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These are the user uploaded subtitles that are being translated: 1 00:00:02,794 --> 00:00:04,828 Freeman: The end of life. 2 00:00:05,543 --> 00:00:11,332 It's a reality that terrifies us and motivates us. 3 00:00:11,333 --> 00:00:15,102 Now cutting-edge science embarks on a bold mission 4 00:00:15,104 --> 00:00:17,571 to extend human life. 5 00:00:17,573 --> 00:00:18,772 [ Engine revs ] 6 00:00:18,774 --> 00:00:21,441 Some think the answer lies in biology. 7 00:00:22,610 --> 00:00:26,580 Some believe it might be in our brains. 8 00:00:26,582 --> 00:00:28,949 And others claim that immortality would mean 9 00:00:28,951 --> 00:00:31,818 the end of humanity. 10 00:00:31,820 --> 00:00:36,156 Will death remain inevitable? 11 00:00:36,158 --> 00:00:38,659 Or can we live forever? 12 00:00:38,661 --> 00:00:39,860 [ Crying ] 13 00:00:43,531 --> 00:00:48,302 Freeman: Space, time, life itself. 14 00:00:50,405 --> 00:00:55,375 The secrets of the cosmos lie through the wormhole. 15 00:00:55,377 --> 00:00:59,377 ? Through the Wormhole 2x08 ? Can We Live Forever? Original Air Date on July 27, 2011 16 00:00:59,379 --> 00:01:03,379 == sync, corrected by elderman == 17 00:01:07,121 --> 00:01:11,024 The sands of time run swiftly, 18 00:01:11,026 --> 00:01:14,161 a reminder that life is fleeting; 19 00:01:14,163 --> 00:01:16,697 death is a humbling reality. 20 00:01:16,699 --> 00:01:21,568 But what if life had no end? 21 00:01:21,570 --> 00:01:24,705 In just the past 200 years, 22 00:01:24,707 --> 00:01:26,807 the average life-span has doubled 23 00:01:26,809 --> 00:01:30,077 from about 40 to almost 80 years. 24 00:01:30,079 --> 00:01:32,646 Breakthroughs in biology and physics 25 00:01:32,648 --> 00:01:36,116 could soon bring immortality within our grasp. 26 00:01:36,118 --> 00:01:40,120 For better or worse, many of you watching me right now 27 00:01:40,122 --> 00:01:41,588 may live to see the day 28 00:01:41,590 --> 00:01:47,394 when aging and death itself are relics of a distant past. 29 00:01:50,565 --> 00:01:53,934 I remember rummaging through my grandmother's trunk once, 30 00:01:53,936 --> 00:01:58,305 happening upon objects that had been stored away for years. 31 00:01:58,307 --> 00:02:04,611 Everything was faded, curled, rusted. 32 00:02:04,613 --> 00:02:06,480 I couldn't help but wonder, 33 00:02:06,482 --> 00:02:09,616 when would the same decay happen to me? 34 00:02:14,589 --> 00:02:16,623 Michio Kaku, 35 00:02:16,625 --> 00:02:19,659 a theoretical physicist at City College of New York, 36 00:02:19,661 --> 00:02:22,796 is fascinated with the big questions in science, 37 00:02:22,798 --> 00:02:25,132 like whether the laws of physics 38 00:02:25,134 --> 00:02:29,436 require that all living things die. 39 00:02:29,438 --> 00:02:31,271 One of the iron laws of physics 40 00:02:31,273 --> 00:02:33,573 is the second law of thermodynamics, 41 00:02:33,575 --> 00:02:35,008 which says that everything rusts, 42 00:02:35,010 --> 00:02:38,445 everything decays, falls apart. 43 00:02:38,447 --> 00:02:41,648 We're all made out of atoms, and these atoms, in turn, 44 00:02:41,650 --> 00:02:44,050 obey the second law of thermodynamics. 45 00:02:45,987 --> 00:02:49,222 Freeman: Anything and everything in the Universe 46 00:02:49,224 --> 00:02:53,560 has the tendency to go from order to disorder. 47 00:02:53,562 --> 00:02:56,163 And once the damage is done, 48 00:02:56,165 --> 00:03:01,535 it's extremely difficult to reverse things and un-mix them. 49 00:03:01,537 --> 00:03:04,371 It's a process known as entropy. 50 00:03:04,373 --> 00:03:06,740 If I mix coffee, 51 00:03:06,742 --> 00:03:12,746 I realize that when I put cream into coffee, I increase entropy. 52 00:03:12,748 --> 00:03:14,214 I increase disorder. 53 00:03:14,216 --> 00:03:18,952 In fact, to see this milk jump out and reform in this cup 54 00:03:18,954 --> 00:03:21,555 is such a preposterous event 55 00:03:21,557 --> 00:03:23,390 that you would have to wait longer 56 00:03:23,392 --> 00:03:26,993 than the lifetime of the Universe to see it happen. 57 00:03:26,995 --> 00:03:32,199 Freeman: The second law of thermodynamics is an unremitting force. 58 00:03:32,201 --> 00:03:36,970 Nothing is immune to the power of entropy, 59 00:03:36,972 --> 00:03:39,172 not even the cells in our body. 60 00:03:39,174 --> 00:03:41,308 Kaku: And that's why we age. 61 00:03:41,310 --> 00:03:44,644 In fact, that's why we die. 62 00:03:44,646 --> 00:03:49,549 But it turns out that there is a loophole to the law of entropy. 63 00:03:49,551 --> 00:03:54,421 There is a way to restore order from disorder. 64 00:03:54,423 --> 00:03:57,290 Kaku: Imagine that each one represents an atom. 65 00:03:57,292 --> 00:04:01,394 Now, if I apply the second law of thermodynamics, 66 00:04:01,396 --> 00:04:05,265 it means that entropy increases. It mixes. Chaos reigns. 67 00:04:05,267 --> 00:04:06,833 Watch this. 68 00:04:06,835 --> 00:04:11,204 Freeman: The candy on the tray starts off organized and color-coded. 69 00:04:11,206 --> 00:04:13,640 But if the tray begins to vibrate, 70 00:04:13,642 --> 00:04:16,009 the second law takes over. 71 00:04:16,011 --> 00:04:17,878 Kaku: Even though this is entropy in action, 72 00:04:17,880 --> 00:04:22,682 I can reverse entropy by adding energy from the outside. 73 00:04:23,618 --> 00:04:26,720 But the price is, I have to constantly be on alert, 74 00:04:26,722 --> 00:04:29,656 constantly add energy from the outside. 75 00:04:30,858 --> 00:04:34,160 I mean, this is hard work. 76 00:04:35,997 --> 00:04:38,198 Freeman: With energy and concentration, 77 00:04:38,200 --> 00:04:42,702 Michio can step in and stop the chaos. 78 00:04:42,704 --> 00:04:46,039 But reversing entropy in a tray of vibrating candy 79 00:04:46,041 --> 00:04:49,676 is far less complicated than reversing entropy in our bodies. 80 00:04:49,678 --> 00:04:52,512 Where would we even begin? 81 00:04:52,514 --> 00:04:53,713 [ Engine revving ] 82 00:04:56,918 --> 00:04:59,819 Valter Longo is searching for the answer. 83 00:04:59,821 --> 00:05:02,422 He is a Professor of Gerontology 84 00:05:02,424 --> 00:05:05,058 at the University of Southern California. 85 00:05:05,060 --> 00:05:10,664 He knows that many things live fast and die young, 86 00:05:10,666 --> 00:05:14,601 and he believes the road to reversing entropy in the body 87 00:05:14,603 --> 00:05:19,072 starts where things get the hottest -- in the engine. 88 00:05:19,074 --> 00:05:22,242 Longo: In the engine, the gasoline gets oxidized, 89 00:05:22,244 --> 00:05:23,743 and that's a combustion process, 90 00:05:23,745 --> 00:05:26,179 and this provides energy to the car. 91 00:05:26,181 --> 00:05:27,948 But because of the combustion, 92 00:05:27,950 --> 00:05:30,250 the engine itself can become damaged, 93 00:05:30,252 --> 00:05:33,019 and eventually, you have to rebuild the engine. 94 00:05:33,021 --> 00:05:35,855 Freeman: Every cell in our bodies 95 00:05:35,857 --> 00:05:41,461 have tiny engines called mitochondria. 96 00:05:41,463 --> 00:05:44,464 Mitochondria are double-membraned structures 97 00:05:44,466 --> 00:05:48,435 whose job is to provide energy. 98 00:05:48,437 --> 00:05:51,004 But when these powerhouses wear down, 99 00:05:51,006 --> 00:05:55,308 our body begins to decay and age. 100 00:05:55,310 --> 00:05:59,446 And so, you can imagine in the cells, instead, 101 00:05:59,448 --> 00:06:01,881 you have hundreds of these mitochondria, 102 00:06:01,883 --> 00:06:03,283 these little engines. 