All language subtitles for 20260620 ChatGPT + mRNA疫苗幫助治療狗狗癌症｜澳洲鏟屎官真實案例 [Yolo 街]

The well-behaved dog in the frame is named Rosie

An eight-year-old female mud

A few years ago Paul rescued her from an animal shelter in Australia

Since then

Rosie is Paul's best partner

Best Mate

A year ago

Rosie was given a death sentence by the vet

Diagnosed with cancer

Having surgery

Undergoing chemotherapy

Also undergoing immunotherapy

All efforts proved futile

The vet said

Rosie has only a few months left

This Australian dog owner, determined to save Rosie

He came up with a crazy idea

Open ChatGPT

Ask what options there are

This is Rosie after treatment

An Australian dog owner with no medical background

What makes it possible in just a few months

to complete what would normally take ten years of medical research

to design an mRNA cancer vaccine for dogs

What kind of god-tier interaction did he have with AI behind the scenes

this crazy lab-rat plan

Could it unlock another option for humans

a new heavyweight in defeating cancer

Please sit back, everyone

This episode we go straight to real people and true stories

Australian pet owner AI dog-rescue story

A real case that breaks medical norms

While we are at it

When AI becomes a research assistant

Future humans

And is there really a chance to avoid the term terminal illness

Say goodbye

The story's starting point

Starting from a few years ago in Sydney, Australia

About four years ago

Rosie was four years old then

He noticed lumps on both of her hind legs

For a full year

The vets assured him

it is just a common rash

Do not worry

But those tumors kept growing bigger

By the time Rosie was five

A thorough checkup yielded a confirmed diagnosis

Mast Cell Tumor

Mast Cell Tumor

Common in dogs

But also one of the hardest malignant skin cancers to treat

Pet owners watching

You will understand

Pets are family to us

And Rosie is Paul's constant best mate

Best Mate

Paul wouldn't give up

So he set off on a long cancer-fighting journey with Rosie

Conventional cancer treatments

There are only three options

Surgery, chemotherapy, immunotherapy

Paul spent money like water

Tried everything

Countless surgeries

Chemotherapy wore Rosie down

Even immunotherapy

But it all failed

The vet told Paul something no owner wants to hear

Also the hardest thing to hear

Sorry

Its cancer has already spread

Currently in an incurable stage

We can at most give it a few more months of life

Rosie was officially abandoned by conventional medicine

If an ordinary person reached this point

They may have to accept

But in his despair, Paul suddenly hit upon an idea

Since conventional medicine isn\\

Why not try it

It was 2025

The whole city was talking about how AI could do anything

Paul stared at the computer

He thought
If that is the case

Could the AI guru save Rosie\\

Then he opened ChatGPT

At first he was just like us

to ChatGPT

to understand the complex veterinary information

and explore what other treatment options exist

But

Nobody expected

As Paul dug deeper into the leads ChatGPT gave him

Even started contacting Australia\\

In his mind

he began to believe he could personally develop a new antidote for Rosie

This move

In the eyes of many doctors at the time

Unthinkable

An amateur

A layperson trying to rely on an online chatbot to save a terminal cancer dog that even top vets say is incurable

