All language subtitles for Decoding Watson - PBS American Masters 201933

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Would you like to inspect the original subtitles? These are the user uploaded subtitles that are being translated: 1 00:00:01,133 --> 00:00:05,900 ## 2 00:00:24,066 --> 00:00:25,500 -It's all for you. 3 00:00:25,533 --> 00:00:27,266 -Yes. 4 00:00:27,300 --> 00:00:29,566 -There he is -- the man of the hour! 5 00:00:29,600 --> 00:00:30,733 -How are you? 6 00:00:30,766 --> 00:00:32,000 -I'm fine. -Great to see you! 7 00:00:32,033 --> 00:00:33,166 -Cheese. 8 00:00:33,200 --> 00:00:35,266 -You have to smile for the cameras. 9 00:00:35,300 --> 00:00:39,800 -Happy birthday! -How 'bout a good champagne? 10 00:00:39,833 --> 00:00:43,233 -I discovered DNA through Jim Watson. 11 00:00:43,266 --> 00:00:44,866 I took a class from him, 12 00:00:44,900 --> 00:00:47,866 and after one hour, that was it for me. 13 00:00:47,900 --> 00:00:50,233 -Nancy! [ Laughs ] 14 00:00:50,266 --> 00:00:53,333 -I think he changed many people's lives that way. 15 00:00:53,366 --> 00:00:56,633 -Jim Watson changed my life! 16 00:00:56,666 --> 00:01:01,466 -He was clearly absolutely brilliant and very eccentric. 17 00:01:03,400 --> 00:01:04,700 -Look. 18 00:01:04,733 --> 00:01:06,100 -Oh, Jim! Mwah! 19 00:01:06,133 --> 00:01:09,466 -I had to be here and look alive today. 20 00:01:12,400 --> 00:01:15,333 -He was a genius who discovered the secret of life 21 00:01:15,366 --> 00:01:17,700 when he was 25 years old. 22 00:01:17,733 --> 00:01:19,733 It burst on the scene. There it was. 23 00:01:19,766 --> 00:01:21,366 Bang. Just there it was. 24 00:01:21,400 --> 00:01:25,300 -You could see it would be revolutionary. 25 00:01:26,833 --> 00:01:30,066 And, of course, it was. 26 00:01:32,933 --> 00:01:34,966 -It's a discovery of a lifetime. 27 00:01:37,933 --> 00:01:41,733 -It's certainly one of the greatest discoveries in science 28 00:01:41,766 --> 00:01:43,733 that's ever been made, and in biology, 29 00:01:43,766 --> 00:01:47,233 it ranks up there with Darwin and Mendel 30 00:01:47,266 --> 00:01:49,766 and then Watson and Crick. 31 00:01:49,800 --> 00:01:53,033 -Well, I wanted to do something big. 32 00:01:53,066 --> 00:01:54,866 That's all. [ Chuckles ] 33 00:01:56,133 --> 00:01:59,200 -This is the kind of scientist that people, 34 00:01:59,233 --> 00:02:01,766 in some ways, dream about, right? 35 00:02:01,800 --> 00:02:04,466 Trying to discover something that people care about, 36 00:02:04,500 --> 00:02:06,933 would have a lasting impact. 37 00:02:06,966 --> 00:02:09,433 There are sort of not too many people 38 00:02:09,466 --> 00:02:13,533 that I can think of that sort of had that moment. 39 00:02:13,566 --> 00:02:15,633 -The structure of DNA was a monumental discovery. 40 00:02:15,666 --> 00:02:17,600 It would have been hard for anyone, 41 00:02:17,633 --> 00:02:19,433 no matter how brilliant they were, 42 00:02:19,466 --> 00:02:22,300 to do another thing at that level. 43 00:02:22,333 --> 00:02:26,333 -It was even more important than Darwin. 44 00:02:26,366 --> 00:02:29,666 -There are many adjectives one could use 45 00:02:29,700 --> 00:02:32,133 to describe Jim Watson, and "humble" is probably not 46 00:02:32,166 --> 00:02:35,400 the first to jump to your lips. 47 00:02:35,433 --> 00:02:41,733 ## 48 00:02:41,766 --> 00:02:44,100 -He's kind of the enfant terrible. 49 00:02:44,133 --> 00:02:46,866 -Jim is a radical. 50 00:02:46,900 --> 00:02:48,500 -He's an anarchist. 51 00:02:48,533 --> 00:02:50,833 -Rules are there to be broken. 52 00:02:50,866 --> 00:02:52,000 He's not afraid of that. 53 00:02:52,033 --> 00:02:55,833 -The rebel against all standard thinking. 54 00:02:55,866 --> 00:02:58,600 -He was so innovative. He had such vision. 55 00:02:58,633 --> 00:03:02,566 And he was so full of intellectual energy and life. 56 00:03:02,600 --> 00:03:06,133 But he upset too many people. 57 00:03:07,766 --> 00:03:11,266 -You have gotten in trouble with what you say and what you write. 58 00:03:11,300 --> 00:03:12,700 -Incredibly caustic, 59 00:03:12,733 --> 00:03:14,800 irresponsible things about women, 60 00:03:14,833 --> 00:03:18,900 about African-Americans, about whole categories of people. 61 00:03:18,933 --> 00:03:20,533 -I don't know whether simply because you're the most 62 00:03:20,566 --> 00:03:22,200 candid person alive 63 00:03:22,233 --> 00:03:25,600 or whether you have no edit function in your brain. 64 00:03:25,633 --> 00:03:30,466 -We've all heard the racist, sexist, eugenicist, you name it. 65 00:03:30,500 --> 00:03:34,300 There's a risk to thinking about genes all the time. 66 00:03:37,300 --> 00:03:40,133 -He loves throwing ideas out there 67 00:03:40,166 --> 00:03:45,233 that provoke people to push back against them. 68 00:03:45,266 --> 00:03:49,700 -Sometimes telling the truth or just thinking the truth 69 00:03:49,733 --> 00:03:53,766 leads you into great difficulty, like, you know, Plato 70 00:03:53,800 --> 00:03:57,266 or, particularly, Galileo. 71 00:03:58,900 --> 00:04:01,266 They gave him life imprisonment. 72 00:04:03,433 --> 00:04:07,566 -There are, you know, two sides, 73 00:04:07,600 --> 00:04:11,866 and one you clearly can't understand, 74 00:04:11,900 --> 00:04:15,300 and the other embodies a person 75 00:04:15,333 --> 00:04:19,833 that you respect and interact with for how they engage science 76 00:04:19,866 --> 00:04:22,566 and how they think about a problem. 77 00:04:22,600 --> 00:04:25,100 And they can't be reconciled. 78 00:04:26,800 --> 00:04:28,933 -I think it's very hard to reconcile all the parts. 79 00:04:28,966 --> 00:04:32,033 I don't think they really fit together very well. 80 00:04:32,066 --> 00:04:35,333 And I think it's just part of the bundle of things 81 00:04:35,366 --> 00:04:39,666 that make up this complicated human being. 82 00:04:39,700 --> 00:04:41,566 -People are enigmas. 83 00:04:41,600 --> 00:04:42,900 We all are. 84 00:04:42,933 --> 00:04:44,733 Some of us are just bigger enigmas 85 00:04:44,766 --> 00:04:47,300 in more different directions than others. 86 00:04:47,333 --> 00:04:55,100 ## 87 00:04:55,133 --> 00:05:02,966 ## 88 00:05:03,000 --> 00:05:10,766 ## 89 00:05:10,800 --> 00:05:14,000 -I've had this prejudice since, you know, 90 00:05:14,033 --> 00:05:18,566 my 20s that genes really are important. 91 00:05:20,000 --> 00:05:22,966 Oh, I think I'm a real old-fashioned believer 92 00:05:23,000 --> 00:05:29,100 in the paramount role of genes as opposed to environment. 93 00:05:30,633 --> 00:05:34,266 Genes -- they make you what you are. 94 00:05:34,300 --> 00:05:39,000 ## 95 00:05:39,033 --> 00:05:42,966 I want to be known as both a writer and a scientist. 96 00:05:44,166 --> 00:05:47,666 I might even be a mathematician. 97 00:05:47,700 --> 00:05:49,500 Just some of my dreams. 98 00:05:53,933 --> 00:05:57,700 You know, I like to believe that I've been successful 99 00:05:57,733 --> 00:06:00,133 for some of the genes 100 00:06:00,166 --> 00:06:04,666 that I probably shared with my relative Orson Welles. 101 00:06:04,700 --> 00:06:08,300 -The DNA molecule might very well turn out to be 102 00:06:08,333 --> 00:06:09,800 the most important discovery 103 00:06:09,833 --> 00:06:12,566 in the whole history of medical science. 104 00:06:12,600 --> 00:06:16,966 Imagine the implications to duplicate a human being 105 00:06:17,000 --> 00:06:20,866 genetically down to the last detail. 106 00:06:20,900 --> 00:06:25,266 -"Citizen Kane" was sort of the most famous movie ever made, 107 00:06:25,300 --> 00:06:27,733 you know, so the double helix 108 00:06:27,766 --> 00:06:31,666 was the most famous piece of chemistry ever done. 109 00:06:31,700 --> 00:06:34,666 -Using physical and chemical clues, 110 00:06:34,700 --> 00:06:36,633 scientists have been able to figure out 111 00:06:36,666 --> 00:06:39,533 how the DNA molecule looks in detail. 112 00:06:39,566 --> 00:06:42,000 -Well, gee. What kind of stuff is DNA? 113 00:06:42,033 --> 00:06:43,433 -It's who you are. 114 00:06:43,466 --> 00:06:47,166 That very core of your being -- it's in your DNA. 115 00:06:47,200 --> 00:06:49,266 It's in your genes. 116 00:06:49,300 --> 00:06:52,333 If you're talking about the molecule of life, 117 00:06:52,366 --> 00:06:53,566 it has to be able to do 118 00:06:53,600 --> 00:06:55,333 an incredible number of things, right? 119 00:06:55,366 --> 00:06:57,733 It has to exist in every cell. 120 00:06:57,766 --> 00:07:01,600 It has to have enough diversity that, from that information, 121 00:07:01,633 --> 00:07:04,900 you can create an entire organism. 122 00:07:04,933 --> 00:07:09,166 And it also has to be able replicate itself. 123 00:07:09,200 --> 00:07:13,700 So, understanding the structure of the DNA molecule 124 00:07:13,733 --> 00:07:17,200 is really key to thinking about how all of these properties 125 00:07:17,233 --> 00:07:20,800 can exist in a single molecule. 126 00:07:20,833 --> 00:07:23,500 -DNA is often called a double helix. 127 00:07:23,533 --> 00:07:25,866 -It's two strands... 128 00:07:25,900 --> 00:07:28,566 -Kind of like a pair of spiral staircases. 129 00:07:28,600 --> 00:07:29,766 -...like a twisting ladder. 130 00:07:29,800 --> 00:07:32,266 -Those are DNA's backbones. 131 00:07:32,300 --> 00:07:35,333 There's no information, per se, in the backbone. 132 00:07:35,366 --> 00:07:38,566 What those backbones are supporting in between them... 133 00:07:38,600 --> 00:07:40,900 -The rungs of the ladder... -...that's what makes 134 00:07:40,933 --> 00:07:43,700 each of us genetically distinct. 135 00:07:43,733 --> 00:07:46,833 -The whole of nature's instructions are printed 136 00:07:46,866 --> 00:07:49,833 in these four chemical letters. 137 00:07:49,866 --> 00:07:51,900 -The rungs are called "bases," 138 00:07:51,933 --> 00:07:54,200 which are these little compounds... 139 00:07:54,233 --> 00:07:55,733 -There are four bases... 140 00:07:55,766 --> 00:07:58,200 -...adenine, cytosine, guanine, and thymine. 141 00:07:58,233 --> 00:07:59,766 -...A, C, G, and T. 142 00:07:59,800 --> 00:08:03,300 -And they bond together with hydrogen bonds. 143 00:08:03,333 --> 00:08:05,200 -A always pairs with T. 144 00:08:05,233 --> 00:08:07,133 C always pairs with G. 145 00:08:07,166 --> 00:08:09,333 -We have four different puzzle pieces 146 00:08:09,366 --> 00:08:12,133 that you can arrange in any number of ways. 147 00:08:12,166 --> 00:08:14,166 -If you change the sequence of bases, 148 00:08:14,200 --> 00:08:17,133 that can change the organism itself. 149 00:08:18,966 --> 00:08:23,000 If you take those two strands and you pull them apart, 150 00:08:23,033 --> 00:08:28,066 you can rebuild a new second strand on each one of those, 151 00:08:28,100 --> 00:08:30,666 and you will have two identical copies 152 00:08:30,700 --> 00:08:32,833 of the original DNA molecule. 153 00:08:32,866 --> 00:08:35,800 -That tells you how hereditary information 154 00:08:35,833 --> 00:08:38,866 is passed down to the next generation. 155 00:08:41,866 --> 00:08:45,033 That's the central insight of the double helix. 156 00:08:45,066 --> 00:08:53,366 ## 157 00:08:53,400 --> 00:08:58,166 -I was born in Chicago on April 6, 1928. 158 00:08:59,833 --> 00:09:03,933 I grew up on the South Side of Chicago 159 00:09:03,966 --> 00:09:07,366 in a clean, middle-class neighborhood. 160 00:09:09,133 --> 00:09:10,966 My mother was very social. 161 00:09:11,000 --> 00:09:13,000 She was a real social winner. 162 00:09:13,033 --> 00:09:14,400 Everyone liked her. 163 00:09:14,433 --> 00:09:16,466 She was unusually nice. 164 00:09:18,300 --> 00:09:23,566 My father was shy, whereas I've never been shy. 165 00:09:23,600 --> 00:09:25,100 You know, sometimes it's to the point 166 00:09:25,133 --> 00:09:28,900 of saying too much of the truth. 167 00:09:30,133 --> 00:09:31,433 My parents believed 168 00:09:31,466 --> 00:09:34,933 that you just had to look after other people. 169 00:09:34,966 --> 00:09:39,833 They saw the solution to many of our nation's problems 170 00:09:39,866 --> 00:09:42,300 should only be solved by the government 171 00:09:42,333 --> 00:09:45,766 as opposed to business. 172 00:09:45,800 --> 00:09:48,800 My father had been an amateur birdwatcher, 173 00:09:48,833 --> 00:09:50,966 a very obsessive one. 174 00:09:53,100 --> 00:09:54,766 Whenever there were birds around, 175 00:09:54,800 --> 00:09:56,966 we went out together and walked. 176 00:10:01,533 --> 00:10:06,066 -Jim went to the University of Chicago 177 00:10:06,100 --> 00:10:09,066 at age 16. 178 00:10:09,100 --> 00:10:13,666 He thought for a while he wanted to be an ornithologist. 179 00:10:13,700 --> 00:10:16,200 -I thought probably I'll be teaching birds 180 00:10:16,233 --> 00:10:18,166 in a school like Montana. 181 00:10:19,333 --> 00:10:22,766 I like Montana, so I wasn't in any sense dreading 182 00:10:22,800 --> 00:10:25,333 what my life was going to be. 183 00:10:25,366 --> 00:10:29,933 Suddenly, I just saw something else grip me more. 184 00:10:32,933 --> 00:10:35,300 -Schroedinger was a quantum physicist, 185 00:10:35,333 --> 00:10:39,700 and Schroedinger's book asked the question, 186 00:10:39,733 --> 00:10:42,133 "What is a gene?" 187 00:10:42,166 --> 00:10:44,466 -That was a really big thing. 188 00:10:44,500 --> 00:10:47,933 That was maybe the biggest of all questions. 189 00:10:47,966 --> 00:10:51,400 I read that in the spring of '46. 190 00:10:51,433 --> 00:10:53,300 And I remember I said "What Is Life?" 191 00:10:53,333 --> 00:10:56,300 was more interesting than bird migrations." 192 00:10:58,733 --> 00:11:02,300 -Schroedinger basically presented life 193 00:11:02,333 --> 00:11:04,066 as a question of physics. 194 00:11:07,833 --> 00:11:12,533 Physicists were very satisfied with themselves by the 1930s, 195 00:11:12,566 --> 00:11:14,400 and they had every right to be. 196 00:11:14,433 --> 00:11:20,066 They had discovered particles like electrons and protons. 