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1
00:00:01,764 --> 00:00:04,531
[Water running]
2
00:00:08,792 --> 00:00:09,836
[Shower door opens]
3
00:00:09,921 --> 00:00:11,140
Oh!
[Giggles]
4
00:00:16,654 --> 00:00:19,747
We can't both shower
at the same time, Lea.
5
00:00:19,832 --> 00:00:22,630
One of us would block
the steam of water for the other.
6
00:00:22,715 --> 00:00:24,989
Oh, Shaun, this is not for
the purpose of cleanliness.
7
00:00:25,074 --> 00:00:27,997
This is for the purpose
of having sex with you.
8
00:00:29,318 --> 00:00:30,724
Oh.
9
00:00:31,059 --> 00:00:32,607
N... No. No.
10
00:00:32,692 --> 00:00:35,239
It would be inconvenient,
possibly dangerous.
11
00:00:35,412 --> 00:00:37,772
Soap might get into
difficult places.
12
00:00:37,857 --> 00:00:39,201
If we leaned against
the shower handle,
13
00:00:39,285 --> 00:00:40,545
we could
scald ourselves.
14
00:00:40,630 --> 00:00:42,208
Bottles could
be disarranged.
15
00:00:43,047 --> 00:00:44,534
It was just a thought.
16
00:00:44,619 --> 00:00:46,577
It was a bad thought.
17
00:00:46,662 --> 00:00:47,607
I'm surprised.
18
00:00:47,692 --> 00:00:49,341
You're such an
intelligent person.
19
00:00:50,949 --> 00:00:53,779
I'll...
Reset your alarm.
20
00:00:57,308 --> 00:00:59,840
DR LIM: It's a three-day
weekend and a full moon.
21
00:00:59,925 --> 00:01:01,427
People are gonna do
stupid things.
22
00:01:01,512 --> 00:01:04,372
I'm asking everyone to take
an extra trauma call in the ER.
23
00:01:04,457 --> 00:01:06,445
Make yourselves available
if you're needed.
24
00:01:06,530 --> 00:01:07,950
Questions?
25
00:01:08,794 --> 00:01:10,177
How'd you get
the bruise?
26
00:01:10,274 --> 00:01:11,763
First casualty
of the full moon.
27
00:01:11,848 --> 00:01:13,202
I smacked my head
on a cupboard door
28
00:01:13,286 --> 00:01:14,554
when I was reaching
for my coffee mug.
29
00:01:14,638 --> 00:01:15,825
Any other questions?
30
00:01:15,910 --> 00:01:18,761
Why is there a Subaru
in your parking space?
31
00:01:18,846 --> 00:01:20,459
Because it's my car.
32
00:01:20,544 --> 00:01:21,544
You have a car?
33
00:01:21,645 --> 00:01:23,550
You're gonna be seeing
a lot of it. I sold the Ducati.
34
00:01:23,634 --> 00:01:24,443
What? No.
35
00:01:24,544 --> 00:01:25,739
It just
wasn't practical.
36
00:01:25,824 --> 00:01:27,029
Is it already gone?
Because...
37
00:01:27,114 --> 00:01:29,508
A guy from Craigslist
snatched it up.
38
00:01:29,637 --> 00:01:32,552
Any other questions...
Not dealing with the bike?
39
00:01:34,575 --> 00:01:36,365
It wasn't that much
of a bruise.
40
00:01:36,450 --> 00:01:37,604
[Cellphone chimes]
41
00:01:37,697 --> 00:01:39,646
But the doctor
at the ski resort told us
42
00:01:39,731 --> 00:01:41,427
I might develop
a hematoma?
43
00:01:41,557 --> 00:01:44,212
It's not unusual,
but it'll need to be drained.
44
00:01:44,566 --> 00:01:47,458
I see you were treated
for melanoma six years ago,
45
00:01:47,568 --> 00:01:49,483
and, more recently,
breast cancer.
46
00:01:49,568 --> 00:01:50,950
Hence the ski trip.
47
00:01:51,146 --> 00:01:52,552
A celebration.
48
00:01:53,266 --> 00:01:54,756
One year cancer-free.
49
00:01:54,841 --> 00:01:56,841
- Also five years cancer-free.
- [Cellphone chimes]
50
00:01:58,450 --> 00:02:02,052
I don't suppose a long needle
will be involved in this?
51
00:02:02,255 --> 00:02:04,060
Your hematoma extends
pretty deep,
52
00:02:04,145 --> 00:02:05,810
so the needle will
have to be long.
53
00:02:05,895 --> 00:02:07,380
But it's over quickly.
54
00:02:07,465 --> 00:02:09,506
Sorry, I have to intervene
before this deal goes south.
55
00:02:09,590 --> 00:02:11,513
You don't mind
if I step out?
56
00:02:12,971 --> 00:02:15,685
Would you like us to wait
for your husband to come back?
57
00:02:16,161 --> 00:02:17,458
No.
58
00:02:17,673 --> 00:02:18,958
Let's go ahead.
59
00:02:22,382 --> 00:02:24,433
DR REZNICK: How do you get
frostbite in San Jose?
60
00:02:24,518 --> 00:02:25,823
Cryotherapy accident.
61
00:02:25,908 --> 00:02:27,661
I stayed in the booth
a little too long.
62
00:02:27,746 --> 00:02:29,748
I was going to stand outside
for the full three minutes,
63
00:02:29,832 --> 00:02:31,499
- but he said...
- I said, "No need."
64
00:02:31,584 --> 00:02:33,380
I'd set the stopwatch
on my phone,
65
00:02:33,465 --> 00:02:36,009
after which, my thoughts
immediately drifted, and...
66
00:02:36,094 --> 00:02:38,747
- I came back to find him
frozen in carbonite. - [Chuckles]
67
00:02:38,832 --> 00:02:41,096
You know, I'm more worried
about the fever.
68
00:02:41,303 --> 00:02:43,162
Was the cryotherapy
meant to treat something?
69
00:02:43,247 --> 00:02:44,435
No. Routine self-care.
70
00:02:44,520 --> 00:02:46,672
We've made life extension
part of our health regime...
71
00:02:46,757 --> 00:02:49,318
Supplements, meditation,
exercise.
72
00:02:49,465 --> 00:02:51,271
Three of my gaming apps
have gone viral.
73
00:02:51,356 --> 00:02:54,194
I'm lucky enough to afford
basically whatever I want,
74
00:02:54,279 --> 00:02:55,943
so I spend it
on my health.
75
00:02:56,294 --> 00:02:59,443
No, I figure fever,
must be an infection.
76
00:02:59,708 --> 00:03:02,802
Well, I know that frostbite
can make you vulnerable.
77
00:03:02,887 --> 00:03:07,325
It just... It didn't seem
severe enough to...
78
00:03:07,695 --> 00:03:10,099
Oh, sorry.
I feel a little queasy.
79
00:03:10,288 --> 00:03:11,332
Aah!
80
00:03:11,417 --> 00:03:12,497
Wyatt.
81
00:03:12,598 --> 00:03:13,732
Ow!
82
00:03:19,993 --> 00:03:21,646
[Beeping]
83
00:03:21,970 --> 00:03:23,716
I need a medical
transport team, stat.
84
00:03:23,804 --> 00:03:25,719
Perforated bowel.
He needs immediate surgery.
85
00:03:26,057 --> 00:03:27,404
Theme music playing...
86
00:03:27,488 --> 00:03:29,488
*THE GOOD DOCTOR*
Season 04 Episode 07
87
00:03:29,695 --> 00:03:31,871
Episode Title: "The Uncertainty Principle"
Aired on: January 18, 2021
88
00:03:32,056 --> 00:03:34,114
Synchronized by srjanapala
89
00:03:35,793 --> 00:03:38,129
No. No. Why do people hate
wind farms?
90
00:03:38,214 --> 00:03:39,982
Everyone thinks
they're noisy.
91
00:03:40,228 --> 00:03:41,802
This could make a turbine
sound as quiet
92
00:03:41,887 --> 00:03:43,338
as a page turning
in a library.
93
00:03:43,423 --> 00:03:44,833
That's not worth
our investing in?
94
00:03:44,918 --> 00:03:46,326
Did you even look...
Hold on.
95
00:03:46,469 --> 00:03:48,122
Anything I
need to know?
96
00:03:48,210 --> 00:03:49,380
Hematoma's drained.
97
00:03:49,465 --> 00:03:51,304
We're sending a sample
to Pathology... Routine.
98
00:03:51,388 --> 00:03:52,739
Should have it back
sometime tomorrow.
99
00:03:52,823 --> 00:03:54,310
- Thank you.
- Mm-hmm.
100
00:03:55,008 --> 00:03:57,044
I couldn't help
overhearing a little.
101
00:03:57,536 --> 00:03:59,411
Are you
a venture capitalist?
102
00:04:00,414 --> 00:04:02,490
The only people who ask me
if I'm a VC
103
00:04:02,575 --> 00:04:05,232
are people who want a VC
to invest in their project.
104
00:04:06,976 --> 00:04:10,951
Maybe, after we get your wife
healthy again, we could talk?
105
00:04:11,059 --> 00:04:12,209
Call whenever
you're ready.
106
00:04:12,294 --> 00:04:13,966
My life is listening
to ideas.
107
00:04:14,051 --> 00:04:15,437
If it's good, I'll run it
by my two partners.
108
00:04:15,521 --> 00:04:16,341
If it's really good,
109
00:04:16,426 --> 00:04:18,794
we'll take a 30% equity
position in your company.
