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These are the user uploaded subtitles that are being translated: 1 00:00:02,190 --> 00:00:05,690 Boy or girl? 2 00:00:05,690 --> 00:00:07,960 It's the eternal question. 3 00:00:10,330 --> 00:00:14,000 But that question may have more than two answers. 4 00:00:16,330 --> 00:00:18,100 Science is finding the line 5 00:00:18,100 --> 00:00:22,040 between male and female bodies is blurred, 6 00:00:22,040 --> 00:00:26,840 identifying the hallmarks of a transgender brain 7 00:00:26,840 --> 00:00:32,310 and studying people who seem to change sex spontaneously. 8 00:00:32,320 --> 00:00:35,080 Are some people neither male nor female? 9 00:00:37,620 --> 00:00:39,990 Are there more than two sexes? 10 00:00:45,630 --> 00:00:50,070 Space, time, life itself. 11 00:00:52,570 --> 00:00:56,910 The secrets of the cosmos lie through the wormhole. 12 00:00:56,910 --> 00:00:59,910 Captions by vitac... www.Vitac.Com 13 00:00:59,910 --> 00:01:02,910 captions paid for by Discovery communications 14 00:01:09,750 --> 00:01:13,350 Everyone who ever lived was created 15 00:01:13,360 --> 00:01:17,690 from the genes of one man and one woman. 16 00:01:17,690 --> 00:01:21,730 Those genes blended together to make a unique child... 17 00:01:21,730 --> 00:01:25,270 With dad's dark hair and mom's curls, 18 00:01:25,270 --> 00:01:30,910 or with mom's lips that curl into dad's smile. 19 00:01:30,910 --> 00:01:34,510 One thing, however, isn't a blend... 20 00:01:34,510 --> 00:01:37,450 The child's sex. 21 00:01:37,450 --> 00:01:41,350 It's either male or female. 22 00:01:41,350 --> 00:01:44,290 But is there something in between? 23 00:01:44,290 --> 00:01:47,360 Many transgender people, their friends and families 24 00:01:47,360 --> 00:01:50,390 say there is. 25 00:01:50,390 --> 00:01:53,630 But what does science say? 26 00:01:53,630 --> 00:01:55,700 Today, that question is playing out 27 00:01:55,700 --> 00:01:58,030 in a very public arena. 28 00:02:01,970 --> 00:02:04,040 For more then 100 years, 29 00:02:04,040 --> 00:02:07,040 athletes have pushed themselves to the limit 30 00:02:07,040 --> 00:02:11,250 to be the strongest, the fastest. 31 00:02:11,250 --> 00:02:13,820 And for almost as long, 32 00:02:13,820 --> 00:02:16,420 some have been doing whatever it takes to gain 33 00:02:16,420 --> 00:02:19,950 that winning edge. 34 00:02:19,960 --> 00:02:24,460 But endocrinologist Richard Holt is watching them. 35 00:02:24,460 --> 00:02:28,160 He's a pioneer of tests designed to spot athletes 36 00:02:28,170 --> 00:02:30,530 seeking an unfair advantage. 37 00:02:30,530 --> 00:02:32,670 The difference between somebody winning 38 00:02:32,670 --> 00:02:35,640 and somebody not winning is absolutely tiny. 39 00:02:35,640 --> 00:02:39,710 We're talking about maybe less than 1%. 40 00:02:39,710 --> 00:02:41,440 There are a number of athletes who might be 41 00:02:41,440 --> 00:02:44,410 just that little bit away, and they think, 42 00:02:44,410 --> 00:02:47,780 "well, maybe if I just take a little bit of extra 43 00:02:47,780 --> 00:02:51,450 then I'll be able to reach the pinnacle of the career." 44 00:02:51,450 --> 00:02:54,860 Richard's human growth hormone test debuted 45 00:02:54,860 --> 00:02:56,690 at the 2012 London Olympics, 46 00:02:56,690 --> 00:03:00,960 but lately he's entered a more controversial arena... 47 00:03:00,960 --> 00:03:04,630 Verifying athletes' sexes. 48 00:03:05,870 --> 00:03:09,540 Indian sprinter Dutee Chand grew up as a woman 49 00:03:09,540 --> 00:03:11,340 and runs against them. 50 00:03:13,380 --> 00:03:16,950 But on the eve of the 2014 Commonwealth games, 51 00:03:16,950 --> 00:03:19,180 she ran into a problem. 52 00:03:19,180 --> 00:03:21,380 She was found to have high levels 53 00:03:21,380 --> 00:03:24,490 of testosterone in her blood, 54 00:03:24,490 --> 00:03:26,990 and fell foul of the regulations. 55 00:03:26,990 --> 00:03:28,990 She was banned from competition. 56 00:03:28,990 --> 00:03:32,330 Men and women both make testosterone naturally 57 00:03:32,330 --> 00:03:34,800 but in very different quantities. 58 00:03:34,800 --> 00:03:37,400 According to international athletic rules, 59 00:03:37,400 --> 00:03:41,270 Chand fell outside the female reference range. 60 00:03:41,270 --> 00:03:45,840 She did not fit the definition of a woman. 61 00:03:45,840 --> 00:03:48,440 Imagine we had two athletes, a man and a woman, 62 00:03:48,450 --> 00:03:50,310 and we looked at the two together. 63 00:03:50,310 --> 00:03:51,510 We'd see that, on average, 64 00:03:51,510 --> 00:03:53,650 the man would be taller than the woman, 65 00:03:53,650 --> 00:03:56,550 he'd have broader shoulders than the woman, 66 00:03:56,550 --> 00:03:58,820 he'd have bigger hands than the woman. 67 00:03:58,820 --> 00:04:00,190 Men, on average, 68 00:04:00,190 --> 00:04:03,630 have much more lean body mass than women. 69 00:04:03,630 --> 00:04:05,460 If you've got more lean body mass, 70 00:04:05,460 --> 00:04:08,960 you've got a stronger engine. 71 00:04:08,970 --> 00:04:12,330 To avoid men sneaking into women's events, 72 00:04:12,340 --> 00:04:14,070 sporting federations began 73 00:04:14,070 --> 00:04:18,070 in the 1960s to certify women as women. 74 00:04:18,070 --> 00:04:21,340 They did this the old-fashioned way... 75 00:04:21,340 --> 00:04:24,380 By visual inspection. 76 00:04:24,380 --> 00:04:27,420 But this led to controversy. 77 00:04:27,420 --> 00:04:32,090 Athletes thought the practice was indecent and disrespectful. 78 00:04:34,420 --> 00:04:37,190 Since the 2000s, some women have, 79 00:04:37,190 --> 00:04:41,160 instead, been subjected to testosterone tests. 80 00:04:41,160 --> 00:04:43,160 But a recent large study 81 00:04:43,170 --> 00:04:45,600 of more than 800 elite athletes found 82 00:04:45,600 --> 00:04:50,270 that testosterone tests can't always tell men from women. 83 00:04:50,270 --> 00:04:53,210 What they found was that there are about 15% of men 84 00:04:53,210 --> 00:04:54,840 that had testosterone levels 85 00:04:54,840 --> 00:04:57,880 that were below the typical normal reference range 86 00:04:57,880 --> 00:05:00,980 and there are about 30% of women whose testosterone 87 00:05:00,980 --> 00:05:05,150 were above the upper limits of the female range. 88 00:05:05,160 --> 00:05:07,720 In other words, there's no clear dividing line 89 00:05:07,720 --> 00:05:11,360 between male and female testosterone levels. 90 00:05:11,360 --> 00:05:15,160 In fact, there's no evidence that naturally high testosterone 91 00:05:15,170 --> 00:05:17,770 even gives you a performance advantage. 92 00:05:17,770 --> 00:05:21,700 If testosterone was really key to athletic performance, 93 00:05:21,710 --> 00:05:24,940 what we would expect is that, among men, 94 00:05:24,940 --> 00:05:27,410 men with the highest level testosterone, 95 00:05:27,410 --> 00:05:29,540 those men were winning the races, 96 00:05:29,550 --> 00:05:30,880 but I can tell you, 97 00:05:30,880 --> 00:05:33,580 some of them had very, very low testosterone levels, 98 00:05:33,580 --> 00:05:36,080 and despite having very low testosterone levels, 99 00:05:36,090 --> 00:05:38,250 they were still capable of competing 100 00:05:38,250 --> 00:05:41,720 at the very, very highest level. 101 00:05:41,730 --> 00:05:45,060 Dutee Chand fought the ruling against her, 102 00:05:45,060 --> 00:05:47,430 claiming it was discriminatory to ban her 103 00:05:47,430 --> 00:05:50,930 for a naturally occurring condition. 104 00:05:50,930 --> 00:05:56,040 In 2015, she won back the right to compete. 