197 00:11:20,100 --> 00:11:25,500 Physicists were able to unlock the energy inside of atoms 198 00:11:25,533 --> 00:11:28,633 that you could see in nuclear power and nuclear weapons. 199 00:11:31,100 --> 00:11:32,666 There were all these amazing things that 200 00:11:32,700 --> 00:11:34,300 were happening with quantum physics, 201 00:11:34,333 --> 00:11:35,966 and they really started to feel like they were starting 202 00:11:36,000 --> 00:11:40,666 to find most of the forces and the particles in the universe. 203 00:11:45,433 --> 00:11:47,700 And yet when they looked over at life... 204 00:11:49,533 --> 00:11:50,500 [ Baby crying ] 205 00:11:50,533 --> 00:11:51,666 ...they said, "Wait a minute. 206 00:11:51,700 --> 00:11:53,766 Like, we can't explain that." 207 00:11:53,800 --> 00:11:58,300 -This body -- what is it? How did it begin? 208 00:11:58,333 --> 00:12:04,166 -The discovery of DNA itself as the hereditary material 209 00:12:04,200 --> 00:12:08,700 was not the discovery of Watson and Crick. 210 00:12:08,733 --> 00:12:10,266 -About the time that Darwin published 211 00:12:10,300 --> 00:12:13,633 "On the Origin of the Species," a Swiss-German scientist 212 00:12:13,666 --> 00:12:17,933 named Friedrich Miescher was looking for a project, 213 00:12:17,966 --> 00:12:20,433 and his adviser said, 214 00:12:20,466 --> 00:12:23,000 "See if you can find out anything about the nucleus." 215 00:12:25,033 --> 00:12:27,966 Miescher went down to the local hospital 216 00:12:28,000 --> 00:12:35,200 and got some bandages from patients and scraped off the pus 217 00:12:35,233 --> 00:12:38,366 because that was a great source of white blood cells 218 00:12:38,400 --> 00:12:40,833 and each one of those has a nucleus. 219 00:12:40,866 --> 00:12:44,166 So he had a little vial of cell nuclei, ground them up, 220 00:12:44,200 --> 00:12:46,766 and did chemical tests on them. 221 00:12:46,800 --> 00:12:51,166 And he discovered in the cell nucleus this new material. 222 00:12:51,200 --> 00:12:53,333 He didn't know what it was. 223 00:12:53,366 --> 00:12:55,333 He discovered DNA. 224 00:12:55,366 --> 00:13:01,033 But DNA is not yet thought of as the material of genes. 225 00:13:01,066 --> 00:13:04,400 It's still pus on a bandage. 226 00:13:04,433 --> 00:13:07,233 We knew by about 1910 227 00:13:07,266 --> 00:13:11,133 that genes were associated with chromosomes. 228 00:13:11,166 --> 00:13:16,566 Chromosomes were known to be made of DNA and protein. 229 00:13:16,600 --> 00:13:21,466 It wasn't clear which one was the hereditary material. 230 00:13:21,500 --> 00:13:26,166 Protein is most of the interesting stuff 231 00:13:26,200 --> 00:13:28,666 that goes on in your body -- 232 00:13:28,700 --> 00:13:33,466 tissue, muscle, blood, sinew, organs. 233 00:13:33,500 --> 00:13:36,400 Around the turn of the century, 234 00:13:36,433 --> 00:13:39,466 a number of people studied the biochemistry of DNA, 235 00:13:39,500 --> 00:13:43,100 found out that it has these four subunits. 236 00:13:43,133 --> 00:13:48,333 Protein has 20 or more different building blocks. 237 00:13:48,366 --> 00:13:51,133 So, it seemed obvious that protein 238 00:13:51,166 --> 00:13:52,733 as a more complicated molecule, 239 00:13:52,766 --> 00:13:57,033 so, probably, it was the material of the gene. 240 00:13:57,066 --> 00:14:01,066 Then in 1944, out of left field 241 00:14:01,100 --> 00:14:04,700 came an experiment that changed the game. 242 00:14:07,433 --> 00:14:10,800 -Avery, MacLeod, and McCarty did an eloquent experiment 243 00:14:10,833 --> 00:14:12,633 with the bacterium pneumococcus. 244 00:14:12,666 --> 00:14:15,333 -The bacteria that caused pneumonia. 245 00:14:15,366 --> 00:14:18,266 There were different strains of the bacteria, 246 00:14:18,300 --> 00:14:20,433 and one of those strains was virulent, 247 00:14:20,466 --> 00:14:22,466 meaning it caused the disease. 248 00:14:22,500 --> 00:14:25,133 Then you had another form of the bacteria 249 00:14:25,166 --> 00:14:27,600 that was non-virulent. 250 00:14:27,633 --> 00:14:31,066 -Oswald Avery showed that you could convert 251 00:14:31,100 --> 00:14:34,200 the benign form into the virulent form 252 00:14:34,233 --> 00:14:37,833 when the only thing exchanged was DNA. 253 00:14:37,866 --> 00:14:41,000 -These bacteria -- when they divided, 254 00:14:41,033 --> 00:14:44,866 their descendants could be killers, too. 255 00:14:44,900 --> 00:14:47,866 -This, therefore, was definitive evidence 256 00:14:47,900 --> 00:14:51,366 that DNA was the molecule of heredity. 257 00:14:51,400 --> 00:14:55,300 -So, experiments like Avery's were making it clear 258 00:14:55,333 --> 00:15:01,266 that DNA was the stuff of genes, but that alone didn't tell you 259 00:15:01,300 --> 00:15:03,066 how they stored genetic information. 260 00:15:03,100 --> 00:15:05,400 They didn't even tell you what DNA looked like. 261 00:15:07,533 --> 00:15:10,066 -The Cavendish laboratory at Cambridge University 262 00:15:10,100 --> 00:15:14,366 was the most distinguished laboratory for physics 263 00:15:14,400 --> 00:15:16,500 in the world. 264 00:15:16,533 --> 00:15:18,166 That's where Watson went. 265 00:15:22,400 --> 00:15:26,666 -Francis Crick was a physicist who was turned biologist, 266 00:15:26,700 --> 00:15:31,833 and he just happened to be in the same office with Watson, 267 00:15:31,866 --> 00:15:36,200 and they struck up a conversation. 268 00:15:36,233 --> 00:15:40,866 -Francis was, you know, the most intelligent person I met. 269 00:15:40,900 --> 00:15:43,233 And Crick would have never focused on DNA 270 00:15:43,266 --> 00:15:45,533 if I hadn't been there. 271 00:15:45,566 --> 00:15:48,466 -Crick had done amazing work in World War II, 272 00:15:48,500 --> 00:15:52,200 working with the military on different kinds of technology. 273 00:15:52,233 --> 00:15:53,766 And so he was part of that generation 274 00:15:53,800 --> 00:15:58,033 that was trying to get their footing in the post-war world. 275 00:15:59,166 --> 00:16:02,466 -He was just this larger-than-life personality, 276 00:16:02,500 --> 00:16:07,833 and, I think, was a great foil to Jim 277 00:16:07,866 --> 00:16:10,800 in the sense that they played off each other, 278 00:16:10,833 --> 00:16:15,033 but they understood each other at the same time, immediately. 279 00:16:15,066 --> 00:16:17,500 It was like they could finish each other's sentences, I think. 280 00:16:17,533 --> 00:16:20,833 -We liked each other. 281 00:16:20,866 --> 00:16:22,400 Yeah. 282 00:16:22,433 --> 00:16:25,900 You know, I didn't adore him or anything like that, but, uh... 283 00:16:28,166 --> 00:16:30,400 I couldn't get enough of him. 284 00:16:32,533 --> 00:16:35,333 -Their relationship was driven by mutual competition. 285 00:16:35,366 --> 00:16:37,333 They were always competing against each other. 286 00:16:37,366 --> 00:16:39,900 And that was part of what made them close friends. 287 00:16:39,933 --> 00:16:43,866 That was part of what made them push so hard 288 00:16:43,900 --> 00:16:45,866 to get that structure. 289 00:16:50,700 --> 00:16:53,500 -Sometimes when you see two names linked together, 290 00:16:53,533 --> 00:16:56,966 you know that one person did all the work. 291 00:16:59,066 --> 00:17:02,533 But I think Watson and Crick was -- you know, we were equal. 292 00:17:06,400 --> 00:17:07,866 -In the late 1960s, 293 00:17:07,900 --> 00:17:11,766 Watson decides that he wants to tell his own personal story 294 00:17:11,800 --> 00:17:15,033 about discovering the structure of DNA in 1953. 295 00:17:15,066 --> 00:17:16,333 -I mean, it was a great story. 296 00:17:16,366 --> 00:17:18,666 It would be nice if we could write it up. 297 00:17:18,700 --> 00:17:21,433 I was relieved when Francis had no intention 298 00:17:21,466 --> 00:17:24,433 of getting involved in it. 299 00:17:24,466 --> 00:17:27,866 And I guess you have to say it was a chance 300 00:17:27,900 --> 00:17:32,100 to really show I was, in some way... 301 00:17:32,133 --> 00:17:34,333 better than Francis. 302 00:17:34,366 --> 00:17:37,466 -"The Double Helix" is kind of a prototype 303 00:17:37,500 --> 00:17:41,766 of telling the story of how science really works, 304 00:17:41,800 --> 00:17:44,566 which was extremely controversial at the time. 305 00:17:44,600 --> 00:17:50,600 ## 306 00:17:50,633 --> 00:17:55,233 -Here was an account that was actually exciting to read. 307 00:17:55,266 --> 00:17:57,733 With characters and competitions and stories 308 00:17:57,766 --> 00:17:59,766 and bad guys and good guys. 309 00:17:59,800 --> 00:18:01,333 -There's a tremendous amount of science 310 00:18:01,366 --> 00:18:06,733 packed into those 107 pages, but he tells the science story 311 00:18:06,766 --> 00:18:11,233 by talking about what was driving the people. 312 00:18:11,266 --> 00:18:14,733 -Science was usually portrayed in a very gentlemanly way. 313 00:18:14,766 --> 00:18:16,466 You were polite to your colleagues. 314 00:18:16,500 --> 00:18:17,900 You did not badmouth them. 315 00:18:17,933 --> 00:18:21,600 You never said that their ideas were screwy. 316 00:18:21,633 --> 00:18:23,933 Watson said, "It's not gentlemanly. 317 00:18:23,966 --> 00:18:27,166 It's rowdy, and it's fun, and it's rude." 318 00:18:29,533 --> 00:18:31,533 -Generally, as soon as I finished a chapter, 319 00:18:31,566 --> 00:18:34,600 I would always show it to someone -- generally, a girl. 320 00:18:36,600 --> 00:18:39,166 -One day he had something he wanted to show me, 321 00:18:39,200 --> 00:18:41,633 and it was a draft of "The Double Helix." 322 00:18:41,666 --> 00:18:44,200 And he couldn't resist looking to see what the reaction 323 00:18:44,233 --> 00:18:46,766 was gonna be to these pretty outrageous -- 324 00:18:46,800 --> 00:18:49,366 some of the outrageous things he said. 325 00:18:49,400 --> 00:18:50,766 I thought, "Wow, this is 326 00:18:50,800 --> 00:18:52,133 the best science book I've ever read," you know? 327 00:18:52,166 --> 00:18:55,600 I just thought it was just thrilling. 328 00:18:55,633 --> 00:18:59,633 -"I have never seen Francis Crick in a modest mood." 329 00:19:00,700 --> 00:19:02,866 The first sentence, I, you know, 330 00:19:02,900 --> 00:19:05,300 would say that was the essence of the book. 331 00:19:05,333 --> 00:19:08,466 When I had the first sentence, I had a point of view. 332 00:19:11,200 --> 00:19:13,100 -Rather than thinking of it as you're looking 333 00:19:13,133 --> 00:19:17,600 through transparent glass window into 1952-53, 334 00:19:17,633 --> 00:19:19,566 "this is the way it was," 335 00:19:19,600 --> 00:19:22,566 think of it as looking through glass darkly, 336 00:19:22,600 --> 00:19:24,333 through a distorting lens. 337 00:19:24,366 --> 00:19:28,833 You can't think of it as a direct look into the past. 338 00:19:30,566 --> 00:19:32,633 -In many ways, "The Double Helix" 339 00:19:32,666 --> 00:19:35,800 is a nonfiction novel. 340 00:19:35,833 --> 00:19:39,033 It tells a basically true story, 341 00:19:39,066 --> 00:19:41,933 but it fictionalizes the characters, 342 00:19:41,966 --> 00:19:43,766 including Watson himself. 343 00:19:48,366 --> 00:19:52,800 -The outsider comes in, shakes everybody up, 344 00:19:52,833 --> 00:19:55,200 and just shows them how it's done. 345 00:19:57,733 --> 00:20:00,033 -I think Francis Crick, the brilliant loudmouth 346 00:20:00,066 --> 00:20:01,500 who spends more time 347 00:20:01,533 --> 00:20:04,466 solving other people's problems than doing his own. 348 00:20:04,500 --> 00:20:07,666 -He dominated any room he was in. 349 00:20:08,966 --> 00:20:12,233 -Maurice Wilkins, a researcher at King's College, 350 00:20:12,266 --> 00:20:13,900 was trying to use X-rays 351 00:20:13,933 --> 00:20:16,700 to figure out the structure of DNA. 352 00:20:19,966 --> 00:20:23,766 He was very reserved, very, very, very British. 353 00:20:23,800 --> 00:20:27,100 -Dr. Maurice Wilkins lives with his family in Blackheath 354 00:20:27,133 --> 00:20:28,733 in South London. 355 00:20:28,766 --> 00:20:30,733 Dr. Wilkins, what do you actually do? 356 00:20:30,766 --> 00:20:33,900 -The main thing in my kind of scientific work 357 00:20:33,933 --> 00:20:36,300 is to be able to fiddle with a thing, 358 00:20:36,333 --> 00:20:38,266 go on fiddling with it, and fiddle, fiddle. 359 00:20:38,300 --> 00:20:40,966 -He's the kind of person that you think 360 00:20:41,000 --> 00:20:45,333 would have been dabbling around with this forever. 361 00:20:45,366 --> 00:20:48,033 -DNA belonged to Wilkins, even though he wasn't 362 00:20:48,066 --> 00:20:51,333 necessarily making any progress on it. 363 00:20:51,366 --> 00:20:54,500 -Maurice Wilkins was not very effective, you know? 364 00:20:54,533 --> 00:20:57,633 He doesn't come out... 365 00:20:57,666 --> 00:20:59,800 good in the story. 366 00:20:59,833 --> 00:21:03,733 -At the time, Maurice was working under a man 367 00:21:03,766 --> 00:21:05,233 called Randall. 368 00:21:05,266 --> 00:21:07,733 -John Randall, the head of the lab... 369 00:21:07,766 --> 00:21:13,400 -Randall took the project away from Maurice Wilkins. 370 00:21:13,433 --> 00:21:15,966 -The decision was to bring in Rosalind Franklin 371 00:21:16,000 --> 00:21:21,600 to work on his project with his student on his DNA. 372 00:21:21,633 --> 00:21:25,833 -Rosalind Franklin, in her 20s, became a real master 373 00:21:25,866 --> 00:21:28,666 of X-ray crystallography -- to use X-rays 374 00:21:28,700 --> 00:21:32,666 to figure out the structures of complicated molecules. 375 00:21:32,700 --> 00:21:34,100 Franklin was not a biologist, 376 00:21:34,133 --> 00:21:38,466 and she was very frank about that. 377 00:21:38,500 --> 00:21:42,766 She did a lot of work for years on coal, 378 00:21:42,800 --> 00:21:45,133 so she was actually able to figure out 379 00:21:45,166 --> 00:21:47,833 the very complicated structure of coal. 380 00:21:49,133 --> 00:21:52,566 Franklin got hired with the understanding 381 00:21:52,600 --> 00:21:57,466 that she would be studying the structure of DNA. 382 00:21:57,500 --> 00:22:00,600 Well, nobody told Wilkins. 