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These are the user uploaded subtitles that are being translated: 1 00:00:02,795 --> 00:00:04,829 Freeman: The end of life. 2 00:00:05,544 --> 00:00:11,333 It's a reality that terrifies us and motivates us. 3 00:00:11,334 --> 00:00:15,103 Now cutting-edge science embarks on a bold mission 4 00:00:15,105 --> 00:00:17,572 to extend human life. 5 00:00:17,574 --> 00:00:18,773 [ Engine revs ] 6 00:00:18,775 --> 00:00:21,442 Some think the answer lies in biology. 7 00:00:22,611 --> 00:00:26,581 Some believe it might be in our brains. 8 00:00:26,583 --> 00:00:28,950 And others claim that immortality would mean 9 00:00:28,952 --> 00:00:31,819 the end of humanity. 10 00:00:31,821 --> 00:00:36,157 Will death remain inevitable? 11 00:00:36,159 --> 00:00:38,660 Or can we live forever? 12 00:00:38,662 --> 00:00:39,861 [ Crying ] 13 00:00:43,532 --> 00:00:48,303 Freeman: Space, time, life itself. 14 00:00:50,406 --> 00:00:55,376 The secrets of the cosmos lie through the wormhole. 15 00:00:55,378 --> 00:00:59,378 ? Through the Wormhole 2x08 ? Can We Live Forever? Original Air Date on July 27, 2011 16 00:00:59,380 --> 00:01:03,380 == sync, corrected by elderman == 17 00:01:07,122 --> 00:01:11,025 The sands of time run swiftly, 18 00:01:11,027 --> 00:01:14,162 a reminder that life is fleeting; 19 00:01:14,164 --> 00:01:16,698 death is a humbling reality. 20 00:01:16,700 --> 00:01:21,569 But what if life had no end? 21 00:01:21,571 --> 00:01:24,706 In just the past 200 years, 22 00:01:24,708 --> 00:01:26,808 the average life-span has doubled 23 00:01:26,810 --> 00:01:30,078 from about 40 to almost 80 years. 24 00:01:30,080 --> 00:01:32,647 Breakthroughs in biology and physics 25 00:01:32,649 --> 00:01:36,117 could soon bring immortality within our grasp. 26 00:01:36,119 --> 00:01:40,121 For better or worse, many of you watching me right now 27 00:01:40,123 --> 00:01:41,589 may live to see the day 28 00:01:41,591 --> 00:01:47,395 when aging and death itself are relics of a distant past. 29 00:01:50,566 --> 00:01:53,935 I remember rummaging through my grandmother's trunk once, 30 00:01:53,937 --> 00:01:58,306 happening upon objects that had been stored away for years. 31 00:01:58,308 --> 00:02:04,612 Everything was faded, curled, rusted. 32 00:02:04,614 --> 00:02:06,481 I couldn't help but wonder, 33 00:02:06,483 --> 00:02:09,617 when would the same decay happen to me? 34 00:02:14,590 --> 00:02:16,624 Michio Kaku, 35 00:02:16,626 --> 00:02:19,660 a theoretical physicist at City College of New York, 36 00:02:19,662 --> 00:02:22,797 is fascinated with the big questions in science, 37 00:02:22,799 --> 00:02:25,133 like whether the laws of physics 38 00:02:25,135 --> 00:02:29,437 require that all living things die. 39 00:02:29,439 --> 00:02:31,272 One of the iron laws of physics 40 00:02:31,274 --> 00:02:33,574 is the second law of thermodynamics, 41 00:02:33,576 --> 00:02:35,009 which says that everything rusts, 42 00:02:35,011 --> 00:02:38,446 everything decays, falls apart. 43 00:02:38,448 --> 00:02:41,649 We're all made out of atoms, and these atoms, in turn, 44 00:02:41,651 --> 00:02:44,051 obey the second law of thermodynamics. 45 00:02:45,988 --> 00:02:49,223 Freeman: Anything and everything in the Universe 46 00:02:49,225 --> 00:02:53,561 has the tendency to go from order to disorder. 47 00:02:53,563 --> 00:02:56,164 And once the damage is done, 48 00:02:56,166 --> 00:03:01,536 it's extremely difficult to reverse things and un-mix them. 49 00:03:01,538 --> 00:03:04,372 It's a process known as entropy. 50 00:03:04,374 --> 00:03:06,741 If I mix coffee, 51 00:03:06,743 --> 00:03:12,747 I realize that when I put cream into coffee, I increase entropy. 52 00:03:12,749 --> 00:03:14,215 I increase disorder. 53 00:03:14,217 --> 00:03:18,953 In fact, to see this milk jump out and reform in this cup 54 00:03:18,955 --> 00:03:21,556 is such a preposterous event 55 00:03:21,558 --> 00:03:23,391 that you would have to wait longer 56 00:03:23,393 --> 00:03:26,994 than the lifetime of the Universe to see it happen. 57 00:03:26,996 --> 00:03:32,200 Freeman: The second law of thermodynamics is an unremitting force. 58 00:03:32,202 --> 00:03:36,971 Nothing is immune to the power of entropy, 59 00:03:36,973 --> 00:03:39,173 not even the cells in our body. 60 00:03:39,175 --> 00:03:41,309 Kaku: And that's why we age. 61 00:03:41,311 --> 00:03:44,645 In fact, that's why we die. 62 00:03:44,647 --> 00:03:49,550 But it turns out that there is a loophole to the law of entropy. 63 00:03:49,552 --> 00:03:54,422 There is a way to restore order from disorder. 64 00:03:54,424 --> 00:03:57,291 Kaku: Imagine that each one represents an atom. 65 00:03:57,293 --> 00:04:01,395 Now, if I apply the second law of thermodynamics, 66 00:04:01,397 --> 00:04:05,266 it means that entropy increases. It mixes. Chaos reigns. 67 00:04:05,268 --> 00:04:06,834 Watch this. 68 00:04:06,836 --> 00:04:11,205 Freeman: The candy on the tray starts off organized and color-coded. 69 00:04:11,207 --> 00:04:13,641 But if the tray begins to vibrate, 70 00:04:13,643 --> 00:04:16,010 the second law takes over. 71 00:04:16,012 --> 00:04:17,879 Kaku: Even though this is entropy in action, 72 00:04:17,881 --> 00:04:22,683 I can reverse entropy by adding energy from the outside. 73 00:04:23,619 --> 00:04:26,721 But the price is, I have to constantly be on alert, 74 00:04:26,723 --> 00:04:29,657 constantly add energy from the outside. 75 00:04:30,859 --> 00:04:34,161 I mean, this is hard work. 76 00:04:35,998 --> 00:04:38,199 Freeman: With energy and concentration, 77 00:04:38,201 --> 00:04:42,703 Michio can step in and stop the chaos. 78 00:04:42,705 --> 00:04:46,040 But reversing entropy in a tray of vibrating candy 79 00:04:46,042 --> 00:04:49,677 is far less complicated than reversing entropy in our bodies. 80 00:04:49,679 --> 00:04:52,513 Where would we even begin? 81 00:04:52,515 --> 00:04:53,714 [ Engine revving ] 82 00:04:56,919 --> 00:04:59,820 Valter Longo is searching for the answer. 83 00:04:59,822 --> 00:05:02,423 He is a Professor of Gerontology 84 00:05:02,425 --> 00:05:05,059 at the University of Southern California. 85 00:05:05,061 --> 00:05:10,665 He knows that many things live fast and die young, 86 00:05:10,667 --> 00:05:14,602 and he believes the road to reversing entropy in the body 87 00:05:14,604 --> 00:05:19,073 starts where things get the hottest -- in the engine. 88 00:05:19,075 --> 00:05:22,243 Longo: In the engine, the gasoline gets oxidized, 89 00:05:22,245 --> 00:05:23,744 and that's a combustion process, 90 00:05:23,746 --> 00:05:26,180 and this provides energy to the car. 91 00:05:26,182 --> 00:05:27,949 But because of the combustion, 92 00:05:27,951 --> 00:05:30,251 the engine itself can become damaged, 93 00:05:30,253 --> 00:05:33,020 and eventually, you have to rebuild the engine. 94 00:05:33,022 --> 00:05:35,856 Freeman: Every cell in our bodies 95 00:05:35,858 --> 00:05:41,462 have tiny engines called mitochondria. 96 00:05:41,464 --> 00:05:44,465 Mitochondria are double-membraned structures 97 00:05:44,467 --> 00:05:48,436 whose job is to provide energy. 98 00:05:48,438 --> 00:05:51,005 But when these powerhouses wear down, 99 00:05:51,007 --> 00:05:55,309 our body begins to decay and age. 100 00:05:55,311 --> 00:05:59,447 And so, you can imagine in the cells, instead, 101 00:05:59,449 --> 00:06:01,882 you have hundreds of these mitochondria, 102 00:06:01,884 --> 00:06:03,284 these little engines. 