All language subtitles for Charite s04e03 Hoffnung.eng

It's 39 degrees Celsius outside.

Do you realise
how ridiculous I look right now?

Look, it made
the other bacteria grow.

Mrs Abdul-Hai,
I'll think of something.

We're performing
a kidney transplant

on Felicitas Abdul-Hai today.

We could lose our jobs.

The inflammation has to come down.

What's your recommendation?

Stop the reform!

Stop the reform!
Stop the reform!

Hey, hey, Lou!
Wait a minute.

I don't have time.

No time for the good cause?

The good causes.

Come on, Lou.
We need to set an example.

Piss in the government's soup
when they trample on justice.

You're still full of shit.

Hey man, you used to be
on the right side.

And that got me in deep shit.

I'm sick of your bullshit.

You'll come back!

Stop the reform! Stop the reform!

- Maral?
- Dylan.

We've been going about this
all wrong!

Have we?

The paleobacterium
isn't the problem,

it's the body's immune response.

This leads to damage to the organs

and the microbiome.

But from where?

If we use the paleobacterium

correctly, in the gut,

- not in the blood...
- Yes?

Then it controls the growth
of the other bacteria.

The paleobacterium

isn't the poison, but the cure!

Mr Baldwin needs more
of this bacterium.

Multi-resistant germs

cannot be integrated.

You have to fight them.

My finding proves the opposite.

No. There's a man out there
fighting for his life

and you want to give
his relatives hope

because it suits your research?
That's hubris, Maral!

We'll start with the phages.
They've been tried and tested

and weren't just made up overnight.

My approach is validated.

Look at this.

Multiplication in progress.

I made an AI simulation.

Here you can see: Eubiosis

is produced in a few hours.

AI cannot replace a study.

I've already got drugs through
the FDA with AI simulations.

We're not in Boston.

I don't need your approval.

I will treat Mr Baldwin
as I see fit.

Great collaboration.

Morning.

Good morning.

We'll have to completely rethink
your husband's case.

Didn't Dr Van Boeken want to do
the phage treatment?

Er, right, but I don't think
that will work.

You see, for him

it's about fighting the bacterium.

Whereas my aim is

to integrate it into the microbiome
in larger quantities

so that it
can activate regeneration.

We're dealing with a completely
new type of bacterium here.

Let me explain it to you.

So...

So, let's say this sphere here

is the bacterium,

the paleobacterium.

It was trapped in ice
for thousands of years

but was released by global warming

and washed into the North Sea
by deep currents.

And through this tiny little cut
in your husband's finger,

this bacterium

entered his bloodstream
while he was diving.

So, my pad is his bloodstream.

The bacterium enters his entire body
through the blood

and triggers an overreaction
of the immune system.

This disrupts the microbiome,

that is, these tokens here.

The bacterium now enters the
microbiome through the bloodstream.

The unbalanced microbiome

fires up the inflammation,

causing the immune system
to react even more.

The microbiome exacerbates
the inflammation,

creating a momentum of its own
that can no longer be stopped.

However, if we now...

introduce the bacteria

not through the blood,
but directly

into the microbiome,

it suddenly no longer
has a destructive effect

but...

a reconstructive one.

Sounds like hocus-pocus to me, sorry.

Have you ever done this before?

Your husband's the first.

As no conventional therapy
works for him,

he is a hardship case.

And in a case of hardship,

we're allowed to try
yet unauthorised treatments.

It's an individual
treatment attempt.

You haven't tried
all the treatments yet.

Based on my evaluations,

this approach is the only way
to save your husband.

We want to try
Dr van Boeken's suggestion.

You know the budget meeting
is coming up?

I'll be there shortly.

What's wrong?

I want to try
a treatment attempt with a patient,

but Dylan's trying to stop me.

He's even turning
the relatives against me.

So what next?

Well, nothing.
It's stressing me out.

That's stressing you out?

You really don't sound
like a boss right now.

You know what, just forget it.

Listen, you've chosen
a difficult profession.

It requires decisiveness,

a strong will
and the courage to take risks.

Believe me, I know
what I'm talking about.

Yeah.

You don't let anything derail you.

I always do
what I think is right, yes.

- I know.
- Yeah.

And if you're that intimidated
by a colleague,

then maybe you're really not right
for the position.

Third attempt complete.
Run five.

No physical reactions measurable.

Wake up.

Hey Lars,
the session's about to start.

I'll be with you in a minute.

