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Would you like to inspect the original subtitles? These are the user uploaded subtitles that are being translated: 1 00:00:01,764 --> 00:00:04,531 [Water running] 2 00:00:08,792 --> 00:00:09,836 [Shower door opens] 3 00:00:09,921 --> 00:00:11,140 Oh! [Giggles] 4 00:00:16,654 --> 00:00:19,747 We can't both shower at the same time, Lea. 5 00:00:19,832 --> 00:00:22,630 One of us would block the steam of water for the other. 6 00:00:22,715 --> 00:00:24,989 Oh, Shaun, this is not for the purpose of cleanliness. 7 00:00:25,074 --> 00:00:27,997 This is for the purpose of having sex with you. 8 00:00:29,318 --> 00:00:30,724 Oh. 9 00:00:31,059 --> 00:00:32,607 N... No. No. 10 00:00:32,692 --> 00:00:35,239 It would be inconvenient, possibly dangerous. 11 00:00:35,412 --> 00:00:37,772 Soap might get into difficult places. 12 00:00:37,857 --> 00:00:39,201 If we leaned against the shower handle, 13 00:00:39,285 --> 00:00:40,545 we could scald ourselves. 14 00:00:40,630 --> 00:00:42,208 Bottles could be disarranged. 15 00:00:43,047 --> 00:00:44,534 It was just a thought. 16 00:00:44,619 --> 00:00:46,577 It was a bad thought. 17 00:00:46,662 --> 00:00:47,607 I'm surprised. 18 00:00:47,692 --> 00:00:49,341 You're such an intelligent person. 19 00:00:50,949 --> 00:00:53,779 I'll... Reset your alarm. 20 00:00:57,308 --> 00:00:59,840 DR LIM: It's a three-day weekend and a full moon. 21 00:00:59,925 --> 00:01:01,427 People are gonna do stupid things. 22 00:01:01,512 --> 00:01:04,372 I'm asking everyone to take an extra trauma call in the ER. 23 00:01:04,457 --> 00:01:06,445 Make yourselves available if you're needed. 24 00:01:06,530 --> 00:01:07,950 Questions? 25 00:01:08,794 --> 00:01:10,177 How'd you get the bruise? 26 00:01:10,274 --> 00:01:11,763 First casualty of the full moon. 27 00:01:11,848 --> 00:01:13,202 I smacked my head on a cupboard door 28 00:01:13,286 --> 00:01:14,554 when I was reaching for my coffee mug. 29 00:01:14,638 --> 00:01:15,825 Any other questions? 30 00:01:15,910 --> 00:01:18,761 Why is there a Subaru in your parking space? 31 00:01:18,846 --> 00:01:20,459 Because it's my car. 32 00:01:20,544 --> 00:01:21,544 You have a car? 33 00:01:21,645 --> 00:01:23,550 You're gonna be seeing a lot of it. I sold the Ducati. 34 00:01:23,634 --> 00:01:24,443 What? No. 35 00:01:24,544 --> 00:01:25,739 It just wasn't practical. 36 00:01:25,824 --> 00:01:27,029 Is it already gone? Because... 37 00:01:27,114 --> 00:01:29,508 A guy from Craigslist snatched it up. 38 00:01:29,637 --> 00:01:32,552 Any other questions... Not dealing with the bike? 39 00:01:34,575 --> 00:01:36,365 It wasn't that much of a bruise. 40 00:01:36,450 --> 00:01:37,604 [Cellphone chimes] 41 00:01:37,697 --> 00:01:39,646 But the doctor at the ski resort told us 42 00:01:39,731 --> 00:01:41,427 I might develop a hematoma? 43 00:01:41,557 --> 00:01:44,212 It's not unusual, but it'll need to be drained. 44 00:01:44,566 --> 00:01:47,458 I see you were treated for melanoma six years ago, 45 00:01:47,568 --> 00:01:49,483 and, more recently, breast cancer. 46 00:01:49,568 --> 00:01:50,950 Hence the ski trip. 47 00:01:51,146 --> 00:01:52,552 A celebration. 48 00:01:53,266 --> 00:01:54,756 One year cancer-free. 49 00:01:54,841 --> 00:01:56,841 - Also five years cancer-free. - [Cellphone chimes] 50 00:01:58,450 --> 00:02:02,052 I don't suppose a long needle will be involved in this? 51 00:02:02,255 --> 00:02:04,060 Your hematoma extends pretty deep, 52 00:02:04,145 --> 00:02:05,810 so the needle will have to be long. 53 00:02:05,895 --> 00:02:07,380 But it's over quickly. 54 00:02:07,465 --> 00:02:09,506 Sorry, I have to intervene before this deal goes south. 55 00:02:09,590 --> 00:02:11,513 You don't mind if I step out? 56 00:02:12,971 --> 00:02:15,685 Would you like us to wait for your husband to come back? 57 00:02:16,161 --> 00:02:17,458 No. 58 00:02:17,673 --> 00:02:18,958 Let's go ahead. 59 00:02:22,382 --> 00:02:24,433 DR REZNICK: How do you get frostbite in San Jose? 60 00:02:24,518 --> 00:02:25,823 Cryotherapy accident. 61 00:02:25,908 --> 00:02:27,661 I stayed in the booth a little too long. 62 00:02:27,746 --> 00:02:29,748 I was going to stand outside for the full three minutes, 63 00:02:29,832 --> 00:02:31,499 - but he said... - I said, "No need." 64 00:02:31,584 --> 00:02:33,380 I'd set the stopwatch on my phone, 65 00:02:33,465 --> 00:02:36,009 after which, my thoughts immediately drifted, and... 66 00:02:36,094 --> 00:02:38,747 - I came back to find him frozen in carbonite. - [Chuckles] 67 00:02:38,832 --> 00:02:41,096 You know, I'm more worried about the fever. 68 00:02:41,303 --> 00:02:43,162 Was the cryotherapy meant to treat something? 69 00:02:43,247 --> 00:02:44,435 No. Routine self-care. 70 00:02:44,520 --> 00:02:46,672 We've made life extension part of our health regime... 71 00:02:46,757 --> 00:02:49,318 Supplements, meditation, exercise. 72 00:02:49,465 --> 00:02:51,271 Three of my gaming apps have gone viral. 73 00:02:51,356 --> 00:02:54,194 I'm lucky enough to afford basically whatever I want, 74 00:02:54,279 --> 00:02:55,943 so I spend it on my health. 75 00:02:56,294 --> 00:02:59,443 No, I figure fever, must be an infection. 76 00:02:59,708 --> 00:03:02,802 Well, I know that frostbite can make you vulnerable. 77 00:03:02,887 --> 00:03:07,325 It just... It didn't seem severe enough to... 78 00:03:07,695 --> 00:03:10,099 Oh, sorry. I feel a little queasy. 79 00:03:10,288 --> 00:03:11,332 Aah! 80 00:03:11,417 --> 00:03:12,497 Wyatt. 81 00:03:12,598 --> 00:03:13,732 Ow! 82 00:03:19,993 --> 00:03:21,646 [Beeping] 83 00:03:21,970 --> 00:03:23,716 I need a medical transport team, stat. 84 00:03:23,804 --> 00:03:25,719 Perforated bowel. He needs immediate surgery. 85 00:03:26,057 --> 00:03:27,404 Theme music playing... 86 00:03:27,488 --> 00:03:29,488 *THE GOOD DOCTOR* Season 04 Episode 07 87 00:03:29,695 --> 00:03:31,871 Episode Title: "The Uncertainty Principle" Aired on: January 18, 2021 88 00:03:32,056 --> 00:03:34,114 Synchronized by srjanapala 89 00:03:35,793 --> 00:03:38,129 No. No. Why do people hate wind farms? 90 00:03:38,214 --> 00:03:39,982 Everyone thinks they're noisy. 91 00:03:40,228 --> 00:03:41,802 This could make a turbine sound as quiet 92 00:03:41,887 --> 00:03:43,338 as a page turning in a library. 93 00:03:43,423 --> 00:03:44,833 That's not worth our investing in? 94 00:03:44,918 --> 00:03:46,326 Did you even look... Hold on. 95 00:03:46,469 --> 00:03:48,122 Anything I need to know? 96 00:03:48,210 --> 00:03:49,380 Hematoma's drained. 97 00:03:49,465 --> 00:03:51,304 We're sending a sample to Pathology... Routine. 98 00:03:51,388 --> 00:03:52,739 Should have it back sometime tomorrow. 99 00:03:52,823 --> 00:03:54,310 - Thank you. - Mm-hmm. 100 00:03:55,008 --> 00:03:57,044 I couldn't help overhearing a little. 101 00:03:57,536 --> 00:03:59,411 Are you a venture capitalist? 102 00:04:00,414 --> 00:04:02,490 The only people who ask me if I'm a VC 103 00:04:02,575 --> 00:04:05,232 are people who want a VC to invest in their project. 104 00:04:06,976 --> 00:04:10,951 Maybe, after we get your wife healthy again, we could talk? 105 00:04:11,059 --> 00:04:12,209 Call whenever you're ready. 106 00:04:12,294 --> 00:04:13,966 My life is listening to ideas. 107 00:04:14,051 --> 00:04:15,437 If it's good, I'll run it by my two partners. 108 00:04:15,521 --> 00:04:16,341 If it's really good, 109 00:04:16,426 --> 00:04:18,794 we'll take a 30% equity position in your company. 