105 00:05:56,040 --> 00:05:58,570 Testosterone screening for female athletes 106 00:05:58,580 --> 00:06:01,540 has been suspended for the moment, 107 00:06:01,540 --> 00:06:04,550 but there's no agreement on what should replace it. 108 00:06:04,550 --> 00:06:07,380 I think the best way of actually determining 109 00:06:07,380 --> 00:06:09,780 whether a woman should be able to compete 110 00:06:09,790 --> 00:06:12,620 as a woman is the way that she self-identifies. 111 00:06:12,620 --> 00:06:15,060 If she's always seen herself as a woman, 112 00:06:15,060 --> 00:06:17,590 regardless of what her testosterone levels are, 113 00:06:17,590 --> 00:06:20,600 I think she should be allowed to compete as a woman. 114 00:06:20,600 --> 00:06:22,860 Sporting federations are still wrestling 115 00:06:22,870 --> 00:06:26,700 with how to draw the line between male and female bodies. 116 00:06:29,810 --> 00:06:33,340 But Israeli neuroscientist Daphna Joel has been looking 117 00:06:33,340 --> 00:06:36,510 for telltale differences in another place... 118 00:06:38,880 --> 00:06:40,150 our brains. 119 00:06:40,150 --> 00:06:42,350 There are many studies finding differences 120 00:06:42,350 --> 00:06:44,720 between men and women, in brain structure, 121 00:06:44,720 --> 00:06:47,120 brain connectivity, brain function, 122 00:06:47,120 --> 00:06:49,720 and also in behaviors, attitudes, et cetera. 123 00:06:49,730 --> 00:06:51,930 But the question is whether these differences 124 00:06:51,930 --> 00:06:54,300 add up to create two types of people. 125 00:06:54,300 --> 00:06:56,230 Do the differences between the ways men 126 00:06:56,230 --> 00:06:57,800 and women behave trace back 127 00:06:57,800 --> 00:07:01,000 to physical differences in their brains? 128 00:07:01,000 --> 00:07:06,070 Science has asked this question for generations. 129 00:07:06,080 --> 00:07:09,980 In the 18th century, anatomists noticed that men, 130 00:07:09,980 --> 00:07:12,980 on average, had larger skulls. 131 00:07:12,980 --> 00:07:14,080 In the 19th century, 132 00:07:14,080 --> 00:07:15,980 they discovered that the brains of men 133 00:07:15,990 --> 00:07:18,790 tended to weigh more than those of women. 134 00:07:18,790 --> 00:07:22,820 These differences quickly become politicized. 135 00:07:22,830 --> 00:07:26,430 They started using this to explain female inferiority 136 00:07:26,430 --> 00:07:28,330 when they discovered that the brain 137 00:07:28,330 --> 00:07:29,760 of males were, on average, 138 00:07:29,770 --> 00:07:32,000 larger than the brains of females. 139 00:07:32,000 --> 00:07:34,200 Then again, this was used to explain 140 00:07:34,200 --> 00:07:36,740 why women are not as intelligent. 141 00:07:36,740 --> 00:07:38,170 There's a long history of science 142 00:07:38,170 --> 00:07:39,840 being used to justify 143 00:07:39,840 --> 00:07:42,910 and maintain the social order. 144 00:07:42,910 --> 00:07:45,480 Today, we think we're too sophisticated 145 00:07:45,480 --> 00:07:47,550 to make that mistake. 146 00:07:47,550 --> 00:07:51,890 Studies show that more men than women like soccer. 147 00:07:51,890 --> 00:07:53,820 We now know, that doesn't make soccer 148 00:07:53,820 --> 00:07:56,390 an exclusively male sport. 149 00:07:56,390 --> 00:07:57,930 But when we talk about the brain, 150 00:07:57,930 --> 00:08:01,130 we still fall back on male and female stereotypes. 151 00:08:01,130 --> 00:08:04,170 For example, scientists have found that, 152 00:08:04,170 --> 00:08:06,130 on average, a brain structure 153 00:08:06,140 --> 00:08:10,200 called the amygdala is larger in men. 154 00:08:10,210 --> 00:08:13,110 Because the amygdala is linked to aggression, 155 00:08:13,110 --> 00:08:16,840 you often hear people say aggression is a male trait. 156 00:08:16,850 --> 00:08:19,510 The idea that there is a male brain and female brain 157 00:08:19,520 --> 00:08:21,950 is so popular that people that write books 158 00:08:21,950 --> 00:08:24,920 about this get to be millionaires. 159 00:08:24,920 --> 00:08:28,490 These ideas depend on one big assumption... 160 00:08:28,490 --> 00:08:30,320 That you can look at any brain 161 00:08:30,330 --> 00:08:35,030 and tell whether it belongs to a man or a woman. 162 00:08:35,030 --> 00:08:38,330 Daphna set out to test whether this is really true. 163 00:08:38,330 --> 00:08:43,540 She analyzed MRI scans from more than 1,400 men and women. 164 00:08:43,540 --> 00:08:45,970 She wasn't looking at averages, 165 00:08:45,980 --> 00:08:49,080 she was looking at each individual brain. 166 00:08:51,480 --> 00:08:55,980 Imagine your brain is an ice-cream sundae. 167 00:08:55,990 --> 00:08:57,990 You get something blue for each brain structure 168 00:08:57,990 --> 00:09:00,190 that follows the male pattern. 169 00:09:00,190 --> 00:09:01,890 You get something pink 170 00:09:01,890 --> 00:09:05,130 for each structure that looks female. 171 00:09:05,130 --> 00:09:08,560 Many different brain structures go into the sundae. 172 00:09:08,570 --> 00:09:11,170 We assume that all the differences add up, 173 00:09:11,170 --> 00:09:14,940 one to the other, to create one type of person... 174 00:09:14,940 --> 00:09:18,310 Men with a male brain and woman with a female brain. 175 00:09:21,510 --> 00:09:25,250 Daphna's study put this idea to the test. 176 00:09:25,250 --> 00:09:28,280 If you're female, will every part of your brain 177 00:09:28,280 --> 00:09:32,120 look female in the MRI? 178 00:09:32,120 --> 00:09:37,490 If you're male, will every part of your brain look male? 179 00:09:37,490 --> 00:09:40,360 Looking at brains one by one, 180 00:09:40,360 --> 00:09:42,500 Daphna saw nothing like that. 181 00:09:42,500 --> 00:09:44,200 These sundaes should all look the same 182 00:09:44,200 --> 00:09:45,570 because they are all of women, 183 00:09:45,570 --> 00:09:47,570 but what we actually see when we look closely, 184 00:09:47,570 --> 00:09:49,270 is that most people had a brain 185 00:09:49,270 --> 00:09:52,110 which was a mosaic, mosaic of features. 186 00:09:52,110 --> 00:09:54,210 The majority of brains has a mixture of both male 187 00:09:54,210 --> 00:09:57,140 and female characteristics. 188 00:09:57,150 --> 00:09:58,880 Brains do not have sex, 189 00:09:58,880 --> 00:09:59,980 and we should stop using 190 00:09:59,980 --> 00:10:01,550 the male-brain/ female-brain idea 191 00:10:01,550 --> 00:10:04,390 to explain why men and women are fundamentally different, 192 00:10:04,390 --> 00:10:06,590 because they are not. 193 00:10:06,590 --> 00:10:11,930 In body and mind, we are all mosaics... 194 00:10:11,930 --> 00:10:17,100 Pixelated images of both man and woman. 195 00:10:17,100 --> 00:10:19,300 There's no denying that most of us grow up 196 00:10:19,300 --> 00:10:22,570 knowing which sex we are, 197 00:10:22,570 --> 00:10:25,740 but on a deep genetic level, 198 00:10:25,740 --> 00:10:27,540 we could be wrong. 199 00:10:31,780 --> 00:10:34,950 Where does our sex come from? 200 00:10:34,950 --> 00:10:36,650 Well, like any biological trait, 201 00:10:36,650 --> 00:10:39,850 the answer lies in our DNA. 202 00:10:39,860 --> 00:10:42,660 There are two sex chromosomes... 203 00:10:42,660 --> 00:10:44,660 One's called the x, 204 00:10:44,660 --> 00:10:48,130 and its little sidekick is the y. 205 00:10:48,130 --> 00:10:52,130 Usually, women have two x's, 206 00:10:52,140 --> 00:10:55,800 and men have one y and one x. 207 00:10:55,810 --> 00:10:59,640 But a small percentage of babies are born with chromosomes 208 00:10:59,640 --> 00:11:03,010 in neither of these arrangements. 