103 00:06:03,285 --> 00:06:06,386 And these hundreds of engines provide the energy locally 104 00:06:06,388 --> 00:06:08,655 to every single cell in our body. 105 00:06:08,657 --> 00:06:11,257 Freeman: But Valter has found a way 106 00:06:11,259 --> 00:06:13,960 to reverse this deterioration process 107 00:06:13,962 --> 00:06:18,665 and rejuvenate mitochondria in one tiny organism. 108 00:06:18,667 --> 00:06:21,534 He has extended the life of baker's yeast -- 109 00:06:21,536 --> 00:06:26,172 the kind you use to make bread and beer -- to 10 weeks. 110 00:06:26,174 --> 00:06:31,711 That's 10 times the yeast's normal life-span of 6 days. 111 00:06:31,713 --> 00:06:35,448 It may not sound like a long time, 112 00:06:35,450 --> 00:06:40,420 but it's equivalent to 800 human years. 113 00:06:40,422 --> 00:06:43,189 The yeast's longevity occurred 114 00:06:43,191 --> 00:06:48,528 when two genes, R.A.S.2 and S.C.H.9, 115 00:06:48,530 --> 00:06:50,730 were removed from its DNA. 116 00:06:50,732 --> 00:06:54,801 Longo: So these pathways that we've identified in yeast, 117 00:06:54,803 --> 00:06:59,239 in addition to promoting aging, they also promote DNA damage 118 00:06:59,241 --> 00:07:00,774 and the damage 119 00:07:00,776 --> 00:07:03,309 of a variety of different systems within the cells. 120 00:07:03,311 --> 00:07:06,146 Freeman: Valter wondered if this fountain of youth for yeast 121 00:07:06,148 --> 00:07:09,683 might apply to more complex life-forms. 122 00:07:09,685 --> 00:07:13,753 And so he began looking for the equivalent genes 123 00:07:13,755 --> 00:07:17,257 in a much larger organism -- 124 00:07:17,259 --> 00:07:19,225 mice. 125 00:07:19,227 --> 00:07:22,262 When he knocked out those two genes, 126 00:07:22,264 --> 00:07:26,132 these mice doubled their life expectancy. 127 00:07:26,134 --> 00:07:28,301 Longo: This is very encouraging 128 00:07:28,303 --> 00:07:30,870 because if you look at the similarities 129 00:07:30,872 --> 00:07:33,573 between a mouse and a human, 130 00:07:33,575 --> 00:07:36,776 we are over 90% identical in many ways. 131 00:07:36,778 --> 00:07:41,448 A mouse lives for 2 years, and people live for 100 years. 132 00:07:41,450 --> 00:07:42,782 So, you can see, 133 00:07:42,784 --> 00:07:45,719 with just a small modification of the genome, 134 00:07:45,721 --> 00:07:48,488 you can go from 2 years to 100 years. 135 00:07:48,490 --> 00:07:50,857 There's no law of physics 136 00:07:50,859 --> 00:07:54,227 that prevents us from finding the secret of longevity, 137 00:07:54,229 --> 00:07:57,864 the secret, perhaps, even of immortality. 138 00:07:57,866 --> 00:08:02,235 If you take, for example, the genome of millions of old people 139 00:08:02,237 --> 00:08:04,904 and the genome of millions of young people -- 140 00:08:04,906 --> 00:08:07,941 which we will do in the coming years -- and subtract, 141 00:08:07,943 --> 00:08:12,779 you will then find the genes where aging is concentrated. 142 00:08:12,781 --> 00:08:15,782 Already, we've identified over 60 genes 143 00:08:15,784 --> 00:08:17,951 involved in the aging process. 144 00:08:17,953 --> 00:08:19,452 Longo: Now, the question is, 145 00:08:19,454 --> 00:08:23,623 how do you reprogram a human that lives 100 years 146 00:08:23,625 --> 00:08:26,726 to be now a 2,000- or 3,000-year-old person? 147 00:08:26,728 --> 00:08:28,328 [ Engine revving ] 148 00:08:28,330 --> 00:08:31,231 Freeman: Valter's mission to keep our engines running forever 149 00:08:31,233 --> 00:08:35,401 has just begun, and he's in it for the long haul. 150 00:08:35,403 --> 00:08:37,103 Suppose we do find a way 151 00:08:37,105 --> 00:08:40,540 to keep our engines running for hundreds of years or more. 152 00:08:40,542 --> 00:08:45,011 We would all be very old for a very long time. 153 00:08:45,013 --> 00:08:46,980 But this scientist 154 00:08:46,982 --> 00:08:51,818 is digging for ways to keep us not just eternally alive... 155 00:08:51,820 --> 00:08:54,120 But eternally young. 156 00:08:58,183 --> 00:09:00,418 Take our current life-span 157 00:09:00,420 --> 00:09:05,023 and stretch it 5 or even 10 times longer. 158 00:09:05,025 --> 00:09:09,794 The joys of our youth would endure like an endless summer. 159 00:09:09,796 --> 00:09:14,932 But imagine suffering decade after decade with fragile bones, 160 00:09:14,934 --> 00:09:19,771 failing eyesight, and an ever-more-feeble mind. 161 00:09:19,773 --> 00:09:24,709 If we want to become immortal, we can't just extend life. 162 00:09:24,711 --> 00:09:30,748 We need to discover how to keep our bodies eternally youthful. 163 00:09:34,153 --> 00:09:39,424 Aubrey de Grey thinks of himself as a modern-day Methuselah. 164 00:09:39,426 --> 00:09:43,895 He has dedicated his career to fighting aging. 165 00:09:43,897 --> 00:09:47,231 Aubrey believes that many people who are born today 166 00:09:47,233 --> 00:09:49,734 could live to be 1,000 years old 167 00:09:49,736 --> 00:09:53,237 and remain physically young for most of that time. 168 00:09:53,239 --> 00:09:57,275 The key is a matter of good biological housekeeping -- 169 00:09:57,277 --> 00:10:00,345 taking the trash out of ourselves. 170 00:10:00,347 --> 00:10:02,013 So, what happens, indeed, 171 00:10:02,015 --> 00:10:05,016 is that certain types of material in the body 172 00:10:05,018 --> 00:10:07,151 just accumulate junk. 173 00:10:07,153 --> 00:10:11,556 Certain types of junk accumulate inside cells and between cells 174 00:10:11,558 --> 00:10:14,192 and stuff that we would not think of as junk, like DNA, 175 00:10:14,194 --> 00:10:18,596 accumulates randomness, which is a type of junk. 176 00:10:18,598 --> 00:10:20,631 Freeman: Cells have the important job 177 00:10:20,633 --> 00:10:23,000 of constantly breaking down waste, 178 00:10:23,002 --> 00:10:25,436 and they're mostly pretty good at it. 179 00:10:25,438 --> 00:10:26,571 But sometimes a cell 180 00:10:26,573 --> 00:10:29,273 comes across things that are so weird... 181 00:10:29,275 --> 00:10:32,710 None of this degradation machinery works on them. 182 00:10:32,712 --> 00:10:34,746 That's when the junk gets re-routed 183 00:10:34,748 --> 00:10:37,048 to what's called the lysosome, 184 00:10:37,050 --> 00:10:38,950 a vessel that houses 185 00:10:38,952 --> 00:10:42,420 the most powerful degradation machinery in the cell. 186 00:10:42,422 --> 00:10:45,022 And if the garbage can't be broken down, 187 00:10:45,024 --> 00:10:47,725 it stays there forever. 188 00:10:49,795 --> 00:10:53,398 Aubrey believes that the accumulation of garbage 189 00:10:53,400 --> 00:10:57,135 in the lysosomal storage unit is what causes aging. 190 00:10:57,137 --> 00:11:01,172 And he wants to free our bodies of these buildups. 191 00:11:01,174 --> 00:11:03,141 He realized the most logical way 192 00:11:03,143 --> 00:11:06,677 was to take a close look at waste itself. 193 00:11:06,679 --> 00:11:12,717 And he wondered, "In nature, what likes to eat junk?" 194 00:11:12,719 --> 00:11:14,852 Longo: We're working on an idea 195 00:11:14,854 --> 00:11:17,422 that we might be able to find other species, 196 00:11:17,424 --> 00:11:21,259 especially bacteria, that are able to break down 197 00:11:21,261 --> 00:11:24,729 the substances that accumulate in the human body. 198 00:11:24,731 --> 00:11:28,065 Freeman: Aubrey's hunt for the fountain of youth 199 00:11:28,067 --> 00:11:32,570 led him to a final resting place -- graveyards. 200 00:11:34,339 --> 00:11:36,007 Since graveyards are riddled 201 00:11:36,009 --> 00:11:39,010 with the waste of decomposing bodies, 202 00:11:39,012 --> 00:11:41,412 he suspected he might find microbes 203 00:11:41,414 --> 00:11:44,115 who live to feast on death. 