All language subtitles for Living.Proof.2008.1080p.WEBRip.x265-RARBG

Dr. Slamon? Hi.
Hello.

It's Jamie MacGraw.
Work-Study sent me.

Oh! My student assistant.
Right, right.

I'm right up here
on the left.

Okay.
Come on in.

What are you,
biology, chem?

No. English lit.

You're not
a science major?

No.

No offense, uh...
Jamie.

Jamie. Right. But I'm doing
scientific research here,

and I kind of need
an assistant who
understands what I do.

Well, this wasn't my
first choice, either,

and no science majors
wanted this job.

What

No.

Well, tell me you at least
read science fiction.

Mmm...

Dr. Slamon's office,
I mean, lab.

Jamie. Oh!
Nice to meet you,
too, Mrs. Slamon.

Hold on.

Here.
Hi.

No, I didn't forget.
6:30 at the latest, right?

Okay. Me, too.
Bye-bye.

Could you hand me that
splicer over there, please?

Um...

No, no, no, to the left,
to the left.
Left, left, left, left.

Right there.
Thank you very much.

Well, thanks anyway.

You know what?

I don't really need
a science major.

I just need someone
to handle my calls,
do the paperwork.

Whatever it takes
so I can concentrate
on my patients and HER-2.

HER

Yeah, it's a growth
gene I'm using to

try and create a drug
to treat breast cancer.

Oh! Like chemo?

No. No, no, no.
It's nothing like chemo.

See, chemotherapy works
on the principle
of killing cancer cells,

and almost the patient,

with poison and just
hoping the new cells
grow back cancer-free.

That doesn't make
sense to me.

What I'm trying to do
is something that's
never been done before.

Take a sort of
super-protein from the body

and target the bad cells
and turn them off
like a light switch.

It won't cure the cancer,
but it'll shut it off,
which is almost as good.

That sounds really...

Crazy. Right, I know.

Everyone says that,
but it's not.

If we can learn how to
shut the bad cells off,

that will lead us
to a cure.

And, just so you know,

I'm not gonna remember
your birthday, or
National Assistants' Day.

Not because I don't try
or because I don't want to.
Hold this, please.

I just won't.

And I'm gonna constantly
be after you to stay late
and come early,

even if I can't
pay you on time.

You are trying to talk me
into this job, right?

Yes. But I want to be clear.

200,000 women a year
are diagnosed
with breast cancer.

Getting HER-2 to work could
save a lot of those lives.

200,000 a year?

Oh!
Grams is here!

Good morning, Samuel.

You're going to
sleep in my room.

Well. It's a very small
bed for two people.

I'm going to sleep
with my mom.

Hi, Mom.
Thank you so much
for coming.

Of course, dear.

Although, why Charlie
chose to go on the road
this particular week,

and why you wouldn't come
and stay at my house
remains a mystery.

You do still have
a room there, you know?

I want to be home.
So does Sam.

Could we not go
over this again?

I was merely
pointing out that

it would be
less stressful
for all of us,

you, especially,
to be in a house

that has adequate
space and amenities,

like air conditioning.

This will be fine.

I'll just put
my things away.

And you, young man,
should do the same with
that bicycle of yours.

Why does she have
to be here?

Because she's my mother
and your grandmother.

And next to you and Daddy,
she's all I've got.

Oh, Kate, I love that
you put that up there.

KATE: It's official.
Oh!

Your own shop
on Melrose Avenue.

I can't believe it.
I'm a real designer.

You've been a designer.
The only difference is that

now you're a designer
with overhead.

Oh! Chartreuse,
what was I thinking?

Kate, if nobody
buys anything...

That's not gonna happen.

So, get over here
and make a toast.

We got to
commemorate the day.

You don't miss a beat.
Champagne?

Mmm-hmm.
A good year, too.

What are we going to
toast to? Let's see...

Mmm. I got it.

To good friends...

Yes.

...hard work

and to kicking
some retail ass.

Amen, sister.

Mmm.

It's official.
You make the best cup
of coffee in the world.

Yeah. You say
that every day.

I mean it every day.

You decided
about summer school?

Someone else
can teach it.

I'm going to spend
the summer sleeping in
and getting fat.

And cleaning out
the sun room
for my studio.

Finally. With your talent
you should be making art
instead of teaching it.

Lilly. What are you
doing here?

I need an excuse
to say hello?

This is your lab?
This little room?

I know. The janitor's
closet's bigger.

But the chances
of him curing cancer
are slim to none,

so I got him there.

Lilly Tartikoff, old friend,
Jamie MacGraw, new assistant.

Hi.
Hello.

How's Brandon?
Is he okay?

A star, who shall remain
nameless, is giving him
indigestion,

and the Dodgers
are in a slump.

But other than that,
he's fine.

How's Donna?
I owe her a call.

She's good.
When you call her,
say hi for me.

Poor Donna.

At least I can tell
my husband
he has to come home.

It's not like
he's curing cancer.

Here, don't say
I never gave you anything.

That is every episode
of Hill Street Blues,

which you always miss
because you're always here.

You've got to
be kidding me.

Being married
to the president of NBC
Entertainment has its perks.

You didn't have
to do this.
Thank you so much.

You saved my husband's life.
Thank you.

I'm sorry,
but I promised Donna
I would get him out on time,

and we still have
our rounds.

Good for you.
Keep on him.

And you, lives
need to be saved.
Get back to work.

Bye.
JAMIE: Bye.

Bye, Lilly. Thank you.

All right. You heard her,
let's get back to work.

I'm sorry. I was trying
not to wake you.

Oh, that was thoughtful.

But I couldn't sleep
after you promised to be
home five hours ago

and never showed up.

The specimen
refrigerator
broke and...

I am so not done.

I'm sorry.

An hour-long recital.

I reminded you today,
yesterday. I even put
Jamie on the case.

I did everything but
drive you there myself.

I had to do the
transfer myself.

Your daughter was
expecting you.

There was no one
I could call.

It's my work.
If anything happened,

I'd have to start
all over.
Start all over. I know.

I knew when I married
you what I was in for.

But they just want
their daddy there.

Not every time.
But sometimes.

I'll make it up
to her on Sunday.

That would be good.