209 00:11:03,010 --> 00:11:06,910 The more we learn about the biology of sex, 210 00:11:06,920 --> 00:11:11,220 the less it seems like there are only two sexes. 211 00:11:14,990 --> 00:11:16,920 Geneticist Eric Vilain works 212 00:11:16,930 --> 00:11:21,160 with an unusual group of patients. 213 00:11:21,160 --> 00:11:25,470 They do not fit our normal definitions of male and female. 214 00:11:28,200 --> 00:11:31,510 One term for them is "intersex." 215 00:11:31,510 --> 00:11:34,840 I see patients with intersex conditions. 216 00:11:34,840 --> 00:11:38,950 Their biological sex does not match 217 00:11:38,950 --> 00:11:42,220 their appearance, their chest, their genitals. 218 00:11:42,220 --> 00:11:44,350 And sometimes they're in between. 219 00:11:44,350 --> 00:11:47,690 Their genitalia are ambiguous. 220 00:11:47,690 --> 00:11:49,360 About one in 100 people 221 00:11:49,360 --> 00:11:52,360 have some degree of intersex condition. 222 00:11:52,360 --> 00:11:53,630 That's roughly the odds 223 00:11:53,630 --> 00:11:56,060 of having green eyes or red hair. 224 00:11:56,070 --> 00:12:00,100 While those qualities are visible to the naked eye, 225 00:12:00,100 --> 00:12:03,900 some intersex people aren't even aware of their condition. 226 00:12:03,910 --> 00:12:08,510 In his research, Eric found one particularly striking case. 227 00:12:08,510 --> 00:12:11,650 So, I had a patient, young girl, 17 years of age. 228 00:12:11,650 --> 00:12:13,710 Let's call her Eileen. 229 00:12:13,720 --> 00:12:15,220 And she came to my office 230 00:12:15,220 --> 00:12:17,450 because she didn't have any periods. 231 00:12:17,450 --> 00:12:19,690 Unlike all her friends, month after month, 232 00:12:19,690 --> 00:12:22,320 she was waiting... Nothing. 233 00:12:22,330 --> 00:12:25,960 Eileen looked like a completely typical girl... 234 00:12:25,960 --> 00:12:28,600 She was tall, she was good-looking, 235 00:12:28,600 --> 00:12:30,900 she was well put-together. 236 00:12:30,900 --> 00:12:33,600 Even though she looked completely female, 237 00:12:33,600 --> 00:12:36,900 there's one thing that was not working properly... 238 00:12:36,910 --> 00:12:38,670 She could not produce eggs, 239 00:12:38,670 --> 00:12:41,880 and she could not produce female hormones. 240 00:12:41,880 --> 00:12:44,650 We sent some tests for Eileen, 241 00:12:44,650 --> 00:12:47,750 and the first test we sent for her were chromosomes, 242 00:12:47,750 --> 00:12:48,950 and that's when we discovered 243 00:12:48,950 --> 00:12:52,220 that she had an x-y pair of chromosome, 244 00:12:52,220 --> 00:12:54,420 and not an x-x. 245 00:12:54,420 --> 00:12:56,920 Eileen was actually male... 246 00:12:56,930 --> 00:13:00,730 At least, according to her genes. 247 00:13:00,730 --> 00:13:05,170 The human genome is an incredibly complex molecule. 248 00:13:05,170 --> 00:13:07,800 It's the source of the many millions of instructions 249 00:13:07,800 --> 00:13:10,340 which our bodies follow as they grow. 250 00:13:10,340 --> 00:13:14,640 The determination of which sex we are is just one of them. 251 00:13:14,640 --> 00:13:16,710 In each cell of the human body, 252 00:13:16,710 --> 00:13:18,610 there are 46 chromosomes... 253 00:13:18,610 --> 00:13:20,350 Like this one... 254 00:13:20,350 --> 00:13:23,980 Containing millions of base pairs, 255 00:13:23,990 --> 00:13:29,590 but only one has something to do with determining sex. 256 00:13:29,590 --> 00:13:33,830 Our 46 chromosomes come in 23 pairs. 257 00:13:33,830 --> 00:13:35,960 Half of each pair comes from our mother, 258 00:13:35,970 --> 00:13:38,100 the other from our father. 259 00:13:38,100 --> 00:13:39,700 Within the chromosomes, 260 00:13:39,700 --> 00:13:42,440 our genes determine everything from eye color 261 00:13:42,440 --> 00:13:44,710 to the shape of our earlobes. 262 00:13:44,710 --> 00:13:47,270 Hidden among these pillars of our existence 263 00:13:47,280 --> 00:13:50,950 is one pair of sex chromosomes. 264 00:13:50,950 --> 00:13:52,480 Their combination determines 265 00:13:52,480 --> 00:13:55,850 whether we become male or female. 266 00:13:55,850 --> 00:14:00,520 Women are x-x, men... x-y. 267 00:14:00,520 --> 00:14:05,160 But if Eileen was male, why didn't she look male? 268 00:14:05,160 --> 00:14:08,160 Eric went looking for the root of the problem. 269 00:14:08,160 --> 00:14:11,600 We sent for another series of tests 270 00:14:11,600 --> 00:14:13,500 looking for mutations in genes 271 00:14:13,500 --> 00:14:16,270 important for sexual development. 272 00:14:16,270 --> 00:14:18,210 One of these tests looked 273 00:14:18,210 --> 00:14:21,880 for mutations in a critical gene on the y chromosome 274 00:14:21,880 --> 00:14:24,110 called SRY. 275 00:14:24,110 --> 00:14:25,650 On the y chromosome, 276 00:14:25,650 --> 00:14:28,280 there is this small gene called SRY 277 00:14:28,280 --> 00:14:33,090 that's only 887 base pairs in the determined sex. 278 00:14:33,090 --> 00:14:35,590 It was once believed that many genes 279 00:14:35,590 --> 00:14:38,460 on the y chromosome worked together 280 00:14:38,460 --> 00:14:41,130 in the womb to make you male. 281 00:14:41,130 --> 00:14:44,160 But we now know that the tiny SRY gene 282 00:14:44,170 --> 00:14:46,900 does that job all by itself. 283 00:14:46,900 --> 00:14:49,740 If SRY doesn't work correctly, 284 00:14:49,740 --> 00:14:51,970 the child can grow up looking female. 285 00:14:51,970 --> 00:14:55,140 We identified one base pair 286 00:14:55,140 --> 00:14:57,410 that was different in Eileen. 287 00:14:57,410 --> 00:15:00,510 This one mutation was responsible 288 00:15:00,520 --> 00:15:04,290 for her being not a boy. 289 00:15:04,290 --> 00:15:06,150 Out of three billion base pairs 290 00:15:06,160 --> 00:15:07,690 in the human genome, 291 00:15:07,690 --> 00:15:11,930 a single one had switched places with the one beside it. 292 00:15:11,930 --> 00:15:14,360 It's called a point mutation... 293 00:15:14,360 --> 00:15:19,730 The smallest possible alteration that can be made to a gene. 294 00:15:19,740 --> 00:15:21,840 Since mutations can be inherited, 295 00:15:21,840 --> 00:15:23,770 Eric invited Eileen's relatives 296 00:15:23,770 --> 00:15:25,610 to come for testing. 297 00:15:25,610 --> 00:15:29,740 He found two more females who were genetically x-y. 298 00:15:29,750 --> 00:15:32,350 Like Eileen, they had never had periods 299 00:15:32,350 --> 00:15:34,680 and could not bear children. 300 00:15:34,680 --> 00:15:37,850 Because of one tiny mutation, 301 00:15:37,850 --> 00:15:41,720 they'd lived as women for their entire lives. 302 00:15:41,720 --> 00:15:46,360 When it comes to SRY, the main sex-determining gene, 303 00:15:46,360 --> 00:15:47,860 there is no room for error. 304 00:15:47,860 --> 00:15:50,560 One base-pair mutation 305 00:15:50,570 --> 00:15:52,730 and the sexual development switches 306 00:15:52,740 --> 00:15:54,600 from male to female. 307 00:15:54,600 --> 00:15:56,170 For this handful of patients, 308 00:15:56,170 --> 00:15:58,140 along with millions of intersex people 309 00:15:58,140 --> 00:15:59,610 around the world, 310 00:15:59,610 --> 00:16:01,340 learning the truth about their genes 311 00:16:01,340 --> 00:16:04,350 can mark the beginning of a difficult process. 312 00:16:04,350 --> 00:16:06,750 They're really ashamed of their situation, 313 00:16:06,750 --> 00:16:10,020 and that's something that I can't stress enough. 314 00:16:10,020 --> 00:16:13,450 Despite the fact that these conditions are rare, 315 00:16:13,460 --> 00:16:14,920 they're not unique. 