
will certainly die.

So, if there's one chance
to save one person,

I think it's worth the risk.

- So I'm doing a story,

and I want Hannah's journey
to be the focus of the piece.

Actually, I was hoping that
you might be able to put me

in touch with the
Warrens directly.

- Okay, I'll see what I can do.
- Great.

All right, Doctor, it's
officially after work hours.

I have to go pick
up my daughter.

- What's her name?
- Her name is Lizzi.

- Lizzi.
- Mm.

- Well, I hope I get to hear

more about her
next time we meet.

- I hope you're on
time next time we meet.

Okay.

- Huh.

Okay, driving car,
honking, beep, beep.

- Cars, uh, traffic?
Traffic! Traffic.

Okay, traffic.
- Okay, okay.

- Wait, where'd we go?

- Butter bread? Toast?

- Peanut butter?

- Traffic... traffic
peanut butter!

- Okay, time's up.

Traffic jam! All: Oh!

- Traffic jam!

I love traffic peanut
butter, though.

But she was like, yes.

- All right, it's
bedtime for one of us.

- Mom.

- No, I gave you an
extra half hour, kiddo.

Come here.

Mom, I can't breathe.

- I know, but I'm
gonna be at the airport

when you wake up in the morning,

and Laura's gonna
take you to school.

- Why can't Daddy just take me?

- 'Cause he's still
not feeling well.

But we're gonna go visit
him as soon as I get back.

I promise you, okay?

All right, brush, jammies,
wash, bed, please.

I'll be right in.

- Night.

- I'm a monster.
- Stop it.

How long are you
gonna be in Chicago?

- Too long.

You would think that
leaving would get easier,

but it does not.

- Well, maybe you can distract
yourself by playing doctor.

Oh, stop it.

Is he single?
- Divorced.

- Ah, see? Look at you
checking his stats.

- Don't be ridiculous.
He's a source.

- Not even a sexy,
charming doctor source

is worth getting fired over.

- Uh, if I can handle myself
around sexy, charming Obama,

I can handle myself around
sexy, charming doctor.

- I know, I know.
I'm just kidding.

Both: You don't
fuck your sources.

- Thank you.
- Well, he's not my source.

So, if you need an
Italian translator,

just put in a good word for me.

- Oh.
- If it comes up naturally.

- If it comes up naturally.
- I'm just saying.

Yeah.

- Hey, that doesn't sound
like brushing to me.

- Okay, okay.

- How's John?

- You know.

- Getting worse?

- I don't know what
I'm gonna do, Kim.

- You're a great
mother, B. Just...

follow your instincts.

- I don't think I have instincts

when it comes to
something like this.

Svensson... scientist.

Macchiarini... genius.

Well, that is an interesting
way to say hello.

Hi, I'm Paolo.

Not so much a genius.

- Anders Svensson,
not so much scientist.

He's a little shit.

Oh, I'm delighted to meet
you, Dr. Macchiarini.

- Thank you.

- The whole building is... zzz...
buzzing about your arrival.

I'm sorry to have
missed your lecture.

I've been busy with my
friends here, I'm afraid...

a heart study.
- Yeah, yeah, not at all.

I'm actually very
glad to meet you.

I read your research on
progenitor cell functions

in skin regeneration...

very interesting.
- Thank you.

- So these are your friends.
- Yes.

- Eric, Gunnar.

So you give them names.
- Ah, busted!

Well, I...

I know maybe I shouldn't,

but sitting in
these labs all day,

it all quickly become numbers,
gene strains in your head.

It's easy to forget we deal
with real life and death.

So I name the rats.

So here's Mikael 7.
He's a bit of a rascal.

Lost his appetite.

- So, Doctor, um, I'm very sorry

to come to you right away
with a favor, but here I am.

- No, uh, please.

- I was wondering if
you would be interested

in collaborating on rat
trials to test our tracheas.

Wow. I...

Ooh, I'd be honored. I...

But if I've heard correctly,

you've already
completed swine trials.

- Yeah, and they went very well,

but, you know, the more
trials, the better.

- I couldn't agree more.

Ah, methodology is a lost art.

- So you will be interested
in conducting the trials?

Ooh-cha-cha!

- Absolutely. I'd be honored.

- Yeah, fantastic.
Welcome to the team.

- Ah.

- Hey.

- Hi.

My key card's not working.
- Mine neither.

- Well, the woman said
she'd be right back.

I don't know... I thought I'd
try to get a little work done

in the meantime.

- Gambling?
- What?

