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These are the user uploaded subtitles that are being translated: 1 00:00:00,000 --> 00:00:03,160 In December 2019 the Chinese authorities 2 00:00:03,160 --> 00:00:06,260 notified the world that a virus was spreading through their communities. 3 00:00:06,260 --> 00:00:11,200 In the following months, it spread to other countries, with cases doubling within days. 4 00:00:11,200 --> 00:00:16,340 This virus is the Severe Acute Respiratory Syndrome-Related Coronavirus 2 5 00:00:16,340 --> 00:00:21,560 that causes the disease called Covid-19 and that everyone simply calls coronavirus. 6 00:00:21,560 --> 00:00:26,060 What actually happens when it infects a human and what should we all do? 7 00:00:27,100 --> 00:00:33,300 [Intro Music] 8 00:00:34,320 --> 00:00:41,480 A virus is really just a hull around genetic material and a few proteins, arguably not even a living thing. 9 00:00:41,480 --> 00:00:44,880 It can only make more of itself by entering a living cell. 10 00:00:45,280 --> 00:00:47,360 Corona may spread via surfaces, 11 00:00:47,360 --> 00:00:49,720 but it's still uncertain how long it can survive on them. 12 00:00:50,140 --> 00:00:56,700 Its main way of spreading seems to be droplet infection when people cough, or if you touch someone who's ill and then your face, 13 00:00:56,740 --> 00:00:58,740 say rubbing your eyes or nose. 14 00:00:59,080 --> 00:01:04,280 The virus starts its journey here, and then hitches a ride as a stowaway deeper into the body 15 00:01:04,860 --> 00:01:10,860 Its destinations are the intestines, the spleen or the lungs, where it can have the most dramatic effect. 16 00:01:10,900 --> 00:01:15,500 Even just a few corona viruses can cause quite a dramatic situation. 17 00:01:15,640 --> 00:01:19,420 The lungs are lined with billions of epithelial cells. 18 00:01:19,420 --> 00:01:25,300 These are the border cells of your body, lining your organs and mucosa waiting to be infected. 19 00:01:25,560 --> 00:01:31,420 Corona connects to a specific receptor on its victim's membranes to inject its genetic material. 20 00:01:31,680 --> 00:01:36,600 The cell, ignorant of what's happening, executes the new instructions, which are pretty simple: 21 00:01:36,660 --> 00:01:38,760 copy and reassemble. 22 00:01:38,780 --> 00:01:46,240 It fills up with more and more copies of the original virus until it reaches a critical point and receives one final order, 23 00:01:46,240 --> 00:01:47,259 self-destruct. 24 00:01:47,260 --> 00:01:53,520 The cell sort of melts away, releasing new corona particles ready to attack more cells. 25 00:01:53,520 --> 00:01:56,640 The number of infected cells grows exponentially 26 00:01:56,980 --> 00:02:03,480 After about 10 days, millions of body cells are infected, and billions of viruses swarmed the lungs. 27 00:02:03,700 --> 00:02:10,060 The virus has not caused too much damage yet, but corona is now going to release a real beast on you, 28 00:02:10,060 --> 00:02:11,620 your own immune system. 29 00:02:11,800 --> 00:02:18,620 The immune system, while there to protect you, can actually be pretty dangerous to yourself and needs tight regulation. 30 00:02:18,940 --> 00:02:25,780 And as immune cells pour into the lungs to fight the virus, Corona infects some of them and creates confusion. 31 00:02:26,480 --> 00:02:28,280 Cells have neither ears nor eyes. 32 00:02:28,280 --> 00:02:32,840 They communicate mostly via tiny information proteins called cytokines. 33 00:02:32,960 --> 00:02:36,040 Nearly every important immune reaction is controlled by them. 34 00:02:36,680 --> 00:02:41,040 Corona causes infected immune cells to overreact and yell bloody murder. 35 00:02:41,280 --> 00:02:49,740 In a sense, it puts the immune system into a fighting frenzy and sends way more soldiers than it should, wasting its resources and causing damage. 