103 00:06:03,286 --> 00:06:06,387 And these hundreds of engines provide the energy locally 104 00:06:06,389 --> 00:06:08,656 to every single cell in our body. 105 00:06:08,658 --> 00:06:11,258 Freeman: But Valter has found a way 106 00:06:11,260 --> 00:06:13,961 to reverse this deterioration process 107 00:06:13,963 --> 00:06:18,666 and rejuvenate mitochondria in one tiny organism. 108 00:06:18,668 --> 00:06:21,535 He has extended the life of baker's yeast -- 109 00:06:21,537 --> 00:06:26,173 the kind you use to make bread and beer -- to 10 weeks. 110 00:06:26,175 --> 00:06:31,712 That's 10 times the yeast's normal life-span of 6 days. 111 00:06:31,714 --> 00:06:35,449 It may not sound like a long time, 112 00:06:35,451 --> 00:06:40,421 but it's equivalent to 800 human years. 113 00:06:40,423 --> 00:06:43,190 The yeast's longevity occurred 114 00:06:43,192 --> 00:06:48,529 when two genes, R.A.S.2 and S.C.H.9, 115 00:06:48,531 --> 00:06:50,731 were removed from its DNA. 116 00:06:50,733 --> 00:06:54,802 Longo: So these pathways that we've identified in yeast, 117 00:06:54,804 --> 00:06:59,240 in addition to promoting aging, they also promote DNA damage 118 00:06:59,242 --> 00:07:00,775 and the damage 119 00:07:00,777 --> 00:07:03,310 of a variety of different systems within the cells. 120 00:07:03,312 --> 00:07:06,147 Freeman: Valter wondered if this fountain of youth for yeast 121 00:07:06,149 --> 00:07:09,684 might apply to more complex life-forms. 122 00:07:09,686 --> 00:07:13,754 And so he began looking for the equivalent genes 123 00:07:13,756 --> 00:07:17,258 in a much larger organism -- 124 00:07:17,260 --> 00:07:19,226 mice. 125 00:07:19,228 --> 00:07:22,263 When he knocked out those two genes, 126 00:07:22,265 --> 00:07:26,133 these mice doubled their life expectancy. 127 00:07:26,135 --> 00:07:28,302 Longo: This is very encouraging 128 00:07:28,304 --> 00:07:30,871 because if you look at the similarities 129 00:07:30,873 --> 00:07:33,574 between a mouse and a human, 130 00:07:33,576 --> 00:07:36,777 we are over 90% identical in many ways. 131 00:07:36,779 --> 00:07:41,449 A mouse lives for 2 years, and people live for 100 years. 132 00:07:41,451 --> 00:07:42,783 So, you can see, 133 00:07:42,785 --> 00:07:45,720 with just a small modification of the genome, 134 00:07:45,722 --> 00:07:48,489 you can go from 2 years to 100 years. 135 00:07:48,491 --> 00:07:50,858 There's no law of physics 136 00:07:50,860 --> 00:07:54,228 that prevents us from finding the secret of longevity, 137 00:07:54,230 --> 00:07:57,865 the secret, perhaps, even of immortality. 138 00:07:57,867 --> 00:08:02,236 If you take, for example, the genome of millions of old people 139 00:08:02,238 --> 00:08:04,905 and the genome of millions of young people -- 140 00:08:04,907 --> 00:08:07,942 which we will do in the coming years -- and subtract, 141 00:08:07,944 --> 00:08:12,780 you will then find the genes where aging is concentrated. 142 00:08:12,782 --> 00:08:15,783 Already, we've identified over 60 genes 143 00:08:15,785 --> 00:08:17,952 involved in the aging process. 144 00:08:17,954 --> 00:08:19,453 Longo: Now, the question is, 145 00:08:19,455 --> 00:08:23,624 how do you reprogram a human that lives 100 years 146 00:08:23,626 --> 00:08:26,727 to be now a 2,000- or 3,000-year-old person? 147 00:08:26,729 --> 00:08:28,329 [ Engine revving ] 148 00:08:28,331 --> 00:08:31,232 Freeman: Valter's mission to keep our engines running forever 149 00:08:31,234 --> 00:08:35,402 has just begun, and he's in it for the long haul. 150 00:08:35,404 --> 00:08:37,104 Suppose we do find a way 151 00:08:37,106 --> 00:08:40,541 to keep our engines running for hundreds of years or more. 152 00:08:40,543 --> 00:08:45,012 We would all be very old for a very long time. 153 00:08:45,014 --> 00:08:46,981 But this scientist 154 00:08:46,983 --> 00:08:51,819 is digging for ways to keep us not just eternally alive... 155 00:08:51,821 --> 00:08:54,121 But eternally young. 156 00:08:58,184 --> 00:09:00,419 Take our current life-span 157 00:09:00,421 --> 00:09:05,024 and stretch it 5 or even 10 times longer. 158 00:09:05,026 --> 00:09:09,795 The joys of our youth would endure like an endless summer. 159 00:09:09,797 --> 00:09:14,933 But imagine suffering decade after decade with fragile bones, 160 00:09:14,935 --> 00:09:19,772 failing eyesight, and an ever-more-feeble mind. 161 00:09:19,774 --> 00:09:24,710 If we want to become immortal, we can't just extend life. 162 00:09:24,712 --> 00:09:30,749 We need to discover how to keep our bodies eternally youthful. 163 00:09:34,154 --> 00:09:39,425 Aubrey de Grey thinks of himself as a modern-day Methuselah. 164 00:09:39,427 --> 00:09:43,896 He has dedicated his career to fighting aging. 165 00:09:43,898 --> 00:09:47,232 Aubrey believes that many people who are born today 166 00:09:47,234 --> 00:09:49,735 could live to be 1,000 years old 167 00:09:49,737 --> 00:09:53,238 and remain physically young for most of that time. 168 00:09:53,240 --> 00:09:57,276 The key is a matter of good biological housekeeping -- 169 00:09:57,278 --> 00:10:00,346 taking the trash out of ourselves. 170 00:10:00,348 --> 00:10:02,014 So, what happens, indeed, 171 00:10:02,016 --> 00:10:05,017 is that certain types of material in the body 172 00:10:05,019 --> 00:10:07,152 just accumulate junk. 173 00:10:07,154 --> 00:10:11,557 Certain types of junk accumulate inside cells and between cells 174 00:10:11,559 --> 00:10:14,193 and stuff that we would not think of as junk, like DNA, 175 00:10:14,195 --> 00:10:18,597 accumulates randomness, which is a type of junk. 176 00:10:18,599 --> 00:10:20,632 Freeman: Cells have the important job 177 00:10:20,634 --> 00:10:23,001 of constantly breaking down waste, 178 00:10:23,003 --> 00:10:25,437 and they're mostly pretty good at it. 179 00:10:25,439 --> 00:10:26,572 But sometimes a cell 180 00:10:26,574 --> 00:10:29,274 comes across things that are so weird... 181 00:10:29,276 --> 00:10:32,711 None of this degradation machinery works on them. 182 00:10:32,713 --> 00:10:34,747 That's when the junk gets re-routed 183 00:10:34,749 --> 00:10:37,049 to what's called the lysosome, 184 00:10:37,051 --> 00:10:38,951 a vessel that houses 185 00:10:38,953 --> 00:10:42,421 the most powerful degradation machinery in the cell. 186 00:10:42,423 --> 00:10:45,023 And if the garbage can't be broken down, 187 00:10:45,025 --> 00:10:47,726 it stays there forever. 188 00:10:49,796 --> 00:10:53,399 Aubrey believes that the accumulation of garbage 189 00:10:53,401 --> 00:10:57,136 in the lysosomal storage unit is what causes aging. 190 00:10:57,138 --> 00:11:01,173 And he wants to free our bodies of these buildups. 191 00:11:01,175 --> 00:11:03,142 He realized the most logical way 192 00:11:03,144 --> 00:11:06,678 was to take a close look at waste itself. 193 00:11:06,680 --> 00:11:12,718 And he wondered, "In nature, what likes to eat junk?" 194 00:11:12,720 --> 00:11:14,853 Longo: We're working on an idea 195 00:11:14,855 --> 00:11:17,423 that we might be able to find other species, 196 00:11:17,425 --> 00:11:21,260 especially bacteria, that are able to break down 197 00:11:21,262 --> 00:11:24,730 the substances that accumulate in the human body. 198 00:11:24,732 --> 00:11:28,066 Freeman: Aubrey's hunt for the fountain of youth 199 00:11:28,068 --> 00:11:32,571 led him to a final resting place -- graveyards. 200 00:11:34,340 --> 00:11:36,008 Since graveyards are riddled 201 00:11:36,010 --> 00:11:39,011 with the waste of decomposing bodies, 202 00:11:39,013 --> 00:11:41,413 he suspected he might find microbes 203 00:11:41,415 --> 00:11:44,116 who live to feast on death. 