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##
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-It's all for you.
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-Yes.
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-There he is --
the man of the hour!
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-How are you?
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-I'm fine.
-Great to see you!
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-Cheese.
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-You have to smile
for the cameras.
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-Happy birthday!
-How 'bout a good champagne?
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-I discovered DNA
through Jim Watson.
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I took a class from him,
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and after one hour,
that was it for me.
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-Nancy! [ Laughs ]
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-I think he changed many
people's lives that way.
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-Jim Watson changed my life!
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-He was clearly absolutely
brilliant and very eccentric.
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-Look.
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-Oh, Jim!
Mwah!
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-I had to be here
and look alive today.
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-He was a genius who discovered
the secret of life
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when he was 25 years old.
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It burst on the scene.
There it was.
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Bang.
Just there it was.
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-You could see it
would be revolutionary.
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And, of course, it was.
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-It's a discovery of a lifetime.
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-It's certainly one of the
greatest discoveries in science
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that's ever been made,
and in biology,
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it ranks up there
with Darwin and Mendel
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and then Watson and Crick.
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-Well, I wanted to do
something big.
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That's all. [ Chuckles ]
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-This is the kind of scientist
that people,
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in some ways,
dream about, right?
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Trying to discover something
that people care about,
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would have a lasting impact.
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There are sort of
not too many people
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that I can think of that
sort of had that moment.
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-The structure of DNA
was a monumental discovery.
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It would have been hard
for anyone,
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no matter how brilliant
they were,
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to do another thing
at that level.
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-It was even more important
than Darwin.
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-There are many
adjectives one could use
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to describe Jim Watson,
and "humble" is probably not
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the first to jump to your lips.
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##
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-He's kind of
the enfant terrible.
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-Jim is a radical.
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-He's an anarchist.
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-Rules are there to be broken.
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He's not afraid of that.
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-The rebel against
all standard thinking.
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-He was so innovative.
He had such vision.
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And he was so full
of intellectual energy and life.
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But he upset too many people.
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-You have gotten in trouble with
what you say and what you write.
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-Incredibly caustic,
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irresponsible things
about women,
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about African-Americans, about
whole categories of people.
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-I don't know whether simply
because you're the most
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candid person alive
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or whether you have
no edit function in your brain.
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-We've all heard the racist,
sexist, eugenicist, you name it.
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There's a risk to thinking
about genes all the time.
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-He loves throwing ideas
out there
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that provoke people
to push back against them.
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-Sometimes telling the truth
or just thinking the truth
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leads you into great difficulty,
like, you know, Plato
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or, particularly, Galileo.
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They gave him life imprisonment.
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-There are, you know, two sides,
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and one you clearly
can't understand,
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and the other embodies a person
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that you respect and interact
with for how they engage science
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and how they think
about a problem.
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And they can't be reconciled.
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-I think it's very hard
to reconcile all the parts.
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I don't think they really fit
together very well.
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And I think it's just part
of the bundle of things
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that make up
this complicated human being.
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-People are enigmas.
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We all are.
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Some of us are
just bigger enigmas
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in more different directions
than others.
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##
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##
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##
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-I've had this prejudice
since, you know,
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my 20s that genes
really are important.
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Oh, I think I'm a real
old-fashioned believer
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in the paramount role of genes
as opposed to environment.
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Genes -- they make you
what you are.
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##
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I want to be known as both
a writer and a scientist.
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I might even be a mathematician.
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Just some of my dreams.
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You know, I like to believe
that I've been successful
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for some of the genes
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that I probably shared
with my relative Orson Welles.
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-The DNA molecule might
very well turn out to be
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the most important discovery
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in the whole history
of medical science.
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Imagine the implications
to duplicate a human being
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genetically down
to the last detail.
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-"Citizen Kane" was sort of
the most famous movie ever made,
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you know, so the double helix
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was the most famous piece
of chemistry ever done.
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-Using physical
and chemical clues,
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scientists have been able
to figure out
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how the DNA molecule
looks in detail.
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-Well, gee.
What kind of stuff is DNA?
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-It's who you are.
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That very core of your being --
it's in your DNA.
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It's in your genes.
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If you're talking about
the molecule of life,
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it has to be able to do
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an incredible number
of things, right?
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It has to exist in every cell.
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It has to have enough diversity
that, from that information,
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you can create
an entire organism.
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And it also has to be able
replicate itself.
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So, understanding the structure
of the DNA molecule
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is really key to thinking about
how all of these properties
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can exist in a single molecule.
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-DNA is often called
a double helix.
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-It's two strands...
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-Kind of like a pair
of spiral staircases.
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-...like a twisting ladder.
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-Those are DNA's backbones.
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There's no information,
per se, in the backbone.
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What those backbones are
supporting in between them...
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-The rungs of the ladder...
-...that's what makes
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each of us
genetically distinct.
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-The whole of nature's
instructions are printed
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in these four chemical letters.
137
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-The rungs are called "bases,"
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which are these
little compounds...
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-There are four bases...
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-...adenine, cytosine,
guanine, and thymine.
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-...A, C, G, and T.
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-And they bond together
with hydrogen bonds.
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-A always pairs with T.
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C always pairs with G.
145
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-We have four different
puzzle pieces
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that you can arrange
in any number of ways.
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-If you change
the sequence of bases,
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that can change
the organism itself.
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If you take those two strands
and you pull them apart,
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you can rebuild a new second
strand on each one of those,
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and you will have
two identical copies
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of the original DNA molecule.
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-That tells you how
hereditary information
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is passed down
to the next generation.
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That's the central insight
of the double helix.
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##
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-I was born in Chicago
on April 6, 1928.
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I grew up on the South Side
of Chicago
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in a clean,
middle-class neighborhood.
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My mother was very social.
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She was a real social winner.
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Everyone liked her.
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She was unusually nice.
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My father was shy,
whereas I've never been shy.
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You know, sometimes
it's to the point
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of saying too much of the truth.
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My parents believed
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that you just had to
look after other people.
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They saw the solution to many
of our nation's problems
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should only be solved
by the government
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as opposed to business.
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My father had been
an amateur birdwatcher,
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a very obsessive one.
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Whenever there
were birds around,
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we went out together and walked.
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-Jim went to
the University of Chicago
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at age 16.
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He thought for a while he wanted
to be an ornithologist.
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-I thought probably I'll be
teaching birds
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in a school like Montana.
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I like Montana, so I wasn't
in any sense dreading
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what my life was going to be.
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Suddenly, I just saw
something else grip me more.
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00:10:32,933 --> 00:10:35,300
-Schroedinger was
a quantum physicist,
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and Schroedinger's book
asked the question,
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"What is a gene?"
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-That was a really big thing.
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That was maybe the biggest
of all questions.
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I read that
in the spring of '46.
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And I remember I said
"What Is Life?"
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was more interesting
than bird migrations."
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-Schroedinger basically
presented life
193
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as a question of physics.
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Physicists were very satisfied
with themselves by the 1930s,
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and they had every right to be.
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They had discovered particles
like electrons and protons.
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Physicists were able to unlock
the energy inside of atoms
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that you could see in nuclear
power and nuclear weapons.
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There were all these
amazing things that
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were happening
with quantum physics,
201
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and they really started
to feel like they were starting
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to find most of the forces and
the particles in the universe.
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And yet when they
looked over at life...
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[ Baby crying ]
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...they said, "Wait a minute.
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Like, we can't explain that."
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-This body -- what is it?
How did it begin?
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-The discovery of DNA itself
as the hereditary material
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00:12:04,200 --> 00:12:08,700
was not the discovery
of Watson and Crick.
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-About the time
that Darwin published
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"On the Origin of the Species,"
a Swiss-German scientist
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named Friedrich Miescher
was looking for a project,
213
00:12:17,966 --> 00:12:20,433
and his adviser said,
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"See if you can find out
anything about the nucleus."
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00:12:25,033 --> 00:12:27,966
Miescher went down to
the local hospital
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and got some bandages from
patients and scraped off the pus
217
00:12:35,233 --> 00:12:38,366
because that was a great
source of white blood cells
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00:12:38,400 --> 00:12:40,833
and each one of those
has a nucleus.
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So he had a little vial of
cell nuclei, ground them up,
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and did chemical tests on them.
221
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And he discovered in the cell
nucleus this new material.
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He didn't know what it was.
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He discovered DNA.
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But DNA is not yet thought of
as the material of genes.
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It's still pus on a bandage.
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00:13:04,433 --> 00:13:07,233
We knew by about 1910
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that genes were associated
with chromosomes.
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Chromosomes were known to
be made of DNA and protein.
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It wasn't clear which one was
the hereditary material.
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Protein is most of
the interesting stuff
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that goes on in your body --
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tissue, muscle,
blood, sinew, organs.
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00:13:33,500 --> 00:13:36,400
Around the turn of the century,
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a number of people studied
the biochemistry of DNA,
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found out that it has
these four subunits.
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Protein has 20 or more
different building blocks.
237
00:13:48,366 --> 00:13:51,133
So, it seemed obvious
that protein
238
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as a more complicated molecule,
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so, probably, it was
the material of the gene.
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00:13:57,066 --> 00:14:01,066
Then in 1944, out of left field
241
00:14:01,100 --> 00:14:04,700
came an experiment
that changed the game.
242
00:14:07,433 --> 00:14:10,800
-Avery, MacLeod, and McCarty
did an eloquent experiment
243
00:14:10,833 --> 00:14:12,633
with the bacterium
pneumococcus.
244
00:14:12,666 --> 00:14:15,333
-The bacteria that
caused pneumonia.
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00:14:15,366 --> 00:14:18,266
There were different strains
of the bacteria,
246
00:14:18,300 --> 00:14:20,433
and one of those strains
was virulent,
247
00:14:20,466 --> 00:14:22,466
meaning it caused the disease.
248
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Then you had another form
of the bacteria
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that was non-virulent.
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00:14:27,633 --> 00:14:31,066
-Oswald Avery showed that
you could convert
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the benign form
into the virulent form
252
00:14:34,233 --> 00:14:37,833
when the only thing
exchanged was DNA.
253
00:14:37,866 --> 00:14:41,000
-These bacteria --
when they divided,
254
00:14:41,033 --> 00:14:44,866
their descendants
could be killers, too.
255
00:14:44,900 --> 00:14:47,866
-This, therefore,
was definitive evidence
256
00:14:47,900 --> 00:14:51,366
that DNA was the molecule
of heredity.
257
00:14:51,400 --> 00:14:55,300
-So, experiments like
Avery's were making it clear
258
00:14:55,333 --> 00:15:01,266
that DNA was the stuff of genes,
but that alone didn't tell you
259
00:15:01,300 --> 00:15:03,066
how they stored
genetic information.
260
00:15:03,100 --> 00:15:05,400
They didn't even tell you
what DNA looked like.
261
00:15:07,533 --> 00:15:10,066
-The Cavendish laboratory
at Cambridge University
262
00:15:10,100 --> 00:15:14,366
was the most distinguished
laboratory for physics
263
00:15:14,400 --> 00:15:16,500
in the world.
264
00:15:16,533 --> 00:15:18,166
That's where Watson went.
265
00:15:22,400 --> 00:15:26,666
-Francis Crick was a physicist
who was turned biologist,
266
00:15:26,700 --> 00:15:31,833
and he just happened to be
in the same office with Watson,
267
00:15:31,866 --> 00:15:36,200
and they struck up
a conversation.
268
00:15:36,233 --> 00:15:40,866
-Francis was, you know, the most
intelligent person I met.
269
00:15:40,900 --> 00:15:43,233
And Crick would have
never focused on DNA
270
00:15:43,266 --> 00:15:45,533
if I hadn't been there.
271
00:15:45,566 --> 00:15:48,466
-Crick had done amazing work
in World War II,
272
00:15:48,500 --> 00:15:52,200
working with the military on
different kinds of technology.
273
00:15:52,233 --> 00:15:53,766
And so he was part of
that generation
274
00:15:53,800 --> 00:15:58,033
that was trying to get their
footing in the post-war world.
275
00:15:59,166 --> 00:16:02,466
-He was just this
larger-than-life personality,
276
00:16:02,500 --> 00:16:07,833
and, I think,
was a great foil to Jim
277
00:16:07,866 --> 00:16:10,800
in the sense that they
played off each other,
278
00:16:10,833 --> 00:16:15,033
but they understood each other
at the same time, immediately.
279
00:16:15,066 --> 00:16:17,500
It was like they could finish
each other's sentences, I think.
280
00:16:17,533 --> 00:16:20,833
-We liked each other.
281
00:16:20,866 --> 00:16:22,400
Yeah.
282
00:16:22,433 --> 00:16:25,900
You know, I didn't adore him or
anything like that, but, uh...
283
00:16:28,166 --> 00:16:30,400
I couldn't get enough of him.
284
00:16:32,533 --> 00:16:35,333
-Their relationship was driven
by mutual competition.
285
00:16:35,366 --> 00:16:37,333
They were always competing
against each other.
286
00:16:37,366 --> 00:16:39,900
And that was part of what
made them close friends.
287
00:16:39,933 --> 00:16:43,866
That was part of what made them
push so hard
288
00:16:43,900 --> 00:16:45,866
to get that structure.
289
00:16:50,700 --> 00:16:53,500
-Sometimes when you see
two names linked together,
290
00:16:53,533 --> 00:16:56,966
you know that one person
did all the work.
291
00:16:59,066 --> 00:17:02,533
But I think Watson and Crick
was -- you know, we were equal.
292
00:17:06,400 --> 00:17:07,866
-In the late 1960s,
293
00:17:07,900 --> 00:17:11,766
Watson decides that he wants
to tell his own personal story
294
00:17:11,800 --> 00:17:15,033
about discovering the structure
of DNA in 1953.
295
00:17:15,066 --> 00:17:16,333
-I mean, it was a great story.
296
00:17:16,366 --> 00:17:18,666
It would be nice
if we could write it up.
297
00:17:18,700 --> 00:17:21,433
I was relieved when Francis had
no intention
298
00:17:21,466 --> 00:17:24,433
of getting involved in it.
299
00:17:24,466 --> 00:17:27,866
And I guess you have to say
it was a chance
300
00:17:27,900 --> 00:17:32,100
to really show I was,
in some way...
301
00:17:32,133 --> 00:17:34,333
better than Francis.
302
00:17:34,366 --> 00:17:37,466
-"The Double Helix"
is kind of a prototype
303
00:17:37,500 --> 00:17:41,766
of telling the story
of how science really works,
304
00:17:41,800 --> 00:17:44,566
which was extremely
controversial at the time.
305
00:17:44,600 --> 00:17:50,600
##
306
00:17:50,633 --> 00:17:55,233
-Here was an account that was
actually exciting to read.
307
00:17:55,266 --> 00:17:57,733
With characters
and competitions and stories
308
00:17:57,766 --> 00:17:59,766
and bad guys and good guys.