316 00:16:14,920 --> 00:16:16,260 If they're not alone, 317 00:16:16,260 --> 00:16:18,890 then this sense of shame disappears, 318 00:16:18,890 --> 00:16:21,760 and then they can embrace their conditions 319 00:16:21,760 --> 00:16:23,660 rather than be ashamed of it. 320 00:16:23,670 --> 00:16:25,530 Most of us can't imagine the anguish 321 00:16:25,530 --> 00:16:28,640 that the intersexed 1% must go through, 322 00:16:28,640 --> 00:16:32,840 but some people have even more challenging transitions... 323 00:16:32,840 --> 00:16:39,080 They hit puberty and their sex seems to suddenly switch. 324 00:16:41,060 --> 00:16:44,630 We all know that time changes us. 325 00:16:44,630 --> 00:16:49,860 First, we grow taller, then a little shorter. 326 00:16:49,870 --> 00:16:52,600 We lose our baby fat, 327 00:16:52,600 --> 00:16:56,540 and then we get a little of it back. 328 00:16:56,540 --> 00:17:03,680 But for most of us, one thing doesn't change... our sex. 329 00:17:03,680 --> 00:17:07,180 As we age, we learn to wear our masculinity 330 00:17:07,180 --> 00:17:11,690 and femininity like an old suit. 331 00:17:11,690 --> 00:17:14,360 But that's not true for everyone. 332 00:17:20,200 --> 00:17:23,400 Pediatric endocrinologist Chris Houk lives 333 00:17:23,400 --> 00:17:26,770 on 150 acres in south Carolina. 334 00:17:26,770 --> 00:17:29,940 In this grand laboratory of nature, 335 00:17:29,940 --> 00:17:34,040 he encourages his kids to study the birds and the bees. 336 00:17:34,040 --> 00:17:35,880 We live here with chickens 337 00:17:35,880 --> 00:17:38,250 and a horse and bees 338 00:17:38,250 --> 00:17:40,720 and soon-to-be goats. 339 00:17:40,720 --> 00:17:44,090 It allows kids to connect with nature. 340 00:17:44,090 --> 00:17:45,920 The eggs hatch, and then they grow up 341 00:17:45,920 --> 00:17:48,460 and become mature male or female, 342 00:17:48,460 --> 00:17:50,020 and then they make more babies. 343 00:17:50,030 --> 00:17:53,860 And the circle of life continues. 344 00:17:53,860 --> 00:17:56,860 Chris' research focuses on the biological process 345 00:17:56,870 --> 00:18:01,240 of growing up... How girls become women 346 00:18:01,240 --> 00:18:03,500 and boys become men. 347 00:18:03,510 --> 00:18:07,480 A few decades ago, some intriguing evidence emerged 348 00:18:07,480 --> 00:18:10,850 that not everyone follows those facts. 349 00:18:10,850 --> 00:18:12,280 Back in the early 70s, 350 00:18:12,280 --> 00:18:14,080 there was a rumor that circulated, 351 00:18:14,080 --> 00:18:17,090 that there was a village in the Dominican Republic 352 00:18:17,090 --> 00:18:20,820 where girls turned into boys at the age of puberty. 353 00:18:20,820 --> 00:18:22,690 The villagers seemed to know about this. 354 00:18:22,690 --> 00:18:24,990 They had multiple generations, 355 00:18:25,000 --> 00:18:26,390 seven or eight generations, 356 00:18:26,400 --> 00:18:28,300 that they could document at the time, 357 00:18:28,300 --> 00:18:30,970 to the point that they had created a terminology for it 358 00:18:30,970 --> 00:18:35,100 called "guevedoce," which means "penis at 12." 359 00:18:38,340 --> 00:18:40,110 Before their daughters hit puberty, 360 00:18:40,110 --> 00:18:41,880 the villagers trusted their eyes 361 00:18:41,880 --> 00:18:43,980 and raised them as girls. 362 00:18:43,980 --> 00:18:46,250 But when they hit puberty, 363 00:18:46,250 --> 00:18:49,880 sometimes things went a little haywire. 364 00:18:49,890 --> 00:18:54,220 Similar to humans, chickens go through puberty... 365 00:18:54,220 --> 00:18:57,360 Testosterone's what initiates chicken puberty 366 00:18:57,360 --> 00:18:58,890 and establishes sexual maturity, 367 00:18:58,900 --> 00:19:01,500 the ability to reproduce. 368 00:19:01,500 --> 00:19:04,000 To use this analogy, in guevedoce, 369 00:19:04,000 --> 00:19:06,430 a chick that appears to be becoming a hen 370 00:19:06,440 --> 00:19:09,100 takes on some of the secondary sexual characteristics 371 00:19:09,110 --> 00:19:11,810 that one would only see in a rooster. 372 00:19:11,810 --> 00:19:14,580 When researchers tested the guevedoces, 373 00:19:14,580 --> 00:19:17,980 they found high levels of testosterone, 374 00:19:17,980 --> 00:19:21,450 and their sex chromosomes were x-y. 375 00:19:21,450 --> 00:19:24,550 Biologically, they were male. 376 00:19:24,550 --> 00:19:29,620 Puberty had somehow revealed their underlying genetic sex. 377 00:19:29,630 --> 00:19:31,490 But how? 378 00:19:31,490 --> 00:19:32,760 Let's use this egg, for a moment, 379 00:19:32,760 --> 00:19:34,830 to talk about human development. 380 00:19:34,830 --> 00:19:37,100 We'll pretend that this egg is a womb. 381 00:19:37,100 --> 00:19:39,130 Within it is contained the fetus 382 00:19:39,140 --> 00:19:42,640 and all the materials needed to make a male or a female. 383 00:19:45,310 --> 00:19:47,880 If we wanted to make a female, this would be the end of it. 384 00:19:47,880 --> 00:19:49,910 We're done. We can scramble this up, 385 00:19:49,910 --> 00:19:52,410 we can sunny-side-up, we can over-medium. 386 00:19:52,420 --> 00:19:53,850 That is a girl egg. 387 00:19:53,850 --> 00:19:56,720 Making a female is a simple recipe... 388 00:19:56,720 --> 00:19:59,590 Just leave nature's goodness alone. 389 00:19:59,590 --> 00:20:03,320 But male development calls for more ingredients. 390 00:20:03,330 --> 00:20:05,660 At a very early time in human development, 391 00:20:05,660 --> 00:20:07,960 we would need to add testosterone, 392 00:20:07,960 --> 00:20:10,160 and that will have a tremendous effect. 393 00:20:10,170 --> 00:20:11,630 But if this is all you do, 394 00:20:11,630 --> 00:20:13,230 you're internal anatomy will be male, 395 00:20:13,240 --> 00:20:15,000 but no on will know it. 396 00:20:15,000 --> 00:20:18,010 In the guevedoces, this was the stage 397 00:20:18,010 --> 00:20:21,040 where male development went off course. 398 00:20:21,040 --> 00:20:24,110 They were missing a crucial extra ingredient. 399 00:20:24,110 --> 00:20:27,820 You need another, more potent activator of maleness, 400 00:20:27,820 --> 00:20:31,620 and that would be a hormone called DHT. 401 00:20:31,620 --> 00:20:35,260 This hormone is at least 100 times as potent 402 00:20:35,260 --> 00:20:36,890 as regular testosterone, 403 00:20:36,890 --> 00:20:40,060 and it's critical for what we call male development. 404 00:20:40,060 --> 00:20:41,960 In the womb, 405 00:20:41,970 --> 00:20:45,370 DHT is made from regular testosterone. 406 00:20:45,370 --> 00:20:49,070 It takes an enzyme called 5-Alpha reductase 407 00:20:49,070 --> 00:20:50,440 to do this job. 408 00:20:50,440 --> 00:20:53,140 In a normal male embryo, 409 00:20:53,140 --> 00:20:57,750 DHT creates structures we associate with maleness. 410 00:20:57,750 --> 00:21:01,850 At the end of the process, a baby boy is born. 411 00:21:01,850 --> 00:21:04,220 In guevedoces, a genetic mutation 412 00:21:04,220 --> 00:21:07,760 prevented them from making DHT. 413 00:21:07,760 --> 00:21:10,560 They looked female until puberty, 414 00:21:10,560 --> 00:21:12,490 when a surge of testosterone 415 00:21:12,500 --> 00:21:16,500 finally transformed their bodies into male ones. 416 00:21:16,500 --> 00:21:18,700 This strange discovery led researchers 417 00:21:18,700 --> 00:21:22,140 to a deep psychological question... 418 00:21:22,140 --> 00:21:25,640 How will a male see himself 419 00:21:25,640 --> 00:21:27,810 if he's raised as a girl? 420 00:21:27,810 --> 00:21:30,510 We have these two terms, "sex" and "gender." 421 00:21:30,510 --> 00:21:32,750 They're often used interchangeably. 