In doctors\\

Isn\\

Many would even think

Is this owner so desperate they\\

Crazy, right

But in Paul\\

He completely ignored what others thought

In his mind at the time

Only one simplest, most direct idea

I don\\

With this stubborn determination to see it through

The whole thing suddenly took an unbelievable turn

A medical miracle that even OpenAI CEO Sam Altman would post praising

has officially begun

Someone who has never even looked at a DNA sequence

a regular pet owner with no bioinformatics training

Where did the courage come from

That he could help Rosie

to develop a new cancer drug

In fact, the moment Paul opened ChatGPT

He had unknowingly stepped out of

the bounds of traditional medicine

Initially, he just wanted to use AI as a medical dictionary

to help translate terms

Paul at that moment on DNA and RNA

I have no idea what cancer vaccine this is

Who knows ChatGPT in conversation

Paved a way out for Paul

He tells Paul about modern technology

It can truly be tailored for Rosie

Her personalized mRNA cancer vaccine

The premise is actually simple

Paul only needs to fetch Rosie's tumor gene data

ChatGPT as an AI can help decode the vaccine formula

This sounds like a science fiction suggestion

It even woke a father who had hit a dead end

Traditional medical logic is like dining at a tea restaurant

All Meal A, Meal B, and Meal C

Big pharma develops a chemotherapy drug

Used by tens of thousands of cancer patients at once

But cancer cells are the universe's most cunning chameleons

Every tumor mutation in every dog and person

Each one is actually unique

Conventional drugs can't treat Rosie

Because all of Meal A, Meal B, and Meal C

None of them suit it

If that is the case the only way out is

To make Rosie a globally unique one

The one of a kind that belongs to her

a dog's personalized mRNA

cancer vaccine

Neighbors, we've endured COVID-19

Believe in the term mRNA vaccine

won't be unfamiliar anymore

But we are here

Quick recap of what it actually is

How it differs from traditional vaccines

It is not a live attenuated virus

Injected into the body

In essence

It is the feature data of the top fugitive

Sent into your body

Once the vaccine enters the body

Your immune forces will act with precision

Like a wanted notice

Immediately follow

The features on the list

All forces mobilized

Closing in on you completely

The enemy you want to wipe out: COVID-19

Either way

Cancer cells as well

But for this warrant to exist

Clever you should have thought of

Before the warrant is issued

First you need to know what the top fugitive looks like

What it actually looks like

So

Paul without a second thought

follows ChatGPT's instructions

Immediately contact Australia's top research institutions

Genomics Institute at the University of New South Wales

Spending a few thousand AUD

The request is simple

Rose's tumor tissue

Then perform whole genome sequencing

Genome Sequencing

Read every DNA code inside

The associate professor Martin Smith who led the center at that time

When I received Paul's email

At first, my mind was full of questions

The professor wants

Hey

You are a layperson

Do you have any idea how huge the genome data is

Once you have it

how to deal with it

But Paul was sure then and told the professor

Don't worry

data analysis work

I can handle it

The data the research center handed to Paul

Not a miracle drug

But instead several huge digital files

When Paul opened these files

They are strings springing out of ATCG

An endless sea of characters

How many letters are here in total

The answer is about 150 billion

Just how big is 150 billion

If we print it as a book

It could fill the whole university library

Paul faces

these completely irregular ones

a scrambled alphabet salad

to find the one letter copied wrong

causing Rosie to form a tumor

People like us reach this point

Facing this mountain of data

Willpower may be almost gone

But the turning point is

Paul is not just an ordinary IT guy

His real identity

is actually an IT guy who specializes in machine learning

What he is best at

Of course not a surgeon

He deals with data every day

So in his eyes

Big data problems are well within his reach

Since the human eye can't read all 150 billion letters

Then hand it to the fastest AI

Paul enters round-the-clock seclusion

Every day he faces a glowing screen

Treating ChatGPT as his superbrain

Give this data, like a stack of scriptures, to AI for sorting and analysis

AI suddenly becomes Paul's best medical assistant

Help him precisely search through the massive data

Rosy cancer cell neoantigens

Neoantigens

What are neoantigens

Normal cells are ordinary, law-abiding citizens

And cancer cells are fugitives hidden among ordinary citizens

This so-called neoantigen

is actually the fugitive's unique feature

If AI can pinpoint it precisely within 150 billion letters

Find the fugitive features

The vaccine can become a precise arrest warrant

Teach your immune system to use these features to catch them

That is how it works

It would normally take a long time to organize

Through day and night interactions between Paul and ChatGPT

The data mountain starts to be dismantled layer by layer

That 150-billion-letter celestial manuscript begins filtering, slimming down

Finally zeroes in on a specific gene mutation

This gene is called the CKIT gene

That moment

Paul knew the first battle had been won

He finally, in the vast sea of data

He precisely grabbed the tail of this formidable foe, the cancer cell

But the letters of the gene mutation

Only the fugitive's textual description

This is like what is written on the wanted notice

A mole on the suspect's face

But the problem is

Where is the mole located?

Left side, right side

Or is it on the nose?