383 00:22:00,633 --> 00:22:02,100 [ Laughs ] 384 00:22:02,133 --> 00:22:05,100 And nobody told Franklin 385 00:22:05,133 --> 00:22:08,233 that Wilkins was already studying DNA. 386 00:22:08,266 --> 00:22:13,433 -I mean, that was unbelievable that that happened. 387 00:22:13,466 --> 00:22:19,333 -He starts to treat her as if, like, she's his assistant, 388 00:22:19,366 --> 00:22:22,366 and Rosalind Franklin was not the sort of person 389 00:22:22,400 --> 00:22:24,433 to be treated as an assistant. 390 00:22:25,766 --> 00:22:30,100 She was very tough and wasn't gonna take guff from anybody. 391 00:22:32,100 --> 00:22:35,300 And Wilkins clearly did not know how to deal with a strong woman. 392 00:22:35,333 --> 00:22:37,266 -In "The Double Helix," she's represented 393 00:22:37,300 --> 00:22:40,900 in almost an entirely negative light. 394 00:22:42,333 --> 00:22:45,766 Like, if this were a fairy tale, she might be some kind 395 00:22:45,800 --> 00:22:48,300 of a witch who is holding on to the treasure 396 00:22:48,333 --> 00:22:50,233 and she won't let it go. 397 00:22:50,266 --> 00:22:52,633 -Throughout the book, he uses the name "Rosy" 398 00:22:52,666 --> 00:22:55,766 to refer to Rosalind Franklin. 399 00:22:55,800 --> 00:22:59,266 In her own biographies, it is made very clear 400 00:22:59,300 --> 00:23:02,366 that she found that name an insult. 401 00:23:02,400 --> 00:23:03,733 -He said if she had wanted to, 402 00:23:03,766 --> 00:23:07,133 she could have looked really pretty, as though, 403 00:23:07,166 --> 00:23:09,533 number one, she should have, and, number two, she didn't, 404 00:23:09,566 --> 00:23:12,233 and, number three, if she really put effort into it, 405 00:23:12,266 --> 00:23:14,400 that's the thing that's really important. 406 00:23:17,400 --> 00:23:20,300 -Outside the Franklin that Watson knew, 407 00:23:20,333 --> 00:23:24,233 if you followed her to one of her weekends in Paris, 408 00:23:24,266 --> 00:23:26,666 you would see a very, very different woman. 409 00:23:30,633 --> 00:23:33,033 -The book was controversial because of the way 410 00:23:33,066 --> 00:23:35,033 Jim wrote about people. 411 00:23:35,066 --> 00:23:36,933 There are a lot of passages in the book 412 00:23:36,966 --> 00:23:38,833 that are just insulting. 413 00:23:38,866 --> 00:23:44,100 ## 414 00:23:44,133 --> 00:23:47,533 He could have written a book about his personal experiences 415 00:23:47,566 --> 00:23:49,733 in the discovery of the structure of DNA 416 00:23:49,766 --> 00:23:52,300 without doing that to people that he worked with. 417 00:23:52,333 --> 00:23:55,333 -I knew people would say, "You can't tell. 418 00:23:55,366 --> 00:23:57,233 It'll upset people." 419 00:23:57,266 --> 00:23:59,400 Finally, it upset Francis. 420 00:23:59,433 --> 00:24:03,566 Then he objected to the president of Harvard. 421 00:24:04,566 --> 00:24:07,233 -It was getting published by Harvard University Press, 422 00:24:07,266 --> 00:24:09,433 and they wouldn't publish it, 423 00:24:09,466 --> 00:24:11,566 partly because they were getting communications 424 00:24:11,600 --> 00:24:15,066 from Crick and Wilkins saying, "Don't do this." 425 00:24:18,400 --> 00:24:21,433 -Francis wrote a letter to the president of Harvard 426 00:24:21,466 --> 00:24:23,866 or told the head of the press, 427 00:24:23,900 --> 00:24:27,600 "I don't want to get between two wild men." 428 00:24:27,633 --> 00:24:29,566 -Francis Crick wouldn't talk to him for years 429 00:24:29,600 --> 00:24:31,233 after that came out. 430 00:24:33,400 --> 00:24:34,933 But it was a best seller. 431 00:24:37,000 --> 00:24:39,133 -It's on the list of top 100 books 432 00:24:39,166 --> 00:24:41,800 in the American history of literature. 433 00:24:41,833 --> 00:24:47,233 -And every history of DNA since then starts with Watson's book. 434 00:24:52,033 --> 00:24:56,833 -Well, it takes all kinds of scientists to make science. 435 00:24:56,866 --> 00:25:00,766 -Most scientists work in a laboratory. 436 00:25:00,800 --> 00:25:02,000 It's like cooking. 437 00:25:02,033 --> 00:25:03,466 You know, you're following recipes, 438 00:25:03,500 --> 00:25:06,133 and you're doing experiments, and you get results, 439 00:25:06,166 --> 00:25:10,933 and you look at the results, and that changes your thinking. 440 00:25:10,966 --> 00:25:14,200 Jim, on the other hand, used the results of everybody else. 441 00:25:14,233 --> 00:25:17,033 -I was never really a lab person. 442 00:25:19,833 --> 00:25:23,800 Francis said I was always off working with my hands, 443 00:25:23,833 --> 00:25:25,400 and I suspect I am. 444 00:25:25,433 --> 00:25:29,333 I like to think about other people's data. 445 00:25:30,133 --> 00:25:33,700 I found that there's actually a role for people 446 00:25:33,733 --> 00:25:37,566 who just think about other people's data. 447 00:25:37,600 --> 00:25:41,100 -"Impresario" is actually a great word for Jim. 448 00:25:41,133 --> 00:25:44,733 -He created a vibrant department of molecular biology at Harvard. 449 00:25:44,766 --> 00:25:46,766 -He liked having people in his lab 450 00:25:46,800 --> 00:25:50,066 whom he could shape and mold. 451 00:25:50,100 --> 00:25:53,933 -It was a bunch of rag-tag, kind of offbeat characters 452 00:25:53,966 --> 00:25:56,800 who came together to make the science. 453 00:25:56,833 --> 00:25:59,233 -It was the beginning of molecular biology, 454 00:25:59,266 --> 00:26:02,533 and it was a time when nobody had been trained. 455 00:26:02,566 --> 00:26:06,533 We were the first people to be trained as molecular biologists. 456 00:26:08,500 --> 00:26:12,566 -You knew when you heard him that you were 457 00:26:12,600 --> 00:26:16,566 at the start of a revolution in understanding, 458 00:26:16,600 --> 00:26:20,666 and you felt as if you were part of this tiny group of people 459 00:26:20,700 --> 00:26:22,633 who had seen the light. 460 00:26:24,633 --> 00:26:28,133 [ Bell tolling ] 461 00:26:28,166 --> 00:26:30,500 -Until DNA came along, 462 00:26:30,533 --> 00:26:34,666 the big idea in biology was evolution. 463 00:26:34,700 --> 00:26:36,700 What was the tree of life? 464 00:26:36,733 --> 00:26:40,200 How did it branch and so on? 465 00:26:40,233 --> 00:26:43,400 -He wanted to displace these evolutionary biologists 466 00:26:43,433 --> 00:26:45,866 and replace them with molecular biologists, 467 00:26:45,900 --> 00:26:48,333 so he was going into war. 468 00:26:48,366 --> 00:26:51,800 -Basically, evolution was the top dog, 469 00:26:51,833 --> 00:26:55,566 and I went there and said, "I'm the top dog." 470 00:26:55,600 --> 00:27:00,166 DNA was more important than evolution. 471 00:27:00,200 --> 00:27:03,600 -He didn't care, I guess, if people disliked him. 472 00:27:03,633 --> 00:27:06,766 He didn't care because he knew he was right. 473 00:27:06,800 --> 00:27:09,600 If he had to upset somebody to do it, well, so what? 474 00:27:09,633 --> 00:27:10,833 That didn't bother him at all. 475 00:27:10,866 --> 00:27:14,600 In fact, he kind of got a kick out of it. 476 00:27:14,633 --> 00:27:15,966 -You can't go through life 477 00:27:16,000 --> 00:27:19,233 not making enemies and accomplish great things. 478 00:27:19,266 --> 00:27:21,600 You have to have the courage that something is better 479 00:27:21,633 --> 00:27:23,266 than something else. 480 00:27:26,200 --> 00:27:30,033 -When it was time to decide which lab I should work in 481 00:27:30,066 --> 00:27:33,766 to do my thesis work, I actually went along to 482 00:27:33,800 --> 00:27:37,300 a very famous professor at Harvard 483 00:27:37,333 --> 00:27:40,200 and asked whether I could work in his lab, 484 00:27:40,233 --> 00:27:43,266 and he looked at me and said, "But you're a woman. 485 00:27:43,300 --> 00:27:45,333 You'll get married. You'll have kids. 486 00:27:45,366 --> 00:27:46,966 What will be the good of your having done 487 00:27:47,000 --> 00:27:48,800 a science degree then?" 488 00:27:48,833 --> 00:27:52,033 And I made it out of his office before I burst into tears, 489 00:27:52,066 --> 00:27:56,200 and I went to my second thesis adviser choice. 490 00:27:56,233 --> 00:27:59,766 -Joan came and said, "Can I work for you?" 491 00:27:59,800 --> 00:28:03,266 And, uh, of course I said yes. 492 00:28:03,300 --> 00:28:06,633 -And it wasn't until several months later that I realized 493 00:28:06,666 --> 00:28:09,366 I was the first woman to whom he had ever said, 494 00:28:09,400 --> 00:28:12,466 yes, I could come be a graduate student in his lab. 495 00:28:13,866 --> 00:28:16,800 -I myself wondered, "Can women be scientists? 496 00:28:16,833 --> 00:28:18,233 There don't seem to be many." 497 00:28:18,266 --> 00:28:20,766 All these people winning the Nobel Prize were men. 498 00:28:20,800 --> 00:28:22,633 And I think one of the things that was so wonderful 499 00:28:22,666 --> 00:28:25,766 about Jim's support for a young person -- 500 00:28:25,800 --> 00:28:27,100 it didn't cross my mind -- 501 00:28:27,133 --> 00:28:28,600 he never made me feel, "Oh, you're a woman, 502 00:28:28,633 --> 00:28:29,833 and I don't know if you can do this." 503 00:28:29,866 --> 00:28:31,200 He never made me feel that. 504 00:28:31,233 --> 00:28:32,966 If he was interested in you, if he believed in you, 505 00:28:33,000 --> 00:28:36,733 if he thought you could do it, then he supported you. 506 00:28:38,566 --> 00:28:42,933 -I always found women made labs more interesting. 507 00:28:42,966 --> 00:28:46,133 I wanted as many women as possible, 508 00:28:46,166 --> 00:28:49,166 you know, as long as they were highly intelligent. 509 00:28:51,100 --> 00:28:53,500 -He confesses to have a penchant for pretty girls, 510 00:28:53,533 --> 00:28:56,000 and he doesn't -- 511 00:28:56,033 --> 00:28:59,200 he'll say it to anybody, and he certainly said it to me, 512 00:28:59,233 --> 00:29:01,433 you know, many, many, many times. 513 00:29:03,600 --> 00:29:04,933 -I think one forgets 514 00:29:04,966 --> 00:29:08,266 that this man was only 35 years old when I met him. 515 00:29:09,800 --> 00:29:12,200 For people of that age, whether they're men or women, 516 00:29:12,233 --> 00:29:14,866 sex is certainly on people's minds. 517 00:29:14,900 --> 00:29:18,000 -I knew I was gonna be very famous, 518 00:29:18,033 --> 00:29:22,300 but it didn't necessarily mean I'd ever get a girlfriend, 519 00:29:22,333 --> 00:29:26,266 and if you're an unmarried young man, 520 00:29:26,300 --> 00:29:27,766 that's what you think about. 521 00:29:27,800 --> 00:29:28,966 You want a girlfriend. 522 00:29:29,000 --> 00:29:36,833 ## 523 00:29:36,866 --> 00:29:40,166 -I worked for him in his office. 524 00:29:40,200 --> 00:29:43,433 I was actually a math major at that time. 525 00:29:43,466 --> 00:29:46,400 I started in my sophomore year. 526 00:29:46,433 --> 00:29:50,500 I had just turned 18 that summer. 527 00:29:51,233 --> 00:29:54,566 There must have been something really deep down that 528 00:29:54,600 --> 00:30:00,000 I couldn't have described that made me like him. 529 00:30:00,033 --> 00:30:03,533 So, I made a mental note at the end of the job interview 530 00:30:03,566 --> 00:30:05,500 that I would marry him. 531 00:30:06,433 --> 00:30:10,366 -We had one date at the end of summer, 532 00:30:10,400 --> 00:30:14,966 and then I took her to a sort of faculty party. 533 00:30:16,800 --> 00:30:18,366 Ask her. 534 00:30:18,400 --> 00:30:21,600 -At the end of the year, he took me to a cocktail party, 535 00:30:21,633 --> 00:30:23,866 and -- I don't know -- I had gin and tonics. 536 00:30:23,900 --> 00:30:25,866 And then he walked me back to the dorm, 537 00:30:25,900 --> 00:30:29,066 and I said, "Dr. Watson, it was really fun 538 00:30:29,100 --> 00:30:31,966 working for you this year," and then he said to me, 539 00:30:32,000 --> 00:30:36,066 "Well, I hope you'll work for me next year, too." 540 00:30:36,100 --> 00:30:41,233 So, that way, I knew he liked me. 541 00:30:41,266 --> 00:30:45,733 But he didn't really know how much I liked him. 542 00:30:45,766 --> 00:30:46,933 -You know, I didn't have 543 00:30:46,966 --> 00:30:49,833 a series of 20 important girlfriends. 544 00:30:49,866 --> 00:30:52,800 I didn't have any important girlfriend ever. 545 00:30:52,833 --> 00:30:57,866 And really never was with girls very much until I married Liz. 546 00:31:00,200 --> 00:31:03,533 -People knew that he was looking for a wife, I think. 547 00:31:03,566 --> 00:31:07,800 But we never saw any evidence of a girlfriend. 548 00:31:07,833 --> 00:31:11,833 -It wasn't a very public romance. 549 00:31:11,866 --> 00:31:16,133 -She was just 18, and I was then 38. 550 00:31:16,166 --> 00:31:19,200 -So I think -- I don't just think it. 551 00:31:19,233 --> 00:31:20,666 I've heard Jim say it. 552 00:31:20,700 --> 00:31:22,500 It was unseemly. 553 00:31:22,533 --> 00:31:28,766 Our dates my junior year consisted of a movie, 554 00:31:28,800 --> 00:31:32,066 a concert, a cocktail party or two, 555 00:31:32,100 --> 00:31:34,033 and sharing the same bed. 556 00:31:34,066 --> 00:31:36,100 [ Laughs ] 557 00:31:36,133 --> 00:31:38,000 That's about it. 558 00:31:38,033 --> 00:31:39,766 -[ Grunts ] 559 00:31:39,800 --> 00:31:41,233 [ Grunts ] 560 00:31:44,266 --> 00:31:46,533 Oh! 561 00:31:46,566 --> 00:31:47,933 I'm too slow. 562 00:31:47,966 --> 00:31:49,200 -Yeah, you got to go for the winner. 563 00:31:49,233 --> 00:31:52,200 That's what Dr. Watson likes to do. 564 00:31:52,233 --> 00:31:54,900 -You have to go for winners in science, too, you know? 565 00:31:54,933 --> 00:31:56,866 [ Chuckles ] 566 00:31:56,900 --> 00:32:02,100 ## 567 00:32:02,133 --> 00:32:07,300 ## 568 00:32:07,333 --> 00:32:10,233 -Linus Pauling was this great chemist. 569 00:32:10,266 --> 00:32:12,666 Jim saw him as the competition. 570 00:32:17,433 --> 00:32:20,766 -In a sense, when you're working on the same problem 571 00:32:20,800 --> 00:32:25,400 as someone else, you're at war with each other. 