422 00:21:32,750 --> 00:21:36,020 But to us in medicine, they are two distinct things. 423 00:21:36,020 --> 00:21:40,320 Sex generally refers to the physical appearance 424 00:21:40,320 --> 00:21:41,760 of an individual. 425 00:21:41,760 --> 00:21:43,860 Gender is something totally different. 426 00:21:43,860 --> 00:21:45,860 It's something sort of ethereal. 427 00:21:45,860 --> 00:21:47,600 It's this internal sense of "I'm a male" 428 00:21:47,600 --> 00:21:49,260 or "I'm a female" 429 00:21:49,270 --> 00:21:53,470 or "I'm neither, something in between." 430 00:21:55,570 --> 00:21:57,610 Well into the 20th century, 431 00:21:57,610 --> 00:21:59,440 gender was seen as something parents 432 00:21:59,440 --> 00:22:02,280 could assign to children. 433 00:22:02,280 --> 00:22:04,850 Raise a girl in a female role 434 00:22:04,850 --> 00:22:08,420 and she will see herself as female. 435 00:22:08,420 --> 00:22:10,250 But the children in this Dominican 436 00:22:10,250 --> 00:22:13,350 village shattered this idea. 437 00:22:13,360 --> 00:22:16,090 Of the guevedoces raised as female, 438 00:22:16,090 --> 00:22:20,600 95% transitioned to live as male. 439 00:22:20,600 --> 00:22:22,900 This sort of challenged that prevailing view 440 00:22:22,900 --> 00:22:25,700 that we could assign a gender. 441 00:22:25,700 --> 00:22:26,900 We could assign sex... 442 00:22:26,900 --> 00:22:28,870 You know, how you would raise the child... 443 00:22:28,870 --> 00:22:31,640 But you could not really assign gender, 444 00:22:31,640 --> 00:22:34,380 that there's something internal, 445 00:22:34,380 --> 00:22:36,740 something innate about gender. 446 00:22:38,750 --> 00:22:42,820 Our mental sense of whether we are male or female 447 00:22:42,820 --> 00:22:47,260 is not just an idea we get from the influence of others. 448 00:22:47,260 --> 00:22:51,960 Gender is rooted, biologically, deep inside us. 449 00:22:51,960 --> 00:22:54,000 So, what happens in our minds 450 00:22:54,000 --> 00:22:57,830 when our gender and our sex don't match? 451 00:23:00,600 --> 00:23:02,970 Biology says that sex 452 00:23:02,970 --> 00:23:06,940 is not as simple as male and female. 453 00:23:06,940 --> 00:23:09,810 Approximately 1 in 300 people 454 00:23:09,810 --> 00:23:13,910 identify themselves as transgender. 455 00:23:13,920 --> 00:23:16,850 Transgender people feel their biological sex 456 00:23:16,850 --> 00:23:21,420 doesn't match who they truly are up here, 457 00:23:21,420 --> 00:23:26,230 which raises a fascinating scientific question... 458 00:23:26,230 --> 00:23:29,330 Why do body and mind disagree? 459 00:23:35,840 --> 00:23:37,340 Transgender people are becoming 460 00:23:37,340 --> 00:23:39,440 much more visible in recent years 461 00:23:39,440 --> 00:23:43,210 thanks to evolving social norms. 462 00:23:43,210 --> 00:23:46,780 Many go to great lengths to alter their bodies, 463 00:23:46,780 --> 00:23:51,120 and ask their families to accept a different version of them. 464 00:23:51,120 --> 00:23:52,390 But where does the urge 465 00:23:52,390 --> 00:23:55,860 to change one's body come from? 466 00:23:55,860 --> 00:23:59,030 Neuroscientist Ivanka Savić is trying to understand 467 00:23:59,030 --> 00:24:03,130 the roots of transgender feelings in the brain. 468 00:24:03,130 --> 00:24:05,570 She studies how we perceive our bodies 469 00:24:05,570 --> 00:24:07,670 and feel at home in them. 470 00:24:07,670 --> 00:24:10,810 This is a very complex process for the brain 471 00:24:10,810 --> 00:24:13,240 because it involves several different areas 472 00:24:13,240 --> 00:24:16,910 that have to do with cognition, self. 473 00:24:16,910 --> 00:24:21,550 "Who am I?" Is a very high-level cognitive process. 474 00:24:21,550 --> 00:24:24,090 Ivanka believes this cognitive process 475 00:24:24,090 --> 00:24:26,990 might be different in transgender people. 476 00:24:26,990 --> 00:24:29,790 Transgender people, they look at themselves in the mirror 477 00:24:29,790 --> 00:24:33,360 every morning and feel uncomfortable 478 00:24:33,360 --> 00:24:35,860 because they, of course, recognize the image, 479 00:24:35,870 --> 00:24:40,100 but they don't feel this is the image that represents them. 480 00:24:40,100 --> 00:24:43,340 In a way, they see somebody else. 481 00:24:43,340 --> 00:24:45,310 As a neural scientist, 482 00:24:45,310 --> 00:24:47,040 Ivanka knows that connecting 483 00:24:47,040 --> 00:24:51,210 with your own body is a complex mental ballet. 484 00:24:51,210 --> 00:24:54,580 Our visual world overflows with information... 485 00:24:54,580 --> 00:24:57,220 Colors, forms, movements... 486 00:24:57,220 --> 00:25:00,620 But our brains impose a kind of order, 487 00:25:00,620 --> 00:25:04,060 identifying those things which are most important to us. 488 00:25:06,060 --> 00:25:09,030 It starts with the visual cortex, 489 00:25:09,030 --> 00:25:13,430 which takes in everything we see. 490 00:25:13,440 --> 00:25:14,700 That information flows 491 00:25:14,700 --> 00:25:17,910 to more specialized brain regions... 492 00:25:17,910 --> 00:25:23,480 One identifies bodies, another identifies faces. 493 00:25:23,480 --> 00:25:24,950 And yet another region, 494 00:25:24,950 --> 00:25:27,080 the temporo-parietal junction, 495 00:25:27,080 --> 00:25:31,290 identifies whether those faces and bodies belong to us. 496 00:25:31,290 --> 00:25:32,890 But it takes one more region 497 00:25:32,890 --> 00:25:36,390 to pull all these I.D.S together... 498 00:25:36,390 --> 00:25:39,160 The brain's identity center. 499 00:25:39,160 --> 00:25:42,800 The prefrontal cortex must conclude 500 00:25:42,800 --> 00:25:45,770 "this image feels like me." 501 00:25:45,770 --> 00:25:47,000 This is the mental network 502 00:25:47,000 --> 00:25:49,540 that allows us to recognize our own bodies 503 00:25:49,540 --> 00:25:51,510 and feel at home in them. 504 00:25:51,510 --> 00:25:54,610 And it operates completely unconsciously. 505 00:25:58,580 --> 00:26:01,120 This all-body perception is so automatic, 506 00:26:01,120 --> 00:26:05,720 so we don't even consciously reflect upon it. 507 00:26:05,720 --> 00:26:09,190 I look at my hand. It's my hand. 508 00:26:09,190 --> 00:26:12,930 I look at my face. It's my face. 509 00:26:12,930 --> 00:26:15,960 To recognize and know ourselves 510 00:26:15,970 --> 00:26:20,030 is something we take for granted everyday. 511 00:26:20,040 --> 00:26:25,170 But in some people, it may work a little differently. 512 00:26:25,170 --> 00:26:27,440 Many transgender people do not identify 513 00:26:27,440 --> 00:26:30,010 with the bodies they are born with. 514 00:26:30,010 --> 00:26:31,450 And in many cases, 515 00:26:31,450 --> 00:26:33,980 it doesn't seem to be a matter of choice. 516 00:26:33,980 --> 00:26:36,080 In many, many people who are transgender, 517 00:26:36,090 --> 00:26:39,420 this occurs very early during the childhood, 518 00:26:39,420 --> 00:26:40,450 and it's very strong. 519 00:26:40,460 --> 00:26:42,020 And that's why it's very important 520 00:26:42,020 --> 00:26:43,690 to take this seriously. 521 00:26:45,530 --> 00:26:48,300 Ivanka thought transgender people might see 522 00:26:48,300 --> 00:26:50,100 in their mind's eye 523 00:26:50,100 --> 00:26:53,730 a body that's different from their physical image. 524 00:26:53,740 --> 00:26:56,640 In an experiment, she showed transgender subjects 525 00:26:56,640 --> 00:26:58,870 photos of themselves. 526 00:26:58,880 --> 00:27:00,640 In some of these photos, 527 00:27:00,640 --> 00:27:02,910 she had subtlety altered their physiques. 