All language subtitles for Extraordinary.Measures.2010.1080p.BluRay.x264-[YTS.LT]-eng

- Hi there.
- Hi.

So glad to see you.

Kathy, could you take that?

Thank you.

It's my job to market this drug for
Bristol-Myers, and I'm telling you,

kids won't go for it unless
it tastes like bubble gum.

- Mr. Crowley, you're late.
- All right. Thank you. Bye.

"Everyone just walked by."

"'Why won't anyone buy our newspaper?
' SpongeBob wondered aloud."

"'They must be rock
haters, ' said Patrick."

- John! Give it back to me!
- She's mine now!

- Give me a minute, okay?
- Give it back to me, John!

You save our spot. Got it?

You better give
me back my Fiona!

Help, Mom!

- Help me! She's trying to kill me!
- I'm gonna get you!

- You can't escape!
- No! Mom, help me!

Just give it back to me.

- Mom! She's trying to kill me!
- Megan Kathryn Crowley.

If you kill your brother,
you cannot have your party.

Why not? He stole Fiona.

I didn't steal her, I kidnapped her.
I'm holding her for ransom.

Release the victim.

Time to get ready
for your party.

We've got to get moving
on the product launch.

I'm just waiting on legal, John.

Damn it!

I just missed my train. I'm
gonna have to call you...

I agree. How soon
do you need it?

As soon as possible. I'm
presenting to my boss next week.

John, we're loading up the
van right now. Come on!

- Okay, we ready to roll, Kate?
- My name is Jane.

- Kate was yesterday, Mom.
- I am so sorry.

The way the agency
shuffles day nurses on us,

you'd think they'd, you know, give
you a number instead of a name.

Okay, John.

John, come on, get
your butt in the car.

John.

- Are you bringing your RipStik?
- Yes.

- Do you have to?
- Yes.

A pain, that's why. Wait,
I gotta catch a cab.

Hi. Come here. Hey, hey. Hello?

- Daddy's meeting us there, right?
- Absolutely.

I am sure he has
everything under control.

Taxi!

You need a hand?

Great. I'm sorry, I'm sorry.
I'm kind of in a hurry.

Go.

Come on, come on, come on,
come on, come on, come on.

Yes!

He totally promised
he'd be here by now.

He's on his way, baby.
He's on his way.

Hi, guys.

- Get in there and give her a kiss.
- I know.

I don't wanna hear it.
I don't wanna hear it.

Go, go, go.

Happy birthday. I made it.

- Yay!
- Yay!

Make a wish, Megan.

Who wants cake?

- I do!
- I do!

Line up single file,
or no cake for you.

- All right, how many do we have?
- I'm first! Me first!

- No, I'm the big guy.
- Back to the end of the line.

So, where is Fiona
going, anyway?

Lollipop Land?

I'm eight, Daddy. I'm
not a baby anymore.

She's driving to Antarctica
to see the penguins.

Really? That's pretty far away.

Why doesn't she just go
to the Portland Zoo?

They have a lot of
penguins there, too.

- Haven't you ever heard of adventure?
- Yeah.

It's gonna take her years.

Won't she need a suitcase?

It's an adventure. You don't
need a suitcase on an adventure.

Well, I don't know about you, but
if I was going on an adventure,

I would take a suitcase.

- That's 'cause you're a businessman.
- That's right. I am.

And you're eight years old. And
happy birthday. And I love you.

Love you, too, Daddy.

- Good night. See you in the morning.
- Good night.

Nighty-night.

Sweet dreams.

Good night, Dad.

- Good night, Daddy.
- Night, buddy.

- Hello?
- Hello, Dr. Stonehill?

- Are you there? Hello?
- Yeah.

This is John Crowley. I don't know
if you've gotten any of my messages.

- Who?
- John...

Jesus.

I'm interested in speaking with you. I
understand from many researchers...

having a conversation with
you if that's convenient.

Is this a good time to talk?

Dr. Stonehill? Hello?

- Asshole.
- "Asshole?"

The night nurse just left.

What time is it?

I missed you.

This is pathetic.
I'm still dressed.

I could help you with that.

Oh my... Kate! Hi! You're early.

6:00.

- Have you met...
- I'm John Crowley.

John is my husband.

Glad to hear it.

Yeah, let's up her breathing
treatments today.

- What's going on?
- Just a cold. She's awfully congested.

- Call the doc just to be on the safe side?
- Yeah, I left word.

Sweetie? I'm gonna
go to work, okay?

Feel better.

Bye-bye.

We're already doing great
marketing the drug to physicians.

It's our direct marketing to
patients we need to beef up.

Mr. Crowley, I'm really sorry.

Aileen's on the line, she
really needs to speak to you.

Okay, thank you. I'm just gonna...
Hey.

We're at the hospital. The doc
wants Megan under observation.

- Is she all right?
- Just keep your cell with you.

- Okay. Can I do something?
- I'll call you when I know more.

I should really get back to Megan, so I'll
call you as soon as I know anything, okay?

Bye. Love you.

- Excuse me, please.
- Sir?

My daughter, Megan Crowley, was
brought in for observation.

Yeah. Actually, they're
moving her to the ICU.

- Where?
- That way.

- Aileen.
- John.

Has she told you about
the trip that Fiona's

taking with her
remote-controlled car?

Yeah, yes, she did. You're right.
That's right, sweetie.

You're gonna see all the
penguins, aren't you?

She might send some postcards
or something like that.

Lots of good stuff to
see along the way...

It's okay.

Like icebergs and
maybe a polar bear.

How about some seals?

As you know, Pompe patients suffer muscle
deterioration in every part of the body,

so this sort of respiratory
complication, well,

that's just an inevitable
fact of the disease.

Mr. Crowley, Mrs. Crowley,

Megan is not responding well.

Okay? Now, we've done everything
we can, but she's just...

There's nothing more we can do.
I'm sorry.

As you know, she was
already well past the

life expectancy, for,
you know, Pompe kids.

After all, it's not
just her lungs, okay?

