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okay hi everybody i just wanted to do
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another couple short videos
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and please excuse the occasional
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white rings that's the in my glasses i
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can't seem to figure out how to get
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rid of that and still have lighting i
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not
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some sort of cyborg who has white rings
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on my eyes that's just um anyways
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i can't quite get rid of it i hope it's
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not too distracting
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uh what i wanted to talk about today
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pretty briefly
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was uh first the pcr
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test and then i wanted to review the
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latest
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research on the medurna vaccine
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so they'll be broken up into two
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segments
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so let's uh do the first one on the pcr
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test and we've gone over this
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a number of times but i still get
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questions and i think it's one of the
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most important things to understand
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particularly because there was a recent
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ruling i think by
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some court system in portugal i'm not
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sure if it was the supreme court or some
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court
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us questioning the validity of the pcr
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test
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and they actually ruled that the pcr
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test was not
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a valid diagnostic tool which of course
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it's not
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a pcr test is a manufacturing tool
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so let me start by saying uh one of the
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most discouraging
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things that's uh arisen in this whole
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situation since march and this probably
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happened around
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april or so i got an email from
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one of the leaders in the uh so-called
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anti-vaccine movement
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head of one of the major physicians
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organizations
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and the email was uh something to the
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effect of tom i just wanted you to be
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aware
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that um there's a pcr test available
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that has a 84.6
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percent accuracy which she said was
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better than some of the other ones
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and then i should consider using it
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so of course i wrote back and said uh
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thank you very much for the information
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but i would never
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use a test that has anything less than
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an 84.7 percent accuracy
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and of course i was kidding uh to make a
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point
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but uh the interesting question is how
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did
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how did she think these people came up
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with a number 84.6
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although i must admit it could have been
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86.4
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because i don't remember but it's one of
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those two in any case
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it was 84 86 point
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something four or six so the question is
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how did they come up with that
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test sorry how did they come up with
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that number
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so here is the way you could come up
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with the number
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a pcr test is what's called a surrogate
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test
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which means it's not a direct
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measurement of anything
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it's a stand in for the direct
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measurement
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and let me give you a very clear example
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of how
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you know the false positive and false
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negative rate for a surrogate test
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imagine you wanted to do a blood
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pregnancy test
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and you wanted to see how accurate it is
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so one the first thing you could do is
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take 100 women
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who are 20 weeks pregnant now
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the first question is are you a hundred
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percent sure that all those hundred
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women
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are in fact pregnant and i think most of
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us
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if not hopefully all of us would agree
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that you could do that
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you could feel the baby you could feel
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if the baby's kicking
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you could do an ultrasound and see if
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there's actually a baby
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in there you might even actually ask the
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woman do you think there's a baby in
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there which is not 100
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accurate but it's i guess it would be
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pretty close
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and if you were also sort of stupid
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enough you could do an x-ray and see the
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baby
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i hope nobody would do that but there
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are a number of ways
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that you could convince yourself that we
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are a hundred percent
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sure that this woman is in fact pregnant
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and there is a baby in there
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now given that then you can do a
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pregnancy test a blood or a urine test
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or any other marker that you choose
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and if you do the test on all hundred
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women
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and 98 of them test positive
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meaning to test negative then
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you know for sure that that test
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missed two percent of the of the women
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who you know to be positive pregnant
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so there's a false negative rate of two
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percent
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which is pretty good for a biological
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test which means that if you do the test
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and on somebody you know remotely and
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you can't figure out whether they're
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pregnant at 20 weeks
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you know that if it's positive they have
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a 98
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chance that it's an accurate test and a
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2
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chance that it's not accurate so you're
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not 100 sure
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but you're pretty close the next step
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you would do
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is take 100 women who you know for sure
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aren't pregnant or if you wanted to be
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really sure you could even do it with a
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hundred men
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in which case you're pretty darn sure
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that none of those men are pregnant
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or you could do it with post-menopausal
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women or you could do it with
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women who've had no sexual contact in
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the last year
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or any other group of a hundred women
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who you are a hundred percent sure they
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are not pregnant
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and then you do your test you do a blood
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test or urine test
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and let's say three of them test
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positive
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and now you know those are not accurate
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because you know they're not pregnant
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and so then you have a three percent
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false positive rate
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in order to have a test that has a
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84.6 percent false
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positive or accuracy rate so that 84.6
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accuracy means 15.4
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were false positive in order to do that
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by definition you would have had to do a
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hundred
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uh gold standard or people that you know
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actually have the corona virus
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so the gold standard for a pcr
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test is you take a hun a thousand people
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in this example
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because if you only took 100 you could
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only say 84
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accurate if you only did 10 people you
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would only be able to say
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10 accurate or 20 so in order to say
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84.6 you would have had to start with a
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thousand people
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and then you would have had to examine
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all thousands of them
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who have the same disease right so they
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have the same set of symptoms
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this has clearly been defined as
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covid19 sort of like chickenpox
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everybody has the same symptoms and you
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could say
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clearly this is the disease called
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chickenpox
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or you have a blood clot in your lungs
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you can see that with with an x-ray test
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you can see the clot so you know that
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all
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hundred all thousand of these people
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have covet 19. then
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you do as i've described isolation
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purification
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characterization and you find the
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coronavirus
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in each of those thousands now you know
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they have the same disease
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they have the same virus then you can
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pull out the the genetic material from
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that virus that you've now isolated
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you can find a unique piece of that
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coronavirus you can make a marker
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or segment a primer that attaches to
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that unique piece
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and then you would do that on a thousand
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people
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who don't have it and that would tell
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you the false positive rate
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and that would be how you would come up
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with that number 84.6
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now if i was speaking to a live audience
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i would say the audience anybody take a
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guess
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as to how many people right now in the
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medical literature
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have been positively identified with
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covet 19
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uh having the exact same set of symptoms
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or at least very
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similar who've had the virus isolated
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purified
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characterized found a unique segment
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so that we actually have a gold standard
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and i think
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everybody by now knows i know the exact
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answer to that question i know the exact
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number
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it's zero therefore
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because there is nothing to compare this
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pcr
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test to not even one person
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you can't say that it's 10 14
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or 84.6 or any percent
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in other words and if there's anything i
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want everybody to get take away
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from this short video there is no
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such thing as a false positive pcr
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test for coronavirus nor
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is there a such thing as a false
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negative test for coronavirus with a pcr
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test the test is not false positive
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it's not false negative it's just plain
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good old-fashioned false it means
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nothing
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because unless you have a gold standard
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you have no idea what you're testing for
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unless you've isolated the virus
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sequenced the genome
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found a unique segment which has not
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been done
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you have no idea whether you're testing
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for segments
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that come from this virus or not the
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test is meaningless
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which is why it's such a dangerous
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weapon
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because you can make the test positive
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or not
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just depending on how many cycles you
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amplify
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the sequences and that becomes a
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horrible weapon for controlling the
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numbers
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in a so-called pandemic and i hope that
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clarifies things for everybody
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and then again in the next video we're
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going to go over
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the numbers on the moduna vaccine trial
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