OK, I'll get started.

Ferhat, where are you?

Lars Kirch.

Williamson Cyber
Stimulation Therapy, fourth attempt.

Here.

Throw the ball as far as you can.

I'm a pro surfer,
I'm not here to play around.

I want to get on a real board,

with real wind, real water,

the real smell of the sea!

It just smells like...

hospitals here.

I can see if I...

can programme another smell.

Now please throw the ball.

Hey, maybe we'll have
a little success today.

Alright.

No response.

Well?

Here, have another shot.

No response.

No response.

- It's not working.
- Not yet.

Come on, just keep going.

Marlene.

I was just at the budget meeting
with Emilia Bonetti.

She's taking a pretty tough line.

Some programmes are even being cut.

All the more important
we keep going!

How's Mrs Abdul-Hai doing?

Is the aftercare working?

Yes, she's walking
and washing herself.

Ah, very good.

We've been very lucky.

We've done a great job.

Seda! We're understaffed
and not well equipped.

Better to take a risk
than do nothing.

We helped a patient,
that's the only thing...

Not a solution!
Do you want to operate

on everyone
who falls through the cracks?

The problem lies elsewhere.

I know, but you still have to

do something...

Hello?

Hello, can you hear me?

Yes. I was just on my way
to the cooling spaces.

I'll be fine.

- Let me take your bag.
- It's OK.

Everything's OK.

- What's wrong with your leg?
- Nothing...

It's nothing.

You're coming with us.

Delayed healing of a tibial fracture

with subsequent

development of pseudoarthrosis.

It isn't that bad.

No! No, it is bad.

You had a bone fracture in the tibia

that didn't merge stably.

A defective joint has formed,
a so-called pseudoarthrosis,

hence the swelling
and pain in your leg.

Your leg needs operating on.

Oh no. Please, no.

No operation, please.

But you can't go on like this.

Bolton, did you say?

B-O-L-T-O-N, Gillian?

I can't find you in the system.

I...

I have no insurance.

I came here two years ago
from LA and I just have...

a tolerated stay permit.

Did you flee from the fires?

And your family?

We were separated.

My mum and my son

ended up in France.

I've been trying to get them...

to join me ever since.

Don't be afraid.

We'll take care of your leg.

We have to fight
the immune reaction -

not the paleobacterium.

That's why the phages won't help.

We have to rethink.

The phages are the most effective

and reliable means we have

against multi-resistant bacteria.

And this paleobacterium
is multi-resistant.

Why can't you see
it's not about the pathogen?

Phage therapy
will only cost us valuable time.

We must start
the ITA immediately

to save Mr Baldwin.

The time pressure is precisely why

we can't keep experimenting
with unreliable methods!

And you're sure it will work?

Of course I can't guarantee it 100%.

But I'm very sure

that the inflammatory reaction

cannot be stopped by

anything other
than the bacterium itself.

The patient will die

if we don't try
this new treatment.

Emilia.

Do the treatment attempt.

You can't be serious.

The Charité wouldn't be the Charité

if it didn't keep
breaking new ground.

We promote progress here.

If such an opportunity arises
with Maral's trial,

then we will get behind it.

That's one of the reasons
we brought her here.

Thank you.

Let's hope that your
obsession with progress

isn't to the detriment
of patients.

Wait a minute.

I'm going out
on a limb for you here.

The first sign
that it's ineffective, you stop,

understand?

Yes.

Once you have
the relatives' consent,

you can get started.

I need to talk to you again.

Due to your husband's
high inflammation levels,

it's only a matter of time

before other internal organs fail.

Phage therapy
won't be able to help here

because it's fighting a problem

that is simply no longer the cause.

The new treatment attempt
is his only chance.

And what are the chances?

I can't say exactly.

But I'm convinced that it
will save your husband's life.

But Dr Safadi,

please, don't get me wrong,

you're certainly
an excellent doctor.

But you also make mistakes
and even you can be wrong.

But if I am right,

not only will it save your husband,

but other infected people
in the Netherlands.

We can't predict how many infected
people there will be globally.

Ah, right.

So this isn't about Piet.

This is about your reputation!

And you want to turn him
into a guinea pig!

- No, no.
- Oh, Rupert, please!

Oh, I'm sorry.

- He's a bit haywire.
- Yes, I am.

You won't get our approval!

- It's not just your decision.
- Or yours.

I'm responsible for Piet.

Do you really want to risk his life?

We agreed on the phage therapy.