Her heart, her liver, these
organs have been compromised

and would've become
fatally enlarged.

Now, I wish that we had a drug to
treat Pompe, but we simply don't.

I'm so very sorry.

Look, maybe...

Maybe you can find
some small comfort in

knowing that Megan's
suffering will be over.

Maybe you can see
this as a blessing.

- Megan?
- Help!

- Help! Help!
- Megan?

Help! Help!

Baby girl, can you hear me?

- Please, someone come help!
- 321!

- Megan Crowley, room 321, please!
- Code Blue!

- Baby girl, Mama's here, all right?
- Let's go! Page Dr. Heder.

- Asystole!
- Yeah, right through here.

Can you hear my voice?
Can you hear Mama?

- Starting compressions.
- I'll switch her out.

- Over here, please. Quickly.
- Hang in there, Megan.

- Hang in there, baby, okay?
- I need to bag her.

- Aileen?
- Some room right there.

Let us in, all right?

- Please, Mrs. Crowley, let...
- Stop it!

Let us help her!

- Please... Megan!
- Aileen.

- Epinephrine, 0.1 mils per kig.
- Got it.

Still no pulse. No reading.

Forget the weight, come
on, get it in there!

Aileen, Aileen.

- 0.1 epi.
- It's all right.

- Come on, Megs. Come on. Come on.
- IV push.

- Okay, just give the epi a couple seconds.
- Still non-responsive.

- All right, charge the defib.
- Charging.

Your daughter is some fighter.

- She's gonna be okay.
- Oh, my God.

Now, look, she's still a
very sick girl, obviously,

but her vital signs have improved
and I'm cautiously optimistic.

So, I guess you could say we
dodged that blessing, huh?

- Mrs. Crowley, these came for Megan.
- Thanks so much. Thank you.

Hey, John?

Any time you're ready, man.

You gonna tell us about
the product launch?

John, you okay?

I have to go.

John.

- Where you going?
- Nebraska.

Excuse me, please. There's a
gentleman here to see you.

Best make yourself
comfortable, hon.

Oh, dear.

Sir, sir. That's Dr. Stonehill.
He just left, I'm sorry.

- Thank you.
- Yeah.

Dr. Stonehill!

Hey, Dr. Stonehill!

Dr. Stonehill?

- Yeah?
- I'm John Crowley.

- Okay.
- Didn't you get any of my messages?

What messages?

I left you three or four
messages in the last month,

and you even hung up on
me the night before last.

What the hell are you talking about?
I never hung up on you.

Dr. Stonehill, two of
my kids have Pompe.

Oh, Jesus.

Well, I'm sorry.

A terrible disease,

but, hell, you shouldn't have come
all this way without talking to me.

I do research, son. I
don't see patients.

Well, it's your research
that I'm interested in.

I've read all the journal
articles on Pompe disease,

and all the researchers out there say
that your work holds the most promise.

Get to the point, son.
What do you want from me?

We almost lost my
daughter last week.

I need to hear about
your research.

Your kids have a
genetic disease.

They're missing an enzyme

which metabolizes a certain
kind of sugar, glycogen.

It's defective in
Pompe patients.

So, this sugar builds
up in the muscle cells,

especially in the heart, the
skeletal muscles, the diaphragm,

which is why they have
a hard time breathing.

- Yeah, I know. I know a lot about that.
- Everybody's making an enzyme,

but you can infuse kids all
day long with their enzyme,

and it's not gonna do any good 'cause
it's not gonna get into their cells.

Understand what I'm saying?

Yeah, so that means that
if you put the sugar...

- Don't interrupt.
- Sorry.

I'm making a different
version of this enzyme.

My enzyme has a biological
marker, mannose 6-phosphate.

I'm the only one that's cloned
the gene for phosphotransferase.

I'm the only one who's cloned
the gene for uncovering enzyme,

so I can get more mannose 6-phosphate
onto the lysosomal protein,

and I can deliver a more
effective amount of enzyme

into the cells.

That's why people
are citing my work.

That's why you read my
name in the literature.

I can get more enzyme
into the cells.

What's the matter, Sal? Not
up on your glycobiology?

I thought Doc was
just your nickname.

No, that man's a genius. He's on the
verge of a scientific breakthrough.

Wow. Who knew?

I'm not on the verge of anything, kid.
This is a theory, not a therapy.

I'm just an academic.

You got any idea how
shitty my funding is?

No.

University of Nebraska
pays their football coach.

Nobody's paying
attention to this work.

Half my grants don't
get approved.

I don't have the money to make my
theory into a useable medicine.

How old are your kids?

Six and eight.

Look, do yourself a favor. Go home
and spend time with your kids.

Enjoy 'em while
they're still here.

- How much?
- How much what?

How much money would it
take to prove your theory,

to create your version
of the medicine?

I'd need half a million bucks
just to fund the lab work.

- That's why you need me.
- I need you? Why?

Because I'm the founder of the
Pompe Foundation for Children.

I've been working on this
disease for 10 years.

I have never heard of you guys.

That's because we're relatively new.
We're just in the gearing-up phase.

- How soon do you need a grant?
- Now would be good.

Well, not all the money's in
place, but it will be, and soon.

This is a very exciting time.

- Thanks.
- Thank you, sir. Have a good day.

Hey.

You okay?

- Did you get my messages?
- Your messages?

You suddenly walk
out of the meeting

and fly to Nebraska without
talking to me about it,

and you think messages
make it okay?

- I'm sorry.
- My God, John.

I wanna find a miracle
as much as you do, okay?

But how could you put
yourjob in jeopardy?

- Aileen.
- How exactly

do we pay $40,000 a month in
healthcare if you lose your insurance?

Honey, come on. Look, I'm
not gonna lose my job.

Oh, really?

Pete called here twice last
night to ask if you were okay.

You know, mentally.

I'll just... I'll call, and
I'll smooth that one over.

Yeah, no shit.

I'm sorry.

Something in me just
kind of snapped.

That night at the hospital, when we
thought that we were losing her,

I prayed that if
it was her time,

she'd go quickly, without
so much suffering.

