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Would you like to inspect the original subtitles? These are the user uploaded subtitles that are being translated: 1 00:00:01,150 --> 00:00:04,369 Freeman: It is a nightmare that has stalked us for centuries. 2 00:00:06,855 --> 00:00:10,024 Hordes of human beings transformed 3 00:00:10,026 --> 00:00:12,794 into mindless, bloodthirsty monsters, 4 00:00:12,796 --> 00:00:16,364 and civilization collapses. [ Siren wailing ] 5 00:00:18,000 --> 00:00:20,802 Could this nightmare become reality? 6 00:00:26,809 --> 00:00:30,762 Scientists have discovered parasites that turn the living 7 00:00:30,764 --> 00:00:34,048 into the walking dead, 8 00:00:34,050 --> 00:00:40,405 and new strains of deadly pathogens attack us every year. 9 00:00:40,407 --> 00:00:44,058 Neuroscientists are learning how to take over our minds. 10 00:00:44,060 --> 00:00:49,731 Will we someday lose control of our bodies and souls? 11 00:00:49,733 --> 00:00:53,451 Is a zombie apocalypse possible? 12 00:00:58,791 --> 00:01:03,712 Space, time, life itself... 13 00:01:05,798 --> 00:01:10,385 The secrets of the cosmos lie through the wormhole. 14 00:01:10,387 --> 00:01:14,387 ♪ Through the Wormhole 05x06 ♪ Is a Zombie Apocalypse Possible? Original Air Date on June 25, 2014 15 00:01:14,388 --> 00:01:20,388 == sync, corrected by elderman == @elder_man 16 00:01:23,363 --> 00:01:25,498 According to Haitian folklore, 17 00:01:25,978 --> 00:01:28,845 certain priests had magical powders... 18 00:01:28,847 --> 00:01:33,367 [ Thunderclap ] That could transform a corpse... 19 00:01:33,369 --> 00:01:35,569 into a puppet. 20 00:01:35,571 --> 00:01:40,040 Our popular culture has turned that zombie legend 21 00:01:40,042 --> 00:01:42,743 into an apocalyptic nightmare, 22 00:01:42,745 --> 00:01:46,046 a contagious virus that turns the infected 23 00:01:46,048 --> 00:01:49,333 into violent monsters with rotting flesh. 24 00:01:49,335 --> 00:01:50,867 [ Thunderclap ] 25 00:01:50,869 --> 00:01:53,470 We are all just one bite away 26 00:01:53,472 --> 00:01:59,343 from joining the mindless legions of walking dead. 27 00:01:59,345 --> 00:02:02,096 All of these are myths, of course. 28 00:02:02,098 --> 00:02:03,380 [ Thunderclap ] 29 00:02:03,382 --> 00:02:07,484 But every myth has a grain of truth. 30 00:02:07,486 --> 00:02:08,902 Could our imaginations 31 00:02:08,904 --> 00:02:12,990 be telling us something about our future? 32 00:02:12,992 --> 00:02:14,725 [ Thunderclap ] 33 00:02:14,727 --> 00:02:17,227 Freeman: A long time ago, 34 00:02:17,229 --> 00:02:18,996 my friends and I saw a movie... [ Door creaks ] 35 00:02:18,998 --> 00:02:21,565 that gave us nightmares... [ All gasp ] 36 00:02:21,567 --> 00:02:23,534 "The Mummy." 37 00:02:23,536 --> 00:02:25,419 [ Children screaming ] In that story, 38 00:02:25,421 --> 00:02:27,788 ancient magic made a corpse walk the earth again. 39 00:02:29,624 --> 00:02:33,927 Could such a mindless monster ever exist in the real world? 40 00:02:38,416 --> 00:02:41,719 David Hughes is an entomologist. 41 00:02:41,721 --> 00:02:44,054 He has a long history 42 00:02:44,056 --> 00:02:47,057 with the dark side of that science. 43 00:02:47,059 --> 00:02:48,308 When I was a kid 44 00:02:48,310 --> 00:02:50,361 I had a rather personal relationship with a fungus. 45 00:02:50,363 --> 00:02:52,696 We didn't know exactly what it was at the beginning, 46 00:02:52,698 --> 00:02:54,431 and over the course of months, 47 00:02:54,433 --> 00:02:57,701 this fungus creeped its way across my scalp, 48 00:02:57,703 --> 00:02:59,486 uh, making me half bald. 49 00:03:00,989 --> 00:03:02,906 Freeman: David survived, 50 00:03:02,908 --> 00:03:06,994 but his fungus was not the worst nature has cooked up. 51 00:03:06,996 --> 00:03:11,448 Some funguses turned the bodies of their hosts into piles of rot 52 00:03:11,450 --> 00:03:14,785 and enslave their minds. 53 00:03:16,971 --> 00:03:19,840 David is the foremost expert on a fungus 54 00:03:19,842 --> 00:03:23,560 that turns its victims into the walking dead, 55 00:03:23,562 --> 00:03:28,298 or to be more accurate, the crawling dead. 56 00:03:28,300 --> 00:03:30,300 The fungus, like all organisms on the planet, 57 00:03:30,302 --> 00:03:31,518 has a scientific name. 58 00:03:31,520 --> 00:03:34,855 This one's called ophiocordyceps unitlateralis. 59 00:03:34,857 --> 00:03:37,741 But colloquially, it's known as the zombie ant fungi. 60 00:03:37,743 --> 00:03:40,160 Freeman: While foraging for food, 61 00:03:40,162 --> 00:03:41,578 an unsuspecting ant 62 00:03:41,580 --> 00:03:45,282 will pick up a spore of the zombie fungus. 63 00:03:45,284 --> 00:03:48,819 The fungus bores through the ant's body. 64 00:03:48,821 --> 00:03:51,955 It multiplies and infects the ant's brain, 65 00:03:51,957 --> 00:03:53,290 where it releases 66 00:03:53,292 --> 00:03:56,043 powerful mind-controlling chemicals. 67 00:03:57,429 --> 00:04:00,764 The zombified ant bites the underside of a leaf 68 00:04:00,766 --> 00:04:02,833 and dies. 69 00:04:02,835 --> 00:04:05,886 Well, sort of. 70 00:04:05,888 --> 00:04:08,505 Death is really the starting point for the parasite. 71 00:04:08,507 --> 00:04:10,524 Fungi are rather interesting 72 00:04:10,526 --> 00:04:13,393 in that they require the host to die, 73 00:04:13,395 --> 00:04:17,013 and then, from its tissues, they grow and they reproduce. 74 00:04:17,015 --> 00:04:18,315 And so, at this stage, 75 00:04:18,317 --> 00:04:21,685 the whole ant body is completely transformed. 76 00:04:23,905 --> 00:04:25,856 Freeman: The zombie ant fungus continues to control 77 00:04:25,858 --> 00:04:27,908 the dead creature's mind, 78 00:04:27,910 --> 00:04:31,695 keeping the insect's jaw locked onto the leaf. 79 00:04:31,697 --> 00:04:33,046 The fungus multiplies, 80 00:04:33,048 --> 00:04:35,365 building pressure inside the ant's skull 81 00:04:35,367 --> 00:04:40,053 until...it breaks open. 82 00:04:40,055 --> 00:04:43,807 Out comes a fungal stock that sprays down deadly spores 83 00:04:43,809 --> 00:04:47,311 on the fungus's next victims. 84 00:04:47,313 --> 00:04:49,980 The cycle repeats. 85 00:04:49,982 --> 00:04:52,516 The fungal spores need to be shot out, launched, 86 00:04:52,518 --> 00:04:56,103 from an area high above the foraging trail. 87 00:04:56,105 --> 00:04:58,555 And so the fungus has evolved the ability 88 00:04:58,557 --> 00:05:02,276 to control the mind of its host. 89 00:05:02,278 --> 00:05:06,730 Freeman: Inside their nests, ants are hygienic. 90 00:05:06,732 --> 00:05:08,699 But when they're out foraging, 91 00:05:08,701 --> 00:05:11,785 they are vulnerable to infection. 92 00:05:11,787 --> 00:05:15,005 David believes the fungus evolved the ability 93 00:05:15,007 --> 00:05:18,458 to strike the ants during this moment of weakness. 94 00:05:18,460 --> 00:05:23,213 The zombie ant fungus could never infect us. 95 00:05:23,215 --> 00:05:26,099 Our brains are too different from those of ants. 96 00:05:26,101 --> 00:05:30,687 But could a similar pathogen ever find its way into our mind? 97 00:05:30,689 --> 00:05:33,524 So fungi have clearly evolved the ability 98 00:05:33,526 --> 00:05:36,059 to control the behavior of animals. 99 00:05:36,061 --> 00:05:41,031 Our brains are animal brains, and there's no reason, 100 00:05:41,033 --> 00:05:43,867 theoretically, why we couldn't have our behavior controlled. 