110 00:04:20,921 --> 00:04:22,083 Yeah. 111 00:04:22,168 --> 00:04:25,060 Yeah, you're the one who wanted us to get into clean technology. 112 00:04:26,896 --> 00:04:29,021 I think I've been asked out on a date. 113 00:04:30,293 --> 00:04:31,724 Nice. 114 00:04:31,904 --> 00:04:33,107 No, I work with him. 115 00:04:33,192 --> 00:04:34,927 Hasn't stopped you before. I supervise him. 116 00:04:35,012 --> 00:04:36,110 Schedules can be changed. 117 00:04:36,195 --> 00:04:37,936 He's polyamorous. 118 00:04:38,615 --> 00:04:40,896 Unless he also texted you a ring, it's just a date. 119 00:04:40,981 --> 00:04:42,560 And you need to get out more. 120 00:04:43,711 --> 00:04:45,029 So do I. 121 00:04:47,661 --> 00:04:48,880 [Gloves snap] 122 00:04:51,273 --> 00:04:53,747 DR ANDREWS: You want to take down the splenocolic ligament. 123 00:04:54,060 --> 00:04:56,889 Just don't nick the inferior mesenteric artery. 124 00:04:57,118 --> 00:05:00,731 ASHER: I feel the I.M.A. under my finger. 125 00:05:00,888 --> 00:05:02,890 Placing the stapler. 126 00:05:03,287 --> 00:05:04,872 And cutting. 127 00:05:05,658 --> 00:05:07,240 I voted "approve." 128 00:05:09,883 --> 00:05:11,363 Disapprove. 129 00:05:11,607 --> 00:05:12,999 No opinion. 130 00:05:13,220 --> 00:05:14,220 There's a poll? 131 00:05:14,345 --> 00:05:16,724 Yes... About shower sex. 132 00:05:16,809 --> 00:05:19,458 I know it's wrong to discuss shower sex at work, 133 00:05:19,543 --> 00:05:21,055 so I did a poll instead. 134 00:05:21,276 --> 00:05:22,497 Much better. 135 00:05:22,582 --> 00:05:25,108 Dr. Murphy, do you really want people knowing the details 136 00:05:25,193 --> 00:05:26,482 of your personal life? 137 00:05:26,567 --> 00:05:29,872 You don't think they took it as an abstract question? 138 00:05:29,957 --> 00:05:32,841 No. We all take it as something that happened between you and Lea. 139 00:05:32,926 --> 00:05:34,083 And that there was a fight. 140 00:05:34,168 --> 00:05:35,678 DR PARK: Sometime before 8:00 a.m. today, 141 00:05:35,762 --> 00:05:37,763 which was when the poll was sent out. 142 00:05:38,974 --> 00:05:40,889 You are very astute. 143 00:05:40,974 --> 00:05:44,328 I'm seeing diffuse dilation of the large bowel here. 144 00:05:44,452 --> 00:05:45,919 Is that normal? 145 00:05:46,564 --> 00:05:49,255 Some calcified lesions. 146 00:05:49,838 --> 00:05:51,361 Wall's thin, too. 147 00:05:51,446 --> 00:05:52,630 Hirschsprung's. 148 00:05:52,715 --> 00:05:54,553 I thought Hirschsprung's was a disease only babies 149 00:05:54,637 --> 00:05:55,644 and young children got. 150 00:05:55,729 --> 00:05:56,943 It is. 151 00:05:57,643 --> 00:05:59,060 But he has it. 152 00:06:06,269 --> 00:06:07,878 We treated the Hirschsprung's 153 00:06:07,963 --> 00:06:10,035 by removing the dilated part of your colon. 154 00:06:10,120 --> 00:06:11,842 It won't impact your life, 155 00:06:11,927 --> 00:06:13,590 but we would like an explanation. 156 00:06:13,675 --> 00:06:14,841 DR PARK: Dr. Murphy doesn't mean 157 00:06:14,925 --> 00:06:16,512 we expect you to be a diagnostician. 158 00:06:16,597 --> 00:06:17,777 It's just... 159 00:06:17,902 --> 00:06:19,456 This was kind of singular. 160 00:06:19,722 --> 00:06:22,143 So, if you have any thoughts... 161 00:06:22,228 --> 00:06:25,589 Did anyone in your family suddenly develop these symptoms? 162 00:06:28,709 --> 00:06:32,620 I did something singular to myself about six months ago. 163 00:06:33,144 --> 00:06:35,058 I modified my genetic code. 164 00:06:35,429 --> 00:06:38,246 I did a CRISPR procedure under the guidance of some researchers 165 00:06:38,331 --> 00:06:39,652 I know in China through my work. 166 00:06:39,737 --> 00:06:41,488 They put together a series of cocktails. 167 00:06:41,573 --> 00:06:45,887 They FedExed them to be, and Sophie helped me inject them 168 00:06:45,972 --> 00:06:47,098 into my bone marrow. 169 00:06:47,183 --> 00:06:48,268 Why? 170 00:06:48,442 --> 00:06:49,957 If you know anything about CRISPR, 171 00:06:50,042 --> 00:06:52,006 you know how risky it is to tinker with your genome. 172 00:06:52,090 --> 00:06:54,711 You have no idea what problems you might let loose. 173 00:06:54,796 --> 00:06:57,308 I needed to optimize my telomerase activity. 174 00:06:57,425 --> 00:06:58,997 It's the enzyme responsible for correcting 175 00:06:59,081 --> 00:07:00,121 cell replication errors, 176 00:07:00,206 --> 00:07:01,228 essentially, the cause of aging. 177 00:07:01,312 --> 00:07:02,487 SHAWN: You can't stop aging 178 00:07:02,572 --> 00:07:04,698 through changing your telomerase activity. 179 00:07:04,783 --> 00:07:08,285 You might extend your life a little, but exercise... 180 00:07:08,370 --> 00:07:10,910 It does the same thing. Much less risky. 181 00:07:10,995 --> 00:07:12,440 Your decision makes no sense. 182 00:07:12,525 --> 00:07:15,854 Extending my life by a few years is only my short-term goal. 183 00:07:16,023 --> 00:07:17,981 Look, you know how fast medicine is moving. 184 00:07:18,066 --> 00:07:19,940 The day isn't that far away when cloning 185 00:07:20,025 --> 00:07:22,945 will make transplants as easy as switching out a light socket. 186 00:07:23,030 --> 00:07:24,816 AI will start to make breakthroughs 187 00:07:24,901 --> 00:07:26,424 that we can't predict or understand. 188 00:07:26,536 --> 00:07:29,479 Medical knowledge will rise exponentially. 189 00:07:29,564 --> 00:07:32,191 There are babies born now who could live to see it, 190 00:07:32,276 --> 00:07:34,292 could live to be 1,000 years old. 191 00:07:34,423 --> 00:07:36,173 Maybe more. Maybe forever. 192 00:07:36,267 --> 00:07:38,530 Or at least, as long as they want to. 193 00:07:38,698 --> 00:07:40,980 So, our plan is to give my CRISPR a year 194 00:07:41,065 --> 00:07:43,077 to make sure the telomerase change works, 195 00:07:43,162 --> 00:07:45,307 and then we'll do her. 196 00:07:47,135 --> 00:07:49,267 We'll aspirate a sample of your bone marrow. 197 00:07:49,352 --> 00:07:51,192 See if we can figure out what the hell you did. 198 00:07:53,103 --> 00:07:54,440 [Elevator bell dings] 199 00:07:58,523 --> 00:07:59,741 Hey. 200 00:07:59,826 --> 00:08:03,830 Um... I don't think coffee's a good idea. 201 00:08:04,375 --> 00:08:06,203 Entire civilizations rely on it. 202 00:08:06,290 --> 00:08:08,215 But I don't think you're referring to the beverage itself. 203 00:08:08,299 --> 00:08:10,089 I don't think it's a good idea for first-years 204 00:08:10,173 --> 00:08:11,346 and fourth-years to go out. 205 00:08:11,431 --> 00:08:14,474 I am bound to supervise you at some point in the future, 206 00:08:14,559 --> 00:08:17,565 and it'd get complicated trying to change dates out, 207 00:08:17,650 --> 00:08:20,291 and the fact is... 208 00:08:20,514 --> 00:08:23,649 Seeing somebody you work with rarely ends happily. 209 00:08:23,734 --> 00:08:24,955 - So, I appreciate - Oh, you 210 00:08:25,040 --> 00:08:27,200 - you thinking of me, but I... - thought it was a date. 211 00:08:28,848 --> 00:08:30,838 I'm still new here, and I thought it was 212 00:08:30,924 --> 00:08:33,463 a good opportunity to get to know each other. 213 00:08:33,836 --> 00:08:36,072 Coffee's perfect because you're asking 214 00:08:36,157 --> 00:08:38,508 the least amount of commitment from another human being. 215 00:08:38,845 --> 00:08:40,471 It's not even lunch. 216 00:08:40,956 --> 00:08:42,915 If it's still a "no," it's still a "no," 217 00:08:43,143 --> 00:08:45,010 but I'll let you re-think your answer. 218 00:08:58,909 --> 00:09:01,477 He only claimed it wasn't a date to save face. 219 00:09:01,690 --> 00:09:03,823 Or maybe I just assumed. 