110
00:04:20,921 --> 00:04:22,083
Yeah.
111
00:04:22,168 --> 00:04:25,060
Yeah, you're the one who wanted
us to get into clean technology.
112
00:04:26,896 --> 00:04:29,021
I think I've been asked out
on a date.
113
00:04:30,293 --> 00:04:31,724
Nice.
114
00:04:31,904 --> 00:04:33,107
No, I work with him.
115
00:04:33,192 --> 00:04:34,927
Hasn't stopped you before.
I supervise him.
116
00:04:35,012 --> 00:04:36,110
Schedules can be changed.
117
00:04:36,195 --> 00:04:37,936
He's polyamorous.
118
00:04:38,615 --> 00:04:40,896
Unless he also texted you
a ring, it's just a date.
119
00:04:40,981 --> 00:04:42,560
And you need to
get out more.
120
00:04:43,711 --> 00:04:45,029
So do I.
121
00:04:47,661 --> 00:04:48,880
[Gloves snap]
122
00:04:51,273 --> 00:04:53,747
DR ANDREWS: You want to
take down the splenocolic ligament.
123
00:04:54,060 --> 00:04:56,889
Just don't nick the
inferior mesenteric artery.
124
00:04:57,118 --> 00:05:00,731
ASHER: I feel the I.M.A.
under my finger.
125
00:05:00,888 --> 00:05:02,890
Placing the stapler.
126
00:05:03,287 --> 00:05:04,872
And cutting.
127
00:05:05,658 --> 00:05:07,240
I voted "approve."
128
00:05:09,883 --> 00:05:11,363
Disapprove.
129
00:05:11,607 --> 00:05:12,999
No opinion.
130
00:05:13,220 --> 00:05:14,220
There's a poll?
131
00:05:14,345 --> 00:05:16,724
Yes...
About shower sex.
132
00:05:16,809 --> 00:05:19,458
I know it's wrong
to discuss shower sex at work,
133
00:05:19,543 --> 00:05:21,055
so I did a poll instead.
134
00:05:21,276 --> 00:05:22,497
Much better.
135
00:05:22,582 --> 00:05:25,108
Dr. Murphy, do you really
want people knowing the details
136
00:05:25,193 --> 00:05:26,482
of your personal life?
137
00:05:26,567 --> 00:05:29,872
You don't think they took it
as an abstract question?
138
00:05:29,957 --> 00:05:32,841
No. We all take it as something
that happened between you and Lea.
139
00:05:32,926 --> 00:05:34,083
And that
there was a fight.
140
00:05:34,168 --> 00:05:35,678
DR PARK: Sometime before
8:00 a.m. today,
141
00:05:35,762 --> 00:05:37,763
which was when the poll
was sent out.
142
00:05:38,974 --> 00:05:40,889
You are very astute.
143
00:05:40,974 --> 00:05:44,328
I'm seeing diffuse dilation
of the large bowel here.
144
00:05:44,452 --> 00:05:45,919
Is that normal?
145
00:05:46,564 --> 00:05:49,255
Some calcified lesions.
146
00:05:49,838 --> 00:05:51,361
Wall's thin, too.
147
00:05:51,446 --> 00:05:52,630
Hirschsprung's.
148
00:05:52,715 --> 00:05:54,553
I thought Hirschsprung's
was a disease only babies
149
00:05:54,637 --> 00:05:55,644
and young children got.
150
00:05:55,729 --> 00:05:56,943
It is.
151
00:05:57,643 --> 00:05:59,060
But he has it.
152
00:06:06,269 --> 00:06:07,878
We treated the Hirschsprung's
153
00:06:07,963 --> 00:06:10,035
by removing the dilated part
of your colon.
154
00:06:10,120 --> 00:06:11,842
It won't impact your life,
155
00:06:11,927 --> 00:06:13,590
but we would like
an explanation.
156
00:06:13,675 --> 00:06:14,841
DR PARK:
Dr. Murphy doesn't mean
157
00:06:14,925 --> 00:06:16,512
we expect you
to be a diagnostician.
158
00:06:16,597 --> 00:06:17,777
It's just...
159
00:06:17,902 --> 00:06:19,456
This was
kind of singular.
160
00:06:19,722 --> 00:06:22,143
So, if you have
any thoughts...
161
00:06:22,228 --> 00:06:25,589
Did anyone in your family
suddenly develop these symptoms?
162
00:06:28,709 --> 00:06:32,620
I did something singular to
myself about six months ago.
163
00:06:33,144 --> 00:06:35,058
I modified
my genetic code.
164
00:06:35,429 --> 00:06:38,246
I did a CRISPR procedure under
the guidance of some researchers
165
00:06:38,331 --> 00:06:39,652
I know in China
through my work.
166
00:06:39,737 --> 00:06:41,488
They put together
a series of cocktails.
167
00:06:41,573 --> 00:06:45,887
They FedExed them to be, and
Sophie helped me inject them
168
00:06:45,972 --> 00:06:47,098
into my bone marrow.
169
00:06:47,183 --> 00:06:48,268
Why?
170
00:06:48,442 --> 00:06:49,957
If you know anything
about CRISPR,
171
00:06:50,042 --> 00:06:52,006
you know how risky it is
to tinker with your genome.
172
00:06:52,090 --> 00:06:54,711
You have no idea what problems
you might let loose.
173
00:06:54,796 --> 00:06:57,308
I needed to optimize
my telomerase activity.
174
00:06:57,425 --> 00:06:58,997
It's the enzyme responsible
for correcting
175
00:06:59,081 --> 00:07:00,121
cell replication errors,
176
00:07:00,206 --> 00:07:01,228
essentially,
the cause of aging.
177
00:07:01,312 --> 00:07:02,487
SHAWN: You can't stop aging
178
00:07:02,572 --> 00:07:04,698
through changing
your telomerase activity.
179
00:07:04,783 --> 00:07:08,285
You might extend your life
a little, but exercise...
180
00:07:08,370 --> 00:07:10,910
It does the same thing.
Much less risky.
181
00:07:10,995 --> 00:07:12,440
Your decision
makes no sense.
182
00:07:12,525 --> 00:07:15,854
Extending my life by a few
years is only my short-term goal.
183
00:07:16,023 --> 00:07:17,981
Look, you know how fast
medicine is moving.
184
00:07:18,066 --> 00:07:19,940
The day isn't that far away
when cloning
185
00:07:20,025 --> 00:07:22,945
will make transplants as easy
as switching out a light socket.
186
00:07:23,030 --> 00:07:24,816
AI will start
to make breakthroughs
187
00:07:24,901 --> 00:07:26,424
that we can't predict
or understand.
188
00:07:26,536 --> 00:07:29,479
Medical knowledge
will rise exponentially.
189
00:07:29,564 --> 00:07:32,191
There are babies born now
who could live to see it,
190
00:07:32,276 --> 00:07:34,292
could live to be
1,000 years old.
191
00:07:34,423 --> 00:07:36,173
Maybe more.
Maybe forever.
192
00:07:36,267 --> 00:07:38,530
Or at least,
as long as they want to.
193
00:07:38,698 --> 00:07:40,980
So, our plan is to give
my CRISPR a year
194
00:07:41,065 --> 00:07:43,077
to make sure the telomerase
change works,
195
00:07:43,162 --> 00:07:45,307
and then
we'll do her.
196
00:07:47,135 --> 00:07:49,267
We'll aspirate a sample
of your bone marrow.
197
00:07:49,352 --> 00:07:51,192
See if we can figure out
what the hell you did.
198
00:07:53,103 --> 00:07:54,440
[Elevator bell dings]
199
00:07:58,523 --> 00:07:59,741
Hey.
200
00:07:59,826 --> 00:08:03,830
Um... I don't think coffee's
a good idea.
201
00:08:04,375 --> 00:08:06,203
Entire civilizations
rely on it.
202
00:08:06,290 --> 00:08:08,215
But I don't think you're
referring to the beverage itself.
203
00:08:08,299 --> 00:08:10,089
I don't think it's
a good idea for first-years
204
00:08:10,173 --> 00:08:11,346
and fourth-years
to go out.
205
00:08:11,431 --> 00:08:14,474
I am bound to supervise you
at some point in the future,
206
00:08:14,559 --> 00:08:17,565
and it'd get complicated
trying to change dates out,
207
00:08:17,650 --> 00:08:20,291
and the fact is...
208
00:08:20,514 --> 00:08:23,649
Seeing somebody you work with
rarely ends happily.
209
00:08:23,734 --> 00:08:24,955
- So, I appreciate
- Oh, you
210
00:08:25,040 --> 00:08:27,200
- you thinking of me, but I...
- thought it was a date.
211
00:08:28,848 --> 00:08:30,838
I'm still new here,
and I thought it was
212
00:08:30,924 --> 00:08:33,463
a good opportunity to get
to know each other.
213
00:08:33,836 --> 00:08:36,072
Coffee's perfect
because you're asking
214
00:08:36,157 --> 00:08:38,508
the least amount of commitment
from another human being.
215
00:08:38,845 --> 00:08:40,471
It's not even lunch.
216
00:08:40,956 --> 00:08:42,915
If it's still a "no,"
it's still a "no,"
217
00:08:43,143 --> 00:08:45,010
but I'll let you
re-think your answer.
218
00:08:58,909 --> 00:09:01,477
He only claimed it
wasn't a date to save face.