Okay. I'm officially
over it.

You're sure?

Yeah.

Because you know
I'm going to kiss you now.

Mmm.

You smell good.

Oh, you, wow,
not so good.

So, how was she?

Honestly, she was the
best sunflower I think
I've ever seen.

You know why?
She gets that from you.

You weren't really
waiting up for me,
were you?

No, I fell asleep reading.

And no offense,
but I really
want to get back.

Then you won't mind
if I go for a run?

'Cause I'm not
gonna have time
in the morning.

Yeah. That's not
gonna happen.

So not happening?
Uh-uh!

Okay. I didn't want
to run anyway.

You've done that
a thousand times.

Well, that's what
science is.

JAMIE: But what exactly
are you doing?

I showed you the plan.

Uh, no. You didn't.

That's the plan.
Step one is discovery.

That's a
one-in-a-million shot

linking the HER-2 protein
with cell growth
in breast tissue.

I did that right
here in this lab.

Step two is to create
a drug from HER-2.

That's where
we are right now.

I'm doing some of
that work right here.

And they're doing
the rest up at Genentech.

And that's a drug company.
Right.

It's a biotech company
up in the Bay Area.

And biotech is...

Is looking for medicines
based on molecular biology.

Step three is
the Mouse Protein Experiment.

I'll explain more
about that when we get
a little bit closer.

Steps four, five and six
are the FDA
clinical drug trials,

to see if the drug works
and how well it works.

Which would lead
us to Step seven,

the Holy Grail,
our drug is approved.

DENNY: Hey, Blake. Blake.

You're not going to
believe this new data.

I was trying to catch you
before you got on the plane.

I've got some bad news.

Okay. How much
are they cutting
our budget this time?

I'm sorry, Denny.

The board has decided
not to continue with HER-2.

You did not
just say that.

They think cancer research
just carries too much risk.

What? They're just
deciding that now?

We spent six years
on this!

Yeah. And they've been
dragging their feet
every step of the way.

We're getting close.
You know we are.
The board knows it, too.

Try to see
their perspective.

Continuing will cost
millions of dollars and
the drug might not work.

But it might!

Take a look
at the new data.

I'm a believer
based on the old data.

It's a hard pill, Denny,
but you got to swallow.

We can't stop.

Not until we know
what we have.

Dinner's ready.
I need to finish.

What's going on?

You haven't said
two words all day.

Genentech is
dropping HER-2.

So you'll take it to
another drug company.

I can't.

Genentech owns the rights.

But you developed
the drug.

It doesn't matter, okay?

I did it using
one of their genes,
so it belongs to them.

Honey, you have been
in this position before

and you always
work it out.

Really not in the mood
to be cheered up right now.
Okay?

I don't care.

I don't. It's Sunday,
the one day of
the week that's ours.

And on Sunday,
I don't care about cancer,
HER-2 or Genentech.

Just our family.

That was our deal
from day one.

So, stop feeling
sorry for yourself,

put a smile on
that cute face, and
come in for dinner.

Daddy!

You're just in time for
the 10:00 tune-up special.

Well, if I were staying,
I'd take you up on it.

You should stay.
It's his first birthday.

We can have another cake
at dinner tomorrow.

A yard full of
screaming children
is not my cup of tea.

Come on, it'll be fun.
I hardly get a chance
to see you.

Really? And that's
something you want?

Just as much as you do.

Um, if she's sleeping,
just let her.

Sleeping

She's tired.
Taking care of two boys
is a lot of work, you know.

You mean three.

Yeah.

Your film looks fine.
Lie down, please.

Lift your left arm.

Have you noticed any lumps
or anything unusual
since your last visit?

No.
Right arm.

Are you doing your
weekly self

Like clockwork.
Good.

You're fine.
See you in six months.

Wham, bam, thank you,
ma'am, to you, too.

Whoa, whoa!

I'm sorry.

I've been paging you
and paging you.

You need to jump
on a plane.

Blake called and
he said it's urgent.

Good urgent?
Bad urgent?

He wouldn't say.
But it's gotta be good.

You're right.
I've got the smallest
budget at UCLA,

the smallest lab
and no Genentech money.

How could it be worse?

It's gonna be good.
You're due.

See you soon.

I don't believe it!

How in the world
did you get the board
to change its mind?

Oh, simple.
Just committed
career suicide.

You committed what?

I can devote 20% of my time
to any project I want.

I chose HER-2.

It did not go over
very well, believe me.

And if we screw this up,
I'm pretty sure
I'll be free to leave.

We won't screw it up.

God help me for
believing in you and this.

I'd sleep a lot better
at night if I didn't.

But listen, you're going to
have to take that lead foot
of yours off the gas.

We're going to have
a lot less lab time
and money.

Got it.
I'm serious.

However slow it's going now,
ratchet that down by half.

You know what?
It really doesn't matter.

I mean, we're still
in the game, right?

Which is more than
we could say two days ago.

Realistically, though,
how soon till we get
a bigger budget?

Get out. Get out.

Put the globe back
and get out.

So, did you decide
on the teaching job?

I'm too busy around here.
The paycheck would have
been nice, though.

Come on.
You're a doctor's wife.

A university doctor.

He gets
a teacher's paycheck.
I'm not complaining.

It's just we're going to
have to win the lottery when
it comes time for college.

Well, if you do win and
you need a bad influence,
I know just the stores.

Maybe one spree.

I'd give the rest to
Denny for his research.

No. Let Genentech
pay for that.

I can't count on them.

They're constantly
threatening to cut
his funding.

But he's trying
to cure cancer.

Who wouldn't
support that?

Well, if they get behind
the drug and it fails,

it could bankrupt
the whole company.
They're terrified.

Well, he never said
anything to me.

Oh, you know Denny.

He could break his arm
and you wouldn't know it.

He's really suffering.

Don't say anything.

I won't.

I've made a decision.

I'm going to raise money
for your research.

You're going to what?

Last night
I was sitting in my
Beverly Hills home,

with my wonderful husband
and my beautiful daughter,

and I was suddenly
overwhelmed with how
much I've been given.

I need to start
giving back.

And I'm going to
do it through you.

Very, very generous
of you, Lilly, but
I can't let you do that.