572 00:32:25,433 --> 00:32:27,600 -Why did he want to find out the structure of DNA? 573 00:32:27,633 --> 00:32:29,766 Is it to help humankind? 574 00:32:29,800 --> 00:32:31,866 Is it to advance human knowledge? 575 00:32:31,900 --> 00:32:33,933 No, it's 'cause he wanted to get it first. 576 00:32:33,966 --> 00:32:37,000 He wanted to beat Pauling. 577 00:32:37,033 --> 00:32:39,566 -Linus Pauling, by the early 1950s, 578 00:32:39,600 --> 00:32:41,300 had already established himself 579 00:32:41,333 --> 00:32:44,500 as perhaps the finest chemist in the world. 580 00:32:44,533 --> 00:32:47,833 -If we want to understand the human body, 581 00:32:47,866 --> 00:32:50,266 we must know its structure. 582 00:32:50,300 --> 00:32:52,466 -I guess both of us at that time -- 583 00:32:52,500 --> 00:32:54,333 our thoughts were dominated by Linus Pauling, 584 00:32:54,366 --> 00:32:58,333 a great chemist who was going to solve biology, and -- 585 00:32:58,366 --> 00:33:00,233 -Had you met Linus by this time? 586 00:33:00,266 --> 00:33:03,266 -He smiled at me. -He smiled at you once? 587 00:33:07,033 --> 00:33:08,933 -The story to me was the race with Pauling. 588 00:33:08,966 --> 00:33:11,833 Who was gonna win the race with Pauling? 589 00:33:11,866 --> 00:33:17,000 -In "The Double Helix," Linus Pauling is Goliath... 590 00:33:17,033 --> 00:33:18,966 the lion in the room. 591 00:33:19,000 --> 00:33:22,266 [ Applause ] 592 00:33:22,300 --> 00:33:24,866 The dark-horse team of Watson and Crick 593 00:33:24,900 --> 00:33:28,133 are going to try to bring down the giant. 594 00:33:28,166 --> 00:33:31,533 Pauling didn't know that he was racing against this guy. 595 00:33:31,566 --> 00:33:34,000 He probably didn't even know who Jim was. 596 00:33:34,033 --> 00:33:35,366 -Well, one day, 597 00:33:35,400 --> 00:33:38,600 Watson gets the news that he never wanted to hear. 598 00:33:38,633 --> 00:33:42,400 Linus Pauling had proposed a structure for DNA. 599 00:33:42,433 --> 00:33:45,366 -Of course, we were upset. -We were really on tenterhooks. 600 00:33:45,400 --> 00:33:48,533 -The question was, could it be right? 601 00:33:48,566 --> 00:33:52,766 -Pauling was claiming that it had three backbones. 602 00:33:52,800 --> 00:33:55,066 -A triple helix. 603 00:33:55,100 --> 00:33:57,600 -Three backbones -- that's wrong. 604 00:33:57,633 --> 00:34:00,733 -The structure was so awful. 605 00:34:00,766 --> 00:34:03,100 It was chemically impossible. 606 00:34:03,133 --> 00:34:04,433 [ Laughs ] 607 00:34:05,800 --> 00:34:07,633 -Very embarrassing for the great Linus Pauling 608 00:34:07,666 --> 00:34:09,266 to make a rookie error, 609 00:34:09,300 --> 00:34:13,100 and so Watson thought as soon as everybody starts pointing out 610 00:34:13,133 --> 00:34:16,000 to Pauling what a dumb mistake he made, 611 00:34:16,033 --> 00:34:20,966 he would just go at the DNA problem with everything he had 612 00:34:21,000 --> 00:34:23,066 and then he would crack it 'cause he's Linus Pauling. 613 00:34:23,100 --> 00:34:24,933 -The way Watson tells it, 614 00:34:24,966 --> 00:34:28,366 he had been down to King's College London 615 00:34:28,400 --> 00:34:31,400 to tell Franklin and Wilkins, 616 00:34:31,433 --> 00:34:34,966 "Look, the great Linus Pauling got it wrong!" 617 00:34:35,000 --> 00:34:36,500 -Linus wasn't gonna wait. 618 00:34:36,533 --> 00:34:39,533 Someone at Caltech was bound to tell Linus he was wrong. 619 00:34:39,566 --> 00:34:45,666 -He had seen Franklin's lab door open and gone in. 620 00:34:45,700 --> 00:34:52,133 ## 621 00:34:52,166 --> 00:34:54,166 Franklin didn't like that. 622 00:34:54,200 --> 00:34:59,166 She was very private, and Watson kind of barged in on her. 623 00:35:01,666 --> 00:35:03,566 She didn't like the interruption. 624 00:35:08,133 --> 00:35:12,133 And the way he tells it, he got a little cocky. 625 00:35:12,166 --> 00:35:19,033 ## 626 00:35:19,066 --> 00:35:21,000 Franklin just blew up at him. 627 00:35:21,033 --> 00:35:24,666 -She came toward me, and I thought she was going to hit me. 628 00:35:24,700 --> 00:35:27,300 I quickly got out, at which point Maurice was coming around, 629 00:35:27,333 --> 00:35:29,000 and she almost hit Maurice. 630 00:35:30,766 --> 00:35:33,533 -Oh, God. Who hit who? 631 00:35:33,566 --> 00:35:36,000 I don't think anybody hit anybody, actually. 632 00:35:36,033 --> 00:35:39,266 Some people may have thought someone was gonna hit somebody. 633 00:35:39,300 --> 00:35:42,500 -Wilkins and Watkins were decompressing after that, 634 00:35:42,533 --> 00:35:44,500 both sort of panting and sweating, 635 00:35:44,533 --> 00:35:48,000 and Wilkins said, "By the way, I got something to show you." 636 00:35:48,033 --> 00:35:53,466 ## 637 00:35:53,500 --> 00:35:55,533 -Maurice opened a drawer and took out a photograph, 638 00:35:55,566 --> 00:35:57,466 and, boy, I could hardly believe it. 639 00:35:59,500 --> 00:36:02,633 -Photograph 51 is quite extraordinary. 640 00:36:02,666 --> 00:36:06,800 -This was the best X-ray photograph of DNA ever taken. 641 00:36:06,833 --> 00:36:09,333 Wilkins couldn't take X-ray pictures that good. 642 00:36:09,366 --> 00:36:10,933 He knew that. 643 00:36:10,966 --> 00:36:15,533 -Franklin was probably the only person in the world good enough 644 00:36:15,566 --> 00:36:19,133 at what she did to take those pictures. 645 00:36:19,166 --> 00:36:22,066 -Raymond Gosling, who had worked with Franklin 646 00:36:22,100 --> 00:36:26,566 in creating the picture, gave Wilkins that photograph. 647 00:36:29,033 --> 00:36:30,266 -An X-ray picture is not 648 00:36:30,300 --> 00:36:32,566 a simple picture like a photograph. 649 00:36:32,600 --> 00:36:36,733 -You can't interpret it just by looking at it. 650 00:36:36,766 --> 00:36:40,166 -When a X-ray strikes the molecule, 651 00:36:40,200 --> 00:36:42,366 the waves of the X-rays can squeeze 652 00:36:42,400 --> 00:36:45,033 in between the atoms, and when they come out 653 00:36:45,066 --> 00:36:48,100 the other side, their directions are deviated. 654 00:36:51,533 --> 00:36:54,366 -What it is is the pattern of X-rays 655 00:36:54,400 --> 00:36:56,600 bouncing off the molecules. 656 00:36:59,433 --> 00:37:01,766 -You could tell there were these two strands of DNA 657 00:37:01,800 --> 00:37:04,033 that are wound around each other. 658 00:37:04,066 --> 00:37:06,933 That's what you can get from X-ray crystallography. 659 00:37:06,966 --> 00:37:08,666 What you can't get 660 00:37:08,700 --> 00:37:13,366 is what's the chemistry that's driving that structure. 661 00:37:16,533 --> 00:37:19,666 -Watson just sort of, like, looked at Photograph 51 662 00:37:19,700 --> 00:37:22,700 and got an idea of the structure that could explain it 663 00:37:22,733 --> 00:37:25,233 and then went off and built a model. 664 00:37:25,266 --> 00:37:29,266 -Watson and Crick built models. That was their approach. 665 00:37:29,300 --> 00:37:30,833 -I cut some things out of cardboard, 666 00:37:30,866 --> 00:37:32,433 and so made the right shapes 667 00:37:32,466 --> 00:37:35,566 and pasted things on which would indicate hydrogen atoms. 668 00:37:39,066 --> 00:37:41,933 -There's a lot of audacity in saying, 669 00:37:41,966 --> 00:37:45,866 "This can be figured out just by making models of it." 670 00:37:47,066 --> 00:37:48,133 -It was theory, you know, 671 00:37:48,166 --> 00:37:50,233 what might this molecule be like? 672 00:37:50,266 --> 00:37:52,100 What kind of structure might work? 673 00:37:52,133 --> 00:37:54,000 What would be plausible? 674 00:37:55,666 --> 00:37:58,533 -It's a hugely high-risk, low-probability 675 00:37:58,566 --> 00:38:01,466 approach to science. 676 00:38:01,500 --> 00:38:05,033 -And Franklin just thought this was ridiculous. 677 00:38:05,066 --> 00:38:06,900 -It's as if they were moving towards the problem 678 00:38:06,933 --> 00:38:08,666 from different directions. 679 00:38:08,700 --> 00:38:12,266 -She felt that the data had to speak for itself. 680 00:38:12,300 --> 00:38:16,266 She wanted to continue making excellent measurements. 681 00:38:16,300 --> 00:38:18,100 -Picture after picture after picture after picture, 682 00:38:18,133 --> 00:38:20,133 and then you sit down and then you think about it 683 00:38:20,166 --> 00:38:23,300 and then you work out an idea for the structure. 684 00:38:23,333 --> 00:38:25,100 She herself was getting pretty close 685 00:38:25,133 --> 00:38:27,333 to figuring out the structure of DNA. 686 00:38:27,366 --> 00:38:30,900 -But she's not gonna publish anything until, like, 687 00:38:30,933 --> 00:38:32,933 it's ready to take it to the bank. 688 00:38:32,966 --> 00:38:34,200 -You know, Rosalind Franklin 689 00:38:34,233 --> 00:38:37,333 had that famous photograph for eight months 690 00:38:37,366 --> 00:38:40,033 and never concluded it was the helix. 691 00:38:42,133 --> 00:38:43,433 You know... 692 00:38:43,466 --> 00:38:45,300 it's just stupid! 693 00:38:45,333 --> 00:38:47,766 -She was very devoted to hard evidence. 694 00:38:47,800 --> 00:38:49,666 She didn't want to make any claim 695 00:38:49,700 --> 00:38:51,800 for anything without hard evidence. 696 00:38:51,833 --> 00:38:55,433 And part of that may be because she was a female scientist. 697 00:38:57,333 --> 00:39:00,800 -This idea of having to hold so close the work 698 00:39:00,833 --> 00:39:03,500 that you're doing and the scrutiny 699 00:39:03,533 --> 00:39:07,033 that it might get since you are female -- 700 00:39:07,066 --> 00:39:08,433 I could relate to this idea 701 00:39:08,466 --> 00:39:11,400 that I'm gonna keep everything very close 702 00:39:11,433 --> 00:39:13,866 until it can be checked a thousand times over 703 00:39:13,900 --> 00:39:16,500 before I share it. 704 00:39:16,533 --> 00:39:18,566 -I think we all know that if you're from 705 00:39:18,600 --> 00:39:21,733 a marginalized group and you make a mistake, 706 00:39:21,766 --> 00:39:23,300 that could be the end of your career, 707 00:39:23,333 --> 00:39:26,300 whereas, you know, if you're from a privileged group 708 00:39:26,333 --> 00:39:29,033 and you make a mistake, "Eh." 709 00:39:29,066 --> 00:39:31,633 -Well... 710 00:39:31,666 --> 00:39:34,866 she -- she just botched it. 711 00:39:34,900 --> 00:39:37,366 She basically threw me out of her office 712 00:39:37,400 --> 00:39:40,700 when I said DNA is a helix. 713 00:39:40,733 --> 00:39:44,933 So, you know, she was -- 714 00:39:44,966 --> 00:39:46,733 she was pig-headed. 715 00:39:48,133 --> 00:39:51,233 -She had this gorgeous data, a beautiful, 716 00:39:51,266 --> 00:39:57,433 essential piece of data, but she was, um, isolated. 717 00:40:00,466 --> 00:40:01,833 -The men obviously had a network 718 00:40:01,866 --> 00:40:04,700 because it was a men's kind of job. 719 00:40:06,300 --> 00:40:09,133 The men were free to interact, to listen, 720 00:40:09,166 --> 00:40:11,000 and they were in their boys' club, 721 00:40:11,033 --> 00:40:13,166 and without that, nothing would have happened. 722 00:40:13,200 --> 00:40:16,100 -They talk about the discussions over lunch every day... 723 00:40:16,133 --> 00:40:17,366 -I remember this conversation 724 00:40:17,400 --> 00:40:19,366 was in the dining room of our house. 725 00:40:19,400 --> 00:40:20,700 We were sitting in a pub. 726 00:40:20,733 --> 00:40:24,033 -...you know, walking to play tennis. 727 00:40:24,066 --> 00:40:27,366 -I met him a little later in the tea queue at the Cavendish. 728 00:40:27,400 --> 00:40:30,333 -And so if you're not part of those discussions, 729 00:40:30,366 --> 00:40:32,766 it makes it a lot harder. 730 00:40:32,800 --> 00:40:34,700 -Watson's great strength was his ability 731 00:40:34,733 --> 00:40:40,733 to synthesize the various observations surrounding DNA 732 00:40:40,766 --> 00:40:43,666 such that he could work out the structure of DNA. 733 00:40:43,700 --> 00:40:49,266 -And the next morning, I came in and started playing with models, 734 00:40:49,300 --> 00:40:52,366 and then I discovered that you could put adenine 735 00:40:52,400 --> 00:40:54,933 and thymine together in exactly the same way 736 00:40:54,966 --> 00:40:56,966 you could put guanine and cytosine together. 737 00:40:57,000 --> 00:40:59,933 -Jim realized that the shape of an A-T base pair 738 00:40:59,966 --> 00:41:03,533 and a G-C base pair was exactly the same. 739 00:41:03,566 --> 00:41:06,233 -Everything from then on was clear. 740 00:41:06,266 --> 00:41:12,566 ## 741 00:41:12,600 --> 00:41:18,933 ## 742 00:41:18,966 --> 00:41:22,300 -February 28, 1953, is the day 743 00:41:22,333 --> 00:41:25,700 that they solved the structure of the double helix. 744 00:41:29,733 --> 00:41:32,466 -Crick was famous for walking into the Eagle bar and saying, 745 00:41:32,500 --> 00:41:34,500 "We've discovered the secret of life!" 746 00:41:38,033 --> 00:41:40,200 -We used to occasionally, just Jim and I, 747 00:41:40,233 --> 00:41:43,333 just sit and look at the molecule 748 00:41:43,366 --> 00:41:45,966 and think how beautiful it was. 749 00:41:46,000 --> 00:41:49,533 And I remember an occasion when Jim gave a talk 750 00:41:49,566 --> 00:41:51,133 to a little bar physics club we had. 751 00:41:51,166 --> 00:41:54,066 It's true they gave him one or two drinks before dinner. 752 00:41:54,100 --> 00:41:56,233 It was rather a short talk because all he could say 753 00:41:56,266 --> 00:41:59,200 at the end was, "Well, you see, it's so pretty. 754 00:41:59,233 --> 00:42:00,466 It's so pretty." 755 00:42:02,933 --> 00:42:04,866 -You see a lot of stuff about the Nobel Prize 756 00:42:04,900 --> 00:42:07,866 and rivalry with Pauling in "The Double Helix." 757 00:42:07,900 --> 00:42:11,266 I actually think their motivation was purer than 758 00:42:11,300 --> 00:42:12,900 is actually portrayed. 759 00:42:12,933 --> 00:42:14,400 I think they were thinking, 760 00:42:14,433 --> 00:42:18,566 "We've got an intuition about what's important in biology, 761 00:42:18,600 --> 00:42:20,033 and we're gonna carry that forward." 