219
00:09:01,690 --> 00:09:03,823
Or maybe I just assumed.
220
00:09:04,131 --> 00:09:05,417
But why did I assume?
221
00:09:05,502 --> 00:09:07,513
I don't think I'm
some kind of narcissist
222
00:09:07,598 --> 00:09:10,193
who thinks every man
wants to get close to me.
223
00:09:10,705 --> 00:09:14,005
Or we both assumed it's a date
because it's a date.
224
00:09:14,224 --> 00:09:16,185
This is fun.
I like being your bestie.
225
00:09:16,270 --> 00:09:17,583
Slumber party?
226
00:09:21,104 --> 00:09:22,768
[Door opens]
227
00:09:23,615 --> 00:09:26,459
I made a poll to test
the popularity of shower sex.
228
00:09:26,544 --> 00:09:27,775
I heard.
229
00:09:27,860 --> 00:09:29,906
I fielded some questions
about that.
230
00:09:29,991 --> 00:09:34,487
"Approve" has won, but
don't get too excited, Lea.
231
00:09:34,572 --> 00:09:36,900
It's only 58-38,
232
00:09:36,985 --> 00:09:39,291
with several
complicated noncommittals,
233
00:09:39,395 --> 00:09:41,814
so clearly my attitude
is reasonable.
234
00:09:41,939 --> 00:09:43,893
We don't have room
for a...
235
00:09:43,978 --> 00:09:46,252
Skier exercise thing.
236
00:09:46,383 --> 00:09:49,331
I'm only putting it together
so I can take a picture
237
00:09:49,416 --> 00:09:50,713
and sell it online.
238
00:09:50,798 --> 00:09:52,783
Why do you have it
if you don't want it?
239
00:09:58,822 --> 00:10:01,463
My ex sent it.
240
00:10:02,562 --> 00:10:04,042
"Ex"?
241
00:10:04,268 --> 00:10:05,979
Husband.
242
00:10:07,744 --> 00:10:09,144
I left this thing
in the attic
243
00:10:09,229 --> 00:10:11,338
until I got settled somewhere
with enough space.
244
00:10:11,423 --> 00:10:13,244
And okay,
that was 10 years ago,
245
00:10:13,400 --> 00:10:15,346
but it's not like
it was in his way.
246
00:10:18,625 --> 00:10:22,907
We got married, not for long,
right out of high school.
247
00:10:22,992 --> 00:10:24,578
Literally
the boy next door.
248
00:10:24,696 --> 00:10:26,742
We grew up together.
People expected it.
249
00:10:26,827 --> 00:10:29,922
It... Was a big mistake.
250
00:10:30,007 --> 00:10:32,391
We both realized it
pretty quickly.
251
00:10:36,678 --> 00:10:38,758
ENRIQUE: Why would you even
want to live forever?
252
00:10:38,844 --> 00:10:40,391
You'd be bored
out of your mind.
253
00:10:40,476 --> 00:10:41,290
[Chuckles]
254
00:10:41,375 --> 00:10:42,751
The person I am now
255
00:10:42,836 --> 00:10:46,750
is... miles away from the person
I was at 14.
256
00:10:47,516 --> 00:10:49,687
I only get more distant
every year.
257
00:10:50,721 --> 00:10:54,336
You learn to
understand,
258
00:10:55,252 --> 00:10:57,976
love books that
you once hated,
259
00:10:59,028 --> 00:11:01,734
sometimes people
you once hated.
260
00:11:01,907 --> 00:11:06,259
Music that you didn't get
the point of becomes magical.
261
00:11:06,731 --> 00:11:08,690
And a thousand new doors
will open.
262
00:11:08,775 --> 00:11:11,082
I look forward
to the adventure.
263
00:11:11,336 --> 00:11:12,492
[NEEDLE SQUELCHES]Ow.
264
00:11:12,577 --> 00:11:15,430
Sorry. Adventure's not always
gonna be fun.
265
00:11:16,555 --> 00:11:20,182
I figure it takes
40 or 50 years
266
00:11:20,267 --> 00:11:22,586
just to get over
the things your parents did.
267
00:11:22,731 --> 00:11:24,341
If only we lived
long enough,
268
00:11:24,426 --> 00:11:28,492
the human race might finally
have a chance to grow up.
269
00:11:35,283 --> 00:11:37,242
What size shoes
do you wear?
270
00:11:37,374 --> 00:11:39,133
Seven and a half.
271
00:11:39,815 --> 00:11:42,062
"Dr. Allen's Walking On Clouds
Inserts."
272
00:11:42,147 --> 00:11:44,517
Putting "doctor" in the name is
always good marketing strategy.
273
00:11:44,601 --> 00:11:47,082
They're designed
to reduce inflammation
274
00:11:47,555 --> 00:11:49,209
that could lead to
plantar fasciitis,
275
00:11:49,383 --> 00:11:52,342
calluses, arthritis,
and they feel damn good.
276
00:11:52,516 --> 00:11:53,996
Does this have anything
to do with our patient's
277
00:11:54,080 --> 00:11:55,356
venture capitalist
husband?
278
00:11:55,441 --> 00:11:56,869
I need testimonials.
279
00:11:56,954 --> 00:11:58,402
Labs and Path
for Hannah Palmer.
280
00:12:01,572 --> 00:12:04,206
Aren't we all busy enough
learning how to be surgeons?
281
00:12:04,674 --> 00:12:07,230
Do you really want to divide
your focus onto something trivial?
282
00:12:12,139 --> 00:12:15,394
Because wanting to make money
taints the purity of medicine?
283
00:12:17,044 --> 00:12:18,785
I have five brothers.
284
00:12:18,870 --> 00:12:21,133
I've been taking care
of people my whole life.
285
00:12:21,248 --> 00:12:24,556
Someone got hurt, they came
to me to patch them up.
286
00:12:24,863 --> 00:12:27,956
I became a doctor
so I could get paid for it,
287
00:12:28,104 --> 00:12:31,128
but also because I'm good
at taking care of people.
288
00:12:31,349 --> 00:12:33,824
It's possible to do something
for more than one reason.
289
00:12:44,986 --> 00:12:46,613
The news is bad.
290
00:12:55,728 --> 00:12:59,089
There's an abnormally
healthy population
291
00:12:59,174 --> 00:13:02,097
of hematopoietic progenitor
stem cells.
292
00:13:02,262 --> 00:13:04,331
- He did it?
- It's significant.
293
00:13:04,416 --> 00:13:07,608
He's succeeded in optimizing
enough telomerase activity
294
00:13:07,693 --> 00:13:10,144
to potentially add 10 years
to his natural life.
295
00:13:10,229 --> 00:13:12,550
DR ANDREWS: Well, assuming it
doesn't subtract about 50.
296
00:13:12,635 --> 00:13:14,284
There's already
an autoimmune reaction
297
00:13:14,369 --> 00:13:15,452
- that mimics
- Hirschsprung's.
298
00:13:15,536 --> 00:13:16,605
Who knows what else
he did?
299
00:13:16,699 --> 00:13:19,105
What if this is the opposite
of an auto-immune condition?
300
00:13:19,190 --> 00:13:20,452
What if
he's done something
301
00:13:20,537 --> 00:13:22,284
that lowers his resistance
to infection?
302
00:13:22,369 --> 00:13:24,800
Then we'd be seeing
more opportunistic infections
303
00:13:24,885 --> 00:13:26,060
of the lungs and skin.
304
00:13:26,239 --> 00:13:28,003
If you lived
another 1,000 years,
305
00:13:28,088 --> 00:13:30,313
would you be with
the same person at the end
306
00:13:30,397 --> 00:13:31,550
as at the beginning?
307
00:13:31,650 --> 00:13:32,956
- No.
- No.
308
00:13:33,890 --> 00:13:35,500
No, if you assume
monogamy.
309
00:13:35,585 --> 00:13:37,504
I mean, that puts too much
strain on a relationship.
310
00:13:37,588 --> 00:13:39,606
Is one person supposed to
be everything to another,
311
00:13:39,691 --> 00:13:41,304
all the time,
for 1,000 years?
312
00:13:41,389 --> 00:13:45,156
Apparently Jesus agrees.
On monogamy.
313
00:13:45,241 --> 00:13:47,632
He said that, in Heaven,
there'll be no more marriages.
314
00:13:47,717 --> 00:13:50,953
I guess humans can't sustain
a relationship that long.
315
00:13:51,092 --> 00:13:52,332
You read
the New Testament, too?
316
00:13:52,417 --> 00:13:54,843
And the Qur'an.
And other things.
317
00:13:54,928 --> 00:13:56,211
It's like
you're a stalker.
318
00:13:56,296 --> 00:13:58,603
It's like you and God had
an acrimonious divorce.
319
00:13:58,794 --> 00:14:02,242
What if he caused
neurofibromatosis?
320
00:14:02,362 --> 00:14:04,640
Microscopic tumors forming
on the nerve sheath?
321
00:14:04,725 --> 00:14:06,273
Mm. Possible,
but there'd have been
322
00:14:06,358 --> 00:14:07,665
some evidence
of Schwann cell growth
323
00:14:07,749 --> 00:14:08,851
around his colon.
324
00:14:08,936 --> 00:14:11,437
Would you still love your wife
in 1,000 years?
325
00:14:13,423 --> 00:14:15,469
You have three answers.
That should be enough.
326
00:14:15,569 --> 00:14:18,000
Park's marriage failed
in far less time,
327
00:14:18,085 --> 00:14:19,390
and Enrique
doesn't even try.