204 00:11:44,118 --> 00:11:49,588 [De Grey] And if we can find the genes and enzymes that they are using 205 00:11:49,590 --> 00:11:51,590 to actually perform that function, 206 00:11:51,592 --> 00:11:54,726 then we might be able to put those genes and enzymes 207 00:11:54,728 --> 00:11:56,895 into our own cells 208 00:11:56,897 --> 00:11:58,897 so that our own cells can break stuff down 209 00:11:58,899 --> 00:12:00,833 that they could not naturally break down. 210 00:12:00,835 --> 00:12:04,336 Freeman: The secret to longevity might be 6 feet under. 211 00:12:04,338 --> 00:12:10,075 Aubrey and his team are still digging for the right microbe 212 00:12:10,077 --> 00:12:11,577 that will work in mammalian cells. 213 00:12:11,579 --> 00:12:13,445 And when they find it, 214 00:12:13,447 --> 00:12:19,351 he believes we will all live like 25-year-olds forever. 215 00:12:19,353 --> 00:12:23,155 [De Grey] I think that we have maybe a 50/50 chance 216 00:12:23,157 --> 00:12:25,858 in the next 25 years or so 217 00:12:25,860 --> 00:12:28,827 of developing what I think of as the first generation 218 00:12:28,829 --> 00:12:31,597 of bona fide rejuvenation biotechnology. 219 00:12:31,599 --> 00:12:32,898 In other words, 220 00:12:32,900 --> 00:12:35,534 technologies that are sufficiently comprehensive 221 00:12:35,536 --> 00:12:39,104 that we can give them to middle-aged people, 222 00:12:39,106 --> 00:12:42,941 people 60 or 70 or so, and fix them up well enough 223 00:12:42,943 --> 00:12:46,745 that they don't become biologically 60 or 70 again 224 00:12:46,747 --> 00:12:49,214 until 30 years later or something like that. 225 00:12:51,818 --> 00:12:55,621 Freeman: Aubrey is looking for the magic bullet that will fight aging, 226 00:12:55,623 --> 00:12:58,223 but synthetic biologist Chris Voigt 227 00:12:58,225 --> 00:13:01,493 is looking to build an entire army 228 00:13:01,495 --> 00:13:04,630 out of various parts from all over nature. 229 00:13:06,766 --> 00:13:10,402 Voigt: All right. Let's give this a shot. 230 00:13:14,741 --> 00:13:17,075 One of the things we're often trying to do 231 00:13:17,077 --> 00:13:19,444 in synthetic biology is create new functions 232 00:13:19,446 --> 00:13:23,048 out of parts that already exist in nature for other reason 233 00:13:23,050 --> 00:13:26,485 so we're often having to go out and grab those components 234 00:13:26,487 --> 00:13:29,388 from different organisms and put them together. 235 00:13:29,390 --> 00:13:32,357 Freeman: Chris searches for microorganisms 236 00:13:32,359 --> 00:13:36,194 throughout biology to find the right parts. 237 00:13:36,196 --> 00:13:38,664 And they end up at his lab 238 00:13:38,666 --> 00:13:41,800 at the University of California, San Francisco, 239 00:13:41,802 --> 00:13:45,103 where biology meets mechanics. 240 00:13:45,105 --> 00:13:47,940 Voigt: When you look at being able to fight disease, 241 00:13:47,942 --> 00:13:49,808 whether it's identifying malignant cells 242 00:13:49,810 --> 00:13:51,243 and killing them, 243 00:13:51,245 --> 00:13:53,512 we're trying to go through the garbage of all the functions 244 00:13:53,514 --> 00:13:55,013 that are out in the natural world 245 00:13:55,015 --> 00:13:58,550 and identify those that are useful to us 246 00:13:58,552 --> 00:14:00,686 in trying to be able to identify 247 00:14:00,688 --> 00:14:03,255 a correct disease state in the body. 248 00:14:03,257 --> 00:14:07,092 Freeman: To build a bio robot that can detect its surroundings, 249 00:14:07,094 --> 00:14:11,063 Chris and his team needed to find an organism with a sensor. 250 00:14:11,065 --> 00:14:15,300 And they found it... In pond scum... 251 00:14:15,302 --> 00:14:20,272 Where they discovered that algae are equipped with light sensors. 252 00:14:20,274 --> 00:14:23,508 Voigt: We took a bacterium that normally lives in your gut -- 253 00:14:23,510 --> 00:14:26,111 so it's not used to the Sun shining -- 254 00:14:26,113 --> 00:14:29,147 and we put in a light sensor out of an algae. 255 00:14:29,149 --> 00:14:32,951 Freeman: Inside Chris' bacterial darkroom, 256 00:14:32,953 --> 00:14:35,087 colonies of bacteria 257 00:14:35,089 --> 00:14:36,888 that are now implanted with algae light sensors 258 00:14:36,890 --> 00:14:40,258 are able to take photographs of slide-projected images. 259 00:14:42,495 --> 00:14:45,197 Freeman: It might look like bacterial art, 260 00:14:45,199 --> 00:14:47,332 but this is the first big step 261 00:14:47,334 --> 00:14:50,636 toward creating programmable biological robots 262 00:14:50,638 --> 00:14:53,305 that will keep our bodies healthy forever. 263 00:14:53,307 --> 00:14:56,842 Voigt: There are bacteria all throughout our bodies, 264 00:14:56,844 --> 00:14:59,945 and we can reprogram those bacteria 265 00:14:59,947 --> 00:15:03,148 in order to be able to implement therapeutic effects 266 00:15:03,150 --> 00:15:06,618 for just about any disease that you can imagine. 267 00:15:06,620 --> 00:15:10,555 The possibilities are limitless. 268 00:15:10,557 --> 00:15:13,258 Freeman: Chris' photographic bacteria 269 00:15:13,260 --> 00:15:15,494 are able to turn themselves on and off 270 00:15:15,496 --> 00:15:16,962 like the flip of a switch. 271 00:15:16,964 --> 00:15:18,530 But the question is, 272 00:15:18,532 --> 00:15:23,969 can Chris figure out how to program and control that switch? 273 00:15:23,971 --> 00:15:26,071 We'd like to see the programming of cells 274 00:15:26,073 --> 00:15:28,006 be the same as programming a computer 275 00:15:28,008 --> 00:15:29,541 or designing an electronic chip, 276 00:15:29,543 --> 00:15:32,210 where, as programmers, we would write out 277 00:15:32,212 --> 00:15:35,380 the exact function that we'd want the cells to do. 278 00:15:35,382 --> 00:15:38,283 And then that would be automatically compiled 279 00:15:38,285 --> 00:15:39,584 into a DNA sequence 280 00:15:39,586 --> 00:15:41,687 in the same way that a computer program 281 00:15:41,689 --> 00:15:45,123 gets compiled, ultimately, into ones and zeroes. 282 00:15:45,125 --> 00:15:46,458 That's the dream. 283 00:15:46,460 --> 00:15:48,994 [ Gulp! ] 284 00:15:48,996 --> 00:15:52,097 Freeman: Bio robots may one day roam our blood streams, 285 00:15:52,099 --> 00:15:56,635 police our organs, and respond to our internal 911 calls, 286 00:15:56,637 --> 00:16:00,672 keeping us free from the threat of disease. 287 00:16:02,341 --> 00:16:05,610 Chris Voigt's and Aubrey de Grey's research 288 00:16:05,612 --> 00:16:07,846 to keep our bodies healthy for eternity 289 00:16:07,848 --> 00:16:09,915 is still in the beginning stages. 290 00:16:09,917 --> 00:16:13,051 But what does this mean for us mere mortals 291 00:16:13,053 --> 00:16:15,620 who will never live to see the day 292 00:16:15,622 --> 00:16:18,056 when immortality is within reach? 293 00:16:18,058 --> 00:16:21,193 There is one chilling possibility 294 00:16:21,195 --> 00:16:27,699 that will give us all a chance to hang on, even after we die. 295 00:16:31,873 --> 00:16:34,675 We're all genetically programmed 296 00:16:34,677 --> 00:16:38,412 to lust for life and to flee from death. 297 00:16:38,414 --> 00:16:43,284 Eventually, we will discover the secret of immortality, 298 00:16:43,286 --> 00:16:45,586 but we're not there yet. 299 00:16:45,588 --> 00:16:50,691 To cheat death right now, we need to put aging on ice 300 00:16:50,693 --> 00:16:55,129 and be ready to grasp eternal life 301 00:16:55,131 --> 00:16:58,466 long after life abandons us. 302 00:17:01,636 --> 00:17:04,405 Greg Fahy is a cryobiologist. 