101 00:05:48,573 --> 00:05:52,576 Freeman: If a mind-enslaving pathogen ever strikes humanity, 102 00:05:52,578 --> 00:05:54,244 it will most likely jump to us 103 00:05:54,246 --> 00:05:57,648 from our close genetic relatives. 104 00:05:59,417 --> 00:06:04,788 Microbiologist Kartik Chandran studies the Ebola virus... 105 00:06:06,341 --> 00:06:09,760 A pathogen from our worst nightmares. 106 00:06:09,762 --> 00:06:11,261 Within weeks of infection, 107 00:06:11,263 --> 00:06:16,934 most patients leak blood from every orifice and die. 108 00:06:16,936 --> 00:06:19,486 Kartik is leading a team to find out 109 00:06:19,488 --> 00:06:24,691 how deadly viruses like Ebola evolve to infect humans. 110 00:06:26,194 --> 00:06:29,980 As far as we know, Ebola lives in bats, 111 00:06:29,982 --> 00:06:31,331 and every once in a while, 112 00:06:31,333 --> 00:06:34,150 this virus can break out from bats into other animals, 113 00:06:34,152 --> 00:06:37,537 including primates and apes and humans. 114 00:06:42,326 --> 00:06:44,378 Freeman: Kartik is investigating 115 00:06:44,380 --> 00:06:48,599 how Ebola made the jump from bats to us. 116 00:06:48,601 --> 00:06:51,685 He's imagining what it's like 117 00:06:51,687 --> 00:06:55,973 to be one of the microscopic bad guys. 118 00:06:57,225 --> 00:06:58,508 [ Static, door creaks ] 119 00:06:58,510 --> 00:07:00,176 The human body is a lot like a building 120 00:07:00,178 --> 00:07:02,062 where our cells are rooms. 121 00:07:02,064 --> 00:07:06,366 Viruses infect us by breaking and entering. 122 00:07:08,786 --> 00:07:10,904 So you might ask me, why does this little room 123 00:07:10,906 --> 00:07:12,706 in this storage facility have a lock? 124 00:07:12,708 --> 00:07:14,291 And so the answer is obvious -- 125 00:07:14,293 --> 00:07:16,693 because somebody needs to go in and out. 126 00:07:16,695 --> 00:07:19,162 This is an attempt to secure the entrance 127 00:07:19,164 --> 00:07:22,132 so that only the authorized individuals can get in. 128 00:07:22,134 --> 00:07:23,417 And cells are the same way. 129 00:07:23,419 --> 00:07:25,368 You know, cells need to bring stuff in, 130 00:07:25,370 --> 00:07:26,586 they need to export stuff, 131 00:07:26,588 --> 00:07:28,755 and viruses have really evolved to exploit 132 00:07:28,757 --> 00:07:31,141 this sort of entry and access ways. 133 00:07:31,143 --> 00:07:33,977 Freeman: Viruses mimic the shape of nutrients 134 00:07:33,979 --> 00:07:35,846 that the cell needs to survive, 135 00:07:35,848 --> 00:07:39,266 just like a lockpick mimics the shape of a key. 136 00:07:39,268 --> 00:07:42,235 [ Click, door rattling ] 137 00:07:42,237 --> 00:07:44,521 Freeman: Once inside the cell, 138 00:07:44,523 --> 00:07:48,058 the virus inserts its malicious genetic code. 139 00:07:48,060 --> 00:07:51,244 The host cell becomes an enslaved factory, 140 00:07:51,246 --> 00:07:54,448 producing countless copies of the invader. 141 00:07:54,450 --> 00:07:56,700 [ Screeching sound ] 142 00:07:56,702 --> 00:07:58,702 A multiplying virus can build so much pressure 143 00:07:58,704 --> 00:08:03,040 inside the host cell that it explodes... 144 00:08:03,042 --> 00:08:04,708 [ Explosion ] 145 00:08:04,710 --> 00:08:10,213 ...ejecting millions of viral clones to infect other cells. 146 00:08:11,916 --> 00:08:15,302 For a virus to jump from animal to human, 147 00:08:15,304 --> 00:08:19,056 it has to find a piece of biological machinery 148 00:08:19,058 --> 00:08:22,258 shared by both the animal and the human cell. 149 00:08:22,260 --> 00:08:25,062 Like you often see with viruses and other parasites, 150 00:08:25,064 --> 00:08:28,331 they evolve to co-opt these common cellular mechanisms, 151 00:08:28,333 --> 00:08:31,601 and Ebola has done just that. 152 00:08:31,603 --> 00:08:33,653 Freeman: Kartik made a groundbreaking discovery. 153 00:08:33,655 --> 00:08:39,826 Ebola relies on a protein called npc1 to infect cells. 154 00:08:39,828 --> 00:08:44,831 NPC1 is found in both bat and human cells. 155 00:08:44,833 --> 00:08:47,501 [ Chirping ] 156 00:08:47,503 --> 00:08:49,836 Bats and humans may seem very different, 157 00:08:49,838 --> 00:08:54,841 but their cells use remarkably similar molecular machinery. 158 00:08:54,843 --> 00:08:59,312 Most viruses that infect bats can also jump to humans. 159 00:08:59,314 --> 00:09:04,401 All a virus has to do is find those common keys. 160 00:09:04,403 --> 00:09:07,187 So, I mean, I think it's a probability thing. 161 00:09:07,189 --> 00:09:10,407 The more closely related you are to another organism, 162 00:09:10,409 --> 00:09:13,110 the more likely you are to pick up a virus. 163 00:09:13,112 --> 00:09:15,145 Freeman: A virus that turns human beings 164 00:09:15,147 --> 00:09:21,651 into violent, unconscious monsters already exists... 165 00:09:21,653 --> 00:09:22,653 Rabies. 166 00:09:22,654 --> 00:09:24,421 People that have rabies 167 00:09:24,423 --> 00:09:27,374 go through a phase where they're highly violent and belligerent, 168 00:09:27,376 --> 00:09:28,625 and they can foam at the mouth. 169 00:09:28,627 --> 00:09:30,093 These are changes that are -- 170 00:09:30,095 --> 00:09:32,328 clearly seem to benefit the virus 171 00:09:32,330 --> 00:09:34,347 in terms of its ability to spread 172 00:09:34,349 --> 00:09:38,101 from one infected host to a naive host. 173 00:09:39,687 --> 00:09:41,054 Freeman: A rabies infection 174 00:09:41,056 --> 00:09:44,775 does not spread easily from person to person. 175 00:09:44,777 --> 00:09:47,727 But if a virus like rabies mutated 176 00:09:47,729 --> 00:09:50,697 to have influenza-like properties, 177 00:09:50,699 --> 00:09:54,067 it could spread like wildfire. 178 00:10:00,625 --> 00:10:02,358 [ Coughing ] 179 00:10:02,360 --> 00:10:05,629 Freeman: The infected would mistake it for a common cold... 180 00:10:07,331 --> 00:10:09,416 ...until it's too late... 181 00:10:09,418 --> 00:10:12,702 [ Coughing ] 182 00:10:12,704 --> 00:10:15,722 Freeman: ...and they fall into a mindless rage. 183 00:10:23,481 --> 00:10:26,933 They would become violent and attack without warning. 184 00:10:26,935 --> 00:10:29,186 [ Strangled yell ] 185 00:10:29,188 --> 00:10:30,386 [ Stabbing sound ] 186 00:10:32,773 --> 00:10:35,725 [ Panting ] 187 00:10:35,727 --> 00:10:36,860 [ Gasps ] [ Banging on door ] 188 00:10:36,862 --> 00:10:40,747 Freeman: Open wounds would benefit the virus. 189 00:10:40,749 --> 00:10:45,168 It would easily transmit through airborne particles. 190 00:10:48,539 --> 00:10:50,507 [ Elevator bell dings ] 191 00:10:50,509 --> 00:10:54,094 Ironically, our own vigilant immune systems 192 00:10:54,096 --> 00:10:57,631 could help bring this virus into existence. 193 00:11:01,185 --> 00:11:02,919 Once a virus infects a cell, 194 00:11:02,921 --> 00:11:05,889 there is sort of this hardwired immune response 195 00:11:05,891 --> 00:11:08,925 that makes all these new machines in the cell 196 00:11:08,927 --> 00:11:10,977 that can try to stop the virus from infecting, 197 00:11:10,979 --> 00:11:12,646 and so the virus has got to evolve 198 00:11:12,648 --> 00:11:16,283 so it can get around these sort of antiviral proteins. 199 00:11:16,285 --> 00:11:19,035 Freeman: In the never-ending arms race 200 00:11:19,037 --> 00:11:22,272 between the virus and the host's immune system, 201 00:11:22,274 --> 00:11:24,741 both sides keep upping their game. 202 00:11:24,743 --> 00:11:28,778 As viruses mutate, they develop an array of evasive talents. 