328
00:14:19,475 --> 00:14:20,955
Asher is an...
329
00:14:21,106 --> 00:14:22,542
Unknown quantity.
330
00:14:22,663 --> 00:14:23,778
You're committed.
331
00:14:23,863 --> 00:14:25,732
You've made promises.
332
00:14:27,917 --> 00:14:30,061
I've made promises
based on
333
00:14:30,177 --> 00:14:33,271
an understood
human life-span, Murphy.
334
00:14:33,893 --> 00:14:36,998
Most likely diagnosis is
autoimmune polyneuropathy.
335
00:14:37,117 --> 00:14:38,679
It damaged the enteral
ganglion nerve
336
00:14:38,764 --> 00:14:39,951
and led to
the perforations.
337
00:14:40,036 --> 00:14:42,389
Start him on steroids
and immunosuppressants.
338
00:14:42,855 --> 00:14:44,073
Dr. Andrews.
339
00:14:44,158 --> 00:14:46,204
So, you wouldn't
have gotten married
340
00:14:46,289 --> 00:14:47,986
if you thought
it would be forever.
341
00:14:48,071 --> 00:14:50,699
You expect all relationships
to fail over time.
342
00:14:50,784 --> 00:14:52,920
It's just a question
of how long?
343
00:14:54,288 --> 00:14:55,967
I love her now.
344
00:14:56,604 --> 00:15:00,045
I intend to love her
as long as I live.
345
00:15:01,006 --> 00:15:05,553
But, eventually,
everything breaks.
346
00:15:14,391 --> 00:15:15,701
I always go back
to comfort reading
347
00:15:15,785 --> 00:15:16,920
when I'm in
the hospital.
348
00:15:17,005 --> 00:15:18,998
Cozy mysteries
in little English villages,
349
00:15:19,083 --> 00:15:21,660
where nothing bad happens
to anyone we like.
350
00:15:23,132 --> 00:15:24,777
We've gotten
your results back.
351
00:15:24,925 --> 00:15:26,210
When will
your husband be...
352
00:15:26,295 --> 00:15:27,730
Is it cancer?
353
00:15:29,833 --> 00:15:31,183
Yes.
354
00:15:33,109 --> 00:15:34,800
Thyroid carcinoma.
355
00:15:35,566 --> 00:15:37,574
We're gonna do
a complete imaging series
356
00:15:37,666 --> 00:15:38,745
to pinpoint
just how advanced...
357
00:15:38,829 --> 00:15:40,066
Treatment?
358
00:15:40,742 --> 00:15:44,034
Surgery to remove some or all
of your thyroid
359
00:15:44,119 --> 00:15:46,382
is usually the first line
of defense.
360
00:15:46,501 --> 00:15:49,329
Sometimes, we can wait,
but given the hematoma
361
00:15:49,414 --> 00:15:53,089
was probably caused by the
tumor invading nearby vasculatures,
362
00:15:53,285 --> 00:15:55,632
- we should probably do it
in the next few days. - [Wheezes]
363
00:15:55,716 --> 00:15:58,738
Later, there'll be radioactive
iodine treatment...
364
00:15:58,929 --> 00:16:00,355
[Wheezes]
365
00:16:00,533 --> 00:16:01,449
Panic attack?
366
00:16:01,534 --> 00:16:04,222
[Wheezing]
367
00:16:07,458 --> 00:16:09,199
Her trachea's deviated
to the right.
368
00:16:09,284 --> 00:16:11,496
The tumor's compressing it.
We're doing surgery now.
369
00:16:11,674 --> 00:16:14,041
[Groaning]
370
00:16:15,441 --> 00:16:18,183
[Monitor beeping]
371
00:16:22,522 --> 00:16:24,307
What happened?
The nurse just said "surgery."
372
00:16:24,392 --> 00:16:26,010
Was it the hematoma?
373
00:16:26,886 --> 00:16:27,974
It's more serious.
374
00:16:29,925 --> 00:16:32,101
It... It's not cancer...
375
00:16:32,573 --> 00:16:34,018
Again.
376
00:16:34,329 --> 00:16:36,128
Thyroid carcinoma.
377
00:16:37,150 --> 00:16:39,892
We've removed her thyroid.
She's doing well.
378
00:16:40,114 --> 00:16:41,784
We're looking into
potential causes...
379
00:16:41,948 --> 00:16:43,761
Genetic, environmental.
380
00:16:43,846 --> 00:16:47,823
There may be a deeper issue
that we can find and address.
381
00:16:57,874 --> 00:16:59,514
I can't do this.
382
00:17:01,660 --> 00:17:03,350
You've done it before.
383
00:17:04,458 --> 00:17:06,154
You'll do it
this time.
384
00:17:11,857 --> 00:17:13,670
Do you know
what it's like...
385
00:17:14,405 --> 00:17:16,147
To wake up every morning
and know your wife
386
00:17:16,240 --> 00:17:18,006
might not be here
next year?
387
00:17:19,618 --> 00:17:22,694
All those treatments...
388
00:17:22,932 --> 00:17:26,442
They all... They all have this
little tag attached to them
389
00:17:26,527 --> 00:17:29,487
that says,
"Because she might die."
390
00:17:30,014 --> 00:17:33,264
And you see them
put those gloves on
391
00:17:33,495 --> 00:17:34,544
before they hook up
the chemo.
392
00:17:34,628 --> 00:17:36,108
You know why
they do that.
393
00:17:37,493 --> 00:17:39,053
It's because
it's poison.
394
00:17:41,519 --> 00:17:43,350
And you sit there...
395
00:17:44,563 --> 00:17:47,522
And you watch them shove
poison into the person you love.
396
00:17:48,185 --> 00:17:49,631
And why?
397
00:17:51,289 --> 00:17:53,131
Because she might die.
398
00:17:55,857 --> 00:17:58,561
We're killing her
because she might die.
399
00:18:03,213 --> 00:18:04,670
Go for a run.
400
00:18:05,115 --> 00:18:06,740
Go punch a wall.
401
00:18:07,262 --> 00:18:08,902
You need to release
some endorphins.
402
00:18:08,987 --> 00:18:10,423
My release is my job.
403
00:18:10,990 --> 00:18:12,601
That's why I love it.
404
00:18:12,775 --> 00:18:15,647
My work requires
total focus.
405
00:18:15,732 --> 00:18:16,907
And every minute
I'm working
406
00:18:16,992 --> 00:18:19,161
is a minute
I'm not thinking about...
407
00:18:19,748 --> 00:18:21,231
Losing her.
408
00:18:26,318 --> 00:18:27,674
I have to go.
409
00:18:33,673 --> 00:18:37,078
Your pain and weakness are
consistent with polyneuropathy,
410
00:18:37,163 --> 00:18:39,596
treatable with steroids
and immunosuppressants.
411
00:18:39,703 --> 00:18:42,815
If you live 1,000 years,
will you still love Sophie?
412
00:18:45,285 --> 00:18:46,460
Yes.
413
00:18:46,545 --> 00:18:48,329
How can you be sure?
414
00:18:48,420 --> 00:18:50,901
People change.
You expect to change.
415
00:18:51,447 --> 00:18:54,166
Sophie and I
will change together.
416
00:18:54,356 --> 00:18:55,636
We'll go through
the same adventures
417
00:18:55,720 --> 00:18:56,764
and learn
the same lessons.
418
00:18:56,849 --> 00:18:59,089
What if you go through
the same adventures
419
00:18:59,174 --> 00:19:00,800
and learn
different lessons?
420
00:19:00,885 --> 00:19:03,933
Even if we did, whoever,
whatever we become,
421
00:19:04,018 --> 00:19:05,644
Sophie will always
be beautiful.
422
00:19:05,729 --> 00:19:08,363
I mean, she could turn into
a machine or a set of pixels
423
00:19:08,448 --> 00:19:11,339
or a giant purple flower,
and she'll still be beautiful,
424
00:19:11,424 --> 00:19:14,261
because it's part of
her essential nature.
425
00:19:17,329 --> 00:19:20,042
But if you don't know
how you'll change,
426
00:19:20,233 --> 00:19:21,670
you don't know
how you'll change.
427
00:19:21,755 --> 00:19:23,274
Shaun.
428
00:19:24,253 --> 00:19:25,515
We'll let you
get some rest.
429
00:19:25,611 --> 00:19:28,066
The steroids should make you
feel a lot better.
430
00:19:34,357 --> 00:19:38,425
Why didn't you ever mention
you had an ex-husband?
431
00:19:39,076 --> 00:19:42,949
Shaun, I've barely
thought about him in years.
432
00:19:43,272 --> 00:19:46,754
I didn't mention him
because he's not important.
433
00:19:47,217 --> 00:19:49,925
I know.
That's the problem.
434
00:19:50,256 --> 00:19:53,259
At one time, you felt he was
important enough to your life
435
00:19:53,344 --> 00:19:56,521
to marry him, and now
you barely think of him.
436
00:19:56,963 --> 00:20:00,706
You make long-term plans,
you have expectations,
437
00:20:00,796 --> 00:20:02,493
and then something
happens to you,
438
00:20:02,578 --> 00:20:05,277
and suddenly you're
a different person.
439
00:20:06,628 --> 00:20:11,146
I know you don't like change,
but it's not all bad.
440
00:20:11,820 --> 00:20:16,129
After all, you are working to
change yourself all the time.