528 00:27:02,910 --> 00:27:05,810 Many, many body images are presented 529 00:27:05,820 --> 00:27:07,680 during a very short time, 530 00:27:07,680 --> 00:27:10,250 and for each image, they have to determine 531 00:27:10,250 --> 00:27:13,020 "how much is it me?" 532 00:27:13,020 --> 00:27:17,020 Ivanka gave her subjects very little time to reflect, 533 00:27:17,030 --> 00:27:19,790 but they consistently identified with the photos 534 00:27:19,800 --> 00:27:23,500 that altered their outward sex characteristics, 535 00:27:23,500 --> 00:27:26,230 and they made their choices so quickly, 536 00:27:26,240 --> 00:27:28,600 Ivanka suspected the unconscious process 537 00:27:28,600 --> 00:27:30,240 of own-body perception 538 00:27:30,240 --> 00:27:33,040 was working differently for them. 539 00:27:33,040 --> 00:27:36,310 So she used MRI imaging to look 540 00:27:36,310 --> 00:27:40,680 at the connections in their brains. 541 00:27:40,680 --> 00:27:44,320 Think about what it takes to make a self-portrait. 542 00:27:44,320 --> 00:27:47,290 It's a dialogue between what your eyes tell you 543 00:27:47,290 --> 00:27:49,860 and what you think should be there. 544 00:27:49,860 --> 00:27:52,490 That's not unlike the unconscious dialogue 545 00:27:52,500 --> 00:27:55,560 that goes on between regions of your brain. 546 00:27:55,570 --> 00:27:57,200 People with transgender feelings 547 00:27:57,200 --> 00:28:00,000 don't have any visual impairment. 548 00:28:00,000 --> 00:28:03,270 They don't see the world any differently, 549 00:28:03,270 --> 00:28:05,570 but when Ivanka looked at their brains, 550 00:28:05,580 --> 00:28:07,010 she noticed two regions 551 00:28:07,010 --> 00:28:10,180 that weren't communicating in the usual way. 552 00:28:10,180 --> 00:28:13,510 We could see that there was a weaker connection 553 00:28:13,520 --> 00:28:15,820 between the area of the brain 554 00:28:15,820 --> 00:28:19,490 that represents self and the area of the brain 555 00:28:19,490 --> 00:28:22,490 that represents their own body. 556 00:28:22,490 --> 00:28:26,130 It could, somehow, explain these perceptions 557 00:28:26,130 --> 00:28:29,330 of seeing own body, recognize own body, 558 00:28:29,330 --> 00:28:30,530 but at the same time, 559 00:28:30,530 --> 00:28:33,970 feeling that this is not part of the self. 560 00:28:33,970 --> 00:28:36,170 The struggle to feel like yourself 561 00:28:36,170 --> 00:28:38,340 when you look at your own body 562 00:28:38,340 --> 00:28:42,010 is at the core of trans identity. 563 00:28:42,010 --> 00:28:44,310 Ivanka's research has uncovered the roots 564 00:28:44,310 --> 00:28:48,280 of this struggle in the brain. 565 00:28:48,280 --> 00:28:49,950 To live happier lives, 566 00:28:49,950 --> 00:28:52,620 transgender people often correct 567 00:28:52,620 --> 00:28:54,320 their physical appearance 568 00:28:54,320 --> 00:28:58,260 through hormone therapy or surgery. 569 00:28:58,260 --> 00:29:02,260 It's a tall order to switch sex anatomically, 570 00:29:02,260 --> 00:29:06,430 but new research is showing it soon could get easier 571 00:29:06,440 --> 00:29:09,440 because, on a hidden level, 572 00:29:09,440 --> 00:29:12,510 our bodies are constantly trying to switch. 573 00:29:16,400 --> 00:29:20,340 Hermaphrodite... it's an animal that has both male 574 00:29:20,340 --> 00:29:22,740 and female sex organs, 575 00:29:22,740 --> 00:29:25,080 like these snails. 576 00:29:25,080 --> 00:29:26,380 When they mate, 577 00:29:26,380 --> 00:29:28,750 either one can take on the biological role 578 00:29:28,750 --> 00:29:31,850 of the male or the female. 579 00:29:31,850 --> 00:29:33,350 New research is revealing 580 00:29:33,350 --> 00:29:38,560 that we all might be hermaphrodites, in a sense. 581 00:29:38,560 --> 00:29:41,090 Down at the level of our cells, 582 00:29:41,100 --> 00:29:44,000 there's a war between male and female 583 00:29:44,000 --> 00:29:46,670 raging inside all of us. 584 00:29:51,510 --> 00:29:53,670 Geneticist David Zarkower looks 585 00:29:53,670 --> 00:29:56,040 at how cells in our reproductive organs 586 00:29:56,040 --> 00:29:58,510 choose to be one sex or the other, 587 00:29:58,510 --> 00:30:02,110 and whether they can change their minds. 588 00:30:02,120 --> 00:30:05,150 Our interest is in how sexual differentiation happens, 589 00:30:05,150 --> 00:30:08,220 so how cells come to be either male or female. 590 00:30:08,220 --> 00:30:09,720 And so what we do is we find genes 591 00:30:09,720 --> 00:30:12,090 that might play an important role in that process, 592 00:30:12,090 --> 00:30:14,330 and we break them, and we see what happens. 593 00:30:17,700 --> 00:30:20,430 SRY is the gene on the y chromosome that decides 594 00:30:20,430 --> 00:30:22,130 whether you'll become male or female, 595 00:30:22,140 --> 00:30:25,500 and if SRY has been active, male development occurs. 596 00:30:25,510 --> 00:30:29,040 But David and his team decided to look beyond SRY 597 00:30:29,040 --> 00:30:33,780 to another gene called dmrt1. 598 00:30:33,780 --> 00:30:37,180 Dmrt1 helps the testes develop, 599 00:30:37,180 --> 00:30:41,620 but David wondered why it stayed active in adulthood. 600 00:30:41,620 --> 00:30:43,120 If the sex of male cells 601 00:30:43,120 --> 00:30:45,920 is supposed to be fixed before birth, 602 00:30:45,930 --> 00:30:50,160 why was this gene still working? 603 00:30:50,160 --> 00:30:53,100 David works on mice as stand-ins for humans, 604 00:30:53,100 --> 00:30:55,570 as their biology is very similar. 605 00:30:55,570 --> 00:30:58,340 And he did what geneticists do, 606 00:30:58,340 --> 00:31:00,570 he let mice grow to adulthood, 607 00:31:00,570 --> 00:31:05,080 then broke the dmrt1 gene to see what would happen. 608 00:31:05,080 --> 00:31:08,210 In this microscopy room, we look at mouse tissue samples, 609 00:31:08,220 --> 00:31:11,580 and we use specific stains to ask whether male- 610 00:31:11,590 --> 00:31:14,590 or female-specific proteins are active. 611 00:31:14,590 --> 00:31:17,560 The color scheme is simple... 612 00:31:17,560 --> 00:31:20,560 Green for male cells, pink for female. 613 00:31:20,560 --> 00:31:24,000 When David eliminated the dmrt1 gene 614 00:31:24,000 --> 00:31:26,600 then looked at the gonads of his mice, 615 00:31:26,600 --> 00:31:28,930 he saw something surprising. 616 00:31:28,940 --> 00:31:30,970 You can see that there's still some male cells... 617 00:31:30,970 --> 00:31:32,300 Which is these... But there are many, 618 00:31:32,310 --> 00:31:35,370 many more intensely pink staining cells. 619 00:31:35,380 --> 00:31:37,410 Deleting just one gene 620 00:31:37,410 --> 00:31:41,780 caused the cells to change sex. 621 00:31:41,780 --> 00:31:45,520 Ovaries were developing in the bodies of males. 622 00:31:45,520 --> 00:31:49,990 And he found this process works in both directions. 623 00:31:49,990 --> 00:31:51,590 At first we didn't really believe it, 624 00:31:51,590 --> 00:31:53,860 because this was supposed to be a testis, 625 00:31:53,860 --> 00:31:55,660 but there was all this expression 626 00:31:55,660 --> 00:31:56,960 of female-specific genes, 627 00:31:56,960 --> 00:31:58,660 and so we repeated the experiment, 628 00:31:58,670 --> 00:32:00,170 but it was clearly true. 629 00:32:00,170 --> 00:32:03,270 This testis was, essentially, directly transforming 630 00:32:03,270 --> 00:32:06,210 into something that was very much like an ovary. 