If there is no 3D location

Rosie's immune system can't make sense of it

nor can they act on it

So

The tricky problem Paul must solve next

is how to turn this string of text into a concise form

a string of text becomes a precise 3D location-based wanted notice

At this point, Google's turn

another AI marvel that turns data into 3D structures

AlphaFold takes the stage

After locking onto the CKIT gene

Paul, though, has the fugitive's flat data

But he knows a string of flat gene letters alone

cannot be directly turned into an injectable drug

Because the next hurdle is predicting the 3D structure of proteins

In the microscopic world

Structure equals function

DNA is only a flat blueprint

The real culprit is the 3D protein

You have to design a bespoke vaccine

With the features of this top fugitive

which is the cancer cell's new antigen

which are a bunch of mutated proteins

Then you must know in 3D space

what these mutated proteins actually look like

In other words

you must precisely pinpoint the spot the cancer cell exposes

where exactly it sits

Pharma companies used to spend years and money researching a protein structure

But Rosie could not wait

So Paul deploys Google's AI marvel AlphaFold

Many people may not have heard of AlphaFold

To put it simply

It is the world's most powerful 3D protein modeling tool

Things that used to take years

Why it can be so fast now

Because Google made a decision

They made AlphaFold freely available to the public

Today, almost all top biology labs worldwide

use this AI tool every day

with this protein 3D modeling tool

The whole process is divided into three parts

Step one

Paul must first navigate the 150-billion-letter data mountain

Precisely filter the seven strongest, easiest-to-recognize new antigens

In the wording of a wanted notice

He successfully locked onto the suspect

Step two

He inputs the 2D data of these seven features into AlphaFold

AI runs a computation

and produced precise 3D models for all seven features

Step three

Paul then has ChatGPT perform cross checks

Cross-check each of the seven 3D models individually

Finally confirm these seven markers

the seven core, inescapable features of this cancer cell

But reality is not that glamorous

Do not think Paul is hiding at home fighting alone

In fact the whole process is a tight cross-disciplinary collaboration

During the months designing the vaccine

Paul has been working with Martin Smith, UNSW gene sequencing expert

Paul has been working with Martin Smith, UNSW gene sequencing expert

and Professor Paul Thorderson, director of the RNA Institute

Maintaining close communication and collaboration

Top scientists, an AI brain, and a father who will not give up

This tailor-made cancer cell that outsiders once fantasized about

Step by step, it becomes reality

After months of effort

Vaccine design finally complete

As soon as the design is finished

he immediately goes to the director of the RNA Institute

Professor Thordarson

Professor Thordarson was initially somewhat skeptical

Because moving from development to production takes time

He worries Rosie will not be able to hold out that long

But after his team

the professor felt this non-scientist-made design

was quite stunning

on top of that, his institute had never worked on a cancer vaccine

so they all clicked right away

but just as Paul thought he had beaten all defenses

as he prepared a decisive shot to save the day

the referee suddenly rushed out to blow the whistle

and intercepted him forcefully

This referee is not from science

nor from AI

but from the oldest invention of our human society

the trickiest invention

bureaucratic admin hell

in Australia

you write a software patch to upgrade the phone

nothing at all

but if you want to inject a string of newly designed chemical molecules into a living dog

the laws and paperwork involved

thicker than a dictionary

Paul must apply to the university and government ethics boards for animal ethics approval

the whole plan becomes a two-front battle against time

on one side, top labs are fully ramped up

This is the precise manufacturing process that turns digital formulas into real weapons

The scientists spent two months

On the other hand, Paul bears the bureaucratic paperwork alone

During these months, this IT guy would come home after work every day

just sitting in front of the computer

filling those endless government filings

He even laughs at himself

to deal with this stack of ethics approvals

He spends several hours a day filling them out

It dragged on for a full three months

The workload was more than the vaccine design itself

In the end

the approvals and the vaccine

But fate played a joke on him again

as Paul held the syringe and medicine

as he was in high spirits preparing to save Rosie

The research center told him, Sorry Sir

We are the research center

Only responsible for R&D and manufacturing

Not authorized to vaccinate your dog

Next

Paul rushed to the regular vet Rosie usually goes to

The vet took one look

and immediately shook his head in alarm

saying this is an untested experimental drug

Who would take responsibility

Months of hard work

The high-tech solution worked

Survived the bureaucratic paperwork

Finally

it was stuck at this spot where no one dares to inject

No way

At this point

Rosie's leg tumor had started to worsen

and it even bleeds

life was clearly counting down to the end

these breakthroughs created by IT guys, AI tools, and a top-tier science team across disciplines

Finally, can they be injected into Rosie's body

Watching anxiously as the vaccine is prepared

But Rosie can't get the shot

Fortunately

Paul via his contact in the U.S.