303 00:17:04,407 --> 00:17:09,977 The goal of his team at biotech outfit 21st Century Medicine 304 00:17:09,979 --> 00:17:13,147 is to freeze human organs and tissues 305 00:17:13,149 --> 00:17:17,852 so that they can be revived, undamaged, centuries from now. 306 00:17:19,454 --> 00:17:22,022 Fahy: Cryopreservation is the preservation of living systems 307 00:17:22,024 --> 00:17:23,858 at very low temperatures. 308 00:17:23,860 --> 00:17:27,328 We usually are referring to temperatures that are low enough 309 00:17:27,330 --> 00:17:30,598 that you can store the system as long as you wish 310 00:17:30,600 --> 00:17:32,233 before you use it again. 311 00:17:32,235 --> 00:17:34,502 Cryopreservation is essential 312 00:17:34,504 --> 00:17:36,937 to get a cell or a tissue, an organ, 313 00:17:36,939 --> 00:17:39,940 from one place in time to another place in time 314 00:17:39,942 --> 00:17:43,844 without allowing that system to change in the process. 315 00:17:43,846 --> 00:17:46,113 Freeman: Scientists have been trying 316 00:17:46,115 --> 00:17:48,816 to preserve whole organs for decades. 317 00:17:48,818 --> 00:17:52,653 But it's a lot harder than throwing food in the freezer. 318 00:17:52,655 --> 00:17:58,526 When biological material freezes, ice crystals form, 319 00:17:58,528 --> 00:18:02,129 which push the cells out of their normal position. 320 00:18:02,131 --> 00:18:06,467 When you thaw the organ, it may look okay from the outside, 321 00:18:06,469 --> 00:18:10,871 but on the inside, it's damaged beyond repair. 322 00:18:12,941 --> 00:18:16,110 The biggest problem, we think, is really mechanical. 323 00:18:16,112 --> 00:18:18,679 It's the formation of ice between cells. 324 00:18:18,681 --> 00:18:21,849 If the cells are dislodged from their normal locations, 325 00:18:21,851 --> 00:18:23,083 then you can destroy 326 00:18:23,085 --> 00:18:25,753 the function of that structure as a whole 327 00:18:25,755 --> 00:18:27,421 even if the cells survive. 328 00:18:29,591 --> 00:18:32,626 Freeman: Greg and his team decided to focus their efforts 329 00:18:32,628 --> 00:18:34,528 on preventing bodily fluids from freezing 330 00:18:34,530 --> 00:18:36,630 and eventually developed a way 331 00:18:36,632 --> 00:18:41,502 to turn those fluids into a form of biological glass -- 332 00:18:41,504 --> 00:18:45,472 a technique he calls vitrification. 333 00:18:45,474 --> 00:18:48,709 Fahy: Vitrification is the formation of a glass. 334 00:18:48,711 --> 00:18:52,112 So if you take water and you mix it with various chemicals 335 00:18:52,114 --> 00:18:54,348 in high-enough concentrations of chemical 336 00:18:54,350 --> 00:18:56,850 and then cool it down to low temperatures, 337 00:18:56,852 --> 00:18:59,987 the system will never freeze no matter how low you go. 338 00:18:59,989 --> 00:19:01,455 Freeman: To test whether 339 00:19:01,457 --> 00:19:05,759 vitrification actually preserves the function of whole organs, 340 00:19:05,761 --> 00:19:09,897 Greg's team vitrified a rabbit kidney. 341 00:19:09,899 --> 00:19:13,233 Fahy: This is the kidney profusion lab. 342 00:19:13,235 --> 00:19:15,402 What John is doing in the background 343 00:19:15,404 --> 00:19:18,539 is delivering...through the vascular system of the kidney 344 00:19:18,541 --> 00:19:20,908 so the kidney becomes unfreezable. 345 00:19:20,910 --> 00:19:24,078 The kidney is sitting in a special chamber. 346 00:19:24,080 --> 00:19:25,546 The chamber is temperature-conditioned 347 00:19:25,548 --> 00:19:26,914 to minimize toxicity. 348 00:19:26,916 --> 00:19:28,749 And at the end of the process, 349 00:19:28,751 --> 00:19:30,851 the kidney's taken out and is transplanted. 350 00:19:30,853 --> 00:19:33,454 Freeman: This kidney, 351 00:19:33,456 --> 00:19:38,559 even though it has been stored at minus-22 degrees celsius, 352 00:19:38,561 --> 00:19:41,362 works just as well as a normal kidney. 353 00:19:41,364 --> 00:19:42,529 It's proof 354 00:19:42,531 --> 00:19:46,000 that Greg's vitrification technique actually works 355 00:19:46,002 --> 00:19:47,401 and might be the key 356 00:19:47,403 --> 00:19:52,539 to preserving human organs far into the future. 357 00:19:52,541 --> 00:19:56,410 So if you cool to below that glass-transition temperature, 358 00:19:56,412 --> 00:19:59,179 our calculations indicate you can store a system 359 00:19:59,181 --> 00:20:00,948 for tens of thousands of years. 360 00:20:00,950 --> 00:20:05,486 Freeman: Imagine being able to put your body on ice 361 00:20:05,488 --> 00:20:10,290 and then being revived 10,000 years from now. 362 00:20:10,292 --> 00:20:12,793 You could wake up and find yourself 363 00:20:12,795 --> 00:20:17,631 in an age when science has made immortality possible. 364 00:20:17,633 --> 00:20:20,000 Greg Fahy may be just a few years 365 00:20:20,002 --> 00:20:24,605 from giving a few select people a shot at eternal life. 366 00:20:24,607 --> 00:20:26,440 But that can only happen 367 00:20:26,442 --> 00:20:29,710 if cryopreservation works on an entire human body, 368 00:20:29,712 --> 00:20:33,080 not just simple organs like the kidney or the bladder, 369 00:20:33,082 --> 00:20:38,752 but on the most complex organ of all -- the brain. 370 00:20:38,754 --> 00:20:41,288 Fahy: This is the brain-slice vitrification lab. 371 00:20:41,290 --> 00:20:44,291 The setup shows a hippocampal slice -- 372 00:20:44,293 --> 00:20:47,728 the part of the brain that's associated with learning and memory -- 373 00:20:47,730 --> 00:20:50,597 in a little dish, essentially. 374 00:20:50,599 --> 00:20:53,600 On the right side, we have a stimulating electrode coming in, 375 00:20:53,602 --> 00:20:54,902 piercing the slice. 376 00:20:54,904 --> 00:20:57,938 On the left side, we have a recording electrode. 377 00:20:59,307 --> 00:21:03,077 Freeman: This brain slice has been vitrified. 378 00:21:03,079 --> 00:21:05,045 If it's still functional, 379 00:21:05,047 --> 00:21:08,515 when a pulse of electricity is fired into it, 380 00:21:08,517 --> 00:21:10,718 it should fire a signal back. 381 00:21:10,720 --> 00:21:14,488 To Greg and his team's surprise, it does. 382 00:21:14,490 --> 00:21:19,259 Electrical activity actually sparks up in this brain tissue. 383 00:21:19,261 --> 00:21:20,994 And the electrical response 384 00:21:20,996 --> 00:21:26,333 is every bit as strong as it was in its original state -- 385 00:21:26,335 --> 00:21:30,170 the recovery of the brain slice complete. 386 00:21:30,172 --> 00:21:33,407 Preserving a slice of the brain 387 00:21:33,409 --> 00:21:38,178 is a crucial first step toward preserving the whole thing. 388 00:21:38,180 --> 00:21:42,716 It's an ambitious project that Greg is already working on. 389 00:21:42,718 --> 00:21:47,354 We have found that it's fairly easy to vitrify the brain, 390 00:21:47,356 --> 00:21:51,158 that all of the structure seems to be preserved. 391 00:21:51,160 --> 00:21:53,260 But I have to say that so far, 392 00:21:53,262 --> 00:21:55,929 our techniques are not up to the level 393 00:21:55,931 --> 00:21:59,399 that we would like for that kind of speculative idea. 394 00:21:59,401 --> 00:22:02,035 But I couldn't say that you couldn't make up 395 00:22:02,037 --> 00:22:04,271 for whatever deficiencies 396 00:22:04,273 --> 00:22:07,141 that we have in our preservation technique today 397 00:22:07,143 --> 00:22:09,810 using some unknown future technology. 398 00:22:09,812 --> 00:22:12,412 I can't rule that out as a possibility. 399 00:22:16,017 --> 00:22:22,055 One day, centuries after we say goodbye to our loved ones, 400 00:22:22,057 --> 00:22:25,425 our frozen bodies could be reanimated, 401 00:22:25,427 --> 00:22:28,462 and we'll walk the earth again. 