You need the money.

What, you're going to
cure cancer in here?

Lilly, the fact that
you would even think

about doing something
like that for me

means more
than I can say.

But I can't let you do that.
We're friends.

Are you kidding me?

You spent
I don't know how
many days and nights

away from Donna
and the kids
with Brandon's chemo

and helping me
get through it.

You saved him.

That makes us more
than friends, Denny.
We're family.

Yes. Which is why
I can't take your money.

It's not going
to be my money.
I'm going to raise it.

No.

No?

Look, Mr. "I Don't Care
if I Work in the Smallest
Lab in the Universe,"

I'm offering you money
for your research.

Now, if you don't want it,

I'll go find some other
deserving doctor who does.

Great. Now can we be done
with this conversation?

You absolutely stink
at accepting gifts.

Get over it!

You're this close
to losing HER-2

because some executives
are running scared.

Well, screw them.
The cavalry is here.

And you are going to
have your own money.

It's a promise.

Goodbye.

Oh, Brandon,
good to see you.

Hi.

Thank you very much.

Wow, Brandon
knows everyone.

Yes, and if he doesn't,
they know him.

But don't worry.
He'll be here
before the appetizers.

Is that an actor?

No. Better.
That's Ron Perelman.

Who?
Who?

He's one of the
richest men in America.

He owns Revlon.

I'll be back in two minutes.
Hopefully five.

Ron Perelman?

Yes?

We haven't officially met.
I'm Lilly Tartikoff.

So you're Lilly.
Is Brandon with you?

Almost. He's making
his way to the table.

I thought I would take
a minute to say hello.

Well, I'm glad you did.

These are my friends,
Peter and Bindy Hawn.

Lilly is on our
Products Advisory Board

and for the past two
years has been
sending me suggestions

for our ad campaign.

I used to be on that board.
But I don't recall

anyone ever sending
in a suggestion.

No one did.
Until Lilly.

Ask for my opinion,
you're going to get it.

I don't want
to take your time.

I wanted to ask a favor.

Of course.

Do you see the man
at that table there?

That's Dr. Dennis Slamon.

He's on the verge of
discovering something
very important.

It's a new kind of
drug for breast cancer.

And he needs money.

I'm sure he does,

but this is neither the time
nor the place to discuss it.

All I want
is a chance to tell
you about his work.

Call my office.
We'll discuss it
over lunch.

HER-2 is a growth gene
that controls the...

The...

Growth of cells.

Give me that.
Give it to me.

You don't need that.

Have you been here
the last two hours?
I'm not a memorizer.

Well, I don't want
you to memorize it.

I want you to
understand the concept.

Lilly, just be
conversational.

No one is more
conversational than I am.

But this is
the Revlon Foundation Board.

I get one shot
to get you more money.

I have to know
what I'm saying.

What you're saying
is very simple.

HER-2 is a gene
that controls
the growth of cells

in the breast tissue
of a third of all women.

And when those women
get breast cancer, it's
a very aggressive form.

And there's no
treatment available,
not even chemo.

So most of them
will die.

But if my drug
is successful,

it's going to offer
hope to these women
for the first time,

saving 40,000 lives a year.

That's enough to
fill the Rose Bowl
every other year.

Maybe if we gave you
some lipstick and a wig...

Lilly, you'll be fine.
Just tell them that I'm at
a make-it-or-break-it point.

If I had more money,
I could do the work
more quickly.

And if the drug works,
and I think it will,

we can get it approved
and on the market
five to six years faster.

Six years times 40,000
is a quarter million
lives potentially saved.

By Revlon.

Okay?

Okay. Once more,
from the top.

Andy, just the man
I wanted to see.

Denny, you know
I'm a believer in HER-2

and one of your
biggest supporters.

But the answer is no.

I haven't asked
you anything yet.

Have you ever asked me
for anything besides
more money?

Last week I asked
you about your dog.

Right before you hit me
up for more equipment.

Which I still need,
by the way.

CARL: And which
you're not going to get.

That's not your call,
Reinhart.

No. But I was in the meeting
and half the board members
agree with me.

An antibody approach
to cancer is never
going to work,

which makes HER-2
a terrific waste
of time and money.

So half of them
agree with me?

Wow. You see,
I thought it was
way less than that.

Thanks for the
encouragement, Carl.

We're late.
I promise next time
we'll talk, okay?

I'll be back on Thursday.

You're going to be glad
you kept this going.
You'll see.

You'll see.

Matt spilled his
cereal on Daddy.

I did not.

How many times
have I told you not
to play at the table?

JOEY LYN: A hundred.

Nuh-uh...

Could we please not fight?
Two hundred.

That was Lilly.

She just finished
the meeting at Revlon.

She did it.

You mean
Ron Perelman said yes?

Yeah.
Honey, that's great!

How much
is he gonna give you?

$50,000

Um...

No. $2.4 million.

It's the biggest amount
ever given to a researcher
without restrictions.

Oh, my God!
Oh, my God!

Wait. You're sure?

They're just
giving it to you?

There are no
strings attached?

Um, Lilly has to throw
a fundraiser every year
to make more.

More money?
More money.

Oh!

Nicole, sweetheart.
It's me. Mom.

Where's Charlie?

He's downstairs
taking care
of the paperwork.

The biopsy was malignant.

I know. I know, sweetheart.
But you're going to be fine.

Mom.

You just sleep now,
sweetheart.

And when you wake up,
we'll get good news.

Mom.

Don't worry. I'll be
right here waiting
for you. Charlie, too.

Lie down, please.
Lift your left arm.

Hello to you, too.

Sit up, please.

The film shows
a fast-growing mass
in your left breast.

From the looks of it,
it's cancer.

But I was just here
six months ago.

As I said,
it's fast-growing.

How old was your mother
when she was diagnosed?

30.
And you are?

30.

I'm referring you to
an oncologist, Dr. Banks.

Well, if it is cancer,
what are my options?

Mastectomy, radiation,
chemotherapy, whatever
Dr. Banks prescribes.

But that's what they
gave my mom 15 years ago
and she died.

They don't work
for everyone.

But they're still
the standard of care.

There's got to be
something else.

Not yet. Good luck.