762 00:42:20,066 --> 00:42:22,433 I don't think they were thinking, "Nobel Prize." 763 00:42:22,466 --> 00:42:25,333 -I think you could say within five seconds 764 00:42:25,366 --> 00:42:28,700 we knew we should have a Nobel Prize. 765 00:42:28,733 --> 00:42:32,700 Well, we got the Nobel Prize in 1962, 766 00:42:32,733 --> 00:42:37,800 so that was nine years after the discovery. 767 00:42:37,833 --> 00:42:43,066 It was Francis and I and Maurice Wilkins. 768 00:42:43,100 --> 00:42:45,266 And you could say, "Well, what did he do 769 00:42:45,300 --> 00:42:47,233 to deserve a Nobel Prize?" 770 00:42:48,533 --> 00:42:50,700 But, in fact, we couldn't have done it 771 00:42:50,733 --> 00:42:53,066 if Wilkins hadn't started it. 772 00:42:54,866 --> 00:43:01,366 -Maybe had there been more of a collaborative environment, 773 00:43:01,400 --> 00:43:06,766 then everyone might have made it to the finish line together. 774 00:43:06,800 --> 00:43:08,266 -Rosalind was bright. 775 00:43:08,300 --> 00:43:12,766 She had all the intelligence you need to solve the problem. 776 00:43:12,800 --> 00:43:17,166 She just didn't make friends easy. 777 00:43:17,200 --> 00:43:22,800 -If she had had a real friend who was intelligent, 778 00:43:22,833 --> 00:43:25,100 they would have probably told her 779 00:43:25,133 --> 00:43:28,766 on a couple of occasions, "You're an ass." 780 00:43:28,800 --> 00:43:35,466 -Later, much later, the myth had arisen that 781 00:43:35,500 --> 00:43:41,500 Jim Watson and Francis Crick had stolen her work, 782 00:43:41,533 --> 00:43:45,033 which is basically nonsense. 783 00:43:45,066 --> 00:43:47,733 -Watson did not break in to Franklin's office 784 00:43:47,766 --> 00:43:49,666 and pilfer photographs. 785 00:43:49,700 --> 00:43:51,500 -Wilkins showed it to Watson 786 00:43:51,533 --> 00:43:55,133 without Rosalind Franklin's knowledge. 787 00:43:55,166 --> 00:43:58,266 -Wilkins showed it to me 'cause he was so frustrated 788 00:43:58,300 --> 00:44:03,133 that Rosalind wasn't following up her X-ray picture. 789 00:44:03,166 --> 00:44:05,733 You shouldn't look at it until you get permission, 790 00:44:05,766 --> 00:44:08,400 but you can't see something 791 00:44:08,433 --> 00:44:11,466 so potentially exciting without thinking about it. 792 00:44:11,500 --> 00:44:14,000 I would just say that's against human nature. 793 00:44:14,033 --> 00:44:16,600 -He didn't steal it, you know, but he didn't acknowledge it. 794 00:44:16,633 --> 00:44:18,100 That's the point. 795 00:44:18,133 --> 00:44:20,966 I mean, normally in science, you acknowledge the data you get. 796 00:44:21,000 --> 00:44:24,366 And probably he should have contacted her and asked, right, 797 00:44:24,400 --> 00:44:26,466 "Are you happy if we use it?" 798 00:44:26,500 --> 00:44:29,200 This is clearly unethical behavior in science. 799 00:44:29,233 --> 00:44:31,800 -By modern scientific standards, we would have actually 800 00:44:31,833 --> 00:44:35,733 considered this an example of scientific malfeasance. 801 00:44:35,766 --> 00:44:37,800 Showing another scientist's data without their permission 802 00:44:37,833 --> 00:44:39,600 is not something that's allowed today. 803 00:44:39,633 --> 00:44:43,433 But in that climate, under those circumstances, 804 00:44:43,466 --> 00:44:45,266 it wasn't considered that. 805 00:44:45,300 --> 00:44:47,833 -When a woman made a scientific discovery, 806 00:44:47,866 --> 00:44:51,066 it often was not credited to her. 807 00:44:51,100 --> 00:44:54,666 She wasn't valued in the same way that men were who made that. 808 00:44:54,700 --> 00:44:57,366 Women's scientific discoveries 809 00:44:57,400 --> 00:44:58,966 didn't even belong to them, really. 810 00:44:59,000 --> 00:45:01,733 They were just there for the taking. 811 00:45:01,766 --> 00:45:03,466 They belonged to the air. 812 00:45:05,700 --> 00:45:08,266 -If we didn't exist, then she would be 813 00:45:08,300 --> 00:45:12,133 the most famous woman scientist ever to live. 814 00:45:12,166 --> 00:45:16,600 So, that's a big loss that women don't have her. 815 00:45:16,633 --> 00:45:19,233 -Of course, the greatest tragedy of why 816 00:45:19,266 --> 00:45:21,500 she couldn't have been nominated for the Nobel Prize 817 00:45:21,533 --> 00:45:26,166 was the fact that she died before the structure of DNA 818 00:45:26,200 --> 00:45:28,366 was considered for a Nobel Prize. 819 00:45:30,600 --> 00:45:34,133 -She died of cancer at a very young age, 820 00:45:34,166 --> 00:45:36,300 well before they got the Nobel Prize, 821 00:45:36,333 --> 00:45:39,866 and probably died in part because of the science 822 00:45:39,900 --> 00:45:43,866 she was doing that involved X-rays and radiation. 823 00:45:48,866 --> 00:45:52,966 -Jim used to say science is a young person's game. 824 00:45:53,000 --> 00:45:57,466 And, you know, he discovered the double helix at the age of 25, 825 00:45:57,500 --> 00:45:59,433 won the Nobel Prize at a very young age, 826 00:45:59,466 --> 00:46:01,733 and most people would have sat on their laurels. 827 00:46:01,766 --> 00:46:03,400 Jim didn't. 828 00:46:05,500 --> 00:46:09,433 He came here because I think he wanted to run his own shop, 829 00:46:09,466 --> 00:46:11,266 if you will 830 00:46:11,300 --> 00:46:14,900 and have a direction and an influence. 831 00:46:14,933 --> 00:46:17,566 -I think except when I'm playing tennis. 832 00:46:17,600 --> 00:46:21,000 I spend my whole life thinking. 833 00:46:21,033 --> 00:46:22,666 That's all I want to do. 834 00:46:24,766 --> 00:46:28,533 -This is a place where you can set the stage 835 00:46:28,566 --> 00:46:31,400 for what's going on in science. 836 00:46:31,433 --> 00:46:37,466 -My own desire was to understand cancer viruses 837 00:46:37,500 --> 00:46:41,033 and then probably understanding cancer genes 838 00:46:41,066 --> 00:46:43,200 as fast as possible. 839 00:46:43,233 --> 00:46:46,566 I had seen my father's younger brother die of melanoma, 840 00:46:46,600 --> 00:46:50,133 and, you know, it's awful. 841 00:46:50,166 --> 00:46:52,266 Oh, Matt, we shouldn't have waited 842 00:46:52,300 --> 00:46:54,033 till the drug gets approval. 843 00:46:54,066 --> 00:46:56,966 You know, that could be another year from now. 844 00:46:57,000 --> 00:47:02,700 And I have a self-interest in trying to explain to them 845 00:47:02,733 --> 00:47:05,933 that, you know, I'm still alive. 846 00:47:05,966 --> 00:47:08,833 Even though I will soon be 90, 847 00:47:08,866 --> 00:47:12,733 I'm trying to be at the frontier. 848 00:47:14,233 --> 00:47:18,300 -Jim was one of the scientists, very prominent scientists -- 849 00:47:18,333 --> 00:47:19,900 he had already won a Nobel Prize -- 850 00:47:19,933 --> 00:47:22,500 who was working on trying to influence Congress 851 00:47:22,533 --> 00:47:24,066 but particularly the president 852 00:47:24,100 --> 00:47:27,700 on putting much more funding into cancer... 853 00:47:27,733 --> 00:47:30,166 -We are here today for the purpose of signing 854 00:47:30,200 --> 00:47:32,600 the Cancer Act of 1971. 855 00:47:32,633 --> 00:47:35,266 -...now known as the so-called "war on cancer." 856 00:47:35,300 --> 00:47:37,066 -We don't have to tell House and Senate members 857 00:47:37,100 --> 00:47:38,333 how to get in the picture. 858 00:47:38,366 --> 00:47:39,766 [ Laughter ] 859 00:47:39,800 --> 00:47:40,900 -To my amazement, all of a sudden, 860 00:47:40,933 --> 00:47:42,366 Jim was going to start a whole lab 861 00:47:42,400 --> 00:47:45,233 devoted to understanding cancer at the molecular level. 862 00:47:45,266 --> 00:47:49,100 -Even before the DNA structure, I was conscious that, probably, 863 00:47:49,133 --> 00:47:52,800 cancer was a genetic disease that ran in families, 864 00:47:52,833 --> 00:47:58,966 so I thought cancer would be understood through DNA analysis. 865 00:47:59,000 --> 00:48:01,266 -And he needed more resources than he could get at Harvard, 866 00:48:01,300 --> 00:48:04,433 so he was gonna go to Cold Spring Harbor. 867 00:48:06,633 --> 00:48:09,066 -You know, I've always loved Cold Spring Harbor. 868 00:48:11,566 --> 00:48:13,966 I had come here at the end of my first year 869 00:48:14,000 --> 00:48:17,900 of graduate school, and I was 20 years old. 870 00:48:20,166 --> 00:48:24,266 It had been the first place for genetics 871 00:48:24,300 --> 00:48:25,933 in the United States. 872 00:48:28,266 --> 00:48:30,566 -Cold Spring Harbor Laboratory was founded in 1890, 873 00:48:30,600 --> 00:48:35,066 and for 60 years, it was funded by Andrew Carnegie's foundation. 874 00:48:35,100 --> 00:48:37,400 Huge, important work done here. 875 00:48:40,966 --> 00:48:43,533 But when the Carnegie Foundation pulled out, 876 00:48:43,566 --> 00:48:45,033 the laboratory was almost broken. 877 00:48:45,066 --> 00:48:48,000 In fact, almost closed. 878 00:48:48,033 --> 00:48:52,200 -The plumbing didn't work. The lawns were overgrown. 879 00:48:52,233 --> 00:48:53,866 The paint was peeling. 880 00:48:53,900 --> 00:48:56,433 It was on the verge of bankruptcy. 881 00:48:56,466 --> 00:49:02,500 -When it began to fail, I didn't want to see it fail. 882 00:49:02,533 --> 00:49:05,533 -One of Jim Watson's goals has been the directorship 883 00:49:05,566 --> 00:49:08,300 of the Cold Spring Harbor Biological Laboratories 884 00:49:08,333 --> 00:49:09,866 on Long Island. 885 00:49:09,900 --> 00:49:12,100 -Jim took over the lab. 886 00:49:12,133 --> 00:49:18,366 In November of 1967, hubby-pie Watson 887 00:49:18,400 --> 00:49:21,800 brought me to Cold Spring Harbor on our honeymoon. 888 00:49:23,800 --> 00:49:27,166 He said he would run Cold Spring Harbor Lab 889 00:49:27,200 --> 00:49:29,433 for three years, and if he hadn't built up 890 00:49:29,466 --> 00:49:33,233 an endowment for the lab, he'd just go back to Harvard. 891 00:49:33,266 --> 00:49:37,466 -He started courting the neighbors and getting donations. 892 00:49:37,500 --> 00:49:40,600 He is actually pretty good at currying favor 893 00:49:40,633 --> 00:49:43,366 with rich people and powerful people. 894 00:49:43,400 --> 00:49:48,466 He learned to be a little odd, to say funny things, 895 00:49:48,500 --> 00:49:51,466 and they like him better. 896 00:49:51,500 --> 00:49:56,066 There's this piece of Watson lore that everybody knows. 897 00:49:56,100 --> 00:49:59,133 -That he sometimes purposefully untied his shoes 898 00:49:59,166 --> 00:50:00,566 before he entered a room. 899 00:50:00,600 --> 00:50:02,433 -Before he'd go in, he would stop 900 00:50:02,466 --> 00:50:06,566 and mess up his hair and untie his shoelaces. 901 00:50:06,600 --> 00:50:08,100 -The untied shoelaces. 902 00:50:08,133 --> 00:50:10,633 -He'll deliberately untie his shoes and mess up his hair 903 00:50:10,666 --> 00:50:13,633 so he's the stereotypical mad scientist 904 00:50:13,666 --> 00:50:14,900 as he goes to meet with them. 905 00:50:14,933 --> 00:50:17,666 -To give them what they were paying for. 906 00:50:17,700 --> 00:50:20,700 -He wouldn't do it on purpose. 907 00:50:20,733 --> 00:50:23,733 You know, he's an absent-minded scientist. 908 00:50:23,766 --> 00:50:26,633 I imagine it's in his DNA. 909 00:50:26,666 --> 00:50:29,466 -Jim stormed in to Cold Spring Harbor 910 00:50:29,500 --> 00:50:34,000 and went to work with unbelievable energy. 911 00:50:37,766 --> 00:50:41,700 Suddenly, it was vibrant. It was growing. 912 00:50:41,733 --> 00:50:44,166 -Under his leadership, Cold Spring Harbor became 913 00:50:44,200 --> 00:50:50,166 a focus for molecular genetic research at a world level. 914 00:50:50,200 --> 00:50:52,000 -I was giving my job interview here, 915 00:50:52,033 --> 00:50:55,566 and, at some point, I realize there's somebody 916 00:50:55,600 --> 00:50:58,766 yawning extremely loudly in the first row... 917 00:50:58,800 --> 00:51:01,066 [ Yawns ] 918 00:51:01,100 --> 00:51:03,000 ...throughout my talk. 919 00:51:03,033 --> 00:51:05,633 And so I realize, "Oh, this is Jim." 920 00:51:05,666 --> 00:51:08,233 He was trying to say that, "You know, this cancer stuff 921 00:51:08,266 --> 00:51:10,800 that you're presenting is so boring. 922 00:51:10,833 --> 00:51:15,766 Give me something that actually matters and makes a difference." 923 00:51:15,800 --> 00:51:17,800 -There are very few institutions in the world 924 00:51:17,833 --> 00:51:20,466 that have such a big influence. 925 00:51:20,500 --> 00:51:23,200 I mean, we've got DNA money sent to us in Singapore 926 00:51:23,233 --> 00:51:28,266 and China and Vienna and around the United States. 927 00:51:28,300 --> 00:51:29,533 You know, just on Long Island alone, 928 00:51:29,566 --> 00:51:32,366 we educate 32,000 kids a year. 929 00:51:32,400 --> 00:51:35,300 -In our school, we had the Meeting of the Minds Project... 930 00:51:35,333 --> 00:51:36,866 -Yeah. -...which is basically where 931 00:51:36,900 --> 00:51:38,400 people dress up as someone. 932 00:51:38,433 --> 00:51:41,300 Like, my brother did Beethoven, and I did you. 933 00:51:41,333 --> 00:51:44,333 -Oh. We should get a picture together. 934 00:51:46,500 --> 00:51:47,933 Say, "DNA." 935 00:51:47,966 --> 00:51:49,200 -DNA! 936 00:51:49,233 --> 00:51:50,633 # I got, I got, I got 937 00:51:50,666 --> 00:51:54,033 # I got loyalty, got royalty inside my DNA # 938 00:51:54,066 --> 00:51:58,166 -Watson has been DNA's front man for 50 years. 939 00:51:58,200 --> 00:52:00,266 That's because of the "Double Helix" book. 940 00:52:00,300 --> 00:52:02,733 That's because of his work at Cold Spring Harbor. 941 00:52:02,766 --> 00:52:05,866 [ Applause ] 942 00:52:05,900 --> 00:52:07,166 -James Watson. 943 00:52:07,200 --> 00:52:09,000 [ Cheers and applause ] 944 00:52:09,033 --> 00:52:11,533 -He made DNA "DNA." 945 00:52:15,266 --> 00:52:16,866 -Dino DNA. 946 00:52:16,900 --> 00:52:23,033 ## 947 00:52:23,066 --> 00:52:25,100 -Even if you don't know anything about genetics, 948 00:52:25,133 --> 00:52:26,966 you can say, "Oh, it's in his DNA." 949 00:52:27,000 --> 00:52:29,200 -Sometimes I feel like I have comedy in my genes. 