309
00:17:59,800 --> 00:18:01,333
-There's a tremendous amount
of science
310
00:18:01,366 --> 00:18:06,733
packed into those 107 pages,
but he tells the science story
311
00:18:06,766 --> 00:18:11,233
by talking about
what was driving the people.
312
00:18:11,266 --> 00:18:14,733
-Science was usually portrayed
in a very gentlemanly way.
313
00:18:14,766 --> 00:18:16,466
You were polite
to your colleagues.
314
00:18:16,500 --> 00:18:17,900
You did not badmouth them.
315
00:18:17,933 --> 00:18:21,600
You never said that their ideas
were screwy.
316
00:18:21,633 --> 00:18:23,933
Watson said,
"It's not gentlemanly.
317
00:18:23,966 --> 00:18:27,166
It's rowdy, and it's fun,
and it's rude."
318
00:18:29,533 --> 00:18:31,533
-Generally, as soon as
I finished a chapter,
319
00:18:31,566 --> 00:18:34,600
I would always show it
to someone -- generally, a girl.
320
00:18:36,600 --> 00:18:39,166
-One day he had something
he wanted to show me,
321
00:18:39,200 --> 00:18:41,633
and it was a draft
of "The Double Helix."
322
00:18:41,666 --> 00:18:44,200
And he couldn't resist
looking to see what the reaction
323
00:18:44,233 --> 00:18:46,766
was gonna be
to these pretty outrageous --
324
00:18:46,800 --> 00:18:49,366
some of the outrageous
things he said.
325
00:18:49,400 --> 00:18:50,766
I thought, "Wow, this is
326
00:18:50,800 --> 00:18:52,133
the best science book
I've ever read," you know?
327
00:18:52,166 --> 00:18:55,600
I just thought it was
just thrilling.
328
00:18:55,633 --> 00:18:59,633
-"I have never seen
Francis Crick in a modest mood."
329
00:19:00,700 --> 00:19:02,866
The first sentence, I, you know,
330
00:19:02,900 --> 00:19:05,300
would say that was
the essence of the book.
331
00:19:05,333 --> 00:19:08,466
When I had the first sentence,
I had a point of view.
332
00:19:11,200 --> 00:19:13,100
-Rather than thinking of it
as you're looking
333
00:19:13,133 --> 00:19:17,600
through transparent glass window
into 1952-53,
334
00:19:17,633 --> 00:19:19,566
"this is the way it was,"
335
00:19:19,600 --> 00:19:22,566
think of it as looking through
glass darkly,
336
00:19:22,600 --> 00:19:24,333
through a distorting lens.
337
00:19:24,366 --> 00:19:28,833
You can't think of it
as a direct look into the past.
338
00:19:30,566 --> 00:19:32,633
-In many ways,
"The Double Helix"
339
00:19:32,666 --> 00:19:35,800
is a nonfiction novel.
340
00:19:35,833 --> 00:19:39,033
It tells a basically true story,
341
00:19:39,066 --> 00:19:41,933
but it fictionalizes
the characters,
342
00:19:41,966 --> 00:19:43,766
including Watson himself.
343
00:19:48,366 --> 00:19:52,800
-The outsider comes in,
shakes everybody up,
344
00:19:52,833 --> 00:19:55,200
and just shows them
how it's done.
345
00:19:57,733 --> 00:20:00,033
-I think Francis Crick,
the brilliant loudmouth
346
00:20:00,066 --> 00:20:01,500
who spends more time
347
00:20:01,533 --> 00:20:04,466
solving other people's problems
than doing his own.
348
00:20:04,500 --> 00:20:07,666
-He dominated any room
he was in.
349
00:20:08,966 --> 00:20:12,233
-Maurice Wilkins, a researcher
at King's College,
350
00:20:12,266 --> 00:20:13,900
was trying to use X-rays
351
00:20:13,933 --> 00:20:16,700
to figure out
the structure of DNA.
352
00:20:19,966 --> 00:20:23,766
He was very reserved,
very, very, very British.
353
00:20:23,800 --> 00:20:27,100
-Dr. Maurice Wilkins lives
with his family in Blackheath
354
00:20:27,133 --> 00:20:28,733
in South London.
355
00:20:28,766 --> 00:20:30,733
Dr. Wilkins,
what do you actually do?
356
00:20:30,766 --> 00:20:33,900
-The main thing in
my kind of scientific work
357
00:20:33,933 --> 00:20:36,300
is to be able to fiddle
with a thing,
358
00:20:36,333 --> 00:20:38,266
go on fiddling with it,
and fiddle, fiddle.
359
00:20:38,300 --> 00:20:40,966
-He's the kind of person
that you think
360
00:20:41,000 --> 00:20:45,333
would have been dabbling
around with this forever.
361
00:20:45,366 --> 00:20:48,033
-DNA belonged to Wilkins,
even though he wasn't
362
00:20:48,066 --> 00:20:51,333
necessarily making
any progress on it.
363
00:20:51,366 --> 00:20:54,500
-Maurice Wilkins was not
very effective, you know?
364
00:20:54,533 --> 00:20:57,633
He doesn't come out...
365
00:20:57,666 --> 00:20:59,800
good in the story.
366
00:20:59,833 --> 00:21:03,733
-At the time, Maurice was
working under a man
367
00:21:03,766 --> 00:21:05,233
called Randall.
368
00:21:05,266 --> 00:21:07,733
-John Randall,
the head of the lab...
369
00:21:07,766 --> 00:21:13,400
-Randall took the project away
from Maurice Wilkins.
370
00:21:13,433 --> 00:21:15,966
-The decision was to bring
in Rosalind Franklin
371
00:21:16,000 --> 00:21:21,600
to work on his project
with his student on his DNA.
372
00:21:21,633 --> 00:21:25,833
-Rosalind Franklin, in her 20s,
became a real master
373
00:21:25,866 --> 00:21:28,666
of X-ray crystallography --
to use X-rays
374
00:21:28,700 --> 00:21:32,666
to figure out the structures
of complicated molecules.
375
00:21:32,700 --> 00:21:34,100
Franklin was not a biologist,
376
00:21:34,133 --> 00:21:38,466
and she was very frank
about that.
377
00:21:38,500 --> 00:21:42,766
She did a lot of work
for years on coal,
378
00:21:42,800 --> 00:21:45,133
so she was actually
able to figure out
379
00:21:45,166 --> 00:21:47,833
the very complicated
structure of coal.
380
00:21:49,133 --> 00:21:52,566
Franklin got hired
with the understanding
381
00:21:52,600 --> 00:21:57,466
that she would be studying
the structure of DNA.
382
00:21:57,500 --> 00:22:00,600
Well, nobody told Wilkins.
383
00:22:00,633 --> 00:22:02,100
[ Laughs ]
384
00:22:02,133 --> 00:22:05,100
And nobody told Franklin
385
00:22:05,133 --> 00:22:08,233
that Wilkins
was already studying DNA.
386
00:22:08,266 --> 00:22:13,433
-I mean, that was unbelievable
that that happened.
387
00:22:13,466 --> 00:22:19,333
-He starts to treat her as if,
like, she's his assistant,
388
00:22:19,366 --> 00:22:22,366
and Rosalind Franklin
was not the sort of person
389
00:22:22,400 --> 00:22:24,433
to be treated as an assistant.
390
00:22:25,766 --> 00:22:30,100
She was very tough and wasn't
gonna take guff from anybody.
391
00:22:32,100 --> 00:22:35,300
And Wilkins clearly did not know
how to deal with a strong woman.
392
00:22:35,333 --> 00:22:37,266
-In "The Double Helix,"
she's represented
393
00:22:37,300 --> 00:22:40,900
in almost
an entirely negative light.
394
00:22:42,333 --> 00:22:45,766
Like, if this were a fairy tale,
she might be some kind
395
00:22:45,800 --> 00:22:48,300
of a witch who is holding on
to the treasure
396
00:22:48,333 --> 00:22:50,233
and she won't let it go.
397
00:22:50,266 --> 00:22:52,633
-Throughout the book,
he uses the name "Rosy"
398
00:22:52,666 --> 00:22:55,766
to refer to Rosalind Franklin.
399
00:22:55,800 --> 00:22:59,266
In her own biographies,
it is made very clear
400
00:22:59,300 --> 00:23:02,366
that she found
that name an insult.
401
00:23:02,400 --> 00:23:03,733
-He said if she had wanted to,
402
00:23:03,766 --> 00:23:07,133
she could have looked
really pretty, as though,
403
00:23:07,166 --> 00:23:09,533
number one, she should have,
and, number two, she didn't,
404
00:23:09,566 --> 00:23:12,233
and, number three, if she
really put effort into it,
405
00:23:12,266 --> 00:23:14,400
that's the thing
that's really important.
406
00:23:17,400 --> 00:23:20,300
-Outside the Franklin
that Watson knew,
407
00:23:20,333 --> 00:23:24,233
if you followed her
to one of her weekends in Paris,
408
00:23:24,266 --> 00:23:26,666
you would see
a very, very different woman.
409
00:23:30,633 --> 00:23:33,033
-The book was controversial
because of the way
410
00:23:33,066 --> 00:23:35,033
Jim wrote about people.
411
00:23:35,066 --> 00:23:36,933
There are a lot of passages
in the book
412
00:23:36,966 --> 00:23:38,833
that are just insulting.
413
00:23:38,866 --> 00:23:44,100
##
414
00:23:44,133 --> 00:23:47,533
He could have written a book
about his personal experiences
415
00:23:47,566 --> 00:23:49,733
in the discovery
of the structure of DNA
416
00:23:49,766 --> 00:23:52,300
without doing that to people
that he worked with.
417
00:23:52,333 --> 00:23:55,333
-I knew people would say,
"You can't tell.
418
00:23:55,366 --> 00:23:57,233
It'll upset people."
419
00:23:57,266 --> 00:23:59,400
Finally, it upset Francis.
420
00:23:59,433 --> 00:24:03,566
Then he objected
to the president of Harvard.
421
00:24:04,566 --> 00:24:07,233
-It was getting published
by Harvard University Press,
422
00:24:07,266 --> 00:24:09,433
and they wouldn't publish it,
423
00:24:09,466 --> 00:24:11,566
partly because they were
getting communications
424
00:24:11,600 --> 00:24:15,066
from Crick and Wilkins
saying, "Don't do this."
425
00:24:18,400 --> 00:24:21,433
-Francis wrote a letter
to the president of Harvard
426
00:24:21,466 --> 00:24:23,866
or told the head of the press,
427
00:24:23,900 --> 00:24:27,600
"I don't want to get between
two wild men."
428
00:24:27,633 --> 00:24:29,566
-Francis Crick wouldn't talk
to him for years
429
00:24:29,600 --> 00:24:31,233
after that came out.
430
00:24:33,400 --> 00:24:34,933
But it was a best seller.
431
00:24:37,000 --> 00:24:39,133
-It's on the list
of top 100 books
432
00:24:39,166 --> 00:24:41,800
in the American history
of literature.
433
00:24:41,833 --> 00:24:47,233
-And every history of DNA since
then starts with Watson's book.
434
00:24:52,033 --> 00:24:56,833
-Well, it takes all kinds
of scientists to make science.
435
00:24:56,866 --> 00:25:00,766
-Most scientists work
in a laboratory.
436
00:25:00,800 --> 00:25:02,000
It's like cooking.
437
00:25:02,033 --> 00:25:03,466
You know, you're
following recipes,
438
00:25:03,500 --> 00:25:06,133
and you're doing experiments,
and you get results,
439
00:25:06,166 --> 00:25:10,933
and you look at the results,
and that changes your thinking.
440
00:25:10,966 --> 00:25:14,200
Jim, on the other hand, used
the results of everybody else.
441
00:25:14,233 --> 00:25:17,033
-I was never really
a lab person.
442
00:25:19,833 --> 00:25:23,800
Francis said I was always off
working with my hands,
443
00:25:23,833 --> 00:25:25,400
and I suspect I am.
444
00:25:25,433 --> 00:25:29,333
I like to think about
other people's data.
445
00:25:30,133 --> 00:25:33,700
I found that there's actually
a role for people
446
00:25:33,733 --> 00:25:37,566
who just think about
other people's data.
447
00:25:37,600 --> 00:25:41,100
-"Impresario" is actually
a great word for Jim.
448
00:25:41,133 --> 00:25:44,733
-He created a vibrant department
of molecular biology at Harvard.
449
00:25:44,766 --> 00:25:46,766
-He liked having people
in his lab
450
00:25:46,800 --> 00:25:50,066
whom he could shape and mold.
451
00:25:50,100 --> 00:25:53,933
-It was a bunch of rag-tag,
kind of offbeat characters
452
00:25:53,966 --> 00:25:56,800
who came together
to make the science.
453
00:25:56,833 --> 00:25:59,233
-It was the beginning
of molecular biology,
454
00:25:59,266 --> 00:26:02,533
and it was a time
when nobody had been trained.
455
00:26:02,566 --> 00:26:06,533
We were the first people to be
trained as molecular biologists.
456
00:26:08,500 --> 00:26:12,566
-You knew when you heard him
that you were
457
00:26:12,600 --> 00:26:16,566
at the start of a revolution
in understanding,
458
00:26:16,600 --> 00:26:20,666
and you felt as if you were part
of this tiny group of people
459
00:26:20,700 --> 00:26:22,633
who had seen the light.
460
00:26:24,633 --> 00:26:28,133
[ Bell tolling ]
461
00:26:28,166 --> 00:26:30,500
-Until DNA came along,
462
00:26:30,533 --> 00:26:34,666
the big idea in biology
was evolution.
463
00:26:34,700 --> 00:26:36,700
What was the tree of life?
464
00:26:36,733 --> 00:26:40,200
How did it branch and so on?
465
00:26:40,233 --> 00:26:43,400
-He wanted to displace
these evolutionary biologists
466
00:26:43,433 --> 00:26:45,866
and replace them
with molecular biologists,
467
00:26:45,900 --> 00:26:48,333
so he was going into war.
468
00:26:48,366 --> 00:26:51,800
-Basically, evolution
was the top dog,
469
00:26:51,833 --> 00:26:55,566
and I went there and said,
"I'm the top dog."
470
00:26:55,600 --> 00:27:00,166
DNA was more important
than evolution.
471
00:27:00,200 --> 00:27:03,600
-He didn't care, I guess,
if people disliked him.
472
00:27:03,633 --> 00:27:06,766
He didn't care because
he knew he was right.
473
00:27:06,800 --> 00:27:09,600
If he had to upset somebody
to do it, well, so what?
474
00:27:09,633 --> 00:27:10,833
That didn't bother him at all.
475
00:27:10,866 --> 00:27:14,600
In fact, he kind of
got a kick out of it.
476
00:27:14,633 --> 00:27:15,966
-You can't go through life
477
00:27:16,000 --> 00:27:19,233
not making enemies
and accomplish great things.
478
00:27:19,266 --> 00:27:21,600
You have to have the courage
that something is better
479
00:27:21,633 --> 00:27:23,266
than something else.