Honey, come in here.

What's up, baby?

I found a lump
in my breast.

Are you sure?

Yes, it's cancer.

You don't know that.

Yes, I do.

WOMAN: Lilly, Lilly.

This is surreal.

I passed surreal
a long time ago.

Good to see you both.

Thank you for this.

Tonight is just
the beginning.

Hi.

Hi.
Hi.

Can you believe it?
Everybody came.

I've been sick to my stomach
for five months worrying
that they wouldn't.

You look beautiful.

You both look
like movie stars.

Thank you.

Okay. I've got
to work the room.

I will see you
at the table.

Great.
Okay.

Oh! And tonight is
making us $400,000 more,

so that ought to keep you
in test tubes a bit longer.

And get you a bigger lab.

Wow!

I'll see you. Hi.

I just got to say,
I'm really stoked
to be working here.

That's great.

When does
the HER

After we do the
Mouse Protein Test,

which we're waiting
for Genentech to approve.

Mouse protein?

HER-2 is a protein
and they grow it in mice

because it's illegal
to grow in humans.

And mouse protein
is the most
like human tissue.

So it adds another step,
because they have to test
to make sure it's safe.

What if Genentech says
you can't test it?

They won't.
I'll be back at 2:00.

Don't mind him.
We've just been waiting
to hear for six months.

If they say no,
then it's over.

Could you
go next door and get
the boys, please?

I was hoping we could
have a cup of tea.

Maybe in the backyard.
It's such a beautiful day.
Not too hot, not too cold.

Hmm?

Okay. That would be nice.

Excellent. You sit down.
I'll get it.

I'm sorry.

Don't be silly.

How hard is it to
make a pot of tea?

That you're gonna
lose someone again.

I am not losing you.

I think it would be
easier for everyone

if we just accept it
and enjoy the time
we have left.

Oh, yes,
by all means.

Let's take
the easy way out.

It's just your life
we're talking about.

Since when did I
raise a quitter?

I have stage-four
cancer, Mom.

We haven't run out
of doctors yet.

No, we haven't.

Just tell me we're
beyond the "K's," right?

Oh! We're well
into the "M's."

Okay, good.

I'm going to go
change and, uh...

Cream or lemon?

I think it's cream today.

I hate chemo.
I hate chemo.

WOMAN: Your mom's
on line two.

Hey, Mom, what's up?

Hey, what's up?

Um, I've been behind you
and Denny for a long time,

so I'm going to
ask you flat out.

Are we ready to take HER-2
to the next step?

100%.

Okay. I'm approving
the Mouse Protein study.

Call Slamon and give him
the go-ahead. Tell him
he needs to hurry.

Oh, uh, he'll be ready,
Andy. Believe me.

Hey, you okay?

My mother was just
diagnosed
with breast cancer.

I'm sorry.

Did you get Ricky
to sleep?

Mmm-hmm.

Listen to this.

"UCLA is looking
for volunteers with
advanced cancer

"to test
an experimental drug."

It says to call
a Dr. Slamon.

There's no harm
in calling.

You do qualify
for the study.

And I know your time
is very, very precious,

so I want to thank you
for giving a week of it
to me.

I'd be lying if I didn't
tell you I'm hoping for
a miracle.

Hope is a good thing.
I do it all the time.

I want you to remember
that this is only a test

to see if the drug that
was grown in mice can be
tolerated by people.

Now, that means
I can only give you
one dose.

But if it works
like I think it will,

it might give you
a little bit more time.

And we're talking about
the time you have left.

So I want you to
take a day or two
and think about it.

And whatever you decide,
is the right decision. Okay?

I don't need to
think about it.

Good morning, everyone.

Today is a historic day.

We're here to do
something that has
never been done before.

To inject a drug that
was grown in mouse
protein into people

to see if it's safe.

I have every faith
that it will not
harm you in any way.

And hopefully,
if the drug works
like I think it will,

it'll give you more time.

Good morning, Nicole.

Good morning.

Are you ready?

Yes.

Congratulations.
You just made history.

Good morning.
WOMAN: Good morning.

We've got a reaction.
Nicole Wilson.

DENNY: Miss Mouse Ears.

You just finished
the Mouse Protein Test
four months ago.

In corporate time
that's like five minutes.

Yeah. That's just
long enough for them
to forget about us.

We have to start
the Phase One Trial.
They have to say yes.

Truth? I think most of
them wish they'd never
heard of you or HER-2.

Yeah? Tell me
something I don't know.

Hello.
ANDY: Denny, nice to see you.

Unnecessary. We have
everything we need
to make our decision.

I just want to remind you
of a couple of things first.

HER-2 is the most
promising drug this
company has ever seen.

I stood right here and
I did something that has
never been done before.

I shrank a cancer tumor
with six drops of our drug.

No poison, no chemo.
Just the antibody.

Well, it's a big leap
from shrinking a tumor
in a dish

to curing cancer, Doctor.

This isn't a cure.

It's a treatment to
shrink cancer tumors
and make them inactive.

Which is better than
chemo and radiation

because it has
no side effects.

I wish we could know
without an official study
that the drug will work.

But if we test it
and have a bad result,

it will be the Interferon
disaster all over again.

It's the only cancer
drug we ever developed
and it almost ruined us.

You developed that
based on no hard evidence.

I have shown you real data.

Real data that
HER-2 can work.

We can't base our decision
just on the science.

We have a responsibility
to the company.

And spending millions
on HER-2

means we aren't
spending it on more
promising drugs.

When you put all
the pieces together,

the potential downside
is just too severe.

Well, clearly,
you don't have anyone
with cancer in your life.

How lucky for you.
Well, I do.

I speak to cancer patients
and their families every day,

and I hope for their sake
that one day there's a better
treatment out there

than the current
slash and burn that
exists at the moment!

When I was a kid,
I watched a doctor
save my father's life

and I knew in that
moment that I wanted
to do what he did

because when you save
someone's life, you're
not just saving them,

you're saving
everyone around them.

And now, when I look
into a woman's eyes

and tell her that
her cancer is terminal

and she tells me,
"What other treatments
are available?"

and I tell her,
"We don't have any,"

I know that we do.