950 00:52:29,233 --> 00:52:31,866 -If you want to find out who you are, 951 00:52:31,900 --> 00:52:33,733 you can get your DNA sequenced. 952 00:52:33,766 --> 00:52:35,400 -Jewish?! 953 00:52:37,933 --> 00:52:40,900 -So now, all of a sudden, people have a molecule 954 00:52:40,933 --> 00:52:46,400 that they can put all of their beliefs about heredity on. 955 00:52:49,666 --> 00:52:53,233 -I wanted to marry somebody smart so my kids would be smart. 956 00:52:55,566 --> 00:52:58,566 I got a phone call from my gynecologist, and he said, 957 00:52:58,600 --> 00:53:01,300 "Well, the future president of the United States 958 00:53:01,333 --> 00:53:02,800 is on his way." 959 00:53:04,666 --> 00:53:10,333 In the winter of '70, Rufus was born. 960 00:53:10,366 --> 00:53:15,266 -Everyone was in agreement that Rufus was pretty bright, 961 00:53:15,300 --> 00:53:21,166 and I was very pleased, because, you know, for a while, 962 00:53:21,200 --> 00:53:23,700 he would go birdwatching with me, 963 00:53:23,733 --> 00:53:27,700 and we had some relationship. 964 00:53:31,366 --> 00:53:33,800 -Jim used to use the expression 965 00:53:33,833 --> 00:53:36,700 "A bad roll of the genetic dice," 966 00:53:36,733 --> 00:53:38,366 and, in fact... 967 00:53:40,900 --> 00:53:46,166 ...genetically, Rufus did -- he was dealt a bad hand. 968 00:53:46,200 --> 00:53:49,666 -My son was damaged at birth. 969 00:53:49,700 --> 00:53:52,233 He was having difficulty interacting with people 970 00:53:52,266 --> 00:53:54,300 when he was 3. 971 00:53:58,266 --> 00:53:59,800 When he was 10 years old, 972 00:53:59,833 --> 00:54:04,700 he began to have some sort of social problems. 973 00:54:04,733 --> 00:54:10,000 The school suggested we take him to a local child psychologist, 974 00:54:10,033 --> 00:54:17,133 and we had and, uh, just hoped it would all disappear. 975 00:54:18,466 --> 00:54:21,066 -In 10th grade, he had a full-blown 976 00:54:21,100 --> 00:54:26,366 psychotic event at Exeter, and they sent him home. 977 00:54:28,933 --> 00:54:32,500 -He came home, and we put him in the local high school, 978 00:54:32,533 --> 00:54:35,266 and three days later, 979 00:54:35,300 --> 00:54:41,500 he took himself into the World Trade Center, 980 00:54:41,533 --> 00:54:45,333 where he went to the top with the hope of ending his life. 981 00:54:47,066 --> 00:54:52,433 -We realized that Rufus was very, very, very ill. 982 00:54:52,466 --> 00:54:56,700 -They said he had sort of abnormalities 983 00:54:56,733 --> 00:55:00,633 which you frequently find in schizophrenia. 984 00:55:00,666 --> 00:55:08,566 -I had never seen Jim weep before or since in his life, 985 00:55:08,600 --> 00:55:10,900 and, you know, this kind of emotion 986 00:55:10,933 --> 00:55:15,500 is not something that I'm used to seeing from Jim, you know? 987 00:55:17,166 --> 00:55:22,900 He wanted Rufus cured, and I just wanted Rufus to feel loved. 988 00:55:22,933 --> 00:55:25,500 You know, that's the difference. 989 00:55:25,533 --> 00:55:30,966 Moms tend to be -- They just want to love their children, 990 00:55:31,000 --> 00:55:34,400 and men try to fix things. 991 00:55:36,033 --> 00:55:39,100 -I don't want to, in any sense, be ashamed of him, 992 00:55:39,133 --> 00:55:40,600 which I am not. 993 00:55:40,633 --> 00:55:44,100 You know, he's really a very lovable child, you know, 994 00:55:44,133 --> 00:55:47,900 and he's a nice person, as well as being very bright. 995 00:55:52,233 --> 00:55:55,800 -Now, in this -- in this series, I mean, 996 00:55:55,833 --> 00:55:59,033 obviously, I'll be labeled as a schizo, right? 997 00:55:59,066 --> 00:56:02,233 I mean, that would be truth in advertising right? 998 00:56:02,266 --> 00:56:04,666 My dad will tell people, "Oh, my son Rufus -- 999 00:56:04,700 --> 00:56:07,200 he's bright, but he's mentally ill," 1000 00:56:07,233 --> 00:56:08,966 whereas I think of it as the opposite. 1001 00:56:09,000 --> 00:56:12,900 I think I'm dim but not mentally ill. 1002 00:56:12,933 --> 00:56:15,533 And so -- 1003 00:56:15,566 --> 00:56:17,033 -No, it's unfair. You're the kind of person 1004 00:56:17,066 --> 00:56:19,533 that -- that, uh -- 1005 00:56:19,566 --> 00:56:23,000 that Pop has, like, fought for his, like, whole career. 1006 00:56:23,033 --> 00:56:26,866 -Much human disease has a genetic origin. 1007 00:56:26,900 --> 00:56:30,833 It's likely that mental illness is not caused by one gene, 1008 00:56:30,866 --> 00:56:34,900 but there may be hundreds if not thousands of them, 1009 00:56:34,933 --> 00:56:39,933 and so I would like to know, where did his DNA go wrong? 1010 00:56:39,966 --> 00:56:42,033 -Good evening. History will mark this day 1011 00:56:42,066 --> 00:56:44,900 as a milestone in medicine and science. 1012 00:56:44,933 --> 00:56:47,766 Researchers have decoded the human genome. 1013 00:56:47,800 --> 00:56:51,166 That's the sequence of billions of DNA fragments 1014 00:56:51,200 --> 00:56:53,300 that are the recipe for humankind. 1015 00:56:53,333 --> 00:56:57,366 -The seeds of the Human Genome Project were essentially sewn 1016 00:56:57,400 --> 00:57:01,933 on February 28, 1953, when Watson and Crick 1017 00:57:01,966 --> 00:57:03,900 walked into the pub and Crick said, 1018 00:57:03,933 --> 00:57:06,066 "We've discovered the secret of life!" 1019 00:57:06,100 --> 00:57:09,366 -We have about 22,000 genes. 1020 00:57:09,400 --> 00:57:11,933 Working out what each of these does, 1021 00:57:11,966 --> 00:57:14,200 we'll find out what we are. 1022 00:57:14,233 --> 00:57:17,466 -In 1986, Jim Watson had organized 1023 00:57:17,500 --> 00:57:19,600 the famous Cold Spring Harbor Symposium 1024 00:57:19,633 --> 00:57:22,666 here at Cold Spring Harbor on the human genome. 1025 00:57:22,700 --> 00:57:28,633 -It was really mental illness that was the reason why I was 1026 00:57:28,666 --> 00:57:30,133 so keen to get it started. 1027 00:57:30,166 --> 00:57:32,000 -Jim didn't actually get to go to that session 1028 00:57:32,033 --> 00:57:36,866 because Rufus had run away the night before, 1029 00:57:36,900 --> 00:57:40,733 and Jim and Liz were out hunting for Rufus. 1030 00:57:42,233 --> 00:57:44,833 -He brought the world's most influential 1031 00:57:44,866 --> 00:57:46,966 human geneticists together, 1032 00:57:47,000 --> 00:57:50,100 and he decided to have an afternoon of discussion 1033 00:57:50,133 --> 00:57:52,800 about whether we really should sequence the human genome, 1034 00:57:52,833 --> 00:57:54,400 because there was a lot of opposition 1035 00:57:54,433 --> 00:57:56,500 from very prominent scientists. 1036 00:57:56,533 --> 00:58:00,266 -The scale was outrageously beyond anything 1037 00:58:00,300 --> 00:58:03,100 that seemed achievable, so it was only people 1038 00:58:03,133 --> 00:58:06,200 who were willing to think way outside of reality 1039 00:58:06,233 --> 00:58:09,800 that could develop enough momentum to make it happen. 1040 00:58:09,833 --> 00:58:12,433 -A small group of us came together and asked, 1041 00:58:12,466 --> 00:58:14,366 "Okay, if this was going to happen, 1042 00:58:14,400 --> 00:58:16,966 who should be the person who leads it?" 1043 00:58:17,000 --> 00:58:20,033 And we all agreed Jim Watson. 1044 00:58:20,066 --> 00:58:21,866 It's obvious. It's perfect. 1045 00:58:21,900 --> 00:58:23,900 It's so poetic. 1046 00:58:23,933 --> 00:58:25,433 -Jim saw the end game. 1047 00:58:25,466 --> 00:58:29,233 He saw that he could go from discovering the double helix 1048 00:58:29,266 --> 00:58:34,166 to having, in his lifetime, a sequence of the human genome. 1049 00:58:34,200 --> 00:58:37,233 He had that confidence again that we could do it 1050 00:58:37,266 --> 00:58:39,233 even though we didn't know how to do it. 1051 00:58:39,266 --> 00:58:40,566 -And then there got to be 1052 00:58:40,600 --> 00:58:43,733 this tense disagreement about patenting. 1053 00:58:43,766 --> 00:58:45,933 -Tonight's "Eye on America" takes you to the frontiers 1054 00:58:45,966 --> 00:58:50,466 of science news -- locating the 100,000 genes. 1055 00:58:50,500 --> 00:58:54,833 Can those who discover it all patent and own it? 1056 00:58:54,866 --> 00:58:58,000 -His boss was Bernadine Healy, who supports the patent. 1057 00:58:58,033 --> 00:59:00,766 -She's Clint Eastwood in suits and high heels -- 1058 00:59:00,800 --> 00:59:03,466 dressed for tea, ready for combat. 1059 00:59:03,500 --> 00:59:08,366 -Jim Watson was emotionally violently opposed to that. 1060 00:59:10,866 --> 00:59:13,266 -She was a highly intelligent woman 1061 00:59:13,300 --> 00:59:20,033 who I just thought doesn't know as much as I do, 1062 00:59:20,066 --> 00:59:21,933 and she acts as if she does. 1063 00:59:21,966 --> 00:59:24,400 -He said, "No. DNA is very special. 1064 00:59:24,433 --> 00:59:26,366 It's the storage and transmission medium 1065 00:59:26,400 --> 00:59:30,400 of biological information, so you can't patent it." 1066 00:59:30,433 --> 00:59:32,800 But you know what? She's his boss, 1067 00:59:32,833 --> 00:59:36,433 and they're on opposite sides of this patenting thing, 1068 00:59:36,466 --> 00:59:39,266 but they're on opposite sides of a lot of things. 1069 00:59:39,300 --> 00:59:44,200 The patent story became a very public controversy, 1070 00:59:44,233 --> 00:59:46,166 and in a way, one of them had to lose. 1071 00:59:46,200 --> 00:59:48,566 -Do you swear to tell the truth, the whole truth, 1072 00:59:48,600 --> 00:59:51,233 and nothing but the truth, so help you, God? 1073 00:59:51,266 --> 00:59:54,766 -Some of us have a governor on what we decide 1074 00:59:54,800 --> 00:59:57,533 we're going to articulate that we might be thinking 1075 00:59:57,566 --> 01:00:00,866 but maybe wouldn't think it's time to say it. 1076 01:00:00,900 --> 01:00:05,200 Jim's governor was perhaps a little harder to perceive. 1077 01:00:05,233 --> 01:00:07,266 And there were times when he would, 1078 01:00:07,300 --> 01:00:11,600 in a very blunt way and a dismissive way, offend people. 1079 01:00:11,633 --> 01:00:14,600 And he, I gather, called her a lunatic, 1080 01:00:14,633 --> 01:00:18,900 not once but more than once, in front of open microphones. 1081 01:00:18,933 --> 01:00:22,866 -Not a good way to make friends and influence people. 1082 01:00:26,200 --> 01:00:28,433 -Jim has a penchant for opening his mouth 1083 01:00:28,466 --> 01:00:30,066 and sticking his foot in it. 1084 01:00:30,100 --> 01:00:33,600 -What I call "foot in mouth disease." 1085 01:00:35,066 --> 01:00:37,866 He got himself in a lot of trouble a few times. 1086 01:00:39,766 --> 01:00:43,933 -I'm just not afraid to say what I think. 1087 01:00:43,966 --> 01:00:48,166 -He and Dr. Healy had a history, so they didn't come into this 1088 01:00:48,200 --> 01:00:51,466 with a warm and fuzzy relationship. 1089 01:00:51,500 --> 01:00:54,600 She basically had it and said, "We're done with you, 1090 01:00:54,633 --> 01:00:57,933 and if you don't resign, we will figure out a way 1091 01:00:57,966 --> 01:01:01,500 to get you out of here that won't be pretty." 1092 01:01:01,533 --> 01:01:06,866 -In March 1992, he sends in his resignation. 1093 01:01:06,900 --> 01:01:08,833 It was a dark day. 1094 01:01:08,866 --> 01:01:12,333 This project was barely out of the gates. 1095 01:01:12,366 --> 01:01:14,766 This is like a baby still in the crib. 1096 01:01:14,800 --> 01:01:17,433 And Daddy just left. 1097 01:01:17,466 --> 01:01:20,333 Jim certainly had offended a fair number of people, 1098 01:01:20,366 --> 01:01:24,366 and it was necessary for me to do some repairs there. 1099 01:01:24,400 --> 01:01:26,533 But I benefited greatly by the fact 1100 01:01:26,566 --> 01:01:29,533 that he was the initiator 1101 01:01:29,566 --> 01:01:33,033 of a lot of what I then got to take on. 1102 01:01:33,066 --> 01:01:34,900 [ Applause ] 1103 01:01:34,933 --> 01:01:39,466 We declared victory of the completed Human Genome Project 1104 01:01:39,500 --> 01:01:43,000 goals in April of 2003. 1105 01:01:43,033 --> 01:01:52,666 ## 1106 01:01:52,700 --> 01:01:55,100 -I don't think the genome program would have come up 1107 01:01:55,133 --> 01:01:58,633 with any answer for my condition. 1108 01:02:00,800 --> 01:02:03,733 I mean, my dad was successful, so I always assumed 1109 01:02:03,766 --> 01:02:06,433 that I would be successful at what I tried to do. 1110 01:02:07,800 --> 01:02:09,900 -Yeah, me too. You make that assumption. 1111 01:02:09,933 --> 01:02:12,266 You kind of grow up and you think, "Wow," you know? 1112 01:02:12,300 --> 01:02:14,233 "This Watson -- this is family thing, right? 1113 01:02:14,266 --> 01:02:16,033 He's extraordinary, 1114 01:02:16,066 --> 01:02:20,966 and, you know, it's my genetic destiny." 1115 01:02:21,000 --> 01:02:24,166 And then, at a certain point, you know, I started to -- 1116 01:02:24,200 --> 01:02:25,766 "Oh, gee, 1117 01:02:25,800 --> 01:02:27,733 I wonder when I'm gonna have my big ideas or something." 1118 01:02:27,766 --> 01:02:31,266 And then, you know, that passed pretty quickly. 1119 01:02:31,300 --> 01:02:34,966 -I thought that I'd be smart, but, you know, 1120 01:02:35,000 --> 01:02:41,166 it wasn't until I became aware of how dim I was that I thought, 1121 01:02:41,200 --> 01:02:46,533 "Well, this is strange because my dad's not dim." 1122 01:02:46,566 --> 01:02:49,100 Then I thought, "Well, I'm a burden on my parents 1123 01:02:49,133 --> 01:02:50,400 because he's successful, 1124 01:02:50,433 --> 01:02:54,033 and doesn't he deserve a successful child 1125 01:02:54,066 --> 01:02:57,666 because he's worked hard, and, if you believe in karma, 1126 01:02:57,700 --> 01:03:01,533 then he should have earned himself a successful son." 1127 01:03:01,566 --> 01:03:06,533 ## 1128 01:03:09,933 --> 01:03:12,966 But, Pop, do you still consider yourself a scientist? 