220 00:09:04,131 --> 00:09:05,417 But why did I assume? 221 00:09:05,502 --> 00:09:07,513 I don't think I'm some kind of narcissist 222 00:09:07,598 --> 00:09:10,193 who thinks every man wants to get close to me. 223 00:09:10,705 --> 00:09:14,005 Or we both assumed it's a date because it's a date. 224 00:09:14,224 --> 00:09:16,185 This is fun. I like being your bestie. 225 00:09:16,270 --> 00:09:17,583 Slumber party? 226 00:09:21,104 --> 00:09:22,768 [Door opens] 227 00:09:23,615 --> 00:09:26,459 I made a poll to test the popularity of shower sex. 228 00:09:26,544 --> 00:09:27,775 I heard. 229 00:09:27,860 --> 00:09:29,906 I fielded some questions about that. 230 00:09:29,991 --> 00:09:34,487 "Approve" has won, but don't get too excited, Lea. 231 00:09:34,572 --> 00:09:36,900 It's only 58-38, 232 00:09:36,985 --> 00:09:39,291 with several complicated noncommittals, 233 00:09:39,395 --> 00:09:41,814 so clearly my attitude is reasonable. 234 00:09:41,939 --> 00:09:43,893 We don't have room for a... 235 00:09:43,978 --> 00:09:46,252 Skier exercise thing. 236 00:09:46,383 --> 00:09:49,331 I'm only putting it together so I can take a picture 237 00:09:49,416 --> 00:09:50,713 and sell it online. 238 00:09:50,798 --> 00:09:52,783 Why do you have it if you don't want it? 239 00:09:58,822 --> 00:10:01,463 My ex sent it. 240 00:10:02,562 --> 00:10:04,042 "Ex"? 241 00:10:04,268 --> 00:10:05,979 Husband. 242 00:10:07,744 --> 00:10:09,144 I left this thing in the attic 243 00:10:09,229 --> 00:10:11,338 until I got settled somewhere with enough space. 244 00:10:11,423 --> 00:10:13,244 And okay, that was 10 years ago, 245 00:10:13,400 --> 00:10:15,346 but it's not like it was in his way. 246 00:10:18,625 --> 00:10:22,907 We got married, not for long, right out of high school. 247 00:10:22,992 --> 00:10:24,578 Literally the boy next door. 248 00:10:24,696 --> 00:10:26,742 We grew up together. People expected it. 249 00:10:26,827 --> 00:10:29,922 It... Was a big mistake. 250 00:10:30,007 --> 00:10:32,391 We both realized it pretty quickly. 251 00:10:36,678 --> 00:10:38,758 ENRIQUE: Why would you even want to live forever? 252 00:10:38,844 --> 00:10:40,391 You'd be bored out of your mind. 253 00:10:40,476 --> 00:10:41,290 [Chuckles] 254 00:10:41,375 --> 00:10:42,751 The person I am now 255 00:10:42,836 --> 00:10:46,750 is... miles away from the person I was at 14. 256 00:10:47,516 --> 00:10:49,687 I only get more distant every year. 257 00:10:50,721 --> 00:10:54,336 You learn to understand, 258 00:10:55,252 --> 00:10:57,976 love books that you once hated, 259 00:10:59,028 --> 00:11:01,734 sometimes people you once hated. 260 00:11:01,907 --> 00:11:06,259 Music that you didn't get the point of becomes magical. 261 00:11:06,731 --> 00:11:08,690 And a thousand new doors will open. 262 00:11:08,775 --> 00:11:11,082 I look forward to the adventure. 263 00:11:11,336 --> 00:11:12,492 [NEEDLE SQUELCHES]Ow. 264 00:11:12,577 --> 00:11:15,430 Sorry. Adventure's not always gonna be fun. 265 00:11:16,555 --> 00:11:20,182 I figure it takes 40 or 50 years 266 00:11:20,267 --> 00:11:22,586 just to get over the things your parents did. 267 00:11:22,731 --> 00:11:24,341 If only we lived long enough, 268 00:11:24,426 --> 00:11:28,492 the human race might finally have a chance to grow up. 269 00:11:35,283 --> 00:11:37,242 What size shoes do you wear? 270 00:11:37,374 --> 00:11:39,133 Seven and a half. 271 00:11:39,815 --> 00:11:42,062 "Dr. Allen's Walking On Clouds Inserts." 272 00:11:42,147 --> 00:11:44,517 Putting "doctor" in the name is always good marketing strategy. 273 00:11:44,601 --> 00:11:47,082 They're designed to reduce inflammation 274 00:11:47,555 --> 00:11:49,209 that could lead to plantar fasciitis, 275 00:11:49,383 --> 00:11:52,342 calluses, arthritis, and they feel damn good. 276 00:11:52,516 --> 00:11:53,996 Does this have anything to do with our patient's 277 00:11:54,080 --> 00:11:55,356 venture capitalist husband? 278 00:11:55,441 --> 00:11:56,869 I need testimonials. 279 00:11:56,954 --> 00:11:58,402 Labs and Path for Hannah Palmer. 280 00:12:01,572 --> 00:12:04,206 Aren't we all busy enough learning how to be surgeons? 281 00:12:04,674 --> 00:12:07,230 Do you really want to divide your focus onto something trivial? 282 00:12:12,139 --> 00:12:15,394 Because wanting to make money taints the purity of medicine? 283 00:12:17,044 --> 00:12:18,785 I have five brothers. 284 00:12:18,870 --> 00:12:21,133 I've been taking care of people my whole life. 285 00:12:21,248 --> 00:12:24,556 Someone got hurt, they came to me to patch them up. 286 00:12:24,863 --> 00:12:27,956 I became a doctor so I could get paid for it, 287 00:12:28,104 --> 00:12:31,128 but also because I'm good at taking care of people. 288 00:12:31,349 --> 00:12:33,824 It's possible to do something for more than one reason. 289 00:12:44,986 --> 00:12:46,613 The news is bad. 290 00:12:55,728 --> 00:12:59,089 There's an abnormally healthy population 291 00:12:59,174 --> 00:13:02,097 of hematopoietic progenitor stem cells. 292 00:13:02,262 --> 00:13:04,331 - He did it? - It's significant. 293 00:13:04,416 --> 00:13:07,608 He's succeeded in optimizing enough telomerase activity 294 00:13:07,693 --> 00:13:10,144 to potentially add 10 years to his natural life. 295 00:13:10,229 --> 00:13:12,550 DR ANDREWS: Well, assuming it doesn't subtract about 50. 296 00:13:12,635 --> 00:13:14,284 There's already an autoimmune reaction 297 00:13:14,369 --> 00:13:15,452 - that mimics - Hirschsprung's. 298 00:13:15,536 --> 00:13:16,605 Who knows what else he did? 299 00:13:16,699 --> 00:13:19,105 What if this is the opposite of an auto-immune condition? 300 00:13:19,190 --> 00:13:20,452 What if he's done something 301 00:13:20,537 --> 00:13:22,284 that lowers his resistance to infection? 302 00:13:22,369 --> 00:13:24,800 Then we'd be seeing more opportunistic infections 303 00:13:24,885 --> 00:13:26,060 of the lungs and skin. 304 00:13:26,239 --> 00:13:28,003 If you lived another 1,000 years, 305 00:13:28,088 --> 00:13:30,313 would you be with the same person at the end 306 00:13:30,397 --> 00:13:31,550 as at the beginning? 307 00:13:31,650 --> 00:13:32,956 - No. - No. 308 00:13:33,890 --> 00:13:35,500 No, if you assume monogamy. 309 00:13:35,585 --> 00:13:37,504 I mean, that puts too much strain on a relationship. 310 00:13:37,588 --> 00:13:39,606 Is one person supposed to be everything to another, 311 00:13:39,691 --> 00:13:41,304 all the time, for 1,000 years? 312 00:13:41,389 --> 00:13:45,156 Apparently Jesus agrees. On monogamy. 313 00:13:45,241 --> 00:13:47,632 He said that, in Heaven, there'll be no more marriages. 314 00:13:47,717 --> 00:13:50,953 I guess humans can't sustain a relationship that long. 315 00:13:51,092 --> 00:13:52,332 You read the New Testament, too? 316 00:13:52,417 --> 00:13:54,843 And the Qur'an. And other things. 317 00:13:54,928 --> 00:13:56,211 It's like you're a stalker. 318 00:13:56,296 --> 00:13:58,603 It's like you and God had an acrimonious divorce. 319 00:13:58,794 --> 00:14:02,242 What if he caused neurofibromatosis? 320 00:14:02,362 --> 00:14:04,640 Microscopic tumors forming on the nerve sheath? 321 00:14:04,725 --> 00:14:06,273 Mm. Possible, but there'd have been 322 00:14:06,358 --> 00:14:07,665 some evidence of Schwann cell growth 323 00:14:07,749 --> 00:14:08,851 around his colon. 324 00:14:08,936 --> 00:14:11,437 Would you still love your wife in 1,000 years? 325 00:14:13,423 --> 00:14:15,469 You have three answers. That should be enough. 