36 00:02:50,360 --> 00:02:53,100 Two kinds of cells in particular wreak havoc. 37 00:02:53,420 --> 00:02:58,580 First, neutrophils, which are great at killing stuff, including our cells. 38 00:02:58,580 --> 00:03:04,560 As they arrive in their thousands, they start pumping out enzymes that destroy as many friends as enemies. 39 00:03:04,940 --> 00:03:12,900 The other important type of cells that go into a frenzy are killer T-cells, which usually order infected cells to commit controlled suicide. 40 00:03:13,300 --> 00:03:17,780 Confused as they are, they start ordering healthy cells to kill themselves too. 41 00:03:18,230 --> 00:03:23,769 The more and more immune cells arrive, the more damage they do, and the more healthy lung tissue they kill. 42 00:03:24,260 --> 00:03:30,639 This might get so bad that it can cause permanent irreversible damage, that leads to lifelong disabilities. 43 00:03:31,100 --> 00:03:34,119 In most cases, the immune system slowly regains control. 44 00:03:34,520 --> 00:03:40,840 It kills the infected cells, intercepts the viruses trying to infect new ones and cleans up the battlefield. 45 00:03:41,080 --> 00:03:42,640 Recovery begins. 46 00:03:42,740 --> 00:03:47,820 The majority of people infected by Corona will get through it with relatively mild symptoms. 47 00:03:48,200 --> 00:03:51,580 But many cases become severe or even critical. 48 00:03:51,680 --> 00:03:55,240 We don't know the percentage because not all cases have been identified, 49 00:03:55,240 --> 00:04:00,120 but it's safe to say that there is a lot more than with the flu. In more severe cases, 50 00:04:00,120 --> 00:04:05,400 Millions of epithelial cells have died and with them, the lungs' protective lining is gone. 51 00:04:05,400 --> 00:04:13,500 That means that the alveoli - tiny air sacs via which breathing occurs - can be infected by bacteria that aren't usually a big problem. 52 00:04:13,900 --> 00:04:15,460 Patients get pneumonia. 53 00:04:15,460 --> 00:04:20,660 Respiration becomes hard or even fails, and patients need ventilators to survive. 54 00:04:20,980 --> 00:04:26,600 The immune system has fought at full capacity for weeks and made millions of antiviral weapons. 55 00:04:26,600 --> 00:04:31,120 And as thousands of bacteria rapidly multiply, it is overwhelmed. 56 00:04:31,120 --> 00:04:36,540 They enter the blood and overrun the body; if this happens, death is very likely. 57 00:04:37,180 --> 00:04:42,240 The Corona virus is often compared to the flu, but actually, it's much more dangerous. 58 00:04:42,240 --> 00:04:46,620 While the exact death rate is hard to pin down during an ongoing pandemic, 59 00:04:46,620 --> 00:04:51,760 we know for sure that it's much more contagious and spreads faster than the flu. 60 00:04:51,980 --> 00:04:56,880 There are two futures for a pandemic like Corona: fast and slow. 61 00:04:56,880 --> 00:05:02,560 Which future we will see depends on how we all react to it in the early days of the outbreak. 62 00:05:02,560 --> 00:05:06,360 A fast pandemic will be horrible and cost many lives; 63 00:05:06,360 --> 00:05:10,120 a slow pandemic will not be remembered by the history books. 64 00:05:10,120 --> 00:05:15,260 The worst case scenario for a fast pandemic begins with a very rapid rate of infection 65 00:05:15,260 --> 00:05:18,180 because there are no counter measures in place to slow it down. 66 00:05:18,520 --> 00:05:20,360 Why is this so bad? 67 00:05:20,360 --> 00:05:24,560 In a fast pandemic, many people get sick at the same time. 68 00:05:24,560 --> 00:05:28,840 If the numbers get too large, health care systems become unable to handle it. 69 00:05:28,840 --> 00:05:34,540 There aren't enough resources, like medical staff or equipment like ventilators, left to help everybody. 70 00:05:34,540 --> 00:05:36,760 People will die untreated. 