631 00:32:06,210 --> 00:32:10,540 It's a discovery that shakes the very foundations of sex. 632 00:32:10,540 --> 00:32:13,550 The cells which makes us male or female 633 00:32:13,550 --> 00:32:16,880 don't have to stay that way. 634 00:32:16,880 --> 00:32:18,380 Could a woman produce sperm 635 00:32:18,390 --> 00:32:20,850 to make a baby with another woman? 636 00:32:20,860 --> 00:32:23,060 And could a man produce eggs? 637 00:32:26,360 --> 00:32:28,090 We all start with genes 638 00:32:28,100 --> 00:32:32,100 that could pull us toward male or female. 639 00:32:32,100 --> 00:32:34,500 For the first six weeks in the womb, 640 00:32:34,500 --> 00:32:37,500 a tenuous balance exists, 641 00:32:37,510 --> 00:32:39,270 neither side is winning. 642 00:32:39,270 --> 00:32:42,910 The embryo seems neither male nor female. 643 00:32:42,910 --> 00:32:44,680 But after six weeks, 644 00:32:44,680 --> 00:32:47,350 if the embryo has a y chromosome, 645 00:32:47,350 --> 00:32:51,980 the SRY gene kicks into action. 646 00:32:51,990 --> 00:32:55,620 The gene called SRY is the difference-maker. 647 00:32:58,290 --> 00:32:59,990 With SRY as anchor, 648 00:32:59,990 --> 00:33:02,590 the pro-male genes swing into action... 649 00:33:05,100 --> 00:33:08,770 Overwhelming their competition, 650 00:33:08,770 --> 00:33:12,000 pulling the fetus to develop as male. 651 00:33:15,810 --> 00:33:20,610 With sex determination complete, SRY hands over the reins. 652 00:33:22,750 --> 00:33:24,180 Here you go. 653 00:33:24,190 --> 00:33:30,960 Dmrt1 sees to it that a male child remains male. 654 00:33:30,960 --> 00:33:35,090 But if dmrt1 should ever leave his post, 655 00:33:35,100 --> 00:33:36,760 a gene called foxl2 656 00:33:36,760 --> 00:33:40,400 will seize the opportunity 657 00:33:40,400 --> 00:33:42,430 and start working to make the body... 658 00:33:42,440 --> 00:33:43,670 Let's go, ladies. 659 00:33:43,670 --> 00:33:45,370 Female. 660 00:33:47,910 --> 00:33:53,050 Like SRY, foxl2 spurs other genes into action... 661 00:33:53,050 --> 00:33:56,010 One, two, three, pull. 662 00:33:56,020 --> 00:33:59,520 Which overpower the male genes 663 00:33:59,520 --> 00:34:03,390 and start making female cells. 664 00:34:07,030 --> 00:34:11,260 We have this lifelong battle between dmrt1 and foxl2 665 00:34:11,270 --> 00:34:14,000 over whether the gonad will remain male 666 00:34:14,000 --> 00:34:16,240 or will, instead, become female. 667 00:34:16,240 --> 00:34:17,970 This is really different from the way 668 00:34:17,970 --> 00:34:19,570 we thought about things previously. 669 00:34:19,570 --> 00:34:21,670 Dave's genetic tinkering found a battle 670 00:34:21,680 --> 00:34:23,810 of the sexes going on inside us 671 00:34:23,810 --> 00:34:25,980 that never truly ends. 672 00:34:25,980 --> 00:34:29,550 In theory, an adult human body can be coaxed 673 00:34:29,550 --> 00:34:33,150 to make opposite-sex hormones. 674 00:34:33,150 --> 00:34:39,090 A new era of gender therapy is on the horizon. 675 00:34:39,090 --> 00:34:41,930 But consider the dark side. 676 00:34:41,930 --> 00:34:44,860 Could this technology be misused? 677 00:34:44,870 --> 00:34:46,630 Could people with anomalies 678 00:34:46,630 --> 00:34:48,770 in their sex chromosomes be forced 679 00:34:48,770 --> 00:34:51,800 to accept genetic alteration, 680 00:34:51,810 --> 00:34:53,970 to make them fit into traditional male 681 00:34:53,970 --> 00:34:55,840 and female molds? 682 00:34:55,840 --> 00:34:58,910 Children who are intersex may be coerced 683 00:34:58,910 --> 00:35:02,350 into being assigned one sex or the other. 684 00:35:02,350 --> 00:35:04,380 This has been a historical problem. 685 00:35:04,390 --> 00:35:06,650 This technology could potentially make that worse. 686 00:35:06,650 --> 00:35:10,020 So it'll have to be used responsibly. 687 00:35:10,020 --> 00:35:11,390 On the other hand, 688 00:35:11,390 --> 00:35:13,390 this new knowledge offers immense hope 689 00:35:13,390 --> 00:35:15,790 for transgender and intersex people 690 00:35:15,800 --> 00:35:19,400 who want to transition from one sex to another. 691 00:35:19,400 --> 00:35:21,630 The ultimate goal of gender transformation 692 00:35:21,640 --> 00:35:24,100 would be to allow somebody to become 693 00:35:24,100 --> 00:35:27,210 a reproductive individual of the opposite sex. 694 00:35:27,210 --> 00:35:29,240 It's a ways off, but now there's some reason to think 695 00:35:29,240 --> 00:35:31,880 that it might be possible for two men to have a baby, 696 00:35:31,880 --> 00:35:34,710 with one making sperm and the other one making eggs. 697 00:35:34,720 --> 00:35:36,950 Some day, our society 698 00:35:36,950 --> 00:35:41,150 may contain many new kinds of happy families. 699 00:35:41,160 --> 00:35:42,820 Our children may be born 700 00:35:42,820 --> 00:35:45,890 with more ways of changing their bodies' sex, 701 00:35:45,890 --> 00:35:48,390 if it doesn't seem to fit. 702 00:35:48,400 --> 00:35:50,760 Sex could soon be more fluid 703 00:35:50,760 --> 00:35:53,330 than we ever thought possible. 704 00:35:53,330 --> 00:35:55,430 But the animal kingdom is already showing 705 00:35:55,440 --> 00:35:57,170 that our understanding of sex 706 00:35:57,170 --> 00:35:59,710 could evolve even further. 707 00:35:59,710 --> 00:36:02,040 These scientists are exploring a world 708 00:36:02,040 --> 00:36:03,940 where making babies 709 00:36:03,940 --> 00:36:07,750 needs more than one male and one female. 710 00:36:11,640 --> 00:36:17,240 Sex and gender were long seen as male or female. 711 00:36:17,240 --> 00:36:19,340 However you thought of yourself, 712 00:36:19,340 --> 00:36:22,510 you could only use one bathroom door, 713 00:36:22,510 --> 00:36:26,350 but we now know the gender you feel you are 714 00:36:26,350 --> 00:36:29,280 can disagree with your anatomy. 715 00:36:29,290 --> 00:36:32,090 As a society, we're beginning to accept that sex 716 00:36:32,090 --> 00:36:33,690 and gender can be male, 717 00:36:33,690 --> 00:36:38,260 female, both, or somewhere in between. 718 00:36:38,260 --> 00:36:40,100 But in the future, 719 00:36:40,100 --> 00:36:44,730 we may choose to make sex even more complex than that, 720 00:36:44,740 --> 00:36:49,570 creating more than one type of male and female 721 00:36:49,570 --> 00:36:53,240 and even more possibilities in between. 722 00:37:00,990 --> 00:37:02,120 Good morning. 723 00:37:02,120 --> 00:37:03,450 Hey. Would you like to get a colony out? 724 00:37:03,450 --> 00:37:06,090 Sure. 725 00:37:06,090 --> 00:37:07,560 Biologist Joel Parker 726 00:37:07,560 --> 00:37:11,190 and evolutionary ecologist Sara Helms Cahan 727 00:37:11,200 --> 00:37:13,760 were once classmates. 728 00:37:13,760 --> 00:37:16,930 Now a tiny species has brought them back together... 729 00:37:20,000 --> 00:37:24,210 a species which could reveal where we ourselves are headed. 730 00:37:24,210 --> 00:37:25,670 - Okay. - Are you ready to touch 'em? 731 00:37:25,680 --> 00:37:28,840 - Yeah, well, don't get stung. Ah, remember... yes. 732 00:37:28,850 --> 00:37:31,010 You're braver than I am. 733 00:37:31,020 --> 00:37:32,900 I remember you were always squeamish about this. 734 00:37:35,790 --> 00:37:37,890 Throughout the desert southwest, 735 00:37:37,890 --> 00:37:40,790 there are many different species of seed-harvester ants. 736 00:37:40,790 --> 00:37:43,330 One of the most common is a pogonomyrmex. 737 00:37:43,330 --> 00:37:44,630 It means "bearded ant." 738 00:37:44,630 --> 00:37:47,660 "Pogo" meaning "beard." 739 00:37:47,670 --> 00:37:50,770 It was here, in the pogo's desert habitat, 740 00:37:50,770 --> 00:37:53,900 that Joel came across a paradox. 