326 00:14:15,569 --> 00:14:18,000 Park's marriage failed in far less time, 327 00:14:18,085 --> 00:14:19,390 and Enrique doesn't even try. 328 00:14:19,475 --> 00:14:20,955 Asher is an... 329 00:14:21,106 --> 00:14:22,542 Unknown quantity. 330 00:14:22,663 --> 00:14:23,778 You're committed. 331 00:14:23,863 --> 00:14:25,732 You've made promises. 332 00:14:27,917 --> 00:14:30,061 I've made promises based on 333 00:14:30,177 --> 00:14:33,271 an understood human life-span, Murphy. 334 00:14:33,893 --> 00:14:36,998 Most likely diagnosis is autoimmune polyneuropathy. 335 00:14:37,117 --> 00:14:38,679 It damaged the enteral ganglion nerve 336 00:14:38,764 --> 00:14:39,951 and led to the perforations. 337 00:14:40,036 --> 00:14:42,389 Start him on steroids and immunosuppressants. 338 00:14:42,855 --> 00:14:44,073 Dr. Andrews. 339 00:14:44,158 --> 00:14:46,204 So, you wouldn't have gotten married 340 00:14:46,289 --> 00:14:47,986 if you thought it would be forever. 341 00:14:48,071 --> 00:14:50,699 You expect all relationships to fail over time. 342 00:14:50,784 --> 00:14:52,920 It's just a question of how long? 343 00:14:54,288 --> 00:14:55,967 I love her now. 344 00:14:56,604 --> 00:15:00,045 I intend to love her as long as I live. 345 00:15:01,006 --> 00:15:05,553 But, eventually, everything breaks. 346 00:15:14,391 --> 00:15:15,701 I always go back to comfort reading 347 00:15:15,785 --> 00:15:16,920 when I'm in the hospital. 348 00:15:17,005 --> 00:15:18,998 Cozy mysteries in little English villages, 349 00:15:19,083 --> 00:15:21,660 where nothing bad happens to anyone we like. 350 00:15:23,132 --> 00:15:24,777 We've gotten your results back. 351 00:15:24,925 --> 00:15:26,210 When will your husband be... 352 00:15:26,295 --> 00:15:27,730 Is it cancer? 353 00:15:29,833 --> 00:15:31,183 Yes. 354 00:15:33,109 --> 00:15:34,800 Thyroid carcinoma. 355 00:15:35,566 --> 00:15:37,574 We're gonna do a complete imaging series 356 00:15:37,666 --> 00:15:38,745 to pinpoint just how advanced... 357 00:15:38,829 --> 00:15:40,066 Treatment? 358 00:15:40,742 --> 00:15:44,034 Surgery to remove some or all of your thyroid 359 00:15:44,119 --> 00:15:46,382 is usually the first line of defense. 360 00:15:46,501 --> 00:15:49,329 Sometimes, we can wait, but given the hematoma 361 00:15:49,414 --> 00:15:53,089 was probably caused by the tumor invading nearby vasculatures, 362 00:15:53,285 --> 00:15:55,632 - we should probably do it in the next few days. - [Wheezes] 363 00:15:55,716 --> 00:15:58,738 Later, there'll be radioactive iodine treatment... 364 00:15:58,929 --> 00:16:00,355 [Wheezes] 365 00:16:00,533 --> 00:16:01,449 Panic attack? 366 00:16:01,534 --> 00:16:04,222 [Wheezing] 367 00:16:07,458 --> 00:16:09,199 Her trachea's deviated to the right. 368 00:16:09,284 --> 00:16:11,496 The tumor's compressing it. We're doing surgery now. 369 00:16:11,674 --> 00:16:14,041 [Groaning] 370 00:16:15,441 --> 00:16:18,183 [Monitor beeping] 371 00:16:22,522 --> 00:16:24,307 What happened? The nurse just said "surgery." 372 00:16:24,392 --> 00:16:26,010 Was it the hematoma? 373 00:16:26,886 --> 00:16:27,974 It's more serious. 374 00:16:29,925 --> 00:16:32,101 It... It's not cancer... 375 00:16:32,573 --> 00:16:34,018 Again. 376 00:16:34,329 --> 00:16:36,128 Thyroid carcinoma. 377 00:16:37,150 --> 00:16:39,892 We've removed her thyroid. She's doing well. 378 00:16:40,114 --> 00:16:41,784 We're looking into potential causes... 379 00:16:41,948 --> 00:16:43,761 Genetic, environmental. 380 00:16:43,846 --> 00:16:47,823 There may be a deeper issue that we can find and address. 381 00:16:57,874 --> 00:16:59,514 I can't do this. 382 00:17:01,660 --> 00:17:03,350 You've done it before. 383 00:17:04,458 --> 00:17:06,154 You'll do it this time. 384 00:17:11,857 --> 00:17:13,670 Do you know what it's like... 385 00:17:14,405 --> 00:17:16,147 To wake up every morning and know your wife 386 00:17:16,240 --> 00:17:18,006 might not be here next year? 387 00:17:19,618 --> 00:17:22,694 All those treatments... 388 00:17:22,932 --> 00:17:26,442 They all... They all have this little tag attached to them 389 00:17:26,527 --> 00:17:29,487 that says, "Because she might die." 390 00:17:30,014 --> 00:17:33,264 And you see them put those gloves on 391 00:17:33,495 --> 00:17:34,544 before they hook up the chemo. 392 00:17:34,628 --> 00:17:36,108 You know why they do that. 393 00:17:37,493 --> 00:17:39,053 It's because it's poison. 394 00:17:41,519 --> 00:17:43,350 And you sit there... 395 00:17:44,563 --> 00:17:47,522 And you watch them shove poison into the person you love. 396 00:17:48,185 --> 00:17:49,631 And why? 397 00:17:51,289 --> 00:17:53,131 Because she might die. 398 00:17:55,857 --> 00:17:58,561 We're killing her because she might die. 399 00:18:03,213 --> 00:18:04,670 Go for a run. 400 00:18:05,115 --> 00:18:06,740 Go punch a wall. 401 00:18:07,262 --> 00:18:08,902 You need to release some endorphins. 402 00:18:08,987 --> 00:18:10,423 My release is my job. 403 00:18:10,990 --> 00:18:12,601 That's why I love it. 404 00:18:12,775 --> 00:18:15,647 My work requires total focus. 405 00:18:15,732 --> 00:18:16,907 And every minute I'm working 406 00:18:16,992 --> 00:18:19,161 is a minute I'm not thinking about... 407 00:18:19,748 --> 00:18:21,231 Losing her. 408 00:18:26,318 --> 00:18:27,674 I have to go. 409 00:18:33,673 --> 00:18:37,078 Your pain and weakness are consistent with polyneuropathy, 410 00:18:37,163 --> 00:18:39,596 treatable with steroids and immunosuppressants. 411 00:18:39,703 --> 00:18:42,815 If you live 1,000 years, will you still love Sophie? 412 00:18:45,285 --> 00:18:46,460 Yes. 413 00:18:46,545 --> 00:18:48,329 How can you be sure? 414 00:18:48,420 --> 00:18:50,901 People change. You expect to change. 415 00:18:51,447 --> 00:18:54,166 Sophie and I will change together. 416 00:18:54,356 --> 00:18:55,636 We'll go through the same adventures 417 00:18:55,720 --> 00:18:56,764 and learn the same lessons. 418 00:18:56,849 --> 00:18:59,089 What if you go through the same adventures 419 00:18:59,174 --> 00:19:00,800 and learn different lessons? 420 00:19:00,885 --> 00:19:03,933 Even if we did, whoever, whatever we become, 421 00:19:04,018 --> 00:19:05,644 Sophie will always be beautiful. 422 00:19:05,729 --> 00:19:08,363 I mean, she could turn into a machine or a set of pixels 423 00:19:08,448 --> 00:19:11,339 or a giant purple flower, and she'll still be beautiful, 424 00:19:11,424 --> 00:19:14,261 because it's part of her essential nature. 425 00:19:17,329 --> 00:19:20,042 But if you don't know how you'll change, 426 00:19:20,233 --> 00:19:21,670 you don't know how you'll change. 427 00:19:21,755 --> 00:19:23,274 Shaun. 428 00:19:24,253 --> 00:19:25,515 We'll let you get some rest. 429 00:19:25,611 --> 00:19:28,066 The steroids should make you feel a lot better. 430 00:19:34,357 --> 00:19:38,425 Why didn't you ever mention you had an ex-husband? 431 00:19:39,076 --> 00:19:42,949 Shaun, I've barely thought about him in years. 432 00:19:43,272 --> 00:19:46,754 I didn't mention him because he's not important. 433 00:19:47,217 --> 00:19:49,925 I know. That's the problem. 434 00:19:50,256 --> 00:19:53,259 At one time, you felt he was important enough to your life 435 00:19:53,344 --> 00:19:56,521 to marry him, and now you barely think of him. 436 00:19:56,963 --> 00:20:00,706 You make long-term plans, you have expectations, 437 00:20:00,796 --> 00:20:02,493 and then something happens to you, 438 00:20:02,578 --> 00:20:05,277 and suddenly you're a different person. 