MAN: But you don't know
HER-2 will work.

I do know! I know!

Don't throw
this chance away!

Maybe you've been sitting
behind a desk for too long.

Maybe I've been
on the front lines longer
than I should have,

but for God's sake,
don't forget who we are!

We're not businessmen.

We're doctors.

Approve the
Phase One Trial.

You guys are fast.

We could still
use some help.

I was working on
my masterpiece.

Hmm?

You look beautiful.

Not too bad for someone
who wasn't supposed to
make it till Christmas, huh?

Let's put this
right in the middle.

CHILD: Ooh! Like that.

That's us!

You look so pretty.

What are you doing?

Loving you.

But, Mom,
I've got soccer.

Mother's prerogative.

Ellie?

Hi. Do I know you?

I'm Josh.

Thank you.

Oh, I'm meeting
a friend.

Yeah, me.

Kate set us up.

Oh, gosh.

Look, I'm sorry.
I don't date.

You do eat?

Look, Josh...
We're here, so why not?

We'll eat fast.
We don't even
have to talk.

DR. BROWN: The cancer is back.

I'm scheduling another
round of chemotherapy.

No.

No more chemo.
We've decided.

It's a quality
of life issue.

I understand.
I'm very sorry.

There is an outside chance.

A colleague is
going to be testing
an experimental drug.

I'd like to send
your slides.

Whatever.

Hey. I've been
waiting for you.

I got some news.
The board voted yes.

We're moving
to Phase One?

Yeah, but there's trouble.

They put Reinhart
in charge.

Reinhart?

Why? He doesn't even
believe in HER-2.

But you know what,
a go is a go, so...

Let me finish, Denny.

He's bringing in these
so-called "thought leaders"
to head the study.

He's not including you.

But it's my study.

It's Genentech's study
and they put Reinhart
in charge.

I'm sorry.
I went to bat for you,
but it's his call.

Whoa, whoa, whoa!
Hang on a second.

You have to
change his mind.

They want superstars,

breast cancer specialists
who've run these big clinical
tests before. You haven't.

Come on. You need me.

This isn't just me
protecting my turf here.

This is me protecting
everything we've worked for.

There are three
arms of the study.

San Francisco,
New York, Los Angeles.

I'll go back to him,
see if I can get him
to give you LA.

I've already set up
a network of doctors

who're gonna refer
their patients to me,
so tell him that.

Keep screening
for participants.

I'll see what I can do.

Hello.
Barbara Bradfield?

Yes.
Yes, this is
Dr. Slamon at UCLA.

I'd like to talk
to you about joining
the HER-2 Trial.

What's HER

It's an experimental
drug. Dr. Brown
sent me your slides.

Right.

Thanks, but we're leaving
in the morning for Mexico.

I'm trying a food cure.

All due respect...
I'm not expecting a cure,

just some quality
time with my family.

Ms. Bradfield, if you'd
just delay your trip
for a day I think I can...

Does this trial
involve chemo?

Some, yes.

I'm not interested.

I refuse to die bald
and throwing up.

Good luck with your study.

Good luck to you, too.

Slamon.
You're back in.

LA is yours.
Reinhardt signed off?

Yeah. Now, go home
and get some rest.
You're going to need it.

Yes! Yes!

Once again,
Blake saves the day.

Oh, God.

I owe him big time.

Hmm.

How was your day?

Good.

Did you
find anyone?

One woman, best candidate
I've ever seen.

She's not
interested, though.

Going to Mexico
for a food cure.

There's a misnomer for you.

Did you talk to her?

As much as I could.
She's looking at
the end of her life,

so how she spends
that time is her call.

But, you know, I can't get
over the feeling I might be
able to help her.

And selfishly,
it's bad for the study
because I get 15 women

and I need to
make them all count.
So, I don't know.

Hey.

It's not always
gonna be like this,
these crazy hours.

Yes, it will.
But that's okay.

We just miss you.

Hello?

Hello, Barbara,
this is Dr. Slamon.

I'm sorry to be calling
this early. Barbara,
don't go to Mexico.

It's a death sentence.

I think I can
save your life.

* The moment I wake up

* Before I put on my makeup

* I say a little prayer
for you

* While combing my hair now

* And wondering
what dress to wear now

* I say a little prayer
for you

* Forever, forever,
you'll stay in my heart

* And I will love you

* Forever and ever,
we never will part

* Oh, how I love you

* Together, together,
that's how it must be

* To live without you

* Would only mean
heartbreak for me

* I run for the bus, dear

* While riding,
I think of us, dear

* I say a little prayer
for you

* At work,
I just take time

* And all through
my coffee-break time

* I say a little prayer
for you

* Forever, forever,
you'll stay in my heart

* And I will love you

* Forever and ever,
we never will part

* Oh, how I love you

* Together, together,
that's how it must be... *

They're all here.
All 15?

All 15. So, as we say
in show business,

break a leg.

DENNY: I'll see
you out there.

Oh! No. I have
another ball to plan.

You can take this from here.

Hey, Lilly.
I just wanted to say,

you know, without you,
this would...

Thank you.
I really mean it.
Thank you so much.

Good morning.

ALL: Good morning.

Welcome to the
Phase One kickoff party.

I'm very happy
to see all of you.

Not as happy as
we are to see you.

So, the drug you'll be
taking finally has a name,

Herceptin, which is
a combination of "Her"
from HER-2,

and "ceptin" from intercept,
which is what the drug
is designed to do,

to intercept growth
signals from reaching
the cancer cells

so they don't grow.
It's pretty simple
when you think about it.

Now, for the next
three months,

we'll be meeting here
every Tuesday at 9:00

for the infusion
and a checkup to
monitor your progress.

First two weeks, you'll
be receiving cisplatin,

a traditional
chemotherapy drug.

Every third week,
you'll get the Herceptin.

Now, since cisplatin
is a chemotherapy,

you'll have the traditional
side effects like fatigue
and nausea.

But on the weeks you
receive the Herceptin,
you'll feel great.

No side effects.

Finally, I want
to thank all of you
so much for coming here.

I appreciate your
hope and your belief
and your sacrifice.

Thank you.

I don't take that lightly.

Okay, any questions
before we begin?