402 00:22:28,464 --> 00:22:31,598 But there could be a better route to immortality, 403 00:22:31,600 --> 00:22:33,267 one that would change 404 00:22:33,269 --> 00:22:36,937 the very nature of what it means to be human. 405 00:22:39,624 --> 00:22:42,459 Imagine if no one ever died. 406 00:22:42,461 --> 00:22:44,728 Where would we all live? 407 00:22:44,730 --> 00:22:47,497 Our planet is already crowded enough. 408 00:22:47,499 --> 00:22:50,434 But maybe there is a way to live forever 409 00:22:50,436 --> 00:22:54,204 without all this excess baggage. 410 00:22:54,206 --> 00:22:57,808 Poets say the essence of us is here, 411 00:22:57,810 --> 00:23:03,113 but I know what really makes me me is all up here. 412 00:23:03,115 --> 00:23:06,483 So if I want to endure for eternity, 413 00:23:06,485 --> 00:23:09,987 perhaps that's all I need to hang on to. 414 00:23:09,989 --> 00:23:14,324 What if we could find a way to upload our brains, 415 00:23:14,326 --> 00:23:17,928 to digitize the very essence of ourselves? 416 00:23:17,930 --> 00:23:22,566 Our minds could go on living long after our flesh has died. 417 00:23:22,568 --> 00:23:24,101 But to make that happen, 418 00:23:24,103 --> 00:23:27,037 we need to understand the brain's architecture 419 00:23:27,039 --> 00:23:31,108 and figure out what truly makes us who we are. 420 00:23:33,311 --> 00:23:38,482 Olaf Sporns is a neuroscientist at Indiana University. 421 00:23:38,484 --> 00:23:43,553 He is attempting to unscramble the brain's tangled web. 422 00:23:43,555 --> 00:23:45,188 Sporns: The brain is like a big city. 423 00:23:45,190 --> 00:23:48,125 Cities are examples of complex systems -- 424 00:23:48,127 --> 00:23:50,460 thousands of inhabitants and their social interactions, 425 00:23:50,462 --> 00:23:51,628 their flow of materials. 426 00:23:51,630 --> 00:23:54,931 The brain is like that -- millions of neurons, 427 00:23:54,933 --> 00:23:57,401 interactions between these neurons. 428 00:23:57,403 --> 00:24:00,704 In a sense, your brain is like a city of the mind. 429 00:24:00,706 --> 00:24:02,773 Freeman: The human brain 430 00:24:02,775 --> 00:24:06,310 is one of the most complex systems in the Universe. 431 00:24:06,312 --> 00:24:10,547 If you stretched out all of its electrical wiring, 432 00:24:10,549 --> 00:24:13,984 it would extend from the Earth to the Moon. 433 00:24:13,986 --> 00:24:17,487 Figuring out how we get from cells and wires 434 00:24:17,489 --> 00:24:19,990 to thoughts and memories 435 00:24:19,992 --> 00:24:24,494 is one of the greatest challenges known to science. 436 00:24:24,496 --> 00:24:26,797 Even though we've been studying the human brain, 437 00:24:26,799 --> 00:24:28,699 really, for decades, perhaps centuries, 438 00:24:28,701 --> 00:24:31,368 we still don't have a complete map of how it's connected. 439 00:24:31,370 --> 00:24:34,404 Freeman: But Olaf is taking on this challenge. 440 00:24:34,406 --> 00:24:39,209 His goal is to chart every single neuron and synapse 441 00:24:39,211 --> 00:24:43,447 and create a complete map of the brain, called the connectome. 442 00:24:43,449 --> 00:24:45,716 Sporns: It's a comprehensive set of connections 443 00:24:45,718 --> 00:24:47,651 that will allow us for the first time 444 00:24:47,653 --> 00:24:49,052 to understand in more detail 445 00:24:49,054 --> 00:24:51,388 how brain regions are connected to each other. 446 00:24:51,390 --> 00:24:53,924 Freeman: Olaf is creating the connectome 447 00:24:53,926 --> 00:24:58,028 using a leading-edge technique called diffusion imaging. 448 00:24:58,030 --> 00:25:00,864 It reveals the brain's long-distance connections 449 00:25:00,866 --> 00:25:04,067 by tracking water molecules along the neural highways. 450 00:25:04,069 --> 00:25:07,771 And what emerges is a detailed map 451 00:25:07,773 --> 00:25:11,208 of the central core of brain-cell connections. 452 00:25:11,210 --> 00:25:16,346 Olaf thinks this is the area where our personality resides. 453 00:25:16,348 --> 00:25:18,548 Sporns: As we've been discovering recently, 454 00:25:18,550 --> 00:25:21,051 some brain regions are more connected than others. 455 00:25:21,053 --> 00:25:23,053 Some are more essential, perhaps, 456 00:25:23,055 --> 00:25:25,021 for the functioning of the brain as a whole. 457 00:25:25,023 --> 00:25:28,325 Those regions, we call hubs. 458 00:25:28,327 --> 00:25:30,026 Freeman: If the brain is like a city... 459 00:25:30,028 --> 00:25:31,128 [ Tires screech ] 460 00:25:31,130 --> 00:25:33,397 ...Hubs are like major intersections 461 00:25:33,399 --> 00:25:36,099 where a constant flow of traffic passes through, 462 00:25:36,101 --> 00:25:38,568 getting people from one place to another. 463 00:25:38,570 --> 00:25:39,970 [ Bell clangs ] 464 00:25:39,972 --> 00:25:42,739 These intersections are so essential -- 465 00:25:42,741 --> 00:25:47,177 if they become disrupted in any way, the whole city shuts down. 466 00:25:47,179 --> 00:25:48,678 [ Sloop! ] 467 00:25:48,680 --> 00:25:53,016 By their nature, hubs are focal points of information traffic. 468 00:25:53,018 --> 00:25:55,452 Information converges on these regions, 469 00:25:55,454 --> 00:25:58,054 and it is that ebb and flow of information 470 00:25:58,056 --> 00:26:00,590 and the magnitude of the information flow 471 00:26:00,592 --> 00:26:02,492 that really sets these hubs apart 472 00:26:02,494 --> 00:26:04,327 from other regions of the brain. 473 00:26:04,329 --> 00:26:06,396 Freeman: Olaf is getting closer 474 00:26:06,398 --> 00:26:09,399 to figuring out where consciousness resides. 475 00:26:09,401 --> 00:26:12,302 Searching for the origins of consciousness 476 00:26:12,304 --> 00:26:15,005 is the holy grail of neuroscience. 477 00:26:15,007 --> 00:26:18,809 Only when this mystery is solved can we replicate the human brain 478 00:26:18,811 --> 00:26:21,611 and take consciousness from a person 479 00:26:21,613 --> 00:26:26,883 and transfer it to a machine as a way to live for eternity. 480 00:26:26,885 --> 00:26:31,087 And Olaf believes he has discovered a hub 481 00:26:31,089 --> 00:26:36,159 that might solve this mystery -- the medial parietal cortex. 482 00:26:36,161 --> 00:26:39,863 It's located between the brain's two hemispheres. 483 00:26:39,865 --> 00:26:45,368 Olaf suspects it might house the essence of who we are. 484 00:26:45,370 --> 00:26:48,538 Sporns: A lot of wires from the brain converge on that region. 485 00:26:48,540 --> 00:26:50,207 There are many lines of evidence 486 00:26:50,209 --> 00:26:52,375 that point to that part of the brain 487 00:26:52,377 --> 00:26:54,578 being really central and really important -- 488 00:26:54,580 --> 00:26:57,147 perhaps even for awareness and consciousness. 489 00:26:58,783 --> 00:27:00,050 Freeman: Olaf believes 490 00:27:00,052 --> 00:27:03,987 he may have solved the secrets of consciousness, 491 00:27:03,989 --> 00:27:08,124 but there is much more work to be done before he can be sure. 492 00:27:08,126 --> 00:27:11,495 Sporns: I think we're getting closer to answering this question. 493 00:27:11,497 --> 00:27:14,898 And as we identify which parts of the brain are critical 494 00:27:14,900 --> 00:27:17,901 in bringing about that particular functionality, 495 00:27:17,903 --> 00:27:20,270 that gets us closer to answering the question, 496 00:27:20,272 --> 00:27:21,605 "What is consciousness?" 497 00:27:21,607 --> 00:27:24,307 And also "Where are the critical components of the brain 498 00:27:24,309 --> 00:27:25,876 that contribute to it?" 499 00:27:25,878 --> 00:27:27,077 [ Electricity crackling ] 500 00:27:27,079 --> 00:27:29,713 Freeman: Neuroscience has taken enormous steps 501 00:27:29,715 --> 00:27:31,147 towards mapping the brain 502 00:27:31,149 --> 00:27:33,517 and solving the riddle of consciousness. 