480
00:27:26,200 --> 00:27:30,033
-When it was time to decide
which lab I should work in
481
00:27:30,066 --> 00:27:33,766
to do my thesis work,
I actually went along to
482
00:27:33,800 --> 00:27:37,300
a very famous professor
at Harvard
483
00:27:37,333 --> 00:27:40,200
and asked whether
I could work in his lab,
484
00:27:40,233 --> 00:27:43,266
and he looked at me
and said, "But you're a woman.
485
00:27:43,300 --> 00:27:45,333
You'll get married.
You'll have kids.
486
00:27:45,366 --> 00:27:46,966
What will be the good
of your having done
487
00:27:47,000 --> 00:27:48,800
a science degree then?"
488
00:27:48,833 --> 00:27:52,033
And I made it out of his office
before I burst into tears,
489
00:27:52,066 --> 00:27:56,200
and I went to my second
thesis adviser choice.
490
00:27:56,233 --> 00:27:59,766
-Joan came and said,
"Can I work for you?"
491
00:27:59,800 --> 00:28:03,266
And, uh, of course I said yes.
492
00:28:03,300 --> 00:28:06,633
-And it wasn't until several
months later that I realized
493
00:28:06,666 --> 00:28:09,366
I was the first woman
to whom he had ever said,
494
00:28:09,400 --> 00:28:12,466
yes, I could come be
a graduate student in his lab.
495
00:28:13,866 --> 00:28:16,800
-I myself wondered,
"Can women be scientists?
496
00:28:16,833 --> 00:28:18,233
There don't seem to be many."
497
00:28:18,266 --> 00:28:20,766
All these people winning
the Nobel Prize were men.
498
00:28:20,800 --> 00:28:22,633
And I think one of the things
that was so wonderful
499
00:28:22,666 --> 00:28:25,766
about Jim's support
for a young person --
500
00:28:25,800 --> 00:28:27,100
it didn't cross my mind --
501
00:28:27,133 --> 00:28:28,600
he never made me feel,
"Oh, you're a woman,
502
00:28:28,633 --> 00:28:29,833
and I don't know
if you can do this."
503
00:28:29,866 --> 00:28:31,200
He never made me feel that.
504
00:28:31,233 --> 00:28:32,966
If he was interested in you,
if he believed in you,
505
00:28:33,000 --> 00:28:36,733
if he thought you could do it,
then he supported you.
506
00:28:38,566 --> 00:28:42,933
-I always found women
made labs more interesting.
507
00:28:42,966 --> 00:28:46,133
I wanted as many women
as possible,
508
00:28:46,166 --> 00:28:49,166
you know, as long as
they were highly intelligent.
509
00:28:51,100 --> 00:28:53,500
-He confesses to have a penchant
for pretty girls,
510
00:28:53,533 --> 00:28:56,000
and he doesn't --
511
00:28:56,033 --> 00:28:59,200
he'll say it to anybody,
and he certainly said it to me,
512
00:28:59,233 --> 00:29:01,433
you know,
many, many, many times.
513
00:29:03,600 --> 00:29:04,933
-I think one forgets
514
00:29:04,966 --> 00:29:08,266
that this man was only
35 years old when I met him.
515
00:29:09,800 --> 00:29:12,200
For people of that age,
whether they're men or women,
516
00:29:12,233 --> 00:29:14,866
sex is certainly
on people's minds.
517
00:29:14,900 --> 00:29:18,000
-I knew I was gonna be
very famous,
518
00:29:18,033 --> 00:29:22,300
but it didn't necessarily mean
I'd ever get a girlfriend,
519
00:29:22,333 --> 00:29:26,266
and if you're an unmarried
young man,
520
00:29:26,300 --> 00:29:27,766
that's what you think about.
521
00:29:27,800 --> 00:29:28,966
You want a girlfriend.
522
00:29:29,000 --> 00:29:36,833
##
523
00:29:36,866 --> 00:29:40,166
-I worked for him in his office.
524
00:29:40,200 --> 00:29:43,433
I was actually a math major
at that time.
525
00:29:43,466 --> 00:29:46,400
I started in my sophomore year.
526
00:29:46,433 --> 00:29:50,500
I had just turned
18 that summer.
527
00:29:51,233 --> 00:29:54,566
There must have been something
really deep down that
528
00:29:54,600 --> 00:30:00,000
I couldn't have described
that made me like him.
529
00:30:00,033 --> 00:30:03,533
So, I made a mental note
at the end of the job interview
530
00:30:03,566 --> 00:30:05,500
that I would marry him.
531
00:30:06,433 --> 00:30:10,366
-We had one date
at the end of summer,
532
00:30:10,400 --> 00:30:14,966
and then I took her
to a sort of faculty party.
533
00:30:16,800 --> 00:30:18,366
Ask her.
534
00:30:18,400 --> 00:30:21,600
-At the end of the year,
he took me to a cocktail party,
535
00:30:21,633 --> 00:30:23,866
and -- I don't know --
I had gin and tonics.
536
00:30:23,900 --> 00:30:25,866
And then he walked me
back to the dorm,
537
00:30:25,900 --> 00:30:29,066
and I said, "Dr. Watson,
it was really fun
538
00:30:29,100 --> 00:30:31,966
working for you this year,"
and then he said to me,
539
00:30:32,000 --> 00:30:36,066
"Well, I hope you'll work
for me next year, too."
540
00:30:36,100 --> 00:30:41,233
So, that way,
I knew he liked me.
541
00:30:41,266 --> 00:30:45,733
But he didn't really know
how much I liked him.
542
00:30:45,766 --> 00:30:46,933
-You know, I didn't have
543
00:30:46,966 --> 00:30:49,833
a series
of 20 important girlfriends.
544
00:30:49,866 --> 00:30:52,800
I didn't have any important
girlfriend ever.
545
00:30:52,833 --> 00:30:57,866
And really never was with girls
very much until I married Liz.
546
00:31:00,200 --> 00:31:03,533
-People knew that he was looking
for a wife, I think.
547
00:31:03,566 --> 00:31:07,800
But we never saw any evidence
of a girlfriend.
548
00:31:07,833 --> 00:31:11,833
-It wasn't a very
public romance.
549
00:31:11,866 --> 00:31:16,133
-She was just 18,
and I was then 38.
550
00:31:16,166 --> 00:31:19,200
-So I think --
I don't just think it.
551
00:31:19,233 --> 00:31:20,666
I've heard Jim say it.
552
00:31:20,700 --> 00:31:22,500
It was unseemly.
553
00:31:22,533 --> 00:31:28,766
Our dates my junior year
consisted of a movie,
554
00:31:28,800 --> 00:31:32,066
a concert,
a cocktail party or two,
555
00:31:32,100 --> 00:31:34,033
and sharing the same bed.
556
00:31:34,066 --> 00:31:36,100
[ Laughs ]
557
00:31:36,133 --> 00:31:38,000
That's about it.
558
00:31:38,033 --> 00:31:39,766
-[ Grunts ]
559
00:31:39,800 --> 00:31:41,233
[ Grunts ]
560
00:31:44,266 --> 00:31:46,533
Oh!
561
00:31:46,566 --> 00:31:47,933
I'm too slow.
562
00:31:47,966 --> 00:31:49,200
-Yeah, you got to go
for the winner.
563
00:31:49,233 --> 00:31:52,200
That's what Dr. Watson
likes to do.
564
00:31:52,233 --> 00:31:54,900
-You have to go for winners
in science, too, you know?
565
00:31:54,933 --> 00:31:56,866
[ Chuckles ]
566
00:31:56,900 --> 00:32:02,100
##
567
00:32:02,133 --> 00:32:07,300
##
568
00:32:07,333 --> 00:32:10,233
-Linus Pauling was
this great chemist.
569
00:32:10,266 --> 00:32:12,666
Jim saw him as the competition.
570
00:32:17,433 --> 00:32:20,766
-In a sense, when you're working
on the same problem
571
00:32:20,800 --> 00:32:25,400
as someone else,
you're at war with each other.
572
00:32:25,433 --> 00:32:27,600
-Why did he want to find
out the structure of DNA?
573
00:32:27,633 --> 00:32:29,766
Is it to help humankind?
574
00:32:29,800 --> 00:32:31,866
Is it to advance
human knowledge?
575
00:32:31,900 --> 00:32:33,933
No, it's 'cause he wanted
to get it first.
576
00:32:33,966 --> 00:32:37,000
He wanted to beat Pauling.
577
00:32:37,033 --> 00:32:39,566
-Linus Pauling,
by the early 1950s,
578
00:32:39,600 --> 00:32:41,300
had already established himself
579
00:32:41,333 --> 00:32:44,500
as perhaps the finest chemist
in the world.
580
00:32:44,533 --> 00:32:47,833
-If we want to understand
the human body,
581
00:32:47,866 --> 00:32:50,266
we must know its structure.
582
00:32:50,300 --> 00:32:52,466
-I guess both of us
at that time --
583
00:32:52,500 --> 00:32:54,333
our thoughts were dominated
by Linus Pauling,
584
00:32:54,366 --> 00:32:58,333
a great chemist who was going
to solve biology, and --
585
00:32:58,366 --> 00:33:00,233
-Had you met Linus by this time?
586
00:33:00,266 --> 00:33:03,266
-He smiled at me.
-He smiled at you once?
587
00:33:07,033 --> 00:33:08,933
-The story to me was the race
with Pauling.
588
00:33:08,966 --> 00:33:11,833
Who was gonna win the race
with Pauling?
589
00:33:11,866 --> 00:33:17,000
-In "The Double Helix,"
Linus Pauling is Goliath...
590
00:33:17,033 --> 00:33:18,966
the lion in the room.
591
00:33:19,000 --> 00:33:22,266
[ Applause ]
592
00:33:22,300 --> 00:33:24,866
The dark-horse team
of Watson and Crick
593
00:33:24,900 --> 00:33:28,133
are going to try
to bring down the giant.
594
00:33:28,166 --> 00:33:31,533
Pauling didn't know that
he was racing against this guy.
595
00:33:31,566 --> 00:33:34,000
He probably didn't even know
who Jim was.
596
00:33:34,033 --> 00:33:35,366
-Well, one day,
597
00:33:35,400 --> 00:33:38,600
Watson gets the news
that he never wanted to hear.
598
00:33:38,633 --> 00:33:42,400
Linus Pauling had proposed
a structure for DNA.
599
00:33:42,433 --> 00:33:45,366
-Of course, we were upset.
-We were really on tenterhooks.
600
00:33:45,400 --> 00:33:48,533
-The question was,
could it be right?
601
00:33:48,566 --> 00:33:52,766
-Pauling was claiming that
it had three backbones.
602
00:33:52,800 --> 00:33:55,066
-A triple helix.
603
00:33:55,100 --> 00:33:57,600
-Three backbones --
that's wrong.
604
00:33:57,633 --> 00:34:00,733
-The structure was so awful.
605
00:34:00,766 --> 00:34:03,100
It was chemically impossible.
606
00:34:03,133 --> 00:34:04,433
[ Laughs ]
607
00:34:05,800 --> 00:34:07,633
-Very embarrassing
for the great Linus Pauling
608
00:34:07,666 --> 00:34:09,266
to make a rookie error,
609
00:34:09,300 --> 00:34:13,100
and so Watson thought as soon
as everybody starts pointing out
610
00:34:13,133 --> 00:34:16,000
to Pauling what a dumb
mistake he made,
611
00:34:16,033 --> 00:34:20,966
he would just go at the DNA
problem with everything he had
612
00:34:21,000 --> 00:34:23,066
and then he would crack it
'cause he's Linus Pauling.
613
00:34:23,100 --> 00:34:24,933
-The way Watson tells it,
614
00:34:24,966 --> 00:34:28,366
he had been down
to King's College London
615
00:34:28,400 --> 00:34:31,400
to tell Franklin and Wilkins,
616
00:34:31,433 --> 00:34:34,966
"Look, the great Linus Pauling
got it wrong!"
617
00:34:35,000 --> 00:34:36,500
-Linus wasn't gonna wait.
618
00:34:36,533 --> 00:34:39,533
Someone at Caltech was bound
to tell Linus he was wrong.
619
00:34:39,566 --> 00:34:45,666
-He had seen Franklin's lab door
open and gone in.
620
00:34:45,700 --> 00:34:52,133
##
621
00:34:52,166 --> 00:34:54,166
Franklin didn't like that.
622
00:34:54,200 --> 00:34:59,166
She was very private, and Watson
kind of barged in on her.
623
00:35:01,666 --> 00:35:03,566
She didn't like
the interruption.
624
00:35:08,133 --> 00:35:12,133
And the way he tells it,
he got a little cocky.
625
00:35:12,166 --> 00:35:19,033
##
626
00:35:19,066 --> 00:35:21,000
Franklin just blew up at him.
627
00:35:21,033 --> 00:35:24,666
-She came toward me, and I
thought she was going to hit me.
628
00:35:24,700 --> 00:35:27,300
I quickly got out, at which
point Maurice was coming around,
629
00:35:27,333 --> 00:35:29,000
and she almost hit Maurice.
630
00:35:30,766 --> 00:35:33,533
-Oh, God.
Who hit who?
631
00:35:33,566 --> 00:35:36,000
I don't think anybody
hit anybody, actually.
632
00:35:36,033 --> 00:35:39,266
Some people may have thought
someone was gonna hit somebody.
633
00:35:39,300 --> 00:35:42,500
-Wilkins and Watkins
were decompressing after that,
634
00:35:42,533 --> 00:35:44,500
both sort of panting
and sweating,
635
00:35:44,533 --> 00:35:48,000
and Wilkins said, "By the way,
I got something to show you."
636
00:35:48,033 --> 00:35:53,466
##
637
00:35:53,500 --> 00:35:55,533
-Maurice opened a drawer
and took out a photograph,
638
00:35:55,566 --> 00:35:57,466
and, boy, I could
hardly believe it.
639
00:35:59,500 --> 00:36:02,633
-Photograph 51 is quite
extraordinary.
640
00:36:02,666 --> 00:36:06,800
-This was the best X-ray
photograph of DNA ever taken.
641
00:36:06,833 --> 00:36:09,333
Wilkins couldn't take
X-ray pictures that good.
642
00:36:09,366 --> 00:36:10,933
He knew that.
643
00:36:10,966 --> 00:36:15,533
-Franklin was probably the only
person in the world good enough
644
00:36:15,566 --> 00:36:19,133
at what she did
to take those pictures.
645
00:36:19,166 --> 00:36:22,066
-Raymond Gosling,
who had worked with Franklin
646
00:36:22,100 --> 00:36:26,566
in creating the picture,
gave Wilkins that photograph.
647
00:36:29,033 --> 00:36:30,266
-An X-ray picture is not
648
00:36:30,300 --> 00:36:32,566
a simple picture
like a photograph.
649
00:36:32,600 --> 00:36:36,733
-You can't interpret it
just by looking at it.