203 00:11:28,780 --> 00:11:33,884 In some mutations, viruses learn to become invisible. 204 00:11:33,886 --> 00:11:36,503 [ Switch clicks ] 205 00:11:36,505 --> 00:11:39,339 Other times, they evolve chemical tools 206 00:11:39,341 --> 00:11:43,293 that allow them to disable the body's infection monitors. 207 00:11:43,295 --> 00:11:45,362 [ Static ] 208 00:11:45,364 --> 00:11:49,099 Or if the virus mutates just right, 209 00:11:49,101 --> 00:11:54,854 it can permanently evade the immune system with a decoy. 210 00:11:57,308 --> 00:12:01,828 Eventually, a new form of the virus will evolve 211 00:12:01,830 --> 00:12:05,699 that can slip past the body's defenses. 212 00:12:05,701 --> 00:12:07,867 And that virus is selected because it's the only one 213 00:12:07,869 --> 00:12:10,420 that's able to grow and replicate itself 214 00:12:10,422 --> 00:12:12,005 in these cells, and so, all of a sudden, 215 00:12:12,007 --> 00:12:13,540 it takes over the whole population. 216 00:12:13,542 --> 00:12:17,260 So you go through these sort of, like, bursts of selection 217 00:12:17,262 --> 00:12:18,461 that completely change the -- 218 00:12:18,463 --> 00:12:20,380 sort of the structure of the viral population. 219 00:12:20,382 --> 00:12:23,166 And this can happen very quickly. 220 00:12:23,168 --> 00:12:25,468 Freeman: As long as we rely on our immune systems 221 00:12:25,470 --> 00:12:30,506 to keep us healthy, new viruses will constantly evolve. 222 00:12:30,508 --> 00:12:33,343 But a zombie virus may also 223 00:12:33,345 --> 00:12:37,230 one day be created in a laboratory. 224 00:12:37,232 --> 00:12:39,232 We should be able to design viruses 225 00:12:39,234 --> 00:12:40,617 that do different things. 226 00:12:40,619 --> 00:12:42,118 In principle, it seems to me 227 00:12:42,120 --> 00:12:44,354 that if you know what buttons to push, 228 00:12:44,356 --> 00:12:47,157 you could make a virus that could do those things. 229 00:12:47,159 --> 00:12:48,992 Freeman: Kartik, of course, 230 00:12:48,994 --> 00:12:52,078 wants to stop a zombie virus, not create one. 231 00:12:52,080 --> 00:12:55,198 But nothing is preventing the wrong minds 232 00:12:55,200 --> 00:12:56,549 from pursuing it. 233 00:12:56,551 --> 00:12:58,534 Is a zombie virus possible? 234 00:12:58,536 --> 00:13:00,670 I mean, I suppose there's really nothing in the laws of physics 235 00:13:00,672 --> 00:13:02,538 that says it's impossible, 236 00:13:02,540 --> 00:13:04,207 although I would say that it could be 237 00:13:04,209 --> 00:13:05,508 some sort of combination 238 00:13:05,510 --> 00:13:08,311 of different viruses that we know about. 239 00:13:08,313 --> 00:13:11,982 Freeman: A hybrid virus that turns human beings 240 00:13:11,984 --> 00:13:15,652 into deadly, contagious monsters is not likely, 241 00:13:15,654 --> 00:13:18,405 but it is possible. 242 00:13:18,407 --> 00:13:20,940 It could come from a laboratory, 243 00:13:20,942 --> 00:13:24,894 or could be born from the crucible of evolution. 244 00:13:24,896 --> 00:13:29,949 If this virus breaks out, what happens next? 245 00:13:31,731 --> 00:13:35,317 When you get the flu, what do you do? 246 00:13:36,319 --> 00:13:41,405 Go home, get in bed, and hope no one bothers you. 247 00:13:41,407 --> 00:13:43,491 But imagine a disease that spreads 248 00:13:43,493 --> 00:13:47,311 by making its victims violent. 249 00:13:47,313 --> 00:13:51,198 Such a disease could emerge someday. 250 00:13:51,200 --> 00:13:56,087 Could we keep it from becoming a global pandemic? 251 00:13:57,655 --> 00:13:59,090 In Ottawa, Canada, 252 00:13:59,092 --> 00:14:02,543 a scientist is taking on the zombie apocalypse 253 00:14:02,545 --> 00:14:04,879 before it happens. 254 00:14:04,881 --> 00:14:07,381 [ Beeps ] 255 00:14:07,383 --> 00:14:14,722 A scientist who always seems to have a question on his mind. 256 00:14:14,724 --> 00:14:16,673 I added the question mark because my name was very boring, 257 00:14:16,675 --> 00:14:18,609 and I was getting confused with all kinds of Robert Smiths, 258 00:14:18,611 --> 00:14:20,811 so I thought it'd be a cool thing to add to my name. 259 00:14:20,813 --> 00:14:23,680 And because I have my question mark which helps me 260 00:14:23,682 --> 00:14:25,232 be distinguished from other Robert Smiths 261 00:14:25,234 --> 00:14:28,619 in my specific field of disease modeling by mathematics. 262 00:14:33,041 --> 00:14:35,042 Freeman: Diseases are everywhere. 263 00:14:35,044 --> 00:14:36,911 [ Coughs ] Robert wants to log 264 00:14:36,913 --> 00:14:39,296 every moment in his life... [ Cell phone rings, beeps ] 265 00:14:39,298 --> 00:14:42,699 When he can pick up a pathogen from an infected person, 266 00:14:42,701 --> 00:14:46,637 even when the infected aren't around. 267 00:14:46,639 --> 00:14:48,756 [ Water streaming ] If a disease is airborne, 268 00:14:48,758 --> 00:14:50,341 then the air that we share 269 00:14:50,343 --> 00:14:52,676 is obviously something that's potentially quite toxic. 270 00:14:52,678 --> 00:14:54,478 [ Cell phone rings, beeps ] And the closer you are, 271 00:14:54,480 --> 00:14:55,712 of course, the more likely. 272 00:14:55,714 --> 00:14:57,714 But then other things become transmissible as well. 273 00:14:57,716 --> 00:15:00,985 So doorknobs and, you know... [ Cell phone rings ] 274 00:15:00,987 --> 00:15:03,554 [ Beep ] The handle of whatever it is 275 00:15:03,556 --> 00:15:05,856 that I'm touching or breathing on. 276 00:15:05,858 --> 00:15:07,191 [ Cell phone rings ] 277 00:15:07,193 --> 00:15:11,895 [ Beeping ] 278 00:15:11,897 --> 00:15:13,697 Freeman: Robert is using this data 279 00:15:13,699 --> 00:15:16,534 to build mathematical models to predict 280 00:15:16,536 --> 00:15:20,737 how quickly infectious diseases can spread. 281 00:15:20,739 --> 00:15:22,289 And with the help of his students, 282 00:15:22,291 --> 00:15:27,411 he's creating live human versions of those models. 283 00:15:27,413 --> 00:15:29,630 Just like any human community, 284 00:15:29,632 --> 00:15:33,184 the virus has many chances to find a new host. 285 00:15:33,186 --> 00:15:36,253 Okay, in these beakers, most of them are just plain water. 286 00:15:36,255 --> 00:15:37,555 One of them has been infected 287 00:15:37,557 --> 00:15:40,391 with something that's gonna simulate a virus. 288 00:15:40,393 --> 00:15:43,027 Freeman: The rules are simple. 289 00:15:43,029 --> 00:15:45,813 No student can take more than five steps. 290 00:15:45,815 --> 00:15:47,781 Ready? And go. [ Blows whistle ] 291 00:15:47,783 --> 00:15:49,933 Freeman: They have 30 seconds to mix 292 00:15:49,935 --> 00:15:52,403 with as many other students as possible, 293 00:15:52,405 --> 00:15:54,938 and no one knows who has the beaker 294 00:15:54,940 --> 00:15:56,490 with the infection. 295 00:15:56,492 --> 00:16:02,446 Robert wants to see how many people patient zero can infect. 296 00:16:02,448 --> 00:16:05,782 [ Toot ] 297 00:16:05,784 --> 00:16:08,302 Okay, now please return your beakers to the middle. 298 00:16:09,671 --> 00:16:11,005 Freeman: At the end of the game, 299 00:16:11,007 --> 00:16:13,924 Robert drops a chemical into each beaker. 300 00:16:13,926 --> 00:16:16,627 If a student mixed with the infected, 301 00:16:16,629 --> 00:16:18,596 their water will turn yellow. 