503 00:27:33,519 --> 00:27:36,186 But will we ever be able to capture 504 00:27:36,188 --> 00:27:39,589 the trillions of synapses, billions of neurons, 505 00:27:39,591 --> 00:27:43,827 and download ourselves onto a machine? 506 00:27:43,829 --> 00:27:46,730 Just imagine all the things that happen in the real world -- 507 00:27:46,732 --> 00:27:48,665 the conversation we are having now, 508 00:27:48,667 --> 00:27:50,867 me producing speech sounds and gestures, 509 00:27:50,869 --> 00:27:53,904 our brain's interacting in this embodied manner. 510 00:27:53,906 --> 00:27:56,273 That could not happen in a computer, 511 00:27:56,275 --> 00:27:57,407 and yet, it is somehow 512 00:27:57,409 --> 00:27:59,409 the essence of what life is all about. 513 00:27:59,411 --> 00:28:00,810 So I'm skeptical about that. 514 00:28:02,547 --> 00:28:06,850 Freeman: The brain might be far too complex to immortalize, 515 00:28:06,852 --> 00:28:11,555 but maybe there's a simpler path to eternal life -- 516 00:28:11,557 --> 00:28:13,023 not for you... 517 00:28:13,025 --> 00:28:18,028 But for immortal beings that we create from scratch. 518 00:28:21,245 --> 00:28:22,479 Life on this planet 519 00:28:22,481 --> 00:28:25,682 has had 4 billion years to evolve. 520 00:28:25,684 --> 00:28:30,120 We are the latest in a long line of species. 521 00:28:30,122 --> 00:28:32,522 We hope we're the last. 522 00:28:32,524 --> 00:28:37,694 But our quest for immortality could end in disaster 523 00:28:37,696 --> 00:28:42,999 because the first eternal beings may not be human. 524 00:28:43,001 --> 00:28:48,305 And they might just make us extinct. 525 00:28:51,242 --> 00:28:55,512 Complex life began from a few simple laws. 526 00:28:55,514 --> 00:29:00,217 The same might be true for artificial life. 527 00:29:00,219 --> 00:29:03,320 If humans discover those laws, there is a chance 528 00:29:03,322 --> 00:29:07,257 we could create living things that live forever. 529 00:29:07,259 --> 00:29:12,262 Oxford Physicist Vlatko Vedral is trying to understand 530 00:29:12,264 --> 00:29:15,765 how intelligence might emerge from a system 531 00:29:15,767 --> 00:29:19,503 that operates on just a few basic ground rules. 532 00:29:19,505 --> 00:29:21,638 Vedral: So, this is chess. 533 00:29:21,640 --> 00:29:23,440 It's a very complex game, 534 00:29:23,442 --> 00:29:27,477 and yet it's governed by a few very simple rules. 535 00:29:27,479 --> 00:29:31,114 You really have only 16 pieces on each side, 536 00:29:31,116 --> 00:29:33,583 and each piece can do one of two things. 537 00:29:33,585 --> 00:29:36,186 And you can say the same thing about life. 538 00:29:36,188 --> 00:29:37,787 Even though you are talking 539 00:29:37,789 --> 00:29:40,357 about one or two very simple rules, 540 00:29:40,359 --> 00:29:41,558 you still get this multitude 541 00:29:41,560 --> 00:29:44,294 of different possible behaviors in the Universe. 542 00:29:46,531 --> 00:29:50,534 Freeman: In 1970, a mathematician named John Conway 543 00:29:50,536 --> 00:29:52,369 ran with this idea 544 00:29:52,371 --> 00:29:55,205 and attempted to create artificial life-forms 545 00:29:55,207 --> 00:29:58,575 spontaneously using a computer program. 546 00:29:58,577 --> 00:30:01,011 He called it "The game of life." 547 00:30:01,013 --> 00:30:04,848 The game simulates the growth of artificial life, 548 00:30:04,850 --> 00:30:06,716 using a two-dimensional grid 549 00:30:06,718 --> 00:30:09,920 and simple cells that are either dead or alive. 550 00:30:09,922 --> 00:30:15,191 Whether the cells live or die is governed by a few basic rules. 551 00:30:15,193 --> 00:30:20,797 So, we have here in front of us a large cell block, 552 00:30:20,799 --> 00:30:24,467 and we can see this one central cell, which is on. 553 00:30:24,469 --> 00:30:29,906 And we can see that it has only one neighbor to its left. 554 00:30:29,908 --> 00:30:33,376 The cell just switches off, which means that it dies. 555 00:30:33,378 --> 00:30:35,045 And it dies of loneliness 556 00:30:35,047 --> 00:30:37,414 because it has too few neighbors. 557 00:30:37,416 --> 00:30:40,850 Well, now we've got a central cell, which is on, 558 00:30:40,852 --> 00:30:42,719 but it has five neighbors. 559 00:30:42,721 --> 00:30:45,722 It dies because of overcrowding, overpopulation. 560 00:30:45,724 --> 00:30:47,390 It doesn't like it, either. 561 00:30:47,392 --> 00:30:52,329 In the third example, a cell with only two neighbors -- 562 00:30:52,331 --> 00:30:54,297 the cell just keeps on living. 563 00:30:54,299 --> 00:30:57,267 It can even move around in this environment, 564 00:30:57,269 --> 00:30:58,735 and it can reproduce. 565 00:30:58,737 --> 00:31:02,238 So this is a good example where the population is just right 566 00:31:02,240 --> 00:31:04,808 for the cell to keep on living. 567 00:31:04,810 --> 00:31:08,144 Freeman: Given enough time, increasingly complex patterns 568 00:31:08,146 --> 00:31:11,014 emerge from this simple set of rules. 569 00:31:11,016 --> 00:31:15,418 Some even take on the appearance of living organisms. 570 00:31:15,420 --> 00:31:19,990 Vedral: John Conway tried to make the same point regarding life -- 571 00:31:19,992 --> 00:31:22,359 that it looks very complicated to us. 572 00:31:22,361 --> 00:31:24,661 And, indeed, it looks like a miracle 573 00:31:24,663 --> 00:31:26,396 that there is life around us, 574 00:31:26,398 --> 00:31:28,632 but, in fact, he constructed a game 575 00:31:28,634 --> 00:31:32,535 which consists of two or three, again, very simple rules, 576 00:31:32,537 --> 00:31:35,772 and it gives rise to some very complicated patterns. 577 00:31:35,774 --> 00:31:38,775 Freeman: How complex do these patterns need to be 578 00:31:38,777 --> 00:31:43,813 before they become something alive, intelligent, or immortal? 579 00:31:43,815 --> 00:31:47,617 Vlatko thinks the human brain is a good yardstick 580 00:31:47,619 --> 00:31:50,854 and has calculated its processing power. 581 00:31:50,856 --> 00:31:53,990 Vedral: The brain is currently still much more powerful 582 00:31:53,992 --> 00:31:55,625 than the existing computers. 583 00:31:55,627 --> 00:31:58,928 So the existing computers can do something like, you know, 584 00:31:58,930 --> 00:32:01,297 10 to the power of 12 beats per second, 585 00:32:01,299 --> 00:32:03,733 whereas our brain is still probably something 586 00:32:03,735 --> 00:32:06,136 like a million times faster than that. 587 00:32:06,138 --> 00:32:08,271 So you need 1 million laptops 588 00:32:08,273 --> 00:32:11,508 to simulate just a single human brain. 589 00:32:11,510 --> 00:32:14,844 Freeman: Today's computers are nowhere near powerful enough 590 00:32:14,846 --> 00:32:16,546 to house artificial intelligent life. 591 00:32:16,548 --> 00:32:19,149 Vlatko believes the answer might be to use 592 00:32:19,151 --> 00:32:21,317 a completely different type of computer -- 593 00:32:21,319 --> 00:32:23,853 the quantum computer. 594 00:32:23,855 --> 00:32:25,422 Quantum computer 595 00:32:25,424 --> 00:32:29,125 is basically the future technology of computation. 596 00:32:29,127 --> 00:32:32,662 It's a computer that's so fast, in principle, 597 00:32:32,664 --> 00:32:36,166 that no current computer can compete with it. 598 00:32:36,168 --> 00:32:38,635 Freeman: In place of transistors, 599 00:32:38,637 --> 00:32:41,971 quantum devices compute with individual atoms. 