- Are you a gambler?
- Oh, no. No.

These are... these are
conversation cards.

- What is that?

- They're kind of like
conversation starters.

- May I?
- Yeah, yeah.

I... I found them
when I was young.

They were my
grandmother's, I think.

My family's a little...

But, uh, they're kind of my
secret weapon for interviews.

Mm, they are? Both: Mm-hmm.

Yeah, people get nervous when
they have to answer questions.

- Ah, of course.

- And this kind of makes
it like a little game.

I just say, pick a card.

- I don't know.
I think it works.

- Ah, I'm sure they do.

Your subjects are so relaxed,

it's like they're
not even on camera.

- Thank you.
- Yeah.

- You are very good
on camera, you know.

- No, no, not at first.

I could use your cards.

- Actually, I-I did.

I did use one of
them on you already.

- You did?
- Mm-hmm.

Mm, yeah.

"If you could be famous for
one thing, what would it be"?

- And you never
answered the question.

- And I'm never going to.
- Okay.

Well, then go ahead
and pick another card.

Go for it.

"Tell me a story about
your childhood fear."

Okay.

Well, life was difficult
when I was a boy.

My mom is Italian,

but I never really
felt Italian myself.

It was just the two of us.

We moved very often.

Spain, of course, but before
that, it was Switzerland.

And that was lonely.

That feeling, that
was my fear...

being an immigrant,
underestimated, isolated.

I held on to that feeling
for a very long time,

and... and I never wanted
to feel that way ever again.

- Miss, I'm so
sorry for the delay.

- Oh, thank you.
- You're welcome.

- Uh, miss, sorry, could
you help me, too, please?

- Oh, yes, of course.
- Thank you.

- I thought you were gonna
say spiders or something.

- Mm.

- Yeah, here's the pink one.

Or should we do that?

She was, um... she was
blue when she came out.

And, uh, we, uh... we
just... we begged her.

We said, cry, baby girl, cry.

And, um, they were able to
find a, uh... a tiny hole

leading to her lungs there,

but they said she would never
leave the hospital, you know,

that she wouldn't survive.

So I, um... I did a, uh, uh...

I did... I did a Google search
on... on trachea surgeries,

and I just started
seeing more and more

about Dr. Macchiarini's
groundbreaking transplants...

you know, the Miracle Man.

So she just needs
one thing, right?

Yeah.

And that's a
windpipe right there.

And then everything's
going to be fine, okay?

- We will monitor her
for a few more days

while we prepare the trachea.

We have discussed the details...

at length, the risks.

It is a very difficult surgery.

- We have tried everything.

You were the only one willing.

You were the only
one who gave us hope.

You are the one who will
give her a chance to live.

Yeah.

I will try my best.

- Believe me.
- Okay.

- Hmm.
- Yeah, thanks.

- Hmm?

Hello, Hannah.

Right? Hmm, Hannah?

Hmm?

I have sort of a
tradition when I travel.

I like to eat paella.

It's kind of like
a good-luck thing.

It reminds me of home.

Anyway, there's a restaurant,
a good one, close by.

Maybe you want to join me?

- Yeah.

- Yeah?
- That... that sounds great.

Hey, guys?
- Hmm?

- You want to join the
doc for dinner tonight?

- Sure, sounds good.
- Let's do it.

- Okay, yeah, just
text me the address.

- Okay.
- Yeah.

All right, let's go.

- You didn't eat tonight.

- You were watching me eat?

- No, I was watching
you not eat.

- Is there anything I can do

about what is making you so sad?

- How do you know I'm so sad?

- Anyone who's really
looking could see.

- It's my ex-husband, John.

It started with the headaches

and then the fainting
and forgetting, and...

and then they started throwing
around the word "terminal."

- Glioblastoma?
- Yeah.

- Is it operable?

- No, the... the tumor is
too deeply embedded in the...

No, it's not.

- I'm sorry.

- And, you know,
with our daughter...

- Lizzi.
- Lizzi, yeah.

You know, even though
we're not together,

it's always been
the three of us.

- Mm, I understand.

I have two children.

They're grown now, but when
their mother and I divorced,

it was difficult.

But, you know, children are
much stronger than we think.

Look at Hannah.

- I just keep
second-guessing myself...

what to tell her, if
I should tell her.

And then I get pissed

because I don't want to have
to tell her anything, you know?

And then I think,
maybe I shouldn't,

because I've been doing
all of this research.

And, you know, 6%...

that's what they
keep telling us, 6%.