Please, please, please.

Maybe you'd like to discuss this...

outside in private.

Doctor?

Doctor Safadi?

Mr Baldwin.

Rup... and Evelyn...

Too difficult...

Decision...

The decision is too difficult
for Evelyn and Rupert?

Yes.

Do the treatment attempt.

I... I don't want to die.

OK.

I need your consent in writing.

OK, yes.

Er, what is it?

Sit down.

How are you?

I heard about the success
of your memory trauma therapy

with the little patient.

Congratulations.

Is that why I'm here?

No.

I have some news.

The research committee at Harvard

has changed their priorities
for external funding.

They're pooling some of their funds

to further increase the budget
for Planetary Health.

Does that affect my research?

Yes.

The commission has decided
to phase out

your Locked-in project.

What?

Why?

The commission's reasoning is that

progress is insufficient
and the costs are too high.

That's not true at all.

We're on the verge
of a breakthrough.

I'm sorry, Ferhat.

I'm just the messenger.
I can't do anything else.

Yes, the Charité
has to make up the money.

That's impossible.

The heat damage and the reform
are already costing enough.

My research will set new standards
in many areas.

The participants can already move
in the cyberverse

and we're so close to reading

their movement patterns
from the brain,

transferring them to the muscles

and feeding the sensory signals
back to the brain.

I'm sorry.

But your research question is simply

no longer considered so urgent
at the moment.

What am I supposed
to tell my patients?

"Sorry guys, Locked-in syndrome

just isn't that urgent now".

I can't see you
at all right now, sorry!

I can understand your fears
about your husband.

- But I'm sure...
- It's just...

no matter how sure you are,
there's no guarantee

that this will work, OK?

I'm trying to convince him.
I'm really trying!

Great, now you're teaming up.

You're not getting a yes from me.

To be honest,
that won't be necessary anymore.

When I was
with your husband earlier,

he spoke to me.

He asked me to start
the treatment attempt.

Anyone can say that.

I have his consent in writing.

How did you get into the programme?

Layla let me in.

Can you stop a minute?
I need to talk to you.

What's up?

We have to pause our project.

For how long?

Until we've found a new funder.

But that could take forever, right?

Fuck!

Do I have to go back to the home?

Listen, I'll do anything...

I'm not going back to that dump!

Wait, wait... throw it again!

Your... your hand moved.

Throw!

Movement detected.

I'm throwing!

Come on, keep going!

I'm throwing!

OK, let's take a break.

This... this is crazy!

Your anger must've been the key
to the impulse.

We can't cancel the programme now!

Yes, you're right.

What's going on?

You wanted a research success?

Allow me to introduce
my patient Lars Kirch.

He moved his hand today
for the first time in five years.

I have all his data.

Here.

The Charité must continue
to fund the project.

There.

The spikes are Lars'
movement patterns.

Yes.

Please excuse us for a moment.

Come with me.

I'm really pleased that

you've made such progress
in such a short time,

but I also know how fragile
such successes are.

Even if I do stand up for you,

we're not talking about an extension
of a few weeks.

Mr Kirch isn't going to get up
and go home next month -

if he ever manages to do that again!

It will take years
and you know that.

Internal research funds have to be
released for the long term.

For a niche project
with slow results.

I'm sorry,
that's just not realistic.

Fever 39.9,
tachycardia 130 BPM,

hypotensive 60/40 mmHg,

peripheral saturation 85%.

It's time. Good.

We're going to start now, OK?

Start with the microbiome therapy

by injection into the gut.

We'll know more
in about two hours.

Good. Thank you.

CHARITÉ - SHADOW CLINIC

You should become
a surgeon after all.

But it still can't go on like this.

I hope you realise that.

Yes...

Did you switch off your locator?

Oh.

- Seda!
- Yeah, yeah.

Locator off.

What are you still doing here?

My Locked-in project
is being cancelled.

What?

Despite having made
a huge breakthrough.

Harvard has cut
its third-party funding.

So what now?

Now...

I'll send everyone home and then...

I'm left with nothing.

Oh, come on.

There must be something else
in your life.

This project is my life.

Hey, why don't you go out!

Go eat, go dancing, go drinking.

Experience something beyond
just the Charité.

With whom?

With me?

Yeah, well not everything
at the same time.

- OK.
- Food...

Clean Meat?

- Wednesday evening?
- OK.

OK.

Message from Maral.

Hey, I can't make it today,

I'll be back later.