But morning came, and
she pulled through.

Her eyes,

so determined, so defiant.

The fight in her.

Was he worth it?
This Stonehill guy?

He's really eccentric, but his science
is way ahead of everybody else's.

He's definitely the one
to put our money on.

Lf we had any.

I promised him that
we'd raise some,

because he's got this
conference up here next month,

and I said I'd have a
check ready for him.

- How much?
- Five hundred.

- That's all?
- Thousand.

Is it $500 or $1,000?

$500,000.

By next month.

- Sweetheart, are you totally insane?
- Apparently.

We're holding our first fundraiser
on the 23rd at the school,

and we would love if you
and Frank could join us.

- Ready for your spelling test?
- I'm gonna nail it.

Okay. Good luck.

My name's John Crowley.
I'm calling from Oregon,

and I got your name from the
Atlanta-area Pompe parents' group.

Yeah.

And I was so sorry not to
see you at the reunion

because you were one of my most
favorite people in high school.

Anyway, John and I are
starting this foundation.

- Hey, Dad? Dad.
- No, you know what I mean.

Just make it right.

- Dad?
- Can't you see I'm on the phone?

- Okay, well, tell me what he told you.
- Dad!

No, I'm gonna have to call you back.
I can't talk. All right, bye.

- Yeah, what is it?
- I sold my RipStik.

Okay.

Is it enough to give to Megan
and Patrick's foundation?

Yeah, it's more than enough.

- Are you John?
- Yes.

- Marcus Temple. We spoke on the phone.
- Right. Absolutely. Good to see you.

- All the way in from Atlanta.
- Yes.

Well, this is for your foundation, from
my relatives, friends and church group.

My goodness.

Thank you very much.

Thanks.

- Hi, Dr. Stonehill. I'm Megan.
- Hi, Megan. I'm Dr. Stonehill.

Yeah, that's why I said, "Hi, Dr.
Stonehill."

- Are you coming in or not?
- Yeah, thanks.

Where's Mom and Dad?

They'll be down in a minute.

Patrick's vent alarm is going
off, so they need to fix it.

His alarm goes off
even more than mine.

So, what's your deal?
You married?

Do you have a wife?

Ex-wives. Two of 'em.

- Yeah? How come?
- 'Cause I'm so easy to get along with.

- Any other questions?
- No. Your turn to ask one.

You're probably wondering
what grade I'm in.

- What grade are you in?
- I'm in third.

My hobbies are video games and penguins.
How about you?

- I already graduated.
- No, I mean hobbies.

Mostly I just work.

Little bass fishing every
once in a while, but...

What's your favorite subject?

I'm good at reading, but I like P.E.
Best, especially the sprint races.

Sprint races?

- Wanna see?
- Sure.

Come on.

- Is he here yet?
- I don't know.

I'm gonna win!

Come on, slowpoke.

Yeah, I won!

I won.

Oh, yeah.

Told you I'm gonna beat you.

Hi.

Dr. Stonehill has two ex-wives.

- I see that Megan's introduced herself.
- Yeah.

- How are you, Dr. Stonehill?
- I'm okay, thank you.

- This is Aileen, my wife.
- So nice to meet you.

- And John Jr.
- Hello.

- Here's Patrick.
- Hi.

- Hey, Patrick.
- I think we should probably go inside.

Yeah, come on inside.

Megan, we'll see you inside.
Come on.

- Night, Patrick.
- Good night.

Night, SpongeBob.

You gotta say good night to Dr.
Stonehill.

Kiss SpongeBob.

- Good night.
- Good night, son.

Good night, Patrick.

I'm not gonna say it again.
It is bedtime now.

It's for him.

- Me?
- For good luck. For bass fishing.

Thank you.

You like it?

Well, sure. A happy-go-lucky little
fellow, lots of personality, huh?

- He's a plastic toy.
- I know.

Here's the
father-daughter dance.

You haven't lived until you've seen
Megan do the Wheelchair Watusi.

Here you go.

Go ahead and eat the
cobbler while it's hot.

Smells great, honey.

This was hilarious.

Bob, we went to this dude ranch.
All right if I call you Bob?

You got a check for a half-million
dollars, hell, you can call me Peggy Sue.

I'll just...

Well, Bob.

This is the first installment against
the promised half a million.

Tell you the truth, that's
more than I expected.

Dr. Stonehill, we
promise that...

- Yeah, I know.
- Lf... In enough time, then...

I know. I know.

You can learn a lot about a person
on the Internet these days.

Learn about a working-class
kid from New Jersey,

worked his way through
Harvard Business School,

clawing his way up the
ladder at Bristol-Myers.

But what Google can't tell you

is that this scared, desperate,
bullshitting son of a bitch...

- Wait just a minute...
- Don't interrupt.

Will do and say whatever
it takes to get results.

Which is why you and me are going
into business together, Jersey.

Excuse me?

I'm tired of begging breadcrumbs
from the university

and giving them the
patents to my ideas.

They don't value my work.
You do,

which is why I'm setting
up my own shop.

Figure any dude in
a business suit

can help me raise venture
capital and run the company,

but who's gonna be half as motivated as a
dad who's trying to save his own kids?

So, this is...

So this is the shittiest
offer you're ever gonna get.

I can promise you less money, longer
hours, lousy working conditions,

plus, if we raise the money, you're
gonna have to relocate to Nebraska.

And with the right
business plan,

I can also promise you a working
enzyme for Pompe disease.

I can't cure your kids, you know that.
They're always gonna be in wheelchairs,

but I think I can
save their lives.

Outstanding cobbler.

Okay, okay. So, we agree
we can't uproot the kids.

What if Stonehill fails?

Or what if he succeeds too
late to help Megs and Patrick?

- Then what?
- I know.

If we're gonna lose them young, you want
to spend every minute you can with them.

John, that day that
you flew to Nebraska,

when you suddenly just
ditched work and...

My God, I thought you'd lost it.
You scared me.

But once we rolled
our sleeves up,

and we started fundraising and
meeting other Pompe families,

it made me feel like...