439 00:20:06,628 --> 00:20:11,146 I know you don't like change, but it's not all bad. 440 00:20:11,820 --> 00:20:16,129 After all, you are working to change yourself all the time. 441 00:20:16,311 --> 00:20:22,261 I'm working to be a better surgeon, a better boyfriend, 442 00:20:22,346 --> 00:20:24,918 better at the things I've chosen, 443 00:20:25,003 --> 00:20:26,316 but this... 444 00:20:26,401 --> 00:20:28,183 Other change... It's unpredictable. 445 00:20:28,300 --> 00:20:29,174 You don't choose it. 446 00:20:29,259 --> 00:20:31,097 It just comes at you. 447 00:20:31,342 --> 00:20:34,144 Oh, it's like hurricanes before 1873, 448 00:20:34,229 --> 00:20:36,231 when the Army Signal Corps first put up flags 449 00:20:36,316 --> 00:20:37,706 to warn people storms were coming. 450 00:20:37,791 --> 00:20:40,480 Before that, houses were flattened, lives destroyed, 451 00:20:40,565 --> 00:20:42,722 and there was no way to see it was heading for you. 452 00:20:42,941 --> 00:20:44,183 Shaun. 453 00:20:45,005 --> 00:20:48,526 Our relationship will not end in natural disaster. 454 00:20:48,867 --> 00:20:50,259 It did begin in one. 455 00:20:52,707 --> 00:20:55,492 I'm going to look in on my patient. 456 00:20:56,183 --> 00:20:57,750 Okay. 457 00:21:04,507 --> 00:21:07,771 Blood and saliva will tell us if there's a genetic cause, 458 00:21:08,172 --> 00:21:09,925 and the samples we take from your house 459 00:21:10,042 --> 00:21:12,206 will tell us if there's something environmental. 460 00:21:13,879 --> 00:21:16,347 I know it's s... Stupid. 461 00:21:17,529 --> 00:21:20,065 I've almost felt guilty for my cancer, 462 00:21:20,150 --> 00:21:24,573 like I... arbitrarily decided to be sick and burdensome. 463 00:21:26,877 --> 00:21:28,347 Do the people you're close to 464 00:21:28,432 --> 00:21:31,105 ever act like you're a burden to them? 465 00:21:31,190 --> 00:21:32,451 You mean Alan. 466 00:21:34,716 --> 00:21:36,401 He's scared. 467 00:21:36,684 --> 00:21:40,557 He takes the exit he's got and he turns to his work. 468 00:21:41,067 --> 00:21:42,286 You're okay with that? 469 00:21:50,303 --> 00:21:52,707 I accept this compromise. 470 00:21:52,792 --> 00:21:53,840 That's not the hard part. 471 00:21:53,925 --> 00:21:55,323 The hard part is... 472 00:21:55,962 --> 00:21:57,401 Not knowing. 473 00:21:59,034 --> 00:22:02,511 Each new thing that happens, I worry, "Is this it? 474 00:22:03,729 --> 00:22:05,776 "Is this where I lose him? 475 00:22:06,836 --> 00:22:08,636 "Is this where he breaks?" 476 00:22:16,025 --> 00:22:18,097 CLAIRE: So, this is boiled coffee. 477 00:22:18,318 --> 00:22:20,253 Some people call it "Turkish coffee," 478 00:22:20,338 --> 00:22:23,211 or "Greek coffee," or "Egyptian coffee"... 479 00:22:23,306 --> 00:22:24,529 Because we need to take ownership 480 00:22:24,613 --> 00:22:25,899 and put things in categories. 481 00:22:25,984 --> 00:22:27,323 Yeah. 482 00:22:27,782 --> 00:22:29,436 You actually live in this thing, 483 00:22:29,536 --> 00:22:31,451 in the hospital parking garage? 484 00:22:31,621 --> 00:22:32,621 Why not? 485 00:22:32,706 --> 00:22:34,055 Convenient for work. 486 00:22:34,140 --> 00:22:36,540 When I want to spend a few days off the beaten track, 487 00:22:36,625 --> 00:22:38,407 it's convenient for that, too. 488 00:22:38,671 --> 00:22:41,457 Ooh. I'm gonna get three sips in this. 489 00:22:41,584 --> 00:22:43,516 But three really great sips. 490 00:22:45,295 --> 00:22:47,079 That's how I try to live my life... 491 00:22:47,308 --> 00:22:51,558 Try to appreciate, savor, not pass by. 492 00:22:54,427 --> 00:22:56,785 Is that what the polyamory is about? 493 00:22:57,770 --> 00:23:00,598 Does it really work, or is it one of those theories about life 494 00:23:00,683 --> 00:23:02,206 that people regret later? 495 00:23:02,348 --> 00:23:03,567 No regrets so far. 496 00:23:03,652 --> 00:23:05,262 Mm-hmm. No, I guess not. 497 00:23:05,347 --> 00:23:08,263 Not while you're young and having fun. 498 00:23:08,499 --> 00:23:09,587 It is fun, 499 00:23:09,847 --> 00:23:11,595 but not for the reasons that you're thinking. 500 00:23:11,679 --> 00:23:13,425 It isn't about sex. 501 00:23:13,879 --> 00:23:16,816 It's about commitment, emotional connection. 502 00:23:16,901 --> 00:23:19,152 The joy I'm sure you get out of a relationship, 503 00:23:19,237 --> 00:23:20,238 I get a little more. 504 00:23:20,323 --> 00:23:22,412 Also, I have to give a little more. 505 00:23:22,505 --> 00:23:24,594 But that's meaningful, too. 506 00:23:25,425 --> 00:23:26,667 Hmm. 507 00:23:27,621 --> 00:23:29,231 Do you mind if I ask you something, 508 00:23:29,316 --> 00:23:31,105 since we're getting personal? 509 00:23:34,794 --> 00:23:36,261 Sure. 510 00:23:36,903 --> 00:23:38,687 What's your favorite misheard song lyric? 511 00:23:40,338 --> 00:23:42,688 [Laughs] 512 00:23:47,415 --> 00:23:48,861 This is nice. 513 00:23:50,979 --> 00:23:53,372 I'm glad it's not a date. 514 00:23:53,468 --> 00:23:54,948 Me, too. 515 00:23:55,033 --> 00:23:56,579 I don't believe in those categories. 516 00:24:00,845 --> 00:24:02,055 [MACHINE BEEPING] 517 00:24:02,140 --> 00:24:03,095 He reported widespread 518 00:24:03,180 --> 00:24:03,923 bilateral pain, 519 00:24:04,039 --> 00:24:04,868 then he keeled over. 520 00:24:04,953 --> 00:24:06,391 B.P. dropped to 80 over palp. 521 00:24:06,476 --> 00:24:07,564 I'll order a vasopressor. 522 00:24:07,649 --> 00:24:08,662 Already did.Good. 523 00:24:08,747 --> 00:24:12,599 We need an EKG, CBC, and chest images, and a new diagnosis. 524 00:24:12,693 --> 00:24:15,217 Whatever he caused with CRISPR, it's not just neuropathy. 525 00:24:15,532 --> 00:24:17,216 Something else is killing him. 526 00:24:23,630 --> 00:24:25,327 What if he's caused something that mimics 527 00:24:25,412 --> 00:24:26,505 carcinomatous autonomic neuropathy? 528 00:24:26,589 --> 00:24:29,731 It explains the B.P. and bowel issue. 529 00:24:29,973 --> 00:24:32,973 That doesn't explain the sensory issue that led to the frostbite. 530 00:24:36,192 --> 00:24:37,779 A connective tissue disorder? 531 00:24:37,864 --> 00:24:39,263 That would have shown up on the scans. 532 00:24:39,347 --> 00:24:40,919 His chest looks normal. 533 00:24:45,785 --> 00:24:47,201 Maybe we can't think of the answer 534 00:24:47,286 --> 00:24:48,268 because there is no answer. 535 00:24:48,353 --> 00:24:50,630 We keep trying to jam it into these categories we know, 536 00:24:50,715 --> 00:24:51,803 the diseases that we know. 537 00:24:51,888 --> 00:24:54,239 But this never existed before. 538 00:24:54,487 --> 00:24:56,102 He created a new combination of genetic code. 539 00:24:56,186 --> 00:24:58,188 That means a new combination of symptoms. 540 00:24:58,273 --> 00:25:00,490 DR ANDREWS: So, we shouldn't be looking at what fits the picture, 541 00:25:00,574 --> 00:25:02,114 but at what's closest to the picture, 542 00:25:02,199 --> 00:25:04,052 so we can at least figure out a treatment. 543 00:25:04,137 --> 00:25:07,574 And what it's closest to is amyloidosis. 544 00:25:07,949 --> 00:25:10,375 This isn't an autoimmune neuropathy, 545 00:25:10,549 --> 00:25:12,899 so the nerves must be under attack by something else. 546 00:25:12,984 --> 00:25:14,984 Something like amyloid disease could leave deposits 547 00:25:15,108 --> 00:25:17,551 along the nerves, causing the symptoms we've seen. 548 00:25:17,686 --> 00:25:19,395 Where do we look for those deposits? 549 00:25:20,339 --> 00:25:21,707 The spleen. 550 00:25:28,150 --> 00:25:29,715 Drink all 8 ounces. 