600 00:32:41,973 --> 00:32:45,375 And instead of sorting piles of ones and zeroes 601 00:32:45,377 --> 00:32:47,277 to give yes-and-no answers, 602 00:32:47,279 --> 00:32:49,345 the atoms in quantum computers 603 00:32:49,347 --> 00:32:52,682 can be ones, zeroes, and everything in between, 604 00:32:52,684 --> 00:32:56,886 existing as a computational maybe. 605 00:32:56,888 --> 00:32:59,355 The quantum computer really utilizes 606 00:32:59,357 --> 00:33:02,459 the quantum effect known as the super position, 607 00:33:02,461 --> 00:33:03,693 which means being 608 00:33:03,695 --> 00:33:06,496 in many different states at the same time. 609 00:33:06,498 --> 00:33:11,367 Freeman: This ability to handle a multiplicity of states 610 00:33:11,369 --> 00:33:13,369 allows quantum computers 611 00:33:13,371 --> 00:33:16,039 to juggle many overlapping problems at once, 612 00:33:16,041 --> 00:33:18,908 just the way our brains do. 613 00:33:20,211 --> 00:33:23,713 The analogy would be if I played a chord for you... 614 00:33:23,715 --> 00:33:26,416 [ Chord plays ] 615 00:33:26,418 --> 00:33:27,917 ...Then you would get 616 00:33:27,919 --> 00:33:31,521 many different modes played at the same time, 617 00:33:31,523 --> 00:33:33,089 which would really correspond 618 00:33:33,091 --> 00:33:36,126 to many states being out there simultaneously 619 00:33:36,128 --> 00:33:37,494 all in one location 620 00:33:37,496 --> 00:33:39,629 and the full power of quantum computation, 621 00:33:39,631 --> 00:33:41,798 which is actually unlimited, in some sense, 622 00:33:41,800 --> 00:33:42,999 if you start to store 623 00:33:43,001 --> 00:33:45,235 all the values in between the zero and the one. 624 00:33:45,237 --> 00:33:50,406 So then you really reach a stage where you can encode much more 625 00:33:50,408 --> 00:33:53,977 and the capacity really has no limits in that sense. 626 00:33:53,979 --> 00:33:55,445 Freeman: There might be a time 627 00:33:55,447 --> 00:33:58,848 when humans forego their own dream of immortality 628 00:33:58,850 --> 00:34:02,619 and create eternal artificial life. 629 00:34:02,621 --> 00:34:04,487 And if they do, 630 00:34:04,489 --> 00:34:07,524 how would artificial and biological life get along? 631 00:34:07,526 --> 00:34:10,660 Some people think that very soon 632 00:34:10,662 --> 00:34:14,164 computers will be smarter than us and they'll put us in zoos. 633 00:34:14,166 --> 00:34:17,834 They'll put us behind bars and throw peanuts at us 634 00:34:17,836 --> 00:34:19,969 and make us dance behind bars 635 00:34:19,971 --> 00:34:23,706 just like we make bears dance in zoos today. 636 00:34:23,708 --> 00:34:25,909 But at the present time, 637 00:34:25,911 --> 00:34:29,212 none of these technologies are ready for prime time. 638 00:34:29,214 --> 00:34:32,749 We simply don't have an operating quantum computer. 639 00:34:32,751 --> 00:34:37,587 The world's record for a quantum computer calculation is -- 640 00:34:37,589 --> 00:34:38,721 ta-da -- 641 00:34:38,723 --> 00:34:42,258 3 times 5 is 15. 642 00:34:42,260 --> 00:34:45,195 We sometimes forget that computers and robots, 643 00:34:45,197 --> 00:34:49,332 no matter how advanced they are, are adding machines. 644 00:34:49,334 --> 00:34:50,533 But that doesn't mean 645 00:34:50,535 --> 00:34:53,937 they have creativity, imagination, initiative. 646 00:34:53,939 --> 00:34:56,306 It doesn't mean they understand human values. 647 00:34:56,308 --> 00:34:59,442 It doesn't mean that they can make leaps of logic like we can. 648 00:34:59,444 --> 00:35:02,078 In other words, we have a long ways to go 649 00:35:02,080 --> 00:35:04,380 before we can begin to approximate 650 00:35:04,382 --> 00:35:08,017 the real thinking process that takes place in a human being. 651 00:35:08,019 --> 00:35:12,388 Freeman: We're safe from becoming slaves to quantum intelligence... 652 00:35:12,390 --> 00:35:13,923 For the time being. 653 00:35:13,925 --> 00:35:18,127 But this physicist envisions a different fate for mankind, 654 00:35:18,129 --> 00:35:22,565 one where the lines between artificial and biological life 655 00:35:22,567 --> 00:35:23,833 will blur 656 00:35:23,835 --> 00:35:27,403 and immortality will become reality, 657 00:35:27,405 --> 00:35:29,272 not just for the living... 658 00:35:29,274 --> 00:35:32,775 But also for the dead. 659 00:35:36,801 --> 00:35:38,768 We're taught to think of science and religion 660 00:35:38,770 --> 00:35:40,437 as separate truths. 661 00:35:40,439 --> 00:35:43,673 Albert Einstein didn't believe that. 662 00:35:43,675 --> 00:35:47,577 He said, "Science without religion is lame. 663 00:35:47,579 --> 00:35:50,847 Religion without science is blind." 664 00:35:50,849 --> 00:35:54,150 The secret to achieving immortality 665 00:35:54,152 --> 00:35:58,121 could require the fusion of humanity and God 666 00:35:58,123 --> 00:36:01,691 into an everlasting cosmic computer. 667 00:36:01,693 --> 00:36:05,695 Few people think further into the future than Frank Tipler, 668 00:36:05,697 --> 00:36:07,297 a mathematical physicist 669 00:36:07,299 --> 00:36:10,333 at Tulane university in New Orleans. 670 00:36:10,335 --> 00:36:13,803 Frank predicts that, at some point in our evolution, 671 00:36:13,805 --> 00:36:16,506 something truly remarkable will happen. 672 00:36:16,508 --> 00:36:22,779 Humanity, the Universe, and God will unite -- 673 00:36:22,781 --> 00:36:27,183 a moment he calls the omega point. 674 00:36:27,185 --> 00:36:31,955 Tipler: The omega point is the very end of the Universe. 675 00:36:31,957 --> 00:36:36,025 In the process, mankind, or, more precisely, our descendants, 676 00:36:36,027 --> 00:36:38,328 will expand out from this planet 677 00:36:38,330 --> 00:36:43,032 and ultimately engulf the entire Universe. 678 00:36:43,034 --> 00:36:47,303 As our descendants are moving into this final state, 679 00:36:47,305 --> 00:36:51,574 their knowledge and their power and their computer capacity 680 00:36:51,576 --> 00:36:55,245 is increasing without limit. 681 00:36:55,247 --> 00:36:56,646 The laws of physics 682 00:36:56,648 --> 00:36:59,682 allow a process that will convert matter -- 683 00:36:59,684 --> 00:37:05,555 stones of this graveyard, for instance -- into pure energy. 684 00:37:05,557 --> 00:37:08,324 That will be the ultimate energy source, 685 00:37:08,326 --> 00:37:11,861 which our descendants will use and gain control of it. 686 00:37:11,863 --> 00:37:14,964 Freeman: At the omega point, Frank argues, 687 00:37:14,966 --> 00:37:19,102 our descendants will be capable of doing anything. 688 00:37:19,104 --> 00:37:23,740 And with infinite power, they will create a cosmic computer 689 00:37:23,742 --> 00:37:25,642 and reconstruct in a simulation 690 00:37:25,644 --> 00:37:27,877 everything that has ever happened 691 00:37:27,879 --> 00:37:30,113 in the history of the Universe. 692 00:37:30,115 --> 00:37:33,950 Now, from the point of view of the beings in the far future, 693 00:37:33,952 --> 00:37:37,987 we will be their alternate ancestor as rational beings 694 00:37:37,989 --> 00:37:42,025 so they will be interested in what we were, what we were like. 695 00:37:42,027 --> 00:37:45,495 As a consequence, every man, woman, and child 696 00:37:45,497 --> 00:37:47,697 will be brought back into existence. 697 00:37:47,699 --> 00:37:50,900 It will be just like you are brought back with your body 698 00:37:50,902 --> 00:37:54,871 into a reconstructed earth just like we now live on. 699 00:37:54,873 --> 00:37:58,308 It will be different in one crucial respect. 700 00:37:58,310 --> 00:37:59,742 We will be resurrected, 701 00:37:59,744 --> 00:38:02,745 but we will never have to go through death again. 