71 00:05:36,760 --> 00:05:43,260 And as more health care workers get sick themselves, the capacity of health care systems falls even further. 72 00:05:43,660 --> 00:05:49,280 If this becomes the case, then horrible decisions will have to be made about who gets to live and who doesn't. 73 00:05:49,280 --> 00:05:53,700 The number of deaths rises significantly in such a scenario. 74 00:05:53,860 --> 00:06:01,420 To avoid this, the world - that means all of us - needs to do what it can to turn this into a slow pandemic. 75 00:06:01,420 --> 00:06:04,560 A pandemic is slowed down by the right responses. 76 00:06:04,560 --> 00:06:12,320 Especially in the early phase, so that everyone who gets sick can get treatment and there's no crunch point with overwhelmed hospitals. 77 00:06:12,320 --> 00:06:17,780 Since we don't have a vaccine for Corona, we have to socially engineer our behaviour, 78 00:06:17,780 --> 00:06:22,080 to act like a social vaccine. This simply means two things: 79 00:06:22,380 --> 00:06:26,460 1. Not getting infected; and 2. Not infecting others. 80 00:06:26,460 --> 00:06:30,980 Although it sounds trivial, the very best thing you can do is to wash your hands. 81 00:06:30,980 --> 00:06:33,760 The soap is actually a powerful tool. 82 00:06:33,760 --> 00:06:37,840 The corona virus is encased in what is basically a layer of fat; 83 00:06:37,840 --> 00:06:41,620 soap breaks that fat apart and leaves it unable to infect you. 84 00:06:41,620 --> 00:06:47,900 It also makes your hands slippery, and with the mechanical motions of washing, viruses are ripped away. 85 00:06:47,900 --> 00:06:54,960 To do it properly, wash your hands as if you've just cut up some jalapeños and want to put in your contact lenses next. 86 00:06:54,960 --> 00:06:59,520 The next thing is social distancing, which is not a nice experience, 87 00:06:59,520 --> 00:07:03,800 but a nice thing to do. This means: no hugging, no handshakes. 88 00:07:03,800 --> 00:07:09,520 If you can stay at home, stay at home to protect those who need to be out for society to function: 89 00:07:09,520 --> 00:07:17,420 from doctors to cashiers, or police officers;. You depend on all of them; they all depend on you to not get sick. 90 00:07:17,420 --> 00:07:24,600 On a larger level, there are quarantines, which can mean different things, from travel restrictions or actual orders to stay at home. 91 00:07:24,600 --> 00:07:28,400 Quarantines are not great to experience and certainly not popular. 92 00:07:28,400 --> 00:07:34,320 But they buy us - and specially the researchers working on medication and vaccinations - crucial time 93 00:07:34,320 --> 00:07:39,340 So if you are put under quarantine, you should understand why, and respect it. 94 00:07:39,340 --> 00:07:45,700 None of this is fun. But looking at the big picture, it is a really small price to pay. 95 00:07:45,700 --> 00:07:50,020 The question of how pandemics end, depends on how they start; 96 00:07:50,020 --> 00:07:53,560 if they start fast with a steep slope, they end badly. 97 00:07:53,560 --> 00:07:57,980 If they start slow, with a not-so-steep slope, they end okay-ish. 98 00:07:57,980 --> 00:08:02,400 And, in this day and age, it really is in all of our hands. 99 00:08:02,400 --> 00:08:04,060 Literally, and 100 00:08:04,060 --> 00:08:06,060 figuratively. 101 00:08:06,160 --> 00:08:09,880 A huge thanks to the experts who helped us on short notice with this video, 102 00:08:09,880 --> 00:08:11,900 specially Our World In Data, 103 00:08:11,900 --> 00:08:15,620 the online publication for research and data on the world's largest problems 104 00:08:15,620 --> 00:08:17,400 and how to make progress solving them. 105 00:08:17,400 --> 00:08:23,120 Check out their site. It also includes a constantly updated page on the Corona pandemic 106 00:08:23,980 --> 00:08:33,340 [Outro music]11562

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