441
00:20:16,311 --> 00:20:22,261
I'm working to be a better
surgeon, a better boyfriend,
442
00:20:22,346 --> 00:20:24,918
better at the things
I've chosen,
443
00:20:25,003 --> 00:20:26,316
but this...
444
00:20:26,401 --> 00:20:28,183
Other change...
It's unpredictable.
445
00:20:28,300 --> 00:20:29,174
You don't choose it.
446
00:20:29,259 --> 00:20:31,097
It just comes at you.
447
00:20:31,342 --> 00:20:34,144
Oh, it's like hurricanes
before 1873,
448
00:20:34,229 --> 00:20:36,231
when the Army Signal Corps
first put up flags
449
00:20:36,316 --> 00:20:37,706
to warn people
storms were coming.
450
00:20:37,791 --> 00:20:40,480
Before that, houses were
flattened, lives destroyed,
451
00:20:40,565 --> 00:20:42,722
and there was no way to see
it was heading for you.
452
00:20:42,941 --> 00:20:44,183
Shaun.
453
00:20:45,005 --> 00:20:48,526
Our relationship will not end
in natural disaster.
454
00:20:48,867 --> 00:20:50,259
It did begin in one.
455
00:20:52,707 --> 00:20:55,492
I'm going to look in
on my patient.
456
00:20:56,183 --> 00:20:57,750
Okay.
457
00:21:04,507 --> 00:21:07,771
Blood and saliva will tell us
if there's a genetic cause,
458
00:21:08,172 --> 00:21:09,925
and the samples
we take from your house
459
00:21:10,042 --> 00:21:12,206
will tell us if there's
something environmental.
460
00:21:13,879 --> 00:21:16,347
I know it's s... Stupid.
461
00:21:17,529 --> 00:21:20,065
I've almost felt guilty
for my cancer,
462
00:21:20,150 --> 00:21:24,573
like I... arbitrarily decided
to be sick and burdensome.
463
00:21:26,877 --> 00:21:28,347
Do the people
you're close to
464
00:21:28,432 --> 00:21:31,105
ever act like
you're a burden to them?
465
00:21:31,190 --> 00:21:32,451
You mean Alan.
466
00:21:34,716 --> 00:21:36,401
He's scared.
467
00:21:36,684 --> 00:21:40,557
He takes the exit he's got
and he turns to his work.
468
00:21:41,067 --> 00:21:42,286
You're okay with that?
469
00:21:50,303 --> 00:21:52,707
I accept this compromise.
470
00:21:52,792 --> 00:21:53,840
That's not the hard part.
471
00:21:53,925 --> 00:21:55,323
The hard part is...
472
00:21:55,962 --> 00:21:57,401
Not knowing.
473
00:21:59,034 --> 00:22:02,511
Each new thing that happens,
I worry, "Is this it?
474
00:22:03,729 --> 00:22:05,776
"Is this where
I lose him?
475
00:22:06,836 --> 00:22:08,636
"Is this where
he breaks?"
476
00:22:16,025 --> 00:22:18,097
CLAIRE: So, this is
boiled coffee.
477
00:22:18,318 --> 00:22:20,253
Some people call it
"Turkish coffee,"
478
00:22:20,338 --> 00:22:23,211
or "Greek coffee,"
or "Egyptian coffee"...
479
00:22:23,306 --> 00:22:24,529
Because we need to
take ownership
480
00:22:24,613 --> 00:22:25,899
and put things
in categories.
481
00:22:25,984 --> 00:22:27,323
Yeah.
482
00:22:27,782 --> 00:22:29,436
You actually live
in this thing,
483
00:22:29,536 --> 00:22:31,451
in the hospital
parking garage?
484
00:22:31,621 --> 00:22:32,621
Why not?
485
00:22:32,706 --> 00:22:34,055
Convenient for work.
486
00:22:34,140 --> 00:22:36,540
When I want to spend a
few days off the beaten track,
487
00:22:36,625 --> 00:22:38,407
it's convenient
for that, too.
488
00:22:38,671 --> 00:22:41,457
Ooh. I'm gonna get
three sips in this.
489
00:22:41,584 --> 00:22:43,516
But three
really great sips.
490
00:22:45,295 --> 00:22:47,079
That's how I try
to live my life...
491
00:22:47,308 --> 00:22:51,558
Try to appreciate, savor,
not pass by.
492
00:22:54,427 --> 00:22:56,785
Is that what
the polyamory is about?
493
00:22:57,770 --> 00:23:00,598
Does it really work, or is it
one of those theories about life
494
00:23:00,683 --> 00:23:02,206
that people
regret later?
495
00:23:02,348 --> 00:23:03,567
No regrets so far.
496
00:23:03,652 --> 00:23:05,262
Mm-hmm.
No, I guess not.
497
00:23:05,347 --> 00:23:08,263
Not while you're young
and having fun.
498
00:23:08,499 --> 00:23:09,587
It is fun,
499
00:23:09,847 --> 00:23:11,595
but not for the reasons
that you're thinking.
500
00:23:11,679 --> 00:23:13,425
It isn't about sex.
501
00:23:13,879 --> 00:23:16,816
It's about commitment,
emotional connection.
502
00:23:16,901 --> 00:23:19,152
The joy I'm sure you get
out of a relationship,
503
00:23:19,237 --> 00:23:20,238
I get a little more.
504
00:23:20,323 --> 00:23:22,412
Also, I have to give
a little more.
505
00:23:22,505 --> 00:23:24,594
But that's meaningful,
too.
506
00:23:25,425 --> 00:23:26,667
Hmm.
507
00:23:27,621 --> 00:23:29,231
Do you mind if I
ask you something,
508
00:23:29,316 --> 00:23:31,105
since we're
getting personal?
509
00:23:34,794 --> 00:23:36,261
Sure.
510
00:23:36,903 --> 00:23:38,687
What's your favorite
misheard song lyric?
511
00:23:40,338 --> 00:23:42,688
[Laughs]
512
00:23:47,415 --> 00:23:48,861
This is nice.
513
00:23:50,979 --> 00:23:53,372
I'm glad it's
not a date.
514
00:23:53,468 --> 00:23:54,948
Me, too.
515
00:23:55,033 --> 00:23:56,579
I don't believe
in those categories.
516
00:24:00,845 --> 00:24:02,055
[MACHINE BEEPING]
517
00:24:02,140 --> 00:24:03,095
He reported widespread
518
00:24:03,180 --> 00:24:03,923
bilateral pain,
519
00:24:04,039 --> 00:24:04,868
then he keeled over.
520
00:24:04,953 --> 00:24:06,391
B.P. dropped to 80
over palp.
521
00:24:06,476 --> 00:24:07,564
I'll order a vasopressor.
522
00:24:07,649 --> 00:24:08,662
Already did.Good.
523
00:24:08,747 --> 00:24:12,599
We need an EKG, CBC, and chest
images, and a new diagnosis.
524
00:24:12,693 --> 00:24:15,217
Whatever he caused with
CRISPR, it's not just neuropathy.
525
00:24:15,532 --> 00:24:17,216
Something else
is killing him.
526
00:24:23,630 --> 00:24:25,327
What if he's caused something
that mimics
527
00:24:25,412 --> 00:24:26,505
carcinomatous
autonomic neuropathy?
528
00:24:26,589 --> 00:24:29,731
It explains the B.P.
and bowel issue.
529
00:24:29,973 --> 00:24:32,973
That doesn't explain the sensory
issue that led to the frostbite.
530
00:24:36,192 --> 00:24:37,779
A connective
tissue disorder?
531
00:24:37,864 --> 00:24:39,263
That would have shown up
on the scans.
532
00:24:39,347 --> 00:24:40,919
His chest looks normal.
533
00:24:45,785 --> 00:24:47,201
Maybe we can't think
of the answer
534
00:24:47,286 --> 00:24:48,268
because there is
no answer.
535
00:24:48,353 --> 00:24:50,630
We keep trying to jam it
into these categories we know,
536
00:24:50,715 --> 00:24:51,803
the diseases
that we know.
537
00:24:51,888 --> 00:24:54,239
But this never
existed before.
538
00:24:54,487 --> 00:24:56,102
He created a new combination
of genetic code.
539
00:24:56,186 --> 00:24:58,188
That means a new combination
of symptoms.
540
00:24:58,273 --> 00:25:00,490
DR ANDREWS: So, we shouldn't
be looking at what fits the picture,
541
00:25:00,574 --> 00:25:02,114
but at what's closest to
the picture,
542
00:25:02,199 --> 00:25:04,052
so we can at least
figure out a treatment.
543
00:25:04,137 --> 00:25:07,574
And what it's closest to
is amyloidosis.
544
00:25:07,949 --> 00:25:10,375
This isn't
an autoimmune neuropathy,
545
00:25:10,549 --> 00:25:12,899
so the nerves must be under
attack by something else.
546
00:25:12,984 --> 00:25:14,984
Something like amyloid disease
could leave deposits
547
00:25:15,108 --> 00:25:17,551
along the nerves, causing
the symptoms we've seen.
548
00:25:17,686 --> 00:25:19,395
Where do we look
for those deposits?
549
00:25:20,339 --> 00:25:21,707
The spleen.
550
00:25:28,150 --> 00:25:29,715
Drink all 8 ounces.
551
00:25:30,207 --> 00:25:32,513
We talked.
We had a few laughs.
552
00:25:32,598 --> 00:25:34,474
Well,
sounds date-y to me.