650
00:36:36,766 --> 00:36:40,166
-When a X-ray
strikes the molecule,
651
00:36:40,200 --> 00:36:42,366
the waves of the X-rays
can squeeze
652
00:36:42,400 --> 00:36:45,033
in between the atoms,
and when they come out
653
00:36:45,066 --> 00:36:48,100
the other side,
their directions are deviated.
654
00:36:51,533 --> 00:36:54,366
-What it is is the pattern
of X-rays
655
00:36:54,400 --> 00:36:56,600
bouncing off the molecules.
656
00:36:59,433 --> 00:37:01,766
-You could tell there were
these two strands of DNA
657
00:37:01,800 --> 00:37:04,033
that are wound
around each other.
658
00:37:04,066 --> 00:37:06,933
That's what you can get
from X-ray crystallography.
659
00:37:06,966 --> 00:37:08,666
What you can't get
660
00:37:08,700 --> 00:37:13,366
is what's the chemistry
that's driving that structure.
661
00:37:16,533 --> 00:37:19,666
-Watson just sort of, like,
looked at Photograph 51
662
00:37:19,700 --> 00:37:22,700
and got an idea of the structure
that could explain it
663
00:37:22,733 --> 00:37:25,233
and then went off
and built a model.
664
00:37:25,266 --> 00:37:29,266
-Watson and Crick built models.
That was their approach.
665
00:37:29,300 --> 00:37:30,833
-I cut some things out
of cardboard,
666
00:37:30,866 --> 00:37:32,433
and so made the right shapes
667
00:37:32,466 --> 00:37:35,566
and pasted things on which
would indicate hydrogen atoms.
668
00:37:39,066 --> 00:37:41,933
-There's a lot of audacity
in saying,
669
00:37:41,966 --> 00:37:45,866
"This can be figured out
just by making models of it."
670
00:37:47,066 --> 00:37:48,133
-It was theory, you know,
671
00:37:48,166 --> 00:37:50,233
what might this
molecule be like?
672
00:37:50,266 --> 00:37:52,100
What kind of structure
might work?
673
00:37:52,133 --> 00:37:54,000
What would be plausible?
674
00:37:55,666 --> 00:37:58,533
-It's a hugely high-risk,
low-probability
675
00:37:58,566 --> 00:38:01,466
approach to science.
676
00:38:01,500 --> 00:38:05,033
-And Franklin just thought
this was ridiculous.
677
00:38:05,066 --> 00:38:06,900
-It's as if they were moving
towards the problem
678
00:38:06,933 --> 00:38:08,666
from different directions.
679
00:38:08,700 --> 00:38:12,266
-She felt that the data
had to speak for itself.
680
00:38:12,300 --> 00:38:16,266
She wanted to continue
making excellent measurements.
681
00:38:16,300 --> 00:38:18,100
-Picture after picture
after picture after picture,
682
00:38:18,133 --> 00:38:20,133
and then you sit down
and then you think about it
683
00:38:20,166 --> 00:38:23,300
and then you work out an idea
for the structure.
684
00:38:23,333 --> 00:38:25,100
She herself was getting
pretty close
685
00:38:25,133 --> 00:38:27,333
to figuring out
the structure of DNA.
686
00:38:27,366 --> 00:38:30,900
-But she's not gonna publish
anything until, like,
687
00:38:30,933 --> 00:38:32,933
it's ready
to take it to the bank.
688
00:38:32,966 --> 00:38:34,200
-You know, Rosalind Franklin
689
00:38:34,233 --> 00:38:37,333
had that famous photograph
for eight months
690
00:38:37,366 --> 00:38:40,033
and never concluded it
was the helix.
691
00:38:42,133 --> 00:38:43,433
You know...
692
00:38:43,466 --> 00:38:45,300
it's just stupid!
693
00:38:45,333 --> 00:38:47,766
-She was very devoted
to hard evidence.
694
00:38:47,800 --> 00:38:49,666
She didn't want to make
any claim
695
00:38:49,700 --> 00:38:51,800
for anything
without hard evidence.
696
00:38:51,833 --> 00:38:55,433
And part of that may be because
she was a female scientist.
697
00:38:57,333 --> 00:39:00,800
-This idea of having to hold
so close the work
698
00:39:00,833 --> 00:39:03,500
that you're doing
and the scrutiny
699
00:39:03,533 --> 00:39:07,033
that it might get
since you are female --
700
00:39:07,066 --> 00:39:08,433
I could relate to this idea
701
00:39:08,466 --> 00:39:11,400
that I'm gonna keep
everything very close
702
00:39:11,433 --> 00:39:13,866
until it can be checked
a thousand times over
703
00:39:13,900 --> 00:39:16,500
before I share it.
704
00:39:16,533 --> 00:39:18,566
-I think we all know
that if you're from
705
00:39:18,600 --> 00:39:21,733
a marginalized group
and you make a mistake,
706
00:39:21,766 --> 00:39:23,300
that could be the end
of your career,
707
00:39:23,333 --> 00:39:26,300
whereas, you know, if you're
from a privileged group
708
00:39:26,333 --> 00:39:29,033
and you make a mistake, "Eh."
709
00:39:29,066 --> 00:39:31,633
-Well...
710
00:39:31,666 --> 00:39:34,866
she -- she just botched it.
711
00:39:34,900 --> 00:39:37,366
She basically threw me
out of her office
712
00:39:37,400 --> 00:39:40,700
when I said DNA is a helix.
713
00:39:40,733 --> 00:39:44,933
So, you know, she was --
714
00:39:44,966 --> 00:39:46,733
she was pig-headed.
715
00:39:48,133 --> 00:39:51,233
-She had this gorgeous data,
a beautiful,
716
00:39:51,266 --> 00:39:57,433
essential piece of data,
but she was, um, isolated.
717
00:40:00,466 --> 00:40:01,833
-The men obviously had a network
718
00:40:01,866 --> 00:40:04,700
because it was
a men's kind of job.
719
00:40:06,300 --> 00:40:09,133
The men were free to interact,
to listen,
720
00:40:09,166 --> 00:40:11,000
and they were
in their boys' club,
721
00:40:11,033 --> 00:40:13,166
and without that,
nothing would have happened.
722
00:40:13,200 --> 00:40:16,100
-They talk about the discussions
over lunch every day...
723
00:40:16,133 --> 00:40:17,366
-I remember this conversation
724
00:40:17,400 --> 00:40:19,366
was in the dining room
of our house.
725
00:40:19,400 --> 00:40:20,700
We were sitting in a pub.
726
00:40:20,733 --> 00:40:24,033
-...you know, walking
to play tennis.
727
00:40:24,066 --> 00:40:27,366
-I met him a little later in
the tea queue at the Cavendish.
728
00:40:27,400 --> 00:40:30,333
-And so if you're not part
of those discussions,
729
00:40:30,366 --> 00:40:32,766
it makes it a lot harder.
730
00:40:32,800 --> 00:40:34,700
-Watson's great strength
was his ability
731
00:40:34,733 --> 00:40:40,733
to synthesize the various
observations surrounding DNA
732
00:40:40,766 --> 00:40:43,666
such that he could work out
the structure of DNA.
733
00:40:43,700 --> 00:40:49,266
-And the next morning, I came in
and started playing with models,
734
00:40:49,300 --> 00:40:52,366
and then I discovered
that you could put adenine
735
00:40:52,400 --> 00:40:54,933
and thymine together
in exactly the same way
736
00:40:54,966 --> 00:40:56,966
you could put guanine
and cytosine together.
737
00:40:57,000 --> 00:40:59,933
-Jim realized that the shape
of an A-T base pair
738
00:40:59,966 --> 00:41:03,533
and a G-C base pair
was exactly the same.
739
00:41:03,566 --> 00:41:06,233
-Everything from then
on was clear.
740
00:41:06,266 --> 00:41:12,566
##
741
00:41:12,600 --> 00:41:18,933
##
742
00:41:18,966 --> 00:41:22,300
-February 28, 1953,
is the day
743
00:41:22,333 --> 00:41:25,700
that they solved the structure
of the double helix.
744
00:41:29,733 --> 00:41:32,466
-Crick was famous for walking
into the Eagle bar and saying,
745
00:41:32,500 --> 00:41:34,500
"We've discovered
the secret of life!"
746
00:41:38,033 --> 00:41:40,200
-We used to occasionally,
just Jim and I,
747
00:41:40,233 --> 00:41:43,333
just sit
and look at the molecule
748
00:41:43,366 --> 00:41:45,966
and think how beautiful it was.
749
00:41:46,000 --> 00:41:49,533
And I remember an occasion
when Jim gave a talk
750
00:41:49,566 --> 00:41:51,133
to a little bar physics club
we had.
751
00:41:51,166 --> 00:41:54,066
It's true they gave him one
or two drinks before dinner.
752
00:41:54,100 --> 00:41:56,233
It was rather a short talk
because all he could say
753
00:41:56,266 --> 00:41:59,200
at the end was,
"Well, you see, it's so pretty.
754
00:41:59,233 --> 00:42:00,466
It's so pretty."
755
00:42:02,933 --> 00:42:04,866
-You see a lot of stuff
about the Nobel Prize
756
00:42:04,900 --> 00:42:07,866
and rivalry with Pauling
in "The Double Helix."
757
00:42:07,900 --> 00:42:11,266
I actually think
their motivation was purer than
758
00:42:11,300 --> 00:42:12,900
is actually portrayed.
759
00:42:12,933 --> 00:42:14,400
I think they were thinking,
760
00:42:14,433 --> 00:42:18,566
"We've got an intuition about
what's important in biology,
761
00:42:18,600 --> 00:42:20,033
and we're gonna carry
that forward."
762
00:42:20,066 --> 00:42:22,433
I don't think they were
thinking, "Nobel Prize."
763
00:42:22,466 --> 00:42:25,333
-I think you could say
within five seconds
764
00:42:25,366 --> 00:42:28,700
we knew we should have
a Nobel Prize.
765
00:42:28,733 --> 00:42:32,700
Well, we got the Nobel Prize
in 1962,
766
00:42:32,733 --> 00:42:37,800
so that was nine years
after the discovery.
767
00:42:37,833 --> 00:42:43,066
It was Francis and I
and Maurice Wilkins.
768
00:42:43,100 --> 00:42:45,266
And you could say,
"Well, what did he do
769
00:42:45,300 --> 00:42:47,233
to deserve a Nobel Prize?"
770
00:42:48,533 --> 00:42:50,700
But, in fact,
we couldn't have done it
771
00:42:50,733 --> 00:42:53,066
if Wilkins hadn't started it.
772
00:42:54,866 --> 00:43:01,366
-Maybe had there been more of
a collaborative environment,
773
00:43:01,400 --> 00:43:06,766
then everyone might have made it
to the finish line together.
774
00:43:06,800 --> 00:43:08,266
-Rosalind was bright.
775
00:43:08,300 --> 00:43:12,766
She had all the intelligence
you need to solve the problem.
776
00:43:12,800 --> 00:43:17,166
She just didn't
make friends easy.
777
00:43:17,200 --> 00:43:22,800
-If she had had a real friend
who was intelligent,
778
00:43:22,833 --> 00:43:25,100
they would have
probably told her
779
00:43:25,133 --> 00:43:28,766
on a couple of occasions,
"You're an ass."
780
00:43:28,800 --> 00:43:35,466
-Later, much later,
the myth had arisen that
781
00:43:35,500 --> 00:43:41,500
Jim Watson and Francis Crick
had stolen her work,
782
00:43:41,533 --> 00:43:45,033
which is basically nonsense.
783
00:43:45,066 --> 00:43:47,733
-Watson did not break in
to Franklin's office
784
00:43:47,766 --> 00:43:49,666
and pilfer photographs.
785
00:43:49,700 --> 00:43:51,500
-Wilkins showed it to Watson
786
00:43:51,533 --> 00:43:55,133
without Rosalind Franklin's
knowledge.
787
00:43:55,166 --> 00:43:58,266
-Wilkins showed it to me
'cause he was so frustrated
788
00:43:58,300 --> 00:44:03,133
that Rosalind wasn't
following up her X-ray picture.
789
00:44:03,166 --> 00:44:05,733
You shouldn't look at it
until you get permission,
790
00:44:05,766 --> 00:44:08,400
but you can't see something
791
00:44:08,433 --> 00:44:11,466
so potentially exciting
without thinking about it.
792
00:44:11,500 --> 00:44:14,000
I would just say that's
against human nature.
793
00:44:14,033 --> 00:44:16,600
-He didn't steal it, you know,
but he didn't acknowledge it.
794
00:44:16,633 --> 00:44:18,100
That's the point.
795
00:44:18,133 --> 00:44:20,966
I mean, normally in science, you
acknowledge the data you get.
796
00:44:21,000 --> 00:44:24,366
And probably he should have
contacted her and asked, right,
797
00:44:24,400 --> 00:44:26,466
"Are you happy if we use it?"
798
00:44:26,500 --> 00:44:29,200
This is clearly unethical
behavior in science.
799
00:44:29,233 --> 00:44:31,800
-By modern scientific standards,
we would have actually
800
00:44:31,833 --> 00:44:35,733
considered this an example
of scientific malfeasance.
801
00:44:35,766 --> 00:44:37,800
Showing another scientist's data
without their permission
802
00:44:37,833 --> 00:44:39,600
is not something
that's allowed today.
803
00:44:39,633 --> 00:44:43,433
But in that climate,
under those circumstances,
804
00:44:43,466 --> 00:44:45,266
it wasn't considered that.
805
00:44:45,300 --> 00:44:47,833
-When a woman made
a scientific discovery,
806
00:44:47,866 --> 00:44:51,066
it often was
not credited to her.
807
00:44:51,100 --> 00:44:54,666
She wasn't valued in the same
way that men were who made that.
808
00:44:54,700 --> 00:44:57,366
Women's scientific discoveries
809
00:44:57,400 --> 00:44:58,966
didn't even belong
to them, really.
810
00:44:59,000 --> 00:45:01,733
They were just there
for the taking.
811
00:45:01,766 --> 00:45:03,466
They belonged to the air.
812
00:45:05,700 --> 00:45:08,266
-If we didn't exist,
then she would be
813
00:45:08,300 --> 00:45:12,133
the most famous woman scientist
ever to live.
814
00:45:12,166 --> 00:45:16,600
So, that's a big loss
that women don't have her.
815
00:45:16,633 --> 00:45:19,233
-Of course, the greatest
tragedy of why
816
00:45:19,266 --> 00:45:21,500
she couldn't have been nominated
for the Nobel Prize
817
00:45:21,533 --> 00:45:26,166
was the fact that she died
before the structure of DNA
818
00:45:26,200 --> 00:45:28,366
was considered
for a Nobel Prize.