551 00:25:30,207 --> 00:25:32,513 We talked. We had a few laughs. 552 00:25:32,598 --> 00:25:34,474 Well, sounds date-y to me. 553 00:25:34,559 --> 00:25:35,137 [Groans] 554 00:25:35,222 --> 00:25:36,968 I don't think Enrique's a player. 555 00:25:37,053 --> 00:25:38,693 No, he's kind of the opposite of a player. 556 00:25:38,778 --> 00:25:41,137 With him, emotional connection is the point. 557 00:25:41,222 --> 00:25:43,366 He's trying to live some idealistic fantasy 558 00:25:43,451 --> 00:25:45,223 where everyone is nice and no one is jealous. 559 00:25:45,308 --> 00:25:46,804 I am so staying away. 560 00:25:46,889 --> 00:25:48,012 Well, of course. 561 00:25:48,097 --> 00:25:49,365 Once I heard "emotional connection," 562 00:25:49,449 --> 00:25:50,719 I knew the game was over. 563 00:25:50,893 --> 00:25:52,356 What does that mean? 564 00:25:52,512 --> 00:25:53,981 I'm against emotion? 565 00:25:54,097 --> 00:25:56,231 [CHUCKLES] I'm not the one with "cold-hearted bitch" 566 00:25:56,316 --> 00:25:58,076 as my social media hashtag. 567 00:25:58,161 --> 00:25:59,251 She's an excellent doctor. 568 00:25:59,336 --> 00:26:00,773 Every time you've loved somebody, 569 00:26:00,858 --> 00:26:02,418 it's ended in disappointment or death... 570 00:26:02,601 --> 00:26:03,734 Sometimes both. 571 00:26:03,819 --> 00:26:05,168 It's like a reflex now. 572 00:26:05,269 --> 00:26:08,173 You just expect that everything ends badly, so why start? 573 00:26:08,258 --> 00:26:11,833 So, despite the many practical reasons not to go out 574 00:26:11,918 --> 00:26:13,622 with a first-year, this is all about me? 575 00:26:13,707 --> 00:26:16,074 Is that a diamond ring? 576 00:26:17,093 --> 00:26:18,312 I mean, it's pretty. 577 00:26:18,397 --> 00:26:20,082 Our patient caught her fiance cheating. 578 00:26:20,167 --> 00:26:22,114 Big fight. He demanded the ring back. 579 00:26:22,199 --> 00:26:23,543 She swallowed it. 580 00:26:23,628 --> 00:26:24,683 I did. 581 00:26:24,768 --> 00:26:26,107 You don't even know if this is "going out," 582 00:26:26,191 --> 00:26:27,386 and that's the point. 583 00:26:27,471 --> 00:26:29,212 It doesn't matter what Enrique's offering. 584 00:26:29,297 --> 00:26:31,856 Whether it's friendship or romance, you're not investing. 585 00:26:31,941 --> 00:26:33,105 You're risk-averse. 586 00:26:33,190 --> 00:26:36,097 Your portfolio right now is entirely in T-Bills and money market. 587 00:26:36,182 --> 00:26:37,480 I have no idea what that means. 588 00:26:37,565 --> 00:26:39,248 And it's too bad, because a guy that can make you laugh 589 00:26:39,332 --> 00:26:41,090 might be just what you need right now. 590 00:26:41,801 --> 00:26:43,429 It's progressed to your large intestine. 591 00:26:43,514 --> 00:26:45,886 Here's a plastic bag. Put it over the toilet seat. 592 00:26:45,971 --> 00:26:48,418 You'll have every opportunity to recover your property. 593 00:26:52,068 --> 00:26:54,847 Don't run away from a chance at love. 594 00:26:56,386 --> 00:26:57,933 It's a date... 595 00:26:58,018 --> 00:26:59,152 Maybe. 596 00:26:59,328 --> 00:27:00,574 I don't know. 597 00:27:00,760 --> 00:27:02,176 Oh. 598 00:27:03,522 --> 00:27:05,219 OLIVIA: Her house is full of T.C.E., 599 00:27:05,422 --> 00:27:06,801 a side effect from chip-making 600 00:27:06,910 --> 00:27:08,668 back in Silicon Valley's early days. 601 00:27:08,753 --> 00:27:10,714 So, they move away from their toxic home, 602 00:27:10,799 --> 00:27:11,977 and hopefully things get a little better. 603 00:27:12,061 --> 00:27:13,386 Probably not much. 604 00:27:13,471 --> 00:27:15,284 She also has a genetic predisposition. 605 00:27:15,369 --> 00:27:16,949 It's both? 606 00:27:17,217 --> 00:27:19,551 She shouldn't go outside in a rainstorm. 607 00:27:20,346 --> 00:27:22,306 How do you tell a woman that her third cancer 608 00:27:22,391 --> 00:27:24,281 likely won't be close to her last? 609 00:27:27,259 --> 00:27:29,953 Unfortunately, this is a teaching moment. 610 00:27:32,609 --> 00:27:35,260 Dr. Allen, after 12 hours on duty, 611 00:27:35,345 --> 00:27:38,000 I can report that your inserts came through. 612 00:27:38,085 --> 00:27:39,898 Check your e-mail. You'll find my testimonial. 613 00:27:39,995 --> 00:27:41,223 [Exhales sharply] 614 00:27:41,308 --> 00:27:42,796 Claire. Olivia. 615 00:27:48,563 --> 00:27:50,117 [Exhales sharply] 616 00:27:50,228 --> 00:27:52,734 And if you're right, what will you do? 617 00:27:53,389 --> 00:27:55,703 We'll treat the symptoms with targeted drug therapies. 618 00:27:55,788 --> 00:27:58,396 There really isn't a disease, as such, that we can address. 619 00:27:58,543 --> 00:27:59,851 Ow. 620 00:28:05,749 --> 00:28:06,941 The pain shifted? 621 00:28:07,029 --> 00:28:09,234 Yeah. Oh. 622 00:28:09,319 --> 00:28:10,664 Never mind about the ultrasound. 623 00:28:10,749 --> 00:28:13,125 It'll be easier to check for deposits after the organ's been removed. 624 00:28:13,209 --> 00:28:14,296 - After it's... - , Yeah. 625 00:28:14,381 --> 00:28:16,804 His spleen's about to rupture. Call a transport team. 626 00:28:18,040 --> 00:28:20,434 [Alarm beeping] 627 00:28:20,608 --> 00:28:22,117 [Grunts] 628 00:28:27,562 --> 00:28:30,898 It's called Li-Fraumeni Syndrome... LFS. 629 00:28:30,999 --> 00:28:32,318 An inherited predisposition 630 00:28:32,403 --> 00:28:34,755 to developing a wide range of cancers. 631 00:28:34,983 --> 00:28:37,009 Yes, there was a toxin in your environment 632 00:28:37,094 --> 00:28:38,573 that likely played a role in this, 633 00:28:38,747 --> 00:28:41,468 but there will be other triggers in the future. 634 00:28:41,953 --> 00:28:43,448 Your body is super sensitive 635 00:28:43,533 --> 00:28:46,248 and will respond with tumors for the rest of your life. 636 00:28:53,537 --> 00:28:55,851 I know that's a shock, 637 00:28:56,216 --> 00:28:58,162 but here's what you should know... 638 00:28:58,769 --> 00:29:02,701 Most cancers are treatable if found early enough. 639 00:29:05,562 --> 00:29:08,631 We know the most common associated with LFS, 640 00:29:08,716 --> 00:29:10,716 and we can do surveillance, 641 00:29:10,865 --> 00:29:14,060 nip anything in the bud before it becomes a problem. 642 00:29:15,748 --> 00:29:19,448 It may not seem this way now, but this is good. 643 00:29:20,045 --> 00:29:21,703 We know what we're dealing with. 644 00:29:22,177 --> 00:29:25,263 We're warned, and we'll be ready. 645 00:29:32,846 --> 00:29:35,067 He won't be able to handle this. 646 00:29:39,884 --> 00:29:42,552 DR ANDREWS: Liver, pancreas, other organs look normal. 647 00:29:42,701 --> 00:29:43,769 Ah. 648 00:29:44,248 --> 00:29:47,288 But there are calcified lesions along these nerves. 649 00:29:47,373 --> 00:29:49,180 He's gonna be in pain like this for the rest of his life. 650 00:29:49,264 --> 00:29:50,107 SHAUN: No. 651 00:29:50,215 --> 00:29:52,486 There's... a reasonable chance it'll get worse 652 00:29:52,571 --> 00:29:53,746 as time goes on. 653 00:29:53,920 --> 00:29:56,146 I need my sharp-blunt curved scissors. 654 00:29:56,231 --> 00:29:58,391 ENRIQUE: What if we used CRISPR to reverse CRISPR? 655 00:29:59,916 --> 00:30:02,844 Researchers have identified a protein in certain bacteria 656 00:30:02,929 --> 00:30:04,263 that inhibits CRISPR. 657 00:30:04,863 --> 00:30:07,239 What if we insert the DNA that makes that protein 658 00:30:07,324 --> 00:30:08,500 into our patient's genome? 659 00:30:08,674 --> 00:30:10,188 That would deactivate the CRISPR gene. 660 00:30:10,273 --> 00:30:11,810 ASHER: So, CRISPR messed him up permanently, 661 00:30:11,894 --> 00:30:13,505 and you think we should do more of it? 662 00:30:13,679 --> 00:30:15,205 I don't know. Our patient is a risk-taker. 