Call my sister.

Hey Julia, what's up?

Hey.

I just wanted to say hi again.

Ah, I'm just taking Zac to sports.

Can I call you back later?

What did you say, Zaggy?
Yes, I know it's really hot.

But we have to go now.

Sorry Juli, let's talk later, yeah?

OK, sure, no problem.

Everything OK with you?

Yes, everything's great.

And with Maral?

Also fine.

She's... um... is on the trail

of another medical discovery.

So all's well, then.
I'll call you later, OK?

- Alright. Bye.
- Bye.

Shit.

Oh God.

- Do something!
- We're taking care of it.

Your hazmat suit?

No time for that.
Come on, help me!

I've got it. I've got it.

The dose was too low.

We need to give him more.

Maral, that's enough now.

Breakthrough at the Charité.

The doctors were able to prove

that the so-called paleobacterium

cannot be transmitted directly
from person to person.

The mysterious pathogen
remains highly dangerous.

New cases are occurring
almost daily,

especially in northern Europe.

Many of them are in mortal danger.

Public pressure on the
scientific community is growing.

Also in Berlin,
where a small group of doctors

have declared war

on the deadly bacterium.

His inflammation levels
have fallen slightly.

And as the bacterium obviously
doesn't spread

from person to person,

he doesn't have to remain
in the isolation ward.

- That's already a start.
- He's in a coma!

You act like
that's a good thing.

An induced coma
is not a bad thing per se.

It takes the pressure off

so that his body

can fully focus on healing.

I can understand your concerns.

But I assure you,

we'll do the right thing
for your husband.

Excuse me.

Yes?

You look exhausted.

Is that why
you wanted to talk to me?

- You can't go on like this.
- Of course I can.

If you increase his dose again,
he'll die.

I admit that the dose increase isn't

as straightforward as I thought.

- Yes.
- But I'm getting there.

It's irresponsible -

medically and ethically.
I'm going to see Emilia.

- Wait!
- What?

If Mr Baldwin's condition
doesn't change

by tomorrow morning,

then you can take over.

Twelve hours.

Looks good so far.

But you mustn't put any weight

on it for the next four weeks.

OK.

I'll give you some crutches.

- Thank you.
- Hello.

We're looking for Gillian Bolton.

Er, I can't give you
any information there.

Yes, you can. In fact,
you're legally obliged to.

Are you Gillian Bolton?

You were registered
in the system yesterday.

- What do you want from her?
- To take me.

I'm being...

deported.

I thought you had
tolerated status?

Not for a long time.

But why did you...

Then come with me, Miss Bolton.

Stop! She can't walk!

What's going on?

Theo Wallin, Return Management
of the Immigration Office.

This is my ward.

You can't just come here
and cart my patient out.

If your patient
is in the country illegally,

we can do that.
Please step aside.

But she needs proper aftercare.

Her leg will get infected.

Someone else will take care of it.

You can't do this.

This is insane!
It's negligent.

You're responsible.

It's OK, really.

It's OK.

Just a minute.

Come here. Slowly.

Any belongings?

My bag.

Thank you so much for everything.

Just wait a minute!

I hope you can be with
your family again soon.

Everything will be fine.

Goodbye.

Everything will be fine.

Goodbye.

- Hey Owen.
- Hey Seda.

Paris Marathon again this year?

Every year.

Hey, erm...

- I have a hypothetical question.
- Hmm?

If a fellow runner
were to get injured who,

let's say,

didn't have health insurance,

would you treat the woman
off the record?

It depends... on the injuries.

I'm not a surgeon.

I'm an anaesthetist.

Yes, of course,

but that doesn't matter now.

The question is purely ethical.

You mean,

would I help people...

who've... who've fallen
through the cracks?

Well, of course.

Good.

Hey, can I ask you something?

How many times have you had

an operation cancelled
because the scoring was too bad?

Twice, I would say.

How do you deal with that?

Well, I don't operate.

- Right.
- Right.

Hey, I need you...

urgently.

I was having
an important discussion.

I know everything.

You do?

You were trying to get Ivana

to conspire with you.

What are you talking about?

Listen, I know about these things.

Remember the fracking decision?

Yes.

I was part of the
Chancellery hacking back then.

One of the demonstrators
in front of the hospital

was also part of it.

But they all ended up in prison.

Yes, exactly.

We served two years -

for membership
of a terrorist organisation.

But we don't need a terrorist here.