Someone's got to
be the 6%, right?

- Benita...

I have seen far
too much death...

sudden, expected, certain.

You know your daughter,
so you know what's best.

But to be able to say goodbye...

that is a gift.

- Hi.
- Hey, welcome back.

She's in her room.

Mom,
you're home early!

- Yeah. Just for the day.
I have to go back tomorrow.

- Oh, my God, so I
have to tell you this,

'cause I was going to
tell you this last night

whenever we talked.

But I wanted to see
what happened today

so I can tell you
the whole story.

I can't wait
to hear all about it.

But first, I wanted to
talk to you about your dad.

- Okay.

- Okay.

It's that first door up here.

Knock, knock.

- Hi, sweetheart.

- Vasilyev to Orlov,
to Orlov again.

- You losing?
- Hey, there you are.

No, no, no, we're ahead.

Those Russian bastards,
they can't stop Zlatan.

- Skol.
- Cheers.

- Happy Hump Day happy hour!
- You're embarrassing.

Mm.

Marja?

You want me to ask
her out for you?

- No, don't...
- Hey, hey, hey.

It would be nice

for Wilma and I to have
couples for dinner.

- Well, I'm washing my
hair that night, so...

Oh.

- I heard you joined
Macchiarini's research team.

- Yes, new rat trials.

Uh, he, uh... uh...
- What?

- Well, I thought
the point of our...

Hump
Day happy hour...

Is that you
don't have to talk about work.

- I'm a complicated man, Anders.

Sorry. Apologize for
that, my language.

- Macchiarini.

- Yeah, his work
is exciting, no?

- Meh.

- "Meh"?

Your lack of interest is
decidedly uninteresting.

You think everyone is "meh."

- The science
doesn't seem sound.

- Well, you know,
it's not exactly

your kind of
science... no offense.

I said, no offense.

- I will admit I don't get it.

I don't understand how
a-a plastic trachea

can produce its
own blood supply.

- Well, stem cells.
- That's just it.

Stem cell research,
regenerative medicine...

it's... it's like an arms race.

Everybody's scrambling
for the most patents,

the most grants, who
can make the most money.

That's not how medicine works.
It's not how it should work.

If I wanted that world, I could
have stayed in New Jersey.

That's a penalty
every day in the week.

Oh, sorry, you were... you...
you were talking to me?

- Mm.

- Hey, I agree with
you on the science.

But this is the way it works.

Competition fuels progress.

- Now a lovely play,
through across...

- I-I... Hey, oh, oh, hey!

All right.

I'm cool.

- I'm going... I'm going to
make it warm because it's cold.

See, it's cold.

Okay, Hannah, breathe.

Breathe in with me.

You want me to check her, too?

Yes?

Mm.

You want
me to take that out?

Hmm? Yeah?

Hmm?

We will tomorrow, yeah?

- Hi.

Uh, could I get
a glass of Malbec

to take up to my room, please?

Thanks.
- Sure.

- Hi.
- Hi.

- Is that Hannah's file?

- Yeah.

Just going through
the details again.

- You seem to have
a lot of rituals.

I didn't realize surgeons
were so superstitious.

- It's more like a prayer.

It doesn't matter how many times

I perform these operations,
I always get nervous.

You think you're prepared,

but there can always be
something that you miss

that can cost a life.

- I...

cannot imagine the stress.

Someone's life in your hands...

But I have watched
you for a while now,

and the people around
you, your patients...

you really give them hope.

They trust you.

Maybe you should trust you.

Good night, Doc.

- Knife.

- Hey.

- She's okay?

- The surgery went well.

Oh.

- There were no complications,

but she'll be asleep
for a while longer.

- What do we do now?

- Now we wait.

- Okay, Hannah, you're going
to give us a deep breath.

Another one.

So how
are you feeling, then, huh?

Good!

She's feeling good.

We have a little
present for you.

Look, look.

Ah, what's that?

Oh, wow.

- Go ahead, honey. Yeah.

Good.

It tastes good, yeah?
- Oh.

She loves it.

- It tastes good.

- Hey.
- Hi.

- Hi.

- Got some ice, huh?
- Uh-huh, yeah.

- Today was...

Unlike anything
I've ever seen.

I...

- So you're happy with
the ending of your story?

- It's hopeful, which is
what I was hoping for, yeah.

What you did...

It was a miracle.

- I wanted to say thank you...

For what you said to me the
night before the operation.

Those words...

they were more important
than you could possibly know.

Paolo, I shouldn't.

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