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In December 2019 the Chinese authorities
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notified the world that a virus was spreading through their communities.
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In the following months, it spread to other countries, with cases doubling within days.
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This virus is the Severe Acute Respiratory Syndrome-Related Coronavirus 2
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that causes the disease called Covid-19 and that everyone simply calls coronavirus.
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What actually happens when it infects a human and what should we all do?
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[Intro Music]
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A virus is really just a hull around genetic material and a few proteins, arguably not even a living thing.
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It can only make more of itself by entering a living cell.
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Corona may spread via surfaces,
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but it's still uncertain how long it can survive on them.
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Its main way of spreading seems to be droplet infection when people cough, or if you touch someone who's ill and then your face,
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say rubbing your eyes or nose.
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The virus starts its journey here, and then hitches a ride as a stowaway deeper into the body
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Its destinations are the intestines, the spleen or the lungs, where it can have the most dramatic effect.
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Even just a few corona viruses can cause quite a dramatic situation.
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The lungs are lined with billions of epithelial cells.
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These are the border cells of your body, lining your organs and mucosa waiting to be infected.
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Corona connects to a specific receptor on its victim's membranes to inject its genetic material.
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The cell, ignorant of what's happening, executes the new instructions, which are pretty simple:
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copy and reassemble.
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It fills up with more and more copies of the original virus until it reaches a critical point and receives one final order,
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self-destruct.
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The cell sort of melts away, releasing new corona particles ready to attack more cells.
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The number of infected cells grows exponentially
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After about 10 days, millions of body cells are infected, and billions of viruses swarmed the lungs.
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The virus has not caused too much damage yet, but corona is now going to release a real beast on you,
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your own immune system.
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The immune system, while there to protect you, can actually be pretty dangerous to yourself and needs tight regulation.
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And as immune cells pour into the lungs to fight the virus, Corona infects some of them and creates confusion.
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Cells have neither ears nor eyes.
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They communicate mostly via tiny information proteins called cytokines.
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Nearly every important immune reaction is controlled by them.
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Corona causes infected immune cells to overreact and yell bloody murder.
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In a sense, it puts the immune system into a fighting frenzy and sends way more soldiers than it should, wasting its resources and causing damage.
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Two kinds of cells in particular wreak havoc.
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First, neutrophils, which are great at killing stuff, including our cells.
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As they arrive in their thousands, they start pumping out enzymes that destroy as many friends as enemies.
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The other important type of cells that go into a frenzy are killer T-cells, which usually order infected cells to commit controlled suicide.
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Confused as they are, they start ordering healthy cells to kill themselves too.
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The more and more immune cells arrive, the more damage they do, and the more healthy lung tissue they kill.
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This might get so bad that it can cause permanent irreversible damage, that leads to lifelong disabilities.
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In most cases, the immune system slowly regains control.
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It kills the infected cells, intercepts the viruses trying to infect new ones and cleans up the battlefield.
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Recovery begins.
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The majority of people infected by Corona will get through it with relatively mild symptoms.
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But many cases become severe or even critical.
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We don't know the percentage because not all cases have been identified,
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but it's safe to say that there is a lot more than with the flu. In more severe cases,
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Millions of epithelial cells have died and with them, the lungs' protective lining is gone.
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That means that the alveoli - tiny air sacs via which breathing occurs - can be infected by bacteria that aren't usually a big problem.
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Patients get pneumonia.
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Respiration becomes hard or even fails, and patients need ventilators to survive.
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The immune system has fought at full capacity for weeks and made millions of antiviral weapons.
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And as thousands of bacteria rapidly multiply, it is overwhelmed.
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They enter the blood and overrun the body; if this happens, death is very likely.
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The Corona virus is often compared to the flu, but actually, it's much more dangerous.
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While the exact death rate is hard to pin down during an ongoing pandemic,
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we know for sure that it's much more contagious and spreads faster than the flu.
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There are two futures for a pandemic like Corona: fast and slow.
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Which future we will see depends on how we all react to it in the early days of the outbreak.
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A fast pandemic will be horrible and cost many lives;
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a slow pandemic will not be remembered by the history books.
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The worst case scenario for a fast pandemic begins with a very rapid rate of infection
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because there are no counter measures in place to slow it down.
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Why is this so bad?
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In a fast pandemic, many people get sick at the same time.
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If the numbers get too large, health care systems become unable to handle it.
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There aren't enough resources, like medical staff or equipment like ventilators, left to help everybody.
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People will die untreated.
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And as more health care workers get sick themselves, the capacity of health care systems falls even further.
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If this becomes the case, then horrible decisions will have to be made about who gets to live and who doesn't.
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The number of deaths rises significantly in such a scenario.
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To avoid this, the world - that means all of us - needs to do what it can to turn this into a slow pandemic.
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A pandemic is slowed down by the right responses.
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Especially in the early phase, so that everyone who gets sick can get treatment and there's no crunch point with overwhelmed hospitals.
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Since we don't have a vaccine for Corona, we have to socially engineer our behaviour,
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to act like a social vaccine. This simply means two things:
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1. Not getting infected; and 2. Not infecting others.
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Although it sounds trivial, the very best thing you can do is to wash your hands.
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The soap is actually a powerful tool.
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The corona virus is encased in what is basically a layer of fat;
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soap breaks that fat apart and leaves it unable to infect you.
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It also makes your hands slippery, and with the mechanical motions of washing, viruses are ripped away.
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To do it properly, wash your hands as if you've just cut up some jalapeños and want to put in your contact lenses next.
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The next thing is social distancing, which is not a nice experience,
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but a nice thing to do. This means: no hugging, no handshakes.
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If you can stay at home, stay at home to protect those who need to be out for society to function:
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from doctors to cashiers, or police officers;. You depend on all of them; they all depend on you to not get sick.
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On a larger level, there are quarantines, which can mean different things, from travel restrictions or actual orders to stay at home.
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Quarantines are not great to experience and certainly not popular.
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But they buy us - and specially the researchers working on medication and vaccinations - crucial time
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So if you are put under quarantine, you should understand why, and respect it.
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None of this is fun. But looking at the big picture, it is a really small price to pay.
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The question of how pandemics end, depends on how they start;
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if they start fast with a steep slope, they end badly.
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If they start slow, with a not-so-steep slope, they end okay-ish.
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And, in this day and age, it really is in all of our hands.
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Literally, and
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figuratively.
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A huge thanks to the experts who helped us on short notice with this video,
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specially Our World In Data,
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the online publication for research and data on the world's largest problems
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and how to make progress solving them.
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Check out their site. It also includes a constantly updated page on the Corona pandemic
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[Outro music]11562
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