1129 01:03:13,000 --> 01:03:14,566 -Yes. 1130 01:03:15,800 --> 01:03:17,900 I'm probably still the best scientist here 1131 01:03:17,933 --> 01:03:19,566 in Cold Spring Harbor. 1132 01:03:21,966 --> 01:03:24,900 ## 1133 01:03:24,933 --> 01:03:29,666 -He came here when he was 20, and it's been his whole life. 1134 01:03:31,366 --> 01:03:33,233 -In an important way, Cold Spring Harbor 1135 01:03:33,266 --> 01:03:39,100 is Jim Watson, and he's very, very devoted to the place. 1136 01:03:39,133 --> 01:03:44,166 ## 1137 01:03:44,200 --> 01:03:47,000 I would say that it is one of the things 1138 01:03:47,033 --> 01:03:51,966 that he probably feels he's gonna be most remembered for. 1139 01:03:52,000 --> 01:03:57,366 ## 1140 01:03:57,400 --> 01:03:58,966 -Scientists on both sides of the Atlantic 1141 01:03:59,000 --> 01:04:01,033 are now up in arms over comments 1142 01:04:01,066 --> 01:04:05,133 quoted from the biologist and Nobel Laureate James Watson. 1143 01:04:05,166 --> 01:04:08,133 -Watson sparked a furor when the UK's The Sunday Times 1144 01:04:08,166 --> 01:04:09,566 quoted him saying, 1145 01:04:09,600 --> 01:04:12,566 "I'm inherently gloomy about the prospect of Africa," 1146 01:04:12,600 --> 01:04:15,633 adding, "All our social policies are based on the fact 1147 01:04:15,666 --> 01:04:18,300 that their intelligence is the same as ours, 1148 01:04:18,333 --> 01:04:20,700 whereas all the testing says not really." 1149 01:04:20,733 --> 01:04:23,300 -In 2007, he made... 1150 01:04:26,200 --> 01:04:29,766 ...some very unfortunate comments about 1151 01:04:29,800 --> 01:04:31,133 race and intelligence. 1152 01:04:31,166 --> 01:04:36,533 -It was like a bomb going off on campus, so, uh... 1153 01:04:36,566 --> 01:04:39,633 it sent everything kind of spinning. 1154 01:04:39,666 --> 01:04:44,233 -I thought, "Whoa. This is not good. 1155 01:04:44,266 --> 01:04:46,033 I mean, what's happened, you know? 1156 01:04:46,066 --> 01:04:48,700 Where's the Jim I knew?" 1157 01:04:48,733 --> 01:04:50,066 -And that wasn't all. 1158 01:04:50,100 --> 01:04:53,666 Watson was quoted as saying he hopes everyone is equal 1159 01:04:53,700 --> 01:04:55,400 but "People who have to deal 1160 01:04:55,433 --> 01:04:58,266 with black employees find this not true." 1161 01:05:00,166 --> 01:05:04,366 -He said anyone who has had black employees knows 1162 01:05:04,400 --> 01:05:06,466 that this is not the case. 1163 01:05:07,833 --> 01:05:11,666 Right. Just put the little... 1164 01:05:11,700 --> 01:05:14,200 dig right in there. Yeah. 1165 01:05:14,233 --> 01:05:16,700 -Tonight the Nobel Laureate's job at a prestigious laboratory 1166 01:05:16,733 --> 01:05:19,466 is on the line and his reputation is badly bruised. 1167 01:05:19,500 --> 01:05:21,166 Are there any studies or any tests 1168 01:05:21,200 --> 01:05:22,200 that support his statement? 1169 01:05:22,233 --> 01:05:23,633 I mean, what is he talking about? 1170 01:05:23,666 --> 01:05:26,600 -Well, he is talking about a literature that developed 1171 01:05:26,633 --> 01:05:30,666 over the 20th century in basic IQ testing 1172 01:05:30,700 --> 01:05:34,000 that does show a result of persons of European descent 1173 01:05:34,033 --> 01:05:36,933 and persons of East Asian descent in the United States 1174 01:05:36,966 --> 01:05:41,133 and also across Europe and Asia scoring higher on IQ tests 1175 01:05:41,166 --> 01:05:43,200 than persons of African descent. 1176 01:05:43,233 --> 01:05:45,300 Now, one has to be very careful, however, 1177 01:05:45,333 --> 01:05:48,433 about imputing a meaning to the differences in the results, 1178 01:05:48,466 --> 01:05:50,166 particularly a genetic meaning. 1179 01:05:50,200 --> 01:05:53,233 The most obvious causal factor 1180 01:05:53,266 --> 01:05:55,066 that would be accounting for the differences 1181 01:05:55,100 --> 01:05:57,900 in IQ test scores would be the physical environment 1182 01:05:57,933 --> 01:05:59,266 that the two groups live in. 1183 01:05:59,300 --> 01:06:02,100 In the United States, European-Americans 1184 01:06:02,133 --> 01:06:04,566 and African-Americans have never lived in the same 1185 01:06:04,600 --> 01:06:09,566 social, environmental, economic, and physical environments, 1186 01:06:09,600 --> 01:06:11,833 and, hence, any outcome from those tests 1187 01:06:11,866 --> 01:06:14,033 cannot be ascribed to genetic sources. 1188 01:06:14,066 --> 01:06:17,500 -The brain, it's a device. 1189 01:06:17,533 --> 01:06:19,366 Yes, the genes make the device, 1190 01:06:19,400 --> 01:06:23,300 but what it's capable of doing depends on having good nutrition 1191 01:06:23,333 --> 01:06:25,933 and 8 trillion things we don't begin to understand. 1192 01:06:25,966 --> 01:06:30,133 -Furthermore, it's not agreed upon by psychologists 1193 01:06:30,166 --> 01:06:35,533 that IQ tests are actually really measuring intelligence. 1194 01:06:35,566 --> 01:06:36,800 -Were you surprised to hear 1195 01:06:36,833 --> 01:06:38,066 Dr. Watson making these comments? 1196 01:06:38,100 --> 01:06:39,666 I mean, there is a history here of this man 1197 01:06:39,700 --> 01:06:42,566 making some very controversial statements. 1198 01:06:42,600 --> 01:06:44,466 -Well, in Watson's case here, 1199 01:06:44,500 --> 01:06:45,833 he's really talking about things, 1200 01:06:45,866 --> 01:06:47,866 personal beliefs and biases that he has 1201 01:06:47,900 --> 01:06:49,466 that he'd like to be true 1202 01:06:49,500 --> 01:06:51,433 and that there's really no scientific evidence for, 1203 01:06:51,466 --> 01:06:53,400 and I find that irresponsible. 1204 01:06:53,433 --> 01:06:56,366 I'm the first person of African-American descent 1205 01:06:56,400 --> 01:06:59,566 to have ever earned a PhD in evolutionary biology. 1206 01:06:59,600 --> 01:07:02,666 And when I was interviewed by Anderson Cooper, 1207 01:07:02,700 --> 01:07:06,100 I tried to maintain the scientific high ground 1208 01:07:06,133 --> 01:07:09,933 and not in the interview, um, 1209 01:07:09,966 --> 01:07:15,766 give to the viewing audience the pain that I feel every time 1210 01:07:15,800 --> 01:07:22,100 I read these words about how, because of my genetic heritage, 1211 01:07:22,133 --> 01:07:26,100 I can't be or am not as good a scientist as Watson was. 1212 01:07:27,500 --> 01:07:31,633 -For me, personally, he stands for -- in my world, 1213 01:07:31,666 --> 01:07:34,866 stands for critical, radical thought, 1214 01:07:34,900 --> 01:07:40,333 and, you know, how you can go back to a... 1215 01:07:40,366 --> 01:07:46,400 old, rooted notion, um... 1216 01:07:46,433 --> 01:07:50,033 that has nothing to do with critical thinking today -- 1217 01:07:50,066 --> 01:07:52,100 I don't know. I really don't know. 1218 01:07:52,133 --> 01:07:53,800 -It's not science-based, 1219 01:07:53,833 --> 01:07:56,866 and that's what makes you concerned that, 1220 01:07:56,900 --> 01:07:59,200 "What happened to cause him to say it?" 1221 01:08:01,566 --> 01:08:02,900 -We had been in the habit 1222 01:08:02,933 --> 01:08:06,800 of taking gap-year kids from England. 1223 01:08:06,833 --> 01:08:10,633 -And Jim and Liz had a young woman 1224 01:08:10,666 --> 01:08:13,233 who was staying with them for a year 1225 01:08:13,266 --> 01:08:15,733 who worked at the laboratory, 1226 01:08:15,766 --> 01:08:18,200 she went back and became a journalist. 1227 01:08:18,233 --> 01:08:19,866 -Somehow, she got herself the job 1228 01:08:19,900 --> 01:08:21,466 of writing a profile of him. 1229 01:08:21,500 --> 01:08:24,666 -And he gave an interview. 1230 01:08:24,700 --> 01:08:29,133 -And, unfortunately, she had her tape recorder running, 1231 01:08:29,166 --> 01:08:32,266 which, um, I doubt 1232 01:08:32,300 --> 01:08:35,066 my husband was aware of the fact that she had it running. 1233 01:08:35,100 --> 01:08:39,700 He said, "Why don't you come with me to the tennis game, 1234 01:08:39,733 --> 01:08:41,366 and we can talk in the car?" 1235 01:08:43,466 --> 01:08:45,933 -Yeah, I was trying to keep the girl amused 1236 01:08:45,966 --> 01:08:49,800 as I drove her back from watching me play tennis. 1237 01:08:49,833 --> 01:08:51,833 That's it. [ Laughs ] 1238 01:08:51,866 --> 01:08:55,966 So, what really concerned me was how my tennis was. 1239 01:08:58,066 --> 01:09:02,366 From the moment I read it, I knew I was in deep [bleep] 1240 01:09:02,400 --> 01:09:04,300 -It was picked up in the British press, 1241 01:09:04,333 --> 01:09:07,666 and then it just blew up in a few days. 1242 01:09:07,700 --> 01:09:10,166 -Well, you get into trouble. You can't control yourself. 1243 01:09:10,200 --> 01:09:11,833 I mean, but sometimes we don't know. 1244 01:09:11,866 --> 01:09:13,500 I mean, just take the race stuff that -- 1245 01:09:13,533 --> 01:09:14,833 Africa and Europe. -Yeah. 1246 01:09:14,866 --> 01:09:16,466 -The question still is how could someone as smart 1247 01:09:16,500 --> 01:09:19,033 as you are say what you did? 1248 01:09:19,066 --> 01:09:22,533 -Oh, I was saying something to a girl. 1249 01:09:22,566 --> 01:09:23,833 I never thought of her as a reporter. 1250 01:09:23,866 --> 01:09:25,366 She lived in our house for a year. 1251 01:09:25,400 --> 01:09:27,400 -Well, that doesn't make any difference. 1252 01:09:27,433 --> 01:09:29,733 -I was treating her like a daughter, and -- 1253 01:09:29,766 --> 01:09:31,166 -That doesn't make any difference, either. 1254 01:09:31,200 --> 01:09:34,033 Did you think the thought? 1255 01:09:34,066 --> 01:09:36,766 -Sure, I thought the thought, whether it was right or wrong. 1256 01:09:36,800 --> 01:09:39,400 I didn't think it appropriate ever to say it in public. 1257 01:09:39,433 --> 01:09:40,766 -Right. 1258 01:09:42,300 --> 01:09:46,000 -I never expected this woman who lived with us for a year 1259 01:09:46,033 --> 01:09:47,566 would write an article 1260 01:09:47,600 --> 01:09:52,700 which would make me despised by so many people. 1261 01:09:55,533 --> 01:09:57,133 I regret it. 1262 01:09:57,166 --> 01:10:02,333 I can't erase it by now saying I never meant what I said. 1263 01:10:07,100 --> 01:10:09,333 -I just -- We were devastated. 1264 01:10:09,366 --> 01:10:12,100 I really can't remember 'cause it was really bad. 1265 01:10:12,133 --> 01:10:13,400 That's all I can think of. 1266 01:10:13,433 --> 01:10:16,000 -Do you recognize it was off? -Oh, God, yes. 1267 01:10:16,033 --> 01:10:17,633 Instantly, I saw... 1268 01:10:20,300 --> 01:10:22,300 You know, this is the worst trouble ever in my life... 1269 01:10:22,333 --> 01:10:24,633 -Exactly. It was. -...because it hurt people, 1270 01:10:24,666 --> 01:10:26,733 and I didn't intend to hurt people, 1271 01:10:26,766 --> 01:10:30,666 and it implied that some people I work with 1272 01:10:30,700 --> 01:10:31,966 I have poor impressions of. 1273 01:10:32,000 --> 01:10:33,133 I don't. 1274 01:10:33,166 --> 01:10:35,833 -I had calls from Washington 1275 01:10:35,866 --> 01:10:38,066 that were saying, "Should Cold Spring Harbor 1276 01:10:38,100 --> 01:10:41,500 even be supported by public research grants 1277 01:10:41,533 --> 01:10:44,500 with somebody who has an attitude like that?" 1278 01:10:44,533 --> 01:10:47,833 My main concern at that time was making sure 1279 01:10:47,866 --> 01:10:50,966 that Cold Spring Harbor, the institution, in 2007 1280 01:10:51,000 --> 01:10:54,500 was not gonna be linked to statements which fundamentally, 1281 01:10:54,533 --> 01:10:58,566 I think, haven't been proven and are very, very controversial. 1282 01:10:58,600 --> 01:11:01,866 Part of the reason for that is the history of eugenics here, 1283 01:11:01,900 --> 01:11:06,466 going way back into the 1920s, 100 years ago. 1284 01:11:08,000 --> 01:11:11,033 I didn't want Cold Spring Harbor to get recast 1285 01:11:11,066 --> 01:11:15,533 in the era of the eugenics movement again. 1286 01:11:17,166 --> 01:11:20,533 -Early on in the history of Cold Spring, 1287 01:11:20,566 --> 01:11:24,166 a scientist named Charles Davenport 1288 01:11:24,200 --> 01:11:28,766 took over the leadership of the biological research there. 1289 01:11:28,800 --> 01:11:32,166 He believed in what was known as eugenics -- 1290 01:11:32,200 --> 01:11:37,033 that if you prevented certain people from having children 1291 01:11:37,066 --> 01:11:39,933 and promoted other people to have children 1292 01:11:39,966 --> 01:11:45,333 based on their genes, you could improve the human race. 1293 01:11:45,366 --> 01:11:47,400 Thousands and thousands and thousands of people 1294 01:11:47,433 --> 01:11:52,966 were sterilized because they were deemed unfit. 1295 01:11:53,000 --> 01:11:55,133 -By the 1930s, 1296 01:11:55,166 --> 01:11:58,266 the only people who were promoting it were Nazis. 1297 01:11:58,300 --> 01:11:59,600 They were awful! 1298 01:11:59,633 --> 01:12:03,433 -The Nazis in Germany were embracing eugenics 1299 01:12:03,466 --> 01:12:04,966 and promoting it. 1300 01:12:05,000 --> 01:12:08,666 They were celebrating the work of these American eugenicists. 1301 01:12:08,700 --> 01:12:10,133 But back in the United States, 1302 01:12:10,166 --> 01:12:13,600 people like Charles Davenport were on the outs. 1303 01:12:13,633 --> 01:12:15,600 Other scientists were realizing that it was 1304 01:12:15,633 --> 01:12:18,200 just a way of justifying racism. 1305 01:12:18,233 --> 01:12:23,200 All these old attitudes were being propped up 1306 01:12:23,233 --> 01:12:27,000 by a poor reading of genetics. 1307 01:12:27,033 --> 01:12:32,500 By the time that Watson arrives in Cold Spring in 1948, 1308 01:12:32,533 --> 01:12:37,866 this sordid history with eugenics is in the past. 1309 01:12:37,900 --> 01:12:43,100 -I was not in the slightest interested in eugenics, 1310 01:12:43,133 --> 01:12:46,366 nor was anyone there. 