I mean, do we just
accept our fate

and do what we're told by all
the well-meaning doctors

and wait for the worst to
happen, or do we fight it?

I think you're making a mistake.
I really do.

Even if you were credible as
a CEO, which you are not,

the odds against you are crushing. Nine
out of 10 biotechs crash and burn.

So where does that leave your
kids when their dad is flat broke

with no job and no
health insurance?

Now, if you stay at Bristol,

the guys upstairs are ready to put you in
the VP slot at the end of the third quarter

with a 40% salary bump.

John.

Your family's gonna need
that money, aren't they?

Pete, you're right.
This is crazy.

I'm chasing the wind.

But I can't just

sit around and wait
for my kids to die.

I can't do it.

You have arrived at
your destination.

Come on in. It's open.

- Hey, there, Bob.
- Hey, John.

How are you?

- You have trouble finding me?
- No problem.

- Sit down.
- Thanks.

Ex-wife. She loved cats.

Well, say, what do we...

What are we gonna do? How
about we work up a strategy

for the meeting at
Renzler next week?

We don't need to show
those guys anything.

The meeting's a formality.

George Renzler and I have known
each other since med school.

He's been telling me for years
that he'd give me the seed money

if I ever decide to make the big
move and set up my own shop.

Well, that's good. That's good,
but, still, all the same, you know,

if we're gonna go in to pitch 'em,
we should have something tangible.

Those guys understand me.
They're real scientists.

They're not like a lot of
these big biotech moneymen.

Okay. All right, tell you what, how
about if we just talk it through,

and then that way we can just
sketch up something rough on paper?

You give it to me, I'll
make up a business plan.

We need to rough out a real strategy.
These guys are venture capitalists.

That rough enough for you?

Bob? Look, Renzler's crucial to us. Without
them onboard, we got zero credibility

- with any of our investors.
- That's why you're here, Jersey!

Whip up some business
bullshit by tomorrow.

- I'm going fishing.
- This is... This is gibberish!

Then you better get busy.

See you.

As you know, the market potential
for an orphan drug is enormous.

If you were still in business
school, I'd give you an A

for all these lovely
charts and graphs and...

But school is out.

Most of us here are scientists.
We need to see the science.

Bob, make us believe.

Love to, George.

The phosphotransferase and the
second uncovering enzyme...

At this point, the challenge
is to scale up this process

to produce kilogram
quantities of HPGAA.

And the question is whether
or not it's cost-effective

to contract this work out or to build
our own manufacturing facility.

Either way, we're gonna eventually need an
investment on the order of $10 million.

It's a lot of information
in a short period of time.

Does anybody have any questions?

- This is astonishing.
- Well, thank you, George.

This man is light years
ahead of the field.

Okay.

Well, why don't you have your
money guys get together with John

- and work out the business...
- Sounds great.

Of course, we'll need you to explain
some of the mundane stuff, Bob,

the nuts and bolts.

- Nuts and bolts? What...
- Yeah.

You're a brilliant theoretician,

but you've never actually brought a
new drug to market before, right?

No, I've never brought a drug to market.
I haven't.

I mean, for example, how are you
getting the phosphotransferase?

I'm purifying it out of a
lactating bovine udder.

I see. And where are you
getting the udders?

From the stockyards.

- Pretty straightforward stuff.
- Not really.

- You can't inject cow protein into people.
- I know that.

The bovine version of the enzyme is
for lab work, for proof of concept.

I'll make a copy of the human
enzyme for actual drug trials.

- What about uncovering enzyme?
- What about it?

How exactly do you
plan on making

- an exact replica?
- I'm making it in T-293,

out of human kidney cells.

- Oh, my goodness. No.
- "Oh, my goodness. No?"

No. The FDA will
never allow that.

- Hey, Bob, just...
- Wait a second.

For Christ's sake, we will change the
cell line before clinical trials.

You've gotta have that process locked
down long, long before you think about...

Bob, why don't we just
take a coffee break...

Why are you talking to me this way?
I don't want any goddamn coffee.

Bob, can you just tell us
how you're planning to make

the three enzymes under
FDA-approved GMP in...

I'm not here to cross every "t"
and dot every "i", George.

And I'm not here to be poked and
prodded like a first-year med student.

- This is ridiculous.
- Bob.

This is bullshit.

Bob.

Bob, if you can't answer a question, you
say you're working out the details.

You don't storm out on these guys like
some sort of spoiled child, okay?

- Now, we're gonna go back in there.
- No, I'm not going back in there.

We're going back in there. This is
business, Bob. It's not personal.

That was personal.

Stonehill goes and completely
sabotages the meeting.

Thank you.

I mean, he completely blew my
plan, right out of the gate.

Okay, I get that he's a loose cannon, but
do you still believe in his science?

Honey, if I don't raise
$10 million in capital,

his science doesn't matter.
At all.

What's going on with his arm?

Hey, buddy, you okay?

- You all right?
- I can't throw them anymore.

- When did this happen?
- I don't know.

- You should help him, Daddy.
- That's a good idea.

Okay, here we go. You ready?

- One, two...
- Into the water.

That was a good shot. We
can do better than that.

Try again. Let's make,
like, a little pellet.

Here, ducky, ducky.

Let's do it again.

Ready? One, two, three.

Give me another piece, John.

I can just throw them.

And you do all the laughing,
and I'll do all the throwing.

That's good, the ducky shared.

- Did you see that?
- Yeah.

John?

- We're out of time.
- I know.

He doesn't have the strength to
throw a piece of bread to a duck.

- It scares the hell out of me.
- Me, too.

John, what are you doing?

I'm offering Renzler a
deal he can't turn down.

Excuse me. Morning. Dr. Renzler?

Dr. Renzler?

Sir, good morning.

- John Crowley.
- Crowley?

- Yes, sir.
- What are you doing here?

- Good morning.
- Good morning.

I understand from your secretary that
you're going to be leaving for France

- for a month.
- That's right.