819
00:45:30,600 --> 00:45:34,133
-She died of cancer
at a very young age,
820
00:45:34,166 --> 00:45:36,300
well before they got
the Nobel Prize,
821
00:45:36,333 --> 00:45:39,866
and probably died in part
because of the science
822
00:45:39,900 --> 00:45:43,866
she was doing that involved
X-rays and radiation.
823
00:45:48,866 --> 00:45:52,966
-Jim used to say science
is a young person's game.
824
00:45:53,000 --> 00:45:57,466
And, you know, he discovered the
double helix at the age of 25,
825
00:45:57,500 --> 00:45:59,433
won the Nobel Prize
at a very young age,
826
00:45:59,466 --> 00:46:01,733
and most people would have
sat on their laurels.
827
00:46:01,766 --> 00:46:03,400
Jim didn't.
828
00:46:05,500 --> 00:46:09,433
He came here because I think
he wanted to run his own shop,
829
00:46:09,466 --> 00:46:11,266
if you will
830
00:46:11,300 --> 00:46:14,900
and have a direction
and an influence.
831
00:46:14,933 --> 00:46:17,566
-I think except when
I'm playing tennis.
832
00:46:17,600 --> 00:46:21,000
I spend my whole life thinking.
833
00:46:21,033 --> 00:46:22,666
That's all I want to do.
834
00:46:24,766 --> 00:46:28,533
-This is a place where
you can set the stage
835
00:46:28,566 --> 00:46:31,400
for what's going on in science.
836
00:46:31,433 --> 00:46:37,466
-My own desire was
to understand cancer viruses
837
00:46:37,500 --> 00:46:41,033
and then probably
understanding cancer genes
838
00:46:41,066 --> 00:46:43,200
as fast as possible.
839
00:46:43,233 --> 00:46:46,566
I had seen my father's younger
brother die of melanoma,
840
00:46:46,600 --> 00:46:50,133
and, you know, it's awful.
841
00:46:50,166 --> 00:46:52,266
Oh, Matt, we shouldn't
have waited
842
00:46:52,300 --> 00:46:54,033
till the drug gets approval.
843
00:46:54,066 --> 00:46:56,966
You know, that could be
another year from now.
844
00:46:57,000 --> 00:47:02,700
And I have a self-interest
in trying to explain to them
845
00:47:02,733 --> 00:47:05,933
that, you know, I'm still alive.
846
00:47:05,966 --> 00:47:08,833
Even though I will soon be 90,
847
00:47:08,866 --> 00:47:12,733
I'm trying to be
at the frontier.
848
00:47:14,233 --> 00:47:18,300
-Jim was one of the scientists,
very prominent scientists --
849
00:47:18,333 --> 00:47:19,900
he had already
won a Nobel Prize --
850
00:47:19,933 --> 00:47:22,500
who was working on
trying to influence Congress
851
00:47:22,533 --> 00:47:24,066
but particularly the president
852
00:47:24,100 --> 00:47:27,700
on putting much
more funding into cancer...
853
00:47:27,733 --> 00:47:30,166
-We are here today
for the purpose of signing
854
00:47:30,200 --> 00:47:32,600
the Cancer Act of 1971.
855
00:47:32,633 --> 00:47:35,266
-...now known as the so-called
"war on cancer."
856
00:47:35,300 --> 00:47:37,066
-We don't have to tell
House and Senate members
857
00:47:37,100 --> 00:47:38,333
how to get in the picture.
858
00:47:38,366 --> 00:47:39,766
[ Laughter ]
859
00:47:39,800 --> 00:47:40,900
-To my amazement,
all of a sudden,
860
00:47:40,933 --> 00:47:42,366
Jim was going to start
a whole lab
861
00:47:42,400 --> 00:47:45,233
devoted to understanding cancer
at the molecular level.
862
00:47:45,266 --> 00:47:49,100
-Even before the DNA structure,
I was conscious that, probably,
863
00:47:49,133 --> 00:47:52,800
cancer was a genetic disease
that ran in families,
864
00:47:52,833 --> 00:47:58,966
so I thought cancer would be
understood through DNA analysis.
865
00:47:59,000 --> 00:48:01,266
-And he needed more resources
than he could get at Harvard,
866
00:48:01,300 --> 00:48:04,433
so he was gonna go
to Cold Spring Harbor.
867
00:48:06,633 --> 00:48:09,066
-You know, I've always loved
Cold Spring Harbor.
868
00:48:11,566 --> 00:48:13,966
I had come here at the end
of my first year
869
00:48:14,000 --> 00:48:17,900
of graduate school,
and I was 20 years old.
870
00:48:20,166 --> 00:48:24,266
It had been the first place
for genetics
871
00:48:24,300 --> 00:48:25,933
in the United States.
872
00:48:28,266 --> 00:48:30,566
-Cold Spring Harbor Laboratory
was founded in 1890,
873
00:48:30,600 --> 00:48:35,066
and for 60 years, it was funded
by Andrew Carnegie's foundation.
874
00:48:35,100 --> 00:48:37,400
Huge, important work done here.
875
00:48:40,966 --> 00:48:43,533
But when the Carnegie Foundation
pulled out,
876
00:48:43,566 --> 00:48:45,033
the laboratory
was almost broken.
877
00:48:45,066 --> 00:48:48,000
In fact, almost closed.
878
00:48:48,033 --> 00:48:52,200
-The plumbing didn't work.
The lawns were overgrown.
879
00:48:52,233 --> 00:48:53,866
The paint was peeling.
880
00:48:53,900 --> 00:48:56,433
It was on the verge
of bankruptcy.
881
00:48:56,466 --> 00:49:02,500
-When it began to fail,
I didn't want to see it fail.
882
00:49:02,533 --> 00:49:05,533
-One of Jim Watson's goals
has been the directorship
883
00:49:05,566 --> 00:49:08,300
of the Cold Spring Harbor
Biological Laboratories
884
00:49:08,333 --> 00:49:09,866
on Long Island.
885
00:49:09,900 --> 00:49:12,100
-Jim took over the lab.
886
00:49:12,133 --> 00:49:18,366
In November of 1967,
hubby-pie Watson
887
00:49:18,400 --> 00:49:21,800
brought me to Cold Spring Harbor
on our honeymoon.
888
00:49:23,800 --> 00:49:27,166
He said he would run
Cold Spring Harbor Lab
889
00:49:27,200 --> 00:49:29,433
for three years,
and if he hadn't built up
890
00:49:29,466 --> 00:49:33,233
an endowment for the lab,
he'd just go back to Harvard.
891
00:49:33,266 --> 00:49:37,466
-He started courting the
neighbors and getting donations.
892
00:49:37,500 --> 00:49:40,600
He is actually pretty good
at currying favor
893
00:49:40,633 --> 00:49:43,366
with rich people
and powerful people.
894
00:49:43,400 --> 00:49:48,466
He learned to be a little odd,
to say funny things,
895
00:49:48,500 --> 00:49:51,466
and they like him better.
896
00:49:51,500 --> 00:49:56,066
There's this piece of Watson
lore that everybody knows.
897
00:49:56,100 --> 00:49:59,133
-That he sometimes purposefully
untied his shoes
898
00:49:59,166 --> 00:50:00,566
before he entered a room.
899
00:50:00,600 --> 00:50:02,433
-Before he'd go in,
he would stop
900
00:50:02,466 --> 00:50:06,566
and mess up his hair
and untie his shoelaces.
901
00:50:06,600 --> 00:50:08,100
-The untied shoelaces.
902
00:50:08,133 --> 00:50:10,633
-He'll deliberately untie
his shoes and mess up his hair
903
00:50:10,666 --> 00:50:13,633
so he's the stereotypical
mad scientist
904
00:50:13,666 --> 00:50:14,900
as he goes to meet with them.
905
00:50:14,933 --> 00:50:17,666
-To give them what
they were paying for.
906
00:50:17,700 --> 00:50:20,700
-He wouldn't do it on purpose.
907
00:50:20,733 --> 00:50:23,733
You know, he's an
absent-minded scientist.
908
00:50:23,766 --> 00:50:26,633
I imagine it's in his DNA.
909
00:50:26,666 --> 00:50:29,466
-Jim stormed in
to Cold Spring Harbor
910
00:50:29,500 --> 00:50:34,000
and went to work
with unbelievable energy.
911
00:50:37,766 --> 00:50:41,700
Suddenly, it was vibrant.
It was growing.
912
00:50:41,733 --> 00:50:44,166
-Under his leadership,
Cold Spring Harbor became
913
00:50:44,200 --> 00:50:50,166
a focus for molecular genetic
research at a world level.
914
00:50:50,200 --> 00:50:52,000
-I was giving my job
interview here,
915
00:50:52,033 --> 00:50:55,566
and, at some point,
I realize there's somebody
916
00:50:55,600 --> 00:50:58,766
yawning extremely loudly
in the first row...
917
00:50:58,800 --> 00:51:01,066
[ Yawns ]
918
00:51:01,100 --> 00:51:03,000
...throughout my talk.
919
00:51:03,033 --> 00:51:05,633
And so I realize,
"Oh, this is Jim."
920
00:51:05,666 --> 00:51:08,233
He was trying to say that,
"You know, this cancer stuff
921
00:51:08,266 --> 00:51:10,800
that you're presenting
is so boring.
922
00:51:10,833 --> 00:51:15,766
Give me something that actually
matters and makes a difference."
923
00:51:15,800 --> 00:51:17,800
-There are very few institutions
in the world
924
00:51:17,833 --> 00:51:20,466
that have such a big influence.
925
00:51:20,500 --> 00:51:23,200
I mean, we've got DNA money
sent to us in Singapore
926
00:51:23,233 --> 00:51:28,266
and China and Vienna
and around the United States.
927
00:51:28,300 --> 00:51:29,533
You know,
just on Long Island alone,
928
00:51:29,566 --> 00:51:32,366
we educate 32,000 kids a year.
929
00:51:32,400 --> 00:51:35,300
-In our school, we had the
Meeting of the Minds Project...
930
00:51:35,333 --> 00:51:36,866
-Yeah.
-...which is basically where
931
00:51:36,900 --> 00:51:38,400
people dress up as someone.
932
00:51:38,433 --> 00:51:41,300
Like, my brother did Beethoven,
and I did you.
933
00:51:41,333 --> 00:51:44,333
-Oh. We should get
a picture together.
934
00:51:46,500 --> 00:51:47,933
Say, "DNA."
935
00:51:47,966 --> 00:51:49,200
-DNA!
936
00:51:49,233 --> 00:51:50,633
# I got, I got, I got
937
00:51:50,666 --> 00:51:54,033
# I got loyalty,
got royalty inside my DNA #
938
00:51:54,066 --> 00:51:58,166
-Watson has been DNA's front man
for 50 years.
939
00:51:58,200 --> 00:52:00,266
That's because of
the "Double Helix" book.
940
00:52:00,300 --> 00:52:02,733
That's because of his work
at Cold Spring Harbor.
941
00:52:02,766 --> 00:52:05,866
[ Applause ]
942
00:52:05,900 --> 00:52:07,166
-James Watson.
943
00:52:07,200 --> 00:52:09,000
[ Cheers and applause ]
944
00:52:09,033 --> 00:52:11,533
-He made DNA "DNA."
945
00:52:15,266 --> 00:52:16,866
-Dino DNA.
946
00:52:16,900 --> 00:52:23,033
##
947
00:52:23,066 --> 00:52:25,100
-Even if you don't know anything
about genetics,
948
00:52:25,133 --> 00:52:26,966
you can say,
"Oh, it's in his DNA."
949
00:52:27,000 --> 00:52:29,200
-Sometimes I feel like
I have comedy in my genes.
950
00:52:29,233 --> 00:52:31,866
-If you want to find out
who you are,
951
00:52:31,900 --> 00:52:33,733
you can get
your DNA sequenced.
952
00:52:33,766 --> 00:52:35,400
-Jewish?!
953
00:52:37,933 --> 00:52:40,900
-So now, all of a sudden,
people have a molecule
954
00:52:40,933 --> 00:52:46,400
that they can put all of
their beliefs about heredity on.
955
00:52:49,666 --> 00:52:53,233
-I wanted to marry somebody
smart so my kids would be smart.
956
00:52:55,566 --> 00:52:58,566
I got a phone call from
my gynecologist, and he said,
957
00:52:58,600 --> 00:53:01,300
"Well, the future president
of the United States
958
00:53:01,333 --> 00:53:02,800
is on his way."
959
00:53:04,666 --> 00:53:10,333
In the winter of '70,
Rufus was born.
960
00:53:10,366 --> 00:53:15,266
-Everyone was in agreement
that Rufus was pretty bright,
961
00:53:15,300 --> 00:53:21,166
and I was very pleased,
because, you know, for a while,
962
00:53:21,200 --> 00:53:23,700
he would go
birdwatching with me,
963
00:53:23,733 --> 00:53:27,700
and we had some relationship.
964
00:53:31,366 --> 00:53:33,800
-Jim used to use the expression
965
00:53:33,833 --> 00:53:36,700
"A bad roll
of the genetic dice,"
966
00:53:36,733 --> 00:53:38,366
and, in fact...
967
00:53:40,900 --> 00:53:46,166
...genetically, Rufus did --
he was dealt a bad hand.
968
00:53:46,200 --> 00:53:49,666
-My son was damaged at birth.
969
00:53:49,700 --> 00:53:52,233
He was having difficulty
interacting with people
970
00:53:52,266 --> 00:53:54,300
when he was 3.
971
00:53:58,266 --> 00:53:59,800
When he was 10 years old,
972
00:53:59,833 --> 00:54:04,700
he began to have some sort
of social problems.
973
00:54:04,733 --> 00:54:10,000
The school suggested we take him
to a local child psychologist,
974
00:54:10,033 --> 00:54:17,133
and we had and, uh, just hoped
it would all disappear.
975
00:54:18,466 --> 00:54:21,066
-In 10th grade,
he had a full-blown
976
00:54:21,100 --> 00:54:26,366
psychotic event at Exeter,
and they sent him home.
977
00:54:28,933 --> 00:54:32,500
-He came home, and we put him
in the local high school,
978
00:54:32,533 --> 00:54:35,266
and three days later,
979
00:54:35,300 --> 00:54:41,500
he took himself into
the World Trade Center,
980
00:54:41,533 --> 00:54:45,333
where he went to the top with
the hope of ending his life.
981
00:54:47,066 --> 00:54:52,433
-We realized that Rufus
was very, very, very ill.
982
00:54:52,466 --> 00:54:56,700
-They said he had
sort of abnormalities
983
00:54:56,733 --> 00:55:00,633
which you frequently find
in schizophrenia.
984
00:55:00,666 --> 00:55:08,566
-I had never seen Jim weep
before or since in his life,
985
00:55:08,600 --> 00:55:10,900
and, you know,
this kind of emotion
986
00:55:10,933 --> 00:55:15,500
is not something that I'm used
to seeing from Jim, you know?
987
00:55:17,166 --> 00:55:22,900
He wanted Rufus cured, and I
just wanted Rufus to feel loved.