663 00:30:15,289 --> 00:30:17,030 We'd need a delivery mechanism. 664 00:30:17,204 --> 00:30:19,364 The code would have to be introduced through a virus... 665 00:30:19,511 --> 00:30:22,265 A virus that specifically targets nerves. 666 00:30:24,119 --> 00:30:25,730 Polio targets nerves. 667 00:30:25,865 --> 00:30:27,773 Because this isn't risky enough. 668 00:30:28,085 --> 00:30:29,829 Polio is such a dangerous virus 669 00:30:29,914 --> 00:30:32,437 because it's so good at penetrating the nervous system. 670 00:30:49,454 --> 00:30:50,710 Dr. Murphy? 671 00:30:54,984 --> 00:30:59,914 She's... going to be this way... Forever. 672 00:31:00,116 --> 00:31:02,945 She'll have good periods and bad periods. 673 00:31:03,119 --> 00:31:06,046 But she will always have to be on her guard. 674 00:31:06,764 --> 00:31:10,203 Is she always gonna have to be on guard against you, too? 675 00:31:10,912 --> 00:31:12,109 What does that mean? 676 00:31:12,194 --> 00:31:14,710 Chronic illness puts strain on relationships. 677 00:31:14,795 --> 00:31:18,310 Statistically, it is more often the man who can't handle it. 678 00:31:18,395 --> 00:31:20,601 Our marriage is none of your business. 679 00:31:20,702 --> 00:31:22,265 Her health is my business. 680 00:31:22,350 --> 00:31:24,539 And your behavior adds to her stress. 681 00:31:26,664 --> 00:31:30,953 You look at her, and you imagine she's gone, and that is hard. 682 00:31:31,143 --> 00:31:32,367 I get it. 683 00:31:34,154 --> 00:31:37,304 She thinks the same thing when she looks at you. 684 00:31:38,049 --> 00:31:40,546 I never complain to her. I know it's nobody's fault. 685 00:31:40,631 --> 00:31:43,398 You don't think she knows you have trouble with all this? 686 00:31:43,573 --> 00:31:45,933 Every time something new happens, 687 00:31:46,018 --> 00:31:48,934 she wonders, is this the straw 688 00:31:49,078 --> 00:31:51,320 that is gonna break your marriage? 689 00:31:52,231 --> 00:31:54,842 You've got her living in a constant state of uncertainty. 690 00:31:54,927 --> 00:31:57,671 That is practically the definition of stress. 691 00:31:59,343 --> 00:32:02,859 So, this is the "straighten up and fly right" lecture. 692 00:32:03,149 --> 00:32:04,162 No. 693 00:32:06,013 --> 00:32:07,967 I am... 694 00:32:08,837 --> 00:32:13,982 I'm telling you to consider how best to time your divorce. 695 00:32:15,103 --> 00:32:18,006 There are gonna be a lot of new issues dropping on Hannah, 696 00:32:18,194 --> 00:32:19,834 and if you're gonna end up leaving anyway, 697 00:32:19,919 --> 00:32:21,094 you should start planning now. 698 00:32:21,179 --> 00:32:22,339 I don't want to leave my wife. 699 00:32:22,424 --> 00:32:24,107 My best advice? 700 00:32:24,990 --> 00:32:28,733 Help her through this next round of treatment as best you can, 701 00:32:29,219 --> 00:32:30,803 and then get out. 702 00:32:32,057 --> 00:32:35,193 It's hard living with someone who needs so much. 703 00:32:35,478 --> 00:32:39,287 I know you feel there is a point where you have nothing left, 704 00:32:39,475 --> 00:32:41,506 where you're ready to break. 705 00:32:42,856 --> 00:32:47,732 Just... Don't break when she needs you most. 706 00:32:49,054 --> 00:32:51,178 Get out before that happens. 707 00:33:11,553 --> 00:33:13,803 Reading an article that's five years old? 708 00:33:13,888 --> 00:33:16,936 Dr. Glassman was once involved in an experimental attempt 709 00:33:17,021 --> 00:33:19,616 to treat Parkinson's with CRISPR technology. 710 00:33:19,701 --> 00:33:20,736 It failed. 711 00:33:20,821 --> 00:33:22,560 So, it's both old and it didn't work? 712 00:33:22,645 --> 00:33:25,319 Dr. Glassman likes his failures to be informative. 713 00:33:25,404 --> 00:33:27,350 That's why his articles are longer. 714 00:33:27,435 --> 00:33:30,295 Do you worry about losing the people you love? 715 00:33:35,603 --> 00:33:38,217 Because we can't stop ourselves from changing, 716 00:33:38,342 --> 00:33:40,803 which means we might stop loving someone, 717 00:33:40,888 --> 00:33:42,241 or they might stop loving us. 718 00:33:42,326 --> 00:33:44,283 It is a very bad thing. 719 00:33:45,126 --> 00:33:46,475 It is. 720 00:33:49,309 --> 00:33:53,646 So, no one can ever feel... Safe. 721 00:33:53,731 --> 00:33:57,638 How can you keep going if you never feel safe? 722 00:34:02,004 --> 00:34:04,756 Well, sometimes, not changing is just as dangerous. 723 00:34:07,471 --> 00:34:11,214 So, how do you know when to do what? 724 00:34:11,787 --> 00:34:13,592 [Chuckles] 725 00:34:13,750 --> 00:34:16,201 If you find the answer to that, let me know. 726 00:34:22,276 --> 00:34:23,717 - I have it. - You do? 727 00:34:23,802 --> 00:34:27,240 Dr. Glassman used varicella zoster virus 728 00:34:27,325 --> 00:34:29,990 as the delivery mechanism, which didn't work. 729 00:34:30,075 --> 00:34:32,053 His first choice was herpes simplex, 730 00:34:32,138 --> 00:34:33,553 but the technology was not up 731 00:34:33,638 --> 00:34:35,928 to putting their DNA package into it. 732 00:34:36,224 --> 00:34:37,902 The technology has improved. 733 00:34:37,987 --> 00:34:39,513 It can be done. 734 00:34:43,997 --> 00:34:45,363 [Grunts] 735 00:34:45,647 --> 00:34:47,358 Using conventional treatments, 736 00:34:47,443 --> 00:34:48,818 there's nothing more we can do for you. 737 00:34:48,902 --> 00:34:51,959 The pain will be permanent, and it could get worse. 738 00:34:53,394 --> 00:34:56,865 Well, I've not been one to be limited by the conventional. 739 00:34:58,035 --> 00:34:59,941 We think we can reverse the CRISPR. 740 00:35:00,026 --> 00:35:03,014 You want to reverse what I did? My telomerase change? 741 00:35:03,152 --> 00:35:04,675 They want to stop your pain. 742 00:35:04,793 --> 00:35:06,511 Soph, it's temporary. 743 00:35:06,596 --> 00:35:08,097 What is it, 40 years? 744 00:35:08,224 --> 00:35:11,113 That's nothing. Our real lives are ahead of us. 745 00:35:11,238 --> 00:35:13,316 Hey, look, as long as this doesn't kill me, 746 00:35:13,434 --> 00:35:16,418 I've made the right choice, no matter how bad things get. 747 00:35:16,639 --> 00:35:17,918 No. 748 00:35:19,793 --> 00:35:24,120 I was willing to exercise for hours and fast, 749 00:35:24,262 --> 00:35:26,543 to give up all sugar and alcohol 750 00:35:26,656 --> 00:35:29,278 and do all the other things that we needed to do 751 00:35:29,363 --> 00:35:33,058 to get to a future that I knew might never come. 752 00:35:34,228 --> 00:35:37,971 But now, you're asking me to watch you suffer 753 00:35:38,482 --> 00:35:40,144 for the rest of your life. 754 00:35:49,008 --> 00:35:52,136 You're the one who embraces change. 755 00:35:53,280 --> 00:35:58,355 So, change to the person who can be happy with me... 756 00:35:59,297 --> 00:36:00,816 Here and now. 757 00:36:09,843 --> 00:36:12,129 Doctors, would you mind waiting outside? 758 00:36:18,616 --> 00:36:20,933 Why did she want us to leave? 759 00:36:21,823 --> 00:36:23,902 I think she's delivering an ultimatum. 760 00:36:24,136 --> 00:36:26,019 [Matt berninger's one more secondplays] 761 00:36:34,110 --> 00:36:35,938 ♪♪ The last time... 762 00:36:36,730 --> 00:36:38,471 Are you sure about this? 763 00:36:39,746 --> 00:36:41,732 It seems there's always something else 764 00:36:41,817 --> 00:36:43,191 that I have to give up. 765 00:36:45,095 --> 00:36:48,347 But this isn't like sugar or cigarettes. 766 00:36:48,593 --> 00:36:50,769 You won't get over this in a hurry. 