204 00:11:44,117 --> 00:11:49,587 [De Grey] And if we can find the genes and enzymes that they are using 205 00:11:49,589 --> 00:11:51,589 to actually perform that function, 206 00:11:51,591 --> 00:11:54,725 then we might be able to put those genes and enzymes 207 00:11:54,727 --> 00:11:56,894 into our own cells 208 00:11:56,896 --> 00:11:58,896 so that our own cells can break stuff down 209 00:11:58,898 --> 00:12:00,832 that they could not naturally break down. 210 00:12:00,834 --> 00:12:04,335 Freeman: The secret to longevity might be 6 feet under. 211 00:12:04,337 --> 00:12:10,074 Aubrey and his team are still digging for the right microbe 212 00:12:10,076 --> 00:12:11,576 that will work in mammalian cells. 213 00:12:11,578 --> 00:12:13,444 And when they find it, 214 00:12:13,446 --> 00:12:19,350 he believes we will all live like 25-year-olds forever. 215 00:12:19,352 --> 00:12:23,154 [De Grey] I think that we have maybe a 50/50 chance 216 00:12:23,156 --> 00:12:25,857 in the next 25 years or so 217 00:12:25,859 --> 00:12:28,826 of developing what I think of as the first generation 218 00:12:28,828 --> 00:12:31,596 of bona fide rejuvenation biotechnology. 219 00:12:31,598 --> 00:12:32,897 In other words, 220 00:12:32,899 --> 00:12:35,533 technologies that are sufficiently comprehensive 221 00:12:35,535 --> 00:12:39,103 that we can give them to middle-aged people, 222 00:12:39,105 --> 00:12:42,940 people 60 or 70 or so, and fix them up well enough 223 00:12:42,942 --> 00:12:46,744 that they don't become biologically 60 or 70 again 224 00:12:46,746 --> 00:12:49,213 until 30 years later or something like that. 225 00:12:51,817 --> 00:12:55,620 Freeman: Aubrey is looking for the magic bullet that will fight aging, 226 00:12:55,622 --> 00:12:58,222 but synthetic biologist Chris Voigt 227 00:12:58,224 --> 00:13:01,492 is looking to build an entire army 228 00:13:01,494 --> 00:13:04,629 out of various parts from all over nature. 229 00:13:06,765 --> 00:13:10,401 Voigt: All right. Let's give this a shot. 230 00:13:14,740 --> 00:13:17,074 One of the things we're often trying to do 231 00:13:17,076 --> 00:13:19,443 in synthetic biology is create new functions 232 00:13:19,445 --> 00:13:23,047 out of parts that already exist in nature for other reason 233 00:13:23,049 --> 00:13:26,484 so we're often having to go out and grab those components 234 00:13:26,486 --> 00:13:29,387 from different organisms and put them together. 235 00:13:29,389 --> 00:13:32,356 Freeman: Chris searches for microorganisms 236 00:13:32,358 --> 00:13:36,193 throughout biology to find the right parts. 237 00:13:36,195 --> 00:13:38,663 And they end up at his lab 238 00:13:38,665 --> 00:13:41,799 at the University of California, San Francisco, 239 00:13:41,801 --> 00:13:45,102 where biology meets mechanics. 240 00:13:45,104 --> 00:13:47,939 Voigt: When you look at being able to fight disease, 241 00:13:47,941 --> 00:13:49,807 whether it's identifying malignant cells 242 00:13:49,809 --> 00:13:51,242 and killing them, 243 00:13:51,244 --> 00:13:53,511 we're trying to go through the garbage of all the functions 244 00:13:53,513 --> 00:13:55,012 that are out in the natural world 245 00:13:55,014 --> 00:13:58,549 and identify those that are useful to us 246 00:13:58,551 --> 00:14:00,685 in trying to be able to identify 247 00:14:00,687 --> 00:14:03,254 a correct disease state in the body. 248 00:14:03,256 --> 00:14:07,091 Freeman: To build a bio robot that can detect its surroundings, 249 00:14:07,093 --> 00:14:11,062 Chris and his team needed to find an organism with a sensor. 250 00:14:11,064 --> 00:14:15,299 And they found it... In pond scum... 251 00:14:15,301 --> 00:14:20,271 Where they discovered that algae are equipped with light sensors. 252 00:14:20,273 --> 00:14:23,507 Voigt: We took a bacterium that normally lives in your gut -- 253 00:14:23,509 --> 00:14:26,110 so it's not used to the Sun shining -- 254 00:14:26,112 --> 00:14:29,146 and we put in a light sensor out of an algae. 255 00:14:29,148 --> 00:14:32,950 Freeman: Inside Chris' bacterial darkroom, 256 00:14:32,952 --> 00:14:35,086 colonies of bacteria 257 00:14:35,088 --> 00:14:36,887 that are now implanted with algae light sensors 258 00:14:36,889 --> 00:14:40,257 are able to take photographs of slide-projected images. 259 00:14:42,494 --> 00:14:45,196 Freeman: It might look like bacterial art, 260 00:14:45,198 --> 00:14:47,331 but this is the first big step 261 00:14:47,333 --> 00:14:50,635 toward creating programmable biological robots 262 00:14:50,637 --> 00:14:53,304 that will keep our bodies healthy forever. 263 00:14:53,306 --> 00:14:56,841 Voigt: There are bacteria all throughout our bodies, 264 00:14:56,843 --> 00:14:59,944 and we can reprogram those bacteria 265 00:14:59,946 --> 00:15:03,147 in order to be able to implement therapeutic effects 266 00:15:03,149 --> 00:15:06,617 for just about any disease that you can imagine. 267 00:15:06,619 --> 00:15:10,554 The possibilities are limitless. 268 00:15:10,556 --> 00:15:13,257 Freeman: Chris' photographic bacteria 269 00:15:13,259 --> 00:15:15,493 are able to turn themselves on and off 270 00:15:15,495 --> 00:15:16,961 like the flip of a switch. 271 00:15:16,963 --> 00:15:18,529 But the question is, 272 00:15:18,531 --> 00:15:23,968 can Chris figure out how to program and control that switch? 273 00:15:23,970 --> 00:15:26,070 We'd like to see the programming of cells 274 00:15:26,072 --> 00:15:28,005 be the same as programming a computer 275 00:15:28,007 --> 00:15:29,540 or designing an electronic chip, 276 00:15:29,542 --> 00:15:32,209 where, as programmers, we would write out 277 00:15:32,211 --> 00:15:35,379 the exact function that we'd want the cells to do. 278 00:15:35,381 --> 00:15:38,282 And then that would be automatically compiled 279 00:15:38,284 --> 00:15:39,583 into a DNA sequence 280 00:15:39,585 --> 00:15:41,686 in the same way that a computer program 281 00:15:41,688 --> 00:15:45,122 gets compiled, ultimately, into ones and zeroes. 282 00:15:45,124 --> 00:15:46,457 That's the dream. 283 00:15:46,459 --> 00:15:48,993 [ Gulp! ] 284 00:15:48,995 --> 00:15:52,096 Freeman: Bio robots may one day roam our blood streams, 285 00:15:52,098 --> 00:15:56,634 police our organs, and respond to our internal 911 calls, 286 00:15:56,636 --> 00:16:00,671 keeping us free from the threat of disease. 287 00:16:02,340 --> 00:16:05,609 Chris Voigt's and Aubrey de Grey's research 288 00:16:05,611 --> 00:16:07,845 to keep our bodies healthy for eternity 289 00:16:07,847 --> 00:16:09,914 is still in the beginning stages. 290 00:16:09,916 --> 00:16:13,050 But what does this mean for us mere mortals 291 00:16:13,052 --> 00:16:15,619 who will never live to see the day 292 00:16:15,621 --> 00:16:18,055 when immortality is within reach? 293 00:16:18,057 --> 00:16:21,192 There is one chilling possibility 294 00:16:21,194 --> 00:16:27,698 that will give us all a chance to hang on, even after we die. 295 00:16:31,872 --> 00:16:34,674 We're all genetically programmed 296 00:16:34,676 --> 00:16:38,411 to lust for life and to flee from death. 297 00:16:38,413 --> 00:16:43,283 Eventually, we will discover the secret of immortality, 298 00:16:43,285 --> 00:16:45,585 but we're not there yet. 299 00:16:45,587 --> 00:16:50,690 To cheat death right now, we need to put aging on ice 300 00:16:50,692 --> 00:16:55,128 and be ready to grasp eternal life 301 00:16:55,130 --> 00:16:58,465 long after life abandons us. 302 00:17:01,635 --> 00:17:04,404 Greg Fahy is a cryobiologist. 