I have a proposal for
you, and I was hopeful

- that you could take a look at it.
- We're running late for a flight.

I appreciate that. It'll only take a
second, just to have a quick read.

- Fine. I'll read it in the car.
- It might interest you.

Good, thank you.

- Does Stonehill know about this?
- Of course.

And he's okay with these terms?

All I need is your signature.

Hello?

Bob.

Bob!

Over here.

Bob.

Bob!

Hi. Bob.

What'd you do to yourself?

- I got the investment from Renzler.
- You what?

Listen, I want you to

think about something
before you read that.

What the hell is this?

Under the circumstances, this is the
best deal that we could ever get.

This isn't a deal. This is the
terms of our surrender, for...

Renzler comes in for a
couple of million now,

and you give him the option ofjumping
in as a full partner later?

Well, after sabotaging our meeting,
I had to do something dramatic.

And you promise him we'll be
in clinical trials in a year?

We can do this, Bob. All right?

We work harder, we push ourselves,
we work around the clock.

I already work around the clock!

Why don't you just give 'em
my balls in a jelly jar?

There's no other way I could get
them to come back to the table.

Who needs the bastards anyway!

Without Renzler, there's no reason for us
to even think about other venture groups.

Fine! Then I won't think
about other venture groups!

Great!

Spend the rest of your life dreaming
up great ideas that don't get funded.

Draw brilliant diagrams on the
wall that cure diseases in theory,

but never help a single
human being in reality.

What'd you do? Let me see it.

- It's just barely...
- Let me see.

Put pressure on it.

Got your blood all
over this thing.

Want me to add a drop of
mine, make it official?

Or would a signature suffice?

Bob?

I'm not paying a dollar more
than 22,000 a unit, okay?

I'm not doing it.

Hi, Bob.

These guys make me feel old.

Scientists get all sensible and
careful when they get old.

Young ones like risk,

not afraid of new ideas,

and you can pay 'em less.

We all believe in Bob Stonehill's bold
vision, otherwise you wouldn't be here.

But to reach clinical
trials inside of a year,

I'm gonna have to ask you to
commit to a brutal schedule.

Ladies and gentlemen, reset
your watches to Priozyme Time.

- How long?
- Three, four hours.

Well, if you can get it any
quicker, that'd be good.

I'll try.

Come on.

- Vinh, check the breakers.
- Got it.

- No, the whole building's out.
- Well, get the backup generator going.

- We...
- Wait, wait, wait.

You never bothered to
buy a backup generator?

We're in the middle
of tornado country,

- for Christ's sake!
- Yeah, so I'm a meteorologist?

If I don't have my refrigeration back in
45 minutes, I lose the whole cell line.

Four months of work pissed away!

It was never in the budget. We
never had the money for it.

I'm sorry, sir. Your
card, it's been denied.

What?

It got maxed out. I bought the
roller bottle unit for the lab.

Shit, I...

Just pay me back by the end of the
month, or I lose my apartment.

Hi, here you go. Thanks.

Yes!

Sir.

Thank you.

Fiona's in Mexico this week.
They've got pyramids there.

She's still got lots of things to
see before she gets to Antarctica.

Yeah.

She's gonna chop up all
the penguins with an ax.

And feed their bloody
remains to the walruses.

I see.

What?

Every time you come home for the
weekend, you don't even listen to me.

Megs.

You know what, you're right.
I'm sorry.

It's just that I've been so busy

trying to make the special
medicine for you and Patrick.

- I want it pink.
- You want what?

The special medicine.
I want it to be pink.

Okay. I guess I can ask Dr.
Stonehill.

Tell him dark pink, like this. Not
light pink. That's for babies.

Okay.

Here you go.

Dr. Renzler, be reasonable. The
company is only six months old,

and we are making great progress
towards in vivo testing.

I don't know. The way the
company is burning money...

Well, we've got to get a
leg up on the competition.

You know that Zymagen has far
more spending power than we do.

So, what you're saying, I should
have invested in Zymagen.

No, what I'm saying is, is that
we've got to beat 'em to the punch.

Either that, or scare
them into buying us out.

Well, you're scaring us investors a hell
of a lot more than you're scaring Zymagen.

You sell the company to Zymagen,

you're in clinical trials by
the end of the fiscal year,

or we pull the plug and cut our losses.
Goodbye.

Hello?

This construct's
looking pretty good,

but we gotta get better cleavage between
the alpha and the beta subunits.

Well, what if we add a furin site
like the one in uncovering enzyme?

Why would you wanna do that?
Doesn't it have its own...

We need to talk.

- I'm busy.
- You're always busy.

You always wanna talk.

Yeah, we could add furin and try
and cleave it before purification.

What are you doing?

- Giving you a preview...
- Guys, would you excuse us for a minute?

Of what's going to happen if we are not
in clinical trials in four months.

Our investors will
turn out the lights.

Science takes time, Jersey.
Don't they understand?

Yeah, they do. They can read
the Wall Street Journal.

They see that Zymagen is testing
three different Pompe drugs.

They're testing three 'cause they don't
know what the hell they're doing.

I'm testing one 'cause
it's the right one!

I know. I believe you, Bob.

Why else do you think I put
up with all your shit?

Look.

I want you to go toe-to-toe
with Zymagen's scientists.

- Prove to them that your enzyme is best.
- I can do that.

That's the reason I've entered
into conversations with them

to buy our company.

You're telling me?
You're not asking me?

Come on, Bob. I am just
being fiscally responsible.

Nobody is gonna tell
me how to run my lab!

If I can engineer a deal, and
that is a really big "if,"

you're going to have to forgive me for
all the money I'm gonna make you.

I don't care about money.

I'm a scientist. I care about
more important things than that.

Don't you tell me about more
important things to care about.

Do the math.

Either we sell the company and
get a huge cash infusion,

or the investors
will shut us down.

Where you going?

I'm gonna go take a crap, if that
meets with your fiscal approval.

What, they can't drive from the
airport like ordinary people?

Bob, we need to
make this happen.

They're gonna ask us
some tough questions.