553
00:25:34,559 --> 00:25:35,137
[Groans]
554
00:25:35,222 --> 00:25:36,968
I don't think Enrique's
a player.
555
00:25:37,053 --> 00:25:38,693
No, he's kind of the opposite
of a player.
556
00:25:38,778 --> 00:25:41,137
With him, emotional connection
is the point.
557
00:25:41,222 --> 00:25:43,366
He's trying to live
some idealistic fantasy
558
00:25:43,451 --> 00:25:45,223
where everyone is nice
and no one is jealous.
559
00:25:45,308 --> 00:25:46,804
I am so staying away.
560
00:25:46,889 --> 00:25:48,012
Well, of course.
561
00:25:48,097 --> 00:25:49,365
Once I heard
"emotional connection,"
562
00:25:49,449 --> 00:25:50,719
I knew the game was over.
563
00:25:50,893 --> 00:25:52,356
What does that mean?
564
00:25:52,512 --> 00:25:53,981
I'm against emotion?
565
00:25:54,097 --> 00:25:56,231
[CHUCKLES] I'm not the one
with "cold-hearted bitch"
566
00:25:56,316 --> 00:25:58,076
as my social media hashtag.
567
00:25:58,161 --> 00:25:59,251
She's an
excellent doctor.
568
00:25:59,336 --> 00:26:00,773
Every time
you've loved somebody,
569
00:26:00,858 --> 00:26:02,418
it's ended in disappointment
or death...
570
00:26:02,601 --> 00:26:03,734
Sometimes both.
571
00:26:03,819 --> 00:26:05,168
It's like a reflex now.
572
00:26:05,269 --> 00:26:08,173
You just expect that everything
ends badly, so why start?
573
00:26:08,258 --> 00:26:11,833
So, despite the many
practical reasons not to go out
574
00:26:11,918 --> 00:26:13,622
with a first-year,
this is all about me?
575
00:26:13,707 --> 00:26:16,074
Is that a diamond ring?
576
00:26:17,093 --> 00:26:18,312
I mean, it's pretty.
577
00:26:18,397 --> 00:26:20,082
Our patient caught
her fiance cheating.
578
00:26:20,167 --> 00:26:22,114
Big fight.
He demanded the ring back.
579
00:26:22,199 --> 00:26:23,543
She swallowed it.
580
00:26:23,628 --> 00:26:24,683
I did.
581
00:26:24,768 --> 00:26:26,107
You don't even know
if this is "going out,"
582
00:26:26,191 --> 00:26:27,386
and that's the point.
583
00:26:27,471 --> 00:26:29,212
It doesn't matter
what Enrique's offering.
584
00:26:29,297 --> 00:26:31,856
Whether it's friendship or
romance, you're not investing.
585
00:26:31,941 --> 00:26:33,105
You're risk-averse.
586
00:26:33,190 --> 00:26:36,097
Your portfolio right now is entirely
in T-Bills and money market.
587
00:26:36,182 --> 00:26:37,480
I have no idea
what that means.
588
00:26:37,565 --> 00:26:39,248
And it's too bad, because a
guy that can make you laugh
589
00:26:39,332 --> 00:26:41,090
might be just what you need
right now.
590
00:26:41,801 --> 00:26:43,429
It's progressed to
your large intestine.
591
00:26:43,514 --> 00:26:45,886
Here's a plastic bag.
Put it over the toilet seat.
592
00:26:45,971 --> 00:26:48,418
You'll have every opportunity
to recover your property.
593
00:26:52,068 --> 00:26:54,847
Don't run away
from a chance at love.
594
00:26:56,386 --> 00:26:57,933
It's a date...
595
00:26:58,018 --> 00:26:59,152
Maybe.
596
00:26:59,328 --> 00:27:00,574
I don't know.
597
00:27:00,760 --> 00:27:02,176
Oh.
598
00:27:03,522 --> 00:27:05,219
OLIVIA: Her house
is full of T.C.E.,
599
00:27:05,422 --> 00:27:06,801
a side effect
from chip-making
600
00:27:06,910 --> 00:27:08,668
back in Silicon Valley's
early days.
601
00:27:08,753 --> 00:27:10,714
So, they move away
from their toxic home,
602
00:27:10,799 --> 00:27:11,977
and hopefully
things get a little better.
603
00:27:12,061 --> 00:27:13,386
Probably not much.
604
00:27:13,471 --> 00:27:15,284
She also has a genetic
predisposition.
605
00:27:15,369 --> 00:27:16,949
It's both?
606
00:27:17,217 --> 00:27:19,551
She shouldn't go outside
in a rainstorm.
607
00:27:20,346 --> 00:27:22,306
How do you tell a woman
that her third cancer
608
00:27:22,391 --> 00:27:24,281
likely won't be close
to her last?
609
00:27:27,259 --> 00:27:29,953
Unfortunately,
this is a teaching moment.
610
00:27:32,609 --> 00:27:35,260
Dr. Allen,
after 12 hours on duty,
611
00:27:35,345 --> 00:27:38,000
I can report that
your inserts came through.
612
00:27:38,085 --> 00:27:39,898
Check your e-mail.
You'll find my testimonial.
613
00:27:39,995 --> 00:27:41,223
[Exhales sharply]
614
00:27:41,308 --> 00:27:42,796
Claire. Olivia.
615
00:27:48,563 --> 00:27:50,117
[Exhales sharply]
616
00:27:50,228 --> 00:27:52,734
And if you're right,
what will you do?
617
00:27:53,389 --> 00:27:55,703
We'll treat the symptoms
with targeted drug therapies.
618
00:27:55,788 --> 00:27:58,396
There really isn't a disease,
as such, that we can address.
619
00:27:58,543 --> 00:27:59,851
Ow.
620
00:28:05,749 --> 00:28:06,941
The pain shifted?
621
00:28:07,029 --> 00:28:09,234
Yeah.
Oh.
622
00:28:09,319 --> 00:28:10,664
Never mind about
the ultrasound.
623
00:28:10,749 --> 00:28:13,125
It'll be easier to check for deposits
after the organ's been removed.
624
00:28:13,209 --> 00:28:14,296
- After it's...
- , Yeah.
625
00:28:14,381 --> 00:28:16,804
His spleen's about to rupture.
Call a transport team.
626
00:28:18,040 --> 00:28:20,434
[Alarm beeping]
627
00:28:20,608 --> 00:28:22,117
[Grunts]
628
00:28:27,562 --> 00:28:30,898
It's called
Li-Fraumeni Syndrome... LFS.
629
00:28:30,999 --> 00:28:32,318
An inherited
predisposition
630
00:28:32,403 --> 00:28:34,755
to developing a wide range
of cancers.
631
00:28:34,983 --> 00:28:37,009
Yes, there was a toxin
in your environment
632
00:28:37,094 --> 00:28:38,573
that likely played a role
in this,
633
00:28:38,747 --> 00:28:41,468
but there will be other
triggers in the future.
634
00:28:41,953 --> 00:28:43,448
Your body
is super sensitive
635
00:28:43,533 --> 00:28:46,248
and will respond with tumors
for the rest of your life.
636
00:28:53,537 --> 00:28:55,851
I know that's a shock,
637
00:28:56,216 --> 00:28:58,162
but here's what
you should know...
638
00:28:58,769 --> 00:29:02,701
Most cancers are treatable
if found early enough.
639
00:29:05,562 --> 00:29:08,631
We know the most common
associated with LFS,
640
00:29:08,716 --> 00:29:10,716
and we can
do surveillance,
641
00:29:10,865 --> 00:29:14,060
nip anything in the bud
before it becomes a problem.
642
00:29:15,748 --> 00:29:19,448
It may not seem this way now,
but this is good.
643
00:29:20,045 --> 00:29:21,703
We know what
we're dealing with.
644
00:29:22,177 --> 00:29:25,263
We're warned,
and we'll be ready.
645
00:29:32,846 --> 00:29:35,067
He won't be able
to handle this.
646
00:29:39,884 --> 00:29:42,552
DR ANDREWS: Liver, pancreas,
other organs look normal.
647
00:29:42,701 --> 00:29:43,769
Ah.
648
00:29:44,248 --> 00:29:47,288
But there are calcified
lesions along these nerves.
649
00:29:47,373 --> 00:29:49,180
He's gonna be in pain like
this for the rest of his life.
650
00:29:49,264 --> 00:29:50,107
SHAUN: No.
651
00:29:50,215 --> 00:29:52,486
There's... a reasonable chance
it'll get worse
652
00:29:52,571 --> 00:29:53,746
as time goes on.
653
00:29:53,920 --> 00:29:56,146
I need my sharp-blunt
curved scissors.
654
00:29:56,231 --> 00:29:58,391
ENRIQUE: What if we used
CRISPR to reverse CRISPR?
655
00:29:59,916 --> 00:30:02,844
Researchers have identified
a protein in certain bacteria
656
00:30:02,929 --> 00:30:04,263
that inhibits CRISPR.
657
00:30:04,863 --> 00:30:07,239
What if we insert the DNA
that makes that protein
658
00:30:07,324 --> 00:30:08,500
into our
patient's genome?
659
00:30:08,674 --> 00:30:10,188
That would deactivate
the CRISPR gene.
660
00:30:10,273 --> 00:30:11,810
ASHER: So, CRISPR messed
him up permanently,
661
00:30:11,894 --> 00:30:13,505
and you think we should
do more of it?
662
00:30:13,679 --> 00:30:15,205
I don't know.