303 00:17:04,406 --> 00:17:09,976 The goal of his team at biotech outfit 21st Century Medicine 304 00:17:09,978 --> 00:17:13,146 is to freeze human organs and tissues 305 00:17:13,148 --> 00:17:17,851 so that they can be revived, undamaged, centuries from now. 306 00:17:19,453 --> 00:17:22,021 Fahy: Cryopreservation is the preservation of living systems 307 00:17:22,023 --> 00:17:23,857 at very low temperatures. 308 00:17:23,859 --> 00:17:27,327 We usually are referring to temperatures that are low enough 309 00:17:27,329 --> 00:17:30,597 that you can store the system as long as you wish 310 00:17:30,599 --> 00:17:32,232 before you use it again. 311 00:17:32,234 --> 00:17:34,501 Cryopreservation is essential 312 00:17:34,503 --> 00:17:36,936 to get a cell or a tissue, an organ, 313 00:17:36,938 --> 00:17:39,939 from one place in time to another place in time 314 00:17:39,941 --> 00:17:43,843 without allowing that system to change in the process. 315 00:17:43,845 --> 00:17:46,112 Freeman: Scientists have been trying 316 00:17:46,114 --> 00:17:48,815 to preserve whole organs for decades. 317 00:17:48,817 --> 00:17:52,652 But it's a lot harder than throwing food in the freezer. 318 00:17:52,654 --> 00:17:58,525 When biological material freezes, ice crystals form, 319 00:17:58,527 --> 00:18:02,128 which push the cells out of their normal position. 320 00:18:02,130 --> 00:18:06,466 When you thaw the organ, it may look okay from the outside, 321 00:18:06,468 --> 00:18:10,870 but on the inside, it's damaged beyond repair. 322 00:18:12,940 --> 00:18:16,109 The biggest problem, we think, is really mechanical. 323 00:18:16,111 --> 00:18:18,678 It's the formation of ice between cells. 324 00:18:18,680 --> 00:18:21,848 If the cells are dislodged from their normal locations, 325 00:18:21,850 --> 00:18:23,082 then you can destroy 326 00:18:23,084 --> 00:18:25,752 the function of that structure as a whole 327 00:18:25,754 --> 00:18:27,420 even if the cells survive. 328 00:18:29,590 --> 00:18:32,625 Freeman: Greg and his team decided to focus their efforts 329 00:18:32,627 --> 00:18:34,527 on preventing bodily fluids from freezing 330 00:18:34,529 --> 00:18:36,629 and eventually developed a way 331 00:18:36,631 --> 00:18:41,501 to turn those fluids into a form of biological glass -- 332 00:18:41,503 --> 00:18:45,471 a technique he calls vitrification. 333 00:18:45,473 --> 00:18:48,708 Fahy: Vitrification is the formation of a glass. 334 00:18:48,710 --> 00:18:52,111 So if you take water and you mix it with various chemicals 335 00:18:52,113 --> 00:18:54,347 in high-enough concentrations of chemical 336 00:18:54,349 --> 00:18:56,849 and then cool it down to low temperatures, 337 00:18:56,851 --> 00:18:59,986 the system will never freeze no matter how low you go. 338 00:18:59,988 --> 00:19:01,454 Freeman: To test whether 339 00:19:01,456 --> 00:19:05,758 vitrification actually preserves the function of whole organs, 340 00:19:05,760 --> 00:19:09,896 Greg's team vitrified a rabbit kidney. 341 00:19:09,898 --> 00:19:13,232 Fahy: This is the kidney profusion lab. 342 00:19:13,234 --> 00:19:15,401 What John is doing in the background 343 00:19:15,403 --> 00:19:18,538 is delivering...through the vascular system of the kidney 344 00:19:18,540 --> 00:19:20,907 so the kidney becomes unfreezable. 345 00:19:20,909 --> 00:19:24,077 The kidney is sitting in a special chamber. 346 00:19:24,079 --> 00:19:25,545 The chamber is temperature-conditioned 347 00:19:25,547 --> 00:19:26,913 to minimize toxicity. 348 00:19:26,915 --> 00:19:28,748 And at the end of the process, 349 00:19:28,750 --> 00:19:30,850 the kidney's taken out and is transplanted. 350 00:19:30,852 --> 00:19:33,453 Freeman: This kidney, 351 00:19:33,455 --> 00:19:38,558 even though it has been stored at minus-22 degrees celsius, 352 00:19:38,560 --> 00:19:41,361 works just as well as a normal kidney. 353 00:19:41,363 --> 00:19:42,528 It's proof 354 00:19:42,530 --> 00:19:45,999 that Greg's vitrification technique actually works 355 00:19:46,001 --> 00:19:47,400 and might be the key 356 00:19:47,402 --> 00:19:52,538 to preserving human organs far into the future. 357 00:19:52,540 --> 00:19:56,409 So if you cool to below that glass-transition temperature, 358 00:19:56,411 --> 00:19:59,178 our calculations indicate you can store a system 359 00:19:59,180 --> 00:20:00,947 for tens of thousands of years. 360 00:20:00,949 --> 00:20:05,485 Freeman: Imagine being able to put your body on ice 361 00:20:05,487 --> 00:20:10,289 and then being revived 10,000 years from now. 362 00:20:10,291 --> 00:20:12,792 You could wake up and find yourself 363 00:20:12,794 --> 00:20:17,630 in an age when science has made immortality possible. 364 00:20:17,632 --> 00:20:19,999 Greg Fahy may be just a few years 365 00:20:20,001 --> 00:20:24,604 from giving a few select people a shot at eternal life. 366 00:20:24,606 --> 00:20:26,439 But that can only happen 367 00:20:26,441 --> 00:20:29,709 if cryopreservation works on an entire human body, 368 00:20:29,711 --> 00:20:33,079 not just simple organs like the kidney or the bladder, 369 00:20:33,081 --> 00:20:38,751 but on the most complex organ of all -- the brain. 370 00:20:38,753 --> 00:20:41,287 Fahy: This is the brain-slice vitrification lab. 371 00:20:41,289 --> 00:20:44,290 The setup shows a hippocampal slice -- 372 00:20:44,292 --> 00:20:47,727 the part of the brain that's associated with learning and memory -- 373 00:20:47,729 --> 00:20:50,596 in a little dish, essentially. 374 00:20:50,598 --> 00:20:53,599 On the right side, we have a stimulating electrode coming in, 375 00:20:53,601 --> 00:20:54,901 piercing the slice. 376 00:20:54,903 --> 00:20:57,937 On the left side, we have a recording electrode. 377 00:20:59,306 --> 00:21:03,076 Freeman: This brain slice has been vitrified. 378 00:21:03,078 --> 00:21:05,044 If it's still functional, 379 00:21:05,046 --> 00:21:08,514 when a pulse of electricity is fired into it, 380 00:21:08,516 --> 00:21:10,717 it should fire a signal back. 381 00:21:10,719 --> 00:21:14,487 To Greg and his team's surprise, it does. 382 00:21:14,489 --> 00:21:19,258 Electrical activity actually sparks up in this brain tissue. 383 00:21:19,260 --> 00:21:20,993 And the electrical response 384 00:21:20,995 --> 00:21:26,332 is every bit as strong as it was in its original state -- 385 00:21:26,334 --> 00:21:30,169 the recovery of the brain slice complete. 386 00:21:30,171 --> 00:21:33,406 Preserving a slice of the brain 387 00:21:33,408 --> 00:21:38,177 is a crucial first step toward preserving the whole thing. 388 00:21:38,179 --> 00:21:42,715 It's an ambitious project that Greg is already working on. 389 00:21:42,717 --> 00:21:47,353 We have found that it's fairly easy to vitrify the brain, 390 00:21:47,355 --> 00:21:51,157 that all of the structure seems to be preserved. 391 00:21:51,159 --> 00:21:53,259 But I have to say that so far, 392 00:21:53,261 --> 00:21:55,928 our techniques are not up to the level 393 00:21:55,930 --> 00:21:59,398 that we would like for that kind of speculative idea. 394 00:21:59,400 --> 00:22:02,034 But I couldn't say that you couldn't make up 395 00:22:02,036 --> 00:22:04,270 for whatever deficiencies 396 00:22:04,272 --> 00:22:07,140 that we have in our preservation technique today 397 00:22:07,142 --> 00:22:09,809 using some unknown future technology. 398 00:22:09,811 --> 00:22:12,411 I can't rule that out as a possibility. 399 00:22:16,016 --> 00:22:22,054 One day, centuries after we say goodbye to our loved ones, 400 00:22:22,056 --> 00:22:25,424 our frozen bodies could be reanimated, 401 00:22:25,426 --> 00:22:28,461 and we'll walk the earth again. 