741 00:37:53,900 --> 00:37:56,610 He found two different species of pogos, 742 00:37:56,610 --> 00:37:59,140 a red type and a black type. 743 00:37:59,140 --> 00:38:01,540 Their colonies looked normal, 744 00:38:01,550 --> 00:38:03,880 with reproductive queens and males 745 00:38:03,880 --> 00:38:06,280 and hoards of sterile workers. 746 00:38:06,280 --> 00:38:09,350 But the two species shared a mysterious quirk. 747 00:38:09,350 --> 00:38:12,920 If you mated a queen with a male from her colony, 748 00:38:12,920 --> 00:38:16,230 you wouldn't get all the offspring the colony needed, 749 00:38:16,230 --> 00:38:18,990 you would only get female reproductives. 750 00:38:19,000 --> 00:38:20,900 You wouldn't get workers. 751 00:38:20,900 --> 00:38:23,500 So where did those workers all come from? 752 00:38:23,500 --> 00:38:26,130 Did they fall from outer space? 753 00:38:26,140 --> 00:38:28,200 Or did their appearance on the scene 754 00:38:28,210 --> 00:38:32,640 have a more earthy explanation? 755 00:38:32,640 --> 00:38:36,750 It was a mystery Joel and Sara were determined to solve. 756 00:38:36,750 --> 00:38:38,310 A normal ant colony gets started 757 00:38:38,320 --> 00:38:41,650 when a newly mated queen goes off after she mates 758 00:38:41,650 --> 00:38:43,290 and digs a little hole. 759 00:38:43,290 --> 00:38:45,950 She'll crawl into the hole then lay eggs 760 00:38:45,960 --> 00:38:50,030 that will become the first generation of workers. 761 00:38:50,030 --> 00:38:53,300 Workers are the backbone of an ant colony. 762 00:38:53,300 --> 00:38:56,030 These sisters forage for food 763 00:38:56,030 --> 00:38:58,270 and maintain the nest, 764 00:38:58,270 --> 00:39:01,070 but they can't reproduce. 765 00:39:01,070 --> 00:39:03,210 Reproductive females come later, 766 00:39:03,210 --> 00:39:06,070 and then the colony is established. 767 00:39:06,080 --> 00:39:08,510 They're cared for and fussed over 768 00:39:08,510 --> 00:39:11,780 like the future queens they are destined to be. 769 00:39:11,780 --> 00:39:15,980 You could think of them as princesses. 770 00:39:15,990 --> 00:39:20,790 And finally come the males, the colony's lowliest members. 771 00:39:20,790 --> 00:39:23,890 Males have a very sorry lot in the insect world. 772 00:39:23,890 --> 00:39:25,060 They're very small. 773 00:39:25,060 --> 00:39:27,000 They basically only have two functions in life... 774 00:39:27,000 --> 00:39:29,500 To fly and to mate. 775 00:39:29,500 --> 00:39:32,200 But mating for these two species 776 00:39:32,200 --> 00:39:35,500 is where the system appears to break down. 777 00:39:35,510 --> 00:39:37,470 Joel discovered that each species 778 00:39:37,470 --> 00:39:40,780 wasn't being faithful to its own kind. 779 00:39:40,780 --> 00:39:42,440 They were flying off to have flings 780 00:39:42,450 --> 00:39:46,280 with the species next door. 781 00:39:46,280 --> 00:39:48,120 In a pogo mating swarm, 782 00:39:48,120 --> 00:39:52,050 different couplings produce different types of offspring. 783 00:39:52,060 --> 00:39:54,990 When a female mates with her own species, 784 00:39:54,990 --> 00:39:57,730 she makes another reproductive female, 785 00:39:57,730 --> 00:39:59,190 a future queen. 786 00:39:59,200 --> 00:40:02,130 But to make one of the much-needed workers, 787 00:40:02,130 --> 00:40:05,830 she must mate with a male from the other species. 788 00:40:05,840 --> 00:40:08,140 Usually when you think of a sexual system, 789 00:40:08,140 --> 00:40:10,370 you think of males and females. 790 00:40:10,370 --> 00:40:12,440 With our ants, we have a situation 791 00:40:12,440 --> 00:40:14,480 where there's two different types of males 792 00:40:14,480 --> 00:40:15,840 and two different types of females 793 00:40:15,850 --> 00:40:19,350 that are required to keep this population going. 794 00:40:19,350 --> 00:40:22,120 So you can think of it as like one species, 795 00:40:22,120 --> 00:40:25,820 then, that has four different sexes. 796 00:40:25,820 --> 00:40:28,490 In a species with four sexes, 797 00:40:28,490 --> 00:40:32,490 there is more than simply male and female. 798 00:40:32,500 --> 00:40:34,960 Joel and Sara believe this system 799 00:40:34,970 --> 00:40:36,570 helps ants in a colony 800 00:40:36,570 --> 00:40:39,940 become more specialized in their roles, 801 00:40:39,940 --> 00:40:41,800 and they think it offers a preview 802 00:40:41,810 --> 00:40:44,070 of what may happen with humans, 803 00:40:44,070 --> 00:40:47,310 in the future. 804 00:40:47,310 --> 00:40:49,440 The thing that blows me away about ants is 805 00:40:49,450 --> 00:40:50,750 when you actually start looking at 'em 806 00:40:50,750 --> 00:40:52,250 from a biological point of view, 807 00:40:52,250 --> 00:40:56,790 they are more highly advanced evolutionarily than humans. 808 00:40:56,790 --> 00:41:00,590 Ants started farming 100 million years before we did. 809 00:41:00,590 --> 00:41:02,990 They don't have to be taught how to farm. 810 00:41:02,990 --> 00:41:05,190 It's all in their genes. 811 00:41:05,200 --> 00:41:08,430 We have ranching, we keep cattle. 812 00:41:08,430 --> 00:41:10,400 Ants tend their own kind of cattle, 813 00:41:10,400 --> 00:41:13,470 which are tiny little insects called aphids. 814 00:41:13,470 --> 00:41:17,910 We have soldiers that we send out to fight our wars. 815 00:41:17,910 --> 00:41:19,640 Ants also have soldiers 816 00:41:19,640 --> 00:41:22,440 that they send out to fight their wars. 817 00:41:26,850 --> 00:41:32,650 Where ants have gone, humanity has followed. 818 00:41:32,660 --> 00:41:36,660 Joel and Sara think it is happening again. 819 00:41:36,660 --> 00:41:39,560 Today, every human baby is made from the genes 820 00:41:39,560 --> 00:41:42,060 of just two people. 821 00:41:42,070 --> 00:41:43,530 But we are now experimenting 822 00:41:43,530 --> 00:41:45,770 with modifying the human genome, 823 00:41:45,770 --> 00:41:48,700 inserting genes from other sources. 824 00:41:48,710 --> 00:41:53,580 A baby made this way would have more than just two parents. 825 00:41:53,580 --> 00:41:56,710 I can't even think what our sexual system will be like 826 00:41:56,710 --> 00:41:58,850 when we start using some of these new technologies 827 00:41:58,850 --> 00:42:02,120 to put foreign DNA into our germ line. 828 00:42:02,120 --> 00:42:05,520 But when that happens, how many parents are we gonna have? 829 00:42:05,520 --> 00:42:07,220 I think we are going to move beyond 830 00:42:07,220 --> 00:42:11,590 the simple binary of mother and father. 831 00:42:11,600 --> 00:42:13,430 I could see it becoming more difficult 832 00:42:13,430 --> 00:42:16,260 to be able to easily define 833 00:42:16,270 --> 00:42:18,730 who is the parent of a given child. 834 00:42:22,740 --> 00:42:25,970 The poet Audre Lorde once wrote, 835 00:42:25,980 --> 00:42:29,680 "it is not our differences that divide us," 836 00:42:29,680 --> 00:42:33,280 it is our inability to recognize, accept, 837 00:42:33,280 --> 00:42:36,320 "and celebrate those differences." 838 00:42:36,320 --> 00:42:39,390 One day, we may find ourselves 839 00:42:39,390 --> 00:42:43,020 embracing a rainbow of different sex identities. 840 00:42:43,030 --> 00:42:47,230 Medical techniques could expand the definitions of sex 841 00:42:47,230 --> 00:42:52,370 and allow us to accelerate the evolution of our species. 842 00:42:52,370 --> 00:42:54,000 Perhaps the question isn't 843 00:42:54,000 --> 00:42:57,440 whether there are more than two sexes, 844 00:42:57,440 --> 00:43:00,440 but whether there are more possibilities 845 00:43:00,440 --> 00:43:01,910 than we ever imagined. 65331

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