988
00:55:22,933 --> 00:55:25,500
You know, that's the difference.
989
00:55:25,533 --> 00:55:30,966
Moms tend to be -- They just
want to love their children,
990
00:55:31,000 --> 00:55:34,400
and men try to fix things.
991
00:55:36,033 --> 00:55:39,100
-I don't want to, in any sense,
be ashamed of him,
992
00:55:39,133 --> 00:55:40,600
which I am not.
993
00:55:40,633 --> 00:55:44,100
You know, he's really
a very lovable child, you know,
994
00:55:44,133 --> 00:55:47,900
and he's a nice person,
as well as being very bright.
995
00:55:52,233 --> 00:55:55,800
-Now, in this --
in this series, I mean,
996
00:55:55,833 --> 00:55:59,033
obviously, I'll be labeled
as a schizo, right?
997
00:55:59,066 --> 00:56:02,233
I mean, that would be truth
in advertising right?
998
00:56:02,266 --> 00:56:04,666
My dad will tell people,
"Oh, my son Rufus --
999
00:56:04,700 --> 00:56:07,200
he's bright,
but he's mentally ill,"
1000
00:56:07,233 --> 00:56:08,966
whereas I think of it
as the opposite.
1001
00:56:09,000 --> 00:56:12,900
I think I'm dim
but not mentally ill.
1002
00:56:12,933 --> 00:56:15,533
And so --
1003
00:56:15,566 --> 00:56:17,033
-No, it's unfair.
You're the kind of person
1004
00:56:17,066 --> 00:56:19,533
that -- that, uh --
1005
00:56:19,566 --> 00:56:23,000
that Pop has, like, fought for
his, like, whole career.
1006
00:56:23,033 --> 00:56:26,866
-Much human disease
has a genetic origin.
1007
00:56:26,900 --> 00:56:30,833
It's likely that mental illness
is not caused by one gene,
1008
00:56:30,866 --> 00:56:34,900
but there may be hundreds
if not thousands of them,
1009
00:56:34,933 --> 00:56:39,933
and so I would like to know,
where did his DNA go wrong?
1010
00:56:39,966 --> 00:56:42,033
-Good evening.
History will mark this day
1011
00:56:42,066 --> 00:56:44,900
as a milestone
in medicine and science.
1012
00:56:44,933 --> 00:56:47,766
Researchers have decoded
the human genome.
1013
00:56:47,800 --> 00:56:51,166
That's the sequence
of billions of DNA fragments
1014
00:56:51,200 --> 00:56:53,300
that are the recipe
for humankind.
1015
00:56:53,333 --> 00:56:57,366
-The seeds of the Human Genome
Project were essentially sewn
1016
00:56:57,400 --> 00:57:01,933
on February 28, 1953,
when Watson and Crick
1017
00:57:01,966 --> 00:57:03,900
walked into the pub
and Crick said,
1018
00:57:03,933 --> 00:57:06,066
"We've discovered
the secret of life!"
1019
00:57:06,100 --> 00:57:09,366
-We have about 22,000 genes.
1020
00:57:09,400 --> 00:57:11,933
Working out what
each of these does,
1021
00:57:11,966 --> 00:57:14,200
we'll find out what we are.
1022
00:57:14,233 --> 00:57:17,466
-In 1986, Jim Watson
had organized
1023
00:57:17,500 --> 00:57:19,600
the famous
Cold Spring Harbor Symposium
1024
00:57:19,633 --> 00:57:22,666
here at Cold Spring Harbor
on the human genome.
1025
00:57:22,700 --> 00:57:28,633
-It was really mental illness
that was the reason why I was
1026
00:57:28,666 --> 00:57:30,133
so keen to get it started.
1027
00:57:30,166 --> 00:57:32,000
-Jim didn't actually get to go
to that session
1028
00:57:32,033 --> 00:57:36,866
because Rufus had run away
the night before,
1029
00:57:36,900 --> 00:57:40,733
and Jim and Liz
were out hunting for Rufus.
1030
00:57:42,233 --> 00:57:44,833
-He brought the world's
most influential
1031
00:57:44,866 --> 00:57:46,966
human geneticists together,
1032
00:57:47,000 --> 00:57:50,100
and he decided to have
an afternoon of discussion
1033
00:57:50,133 --> 00:57:52,800
about whether we really should
sequence the human genome,
1034
00:57:52,833 --> 00:57:54,400
because there was
a lot of opposition
1035
00:57:54,433 --> 00:57:56,500
from very prominent scientists.
1036
00:57:56,533 --> 00:58:00,266
-The scale was outrageously
beyond anything
1037
00:58:00,300 --> 00:58:03,100
that seemed achievable,
so it was only people
1038
00:58:03,133 --> 00:58:06,200
who were willing
to think way outside of reality
1039
00:58:06,233 --> 00:58:09,800
that could develop enough
momentum to make it happen.
1040
00:58:09,833 --> 00:58:12,433
-A small group of us
came together and asked,
1041
00:58:12,466 --> 00:58:14,366
"Okay, if this was
going to happen,
1042
00:58:14,400 --> 00:58:16,966
who should be the person
who leads it?"
1043
00:58:17,000 --> 00:58:20,033
And we all agreed Jim Watson.
1044
00:58:20,066 --> 00:58:21,866
It's obvious.
It's perfect.
1045
00:58:21,900 --> 00:58:23,900
It's so poetic.
1046
00:58:23,933 --> 00:58:25,433
-Jim saw the end game.
1047
00:58:25,466 --> 00:58:29,233
He saw that he could go from
discovering the double helix
1048
00:58:29,266 --> 00:58:34,166
to having, in his lifetime,
a sequence of the human genome.
1049
00:58:34,200 --> 00:58:37,233
He had that confidence again
that we could do it
1050
00:58:37,266 --> 00:58:39,233
even though
we didn't know how to do it.
1051
00:58:39,266 --> 00:58:40,566
-And then there got to be
1052
00:58:40,600 --> 00:58:43,733
this tense disagreement
about patenting.
1053
00:58:43,766 --> 00:58:45,933
-Tonight's "Eye on America"
takes you to the frontiers
1054
00:58:45,966 --> 00:58:50,466
of science news --
locating the 100,000 genes.
1055
00:58:50,500 --> 00:58:54,833
Can those who discover
it all patent and own it?
1056
00:58:54,866 --> 00:58:58,000
-His boss was Bernadine Healy,
who supports the patent.
1057
00:58:58,033 --> 00:59:00,766
-She's Clint Eastwood in suits
and high heels --
1058
00:59:00,800 --> 00:59:03,466
dressed for tea,
ready for combat.
1059
00:59:03,500 --> 00:59:08,366
-Jim Watson was emotionally
violently opposed to that.
1060
00:59:10,866 --> 00:59:13,266
-She was a highly
intelligent woman
1061
00:59:13,300 --> 00:59:20,033
who I just thought doesn't know
as much as I do,
1062
00:59:20,066 --> 00:59:21,933
and she acts as if she does.
1063
00:59:21,966 --> 00:59:24,400
-He said, "No.
DNA is very special.
1064
00:59:24,433 --> 00:59:26,366
It's the storage
and transmission medium
1065
00:59:26,400 --> 00:59:30,400
of biological information,
so you can't patent it."
1066
00:59:30,433 --> 00:59:32,800
But you know what?
She's his boss,
1067
00:59:32,833 --> 00:59:36,433
and they're on opposite sides
of this patenting thing,
1068
00:59:36,466 --> 00:59:39,266
but they're on opposite sides
of a lot of things.
1069
00:59:39,300 --> 00:59:44,200
The patent story became
a very public controversy,
1070
00:59:44,233 --> 00:59:46,166
and in a way,
one of them had to lose.
1071
00:59:46,200 --> 00:59:48,566
-Do you swear to tell the truth,
the whole truth,
1072
00:59:48,600 --> 00:59:51,233
and nothing but the truth,
so help you, God?
1073
00:59:51,266 --> 00:59:54,766
-Some of us have a governor
on what we decide
1074
00:59:54,800 --> 00:59:57,533
we're going to articulate
that we might be thinking
1075
00:59:57,566 --> 01:00:00,866
but maybe wouldn't think
it's time to say it.
1076
01:00:00,900 --> 01:00:05,200
Jim's governor was perhaps
a little harder to perceive.
1077
01:00:05,233 --> 01:00:07,266
And there were times
when he would,
1078
01:00:07,300 --> 01:00:11,600
in a very blunt way and
a dismissive way, offend people.
1079
01:00:11,633 --> 01:00:14,600
And he, I gather,
called her a lunatic,
1080
01:00:14,633 --> 01:00:18,900
not once but more than once,
in front of open microphones.
1081
01:00:18,933 --> 01:00:22,866
-Not a good way to make friends
and influence people.
1082
01:00:26,200 --> 01:00:28,433
-Jim has a penchant
for opening his mouth
1083
01:00:28,466 --> 01:00:30,066
and sticking his foot in it.
1084
01:00:30,100 --> 01:00:33,600
-What I call
"foot in mouth disease."
1085
01:00:35,066 --> 01:00:37,866
He got himself in
a lot of trouble a few times.
1086
01:00:39,766 --> 01:00:43,933
-I'm just not afraid
to say what I think.
1087
01:00:43,966 --> 01:00:48,166
-He and Dr. Healy had a history,
so they didn't come into this
1088
01:00:48,200 --> 01:00:51,466
with a warm
and fuzzy relationship.
1089
01:00:51,500 --> 01:00:54,600
She basically had it and said,
"We're done with you,
1090
01:00:54,633 --> 01:00:57,933
and if you don't resign,
we will figure out a way
1091
01:00:57,966 --> 01:01:01,500
to get you out of here
that won't be pretty."
1092
01:01:01,533 --> 01:01:06,866
-In March 1992,
he sends in his resignation.
1093
01:01:06,900 --> 01:01:08,833
It was a dark day.
1094
01:01:08,866 --> 01:01:12,333
This project was barely out
of the gates.
1095
01:01:12,366 --> 01:01:14,766
This is like a baby
still in the crib.
1096
01:01:14,800 --> 01:01:17,433
And Daddy just left.
1097
01:01:17,466 --> 01:01:20,333
Jim certainly had offended
a fair number of people,
1098
01:01:20,366 --> 01:01:24,366
and it was necessary for me
to do some repairs there.
1099
01:01:24,400 --> 01:01:26,533
But I benefited greatly
by the fact
1100
01:01:26,566 --> 01:01:29,533
that he was the initiator
1101
01:01:29,566 --> 01:01:33,033
of a lot of what I then
got to take on.
1102
01:01:33,066 --> 01:01:34,900
[ Applause ]
1103
01:01:34,933 --> 01:01:39,466
We declared victory of the
completed Human Genome Project
1104
01:01:39,500 --> 01:01:43,000
goals in April of 2003.
1105
01:01:43,033 --> 01:01:52,666
##
1106
01:01:52,700 --> 01:01:55,100
-I don't think the genome
program would have come up
1107
01:01:55,133 --> 01:01:58,633
with any answer
for my condition.
1108
01:02:00,800 --> 01:02:03,733
I mean, my dad was successful,
so I always assumed
1109
01:02:03,766 --> 01:02:06,433
that I would be successful
at what I tried to do.
1110
01:02:07,800 --> 01:02:09,900
-Yeah, me too.
You make that assumption.
1111
01:02:09,933 --> 01:02:12,266
You kind of grow up
and you think, "Wow," you know?
1112
01:02:12,300 --> 01:02:14,233
"This Watson --
this is family thing, right?
1113
01:02:14,266 --> 01:02:16,033
He's extraordinary,
1114
01:02:16,066 --> 01:02:20,966
and, you know,
it's my genetic destiny."
1115
01:02:21,000 --> 01:02:24,166
And then, at a certain point,
you know, I started to --
1116
01:02:24,200 --> 01:02:25,766
"Oh, gee,
1117
01:02:25,800 --> 01:02:27,733
I wonder when I'm gonna have
my big ideas or something."
1118
01:02:27,766 --> 01:02:31,266
And then, you know,
that passed pretty quickly.
1119
01:02:31,300 --> 01:02:34,966
-I thought that I'd be smart,
but, you know,
1120
01:02:35,000 --> 01:02:41,166
it wasn't until I became aware
of how dim I was that I thought,
1121
01:02:41,200 --> 01:02:46,533
"Well, this is strange
because my dad's not dim."
1122
01:02:46,566 --> 01:02:49,100
Then I thought, "Well,
I'm a burden on my parents
1123
01:02:49,133 --> 01:02:50,400
because he's successful,
1124
01:02:50,433 --> 01:02:54,033
and doesn't he deserve
a successful child
1125
01:02:54,066 --> 01:02:57,666
because he's worked hard,
and, if you believe in karma,
1126
01:02:57,700 --> 01:03:01,533
then he should have earned
himself a successful son."
1127
01:03:01,566 --> 01:03:06,533
##
1128
01:03:09,933 --> 01:03:12,966
But, Pop, do you still
consider yourself a scientist?
1129
01:03:13,000 --> 01:03:14,566
-Yes.
1130
01:03:15,800 --> 01:03:17,900
I'm probably still the best
scientist here
1131
01:03:17,933 --> 01:03:19,566
in Cold Spring Harbor.
1132
01:03:21,966 --> 01:03:24,900
##
1133
01:03:24,933 --> 01:03:29,666
-He came here when he was 20,
and it's been his whole life.
1134
01:03:31,366 --> 01:03:33,233
-In an important way,
Cold Spring Harbor
1135
01:03:33,266 --> 01:03:39,100
is Jim Watson, and he's very,
very devoted to the place.
1136
01:03:39,133 --> 01:03:44,166
##
1137
01:03:44,200 --> 01:03:47,000
I would say that it is
one of the things
1138
01:03:47,033 --> 01:03:51,966
that he probably feels he's
gonna be most remembered for.
1139
01:03:52,000 --> 01:03:57,366
##
1140
01:03:57,400 --> 01:03:58,966
-Scientists on both sides
of the Atlantic
1141
01:03:59,000 --> 01:04:01,033
are now up in arms over comments
1142
01:04:01,066 --> 01:04:05,133
quoted from the biologist
and Nobel Laureate James Watson.
1143
01:04:05,166 --> 01:04:08,133
-Watson sparked a furor
when the UK's
The Sunday Times
1144
01:04:08,166 --> 01:04:09,566
quoted him saying,
1145
01:04:09,600 --> 01:04:12,566
"I'm inherently gloomy
about the prospect of Africa,"
1146
01:04:12,600 --> 01:04:15,633
adding, "All our social policies
are based on the fact
1147
01:04:15,666 --> 01:04:18,300
that their intelligence
is the same as ours,
1148
01:04:18,333 --> 01:04:20,700
whereas all the testing says
not really."
1149
01:04:20,733 --> 01:04:23,300
-In 2007, he made...
1150
01:04:26,200 --> 01:04:29,766
...some very unfortunate
comments about
1151
01:04:29,800 --> 01:04:31,133
race and intelligence.