302 00:16:18,598 --> 00:16:20,297 Even though patient zero 303 00:16:20,299 --> 00:16:23,901 could only have direct contact with a few neighbors, 304 00:16:23,903 --> 00:16:25,802 those neighbors passed the disease along, 305 00:16:25,804 --> 00:16:29,306 and about half the group ends up infected. 306 00:16:29,308 --> 00:16:35,479 But Robert believes the math desperately needs an update. 307 00:16:35,481 --> 00:16:37,281 So recently, we tried to update models, 308 00:16:37,283 --> 00:16:39,533 and we have much more powerful ways of understanding 309 00:16:39,535 --> 00:16:41,952 the network of connections that different people have. 310 00:16:41,954 --> 00:16:43,287 [ Film projector whirring ] 311 00:16:43,289 --> 00:16:45,923 Freeman: The old models focused on human beings 312 00:16:45,925 --> 00:16:48,626 and their local communities. 313 00:16:48,628 --> 00:16:52,162 But we now live in a global society 314 00:16:52,164 --> 00:16:54,465 and are on the move like never before. 315 00:16:54,467 --> 00:16:59,169 On an average day, approximately 22.8 million of us 316 00:16:59,171 --> 00:17:03,340 travel someplace far away. 317 00:17:05,393 --> 00:17:08,729 Robert repeats the game with the same rules, 318 00:17:08,731 --> 00:17:10,514 but this time, the students are allowed 319 00:17:10,516 --> 00:17:13,150 to take as many steps as they wish 320 00:17:13,152 --> 00:17:16,570 to account for the ease with which we travel. 321 00:17:16,572 --> 00:17:18,289 [ Toot ] 322 00:17:25,714 --> 00:17:27,364 [ Toot ] 323 00:17:30,585 --> 00:17:33,053 Freeman: At the end of the 30-second round, 324 00:17:33,055 --> 00:17:36,707 Robert tests each beaker again. 325 00:17:39,094 --> 00:17:42,212 Every student is infected. 326 00:17:42,214 --> 00:17:44,381 Robert has calculated 327 00:17:44,383 --> 00:17:48,051 the infection rate for a disease that doesn't yet exist. 328 00:17:48,053 --> 00:17:52,323 He imagines a virus that spreads easily through the air, 329 00:17:52,325 --> 00:17:53,524 like the flu. 330 00:17:53,526 --> 00:17:55,159 But unlike influenza, 331 00:17:55,161 --> 00:17:58,028 the disease does not make its victims 332 00:17:58,030 --> 00:17:59,896 want to stay home in bed. 333 00:17:59,898 --> 00:18:03,450 Instead, they become zombies, 334 00:18:03,452 --> 00:18:07,338 and they take to the streets in a mindless rage. 335 00:18:07,340 --> 00:18:08,672 [ Snarls ] 336 00:18:08,674 --> 00:18:10,040 So if we actually had a zombie virus, 337 00:18:10,042 --> 00:18:11,508 then the mathematics predicts 338 00:18:11,510 --> 00:18:13,377 that we're not gonna do very well. 339 00:18:13,379 --> 00:18:16,013 [ Sirens wailing ] 340 00:18:16,015 --> 00:18:19,133 Freeman: If just one person is infected with this zombie virus, 341 00:18:19,135 --> 00:18:23,086 Robert predicts an epidemic is inevitable. 342 00:18:23,088 --> 00:18:26,256 Cities would be overrun in weeks. 343 00:18:26,258 --> 00:18:27,858 [ Crowd shouting indistinctly ] 344 00:18:27,860 --> 00:18:29,476 Freeman: As refugees escape, 345 00:18:29,478 --> 00:18:33,564 some of them inadvertently bring the disease along. 346 00:18:33,566 --> 00:18:36,066 Global civilization as we know it 347 00:18:36,068 --> 00:18:39,603 would be brought to its knees in a matter of months. 348 00:18:39,605 --> 00:18:44,575 We have completely eradicated only two infectious diseases -- 349 00:18:44,577 --> 00:18:46,943 cattle plague and smallpox. 350 00:18:46,945 --> 00:18:50,164 Finding a cure for this hypothetical zombie virus 351 00:18:50,166 --> 00:18:53,167 is very unlikely. 352 00:18:53,169 --> 00:18:56,286 But if a zombie outbreak does happen, 353 00:18:56,288 --> 00:18:58,005 Robert's calculations 354 00:18:58,007 --> 00:19:01,842 show how humans can avoid total annihilation... 355 00:19:02,960 --> 00:19:06,630 by getting our hands dirty. 356 00:19:06,632 --> 00:19:09,066 Probably the best way that we found to deal with zombies 357 00:19:09,068 --> 00:19:11,185 was to basically hit them hard and hit them often. 358 00:19:12,737 --> 00:19:15,972 So the idea is that you try and wipe the zombies out in one go, 359 00:19:15,974 --> 00:19:17,274 and of course, you're not gonna be successful at that, 360 00:19:17,276 --> 00:19:19,643 so, next day, you try and wipe them out again, 361 00:19:19,645 --> 00:19:21,645 using the knowledge that you learned from the last time. 362 00:19:21,647 --> 00:19:23,146 So we get better at it, 363 00:19:23,148 --> 00:19:26,333 and so then the third day, we're now even better. 364 00:19:26,335 --> 00:19:30,087 Freeman: To stop a zombie plague from becoming an apocalypse, 365 00:19:30,089 --> 00:19:33,657 we may only have one horrifying option -- 366 00:19:33,659 --> 00:19:39,046 to kill every single infected person. 367 00:19:39,048 --> 00:19:45,769 Just one surviving zombie could trigger another epidemic. 368 00:19:45,771 --> 00:19:48,171 Our best hope to stop a super virus 369 00:19:48,173 --> 00:19:51,174 is to catch it in time. 370 00:19:51,176 --> 00:19:54,027 Virus hunters are scouring the microscopic world, 371 00:19:54,029 --> 00:19:55,946 looking for an invisible enemy 372 00:19:55,948 --> 00:20:00,367 that may have already made its first move. 373 00:20:02,883 --> 00:20:06,152 During the four years of World War I, 374 00:20:06,154 --> 00:20:10,756 almost 15 million people died. 375 00:20:10,758 --> 00:20:12,925 In the two years that followed, 376 00:20:12,927 --> 00:20:18,664 a single flu virus claimed three times that many lives. 377 00:20:18,666 --> 00:20:21,634 The virus had spread around the world 378 00:20:21,636 --> 00:20:24,387 before anyone detected it. 379 00:20:24,389 --> 00:20:27,256 There are millions of microbes out there, 380 00:20:27,258 --> 00:20:29,875 most of them harmless. 381 00:20:29,877 --> 00:20:33,512 How can we find the next deadly pandemic, 382 00:20:33,514 --> 00:20:35,681 perhaps a zombie virus... 383 00:20:35,683 --> 00:20:38,550 [ Imitates gunshot ] 384 00:20:38,552 --> 00:20:42,104 ...before it sweeps the globe? 385 00:20:42,106 --> 00:20:44,657 [ Blows air ] 386 00:20:44,659 --> 00:20:48,461 [ Wind blowing loudly ] 387 00:20:48,463 --> 00:20:50,930 Hello? 388 00:20:50,932 --> 00:20:53,399 Hello? 389 00:20:53,401 --> 00:20:54,934 Freeman: According to Ian Lipkin, 390 00:20:54,936 --> 00:20:57,569 the world's leading virus hunter, 391 00:20:57,571 --> 00:21:02,407 our civilization runs a terrible risk of global pandemic. 392 00:21:02,409 --> 00:21:05,377 I'm standing in the middle of Times Square, 393 00:21:05,379 --> 00:21:07,346 and it's completely deserted. 394 00:21:07,348 --> 00:21:10,916 It looks like something that you might see in a movie, 395 00:21:10,918 --> 00:21:12,968 but, in fact, it's a real possibility. 396 00:21:14,754 --> 00:21:16,138 Freeman: Ian is the director 397 00:21:16,140 --> 00:21:18,590 for the Center for Infection and Immunity 398 00:21:18,592 --> 00:21:21,093 at Columbia University. 399 00:21:21,095 --> 00:21:23,229 His team is on the front lines, 400 00:21:23,231 --> 00:21:27,599 hunting for deadly viruses before they become pandemics. 401 00:21:27,601 --> 00:21:30,236 In 2003, his lab was the first 402 00:21:30,238 --> 00:21:33,405 to identify the lethal S.A.R.S. virus. 403 00:21:33,407 --> 00:21:38,294 That early discovery saved countless lives. 404 00:21:38,296 --> 00:21:41,964 Nature herself is continually evolving new bacteria, 405 00:21:41,966 --> 00:21:44,750 new viruses that are more pathogenic, 406 00:21:44,752 --> 00:21:48,120 that escape the antivirals, the antibacterials, 407 00:21:48,122 --> 00:21:51,674 the vaccines that we create to hold them in check. 