402 00:22:28,463 --> 00:22:31,597 But there could be a better route to immortality, 403 00:22:31,599 --> 00:22:33,266 one that would change 404 00:22:33,268 --> 00:22:36,936 the very nature of what it means to be human. 405 00:22:39,623 --> 00:22:42,458 Imagine if no one ever died. 406 00:22:42,460 --> 00:22:44,727 Where would we all live? 407 00:22:44,729 --> 00:22:47,496 Our planet is already crowded enough. 408 00:22:47,498 --> 00:22:50,433 But maybe there is a way to live forever 409 00:22:50,435 --> 00:22:54,203 without all this excess baggage. 410 00:22:54,205 --> 00:22:57,807 Poets say the essence of us is here, 411 00:22:57,809 --> 00:23:03,112 but I know what really makes me me is all up here. 412 00:23:03,114 --> 00:23:06,482 So if I want to endure for eternity, 413 00:23:06,484 --> 00:23:09,986 perhaps that's all I need to hang on to. 414 00:23:09,988 --> 00:23:14,323 What if we could find a way to upload our brains, 415 00:23:14,325 --> 00:23:17,927 to digitize the very essence of ourselves? 416 00:23:17,929 --> 00:23:22,565 Our minds could go on living long after our flesh has died. 417 00:23:22,567 --> 00:23:24,100 But to make that happen, 418 00:23:24,102 --> 00:23:27,036 we need to understand the brain's architecture 419 00:23:27,038 --> 00:23:31,107 and figure out what truly makes us who we are. 420 00:23:33,310 --> 00:23:38,481 Olaf Sporns is a neuroscientist at Indiana University. 421 00:23:38,483 --> 00:23:43,552 He is attempting to unscramble the brain's tangled web. 422 00:23:43,554 --> 00:23:45,187 Sporns: The brain is like a big city. 423 00:23:45,189 --> 00:23:48,124 Cities are examples of complex systems -- 424 00:23:48,126 --> 00:23:50,459 thousands of inhabitants and their social interactions, 425 00:23:50,461 --> 00:23:51,627 their flow of materials. 426 00:23:51,629 --> 00:23:54,930 The brain is like that -- millions of neurons, 427 00:23:54,932 --> 00:23:57,400 interactions between these neurons. 428 00:23:57,402 --> 00:24:00,703 In a sense, your brain is like a city of the mind. 429 00:24:00,705 --> 00:24:02,772 Freeman: The human brain 430 00:24:02,774 --> 00:24:06,309 is one of the most complex systems in the Universe. 431 00:24:06,311 --> 00:24:10,546 If you stretched out all of its electrical wiring, 432 00:24:10,548 --> 00:24:13,983 it would extend from the Earth to the Moon. 433 00:24:13,985 --> 00:24:17,486 Figuring out how we get from cells and wires 434 00:24:17,488 --> 00:24:19,989 to thoughts and memories 435 00:24:19,991 --> 00:24:24,493 is one of the greatest challenges known to science. 436 00:24:24,495 --> 00:24:26,796 Even though we've been studying the human brain, 437 00:24:26,798 --> 00:24:28,698 really, for decades, perhaps centuries, 438 00:24:28,700 --> 00:24:31,367 we still don't have a complete map of how it's connected. 439 00:24:31,369 --> 00:24:34,403 Freeman: But Olaf is taking on this challenge. 440 00:24:34,405 --> 00:24:39,208 His goal is to chart every single neuron and synapse 441 00:24:39,210 --> 00:24:43,446 and create a complete map of the brain, called the connectome. 442 00:24:43,448 --> 00:24:45,715 Sporns: It's a comprehensive set of connections 443 00:24:45,717 --> 00:24:47,650 that will allow us for the first time 444 00:24:47,652 --> 00:24:49,051 to understand in more detail 445 00:24:49,053 --> 00:24:51,387 how brain regions are connected to each other. 446 00:24:51,389 --> 00:24:53,923 Freeman: Olaf is creating the connectome 447 00:24:53,925 --> 00:24:58,027 using a leading-edge technique called diffusion imaging. 448 00:24:58,029 --> 00:25:00,863 It reveals the brain's long-distance connections 449 00:25:00,865 --> 00:25:04,066 by tracking water molecules along the neural highways. 450 00:25:04,068 --> 00:25:07,770 And what emerges is a detailed map 451 00:25:07,772 --> 00:25:11,207 of the central core of brain-cell connections. 452 00:25:11,209 --> 00:25:16,345 Olaf thinks this is the area where our personality resides. 453 00:25:16,347 --> 00:25:18,547 Sporns: As we've been discovering recently, 454 00:25:18,549 --> 00:25:21,050 some brain regions are more connected than others. 455 00:25:21,052 --> 00:25:23,052 Some are more essential, perhaps, 456 00:25:23,054 --> 00:25:25,020 for the functioning of the brain as a whole. 457 00:25:25,022 --> 00:25:28,324 Those regions, we call hubs. 458 00:25:28,326 --> 00:25:30,025 Freeman: If the brain is like a city... 459 00:25:30,027 --> 00:25:31,127 [ Tires screech ] 460 00:25:31,129 --> 00:25:33,396 ...Hubs are like major intersections 461 00:25:33,398 --> 00:25:36,098 where a constant flow of traffic passes through, 462 00:25:36,100 --> 00:25:38,567 getting people from one place to another. 463 00:25:38,569 --> 00:25:39,969 [ Bell clangs ] 464 00:25:39,971 --> 00:25:42,738 These intersections are so essential -- 465 00:25:42,740 --> 00:25:47,176 if they become disrupted in any way, the whole city shuts down. 466 00:25:47,178 --> 00:25:48,677 [ Sloop! ] 467 00:25:48,679 --> 00:25:53,015 By their nature, hubs are focal points of information traffic. 468 00:25:53,017 --> 00:25:55,451 Information converges on these regions, 469 00:25:55,453 --> 00:25:58,053 and it is that ebb and flow of information 470 00:25:58,055 --> 00:26:00,589 and the magnitude of the information flow 471 00:26:00,591 --> 00:26:02,491 that really sets these hubs apart 472 00:26:02,493 --> 00:26:04,326 from other regions of the brain. 473 00:26:04,328 --> 00:26:06,395 Freeman: Olaf is getting closer 474 00:26:06,397 --> 00:26:09,398 to figuring out where consciousness resides. 475 00:26:09,400 --> 00:26:12,301 Searching for the origins of consciousness 476 00:26:12,303 --> 00:26:15,004 is the holy grail of neuroscience. 477 00:26:15,006 --> 00:26:18,808 Only when this mystery is solved can we replicate the human brain 478 00:26:18,810 --> 00:26:21,610 and take consciousness from a person 479 00:26:21,612 --> 00:26:26,882 and transfer it to a machine as a way to live for eternity. 480 00:26:26,884 --> 00:26:31,086 And Olaf believes he has discovered a hub 481 00:26:31,088 --> 00:26:36,158 that might solve this mystery -- the medial parietal cortex. 482 00:26:36,160 --> 00:26:39,862 It's located between the brain's two hemispheres. 483 00:26:39,864 --> 00:26:45,367 Olaf suspects it might house the essence of who we are. 484 00:26:45,369 --> 00:26:48,537 Sporns: A lot of wires from the brain converge on that region. 485 00:26:48,539 --> 00:26:50,206 There are many lines of evidence 486 00:26:50,208 --> 00:26:52,374 that point to that part of the brain 487 00:26:52,376 --> 00:26:54,577 being really central and really important -- 488 00:26:54,579 --> 00:26:57,146 perhaps even for awareness and consciousness. 489 00:26:58,782 --> 00:27:00,049 Freeman: Olaf believes 490 00:27:00,051 --> 00:27:03,986 he may have solved the secrets of consciousness, 491 00:27:03,988 --> 00:27:08,123 but there is much more work to be done before he can be sure. 492 00:27:08,125 --> 00:27:11,494 Sporns: I think we're getting closer to answering this question. 493 00:27:11,496 --> 00:27:14,897 And as we identify which parts of the brain are critical 494 00:27:14,899 --> 00:27:17,900 in bringing about that particular functionality, 495 00:27:17,902 --> 00:27:20,269 that gets us closer to answering the question, 496 00:27:20,271 --> 00:27:21,604 "What is consciousness?" 497 00:27:21,606 --> 00:27:24,306 And also "Where are the critical components of the brain 498 00:27:24,308 --> 00:27:25,875 that contribute to it?" 499 00:27:25,877 --> 00:27:27,076 [ Electricity crackling ] 500 00:27:27,078 --> 00:27:29,712 Freeman: Neuroscience has taken enormous steps 501 00:27:29,714 --> 00:27:31,146 towards mapping the brain 502 00:27:31,148 --> 00:27:33,516 and solving the riddle of consciousness. 