Yeah, I do. Just one.

I hope everybody
here is hungry.

I know. The baker was gay,
so he hadn't seen boobs
in a while.

My nipples aren't
black like that.
Well, they're not.

* I say a little prayer
for you

* Forever, forever,
you'll stay in my heart

* And I will love you

* Forever and ever,
we never will part

* Oh, how I love you

* Together, together,
that's how it must be

* To live without you

* Would only mean
heartbreak for me *

ELIZABETH: Dr. Slamon.

I'm late for a consult.
You'll have to call my office.

Please. I drove
three hours to see you.

You'll have to make
an appointment.
I'm sorry.

My daughter participated in
the Mouse Protein Experiment,

Nicole Wilson?

Nicole, right.
Miss Mouse Ears.
She was the very first one.

Yes, exactly. Well,
her doctor told us you're
testing your new drug.

Right.
I'd like you to include her.

Believe me, I would
if I could, but she just
doesn't meet the criteria.

Well, nonsense.
She's a perfect candidate.

One shot kept her
alive for two years.

I'm sorry, Miss...
Aldredge.

Ms. Aldredge, right.
But the eligibility
requirements are very strict.

Well, then don't
put her in it.

Just give her the drug.

The FDA accounts
for every dose.
I'm very sorry.

My daughter is dying!

You have the power
to save her.

I don't.

I'm sorry, Mrs. Aldredge.
I do understand what you're
going through, but...

Have you lost
a child, Dr. Slamon?

Then don't presume to know
what I'm going through.

I promised my husband
as he lay dying

that I would take care
of our little girl.

For 24 years,
I have kept that promise,

and you will not
stand in my way
of keeping it now.

I can't help you.

Then get your superior
out here immediately.

There is no superior.

It's my study and I
don't have a choice.

If I break the rules,
they're going
to shut it down.

She's only 28.
She has two little boys.

She's all I've got,
Dr. Slamon.

Please don't
take her from me.

Please help me.
I can't lose her, too.

MAN: Dr. Slamon,
we need you right now, sir.

I'm very sorry.

Hey.

Hi, Daddy.

Hi.

Will you show me
that picture that
you drew for me?

I just really
want to see it.

Okay, Daddy.

You know, Barbara,
maybe this week
will be better.

Maybe the chemo won't
make you so sick.

Well, that would be nice,
but I don't think
it's in the cards.

Hey. You never know.

If I could just get home,
I wouldn't care.

Really? You don't like
puking your guts out into
your purse at the mall?

Must you be so graphic?

Well, I'm just being real.

I mean, that's really
what it is, right?

I mean, nothing's
more real than this,
this and puking.

And it really does just
cut through all the crap.

Yeah, well, next week
will be better.

We get the Herceptin.
No side effects.

Yay!

No, I am so ready.

Do you hear that, cancer?

You're going down.

You make this
all worthwhile.

Sorry.

Hold on a sec.

What? Well,
what are you doing?

It's been months.
I want to see you.

You want to see a scar?
You're a freak.

I love every inch of you,
including the breast
that isn't there.

Sex with me in the dark,

or sex by yourself
with the light on,
your choice.

How about a flashlight?

Come here.
Come here.

Does that hurt?
No.

I just, I don't know,
like looking at it.

Just reminds you
that you're sick.

I don't need a stinking tumor
to remind me that I'm sick.

Let's think good
thoughts today, Tish.

Positive energy
creates healing.

Wow. Is that what
I've been doing wrong
my whole life?

Tina, do you have
an herb for that with
some aromatherapy?

No, but we could do
some guided meditation.

That's just too
complicated for me.

Good morning.

ALL: Good morning.

Okay, so after
two weeks of chemo,

who's ready for their
first dose of Herceptin?

ALL: I am!
Me!

Okay. All right,
let's start with you, Sally.

Sally?

How's that cough?

It's almost gone.

That's good.

It's yellow.

All right.

I'm gonna get
more than you.

Hey, Dr. Slamon.
It's Fran Visco,

President of the National
Breast Cancer Coalition.

Yeah, I remember you.
You gave me a grant.

You were one of the very few.
Hey, do you mind walking?

I have a patient.
Oh, not at all.

Wow, you have
a good memory.

That was over
eight years ago.

You know, I've been
getting a lot of calls,

and I know you can't
really speak about it,
but how's Phase One going?

A lot of calls?

Yeah, the breast
cancer community
is very tight-knit,

and so they talk.

Off the record,
it's going well.

So there will be
a Phase Two?

Off the record, yes.

Good. Before you start
planning Phase Three,
call me.

You're gonna need
a perspective that
those scientists

who haven't been
through that cancer mill
don't have themselves.

Thank you, Fran.
And I will call you.

So, I bought this to
boost our immune systems.

You mix it once
a day in hot water,

and you drink it down,
just like tea.

What is it?
Dried sea horses.

Sally's late again.

Forget the cancer.
This'll kill me right here.

You know,
I know I'm always
joking with you,

but I swear to God,
your tumor has shrunk.

It has, hasn't it?
It is, right?
It has.

Let me see.
Let me see.

Look.

Oh, my God.
It's shrunk!

Now, Tina, I know
you didn't have time
to leave the hospital

and go find some sea horses.
What is this?

I mean, that came out
of the back of a dog.

No, it did.

Sally passed away
this morning.

Not from the drug,
but as a result of
her advanced cancer.

Carol will be in
to get you started.

I'm all right.

It wasn't your fault.

Her death, no.

What happens next,
though, that's all me.

What's all you?

I put them all in one room,
so they wouldn't feel alone.

Now they'll know
when one of them dies.

Great planning.

You couldn't have known.

But I should have.

Every single one of them
has stage-four cancer.

Some of them are
lucky to be alive.

I chose the room,
the chairs, the program.

I just spent so much time
trying to get it right.

You didn't know.
Next time you will.

Tell that to the women
who are looking
at the empty chair.

Kate! Turn down
the music.

What are you
doing here?

Oh.

I was in
the neighborhood,

thought I'd fall by,
see if you want to go
to Vegas this weekend.

And while we're there,

get married.

Ellie.

Josh.

I told you,
marriage is about
happily ever after,

and I don't know that
that applies to me.