408 00:21:51,676 --> 00:21:52,758 [ Coughs ] 409 00:21:52,760 --> 00:21:54,760 Freeman: There are more 410 00:21:54,762 --> 00:21:59,398 than 10,000 trillion trillion trillion viruses on earth. 411 00:21:59,400 --> 00:22:03,486 Pinpointing a deadly virus in a sea of its benign cousins 412 00:22:03,488 --> 00:22:06,655 is just about impossible, 413 00:22:06,657 --> 00:22:10,943 unless you lure the virus out of hiding. 414 00:22:10,945 --> 00:22:13,245 When a patient falls ill somewhere in the world 415 00:22:13,247 --> 00:22:15,080 with an unknown virus, 416 00:22:15,082 --> 00:22:16,982 blood and other biological samples 417 00:22:16,984 --> 00:22:19,818 are often sent to Ian's lab. 418 00:22:19,820 --> 00:22:25,708 He then gets to work by going fishing with D.N.A. 419 00:22:28,845 --> 00:22:32,381 D.N.A. makes for the perfect virus bait, 420 00:22:32,383 --> 00:22:33,966 because viruses contain genetic code 421 00:22:33,968 --> 00:22:38,387 that binds to matching sequences of D.N.A. 422 00:22:38,389 --> 00:22:41,974 So then if that virus is present within that sample, 423 00:22:41,976 --> 00:22:44,009 it will be caught on the hook, 424 00:22:44,011 --> 00:22:47,279 and I'll be able to reel it in, and I'll see it. 425 00:22:47,281 --> 00:22:50,950 Freeman: Ian can cast thousands of genetic lures 426 00:22:50,952 --> 00:22:52,234 into the sample. 427 00:22:53,853 --> 00:22:57,189 Each one is tailored to attract a known virus. 428 00:22:57,191 --> 00:22:58,407 [ Screeches ] 429 00:22:58,409 --> 00:23:00,543 Freeman: Biological samples from sick patients 430 00:23:00,545 --> 00:23:04,663 are oceans filled with microbes that ignore the lure, 431 00:23:04,665 --> 00:23:07,532 except for the virus that is a match 432 00:23:07,534 --> 00:23:09,752 for the lure's D.N.A. sequence. 433 00:23:11,304 --> 00:23:13,872 The virus lines up its genetic code -- 434 00:23:13,874 --> 00:23:18,594 A binds to T, C binds to G. 435 00:23:18,596 --> 00:23:20,095 Once it's hooked... Uh-oh. 436 00:23:20,097 --> 00:23:22,264 The weight of the lure changes, 437 00:23:22,266 --> 00:23:25,017 and Ian can reel in the virus. 438 00:23:25,019 --> 00:23:26,551 [ Seagulls crying ] 439 00:23:26,553 --> 00:23:27,987 [ Click ] 440 00:23:27,989 --> 00:23:31,323 Now, if that method works, then we can get an answer 441 00:23:31,325 --> 00:23:33,943 very, very quickly, very inexpensively, 442 00:23:33,945 --> 00:23:37,746 probably in a matter of four to six hours at the outside. 443 00:23:37,748 --> 00:23:39,615 Freeman: But viral and genetic code 444 00:23:39,617 --> 00:23:41,667 can evolve rapidly. 445 00:23:41,669 --> 00:23:44,670 Sometimes new viruses have changed so much 446 00:23:44,672 --> 00:23:47,406 that they no longer stick to the lure. 447 00:23:47,408 --> 00:23:50,876 In that case, Ian switches to another technique -- 448 00:23:50,878 --> 00:23:53,128 grab all the D.N.A. he can. 449 00:23:53,130 --> 00:23:54,413 I have a net. 450 00:23:54,415 --> 00:23:57,749 This is essentially a D.N.A. sequence. 451 00:23:57,751 --> 00:24:00,519 When we don't know precisely what we're looking for, 452 00:24:00,521 --> 00:24:02,805 we use a high-throughput sequencer 453 00:24:02,807 --> 00:24:05,924 that allows us to characterize all of the genetic material 454 00:24:05,926 --> 00:24:08,727 that'd be present within a sample. 455 00:24:08,729 --> 00:24:10,613 We pull everything in, and then we compare that 456 00:24:10,615 --> 00:24:13,482 with a database of all known sequences. 457 00:24:13,484 --> 00:24:15,534 That allows us to identify anything 458 00:24:15,536 --> 00:24:18,487 which is potentially a microbial agent. 459 00:24:18,489 --> 00:24:19,989 Freeman: Ian and his team 460 00:24:19,991 --> 00:24:23,375 then grow colonies of the isolated virus 461 00:24:23,377 --> 00:24:25,377 and attempt either to identify a drug 462 00:24:25,379 --> 00:24:31,383 that can fight the infection or to develop a vaccine. 463 00:24:31,385 --> 00:24:35,454 We and our colleagues can begin testing drugs for efficacy, 464 00:24:35,456 --> 00:24:37,673 drugs that will be able to prevent this agent 465 00:24:37,675 --> 00:24:39,558 from reproducing itself. 466 00:24:39,560 --> 00:24:41,260 And then, ultimately, 467 00:24:41,262 --> 00:24:43,962 because drugs are frequently too expensive, 468 00:24:43,964 --> 00:24:46,131 we try to collaborate with people 469 00:24:46,133 --> 00:24:48,300 who know how to develop vaccines. 470 00:24:48,302 --> 00:24:49,935 Freeman: No matter how quickly 471 00:24:49,937 --> 00:24:52,354 they identify new viruses, however, 472 00:24:52,356 --> 00:24:56,641 there will always be a lag time between detection and treatment, 473 00:24:56,643 --> 00:24:59,244 a time when the virus can spread. 474 00:24:59,246 --> 00:25:03,499 The major time lag is not at the level of the laboratory. 475 00:25:03,501 --> 00:25:05,451 It's really in the field. 476 00:25:05,453 --> 00:25:09,654 It's recognizing the appearance of something as new. 477 00:25:09,656 --> 00:25:11,540 Then that has to percolate 478 00:25:11,542 --> 00:25:15,928 through the ether until it reaches people like us. 479 00:25:15,930 --> 00:25:18,330 Freeman: Ian's team could prevent 480 00:25:18,332 --> 00:25:20,599 millions if not billions of us 481 00:25:20,601 --> 00:25:23,886 from succumbing to a highly infectious disease. 482 00:25:23,888 --> 00:25:26,722 But if a virus evolves that is sufficiently different 483 00:25:26,724 --> 00:25:29,692 from the viruses we know today, 484 00:25:29,694 --> 00:25:32,778 Ian's team will not be able to fish it out. 485 00:25:32,780 --> 00:25:34,229 [ Beeping ] 486 00:25:34,231 --> 00:25:40,819 In humanity's war on viruses, we need a new strategy. 487 00:25:40,821 --> 00:25:43,288 We can hunt viruses down, 488 00:25:43,290 --> 00:25:48,410 and we can try to vaccinate ourselves against them. 489 00:25:48,412 --> 00:25:54,500 But once they infect us, we're at their mercy. 490 00:25:54,502 --> 00:25:58,721 What if we turn a virus into a zombie 491 00:25:58,723 --> 00:26:05,177 that works for us and make it kill a zombie virus? 492 00:26:06,058 --> 00:26:07,325 Modern medicine 493 00:26:07,327 --> 00:26:11,429 has conquered many diseases in the past century. 494 00:26:11,931 --> 00:26:16,334 Viruses, however, remain elusive targets. 495 00:26:16,336 --> 00:26:21,539 Because they hijack the vital genetic machinery of our cells, 496 00:26:21,541 --> 00:26:24,375 killing them is tricky. 497 00:26:24,377 --> 00:26:29,446 The solution may require a pair of these, 498 00:26:29,448 --> 00:26:34,085 shrunk down to the size of our D.N.A. 499 00:26:34,087 --> 00:26:35,887 [ Snip ] 500 00:26:35,889 --> 00:26:40,341 Viruses are party crashers. 501 00:26:40,343 --> 00:26:42,760 They do everything possible to blend in with healthy cells... 502 00:26:42,762 --> 00:26:44,512 Aah! [ Snarling ] 503 00:26:44,514 --> 00:26:46,297 Freeman: ...All the while 504 00:26:46,299 --> 00:26:49,300 relentlessly infecting the invited guests. 505 00:26:49,302 --> 00:26:51,102 For severe infections, 506 00:26:51,104 --> 00:26:54,605 our best medical treatments today are crude. 507 00:26:54,607 --> 00:26:59,410 They work by chopping up the harmful invaders... 508 00:26:59,412 --> 00:27:00,528 Party's over. 509 00:27:00,530 --> 00:27:02,146 [ Motor revs, women scream ] 510 00:27:02,148 --> 00:27:05,533 [ Saw buzzing ] ...And all the healthy cells 511 00:27:05,535 --> 00:27:06,867 in their vicinity. 