503 00:27:33,518 --> 00:27:36,185 But will we ever be able to capture 504 00:27:36,187 --> 00:27:39,588 the trillions of synapses, billions of neurons, 505 00:27:39,590 --> 00:27:43,826 and download ourselves onto a machine? 506 00:27:43,828 --> 00:27:46,729 Just imagine all the things that happen in the real world -- 507 00:27:46,731 --> 00:27:48,664 the conversation we are having now, 508 00:27:48,666 --> 00:27:50,866 me producing speech sounds and gestures, 509 00:27:50,868 --> 00:27:53,903 our brain's interacting in this embodied manner. 510 00:27:53,905 --> 00:27:56,272 That could not happen in a computer, 511 00:27:56,274 --> 00:27:57,406 and yet, it is somehow 512 00:27:57,408 --> 00:27:59,408 the essence of what life is all about. 513 00:27:59,410 --> 00:28:00,809 So I'm skeptical about that. 514 00:28:02,546 --> 00:28:06,849 Freeman: The brain might be far too complex to immortalize, 515 00:28:06,851 --> 00:28:11,554 but maybe there's a simpler path to eternal life -- 516 00:28:11,556 --> 00:28:13,022 not for you... 517 00:28:13,024 --> 00:28:18,027 But for immortal beings that we create from scratch. 518 00:28:21,244 --> 00:28:22,478 Life on this planet 519 00:28:22,480 --> 00:28:25,681 has had 4 billion years to evolve. 520 00:28:25,683 --> 00:28:30,119 We are the latest in a long line of species. 521 00:28:30,121 --> 00:28:32,521 We hope we're the last. 522 00:28:32,523 --> 00:28:37,693 But our quest for immortality could end in disaster 523 00:28:37,695 --> 00:28:42,998 because the first eternal beings may not be human. 524 00:28:43,000 --> 00:28:48,304 And they might just make us extinct. 525 00:28:51,241 --> 00:28:55,511 Complex life began from a few simple laws. 526 00:28:55,513 --> 00:29:00,216 The same might be true for artificial life. 527 00:29:00,218 --> 00:29:03,319 If humans discover those laws, there is a chance 528 00:29:03,321 --> 00:29:07,256 we could create living things that live forever. 529 00:29:07,258 --> 00:29:12,261 Oxford Physicist Vlatko Vedral is trying to understand 530 00:29:12,263 --> 00:29:15,764 how intelligence might emerge from a system 531 00:29:15,766 --> 00:29:19,502 that operates on just a few basic ground rules. 532 00:29:19,504 --> 00:29:21,637 Vedral: So, this is chess. 533 00:29:21,639 --> 00:29:23,439 It's a very complex game, 534 00:29:23,441 --> 00:29:27,476 and yet it's governed by a few very simple rules. 535 00:29:27,478 --> 00:29:31,113 You really have only 16 pieces on each side, 536 00:29:31,115 --> 00:29:33,582 and each piece can do one of two things. 537 00:29:33,584 --> 00:29:36,185 And you can say the same thing about life. 538 00:29:36,187 --> 00:29:37,786 Even though you are talking 539 00:29:37,788 --> 00:29:40,356 about one or two very simple rules, 540 00:29:40,358 --> 00:29:41,557 you still get this multitude 541 00:29:41,559 --> 00:29:44,293 of different possible behaviors in the Universe. 542 00:29:46,530 --> 00:29:50,533 Freeman: In 1970, a mathematician named John Conway 543 00:29:50,535 --> 00:29:52,368 ran with this idea 544 00:29:52,370 --> 00:29:55,204 and attempted to create artificial life-forms 545 00:29:55,206 --> 00:29:58,574 spontaneously using a computer program. 546 00:29:58,576 --> 00:30:01,010 He called it "The game of life." 547 00:30:01,012 --> 00:30:04,847 The game simulates the growth of artificial life, 548 00:30:04,849 --> 00:30:06,715 using a two-dimensional grid 549 00:30:06,717 --> 00:30:09,919 and simple cells that are either dead or alive. 550 00:30:09,921 --> 00:30:15,190 Whether the cells live or die is governed by a few basic rules. 551 00:30:15,192 --> 00:30:20,796 So, we have here in front of us a large cell block, 552 00:30:20,798 --> 00:30:24,466 and we can see this one central cell, which is on. 553 00:30:24,468 --> 00:30:29,905 And we can see that it has only one neighbor to its left. 554 00:30:29,907 --> 00:30:33,375 The cell just switches off, which means that it dies. 555 00:30:33,377 --> 00:30:35,044 And it dies of loneliness 556 00:30:35,046 --> 00:30:37,413 because it has too few neighbors. 557 00:30:37,415 --> 00:30:40,849 Well, now we've got a central cell, which is on, 558 00:30:40,851 --> 00:30:42,718 but it has five neighbors. 559 00:30:42,720 --> 00:30:45,721 It dies because of overcrowding, overpopulation. 560 00:30:45,723 --> 00:30:47,389 It doesn't like it, either. 561 00:30:47,391 --> 00:30:52,328 In the third example, a cell with only two neighbors -- 562 00:30:52,330 --> 00:30:54,296 the cell just keeps on living. 563 00:30:54,298 --> 00:30:57,266 It can even move around in this environment, 564 00:30:57,268 --> 00:30:58,734 and it can reproduce. 565 00:30:58,736 --> 00:31:02,237 So this is a good example where the population is just right 566 00:31:02,239 --> 00:31:04,807 for the cell to keep on living. 567 00:31:04,809 --> 00:31:08,143 Freeman: Given enough time, increasingly complex patterns 568 00:31:08,145 --> 00:31:11,013 emerge from this simple set of rules. 569 00:31:11,015 --> 00:31:15,417 Some even take on the appearance of living organisms. 570 00:31:15,419 --> 00:31:19,989 Vedral: John Conway tried to make the same point regarding life -- 571 00:31:19,991 --> 00:31:22,358 that it looks very complicated to us. 572 00:31:22,360 --> 00:31:24,660 And, indeed, it looks like a miracle 573 00:31:24,662 --> 00:31:26,395 that there is life around us, 574 00:31:26,397 --> 00:31:28,631 but, in fact, he constructed a game 575 00:31:28,633 --> 00:31:32,534 which consists of two or three, again, very simple rules, 576 00:31:32,536 --> 00:31:35,771 and it gives rise to some very complicated patterns. 577 00:31:35,773 --> 00:31:38,774 Freeman: How complex do these patterns need to be 578 00:31:38,776 --> 00:31:43,812 before they become something alive, intelligent, or immortal? 579 00:31:43,814 --> 00:31:47,616 Vlatko thinks the human brain is a good yardstick 580 00:31:47,618 --> 00:31:50,853 and has calculated its processing power. 581 00:31:50,855 --> 00:31:53,989 Vedral: The brain is currently still much more powerful 582 00:31:53,991 --> 00:31:55,624 than the existing computers. 583 00:31:55,626 --> 00:31:58,927 So the existing computers can do something like, you know, 584 00:31:58,929 --> 00:32:01,296 10 to the power of 12 beats per second, 585 00:32:01,298 --> 00:32:03,732 whereas our brain is still probably something 586 00:32:03,734 --> 00:32:06,135 like a million times faster than that. 587 00:32:06,137 --> 00:32:08,270 So you need 1 million laptops 588 00:32:08,272 --> 00:32:11,507 to simulate just a single human brain. 589 00:32:11,509 --> 00:32:14,843 Freeman: Today's computers are nowhere near powerful enough 590 00:32:14,845 --> 00:32:16,545 to house artificial intelligent life. 591 00:32:16,547 --> 00:32:19,148 Vlatko believes the answer might be to use 592 00:32:19,150 --> 00:32:21,316 a completely different type of computer -- 593 00:32:21,318 --> 00:32:23,852 the quantum computer. 594 00:32:23,854 --> 00:32:25,421 Quantum computer 595 00:32:25,423 --> 00:32:29,124 is basically the future technology of computation. 596 00:32:29,126 --> 00:32:32,661 It's a computer that's so fast, in principle, 597 00:32:32,663 --> 00:32:36,165 that no current computer can compete with it. 598 00:32:36,167 --> 00:32:38,634 Freeman: In place of transistors, 599 00:32:38,636 --> 00:32:41,970 quantum devices compute with individual atoms. 