found The University of Queensland

Professor Rachel Alvina, Vice Dean of the Veterinary Science Institute

Professor Rachel is an expert in animal immunotherapy

She said if Paul can bring Rosie to Brisbane

she can give Rosie the shot

That moment

Rosie's leg tumor had grown very large

Bleeding

The situation was dire

So Paul didn't hesitate

and drove with Rosie all the way from Sydney to Brisbane

And at this moment

Paul also pulled off a bold two-pronged strategy

Apart from his homemade mRNA vaccine

He, through Professor Rachel,

another Nobel Prize–winning immunotherapy drug

immune checkpoint inhibitor

immune checkpoint inhibitor

Ladies and gentlemen

This tactical logic is actually very clever

To understand

cancer cells can run rampant inside our bodies

There are actually two major rogue defenses behind it

The first line of defense is invisibility

Because cancer cells are also our own cells

it can often fool our own immune army

when it is one of us

go straight through

The second line of defense is hypnosis

Even if immune cells approach it they plan to destroy it

they plan to destroy it

cancer cells release hypnotic codes

making cancer cells suddenly unable to see it

That is why conventional treatments often fail

But this time Paul combination therapy

to wipe out both lines of defense in one go

they use immune checkpoint inhibitors

to disrupt the second line of defense

breaks the hypnosis

then follows up with his own AI vaccine

break through the first line of defense

directly insert a warrant listing the 3D features to identify it

one to awaken the army

one to lead the army to find targets

at the University of Queensland Hospital

Professor Rachel Alvina will deploy this perfect combination

injected at multiple sites around Rosie tumor tissue

At this point

Some viewers may recall

Hey
Bonnie

In Chapter 1 you said Paul was already with Rosie

Had immunotherapy already?

but there was no result

That is right

The literature does not detail the failure specifics

But based on current medical logic

We can reasonably infer its cause

The standard immunotherapy Paul gave Rosie at the time

likely it was simply using this checkpoint inhibitor

These inhibitors did wake up the immune army

But the problem is there was no warrant on hand

Not knowing what the enemy looks like

rush out

a sea of people

the immune army still cannot tell which cancer cells to target

ultimately they returned empty handed

Okay

Back to Rosie

The first few days after the shot

Rosie more tired than before

One day after returning to Sydney

Paul suddenly finds a lump on Rosie leg

those large tumors suddenly began

to swell violently

This situation

for an ordinary person it might make the legs go weak

But his rational thinking

he feels hopeful

He calmly analyzes that this swelling

may be the immune system got the wake up call

begins a frantic siege on cancer cells

causing local inflammation

This is actually a very good signal

This is actually a very good signal

Sure enough

Not surprisingly

A few days later

A miracle happens

Those swollen tumors

suddenly, like burst balloons

rapidly shrink

Paul describes himself in the interview

he says

In those few short days

I really felt like I was seeing those tumors with my own eyes

as if melting away

watching her feet

I actually started seeing her ankles

I actually started seeing her ankles

Holy crap

it's working

Paul said he was so excited at the time that he shouted

went through so many rounds of chemotherapy

the late-stage malignant tumor stayed stubbornly unchanged despite so many rounds of chemotherapy and surgeries

Under a two-pronged attack of AI vaccines and checkpoint inhibitors

It could be seen with the naked eye as it rapidly shrank away

Even more amazing

Rosie's spirits recovered

Back to the happy dog she used to be

Of course Paul breathed a sigh of relief seeing Rosie

But medicine is always rigorous

Professor Paul Thordarson and Paul later spoke to the public with great candor

While there was improvement, it's not a perfect cure

In medicine this is called a partial response

Most of Rosie's tumors have melted away

But some cancer cells remained resistant to treatment

Even to this day

Paul still uses the data at his disposal

to develop the next generation of booster shots for Rosie

booster shots

to tackle those residual drug-resistant cancer cells

Cancer is a long war

You may not win in a single shot

But at least it shows that

Paul has found a way forward we might not have known before

The battlefield where Silicon Valley and biotech giants are now pouring money is right here

When bioscience becomes information science

Unknown mysteries that would have taken years to solve

compressed by AI into days of data sorting

Many people now worry AI will take away their jobs

But when we look at Paul

Is technology creating new possibilities between doctors and patients?

The future

Will what Paul did become a new kind of job?

The eventual elimination of humans won't come from AI

Weaving miracles

nor is it cold, impersonal technology

But it's those who know how to use AI to protect the ones they love

This episode ends here

Everyone

What new opportunities do you think AI will create in medicine or other fields in the future?

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See you next time, bye