512 00:27:06,869 --> 00:27:09,754 But a new treatment that only goes after the bad guys 513 00:27:09,756 --> 00:27:12,790 could be right around the corner. 514 00:27:14,159 --> 00:27:17,511 As the director of the Center for Nanomedicine 515 00:27:17,513 --> 00:27:19,130 at U.C. Santa Barbara, 516 00:27:19,132 --> 00:27:22,049 Jamey Marth thinks it should be possible 517 00:27:22,051 --> 00:27:24,051 to make an antiviral drug 518 00:27:24,053 --> 00:27:30,942 out of a class of chemicals that we all have in our stomachs. 519 00:27:30,944 --> 00:27:33,344 The food that I have on this plate right now 520 00:27:33,346 --> 00:27:37,481 is what I need to keep me alive and mostly healthy. 521 00:27:37,483 --> 00:27:39,650 [ Crunching ] 522 00:27:39,652 --> 00:27:42,353 But for my body to use this material, 523 00:27:42,355 --> 00:27:45,323 it has to convert it into different forms, 524 00:27:45,325 --> 00:27:51,028 and it does that by using small natural machines called enzymes. 525 00:27:51,030 --> 00:27:55,466 Freeman: Enzymes are the power tools of microbiology. 526 00:27:55,468 --> 00:28:00,671 In the stomach, they break apart our food into digestible forms. 527 00:28:00,673 --> 00:28:03,874 Jamey and his colleagues are working 528 00:28:03,876 --> 00:28:07,094 with an enzyme called C.R.E. Recombinase. 529 00:28:07,096 --> 00:28:10,881 This enzyme has remarkable utility. 530 00:28:10,883 --> 00:28:14,718 It can cut out any section of D.N.A. 531 00:28:14,720 --> 00:28:16,854 And neatly staple back together 532 00:28:16,856 --> 00:28:19,323 the two adjoining genetic pieces. 533 00:28:19,325 --> 00:28:21,275 It's allowed us to do things 534 00:28:21,277 --> 00:28:24,495 that we haven't been able to do before -- 535 00:28:24,497 --> 00:28:27,665 to remove specific genes from specific cells 536 00:28:27,667 --> 00:28:29,834 at different times. 537 00:28:32,204 --> 00:28:34,955 Freeman: Inside every cell in our body, 538 00:28:34,957 --> 00:28:37,625 there is a forest of D.N.A. 539 00:28:37,627 --> 00:28:40,344 Viruses sneak foreign genes 540 00:28:40,346 --> 00:28:44,248 into this forest and hijack our cellular machinery. 541 00:28:44,250 --> 00:28:49,253 A drug based on Jamey's C.R.E. Recombinase enzyme 542 00:28:49,255 --> 00:28:53,924 could chop down viral infections at their root 543 00:28:53,926 --> 00:28:56,644 by weeding out their D.N.A. 544 00:28:58,263 --> 00:29:01,265 The enzyme needs to find a specific sequence 545 00:29:01,267 --> 00:29:05,436 of 34 genetic letters at either end of the cut. 546 00:29:05,438 --> 00:29:08,489 And that sequence can be customized. 547 00:29:08,491 --> 00:29:12,443 So once you know the genetic sequence of a virus, 548 00:29:12,445 --> 00:29:14,628 you can program C.R.E. Recombinase 549 00:29:14,630 --> 00:29:19,884 to latch onto the first and last parts of this D.N.A. code. 550 00:29:19,886 --> 00:29:23,387 This represents viral D.N.A. -- 551 00:29:23,389 --> 00:29:25,139 D.N.A. that's foreign to the cell 552 00:29:25,141 --> 00:29:27,291 and has integrated itself into the genome. 553 00:29:27,293 --> 00:29:30,895 An enzyme like the C.R.E. Recombinase 554 00:29:30,897 --> 00:29:33,931 is capable of removing this precisely 555 00:29:33,933 --> 00:29:35,766 from the cell's genome. 556 00:29:35,768 --> 00:29:39,070 It does this with precision. 557 00:29:39,072 --> 00:29:40,104 [ Snip ] 558 00:29:40,106 --> 00:29:42,022 And then, what the enzyme will do 559 00:29:42,024 --> 00:29:43,908 is it will stitch back together 560 00:29:43,910 --> 00:29:46,527 the ends of the normal D.N.A. 561 00:29:46,529 --> 00:29:50,314 So that the cell is effectively cured... 562 00:29:50,316 --> 00:29:52,366 [ Stapler clicks ] 563 00:29:52,368 --> 00:29:54,452 ...of the disease. 564 00:29:54,454 --> 00:29:57,204 Freeman: Jamey is laying the groundwork 565 00:29:57,206 --> 00:30:02,126 for what could be a cure for all infectious viruses. 566 00:30:02,128 --> 00:30:04,211 H.I.V. A.I.D.S... 567 00:30:04,213 --> 00:30:05,662 [ Snip, click ] 568 00:30:05,664 --> 00:30:06,931 ...influenza... 569 00:30:06,933 --> 00:30:08,432 [ Snip, click ] 570 00:30:08,434 --> 00:30:10,184 ...even the common cold... 571 00:30:10,186 --> 00:30:11,835 [ Snip, click ] 572 00:30:11,837 --> 00:30:15,639 ...will all only exist in history books. 573 00:30:15,641 --> 00:30:19,193 And the delivery vehicle for this life-saving drug 574 00:30:19,195 --> 00:30:22,897 is the last thing you would expect -- 575 00:30:22,899 --> 00:30:24,565 another virus. 576 00:30:24,567 --> 00:30:30,070 We could reprogram that virus so that once that virus 577 00:30:30,072 --> 00:30:32,189 binds and goes inside the cell, 578 00:30:32,191 --> 00:30:35,126 instead of releasing a disease-causing payload, 579 00:30:35,128 --> 00:30:37,128 it will instead release a cargo 580 00:30:37,130 --> 00:30:40,664 that allows us to cure those cells. 581 00:30:40,666 --> 00:30:44,301 [ Screaming and crying ] 582 00:30:44,303 --> 00:30:45,536 Freeman: Our best weapon against a virus 583 00:30:45,538 --> 00:30:48,389 that turns humans into zombies 584 00:30:48,391 --> 00:30:52,593 could be a virus that we turn into our zombie slave. 585 00:30:52,595 --> 00:30:53,978 [ Roars ] 586 00:30:53,980 --> 00:30:55,479 Freeman: This harmful virus 587 00:30:55,481 --> 00:30:58,048 would be stripped of its disease payload 588 00:30:58,050 --> 00:31:00,684 and instead be filled 589 00:31:00,686 --> 00:31:04,888 with reprogrammed C.R.E. Recombinase enzymes, 590 00:31:04,890 --> 00:31:08,192 which can search throughout our entire bodies 591 00:31:08,194 --> 00:31:13,164 and only eliminate the unwanted invaders. 592 00:31:13,166 --> 00:31:14,865 [ Clinking ] 593 00:31:14,867 --> 00:31:17,535 But finding a universal cure for viruses may not save us 594 00:31:17,537 --> 00:31:20,204 from a world filled with zombies. 595 00:31:20,206 --> 00:31:24,175 A zombie takeover is already underway in a lab 596 00:31:24,177 --> 00:31:27,127 in North Carolina, where living creatures 597 00:31:27,129 --> 00:31:32,299 are turned into zombie drones at the press of a button. 598 00:31:34,319 --> 00:31:37,121 If I told you to run off a cliff, 599 00:31:37,423 --> 00:31:40,791 you wouldn't do it, would you? 600 00:31:40,793 --> 00:31:44,728 But what if I took control of the neurons in your brain 601 00:31:44,730 --> 00:31:48,832 and made your legs run straight off the edge? 602 00:31:48,834 --> 00:31:53,170 Turning a conscious person into a mindless zombie 603 00:31:53,172 --> 00:31:55,004 may only be a matter of finding 604 00:31:55,006 --> 00:31:57,307 and controlling the right circuits in the brain. 605 00:31:57,309 --> 00:31:59,008 [ Electricity crackling ] 606 00:31:59,010 --> 00:32:01,561 [ Chuckles ] 607 00:32:03,698 --> 00:32:08,852 How do you get a living mind to completely surrender its will? 608 00:32:11,789 --> 00:32:14,858 Electrical engineer Alper Bozkurt 609 00:32:14,860 --> 00:32:16,993 thinks we've been doing it for centuries 610 00:32:16,995 --> 00:32:19,796 by domesticating wild animals. 611 00:32:19,798 --> 00:32:22,699 The horses open themselves to our control 612 00:32:22,701 --> 00:32:27,003 thanks to this mutual beneficial relation that we have with them, 613 00:32:27,005 --> 00:32:30,373 and it took a long time for us to be able to train them, 614 00:32:30,375 --> 00:32:32,425 uh, basically to condition them 615 00:32:32,427 --> 00:32:34,761 with different rewards or punishments. 