Our patient is a risk-taker.
663
00:30:15,289 --> 00:30:17,030
We'd need
a delivery mechanism.
664
00:30:17,204 --> 00:30:19,364
The code would have to be
introduced through a virus...
665
00:30:19,511 --> 00:30:22,265
A virus that specifically
targets nerves.
666
00:30:24,119 --> 00:30:25,730
Polio targets nerves.
667
00:30:25,865 --> 00:30:27,773
Because this isn't
risky enough.
668
00:30:28,085 --> 00:30:29,829
Polio is such
a dangerous virus
669
00:30:29,914 --> 00:30:32,437
because it's so good at
penetrating the nervous system.
670
00:30:49,454 --> 00:30:50,710
Dr. Murphy?
671
00:30:54,984 --> 00:30:59,914
She's... going to be
this way... Forever.
672
00:31:00,116 --> 00:31:02,945
She'll have good periods
and bad periods.
673
00:31:03,119 --> 00:31:06,046
But she will always
have to be on her guard.
674
00:31:06,764 --> 00:31:10,203
Is she always gonna have to be
on guard against you, too?
675
00:31:10,912 --> 00:31:12,109
What does that mean?
676
00:31:12,194 --> 00:31:14,710
Chronic illness puts strain
on relationships.
677
00:31:14,795 --> 00:31:18,310
Statistically, it is more often
the man who can't handle it.
678
00:31:18,395 --> 00:31:20,601
Our marriage is none
of your business.
679
00:31:20,702 --> 00:31:22,265
Her health
is my business.
680
00:31:22,350 --> 00:31:24,539
And your behavior
adds to her stress.
681
00:31:26,664 --> 00:31:30,953
You look at her, and you imagine
she's gone, and that is hard.
682
00:31:31,143 --> 00:31:32,367
I get it.
683
00:31:34,154 --> 00:31:37,304
She thinks the same thing
when she looks at you.
684
00:31:38,049 --> 00:31:40,546
I never complain to her.
I know it's nobody's fault.
685
00:31:40,631 --> 00:31:43,398
You don't think she knows you
have trouble with all this?
686
00:31:43,573 --> 00:31:45,933
Every time
something new happens,
687
00:31:46,018 --> 00:31:48,934
she wonders,
is this the straw
688
00:31:49,078 --> 00:31:51,320
that is gonna break
your marriage?
689
00:31:52,231 --> 00:31:54,842
You've got her living in a
constant state of uncertainty.
690
00:31:54,927 --> 00:31:57,671
That is practically
the definition of stress.
691
00:31:59,343 --> 00:32:02,859
So, this is the "straighten up
and fly right" lecture.
692
00:32:03,149 --> 00:32:04,162
No.
693
00:32:06,013 --> 00:32:07,967
I am...
694
00:32:08,837 --> 00:32:13,982
I'm telling you to consider
how best to time your divorce.
695
00:32:15,103 --> 00:32:18,006
There are gonna be a lot of
new issues dropping on Hannah,
696
00:32:18,194 --> 00:32:19,834
and if you're gonna end up
leaving anyway,
697
00:32:19,919 --> 00:32:21,094
you should start
planning now.
698
00:32:21,179 --> 00:32:22,339
I don't want to leave
my wife.
699
00:32:22,424 --> 00:32:24,107
My best advice?
700
00:32:24,990 --> 00:32:28,733
Help her through this next round
of treatment as best you can,
701
00:32:29,219 --> 00:32:30,803
and then get out.
702
00:32:32,057 --> 00:32:35,193
It's hard living with someone
who needs so much.
703
00:32:35,478 --> 00:32:39,287
I know you feel there is a point
where you have nothing left,
704
00:32:39,475 --> 00:32:41,506
where you're ready
to break.
705
00:32:42,856 --> 00:32:47,732
Just... Don't break
when she needs you most.
706
00:32:49,054 --> 00:32:51,178
Get out
before that happens.
707
00:33:11,553 --> 00:33:13,803
Reading an article
that's five years old?
708
00:33:13,888 --> 00:33:16,936
Dr. Glassman was once involved
in an experimental attempt
709
00:33:17,021 --> 00:33:19,616
to treat Parkinson's
with CRISPR technology.
710
00:33:19,701 --> 00:33:20,736
It failed.
711
00:33:20,821 --> 00:33:22,560
So, it's both old
and it didn't work?
712
00:33:22,645 --> 00:33:25,319
Dr. Glassman likes
his failures to be informative.
713
00:33:25,404 --> 00:33:27,350
That's why his articles
are longer.
714
00:33:27,435 --> 00:33:30,295
Do you worry about losing
the people you love?
715
00:33:35,603 --> 00:33:38,217
Because we can't stop
ourselves from changing,
716
00:33:38,342 --> 00:33:40,803
which means we might
stop loving someone,
717
00:33:40,888 --> 00:33:42,241
or they might stop
loving us.
718
00:33:42,326 --> 00:33:44,283
It is a very bad thing.
719
00:33:45,126 --> 00:33:46,475
It is.
720
00:33:49,309 --> 00:33:53,646
So, no one can
ever feel... Safe.
721
00:33:53,731 --> 00:33:57,638
How can you keep going
if you never feel safe?
722
00:34:02,004 --> 00:34:04,756
Well, sometimes, not changing
is just as dangerous.
723
00:34:07,471 --> 00:34:11,214
So, how do you know
when to do what?
724
00:34:11,787 --> 00:34:13,592
[Chuckles]
725
00:34:13,750 --> 00:34:16,201
If you find the answer
to that, let me know.
726
00:34:22,276 --> 00:34:23,717
- I have it.
- You do?
727
00:34:23,802 --> 00:34:27,240
Dr. Glassman used
varicella zoster virus
728
00:34:27,325 --> 00:34:29,990
as the delivery mechanism,
which didn't work.
729
00:34:30,075 --> 00:34:32,053
His first choice
was herpes simplex,
730
00:34:32,138 --> 00:34:33,553
but the technology
was not up
731
00:34:33,638 --> 00:34:35,928
to putting their DNA package
into it.
732
00:34:36,224 --> 00:34:37,902
The technology
has improved.
733
00:34:37,987 --> 00:34:39,513
It can be done.
734
00:34:43,997 --> 00:34:45,363
[Grunts]
735
00:34:45,647 --> 00:34:47,358
Using conventional
treatments,
736
00:34:47,443 --> 00:34:48,818
there's nothing more
we can do for you.
737
00:34:48,902 --> 00:34:51,959
The pain will be permanent,
and it could get worse.
738
00:34:53,394 --> 00:34:56,865
Well, I've not been one to be
limited by the conventional.
739
00:34:58,035 --> 00:34:59,941
We think we can reverse
the CRISPR.
740
00:35:00,026 --> 00:35:03,014
You want to reverse what I did?
My telomerase change?
741
00:35:03,152 --> 00:35:04,675
They want to
stop your pain.
742
00:35:04,793 --> 00:35:06,511
Soph, it's temporary.
743
00:35:06,596 --> 00:35:08,097
What is it, 40 years?
744
00:35:08,224 --> 00:35:11,113
That's nothing.
Our real lives are ahead of us.
745
00:35:11,238 --> 00:35:13,316
Hey, look, as long as this
doesn't kill me,
746
00:35:13,434 --> 00:35:16,418
I've made the right choice,
no matter how bad things get.
747
00:35:16,639 --> 00:35:17,918
No.
748
00:35:19,793 --> 00:35:24,120
I was willing to exercise
for hours and fast,
749
00:35:24,262 --> 00:35:26,543
to give up all sugar
and alcohol
750
00:35:26,656 --> 00:35:29,278
and do all the other things
that we needed to do
751
00:35:29,363 --> 00:35:33,058
to get to a future that I knew
might never come.
752
00:35:34,228 --> 00:35:37,971
But now, you're asking me
to watch you suffer
753
00:35:38,482 --> 00:35:40,144
for the rest
of your life.
754
00:35:49,008 --> 00:35:52,136
You're the one
who embraces change.
755
00:35:53,280 --> 00:35:58,355
So, change to the person
who can be happy with me...
756
00:35:59,297 --> 00:36:00,816
Here and now.
757
00:36:09,843 --> 00:36:12,129
Doctors, would you mind
waiting outside?
758
00:36:18,616 --> 00:36:20,933
Why did she want us
to leave?
759
00:36:21,823 --> 00:36:23,902
I think she's delivering
an ultimatum.
760
00:36:24,136 --> 00:36:26,019
[Matt berninger's
one more secondplays]
761
00:36:34,110 --> 00:36:35,938
♪♪ The last time...
762
00:36:36,730 --> 00:36:38,471
Are you sure
about this?
763
00:36:39,746 --> 00:36:41,732
It seems there's always
something else
764
00:36:41,817 --> 00:36:43,191
that I have to give up.
765
00:36:45,095 --> 00:36:48,347
But this isn't like sugar
or cigarettes.
766
00:36:48,593 --> 00:36:50,769
You won't get over this
in a hurry.
767
00:36:51,076 --> 00:36:52,285
No.
768
00:36:53,232 --> 00:36:55,004
Not in 1,000 years.
769
00:36:56,641 --> 00:37:03,474
♪♪ And the way we talked
Last night
770
00:37:04,750 --> 00:37:06,519
Are you gonna
be okay?
771
00:37:06,706 --> 00:37:08,012
I'm fine.
772
00:37:08,119 --> 00:37:11,035
Alan's at work, but there
should be a taxi waiting.