1152
01:04:31,166 --> 01:04:36,533
-It was like a bomb
going off on campus, so, uh...
1153
01:04:36,566 --> 01:04:39,633
it sent everything
kind of spinning.
1154
01:04:39,666 --> 01:04:44,233
-I thought, "Whoa.
This is not good.
1155
01:04:44,266 --> 01:04:46,033
I mean, what's happened,
you know?
1156
01:04:46,066 --> 01:04:48,700
Where's the Jim I knew?"
1157
01:04:48,733 --> 01:04:50,066
-And that wasn't all.
1158
01:04:50,100 --> 01:04:53,666
Watson was quoted as saying
he hopes everyone is equal
1159
01:04:53,700 --> 01:04:55,400
but "People who have to deal
1160
01:04:55,433 --> 01:04:58,266
with black employees
find this not true."
1161
01:05:00,166 --> 01:05:04,366
-He said anyone who has had
black employees knows
1162
01:05:04,400 --> 01:05:06,466
that this is not the case.
1163
01:05:07,833 --> 01:05:11,666
Right.
Just put the little...
1164
01:05:11,700 --> 01:05:14,200
dig right in there.
Yeah.
1165
01:05:14,233 --> 01:05:16,700
-Tonight the Nobel Laureate's
job at a prestigious laboratory
1166
01:05:16,733 --> 01:05:19,466
is on the line and his
reputation is badly bruised.
1167
01:05:19,500 --> 01:05:21,166
Are there any studies
or any tests
1168
01:05:21,200 --> 01:05:22,200
that support his statement?
1169
01:05:22,233 --> 01:05:23,633
I mean, what is
he talking about?
1170
01:05:23,666 --> 01:05:26,600
-Well, he is talking about
a literature that developed
1171
01:05:26,633 --> 01:05:30,666
over the 20th century
in basic IQ testing
1172
01:05:30,700 --> 01:05:34,000
that does show a result
of persons of European descent
1173
01:05:34,033 --> 01:05:36,933
and persons of East Asian
descent in the United States
1174
01:05:36,966 --> 01:05:41,133
and also across Europe and Asia
scoring higher on IQ tests
1175
01:05:41,166 --> 01:05:43,200
than persons of African descent.
1176
01:05:43,233 --> 01:05:45,300
Now, one has to be
very careful, however,
1177
01:05:45,333 --> 01:05:48,433
about imputing a meaning to
the differences in the results,
1178
01:05:48,466 --> 01:05:50,166
particularly a genetic meaning.
1179
01:05:50,200 --> 01:05:53,233
The most obvious causal factor
1180
01:05:53,266 --> 01:05:55,066
that would be accounting
for the differences
1181
01:05:55,100 --> 01:05:57,900
in IQ test scores would be
the physical environment
1182
01:05:57,933 --> 01:05:59,266
that the two groups live in.
1183
01:05:59,300 --> 01:06:02,100
In the United States,
European-Americans
1184
01:06:02,133 --> 01:06:04,566
and African-Americans
have never lived in the same
1185
01:06:04,600 --> 01:06:09,566
social, environmental, economic,
and physical environments,
1186
01:06:09,600 --> 01:06:11,833
and, hence,
any outcome from those tests
1187
01:06:11,866 --> 01:06:14,033
cannot be ascribed
to genetic sources.
1188
01:06:14,066 --> 01:06:17,500
-The brain, it's a device.
1189
01:06:17,533 --> 01:06:19,366
Yes, the genes make the device,
1190
01:06:19,400 --> 01:06:23,300
but what it's capable of doing
depends on having good nutrition
1191
01:06:23,333 --> 01:06:25,933
and 8 trillion things
we don't begin to understand.
1192
01:06:25,966 --> 01:06:30,133
-Furthermore, it's not agreed
upon by psychologists
1193
01:06:30,166 --> 01:06:35,533
that IQ tests are actually
really measuring intelligence.
1194
01:06:35,566 --> 01:06:36,800
-Were you surprised to hear
1195
01:06:36,833 --> 01:06:38,066
Dr. Watson making
these comments?
1196
01:06:38,100 --> 01:06:39,666
I mean, there is a history here
of this man
1197
01:06:39,700 --> 01:06:42,566
making some very
controversial statements.
1198
01:06:42,600 --> 01:06:44,466
-Well, in Watson's case here,
1199
01:06:44,500 --> 01:06:45,833
he's really talking
about things,
1200
01:06:45,866 --> 01:06:47,866
personal beliefs and biases
that he has
1201
01:06:47,900 --> 01:06:49,466
that he'd
like
to be true
1202
01:06:49,500 --> 01:06:51,433
and that there's really
no scientific evidence for,
1203
01:06:51,466 --> 01:06:53,400
and I find that irresponsible.
1204
01:06:53,433 --> 01:06:56,366
I'm the first person
of African-American descent
1205
01:06:56,400 --> 01:06:59,566
to have ever earned a PhD
in evolutionary biology.
1206
01:06:59,600 --> 01:07:02,666
And when I was interviewed
by Anderson Cooper,
1207
01:07:02,700 --> 01:07:06,100
I tried to maintain
the scientific high ground
1208
01:07:06,133 --> 01:07:09,933
and not in the interview, um,
1209
01:07:09,966 --> 01:07:15,766
give to the viewing audience
the pain that I feel every time
1210
01:07:15,800 --> 01:07:22,100
I read these words about how,
because of my genetic heritage,
1211
01:07:22,133 --> 01:07:26,100
I can't be or am not as good
a scientist as Watson was.
1212
01:07:27,500 --> 01:07:31,633
-For me, personally, he stands
for -- in my world,
1213
01:07:31,666 --> 01:07:34,866
stands for critical,
radical thought,
1214
01:07:34,900 --> 01:07:40,333
and, you know,
how you can go back to a...
1215
01:07:40,366 --> 01:07:46,400
old, rooted notion, um...
1216
01:07:46,433 --> 01:07:50,033
that has nothing to do
with critical thinking today --
1217
01:07:50,066 --> 01:07:52,100
I don't know.
I really don't know.
1218
01:07:52,133 --> 01:07:53,800
-It's not science-based,
1219
01:07:53,833 --> 01:07:56,866
and that's what makes
you concerned that,
1220
01:07:56,900 --> 01:07:59,200
"What happened
to cause him to say it?"
1221
01:08:01,566 --> 01:08:02,900
-We had been in the habit
1222
01:08:02,933 --> 01:08:06,800
of taking gap-year kids
from England.
1223
01:08:06,833 --> 01:08:10,633
-And Jim and Liz
had a young woman
1224
01:08:10,666 --> 01:08:13,233
who was staying with them
for a year
1225
01:08:13,266 --> 01:08:15,733
who worked at the laboratory,
1226
01:08:15,766 --> 01:08:18,200
she went back
and became a journalist.
1227
01:08:18,233 --> 01:08:19,866
-Somehow, she got herself
the job
1228
01:08:19,900 --> 01:08:21,466
of writing a profile of him.
1229
01:08:21,500 --> 01:08:24,666
-And he gave an interview.
1230
01:08:24,700 --> 01:08:29,133
-And, unfortunately, she had her
tape recorder running,
1231
01:08:29,166 --> 01:08:32,266
which, um, I doubt
1232
01:08:32,300 --> 01:08:35,066
my husband was aware of the fact
that she had it running.
1233
01:08:35,100 --> 01:08:39,700
He said, "Why don't you come
with me to the tennis game,
1234
01:08:39,733 --> 01:08:41,366
and we can talk in the car?"
1235
01:08:43,466 --> 01:08:45,933
-Yeah, I was trying
to keep the girl amused
1236
01:08:45,966 --> 01:08:49,800
as I drove her back
from watching me play tennis.
1237
01:08:49,833 --> 01:08:51,833
That's it.
[ Laughs ]
1238
01:08:51,866 --> 01:08:55,966
So, what really concerned me
was how my tennis was.
1239
01:08:58,066 --> 01:09:02,366
From the moment I read it,
I knew I was in deep [bleep]
1240
01:09:02,400 --> 01:09:04,300
-It was picked up
in the British press,
1241
01:09:04,333 --> 01:09:07,666
and then it just blew up
in a few days.
1242
01:09:07,700 --> 01:09:10,166
-Well, you get into trouble.
You can't control yourself.
1243
01:09:10,200 --> 01:09:11,833
I mean, but sometimes
we don't know.
1244
01:09:11,866 --> 01:09:13,500
I mean, just take
the race stuff that --
1245
01:09:13,533 --> 01:09:14,833
Africa and Europe.
-Yeah.
1246
01:09:14,866 --> 01:09:16,466
-The question still is
how could someone as smart
1247
01:09:16,500 --> 01:09:19,033
as you are say what you did?
1248
01:09:19,066 --> 01:09:22,533
-Oh, I was saying
something to a girl.
1249
01:09:22,566 --> 01:09:23,833
I never thought of her
as a reporter.
1250
01:09:23,866 --> 01:09:25,366
She lived in our house
for a year.
1251
01:09:25,400 --> 01:09:27,400
-Well, that doesn't
make any difference.
1252
01:09:27,433 --> 01:09:29,733
-I was treating her
like a daughter, and --
1253
01:09:29,766 --> 01:09:31,166
-That doesn't make
any difference, either.
1254
01:09:31,200 --> 01:09:34,033
Did you think the thought?
1255
01:09:34,066 --> 01:09:36,766
-Sure, I thought the thought,
whether it was right or wrong.
1256
01:09:36,800 --> 01:09:39,400
I didn't think it appropriate
ever to say it in public.
1257
01:09:39,433 --> 01:09:40,766
-Right.
1258
01:09:42,300 --> 01:09:46,000
-I never expected this woman
who lived with us for a year
1259
01:09:46,033 --> 01:09:47,566
would write an article
1260
01:09:47,600 --> 01:09:52,700
which would make me
despised by so many people.
1261
01:09:55,533 --> 01:09:57,133
I regret it.
1262
01:09:57,166 --> 01:10:02,333
I can't erase it by now saying
I never meant what I said.
1263
01:10:07,100 --> 01:10:09,333
-I just -- We were devastated.
1264
01:10:09,366 --> 01:10:12,100
I really can't remember
'cause it was really bad.
1265
01:10:12,133 --> 01:10:13,400
That's all I can think of.
1266
01:10:13,433 --> 01:10:16,000
-Do you recognize it was off?
-Oh, God, yes.
1267
01:10:16,033 --> 01:10:17,633
Instantly, I saw...
1268
01:10:20,300 --> 01:10:22,300
You know, this is the worst
trouble ever in my life...
1269
01:10:22,333 --> 01:10:24,633
-Exactly. It was.
-...because it hurt people,
1270
01:10:24,666 --> 01:10:26,733
and I didn't intend
to hurt people,
1271
01:10:26,766 --> 01:10:30,666
and it implied
that some people I work with
1272
01:10:30,700 --> 01:10:31,966
I have poor impressions of.
1273
01:10:32,000 --> 01:10:33,133
I don't.
1274
01:10:33,166 --> 01:10:35,833
-I had calls from Washington
1275
01:10:35,866 --> 01:10:38,066
that were saying,
"Should Cold Spring Harbor
1276
01:10:38,100 --> 01:10:41,500
even be supported
by public research grants
1277
01:10:41,533 --> 01:10:44,500
with somebody who has
an attitude like that?"
1278
01:10:44,533 --> 01:10:47,833
My main concern at that time
was making sure
1279
01:10:47,866 --> 01:10:50,966
that Cold Spring Harbor,
the institution, in 2007
1280
01:10:51,000 --> 01:10:54,500
was not gonna be linked to
statements which fundamentally,
1281
01:10:54,533 --> 01:10:58,566
I think, haven't been proven and
are very, very controversial.
1282
01:10:58,600 --> 01:11:01,866
Part of the reason for that
is the history of eugenics here,
1283
01:11:01,900 --> 01:11:06,466
going way back into
the 1920s, 100 years ago.
1284
01:11:08,000 --> 01:11:11,033
I didn't want Cold Spring Harbor
to get recast
1285
01:11:11,066 --> 01:11:15,533
in the era
of the eugenics movement again.
1286
01:11:17,166 --> 01:11:20,533
-Early on in the history
of Cold Spring,
1287
01:11:20,566 --> 01:11:24,166
a scientist named
Charles Davenport
1288
01:11:24,200 --> 01:11:28,766
took over the leadership of
the biological research there.
1289
01:11:28,800 --> 01:11:32,166
He believed in what was known
as eugenics --
1290
01:11:32,200 --> 01:11:37,033
that if you prevented certain
people from having children
1291
01:11:37,066 --> 01:11:39,933
and promoted other people
to have children
1292
01:11:39,966 --> 01:11:45,333
based on their genes, you could
improve the human race.
1293
01:11:45,366 --> 01:11:47,400
Thousands and thousands
and thousands of people
1294
01:11:47,433 --> 01:11:52,966
were sterilized
because they were deemed unfit.
1295
01:11:53,000 --> 01:11:55,133
-By the 1930s,
1296
01:11:55,166 --> 01:11:58,266
the only people who
were promoting it were Nazis.
1297
01:11:58,300 --> 01:11:59,600
They were awful!
1298
01:11:59,633 --> 01:12:03,433
-The Nazis in Germany were
embracing eugenics
1299
01:12:03,466 --> 01:12:04,966
and promoting it.
1300
01:12:05,000 --> 01:12:08,666
They were celebrating the work
of these American eugenicists.
1301
01:12:08,700 --> 01:12:10,133
But back in the United States,
1302
01:12:10,166 --> 01:12:13,600
people like Charles Davenport
were on the outs.
1303
01:12:13,633 --> 01:12:15,600
Other scientists were realizing
that it was
1304
01:12:15,633 --> 01:12:18,200
just a way of justifying racism.
1305
01:12:18,233 --> 01:12:23,200
All these old attitudes
were being propped up
1306
01:12:23,233 --> 01:12:27,000
by a poor reading of genetics.
1307
01:12:27,033 --> 01:12:32,500
By the time that Watson arrives
in Cold Spring in 1948,
1308
01:12:32,533 --> 01:12:37,866
this sordid history
with eugenics is in the past.
1309
01:12:37,900 --> 01:12:43,100
-I was not in the slightest
interested in eugenics,
1310
01:12:43,133 --> 01:12:46,366
nor was anyone there.
1311
01:12:46,400 --> 01:12:49,366
-The laboratory has been
incredibly open,
1312
01:12:49,400 --> 01:12:52,600
putting all of this up
on the web that was,
1313
01:12:52,633 --> 01:12:54,366
you know, under Jim's watch,
1314
01:12:54,400 --> 01:12:57,766
and, in fact, he and I
have had this discussion --
1315
01:12:57,800 --> 01:13:00,533
that, given the history
of the laboratory and eugenics,
1316
01:13:00,566 --> 01:13:04,566
we can't revive this.