Don't take 'em personally, all right?
All right?

These lab results confirm what
I've been preaching for years,

that phosphorylation is
key to enzyme absorption.

My theory works for Pompe,

and eventually it'll work for
enzyme replacement therapies

for other lysosomal
storage disorders.

- Is it too complicated?
- Too complicated?

The number of variables built into
your approach are mind-boggling.

I mean, Jesus, if you get even one
piece wrong in the synthesis,

just one carbohydrate ends
up in the wrong position...

Well, it's gotta be done right,
like anything worth doing.

You've never actually
gotten a drug approved.

Isn't it naive to think you can solve
these kinds of manufacturing challenges?

Bob? Bob?

You're right, I'm a theory guy.

My head is in the clouds.

Which is why we need you.

Unless, of course,
your reputation

for solving protein-manufacturing
problems is undeserved.

Nice one.

- I still need to hear about profitability.
- Certainly, certainly.

As you know, this is not a one-time
treatment. It's a lifelong therapy.

And these patients,

they are going to generate revenue over
the span of their lifetime that is...

But even if you make a usable enzyme,
clearly it won't work for all patients.

So, what survival rate do we
need to achieve a robust profit?

What rate of patient death can
be defined as acceptable loss?

Acceptable loss?

I understand the question.

Because the profit margins on this orphan
drug are so incredibly high, the...

Even with a mortality rate of, say,
25% over five years still indicates

that there is a highly lucrative
revenue source to be realized.

Gentlemen, we have a deal.

Dr. Robert Stonehill
to see Barry Renee.

I have a Dr. Robert
Stonehill to see Dr. Renee.

- Sir, you need to be cleared.
- I'm just gonna use the restroom.

- You need to be cleared to do that, sir.
- Just need to...

- You need a security badge.
- Jesus.

Well, can I have a security
badge so I can go take a pee?

Yes, sir. He will
give that to you.

- Hey, Bob.
- Hey, John.

You getting comfortable?

Define "comfortable."

You haven't cashed it yet?

I haven't earned it yet.

I'll cash it when we
have a usable enzyme.

Well, it sure is beautiful.

It sure is big.

The kids love it.

Seize the day.

Okay.

I'm stuck on this call.

Just wanted to let you know how thrilled
we are to have you onboard, John.

It's an honor.

- You remember Dr. Kent Webber.
- Of course.

- It's good to see you again.
- Good to see you, too.

I'll let the two of
you get into it.

- I'm expecting great things.
- Yes, sir.

I've got some pretty good ideas about
how to help the flow of information

between the four
core enzyme groups.

Whoa, John, slow down. That's
not our established procedure.

Pardon me?

The four core teams are essentially
in competition with each other.

It's an entrepreneurial model.
It works.

I'm all for competition, but
surely there must be some channel

for allowing sharing scientific insights
that can help develop all four enzymes.

John, in the interest of saving
us time, let me be blunt.

Most of the scientists
here don't like the idea

of having a non-scientist as
senior VP of the Pompe program.

Especially one whose objectivity

might be clouded by having
children with the disease.

I'm telling you this in
your own best interests.

Erich wanted to buy
Stonehill's ideas,

and he couldn't do that without also
swallowing you as part of the pill.

My advice to you, John, is
to keep your head down.

- Thank you for that wisdom.
- You're very welcome.

All of your lab notebooks must be
submitted to the review committee!

This is my lab now! Get out!

I'm just trying to
explain the protocol!

- You're wasting my time.
- Dr. Stonehill...

Fine.

What do you want?

I just dropped by to say that I think
that we might be missing an opportunity

to open a dialogue with the
other three core teams.

The other core teams?
Core teams.

Core bullshit.

I'll come back another time.

The decline in muscle strength
is very troubling, of course,

but it's really, in both kids,

the organ enlargement, the
liver, and especially the heart,

that's the real threat
to their lives.

We'll continue to monitor the
rate of cardiac enlargement.

- We'll keep tabs on their other organs...
- How long?

- I don't like to predict.
- Please.

Dr. Waldman, we won't hold you to it.
We just need to know something.

John.

How much more time do we have?
How long?

Well,

if there's another respiratory
crisis, all bets are off,

but otherwise,

Megan, maybe a year.

Patrick, less.

Thank you.

Marcus.

- Get the phone.
- What?

- The phone.
- Who is it?

- Hello?
- Hi. Is that Marcus?

- Yeah, yeah. What time is it?
- Yeah, I'm sorry. It's late.

- It's John Crowley.
- John, what you doin'?

You okay?

Hey, look, I gotta
ask you a favor.

- Morning, Gavin.
- Morning, sir.

Is my 11:00 with
Henessey confirmed?

Yes, and there's the breakfast
meeting down in the cafeteria.

Breakfast meeting?

There was an e-mail that
came in over the weekend.

Everyone on the Pompe
project was invited.

- Who called the meeting?
- Mr. Crowley, I believe, sir.

What?

Something that people ask me all the
time is how we have two kids with Pompe.

By the time we realized
that Megan had Pompe,

I was already pregnant
with Patrick.

I mean, I can't tell you
how many doctors we saw,

and the message was
always the same,

that there is no
drug to treat Pompe.

But thanks to you, all of you,
that message is changing.

What you've given us, and a lot
of other families, is hope.

So, thank you.

Good job, Aileen.

Now I'd like to welcome
the Temple family,

who've come all the way from
Georgia to be with us here today.

Thanks, John.

Hi.

I'm Marcus.

This is my wife, Wendy.

Our daughter Lauren,
our oldest daughter,

Lauren wanted to come today
and say hi to all you guys.

She's a little weak,

but she wanted us to show
you guys her picture

and to send you her love.

And this is our daughter, Megan.

The most beautiful
girls are named Megan.

Megan is four months old,
and you can't see it yet,

but she has Pompe, too.

I...

I can't tell you
what it means to us

to have all of you working on
a medicine for our children.

Thank you.

Thanks so much.

- Hey, Kent.
- John.

So what did you
think of the event?

In medical research, John,
objectivity is key.