773
00:37:11,127 --> 00:37:14,074
I won't say goodbye,
Dr. Browne,
774
00:37:14,159 --> 00:37:17,205
'cause I'll probably be
seeing you again pretty soon.
775
00:37:17,842 --> 00:37:19,863
♪♪ Baby, don't lie to me
776
00:37:19,971 --> 00:37:22,574
I sent your cab away.
777
00:37:22,739 --> 00:37:25,277
I'm sorry
I wasn't here sooner.
778
00:37:25,540 --> 00:37:29,207
I had to present a proposal
to my partners.
779
00:37:29,292 --> 00:37:32,644
♪♪ Just give me
A little more time
780
00:37:32,983 --> 00:37:35,550
♪♪ Give me a little bit
Of warning
781
00:37:35,644 --> 00:37:37,058
♪♪ Baby, I'm gonna be fine
782
00:37:37,143 --> 00:37:38,871
I'm selling them my share
of the business.
783
00:37:38,956 --> 00:37:42,902
♪♪ When I figure out
Where I'm going
784
00:37:43,041 --> 00:37:45,304
Is... Is there something else
you want to do?
785
00:37:45,479 --> 00:37:48,286
- ♪♪ Why can't You just tell me
- Yes.
786
00:37:48,371 --> 00:37:50,347
♪♪ What you're doing here?
787
00:37:50,432 --> 00:37:51,871
I want to be
your husband.
788
00:37:54,531 --> 00:37:59,796
♪♪ Don't be cruel,
If you're leaving me
789
00:37:59,881 --> 00:38:03,194
I realized I was so...
790
00:38:03,381 --> 00:38:06,944
Afraid of losing you
in the future...
791
00:38:08,947 --> 00:38:10,244
I was losing you now.
792
00:38:10,329 --> 00:38:12,225
[Sniffles]
793
00:38:12,310 --> 00:38:15,577
♪♪ Give me one more second
To dry my eyes
794
00:38:15,900 --> 00:38:18,773
♪♪ Give me one more day
To realize
795
00:38:18,858 --> 00:38:22,054
♪♪ Smoke's in our eyes
Or in the distance
796
00:38:22,139 --> 00:38:24,750
♪♪ Either way,
We're gonna miss it
797
00:38:24,835 --> 00:38:27,562
♪♪ Give me one more year
To get back on track
798
00:38:27,647 --> 00:38:30,508
♪♪ Give me one more life
To win you back
799
00:38:30,593 --> 00:38:33,695
♪♪ Smoke's in our eyes
Or in the distance
800
00:38:33,780 --> 00:38:37,879
♪♪ Either way,
We're gonna miss it
801
00:38:38,186 --> 00:38:39,709
Sorry.
802
00:38:39,794 --> 00:38:42,826
I hear your VC contact
decided to quit the business.
803
00:38:45,083 --> 00:38:46,709
He did the right thing.
804
00:38:51,725 --> 00:38:53,590
♪♪ Baby, don't lie to me
805
00:38:53,764 --> 00:38:55,201
You know...
806
00:38:56,712 --> 00:38:59,014
My feet
are killing me.
807
00:38:59,594 --> 00:39:02,967
♪♪ If it ain't me, come on
808
00:39:03,086 --> 00:39:06,605
♪♪ Just give me
A little more time
809
00:39:06,690 --> 00:39:09,436
♪♪ Give me a little bit
Of warning
810
00:39:09,818 --> 00:39:12,311
♪♪ Baby, I'm gonna be fine
811
00:39:12,452 --> 00:39:13,795
♪♪ When I figure out where
812
00:39:13,880 --> 00:39:16,740
♪♪ Give me one more second
To dry my eyes
813
00:39:16,825 --> 00:39:19,607
♪♪ Give me one more day
To realize
814
00:39:19,701 --> 00:39:21,709
♪♪ Smoke's in our eyes
Or in the distance
815
00:39:21,794 --> 00:39:24,311
I'm open.
To being friends.
816
00:39:24,428 --> 00:39:25,734
That's great.
817
00:39:25,819 --> 00:39:28,725
I'm open, too,
to wherever this goes.
818
00:39:29,772 --> 00:39:31,264
It's going
to friendship.
819
00:39:32,588 --> 00:39:33,975
Understood.
820
00:39:34,060 --> 00:39:35,497
But life is
about change,
821
00:39:35,582 --> 00:39:37,054
which means, one day,
you might change your mind.
822
00:39:37,138 --> 00:39:39,209
And if you did,
I'd be open to that, too.
823
00:39:39,528 --> 00:39:41,053
It's not gonna happen.
824
00:39:44,039 --> 00:39:45,342
Okay.
825
00:39:49,605 --> 00:39:51,042
[Sighs]
826
00:40:05,905 --> 00:40:07,994
First, there should be
no soap involved.
827
00:40:08,079 --> 00:40:10,037
Also, we need to stay
at one end of the shower,
828
00:40:10,122 --> 00:40:13,076
so we don't accidentally knock
into the temperature control.
829
00:40:13,795 --> 00:40:15,818
What changed
your mind?
830
00:40:16,126 --> 00:40:18,998
I've been thinking about
change over time.
831
00:40:19,188 --> 00:40:21,042
I spoke with people
and also graphed
832
00:40:21,127 --> 00:40:22,490
several possibilities
for us,
833
00:40:22,615 --> 00:40:24,265
using time as
the horizontal axis
834
00:40:24,350 --> 00:40:25,671
and change as
the vertical.
835
00:40:25,756 --> 00:40:28,709
I realized that the problem
isn't really change.
836
00:40:28,794 --> 00:40:32,850
It's whether two people change
in the same direction.
837
00:40:33,037 --> 00:40:35,390
We want to keep our
coordinates close to each other
838
00:40:35,475 --> 00:40:37,232
for the rest
of our lives.
839
00:40:38,365 --> 00:40:40,521
We certainly do.
840
00:40:40,952 --> 00:40:43,850
But people sometimes
do drift apart.
841
00:40:43,935 --> 00:40:44,943
Yes.
842
00:40:45,028 --> 00:40:47,623
You need a warning
when you and your partner
843
00:40:47,709 --> 00:40:49,029
might be starting
to veer off,
844
00:40:49,194 --> 00:40:50,731
so you can both
change course a little.
845
00:40:50,816 --> 00:40:53,116
You don't want a surprise
realization when it's too late.
846
00:40:53,201 --> 00:40:54,451
Surprises are awful.
847
00:40:54,536 --> 00:40:57,522
The U.S. Army Signal Corps
used flags to warn of hurricanes.
848
00:40:57,607 --> 00:40:59,053
I brought us this.
849
00:40:59,472 --> 00:41:00,888
[CHUCKLES]
850
00:41:01,131 --> 00:41:02,477
A cowbell?
851
00:41:02,624 --> 00:41:05,540
If you see us heading
in different directions,
852
00:41:05,652 --> 00:41:06,811
you ring it.
853
00:41:06,940 --> 00:41:09,546
Do we really need a bell?
Can't I just tell you?
854
00:41:09,631 --> 00:41:10,717
[Bell clangs]
855
00:41:10,802 --> 00:41:12,792
Oh! When you ring it,
I'll pay attention.
856
00:41:12,877 --> 00:41:14,639
I really hate
the sound.
857
00:41:15,381 --> 00:41:17,709
Only in emergencies.
858
00:41:18,509 --> 00:41:21,701
I've already moved
the shampoo bottles.
859
00:41:22,469 --> 00:41:23,561
What?
860
00:41:23,740 --> 00:41:26,842
- ♪♪ Give me one more second
to dry my eyes - Oh.
861
00:41:26,933 --> 00:41:29,803
♪♪ Give me one more day
to realize - You mean now?
862
00:41:29,982 --> 00:41:32,607
♪♪ Smoke's in our eyes
or in the distance
863
00:41:32,810 --> 00:41:35,061
Don't worry about putting
the bottles back.
864
00:41:35,146 --> 00:41:36,900
- I'll do it later.
- [Laughs]
865
00:41:37,428 --> 00:41:38,889
I love you.
866
00:41:39,095 --> 00:41:41,920
It's no trouble.
I remember where they all go.
867
00:41:42,080 --> 00:41:44,538
♪♪ Smoke's in our eyes
or in the distance
868
00:41:44,623 --> 00:41:47,850
♪♪ Either way,
we're gonna miss it
869
00:41:48,615 --> 00:41:50,051
[car alarm beeps]
870
00:41:50,136 --> 00:41:52,948
♪♪ Give me one more second
to dry my eyes
871
00:41:53,033 --> 00:41:55,831
♪♪ Give me one more day
to realize
872
00:41:55,916 --> 00:41:58,956
♪♪ Smoke's in our eyes
or in the distance
873
00:41:59,041 --> 00:42:01,495
♪♪ Either way,
we're gonna miss it
874
00:42:01,580 --> 00:42:04,362
♪♪ Give me one more year
to get back on track
875
00:42:04,447 --> 00:42:07,194
♪♪ Give me one more life
to win you back
876
00:42:07,341 --> 00:42:10,388
♪♪ Smoke's in our eyes
or in the distance
877
00:42:10,500 --> 00:42:14,158
♪♪ Either way,
we're gonna miss it
878
00:42:15,922 --> 00:42:18,274
Synchronized by srjanapala
879
00:42:18,617 --> 00:42:19,969
♪♪ When it's gone ♪♪
66136
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