600 00:32:41,972 --> 00:32:45,374 And instead of sorting piles of ones and zeroes 601 00:32:45,376 --> 00:32:47,276 to give yes-and-no answers, 602 00:32:47,278 --> 00:32:49,344 the atoms in quantum computers 603 00:32:49,346 --> 00:32:52,681 can be ones, zeroes, and everything in between, 604 00:32:52,683 --> 00:32:56,885 existing as a computational maybe. 605 00:32:56,887 --> 00:32:59,354 The quantum computer really utilizes 606 00:32:59,356 --> 00:33:02,458 the quantum effect known as the super position, 607 00:33:02,460 --> 00:33:03,692 which means being 608 00:33:03,694 --> 00:33:06,495 in many different states at the same time. 609 00:33:06,497 --> 00:33:11,366 Freeman: This ability to handle a multiplicity of states 610 00:33:11,368 --> 00:33:13,368 allows quantum computers 611 00:33:13,370 --> 00:33:16,038 to juggle many overlapping problems at once, 612 00:33:16,040 --> 00:33:18,907 just the way our brains do. 613 00:33:20,210 --> 00:33:23,712 The analogy would be if I played a chord for you... 614 00:33:23,714 --> 00:33:26,415 [ Chord plays ] 615 00:33:26,417 --> 00:33:27,916 ...Then you would get 616 00:33:27,918 --> 00:33:31,520 many different modes played at the same time, 617 00:33:31,522 --> 00:33:33,088 which would really correspond 618 00:33:33,090 --> 00:33:36,125 to many states being out there simultaneously 619 00:33:36,127 --> 00:33:37,493 all in one location 620 00:33:37,495 --> 00:33:39,628 and the full power of quantum computation, 621 00:33:39,630 --> 00:33:41,797 which is actually unlimited, in some sense, 622 00:33:41,799 --> 00:33:42,998 if you start to store 623 00:33:43,000 --> 00:33:45,234 all the values in between the zero and the one. 624 00:33:45,236 --> 00:33:50,405 So then you really reach a stage where you can encode much more 625 00:33:50,407 --> 00:33:53,976 and the capacity really has no limits in that sense. 626 00:33:53,978 --> 00:33:55,444 Freeman: There might be a time 627 00:33:55,446 --> 00:33:58,847 when humans forego their own dream of immortality 628 00:33:58,849 --> 00:34:02,618 and create eternal artificial life. 629 00:34:02,620 --> 00:34:04,486 And if they do, 630 00:34:04,488 --> 00:34:07,523 how would artificial and biological life get along? 631 00:34:07,525 --> 00:34:10,659 Some people think that very soon 632 00:34:10,661 --> 00:34:14,163 computers will be smarter than us and they'll put us in zoos. 633 00:34:14,165 --> 00:34:17,833 They'll put us behind bars and throw peanuts at us 634 00:34:17,835 --> 00:34:19,968 and make us dance behind bars 635 00:34:19,970 --> 00:34:23,705 just like we make bears dance in zoos today. 636 00:34:23,707 --> 00:34:25,908 But at the present time, 637 00:34:25,910 --> 00:34:29,211 none of these technologies are ready for prime time. 638 00:34:29,213 --> 00:34:32,748 We simply don't have an operating quantum computer. 639 00:34:32,750 --> 00:34:37,586 The world's record for a quantum computer calculation is -- 640 00:34:37,588 --> 00:34:38,720 ta-da -- 641 00:34:38,722 --> 00:34:42,257 3 times 5 is 15. 642 00:34:42,259 --> 00:34:45,194 We sometimes forget that computers and robots, 643 00:34:45,196 --> 00:34:49,331 no matter how advanced they are, are adding machines. 644 00:34:49,333 --> 00:34:50,532 But that doesn't mean 645 00:34:50,534 --> 00:34:53,936 they have creativity, imagination, initiative. 646 00:34:53,938 --> 00:34:56,305 It doesn't mean they understand human values. 647 00:34:56,307 --> 00:34:59,441 It doesn't mean that they can make leaps of logic like we can. 648 00:34:59,443 --> 00:35:02,077 In other words, we have a long ways to go 649 00:35:02,079 --> 00:35:04,379 before we can begin to approximate 650 00:35:04,381 --> 00:35:08,016 the real thinking process that takes place in a human being. 651 00:35:08,018 --> 00:35:12,387 Freeman: We're safe from becoming slaves to quantum intelligence... 652 00:35:12,389 --> 00:35:13,922 For the time being. 653 00:35:13,924 --> 00:35:18,126 But this physicist envisions a different fate for mankind, 654 00:35:18,128 --> 00:35:22,564 one where the lines between artificial and biological life 655 00:35:22,566 --> 00:35:23,832 will blur 656 00:35:23,834 --> 00:35:27,402 and immortality will become reality, 657 00:35:27,404 --> 00:35:29,271 not just for the living... 658 00:35:29,273 --> 00:35:32,774 But also for the dead. 659 00:35:36,800 --> 00:35:38,767 We're taught to think of science and religion 660 00:35:38,769 --> 00:35:40,436 as separate truths. 661 00:35:40,438 --> 00:35:43,672 Albert Einstein didn't believe that. 662 00:35:43,674 --> 00:35:47,576 He said, "Science without religion is lame. 663 00:35:47,578 --> 00:35:50,846 Religion without science is blind." 664 00:35:50,848 --> 00:35:54,149 The secret to achieving immortality 665 00:35:54,151 --> 00:35:58,120 could require the fusion of humanity and God 666 00:35:58,122 --> 00:36:01,690 into an everlasting cosmic computer. 667 00:36:01,692 --> 00:36:05,694 Few people think further into the future than Frank Tipler, 668 00:36:05,696 --> 00:36:07,296 a mathematical physicist 669 00:36:07,298 --> 00:36:10,332 at Tulane university in New Orleans. 670 00:36:10,334 --> 00:36:13,802 Frank predicts that, at some point in our evolution, 671 00:36:13,804 --> 00:36:16,505 something truly remarkable will happen. 672 00:36:16,507 --> 00:36:22,778 Humanity, the Universe, and God will unite -- 673 00:36:22,780 --> 00:36:27,182 a moment he calls the omega point. 674 00:36:27,184 --> 00:36:31,954 Tipler: The omega point is the very end of the Universe. 675 00:36:31,956 --> 00:36:36,024 In the process, mankind, or, more precisely, our descendants, 676 00:36:36,026 --> 00:36:38,327 will expand out from this planet 677 00:36:38,329 --> 00:36:43,031 and ultimately engulf the entire Universe. 678 00:36:43,033 --> 00:36:47,302 As our descendants are moving into this final state, 679 00:36:47,304 --> 00:36:51,573 their knowledge and their power and their computer capacity 680 00:36:51,575 --> 00:36:55,244 is increasing without limit. 681 00:36:55,246 --> 00:36:56,645 The laws of physics 682 00:36:56,647 --> 00:36:59,681 allow a process that will convert matter -- 683 00:36:59,683 --> 00:37:05,554 stones of this graveyard, for instance -- into pure energy. 684 00:37:05,556 --> 00:37:08,323 That will be the ultimate energy source, 685 00:37:08,325 --> 00:37:11,860 which our descendants will use and gain control of it. 686 00:37:11,862 --> 00:37:14,963 Freeman: At the omega point, Frank argues, 687 00:37:14,965 --> 00:37:19,101 our descendants will be capable of doing anything. 688 00:37:19,103 --> 00:37:23,739 And with infinite power, they will create a cosmic computer 689 00:37:23,741 --> 00:37:25,641 and reconstruct in a simulation 690 00:37:25,643 --> 00:37:27,876 everything that has ever happened 691 00:37:27,878 --> 00:37:30,112 in the history of the Universe. 692 00:37:30,114 --> 00:37:33,949 Now, from the point of view of the beings in the far future, 693 00:37:33,951 --> 00:37:37,986 we will be their alternate ancestor as rational beings 694 00:37:37,988 --> 00:37:42,024 so they will be interested in what we were, what we were like. 695 00:37:42,026 --> 00:37:45,494 As a consequence, every man, woman, and child 696 00:37:45,496 --> 00:37:47,696 will be brought back into existence. 697 00:37:47,698 --> 00:37:50,899 It will be just like you are brought back with your body 698 00:37:50,901 --> 00:37:54,870 into a reconstructed earth just like we now live on. 699 00:37:54,872 --> 00:37:58,307 It will be different in one crucial respect. 700 00:37:58,309 --> 00:37:59,741 We will be resurrected, 701 00:37:59,743 --> 00:38:02,744 but we will never have to go through death again. 