We treat people,
not plan attacks.

But you're planning something else,

to do with the reform, right?

Why are you telling me this?

Because I want to join you.

I'm struggling with these new
developments as much as you.

Really.

Let's say there was some kind of...

conspiratorial action...

Could you hack into
the hospital system and get us

intel on unused blood reserves

and infusions and stuff?

Of course.
I could've even told you that

Gillian Bolton
is on the deportation list.

Good.

Then welcome to the shadow clinic.

OK.

CHARITÉ VILLAGE - BRANDENBURG

You have a beautiful home.

Sometimes I wonder
if it really is...

my home.

Do you miss the States?

My sister.

Friends.

Oh, it's probably just
the new environment.

The environment...

aha.

I feel like...
I've somehow lost touch...

with Maral since...

we've been here.

We used to hang out
way more in Boston.

And now this whole thing
with Michel...

We have to accept it
when our children grow up

and go their own ways.

That's exactly what Maral says.

But I think she just wants
to do it differently to Seda.

You could be right.

The tension between those two
is unbearable.

Maybe they're just too similar.

Don't let your daughter hear that.

Seda hasn't had it easy in life.

She was very young

when she had to flee Armenia,
all alone.

How did you two meet, actually?

At the Love Parade.

Yes, it was love at first sight.

I then took care of Maral
to cover Seda's back.

She's always...

demanded a lot from herself
and others.

I didn't know any of that.

And you...

you are the best thing that
could've happened to our family.

And you'll make new friends here
in no time.

Just promise me
you'll look after yourself.

Hey, you two!

- Hello.
- So nice out here.

Ah, what a day!

Have a sip of that.

Listen, so...

- I'll get some more.
- Thanks.

Did you know that

Nils and Seda

met at the Love Parade?

I've had quite a day,

I don't want
to talk about my mum.

OK...

Did you talk to Michel?

Julia, I know how important
the matter is to you,

and I promise I'll talk to him,

- OK?
- OK.

- And when?
- Oh Julia,

it's all a bit much right now.

I make this...
this fascinating discovery,

and everyone, literally everyone,

is in my way.

And I don't understand why.

I'm off to bed.

What's up now?

Maral, you're so exhausting
right now.

But I'm sure you'll show everyone
in the end. Good night.

Whew, OK, erm...

As you know, today is the last time:

the last time looking at the sea.

The last time with sand
under our feet.

The last time with water
that isn't wet.

I'm...

so sorry
that we can't continue together,

because I've grown very fond of you.

I will do everything...

everything I can
to acquire new funding.

But it could take a while.

And until then...

I'm afraid I'll have to let you go.

OK.

Are you ready?

Yes?

Yes.

So, time's up.

His values are getting
worse by the hour.

I'm going to start the phages.

No, you won't.

Yes I will. We have a deal.

I'm in charge of Microbiology.

And I make the decisions here.

We'll see about that.

NEUROTECHNOLOGY

Where are you taking me?

I've got a surprise for you.

What is this?

You don't have to go to the home.

I've made a deal
with the management.

And you needn't worry
about the costs.

What's the point?

I... I thought you'd be happy.

Happy? Are you serious, Ferhat?

And what exactly
am I meant to be happy about?

That I can now raise my shitty hand

after all this time,

then find out that's probably
all I'll ever be able to do?

Or about the fact
that you lied to me

to keep me as
your little research monkey?

Oh no, of course
I should be most happy

that you're now salving
your conscience with this room.

But you know what?
I don't give a shit.

OK.

I didn't know that's how you felt.

I didn't lie to you about
potential successes.

But I obviously should have
clarified things more

to keep your expectations realistic.

I'm sorry about that.

I'll... leave you to it.

We'll talk later.

Maral? I need to talk to you.

Now?
I'm in the middle of a treatment.

That's what I want to talk about.

Your treatment attempt
is getting out of hand.

Did he tell you that?

He can't judge that at all.

Yes, he can.

I'm observing Mr Baldwin's condition
just as you are.

Maybe you're no longer objective
because you're in so deep.

Rubbish,

I know exactly what I'm doing.

Now let me get back to work.

I really appreciate
your thirst for research, Maral.

But it's getting dangerous
for the patient.

The treatment will stop now.

No, it won't.

And if that's a problem,
we can take it

to the Ministry of Health.

I don't think you'll get any support
from Nguyen right now.

I need to return to my patient.

He's not your patient anymore.

You're suspended.

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