1311 01:12:46,400 --> 01:12:49,366 -The laboratory has been incredibly open, 1312 01:12:49,400 --> 01:12:52,600 putting all of this up on the web that was, 1313 01:12:52,633 --> 01:12:54,366 you know, under Jim's watch, 1314 01:12:54,400 --> 01:12:57,766 and, in fact, he and I have had this discussion -- 1315 01:12:57,800 --> 01:13:00,533 that, given the history of the laboratory and eugenics, 1316 01:13:00,566 --> 01:13:04,566 we can't revive this. 1317 01:13:07,533 --> 01:13:11,333 -They must have had board members come out 1318 01:13:11,366 --> 01:13:12,866 from New York to, 1319 01:13:12,900 --> 01:13:17,933 you know, decide whether he should be fired or not. 1320 01:13:17,966 --> 01:13:19,966 -There was some sentiment to ask him to, 1321 01:13:20,000 --> 01:13:22,466 you know, step down from the laboratory completely, 1322 01:13:22,500 --> 01:13:24,366 and I completely opposed that. 1323 01:13:24,400 --> 01:13:27,866 That was not even remotely on the radar screen for me. 1324 01:13:27,900 --> 01:13:32,300 -And the next day, Jim was fired without a lawyer or anything. 1325 01:13:32,333 --> 01:13:35,233 It was -- It was -- It was like a kangaroo court. 1326 01:13:35,266 --> 01:13:36,966 -We wanted to make it clear that Jim Watson 1327 01:13:37,000 --> 01:13:40,400 had no administrative role at the laboratory. 1328 01:13:40,433 --> 01:13:42,700 That did not mean that we fired him. 1329 01:13:42,733 --> 01:13:45,500 That meant that we made it explicit 1330 01:13:45,533 --> 01:13:48,866 that he had no administrative role. 1331 01:13:48,900 --> 01:13:53,000 I don't think what he said was defensible, 1332 01:13:53,033 --> 01:13:56,533 mainly the comment about African-American employees. 1333 01:13:56,566 --> 01:14:00,966 I wish he had, for lots of reasons 1334 01:14:01,000 --> 01:14:03,666 but mainly for his own reasons, 1335 01:14:03,700 --> 01:14:07,833 he would think a little bit more about what he says 1336 01:14:07,866 --> 01:14:12,566 because he has done so many amazing things in his life. 1337 01:14:12,600 --> 01:14:14,166 -That's fine. 1338 01:14:14,200 --> 01:14:17,900 -He called late yesterday to say he's back from Colorado. 1339 01:14:17,933 --> 01:14:20,400 -You know, Jim's still here. 1340 01:14:20,433 --> 01:14:22,833 He has still retained an office and an assistant, 1341 01:14:22,866 --> 01:14:27,733 and he plays a role as a scientist at the laboratory. 1342 01:14:27,766 --> 01:14:34,266 I think he is an extraordinarily valued person still... 1343 01:14:34,300 --> 01:14:37,233 despite some of the things that he said. 1344 01:14:37,266 --> 01:14:42,866 ## 1345 01:14:42,900 --> 01:14:50,100 -Given my desire never to stay away from messy problems, 1346 01:14:50,133 --> 01:14:53,466 I was bound to [bleep] myself sometime. 1347 01:14:53,500 --> 01:14:55,133 And that's what I did. 1348 01:14:57,700 --> 01:14:59,866 -Have your views on the relationship 1349 01:14:59,900 --> 01:15:02,233 between race and intelligence changed? 1350 01:15:02,266 --> 01:15:05,733 -No, not at all. I would like for them to change, 1351 01:15:05,766 --> 01:15:10,100 since there be new knowledge which, uh... 1352 01:15:10,133 --> 01:15:14,200 says that, uh, your... 1353 01:15:14,233 --> 01:15:19,266 nurture is much more important than nature. 1354 01:15:19,300 --> 01:15:21,566 But I haven't seen any knowledge, 1355 01:15:21,600 --> 01:15:24,833 and there's a difference, on the average, 1356 01:15:24,866 --> 01:15:27,500 between blacks and whites on IQ tests. 1357 01:15:27,533 --> 01:15:31,466 I would say the difference is, uh... 1358 01:15:35,066 --> 01:15:37,700 It's genetic. 1359 01:15:37,733 --> 01:15:40,033 -He's... 1360 01:15:40,066 --> 01:15:42,166 wrong, you know? 1361 01:15:42,200 --> 01:15:43,533 He's just wrong. 1362 01:15:43,566 --> 01:15:46,833 -Race is less a biological construct of humans 1363 01:15:46,866 --> 01:15:48,933 and more a social construct. 1364 01:15:48,966 --> 01:15:51,333 We know a great deal about human genetic variation 1365 01:15:51,366 --> 01:15:52,966 and how it's apportioned around the world. 1366 01:15:53,000 --> 01:15:55,033 There is absolutely no evidence 1367 01:15:55,066 --> 01:15:57,333 that there are genetic differences 1368 01:15:57,366 --> 01:16:01,966 that favor intelligence in any subpopulation of human beings -- 1369 01:16:02,000 --> 01:16:03,600 none whatsoever. 1370 01:16:03,633 --> 01:16:06,866 -I'm a product of the Roosevelt era. 1371 01:16:06,900 --> 01:16:12,133 And if you ask me what people thought 1372 01:16:12,166 --> 01:16:14,233 about race in the Roosevelt era, 1373 01:16:14,266 --> 01:16:17,900 we thought there were differences. 1374 01:16:17,933 --> 01:16:19,366 You know? 1375 01:16:19,400 --> 01:16:22,400 Thomas Jefferson thought there were differences. 1376 01:16:23,533 --> 01:16:33,000 ## 1377 01:16:33,033 --> 01:16:37,466 It should be no surprise that someone who wanted to find 1378 01:16:37,500 --> 01:16:41,333 the double helix believed that genes were important. 1379 01:16:44,566 --> 01:16:48,066 -Racism suspends all rational judgment. 1380 01:16:48,100 --> 01:16:49,433 It really does. 1381 01:16:49,466 --> 01:16:50,966 And it's one of the most insidious things 1382 01:16:51,000 --> 01:16:52,533 that racism does. 1383 01:16:52,566 --> 01:16:55,766 It takes people who are otherwise brilliant people 1384 01:16:55,800 --> 01:16:57,100 and gets them down roads 1385 01:16:57,133 --> 01:17:01,800 that are intellectually unsupportable. 1386 01:17:01,833 --> 01:17:06,033 -Jim's been called a racist, but a racist is someone 1387 01:17:06,066 --> 01:17:11,333 who makes the life of someone 1388 01:17:11,366 --> 01:17:19,033 who he has a strong feeling of dislike for miserable. 1389 01:17:19,066 --> 01:17:21,200 -The guy was clearly wrong, you know? 1390 01:17:21,233 --> 01:17:22,733 It's just -- 1391 01:17:22,766 --> 01:17:25,633 It's just fundamentally wrong to judge people by their race. 1392 01:17:25,666 --> 01:17:28,800 My point is that that's -- that's the -- 1393 01:17:28,833 --> 01:17:32,233 the antithesis of who he is -- 1394 01:17:32,266 --> 01:17:35,300 is actually a person who's extremely compassionate 1395 01:17:35,333 --> 01:17:37,766 and would look at people suffering from a disease 1396 01:17:37,800 --> 01:17:42,400 and say, "It doesn't matter what their religion is 1397 01:17:42,433 --> 01:17:44,633 or their ethnicity. 1398 01:17:44,666 --> 01:17:46,066 None of that really matters." 1399 01:17:46,100 --> 01:17:49,566 -What my dad doesn't understand is that because people 1400 01:17:49,600 --> 01:17:54,000 worship him and treat him like this living god, 1401 01:17:54,033 --> 01:17:56,000 that when you're in a position like that, 1402 01:17:56,033 --> 01:17:58,466 you have to be extra careful about what you say. 1403 01:17:58,500 --> 01:18:01,066 -He's been put on a pedestal 1404 01:18:01,100 --> 01:18:04,366 because of the significant impact that his -- 1405 01:18:04,400 --> 01:18:08,766 his science had and continues to have, 1406 01:18:08,800 --> 01:18:11,300 but the responsibility that comes with being 1407 01:18:11,333 --> 01:18:14,233 on that pedestal is not being met. 1408 01:18:14,266 --> 01:18:17,266 -I would actually thank him for his work 1409 01:18:17,300 --> 01:18:19,700 on the discovery of the structure for DNA, 1410 01:18:19,733 --> 01:18:22,566 and that should not be taken away from him, 1411 01:18:22,600 --> 01:18:25,866 despite the fact that he holds views that I would -- 1412 01:18:25,900 --> 01:18:29,133 social views that I feel are abhorrent. 1413 01:18:29,166 --> 01:18:34,700 -To the extent, uh, that, uh... 1414 01:18:34,733 --> 01:18:38,700 I have hurt people, of course I regret it, 1415 01:18:38,733 --> 01:18:42,633 and, you know, I like black people, 1416 01:18:42,666 --> 01:18:44,733 so why would I want to hurt them? 1417 01:18:44,766 --> 01:18:49,266 I don't know anyone who -- who takes any pleasure 1418 01:18:49,300 --> 01:18:52,366 on the differences between black and white 1419 01:18:52,400 --> 01:18:54,766 which didn't exist. 1420 01:18:54,800 --> 01:18:59,466 What? It's awful, just like it's awful for schizophrenics. 1421 01:18:59,500 --> 01:19:03,333 But if the difference exists, then we have to ask ourselves, 1422 01:19:03,366 --> 01:19:07,466 "How can we try and make it better?" 1423 01:19:07,500 --> 01:19:10,200 -I just don't -- I don't understand it. 1424 01:19:10,233 --> 01:19:12,800 It is very painful because I do love this man. 1425 01:19:12,833 --> 01:19:14,766 I mean, you have to love the teacher 1426 01:19:14,800 --> 01:19:17,633 who gave you your life in science. 1427 01:19:17,666 --> 01:19:21,466 I do love that person, you know, and you have to. 1428 01:19:21,500 --> 01:19:23,600 And I admire what he did for, you know, 1429 01:19:23,633 --> 01:19:25,333 creating a world of science 1430 01:19:25,366 --> 01:19:27,500 and creating the careers of all these people 1431 01:19:27,533 --> 01:19:31,333 who every one was privileged to have known such a person. 1432 01:19:31,366 --> 01:19:34,566 I don't know. It's tough. 1433 01:19:37,800 --> 01:19:41,533 -I guess what I think about is after my dad's died, 1434 01:19:41,566 --> 01:19:42,966 how will people judge him? 1435 01:19:43,000 --> 01:19:44,866 And... 1436 01:19:44,900 --> 01:19:48,700 this is sort of an anecdote, but I saw this video, 1437 01:19:48,733 --> 01:19:53,366 and it showed this albino orangutan with blue eyes. 1438 01:19:53,400 --> 01:19:54,733 It wasn't albino. 1439 01:19:54,766 --> 01:19:57,100 Whatever it is -- had white fur and blue eyes. 1440 01:19:57,133 --> 01:19:58,966 And it looked just like my dad. 1441 01:19:59,000 --> 01:20:01,133 And I thought, "Well, if this orangutan looks 1442 01:20:01,166 --> 01:20:03,600 just like my dad, what does this prove? 1443 01:20:03,633 --> 01:20:06,300 Does this prove that this orangutan is highly intelligent, 1444 01:20:06,333 --> 01:20:10,033 or does it prove that my dad's simply a monkey?" 1445 01:20:10,066 --> 01:20:13,900 And when I saw this video of this monkey looking like my dad, 1446 01:20:13,933 --> 01:20:15,966 I was like -- it was just weird, 1447 01:20:16,000 --> 01:20:18,966 because that's my position, that we're -- 1448 01:20:19,000 --> 01:20:22,433 you know, humans are all monkeys and we wear clothes 1449 01:20:22,466 --> 01:20:27,833 and we live in houses, but, you know, my dad's a monkey 1450 01:20:27,866 --> 01:20:29,466 that made the most of it, you know? 1451 01:20:29,500 --> 01:20:32,400 I-I -- That's the way I see it. 1452 01:20:32,433 --> 01:20:35,266 And he's just hoping he doesn't die a monkey death, 1453 01:20:35,300 --> 01:20:40,233 you know, falling on the forest floor and being ignored. 1454 01:20:40,266 --> 01:20:41,766 I don't know. 1455 01:20:41,800 --> 01:20:50,900 ## 1456 01:20:50,933 --> 01:20:55,400 -Rufus asked me how I wanted myself portrayed. 1457 01:20:55,433 --> 01:20:57,833 You know, what was a take-home lesson 1458 01:20:57,866 --> 01:21:00,033 after turning off the tube 1459 01:21:00,066 --> 01:21:02,833 and seeing me for a couple hours? 1460 01:21:06,133 --> 01:21:10,666 I said, "I just always wanted to be exceptional." 1461 01:21:10,700 --> 01:21:14,400 I think I have achieved that. 1462 01:21:14,433 --> 01:21:19,133 I want to be portrayed as someone who was concerned 1463 01:21:19,166 --> 01:21:20,866 for the world about me 1464 01:21:20,900 --> 01:21:25,466 as important as my concern for myself. 1465 01:21:29,366 --> 01:21:33,300 You know, now I really miss Crick. 1466 01:21:33,333 --> 01:21:38,700 I don't have anyone I can talk to now of Crick's intelligence. 1467 01:21:39,700 --> 01:21:42,000 Francis, do you think we were lucky to have solved it, 1468 01:21:42,033 --> 01:21:44,166 or was it real brainwork? 1469 01:21:44,200 --> 01:21:46,466 -Well, I guess we were certainly lucky. 1470 01:21:46,500 --> 01:21:48,633 We were lucky, I think, for two reasons. 1471 01:21:48,666 --> 01:21:51,400 We were thinking about the problem at the right time, 1472 01:21:51,433 --> 01:21:53,800 and then the two of us, by collaborating, 1473 01:21:53,833 --> 01:21:55,666 when one of us got on the wrong track, 1474 01:21:55,700 --> 01:21:57,866 the other one could get us out of it. 1475 01:21:57,900 --> 01:22:01,200 We weren't at least afraid of being very candid to each other, 1476 01:22:01,233 --> 01:22:04,333 to the point of being rude. 1477 01:22:04,366 --> 01:22:05,633 -You know, after I'm dead, 1478 01:22:05,666 --> 01:22:08,133 I'll be more famous than I am now 1479 01:22:08,166 --> 01:22:11,900 because DNA gets more famous. 1480 01:22:11,933 --> 01:22:14,466 DNA is not overrated. 1481 01:22:14,500 --> 01:22:16,233 [ Laughs ] You know? 1482 01:22:16,266 --> 01:22:18,266 Some -- Some things come and go. 1483 01:22:18,300 --> 01:22:20,233 Oh, DNA won't come and go. 1484 01:22:20,266 --> 01:22:25,233 ## 1485 01:22:25,633 --> 01:22:31,800 #### 1486 01:22:31,833 --> 01:22:38,033 ## 1487 01:22:38,066 --> 01:22:40,666 To order "Decoding Watson" 1488 01:22:38,066 --> 01:22:40,666 on \h DVD, 1489 01:22:40,700 --> 01:22:44,900 visit Shop PBS 1490 01:22:40,700 --> 01:22:44,900 or \h call 1-800-PLAY-PBS. 1491 01:22:44,933 --> 01:22:48,266 This program is also available 1492 01:22:44,933 --> 01:22:48,266 on \h Amazon Prime Video. 1493 01:22:48,300 --> 01:22:53,766 ## 1494 01:22:53,800 --> 01:22:56,166 Davis: I'm colored, Jewish, and Puerto Rican. 1495 01:22:56,200 --> 01:22:59,166 When I move into a neighborhood, I wipe it out. 1496 01:22:59,200 --> 01:23:00,700 Man: Sammy Davis Jr.'s whole life 1497 01:23:00,733 --> 01:23:02,133 was about confronting obstacles. 1498 01:23:02,166 --> 01:23:04,500 Davis: # Mr. Bojangles 1499 01:23:04,533 --> 01:23:06,133 # I gotta be 1500 01:23:06,166 --> 01:23:07,333 Man: But he had a vision for himself 1501 01:23:07,366 --> 01:23:08,733 that was bigger than white or black. 1502 01:23:08,766 --> 01:23:10,266 Davis: # Me! 1503 01:23:10,300 --> 01:23:14,166 Sammy Davis Jr., coming soon 1504 01:23:10,300 --> 01:23:14,166 to \h "American Masters." 1505 01:23:14,200 --> 01:23:21,666 ## 120021

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