702 00:38:02,747 --> 00:38:05,348 Freeman: Frank claims the laws of physics 703 00:38:05,350 --> 00:38:08,651 not only permit this type of immortality -- 704 00:38:08,653 --> 00:38:11,421 they actually require it to happen. 705 00:38:11,423 --> 00:38:14,023 Tipler: Second law of thermodynamics says 706 00:38:14,025 --> 00:38:18,761 the complexity of the Universe at the most fundamental level 707 00:38:18,763 --> 00:38:21,030 is increasing without limit. 708 00:38:21,032 --> 00:38:22,932 I conclude 709 00:38:22,934 --> 00:38:25,869 that the validity of the second law of thermodynamics, 710 00:38:25,871 --> 00:38:28,471 throughout all of time, 711 00:38:28,473 --> 00:38:30,874 actually requires life 712 00:38:30,876 --> 00:38:35,311 to come into existence to gain control of the Universe. 713 00:38:35,313 --> 00:38:39,015 Freeman: Whether immortality comes in billions of years 714 00:38:39,017 --> 00:38:41,517 or whether it comes this century, 715 00:38:41,519 --> 00:38:46,022 the conquest of death will transform our civilization -- 716 00:38:46,024 --> 00:38:50,693 the way we live, the way we work, the way we love. 717 00:38:50,695 --> 00:38:53,997 Maybe the question is not "Can we live forever?" 718 00:38:53,999 --> 00:38:56,266 But "Should we?" 719 00:38:59,937 --> 00:39:01,537 Alexander Rose 720 00:39:01,539 --> 00:39:04,974 is the executive director of the Long Now Foundation, 721 00:39:04,976 --> 00:39:07,844 an organization whose main focus 722 00:39:07,846 --> 00:39:11,948 is the building of an unusual timepiece. 723 00:39:11,950 --> 00:39:16,419 It's called the clock of the long now, 724 00:39:16,421 --> 00:39:21,524 and it's designed to tick for 10,000 years. 725 00:39:21,526 --> 00:39:24,494 Rose: We built the 10,000-year clock 726 00:39:24,496 --> 00:39:27,597 to give people a different perspective 727 00:39:27,599 --> 00:39:29,499 of the really long term. 728 00:39:29,501 --> 00:39:31,901 If you believe that medical science or other things 729 00:39:31,903 --> 00:39:33,803 are going to increase human longevity, 730 00:39:33,805 --> 00:39:36,839 then the way that you would approach the world 731 00:39:36,841 --> 00:39:38,608 would be very, very differently -- 732 00:39:38,610 --> 00:39:41,477 just the same way that if we're designing a 10,000-year clock 733 00:39:41,479 --> 00:39:44,681 instead of a clock that just has to last for 10 years, 734 00:39:44,683 --> 00:39:47,750 we have approached this design problem very differently. 735 00:39:47,752 --> 00:39:50,887 And we have to be responsible over those next 10,000 years 736 00:39:50,889 --> 00:39:51,921 for our clock. 737 00:39:51,923 --> 00:39:54,090 Freeman: 10,000 years in the past, 738 00:39:54,092 --> 00:39:57,193 we were still living in the Stone Age. 739 00:39:57,195 --> 00:39:59,262 Flash forward the same period, 740 00:39:59,264 --> 00:40:01,898 and our civilization and technology 741 00:40:01,900 --> 00:40:04,701 will be unrecognizable. 742 00:40:04,703 --> 00:40:07,103 We realize in designing a 10,000-year clock 743 00:40:07,105 --> 00:40:10,974 that the most durable design is likely the simplest. 744 00:40:10,976 --> 00:40:15,211 Freeman: The clock of the long now will be all mechanical. 745 00:40:15,213 --> 00:40:18,314 Power in the clock will come from the force of gravity. 746 00:40:18,316 --> 00:40:23,386 A weight-driven system will turn a threaded bar. 747 00:40:23,388 --> 00:40:25,288 And the clock will keep time 748 00:40:25,290 --> 00:40:28,091 in both the short term, with the pendulum, 749 00:40:28,093 --> 00:40:30,827 and in the long term, through a solar synchronizer. 750 00:40:30,829 --> 00:40:35,331 This device may or may not last for 10 millennia, 751 00:40:35,333 --> 00:40:38,935 but that's not really Alexander's point. 752 00:40:38,937 --> 00:40:42,338 He wants to make us imagine what we will be like 753 00:40:42,340 --> 00:40:45,675 10,000 years from now. 754 00:40:45,677 --> 00:40:47,777 Rose: As soon as you see that 10,000-year clock 755 00:40:47,779 --> 00:40:50,313 and you visit it, the conversations that you have 756 00:40:50,315 --> 00:40:52,215 around whether or not humans will be there, 757 00:40:52,217 --> 00:40:54,684 the shapes of the hands of the people that might wind it -- 758 00:40:54,686 --> 00:40:56,352 "Are they gonna be the same as ours?" 759 00:40:56,354 --> 00:40:57,653 "Are they gonna be different?" 760 00:40:57,655 --> 00:41:00,423 Those kind of conversations immediately allow you 761 00:41:00,425 --> 00:41:03,292 to take responsibility for that kind of time span, 762 00:41:03,294 --> 00:41:05,495 and that's the hope with this clock. 763 00:41:05,497 --> 00:41:10,633 Freeman: 10,000 years from now, human beings may be immortal. 764 00:41:10,635 --> 00:41:12,068 Even if they're not, 765 00:41:12,070 --> 00:41:15,738 their life-spans will surely be vastly longer than ours. 766 00:41:15,740 --> 00:41:18,975 But it won't be just our bodies that will change. 767 00:41:18,977 --> 00:41:23,513 What it means to be human will be different. 768 00:41:23,515 --> 00:41:26,049 If you think about all the human values, 769 00:41:26,051 --> 00:41:27,550 quite a lot of them come 770 00:41:27,552 --> 00:41:30,453 from the fact that we know that life is finite. 771 00:41:30,455 --> 00:41:34,457 If you think, "How do I feel towards that person?" 772 00:41:34,459 --> 00:41:35,958 The fact that you know 773 00:41:35,960 --> 00:41:38,961 that the person is not gonna be there one day 774 00:41:38,963 --> 00:41:42,498 probably makes your emotions far stronger in some sense 775 00:41:42,500 --> 00:41:44,434 than other ways they would be. 776 00:41:44,436 --> 00:41:47,603 So this could all change, and maybe some of these things 777 00:41:47,605 --> 00:41:50,506 would even disappear from the human race 778 00:41:50,508 --> 00:41:52,909 if we simply knew we could live forever. 779 00:41:52,911 --> 00:41:55,878 Rose: What happens to marriage and relationships 780 00:41:55,880 --> 00:41:58,748 if our life-spans grow to 1,000 years or more? 781 00:41:58,750 --> 00:42:00,083 Right now, 782 00:42:00,085 --> 00:42:02,785 half of us get divorced just in our short lifetimes. 783 00:42:02,787 --> 00:42:04,787 But if we lived for 1,000 years, 784 00:42:04,789 --> 00:42:08,091 who knows how many times you might get married? 785 00:42:08,093 --> 00:42:10,660 I don't think that I would be able to live forever. 786 00:42:10,662 --> 00:42:12,595 I think my wife would kill me first. 787 00:42:12,597 --> 00:42:15,131 Freeman: Whether we like it or not, 788 00:42:15,133 --> 00:42:18,067 more and more scientists believe we will one day live 789 00:42:18,069 --> 00:42:22,338 in a world without age, disease, and death... 790 00:42:22,340 --> 00:42:26,476 That we'll revel in the joys and wonders of endless life 791 00:42:26,478 --> 00:42:30,480 and that we'll just have to learn to cope 792 00:42:30,482 --> 00:42:34,951 with the consequences of living forever. 793 00:42:34,953 --> 00:42:40,690 Mythology says that the Gods envy our mortality. 794 00:42:40,692 --> 00:42:42,325 Our mortality 795 00:42:42,327 --> 00:42:46,262 is what makes life precious and something to be savored. 796 00:42:46,264 --> 00:42:49,365 Driven by the pressure of time to achieve greatness, 797 00:42:49,367 --> 00:42:53,603 it may be our mortality that gives us our humanity. 798 00:42:53,605 --> 00:42:56,005 But as long as we are mortal, 799 00:42:56,007 --> 00:42:59,976 we'll never stop dreaming of life everlasting. 800 00:42:59,978 --> 00:43:04,180 That, too, is what makes us human. 801 00:43:04,254 --> 00:43:08,254 == sync, corrected by elderman ==65655

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