Maybe the cancer's gone.

Not the cancer, my cancer.
And, yes, it's gone,

but it can come back.

If it does,
we'll deal with it.

I love you, baby,
but I can't marry you.

You really mean that.

But it doesn't
change anything.

For you.
Me, I want a future.

No matter how long
that might be.

I know it's bad news
or you would have
told me on the phone.

Well, actually,
the news is good.

Your response
to the Herceptin
is more successful

than I ever
thought possible.

It not only
stopped your tumor
from growing, Barbara,

it made it disappear.

My tumor's gone?

Your tumor's gone.

Now, you still have cancer,

but this is
an exceptional result,
amazing, even.

I'm sorry, I was...

I was expecting the worst.

Well, it's nice to get
some good news for a change.

Yeah.

Now, here's where we are.
We're almost done
with Phase One,

and I'm inviting you
to continue treatment
in Phase Two.

Whatever you say,
I'm there.
Good.

Now, you're gonna have
to sit tight for about
six weeks until we begin.

But I'll still be
getting my Herceptin?

No.

I can't give it
outside of the study.

That's FDA rules.
We have to apply
to begin Phase Two.

Don't worry, now.
It's just a formality.

What if my tumor
comes back?

If it does, I don't think
it's gonna grow fast
enough to be a danger.

And once you start
the Herceptin again,
it'll shrink. It'll be fine.

I have to ask you
not to tell the others.

Not all of them are gonna
be continuing to Phase Two.

Who's not coming?

I need to tell them first.

Yeah.

Yeah, of course.

Fresh from my garden.
Echinacea, for colds.

Works like a charm.

Thank you.

I know I'm here for
my official results,
but I already know.

Dr. Slamon,
I feel so much stronger.

You are doing better.

But?

I'm sorry, Tina.

You won't be
moving on to Phase Two.

Not moving on?

But you said last
week I was improving.

And you are.

But for the study,
for its ultimate success,

I've been given a set
of standards by the FDA.

I need to narrow
the group down

to the ones who are having
the most clear and
measurable response.

That's me.

I've gained weight,
and I'm not in pain
at all anymore.

You can see that.

I know that.

But the goal,
and we talked about this,

has been to get
Herceptin approved.

Now, in my heart,
I want you
to continue, Tina.

But in science,
it comes down
to the numbers.

And for the next phase,

and I'm sorry,
but your numbers,
they're not high enough.

Please.
Please, Dr. Slamon.

I have three children
and a husband.

Look, we'll pay
whatever it costs,
and nobody has to know.

I wish I could do that.

I can't.

I've never begged for
anything in my life.

But I'm begging you,
Doctor, for my life.

I'm sorry, for you,

for your family,
I'm sorry.

Sorry. How many...
How many lucky ones?

Five.

Well, I am happy for them.

Thank you, Doctor.

How could you do that?

It's part of my job.

You just sent
her home to die.

That's how it works.

That's not fair.

No, it's not.

That's not right.

It's not a question
of right or wrong.

I don't think
I can do this anymore.

But we will.

We have to stop
meeting like this.

Fran, what are
you doing here?

Oh, I was speaking
to a group of nurses.

And you? Yeah,
that's right.
You work here.

Hey. You were
supposed to call me
about Phase Three.

And I will,
as soon as I hear
that we're moving on.

We just finished Phase Two.

Six months ago.

I told you.
I'm watching.
I'm listening.

Trust me. When I
get the go-ahead,
I will call you.

I don't want to be notified.
I want to be involved.

I hear you
loud and clear.

Okay. Call.

Do I have a deal?
We have a deal.

Call! Okay.
I will.

I called you five times.

When were you
gonna call me back?

When I had an answer.
You just
called me yesterday.

Yeah, and last week
and the week before that,

and the month before that,
and five months before that!

When are we gonna
start Phase Three?

When Reinhart is
done designing it

and when the board
decides to pay for it,

which at this point
is not a sure thing.

That is ridiculous.

Herceptin works.
We proved it in
Phase One and Phase Two.

Why do I sound like
a broken record here?

Yes, Denny, One and Two
were successful,

but we still have
not proven anything!

That is what
Phase Three is for.

Acceptable clinical proof!

That's my point!

Don't yell at me!

Then get the board off
its overly-cautious ass
and get us the go-ahead.

You know what,
don't lecture me, either.

I'm not lecturing you, Blake.

For crying out loud,
how many times do we have
to go through this? I have...

Barbara and Dean
are waiting.

DENNY: Sorry I'm late.

I feel good. Please
don't tell me I'm not.

You're cancer-free.

What?

There's not one sign
of cancer in your body.

None.
How?

Part of it's the Herceptin.
The rest, I don't know.

But the cancer's
still there...
Barbara...

...it only takes one cell.
...you're cancer-free.

I read the results myself,
and I made them retest.

Cancer-free.

Cancer-free.

Free of cancer!

Cancer-free!

All I wanted to hear
were those words, and
I never thought I would!

And now I don't
know what to do!

What do I do?

Well, to be honest,

all of the other women
responded like I thought
they would,

they improved,
but your cancer's gone,
completely.

So, as for what
I would do,
just be grateful.

And by the way,
you don't have to
come here anymore.

Except to say hello.

Do you think
she misses us?

I know she does.

Just like we miss her.

Can I put it
on the tree?

I was just going to ask.

Merry Christmas.

Merry Christmas.

Merry Christmas.

Merry Christmas.

Merry Christmas, Mom.

Merry Christmas,
sweetheart.

I'm sorry. After
four years of remission,
your cancer is back.

The cancer has spread
to your lymph nodes
and your liver.

You'll need to get
your affairs in order.

Wow. People actually
say that. "Get your
affairs in order."

How long do I have?

Four months, maybe five.

How about chemo?

You've run that course.
I'm sorry.

You mean to tell me,
in this world-class
research hospital,

that's my only option?
How can that be?

Well, there is
one possibility.
It's a Phase Three Trial

and if approved,
it'll start soon,

but you have to
be HER-2 positive.

Am I?

I don't know.

But we'll find out.

Carl.
My afternoon's all booked.

I'll make it fast.
I just have a few ideas
about the trial design.