616 00:32:36,180 --> 00:32:39,382 Freeman: Alper looks at animals as electrical circuits. 617 00:32:39,384 --> 00:32:40,650 As a horse moves, 618 00:32:40,652 --> 00:32:41,885 its brain sends 619 00:32:41,887 --> 00:32:44,905 an elaborate series of commands to its muscles 620 00:32:44,907 --> 00:32:47,557 through the electrical wiring of its nerve cells. 621 00:32:47,559 --> 00:32:48,909 [ Electricity crackling ] 622 00:32:48,911 --> 00:32:51,862 But convincing a horse to make these complex movements 623 00:32:51,864 --> 00:32:54,965 only requires a simple input. 624 00:32:54,967 --> 00:32:58,118 So when the rider wants the horse to go to left, 625 00:32:58,120 --> 00:33:00,453 she just pulls the reins to left... 626 00:33:00,455 --> 00:33:01,671 [ Nickers ] 627 00:33:01,673 --> 00:33:04,791 ...and the horse starts going in that direction. 628 00:33:04,793 --> 00:33:06,543 And then, she wants it to go right. 629 00:33:06,545 --> 00:33:07,794 She just pulls it to right, 630 00:33:07,796 --> 00:33:09,796 and we see that horse is going on the right. 631 00:33:09,798 --> 00:33:11,298 [ Nickering ] 632 00:33:11,300 --> 00:33:13,300 And then she wants it to go forward. 633 00:33:13,302 --> 00:33:17,137 She just provides a gentle kick with her heels, 634 00:33:17,139 --> 00:33:19,356 and the horse knows that it needs to go forward, 635 00:33:19,358 --> 00:33:20,590 and it does it. 636 00:33:20,592 --> 00:33:23,092 [ Blusters ] 637 00:33:23,094 --> 00:33:26,696 Freeman: The horse obeys because of its training. 638 00:33:26,698 --> 00:33:28,431 But Alper thinks he can get 639 00:33:28,433 --> 00:33:30,483 the same results in other creatures 640 00:33:30,485 --> 00:33:33,653 without conditioning by replacing mechanical commands 641 00:33:33,655 --> 00:33:37,273 with electrical signals sent directly to the brain. 642 00:33:37,275 --> 00:33:39,826 I have a set of domino stones here 643 00:33:39,828 --> 00:33:43,279 representing a neural network like in any brain. 644 00:33:43,281 --> 00:33:46,583 A brain is a set of electrical relay networks. 645 00:33:46,585 --> 00:33:51,254 It is composed of excitable cells called neurons. 646 00:33:51,256 --> 00:33:54,424 Freeman: When neurons become electrically excited, 647 00:33:54,426 --> 00:33:57,126 they pass a signal on to their neighbors, 648 00:33:57,128 --> 00:33:59,563 which in turn pass the signal along. 649 00:33:59,565 --> 00:34:03,683 Alper only needs to stimulate one neuron, 650 00:34:03,685 --> 00:34:07,136 and the entire neural circuit will activate, 651 00:34:07,138 --> 00:34:11,491 resulting in a complex bodily action. 652 00:34:15,913 --> 00:34:18,782 It's a principle that should work in any brain, 653 00:34:18,784 --> 00:34:21,534 but Alper is starting with a simple mind -- 654 00:34:21,536 --> 00:34:24,371 the cockroach. 655 00:34:24,373 --> 00:34:27,657 Alper implanted electrodes into the sockets 656 00:34:27,659 --> 00:34:31,544 where a roach's antennae connect to its brain. 657 00:34:31,546 --> 00:34:33,129 [ Clicking ] 658 00:34:33,131 --> 00:34:35,932 When he sends an electronic pulse to the neurons inside, 659 00:34:35,934 --> 00:34:38,268 the roach becomes... 660 00:34:38,270 --> 00:34:42,338 a zombie. 661 00:34:42,340 --> 00:34:44,641 It goes wherever the electronic pulse 662 00:34:44,643 --> 00:34:50,647 tells it to go, and it even turns on a dime. 663 00:34:50,649 --> 00:34:54,017 So when we stimulate the right antenna of the insect, 664 00:34:54,019 --> 00:34:56,736 insect thinks there there's an obstacle in front of it, 665 00:34:56,738 --> 00:34:58,622 and it tries to make a left turn. 666 00:34:58,624 --> 00:35:01,291 And when we stimulate the left antenna, 667 00:35:01,293 --> 00:35:03,293 it tries to make a right turn. 668 00:35:08,582 --> 00:35:10,333 Freeman: Alper thinks his zombie bugs 669 00:35:10,335 --> 00:35:13,386 will one day save lives. 670 00:35:13,388 --> 00:35:17,373 He envisions cockroach cyborgs outfitted with cameras 671 00:35:17,375 --> 00:35:18,925 and G.P.S. chips 672 00:35:18,927 --> 00:35:23,763 so they can locate survivors under collapsed buildings. 673 00:35:23,765 --> 00:35:26,983 But his breakthrough could be the beginning of a world 674 00:35:26,985 --> 00:35:29,819 where no mind is safe. 675 00:35:29,821 --> 00:35:34,607 Theoretically, even a human could be zombified. 676 00:35:37,445 --> 00:35:39,112 We know how neurons work, 677 00:35:39,114 --> 00:35:41,731 and, uh, we can communicate with them. 678 00:35:41,733 --> 00:35:43,199 When we stimulate the insect, 679 00:35:43,201 --> 00:35:45,201 it is the same stimulation principle 680 00:35:45,203 --> 00:35:47,954 that is used in deep brain stimulation patients 681 00:35:47,956 --> 00:35:49,956 with Parkinson's disease. 682 00:35:49,958 --> 00:35:52,042 So these are all the same principles. 683 00:35:52,044 --> 00:35:56,046 It's relatively easy with cockroaches 684 00:35:56,048 --> 00:35:59,015 to make them follow our command signals. 685 00:35:59,017 --> 00:36:02,218 But with higher organisms, with vertebrates, 686 00:36:02,220 --> 00:36:05,772 it is much complicated, although it's not impossible. 687 00:36:05,774 --> 00:36:09,476 Freeman: Technology may soon exist that, in the wrong hands, 688 00:36:09,478 --> 00:36:12,812 could turn us into zombies. 689 00:36:12,814 --> 00:36:17,734 If our minds are taken over, will we even know it? 690 00:36:17,736 --> 00:36:21,654 A zombie apocalypse may already be happening today. 691 00:36:21,656 --> 00:36:25,158 In fact, this neuroscientist thinks 692 00:36:25,160 --> 00:36:27,610 we're already 98% zombie. 693 00:36:30,886 --> 00:36:32,153 In fiction, 694 00:36:32,155 --> 00:36:35,256 the nightmare of a zombie apocalypse 695 00:36:35,258 --> 00:36:39,177 is constantly taking on new forms, 696 00:36:39,179 --> 00:36:42,430 but they all have a common theme -- 697 00:36:42,432 --> 00:36:47,669 the infected don't even know they are zombies. 698 00:36:47,671 --> 00:36:52,156 If, right now, we were zombies in the midst of an apocalypse, 699 00:36:52,158 --> 00:36:54,409 would we even know it? 700 00:36:56,695 --> 00:36:59,647 [ Birds chirping ] 701 00:36:59,649 --> 00:37:01,499 Neuroscientist Scott Grafton 702 00:37:01,501 --> 00:37:03,985 believes that in sports like golf, 703 00:37:03,987 --> 00:37:08,006 it pays to be a zombie. 704 00:37:08,008 --> 00:37:09,290 I was watching this tournament 705 00:37:09,292 --> 00:37:12,010 where Fuzzy Zoeller was winning. 706 00:37:12,012 --> 00:37:13,094 [ Whack ] 707 00:37:13,096 --> 00:37:14,963 Announcer runs up to him and says, 708 00:37:14,965 --> 00:37:17,265 "Fuzzy, how did you do it? How did you win?" 709 00:37:17,267 --> 00:37:21,069 He says, "Well, I've been brain-dead all week." 710 00:37:21,071 --> 00:37:22,503 [ Whack ] 711 00:37:22,505 --> 00:37:27,341 Freeman: After enough practice, a good swing is automatic. 712 00:37:27,343 --> 00:37:31,362 In fact, nearly everything that our bodies do 713 00:37:31,364 --> 00:37:34,515 requires little, if any, thought. 714 00:37:34,517 --> 00:37:37,685 Almost all of our actions are actually unconscious. 715 00:37:37,687 --> 00:37:41,239 We can pretend we access our muscle. 