If researchers get
all emotional,

all desperate to help suffering
patients, they'll cut corners.

It's counterproductive.

Counterproductive is having
four core teams of scientists

working together on the same disease,
but not talking to each other.

Most of these guys have never even
seen a kid with Pompe before.

I don't see how that's relevant.

Did you see Erich? That's the
kind of motivation that we need.

I'm gonna ask him to get the core team to
stop competing, start working together.

Create a leadership team.

Well, if you hope to sell
this leadership team idea,

there's only one way
to convince Erich.

And what's that?

Keep your guy,
Stonehill, off the team.

In his short tenure here, he's managed to
alienate a remarkable number of colleagues.

You can't put him on a team that's
supposed to build cooperation.

So, decide how badly you
want your leadership team,

then do what you have to do.

That's it.

Dr. Stonehill, please.

Turn it down. Yes.

Yes, the music.

I said down!

This guy's impossible.

I like that song.

Hey.

What's up, John?

- Everything all right at home?
- Yeah.

Have you heard that Erich Loring

has agreed to put together
a leadership team?

Yeah, I heard some rumor about it.
What bullshit.

Now I'm gonna have to spend a couple of
hours a week jawin' with Zymagen guys?

No.

No. No, you won't, 'cause I'm
not putting you on the team.

What'd you say?

I really wanted to.

You're not putting me on the team?
Is that what you said?

What are you, some
varsity track coach?

They didn't buy our company 'cause they
like your lvy League charm, Jersey.

It's me they wanted.

You can't bench me. It's
against the laws of nature.

You're still gonna be able to
prove that your theory is right.

Yeah, but other scientists are gonna
evaluate my results, right? Not me.

Everyone here reveres
your science.

This is about
interpersonal issues.

- Who put you up to this?
- The decision was mine.

It's for the overall
good of the program.

"For the overall good
of the program."

Wow, John, you really got the
corporate lingo down good.

What's next, "Acceptable loss?"

No.

Does anybody really
know how to do this?

Except for us.

- But wait, who's going?
- It's John's turn still.

Nice one.

Okay. I'll get it.

Nice one, Megs.

Hello? Marcus, hi.

Oh, my God.

Man. I almost got 'em down.

You guys sit tight, okay?
Here, John, grab him.

If there is anything we can do,
anything at all, will you call?

Okay. We love you guys so much.

Okay, bye-bye.

Aileen.

That was Marcus Temple.

Lauren...

She...

He said she went in her
sleep, that it was peaceful.

How old is she?

How old was Lauren?

Lauren was nine years old.

Come here.

That way, we can be certain that
we're developing the correct one.

Forget certainty, and let's try and figure
out which enzyme has the better odds.

If we develop only one enzyme,

what would happen if we
guessed the wrong one?

Mr. Crowley, I've asked Kent
to set up a testing protocol

to help us guess right.

We'll do an exhaustive
range of tests.

I'm calling it "The Mother
ofAll Experiments."

The four enzymes will be color-coded,
yellow, blue, green and magenta,

and known only by
those color codes

so no researcher will know
which one he's testing.

Only after we pick a winner, the
secret identity will be revealed.

Come on, Megan!

But I want to!

- Just roll your wrist.
- I can't.

It's okay. It's all right.
Let's try another one.

Okay. Let's try again. Ready?

Ready?

One, two, three, go!

- Big winner!
- Yay!

Here you go, look at that.
You got a penguin.

Hey, Bob. Bob.

How you doin'?

I brought you some ribs.

Not as good as the ones
from The Corner Saloon,

but if you're hungry...

What do you want?

The results.

"Mother ofAll Experiments."

Well,

which enzyme did they choose?

The leadership team spent the
whole afternoon arguing.

Two enzymes, coded yellow and
green, are ahead of the others,

but it's too close to call.

Tomorrow, we spend the day hashing it
out to decide which one to choose.

Bob. I'm asking
you to read this.

I value your opinion more than
anyone else in the world.

Well, maybe you should have valued
my opinion a little sooner,

instead of playing hatchet
man for the bean counters.

Get the hell out of my lab.

It's in your interest to
know about this, Bob.

Get out.

- Wouldn't it benefit you...
- Get out.

The green enzyme's the best. Show 'em
my analysis, they'll understand.

Hey, wait up, Bob.

Is the green enzyme yours?

I recognize patterns in the results.
I'd know my baby a mile away.

- So the green one is yours?
- No.

No, it's not.

My theory is still the best, but
it's not ready for manufacture.

Theirs is crude and
uninspired, but it's ready.

Bob, I don't even know the
words to say thank you.

Don't bother.

I didn't do it for you.

Yes, it is!

Oh, my gosh. Do you see
the kite up there?

Yeah.

That's so cool!

Annie, careful!

- Building a bastion.
- Right there. Yeah.

- Three!
- Okay!

Dad, like... Ready?

- Dad, you promised no more phone calls.
- I know. I know I did, but...

What's in there?

We can take turns burying
the phone when I get back.

Okay! I'll start digging a hole.

- You hold that for a sec.
- John Crowley.

John, it's Kent Weber.

Kent, hey. Did you get my suggested
protocol for the clinical trials?

Yeah.

You made some pretty
optimistic assumptions

about where our enzyme
supply will be.

I see.

Well, what do you think
that a more realistic...

John, I'll give it to you straight. The
clinical trial will be for infants only.

Infants need so
much less enzyme,

and, as you know, our initial
supply will be so limited.

And the drug has much higher
odds of being effective

with infants than
with older children.

We have to consult Erich on this.
We have to consult Erich.

I already did. He confirmed the decision.
Infants only.

I understand your
personal reasons for...

These decisions have to be
made objectively, rationally.

I'm sorry. I...

I really am.

Hold it, pal.

- Mr. Crowley, what are you doin' in here?
- I was just...

- You're not authorized.
- No... I can explain everything.

What's the matter, Chuck?
Is there a problem?

Yeah, there's a problem. I got Mr.
Crowley in here without clearance.

That's my fault, now.