You've never designed
a drug trial before.

No, but I know more
about Herceptin than anyone.

Yeah, thank you.
I've got this
under control.

Come on, Carl.
Please, just hear me out.

To be honest, Denny,
I don't want
or need your input.

Look. I am the one
who's been in the trenches,

trying to find
the women that you need

to enroll in your
mess of a trial,

but I can't because
your requirements
are too strict.

In your opinion.
It's not just me.

Ask your "thought leaders."
You are running Phase Three
into the ground!

We're done here.
Okay.

If we could
just simplify...

I said we're done!

When is the last time
you told a patient
she was going to die?

Monica Stein.
Cindy Lopez. Jane Hart.
Sarah, Joan, Linda.

Those are just
the women that I had
to tell this week!

All of them are
HER-2 positive,

and all of them were
excluded from the trial

because they've
all had one too many
courses of chemo!

Well, it shouldn't
make a difference!

They should be eligible.

Is there room
in there for two?

As long as you
don't flip me over
like last time.

O ye of little faith.

There. See?
I'm not a total klutz.

It's over.

The trial's gonna fail.

No, it's not.
Yes, it is.

Reinhart's design
will see to that.

12 years.

12 years I've been
fighting it, for what?

A drug company that
just wishes I'd go away?

Promises I can't keep
to patients who
are counting on me?

All the time I missed

with you and the kids.

All for nothing.

You're my
long-distance runner.

You know what
you're gonna do?

You're gonna go to sleep,

and you're gonna wake up,

and you're gonna
fight your fight
until you win.

That's who you are.

Hello.
It took a year and a half,

but we're back on track.

Reinhart has
been transferred.

Wait, who's taking
his place?

I don't know,
but get this,

whoever it is
has marching orders
to save the study.

Can you believe it?
I'll call you later.

Yes!
Yeah, I'm calling to see

if I've been approved
for the study.

My name's Ellie Jackson.
No, I'll wait.

What do you mean,
no one's looked
at my paperwork?

You've had it
for two months.

Yes, I know it's July,
but I'm not on vacation.

I have to be approved
before the study starts,

so that I can start
on the first day.

Because I don't have
that many days left.

Thank you.

Okay, I'll cut to the chase.
We're trying to save
the Phase Three Trial,

and we don't have
enough participants,

and we're hoping
you can help.

So, let's see,
I could write
a cover letter

and send out
the information packets

to the 3,000 names
on my Rolodex

in exchange for which
you'll give me and another
breast cancer advocate

a say in the trial design.

Yes.

And compassionate
access to the drug,

for the women who do not
qualify for the trial.

We'd like to
do that, but...

No buts.

There are women
out there with no other
medical option,

except for
an experimental drug,
which does seem to work,

but they can't
have access to it.

And the FDA allows
compassionate access
in Phase Three studies.

Even so, there's
a very limited amount
of the drug available.

Make some more.

Tumor cell is sort of
blanketed by the HER-2.

If you would come
up with, kind of,

your top-three priorities,
that would help.

I don't have one
good slide here.
I can't believe that.

Come on. Let's go.

We got to get more
of these out. 16.

Hi. I'm here for
the Phase Three trial.

It took me all summer long,
but I just got approved.

Ellie Jackson. Welcome.
We're happy to have you,

except you're early.

I can just go get
a cup of coffee.

No, I didn't mean today.
We don't start
until next week.

That'll be too late.

It's just a week.

The trial was
just approved.

We aren't ready yet.
Come back next week.

I have been chasing people

and committees
around this hospital
for three months

trying to get approved
for this study,
to save my life.

And every time
I manage to get
somebody's attention,

they can't help me
because they're not ready.

They don't have my paperwork
or they're moving,
or they're on vacation,

or they're sitting at home
waiting for the cable guy.

I get it.

Life goes on.
People have jobs.

Things happen.

Well, cancer happened to me.

And I'll be damned
if I'm gonna die.

Not because there weren't
people here to help me,

but because
they weren't ready.

I'm dying in front
of you right now.

And if you have help
to give me, I need it now.

I need it right now!

Find Dr. Slamon.

Thank you.

Hi, Ellie. Dr. Slamon.

I'm sorry about
the scene out there.

Oh! Don't apologize.
Are you kidding?

Do you know how many
fits I've had to throw
around here myself?

It's ridiculous.

All right.

It's official.

You are the first
subject in Phase Three.
Congratulations.

Thank you, Dr. Slamon.

No, Ellie.

Thank you.

Carol's gonna be in
shortly, all right?

Okay.
Okay.

WOMAN OVER PA:
Congratulations,
runners and walkers,

you are halfway there.

Please visit
the water tables,

and we'll see you
at the finish line.

DONNA: Have you
seen Lilly?

I guess she's around
here somewhere.

Dr. Slamon?

Hi.
Hello.

I just wanted to
tell you, thank you.

Well, thank you.
Thank you.
Thank you so much.

Dr. Slamon. Thank you
for fighting for us.

All these people
know Dad?

Yeah, and they're
thanking him.

For what?

Helping them or
someone they love.

Dr. Slamon, I just wanted
to say thanks for giving
my mom more time.

Who's your mom?

Nicole Wilson.

Well, I think I should
be thanking you.

Your mother
was the first.

We wouldn't be
here without her.

Thank you, Doctor.
Thank you.
Thank you so much.

DENNY: Hey, buddy.

This is Slamon.

BLAKE: I'm coming
down today.

Meet me outside
your building at 4:30.
Don't be late.

Blake, why don't you
just come to my office?

Just be there.

Oh! Look, you're late.
I got a plane to catch.

Look, I read all
the data last night.

I wanted you to
hear it from me.

Well?

Congratulations.

We proved Herceptin
officially works.

More than anyone ever
imagined, except for you.

I got to get to DC.
I'm showing the
results to the FDA.

Do you need me to go?
I can go.

Denny, I think I can
handle this one.

Don't tell anyone
but Donna.

What about Lilly?

And Lilly.

Good work.
You, too.

What are you
doing home?

I just saw Blake.

Did you invite
him over for...

I love you, Mom.

All right! Yeah!

Yeah!

Run!

Yeah!

Yay!