702 00:38:02,746 --> 00:38:05,347 Freeman: Frank claims the laws of physics 703 00:38:05,349 --> 00:38:08,650 not only permit this type of immortality -- 704 00:38:08,652 --> 00:38:11,420 they actually require it to happen. 705 00:38:11,422 --> 00:38:14,022 Tipler: Second law of thermodynamics says 706 00:38:14,024 --> 00:38:18,760 the complexity of the Universe at the most fundamental level 707 00:38:18,762 --> 00:38:21,029 is increasing without limit. 708 00:38:21,031 --> 00:38:22,931 I conclude 709 00:38:22,933 --> 00:38:25,868 that the validity of the second law of thermodynamics, 710 00:38:25,870 --> 00:38:28,470 throughout all of time, 711 00:38:28,472 --> 00:38:30,873 actually requires life 712 00:38:30,875 --> 00:38:35,310 to come into existence to gain control of the Universe. 713 00:38:35,312 --> 00:38:39,014 Freeman: Whether immortality comes in billions of years 714 00:38:39,016 --> 00:38:41,516 or whether it comes this century, 715 00:38:41,518 --> 00:38:46,021 the conquest of death will transform our civilization -- 716 00:38:46,023 --> 00:38:50,692 the way we live, the way we work, the way we love. 717 00:38:50,694 --> 00:38:53,996 Maybe the question is not "Can we live forever?" 718 00:38:53,998 --> 00:38:56,265 But "Should we?" 719 00:38:59,936 --> 00:39:01,536 Alexander Rose 720 00:39:01,538 --> 00:39:04,973 is the executive director of the Long Now Foundation, 721 00:39:04,975 --> 00:39:07,843 an organization whose main focus 722 00:39:07,845 --> 00:39:11,947 is the building of an unusual timepiece. 723 00:39:11,949 --> 00:39:16,418 It's called the clock of the long now, 724 00:39:16,420 --> 00:39:21,523 and it's designed to tick for 10,000 years. 725 00:39:21,525 --> 00:39:24,493 Rose: We built the 10,000-year clock 726 00:39:24,495 --> 00:39:27,596 to give people a different perspective 727 00:39:27,598 --> 00:39:29,498 of the really long term. 728 00:39:29,500 --> 00:39:31,900 If you believe that medical science or other things 729 00:39:31,902 --> 00:39:33,802 are going to increase human longevity, 730 00:39:33,804 --> 00:39:36,838 then the way that you would approach the world 731 00:39:36,840 --> 00:39:38,607 would be very, very differently -- 732 00:39:38,609 --> 00:39:41,476 just the same way that if we're designing a 10,000-year clock 733 00:39:41,478 --> 00:39:44,680 instead of a clock that just has to last for 10 years, 734 00:39:44,682 --> 00:39:47,749 we have approached this design problem very differently. 735 00:39:47,751 --> 00:39:50,886 And we have to be responsible over those next 10,000 years 736 00:39:50,888 --> 00:39:51,920 for our clock. 737 00:39:51,922 --> 00:39:54,089 Freeman: 10,000 years in the past, 738 00:39:54,091 --> 00:39:57,192 we were still living in the Stone Age. 739 00:39:57,194 --> 00:39:59,261 Flash forward the same period, 740 00:39:59,263 --> 00:40:01,897 and our civilization and technology 741 00:40:01,899 --> 00:40:04,700 will be unrecognizable. 742 00:40:04,702 --> 00:40:07,102 We realize in designing a 10,000-year clock 743 00:40:07,104 --> 00:40:10,973 that the most durable design is likely the simplest. 744 00:40:10,975 --> 00:40:15,210 Freeman: The clock of the long now will be all mechanical. 745 00:40:15,212 --> 00:40:18,313 Power in the clock will come from the force of gravity. 746 00:40:18,315 --> 00:40:23,385 A weight-driven system will turn a threaded bar. 747 00:40:23,387 --> 00:40:25,287 And the clock will keep time 748 00:40:25,289 --> 00:40:28,090 in both the short term, with the pendulum, 749 00:40:28,092 --> 00:40:30,826 and in the long term, through a solar synchronizer. 750 00:40:30,828 --> 00:40:35,330 This device may or may not last for 10 millennia, 751 00:40:35,332 --> 00:40:38,934 but that's not really Alexander's point. 752 00:40:38,936 --> 00:40:42,337 He wants to make us imagine what we will be like 753 00:40:42,339 --> 00:40:45,674 10,000 years from now. 754 00:40:45,676 --> 00:40:47,776 Rose: As soon as you see that 10,000-year clock 755 00:40:47,778 --> 00:40:50,312 and you visit it, the conversations that you have 756 00:40:50,314 --> 00:40:52,214 around whether or not humans will be there, 757 00:40:52,216 --> 00:40:54,683 the shapes of the hands of the people that might wind it -- 758 00:40:54,685 --> 00:40:56,351 "Are they gonna be the same as ours?" 759 00:40:56,353 --> 00:40:57,652 "Are they gonna be different?" 760 00:40:57,654 --> 00:41:00,422 Those kind of conversations immediately allow you 761 00:41:00,424 --> 00:41:03,291 to take responsibility for that kind of time span, 762 00:41:03,293 --> 00:41:05,494 and that's the hope with this clock. 763 00:41:05,496 --> 00:41:10,632 Freeman: 10,000 years from now, human beings may be immortal. 764 00:41:10,634 --> 00:41:12,067 Even if they're not, 765 00:41:12,069 --> 00:41:15,737 their life-spans will surely be vastly longer than ours. 766 00:41:15,739 --> 00:41:18,974 But it won't be just our bodies that will change. 767 00:41:18,976 --> 00:41:23,512 What it means to be human will be different. 768 00:41:23,514 --> 00:41:26,048 If you think about all the human values, 769 00:41:26,050 --> 00:41:27,549 quite a lot of them come 770 00:41:27,551 --> 00:41:30,452 from the fact that we know that life is finite. 771 00:41:30,454 --> 00:41:34,456 If you think, "How do I feel towards that person?" 772 00:41:34,458 --> 00:41:35,957 The fact that you know 773 00:41:35,959 --> 00:41:38,960 that the person is not gonna be there one day 774 00:41:38,962 --> 00:41:42,497 probably makes your emotions far stronger in some sense 775 00:41:42,499 --> 00:41:44,433 than other ways they would be. 776 00:41:44,435 --> 00:41:47,602 So this could all change, and maybe some of these things 777 00:41:47,604 --> 00:41:50,505 would even disappear from the human race 778 00:41:50,507 --> 00:41:52,908 if we simply knew we could live forever. 779 00:41:52,910 --> 00:41:55,877 Rose: What happens to marriage and relationships 780 00:41:55,879 --> 00:41:58,747 if our life-spans grow to 1,000 years or more? 781 00:41:58,749 --> 00:42:00,082 Right now, 782 00:42:00,084 --> 00:42:02,784 half of us get divorced just in our short lifetimes. 783 00:42:02,786 --> 00:42:04,786 But if we lived for 1,000 years, 784 00:42:04,788 --> 00:42:08,090 who knows how many times you might get married? 785 00:42:08,092 --> 00:42:10,659 I don't think that I would be able to live forever. 786 00:42:10,661 --> 00:42:12,594 I think my wife would kill me first. 787 00:42:12,596 --> 00:42:15,130 Freeman: Whether we like it or not, 788 00:42:15,132 --> 00:42:18,066 more and more scientists believe we will one day live 789 00:42:18,068 --> 00:42:22,337 in a world without age, disease, and death... 790 00:42:22,339 --> 00:42:26,475 That we'll revel in the joys and wonders of endless life 791 00:42:26,477 --> 00:42:30,479 and that we'll just have to learn to cope 792 00:42:30,481 --> 00:42:34,950 with the consequences of living forever. 793 00:42:34,952 --> 00:42:40,689 Mythology says that the Gods envy our mortality. 794 00:42:40,691 --> 00:42:42,324 Our mortality 795 00:42:42,326 --> 00:42:46,261 is what makes life precious and something to be savored. 796 00:42:46,263 --> 00:42:49,364 Driven by the pressure of time to achieve greatness, 797 00:42:49,366 --> 00:42:53,602 it may be our mortality that gives us our humanity. 798 00:42:53,604 --> 00:42:56,004 But as long as we are mortal, 799 00:42:56,006 --> 00:42:59,975 we'll never stop dreaming of life everlasting. 800 00:42:59,977 --> 00:43:04,179 That, too, is what makes us human. 801 00:43:04,253 --> 00:43:08,253 == sync, corrected by elderman ==65655

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