767 00:36:51,076 --> 00:36:52,285 No. 768 00:36:53,232 --> 00:36:55,004 Not in 1,000 years. 769 00:36:56,641 --> 00:37:03,474 ♪♪ And the way we talked Last night 770 00:37:04,750 --> 00:37:06,519 Are you gonna be okay? 771 00:37:06,706 --> 00:37:08,012 I'm fine. 772 00:37:08,119 --> 00:37:11,035 Alan's at work, but there should be a taxi waiting. 773 00:37:11,127 --> 00:37:14,074 I won't say goodbye, Dr. Browne, 774 00:37:14,159 --> 00:37:17,205 'cause I'll probably be seeing you again pretty soon. 775 00:37:17,842 --> 00:37:19,863 ♪♪ Baby, don't lie to me 776 00:37:19,971 --> 00:37:22,574 I sent your cab away. 777 00:37:22,739 --> 00:37:25,277 I'm sorry I wasn't here sooner. 778 00:37:25,540 --> 00:37:29,207 I had to present a proposal to my partners. 779 00:37:29,292 --> 00:37:32,644 ♪♪ Just give me A little more time 780 00:37:32,983 --> 00:37:35,550 ♪♪ Give me a little bit Of warning 781 00:37:35,644 --> 00:37:37,058 ♪♪ Baby, I'm gonna be fine 782 00:37:37,143 --> 00:37:38,871 I'm selling them my share of the business. 783 00:37:38,956 --> 00:37:42,902 ♪♪ When I figure out Where I'm going 784 00:37:43,041 --> 00:37:45,304 Is... Is there something else you want to do? 785 00:37:45,479 --> 00:37:48,286 - ♪♪ Why can't You just tell me - Yes. 786 00:37:48,371 --> 00:37:50,347 ♪♪ What you're doing here? 787 00:37:50,432 --> 00:37:51,871 I want to be your husband. 788 00:37:54,531 --> 00:37:59,796 ♪♪ Don't be cruel, If you're leaving me 789 00:37:59,881 --> 00:38:03,194 I realized I was so... 790 00:38:03,381 --> 00:38:06,944 Afraid of losing you in the future... 791 00:38:08,947 --> 00:38:10,244 I was losing you now. 792 00:38:10,329 --> 00:38:12,225 [Sniffles] 793 00:38:12,310 --> 00:38:15,577 ♪♪ Give me one more second To dry my eyes 794 00:38:15,900 --> 00:38:18,773 ♪♪ Give me one more day To realize 795 00:38:18,858 --> 00:38:22,054 ♪♪ Smoke's in our eyes Or in the distance 796 00:38:22,139 --> 00:38:24,750 ♪♪ Either way, We're gonna miss it 797 00:38:24,835 --> 00:38:27,562 ♪♪ Give me one more year To get back on track 798 00:38:27,647 --> 00:38:30,508 ♪♪ Give me one more life To win you back 799 00:38:30,593 --> 00:38:33,695 ♪♪ Smoke's in our eyes Or in the distance 800 00:38:33,780 --> 00:38:37,879 ♪♪ Either way, We're gonna miss it 801 00:38:38,186 --> 00:38:39,709 Sorry. 802 00:38:39,794 --> 00:38:42,826 I hear your VC contact decided to quit the business. 803 00:38:45,083 --> 00:38:46,709 He did the right thing. 804 00:38:51,725 --> 00:38:53,590 ♪♪ Baby, don't lie to me 805 00:38:53,764 --> 00:38:55,201 You know... 806 00:38:56,712 --> 00:38:59,014 My feet are killing me. 807 00:38:59,594 --> 00:39:02,967 ♪♪ If it ain't me, come on 808 00:39:03,086 --> 00:39:06,605 ♪♪ Just give me A little more time 809 00:39:06,690 --> 00:39:09,436 ♪♪ Give me a little bit Of warning 810 00:39:09,818 --> 00:39:12,311 ♪♪ Baby, I'm gonna be fine 811 00:39:12,452 --> 00:39:13,795 ♪♪ When I figure out where 812 00:39:13,880 --> 00:39:16,740 ♪♪ Give me one more second To dry my eyes 813 00:39:16,825 --> 00:39:19,607 ♪♪ Give me one more day To realize 814 00:39:19,701 --> 00:39:21,709 ♪♪ Smoke's in our eyes Or in the distance 815 00:39:21,794 --> 00:39:24,311 I'm open. To being friends. 816 00:39:24,428 --> 00:39:25,734 That's great. 817 00:39:25,819 --> 00:39:28,725 I'm open, too, to wherever this goes. 818 00:39:29,772 --> 00:39:31,264 It's going to friendship. 819 00:39:32,588 --> 00:39:33,975 Understood. 820 00:39:34,060 --> 00:39:35,497 But life is about change, 821 00:39:35,582 --> 00:39:37,054 which means, one day, you might change your mind. 822 00:39:37,138 --> 00:39:39,209 And if you did, I'd be open to that, too. 823 00:39:39,528 --> 00:39:41,053 It's not gonna happen. 824 00:39:44,039 --> 00:39:45,342 Okay. 825 00:39:49,605 --> 00:39:51,042 [Sighs] 826 00:40:05,905 --> 00:40:07,994 First, there should be no soap involved. 827 00:40:08,079 --> 00:40:10,037 Also, we need to stay at one end of the shower, 828 00:40:10,122 --> 00:40:13,076 so we don't accidentally knock into the temperature control. 829 00:40:13,795 --> 00:40:15,818 What changed your mind? 830 00:40:16,126 --> 00:40:18,998 I've been thinking about change over time. 831 00:40:19,188 --> 00:40:21,042 I spoke with people and also graphed 832 00:40:21,127 --> 00:40:22,490 several possibilities for us, 833 00:40:22,615 --> 00:40:24,265 using time as the horizontal axis 834 00:40:24,350 --> 00:40:25,671 and change as the vertical. 835 00:40:25,756 --> 00:40:28,709 I realized that the problem isn't really change. 836 00:40:28,794 --> 00:40:32,850 It's whether two people change in the same direction. 837 00:40:33,037 --> 00:40:35,390 We want to keep our coordinates close to each other 838 00:40:35,475 --> 00:40:37,232 for the rest of our lives. 839 00:40:38,365 --> 00:40:40,521 We certainly do. 840 00:40:40,952 --> 00:40:43,850 But people sometimes do drift apart. 841 00:40:43,935 --> 00:40:44,943 Yes. 842 00:40:45,028 --> 00:40:47,623 You need a warning when you and your partner 843 00:40:47,709 --> 00:40:49,029 might be starting to veer off, 844 00:40:49,194 --> 00:40:50,731 so you can both change course a little. 845 00:40:50,816 --> 00:40:53,116 You don't want a surprise realization when it's too late. 846 00:40:53,201 --> 00:40:54,451 Surprises are awful. 847 00:40:54,536 --> 00:40:57,522 The U.S. Army Signal Corps used flags to warn of hurricanes. 848 00:40:57,607 --> 00:40:59,053 I brought us this. 849 00:40:59,472 --> 00:41:00,888 [CHUCKLES] 850 00:41:01,131 --> 00:41:02,477 A cowbell? 851 00:41:02,624 --> 00:41:05,540 If you see us heading in different directions, 852 00:41:05,652 --> 00:41:06,811 you ring it. 853 00:41:06,940 --> 00:41:09,546 Do we really need a bell? Can't I just tell you? 854 00:41:09,631 --> 00:41:10,717 [Bell clangs] 855 00:41:10,802 --> 00:41:12,792 Oh! When you ring it, I'll pay attention. 856 00:41:12,877 --> 00:41:14,639 I really hate the sound. 857 00:41:15,381 --> 00:41:17,709 Only in emergencies. 858 00:41:18,509 --> 00:41:21,701 I've already moved the shampoo bottles. 859 00:41:22,469 --> 00:41:23,561 What? 860 00:41:23,740 --> 00:41:26,842 - ♪♪ Give me one more second to dry my eyes - Oh. 861 00:41:26,933 --> 00:41:29,803 ♪♪ Give me one more day to realize - You mean now? 862 00:41:29,982 --> 00:41:32,607 ♪♪ Smoke's in our eyes or in the distance 863 00:41:32,810 --> 00:41:35,061 Don't worry about putting the bottles back. 864 00:41:35,146 --> 00:41:36,900 - I'll do it later. - [Laughs] 865 00:41:37,428 --> 00:41:38,889 I love you. 866 00:41:39,095 --> 00:41:41,920 It's no trouble. I remember where they all go. 867 00:41:42,080 --> 00:41:44,538 ♪♪ Smoke's in our eyes or in the distance 868 00:41:44,623 --> 00:41:47,850 ♪♪ Either way, we're gonna miss it 869 00:41:48,615 --> 00:41:50,051 [car alarm beeps] 870 00:41:50,136 --> 00:41:52,948 ♪♪ Give me one more second to dry my eyes 871 00:41:53,033 --> 00:41:55,831 ♪♪ Give me one more day to realize 872 00:41:55,916 --> 00:41:58,956 ♪♪ Smoke's in our eyes or in the distance 873 00:41:59,041 --> 00:42:01,495 ♪♪ Either way, we're gonna miss it 874 00:42:01,580 --> 00:42:04,362 ♪♪ Give me one more year to get back on track 875 00:42:04,447 --> 00:42:07,194 ♪♪ Give me one more life to win you back 876 00:42:07,341 --> 00:42:10,388 ♪♪ Smoke's in our eyes or in the distance 877 00:42:10,500 --> 00:42:14,158 ♪♪ Either way, we're gonna miss it 878 00:42:15,922 --> 00:42:18,274 Synchronized by srjanapala 879 00:42:18,617 --> 00:42:19,969 ♪♪ When it's gone ♪♪ 66136

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