716 00:37:41,241 --> 00:37:43,074 You know, when I hold a golf club, 717 00:37:43,076 --> 00:37:44,492 I can grip it, and then I can think, 718 00:37:44,494 --> 00:37:48,496 okay, flex this muscle, extend this muscle, 719 00:37:48,498 --> 00:37:52,867 turn my shoulders, turn my waist, so forth. 720 00:37:52,869 --> 00:37:58,806 But actually, I have very, very poor access to those muscles. 721 00:37:58,808 --> 00:38:03,311 It's much easier to visualize what you'd like to happen, 722 00:38:03,313 --> 00:38:06,064 and the swing just takes care of itself. 723 00:38:07,215 --> 00:38:09,150 [ Whack ] 724 00:38:09,152 --> 00:38:12,219 Freeman: Our brains are goal-oriented. 725 00:38:12,221 --> 00:38:14,221 We think of an end result, 726 00:38:14,223 --> 00:38:18,526 and our bodies mindlessly follow a program to achieve it. 727 00:38:18,528 --> 00:38:21,362 Freeman: For Scott, this is evidence 728 00:38:21,364 --> 00:38:24,916 that our willpower is not as strong as we think. 729 00:38:24,918 --> 00:38:29,337 On a good day, I think we're about, uh...97% zombie, 730 00:38:29,339 --> 00:38:35,126 and on a bad day, 98% zombie, and the rest of the 2 or 3% 731 00:38:35,128 --> 00:38:37,411 is us having actually willful control 732 00:38:37,413 --> 00:38:39,580 over our daily activities. 733 00:38:41,800 --> 00:38:43,417 Freeman: Scott is running an experiment 734 00:38:43,419 --> 00:38:49,107 to momentarily rob his subject, misty, of the other 2%. 735 00:38:50,726 --> 00:38:52,226 He uses a technique 736 00:38:52,228 --> 00:38:55,313 called transcranial magnetic stimulation, 737 00:38:55,315 --> 00:38:57,398 or T.M.S., to induce 738 00:38:57,400 --> 00:38:59,651 a harmless electrical current in her brain. 739 00:38:59,653 --> 00:39:01,069 [ Click ] Oh. 740 00:39:01,071 --> 00:39:04,706 T.M.S. is a method for 741 00:39:04,708 --> 00:39:08,493 very briefly turning off a small part of your brain, 742 00:39:08,495 --> 00:39:12,213 so it's a copper coil that goes against the skull, 743 00:39:12,215 --> 00:39:14,949 and you induce a current through that, 744 00:39:14,951 --> 00:39:16,334 and during that time, 745 00:39:16,336 --> 00:39:19,620 you essentially have a virtual lesion in your brain. 746 00:39:19,622 --> 00:39:20,622 [ Clicking ] 747 00:39:20,623 --> 00:39:22,456 Freeman: Scott calibrates the device 748 00:39:22,458 --> 00:39:26,427 by stimulating the neurons that control her right hand. 749 00:39:26,429 --> 00:39:31,966 He then moves the device to focus on her parietal cortex. 750 00:39:33,969 --> 00:39:36,821 This region of the brain is believed to be responsible 751 00:39:36,823 --> 00:39:41,075 for making sure that our actions match our intentions, 752 00:39:41,077 --> 00:39:45,079 like trying to touch an illuminated dot. 753 00:39:45,081 --> 00:39:47,749 In the first round of Scott's experiment, 754 00:39:47,751 --> 00:39:50,585 there is no T.M.S. pulse. 755 00:39:50,587 --> 00:39:52,453 As soon as their hand starts moving, 756 00:39:52,455 --> 00:39:56,708 we jump that second light to the right a few inches, 757 00:39:56,710 --> 00:40:01,929 and their hand quickly corrects for that jump, 758 00:40:01,931 --> 00:40:06,167 and it smoothly goes over and pursues that new location. 759 00:40:06,169 --> 00:40:07,969 Freeman: But in the second round, 760 00:40:07,971 --> 00:40:13,107 right as misty's finger moves, Scott zaps her parietal cortex. 761 00:40:13,109 --> 00:40:14,341 Oh. 762 00:40:14,343 --> 00:40:16,060 Freeman: She doesn't feel the pulse 763 00:40:16,062 --> 00:40:17,845 but loses the ability to consciously 764 00:40:17,847 --> 00:40:20,698 correct her action for a brief moment. 765 00:40:20,700 --> 00:40:22,483 They react, essentially, 766 00:40:22,485 --> 00:40:25,319 as a zombie and go to the original location, 767 00:40:25,321 --> 00:40:26,654 that second light, 768 00:40:26,656 --> 00:40:28,790 and they're unable to correct themselves on the fly. 769 00:40:28,792 --> 00:40:31,826 So when we turn off the parietal lobe, 770 00:40:31,828 --> 00:40:35,413 we're essentially making a person a full zombie 771 00:40:35,415 --> 00:40:37,832 for just a second or so. 772 00:40:37,834 --> 00:40:38,883 And during that time, 773 00:40:38,885 --> 00:40:40,034 they're just carrying out a movement 774 00:40:40,036 --> 00:40:41,969 that they no longer can control. 775 00:40:41,971 --> 00:40:45,590 Freeman: Scott believes we evolved to be 98% zombie 776 00:40:45,592 --> 00:40:48,843 so that the intellectual parts of our brains 777 00:40:48,845 --> 00:40:52,680 could be freed up from thinking about the menial tasks 778 00:40:52,682 --> 00:40:55,850 that take up most of our time. 779 00:40:55,852 --> 00:40:58,886 For all of its evolutionary advantages, 780 00:40:58,888 --> 00:41:03,024 the intelligent human brain may come with a cost. 781 00:41:03,026 --> 00:41:05,943 I think we're a hair's breadth away from a zombie apocalypse 782 00:41:05,945 --> 00:41:09,230 in the sense that most of what we do, 783 00:41:09,232 --> 00:41:10,865 we can accomplish without thinking about it. 784 00:41:10,867 --> 00:41:13,668 Just think about how many willful choices 785 00:41:13,670 --> 00:41:15,753 you've made in the last week. 786 00:41:15,755 --> 00:41:18,005 It's probably maybe one or two. 787 00:41:18,007 --> 00:41:21,709 Everything else you did was essentially automatic behavior. 788 00:41:21,711 --> 00:41:25,346 So now you think of something, it takes away that last 2%. 789 00:41:25,348 --> 00:41:29,217 You're already prepared to live as a zombie. 790 00:41:29,219 --> 00:41:32,053 Freeman: By the time we reach adulthood, 791 00:41:32,055 --> 00:41:34,972 most of our daily lives are spent engaging 792 00:41:34,974 --> 00:41:37,525 in activities that require little conscious thought. 793 00:41:37,527 --> 00:41:42,396 If we were to lose our ability to make conscious decisions, 794 00:41:42,398 --> 00:41:45,533 life just might continue as normal. 795 00:41:45,535 --> 00:41:48,486 Certainly, we wouldn't recognize it in ourselves, 796 00:41:48,488 --> 00:41:51,155 and the scary thing is whether you could recognize it 797 00:41:51,157 --> 00:41:52,907 in anyone else. 798 00:41:52,909 --> 00:41:55,409 If there was a zombie apocalypse, 799 00:41:55,411 --> 00:41:58,112 I don't think it would be like "World War Z." 800 00:41:58,114 --> 00:42:00,631 I think we would be plain old normal human beings, 801 00:42:00,633 --> 00:42:02,667 except we'd be a little bit different. 802 00:42:02,669 --> 00:42:05,286 We'd be more like "invasion of the body snatchers," 803 00:42:05,288 --> 00:42:09,857 where we're ourselves, but we're not ourselves anymore. 804 00:42:17,533 --> 00:42:21,686 We humans love our free will. 805 00:42:21,688 --> 00:42:23,938 As bizarre as it may seem, 806 00:42:23,940 --> 00:42:27,525 it is entirely possible that a microscopic parasite 807 00:42:27,527 --> 00:42:29,810 or technology run wild 808 00:42:29,812 --> 00:42:34,815 could take away the free will we cherish so dearly. 809 00:42:34,817 --> 00:42:37,168 All of this talk of zombie apocalypse 810 00:42:37,170 --> 00:42:40,454 raises one final question -- 811 00:42:40,456 --> 00:42:45,543 why do we enjoy scaring ourselves half to death? 812 00:42:45,545 --> 00:42:47,762 Maybe that's what we need to do 813 00:42:47,764 --> 00:42:50,965 in order to prepare for the worst. 814 00:42:50,967 --> 00:42:55,816 I'm not scared, because science is our best defense. 815 00:42:55,817 --> 00:43:01,817 == sync, corrected by elderman == @elder_man 64086

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