I got busy in the lab, I sent Jersey boy
here to get me a couple jugs of enzyme.

Sorry.

Thanks, Chuck.

Thanks for saving my ass.

It's really big of you,

especially after what
went down between us.

You mean your ruthless,
cold-hearted betrayal?

Yeah, well, when I thought about
it from your point of view...

Shit, if it was my kids dying, I wouldn't
have hesitated to crush you like a bug.

Do you remember
when we first met,

and you told me that I
should stop chasing miracles

and should go home
and enjoy my kids,

while they're still here?

- Yeah.
- I made the wrong choice.

- Jersey, you know what a sibling study is?
- No.

It's a drug trial with just two patients
with the same genetic inheritance.

Siblings, with the same disease.

Megs and Patrick.

Well, would Zymagen go
for something like this?

There's real research
value in it.

And with just two patients,
it wouldn't take much enzyme.

But Webber would have
to sign off on it.

Well, let's not tell him till
we've got our ducks in a row.

I could draw up a protocol and see if I can
find a hospital willing to administer it.

- Bob.
- Well, don't get your hopes up, kid.

It's a Hail Mary.

Ducks in a row.

"Stonehill, careful review,
protocol, Sibling Trial, 146,"

"are pleased to inform you
Megan Crowley and Patrick"

"have been accepted
into the trial!"

- I just got it.
- Quack, quack, quack.

Have you talked to him yet?

No. I did the science.
You make the sale.

Thank you.

- Good luck.
- Right.

- Does he have about five?
- He does, yeah.

- Thanks.
- No problem, Mr. Crowley.

Hey, Kent? Knock-knock.

Got a minute?

Kent?

- Do you have any idea what you've done?
- Excuse me?

We got a call this morning
from Portland Rose Hospital,

about sending them
enzyme for your kids?

Right. Yeah, I know. That's what
I'm here to talk to you about.

You and Stonehill set this up
behind my back. Now you come to me.

It's all tentative.

You want this company to
sponsor a drug study,

for two children whose father is
an executive of this company?

Have you never heard the
term "conflict of interest?"

It has nothing to do with a...

Do you know what the FDA
would do if they found out?

There is strong scientific
justification for this study.

There is great research value.

I'm a doctor, John. I
know the research value!

But you guys just can't go off
half-cocked without consulting us!

And I'm sure that if we just go
and talk to Erich, we can...

Erich already knows.

- He's furious about being blindsided.
- I didn't try to blindside anyone.

This is the reason why we
have a reporting structure,

why we have established
procedure, why there is protocol.

You heartless,
bloodless machine.

You just have to fight me every
step of the way! Don't you?

You just hated it when I brought the
kids with Pompe to the doorstep!

You weren't thinking about those kids when
you put your children into that program

and jeopardized a decade's worth of
research investment made by this company!

This is not about a
return on an investment!

It's about kids,

kids with names, dreams,

families that love them.

You've jeopardized your chances of
ever getting your kids treated.

I'm not arguing
science with you!

On every level! On every
level, you've stood...

I was just drafting a letter of
apology for senior management,

but I guess we're
past that point.

I just spoke to Erich, and we are
terminating your employment.

Okay, I'll pack up my stuff.

Just one thing, John.

I may well be a tight-ass
pencil-pushing company man,

but I resent being
called heartless.

- Look...
- Just let me finish.

The reason we're terminating
your employment,

is to eliminate the
conflict of interest.

This strategy was brought to my attention
by our colleague, Dr. Stonehill,

in rather crude terms.

This will allow the
sibling trial to proceed

for its purely scientific value.

Have your desk cleared out
by the end of the day.

Kent, what's with the...

I wanted to make sure you didn't punch
me out before I could tell you.

Well,

- thank you very much for firing me.
- My pleasure.

- I never liked you.
- Likewise.

Hey, you guys, bring
anything you want extra...

- Mom! Mom!
- What?

- Can I bring the bow and arrow?
- Yes, yes.

Hey!

John, what...

What?

We have a usable enzyme that's
ready for clinical trials.

When? When will it be ready?

Megs and Patrick start their infusions
before the end of this month.

- Oh, my God.
- Yeah.

Oh, my God.

John.

Hey, John, Daddy's here.

- Oh, hi, guys.
- Hey, Dad.

Why is Mommy sad?

Not sad, baby, so happy.

So happy.

Why is Mommy being so weird?

Well, it's because we got
the special medicine

for you, Megs, and for you, Patrick,
and you're gonna get it really soon.

That's great!

So, who wants to
push the button?

Megs, Patrick, you ready?

When will we know
if it's working?

Lt'll be a while, honey.

It's not pink.

Excuse me? Your Uncle
Bobby is here.

I don't know.

- You can go back if you like.
- Okay.

- John.
- Uncle Bobby.

They wouldn't let me in
unless I was family.

- Some things for the kids.
- Thanks.

Sleeping, huh?

Hey, thanks for coming.

I'm a scientist. Gotta
track the experiment.

I wish your enzyme was the
one that passed the test.

But the one the kids are getting,
it's the right one, right? I mean...

It's gonna help them.

Yeah, you guys have done
everything humanly possible.

We just have to see
what the tests show.

You and I have had
our differences,

and I just want you
to know something.

I want you to know that...

- Yeah.
- Don't interrupt.

Okay.

I want you to know that
I appreciate everything

that you've done for
Megs and Patrick,

and I'm never gonna forget
it for the rest of my life.

Not gonna kiss me, is he?

I will restrain him.

Don't tempt me.

Daddy loves SpongeBob,
Daddy loves SpongeBob.

- Stop!
- Daddy loves SpongeBob.

Guys?

What's going on?

What's so funny?

What are you laughing at?

Sugar.

It's a sugar high.

The enzyme's breaking down
the sugar in their muscles.

- The medicine's working?
- Yeah.

John.

Megs!

Hi.

- John, drive safe!
- Enjoy the ride!

Rock and roll!

- Bye! Have fun.
- Bye!

Yes!

Yeah! Yeah!