1317
01:13:07,533 --> 01:13:11,333
-They must have had
board members come out
1318
01:13:11,366 --> 01:13:12,866
from New York to,
1319
01:13:12,900 --> 01:13:17,933
you know, decide whether
he should be fired or not.
1320
01:13:17,966 --> 01:13:19,966
-There was some sentiment
to ask him to,
1321
01:13:20,000 --> 01:13:22,466
you know, step down from
the laboratory completely,
1322
01:13:22,500 --> 01:13:24,366
and I completely opposed that.
1323
01:13:24,400 --> 01:13:27,866
That was not even remotely
on the radar screen for me.
1324
01:13:27,900 --> 01:13:32,300
-And the next day, Jim was fired
without a lawyer or anything.
1325
01:13:32,333 --> 01:13:35,233
It was -- It was --
It was like a kangaroo court.
1326
01:13:35,266 --> 01:13:36,966
-We wanted to make it clear
that Jim Watson
1327
01:13:37,000 --> 01:13:40,400
had no administrative role
at the laboratory.
1328
01:13:40,433 --> 01:13:42,700
That did not mean
that we fired him.
1329
01:13:42,733 --> 01:13:45,500
That meant that
we made it explicit
1330
01:13:45,533 --> 01:13:48,866
that he had
no administrative role.
1331
01:13:48,900 --> 01:13:53,000
I don't think what he said
was defensible,
1332
01:13:53,033 --> 01:13:56,533
mainly the comment about
African-American employees.
1333
01:13:56,566 --> 01:14:00,966
I wish he had,
for lots of reasons
1334
01:14:01,000 --> 01:14:03,666
but mainly for his own reasons,
1335
01:14:03,700 --> 01:14:07,833
he would think a little bit more
about what he says
1336
01:14:07,866 --> 01:14:12,566
because he has done so many
amazing things in his life.
1337
01:14:12,600 --> 01:14:14,166
-That's fine.
1338
01:14:14,200 --> 01:14:17,900
-He called late yesterday to say
he's back from Colorado.
1339
01:14:17,933 --> 01:14:20,400
-You know, Jim's still here.
1340
01:14:20,433 --> 01:14:22,833
He has still retained an office
and an assistant,
1341
01:14:22,866 --> 01:14:27,733
and he plays a role as
a scientist at the laboratory.
1342
01:14:27,766 --> 01:14:34,266
I think he is an extraordinarily
valued person still...
1343
01:14:34,300 --> 01:14:37,233
despite some of the things
that he said.
1344
01:14:37,266 --> 01:14:42,866
##
1345
01:14:42,900 --> 01:14:50,100
-Given my desire never to stay
away from messy problems,
1346
01:14:50,133 --> 01:14:53,466
I was bound to [bleep]
myself sometime.
1347
01:14:53,500 --> 01:14:55,133
And that's what I did.
1348
01:14:57,700 --> 01:14:59,866
-Have your views
on the relationship
1349
01:14:59,900 --> 01:15:02,233
between race
and intelligence changed?
1350
01:15:02,266 --> 01:15:05,733
-No, not at all.
I would like for them to change,
1351
01:15:05,766 --> 01:15:10,100
since there be new knowledge
which, uh...
1352
01:15:10,133 --> 01:15:14,200
says that, uh, your...
1353
01:15:14,233 --> 01:15:19,266
nurture is much more important
than nature.
1354
01:15:19,300 --> 01:15:21,566
But I haven't seen
any knowledge,
1355
01:15:21,600 --> 01:15:24,833
and there's a difference,
on the average,
1356
01:15:24,866 --> 01:15:27,500
between blacks and whites
on IQ tests.
1357
01:15:27,533 --> 01:15:31,466
I would say the difference
is, uh...
1358
01:15:35,066 --> 01:15:37,700
It's genetic.
1359
01:15:37,733 --> 01:15:40,033
-He's...
1360
01:15:40,066 --> 01:15:42,166
wrong, you know?
1361
01:15:42,200 --> 01:15:43,533
He's just wrong.
1362
01:15:43,566 --> 01:15:46,833
-Race is less a biological
construct of humans
1363
01:15:46,866 --> 01:15:48,933
and more a social construct.
1364
01:15:48,966 --> 01:15:51,333
We know a great deal
about human genetic variation
1365
01:15:51,366 --> 01:15:52,966
and how it's apportioned
around the world.
1366
01:15:53,000 --> 01:15:55,033
There is absolutely no evidence
1367
01:15:55,066 --> 01:15:57,333
that there are genetic
differences
1368
01:15:57,366 --> 01:16:01,966
that favor intelligence in any
subpopulation of human beings --
1369
01:16:02,000 --> 01:16:03,600
none whatsoever.
1370
01:16:03,633 --> 01:16:06,866
-I'm a product
of the Roosevelt era.
1371
01:16:06,900 --> 01:16:12,133
And if you ask me
what people thought
1372
01:16:12,166 --> 01:16:14,233
about race in the Roosevelt era,
1373
01:16:14,266 --> 01:16:17,900
we thought
there were differences.
1374
01:16:17,933 --> 01:16:19,366
You know?
1375
01:16:19,400 --> 01:16:22,400
Thomas Jefferson thought
there were differences.
1376
01:16:23,533 --> 01:16:33,000
##
1377
01:16:33,033 --> 01:16:37,466
It should be no surprise
that someone who wanted to find
1378
01:16:37,500 --> 01:16:41,333
the double helix believed
that genes were important.
1379
01:16:44,566 --> 01:16:48,066
-Racism suspends
all rational judgment.
1380
01:16:48,100 --> 01:16:49,433
It really does.
1381
01:16:49,466 --> 01:16:50,966
And it's one of the most
insidious things
1382
01:16:51,000 --> 01:16:52,533
that racism does.
1383
01:16:52,566 --> 01:16:55,766
It takes people who are
otherwise brilliant people
1384
01:16:55,800 --> 01:16:57,100
and gets them down roads
1385
01:16:57,133 --> 01:17:01,800
that are intellectually
unsupportable.
1386
01:17:01,833 --> 01:17:06,033
-Jim's been called a racist,
but a racist is someone
1387
01:17:06,066 --> 01:17:11,333
who makes the life of someone
1388
01:17:11,366 --> 01:17:19,033
who he has a strong feeling
of dislike for miserable.
1389
01:17:19,066 --> 01:17:21,200
-The guy was clearly wrong,
you know?
1390
01:17:21,233 --> 01:17:22,733
It's just --
1391
01:17:22,766 --> 01:17:25,633
It's just fundamentally wrong
to judge people by their race.
1392
01:17:25,666 --> 01:17:28,800
My point is that that's --
that's the --
1393
01:17:28,833 --> 01:17:32,233
the antithesis of who he is --
1394
01:17:32,266 --> 01:17:35,300
is actually a person
who's extremely compassionate
1395
01:17:35,333 --> 01:17:37,766
and would look at people
suffering from a disease
1396
01:17:37,800 --> 01:17:42,400
and say, "It doesn't matter
what their religion is
1397
01:17:42,433 --> 01:17:44,633
or their ethnicity.
1398
01:17:44,666 --> 01:17:46,066
None of that really matters."
1399
01:17:46,100 --> 01:17:49,566
-What my dad doesn't understand
is that because people
1400
01:17:49,600 --> 01:17:54,000
worship him and treat him
like this living god,
1401
01:17:54,033 --> 01:17:56,000
that when you're in
a position like that,
1402
01:17:56,033 --> 01:17:58,466
you have to be extra careful
about what you say.
1403
01:17:58,500 --> 01:18:01,066
-He's been put on a pedestal
1404
01:18:01,100 --> 01:18:04,366
because of the significant
impact that his --
1405
01:18:04,400 --> 01:18:08,766
his science had
and continues to have,
1406
01:18:08,800 --> 01:18:11,300
but the responsibility
that comes with being
1407
01:18:11,333 --> 01:18:14,233
on that pedestal
is not being met.
1408
01:18:14,266 --> 01:18:17,266
-I would actually thank him
for his work
1409
01:18:17,300 --> 01:18:19,700
on the discovery
of the structure for DNA,
1410
01:18:19,733 --> 01:18:22,566
and that should not be
taken away from him,
1411
01:18:22,600 --> 01:18:25,866
despite the fact that
he holds views that I would --
1412
01:18:25,900 --> 01:18:29,133
social views
that I feel are abhorrent.
1413
01:18:29,166 --> 01:18:34,700
-To the extent, uh, that, uh...
1414
01:18:34,733 --> 01:18:38,700
I have hurt people,
of course I regret it,
1415
01:18:38,733 --> 01:18:42,633
and, you know,
I like black people,
1416
01:18:42,666 --> 01:18:44,733
so why would
I want to hurt them?
1417
01:18:44,766 --> 01:18:49,266
I don't know anyone who --
who takes any pleasure
1418
01:18:49,300 --> 01:18:52,366
on the differences
between black and white
1419
01:18:52,400 --> 01:18:54,766
which didn't exist.
1420
01:18:54,800 --> 01:18:59,466
What? It's awful, just like
it's awful for schizophrenics.
1421
01:18:59,500 --> 01:19:03,333
But if the difference exists,
then we have to ask ourselves,
1422
01:19:03,366 --> 01:19:07,466
"How can we try
and make it better?"
1423
01:19:07,500 --> 01:19:10,200
-I just don't --
I don't understand it.
1424
01:19:10,233 --> 01:19:12,800
It is very painful
because I do love this man.
1425
01:19:12,833 --> 01:19:14,766
I mean, you have to love
the teacher
1426
01:19:14,800 --> 01:19:17,633
who gave you
your life in science.
1427
01:19:17,666 --> 01:19:21,466
I do love that person, you know,
and you have to.
1428
01:19:21,500 --> 01:19:23,600
And I admire what he did for,
you know,
1429
01:19:23,633 --> 01:19:25,333
creating a world of science
1430
01:19:25,366 --> 01:19:27,500
and creating the careers
of all these people
1431
01:19:27,533 --> 01:19:31,333
who every one was privileged
to have known such a person.
1432
01:19:31,366 --> 01:19:34,566
I don't know.
It's tough.
1433
01:19:37,800 --> 01:19:41,533
-I guess what I think about is
after my dad's died,
1434
01:19:41,566 --> 01:19:42,966
how will people judge him?
1435
01:19:43,000 --> 01:19:44,866
And...
1436
01:19:44,900 --> 01:19:48,700
this is sort of an anecdote,
but I saw this video,
1437
01:19:48,733 --> 01:19:53,366
and it showed this albino
orangutan with blue eyes.
1438
01:19:53,400 --> 01:19:54,733
It wasn't albino.
1439
01:19:54,766 --> 01:19:57,100
Whatever it is --
had white fur and blue eyes.
1440
01:19:57,133 --> 01:19:58,966
And it looked just like my dad.
1441
01:19:59,000 --> 01:20:01,133
And I thought,
"Well, if this orangutan looks
1442
01:20:01,166 --> 01:20:03,600
just like my dad,
what does this prove?
1443
01:20:03,633 --> 01:20:06,300
Does this prove that this
orangutan is highly intelligent,
1444
01:20:06,333 --> 01:20:10,033
or does it prove
that my dad's simply a monkey?"
1445
01:20:10,066 --> 01:20:13,900
And when I saw this video of
this monkey looking like my dad,
1446
01:20:13,933 --> 01:20:15,966
I was like -- it was just weird,
1447
01:20:16,000 --> 01:20:18,966
because that's my position,
that we're --
1448
01:20:19,000 --> 01:20:22,433
you know, humans are all monkeys
and we wear clothes
1449
01:20:22,466 --> 01:20:27,833
and we live in houses,
but, you know, my dad's a monkey
1450
01:20:27,866 --> 01:20:29,466
that made the most of it,
you know?
1451
01:20:29,500 --> 01:20:32,400
I-I -- That's the way I see it.
1452
01:20:32,433 --> 01:20:35,266
And he's just hoping
he doesn't die a monkey death,
1453
01:20:35,300 --> 01:20:40,233
you know, falling on the
forest floor and being ignored.
1454
01:20:40,266 --> 01:20:41,766
I don't know.
1455
01:20:41,800 --> 01:20:50,900
##
1456
01:20:50,933 --> 01:20:55,400
-Rufus asked me how I wanted
myself portrayed.
1457
01:20:55,433 --> 01:20:57,833
You know, what was
a take-home lesson
1458
01:20:57,866 --> 01:21:00,033
after turning off the tube
1459
01:21:00,066 --> 01:21:02,833
and seeing me
for a couple hours?
1460
01:21:06,133 --> 01:21:10,666
I said, "I just always wanted
to be exceptional."
1461
01:21:10,700 --> 01:21:14,400
I think I have achieved that.
1462
01:21:14,433 --> 01:21:19,133
I want to be portrayed
as someone who was concerned
1463
01:21:19,166 --> 01:21:20,866
for the world about me
1464
01:21:20,900 --> 01:21:25,466
as important
as my concern for myself.
1465
01:21:29,366 --> 01:21:33,300
You know,
now I really miss Crick.
1466
01:21:33,333 --> 01:21:38,700
I don't have anyone I can talk
to now of Crick's intelligence.
1467
01:21:39,700 --> 01:21:42,000
Francis, do you think we were
lucky to have solved it,
1468
01:21:42,033 --> 01:21:44,166
or was it real brainwork?
1469
01:21:44,200 --> 01:21:46,466
-Well, I guess we were
certainly lucky.
1470
01:21:46,500 --> 01:21:48,633
We were lucky, I think,
for two reasons.
1471
01:21:48,666 --> 01:21:51,400
We were thinking about
the problem at the right time,
1472
01:21:51,433 --> 01:21:53,800
and then the two of us,
by collaborating,
1473
01:21:53,833 --> 01:21:55,666
when one of us
got on the wrong track,
1474
01:21:55,700 --> 01:21:57,866
the other one
could get us out of it.
1475
01:21:57,900 --> 01:22:01,200
We weren't at least afraid of
being very candid to each other,
1476
01:22:01,233 --> 01:22:04,333
to the point of being rude.
1477
01:22:04,366 --> 01:22:05,633
-You know, after I'm dead,
1478
01:22:05,666 --> 01:22:08,133
I'll be more famous
than I am now
1479
01:22:08,166 --> 01:22:11,900
because DNA gets more famous.
1480
01:22:11,933 --> 01:22:14,466
DNA is not overrated.
1481
01:22:14,500 --> 01:22:16,233
[ Laughs ] You know?
1482
01:22:16,266 --> 01:22:18,266
Some -- Some things come and go.
1483
01:22:18,300 --> 01:22:20,233
Oh, DNA won't come and go.
1484
01:22:20,266 --> 01:22:25,233
##
1485
01:22:25,633 --> 01:22:31,800
####
1486
01:22:31,833 --> 01:22:38,033
##
1487
01:22:38,066 --> 01:22:40,666
To order "Decoding Watson"
1488
01:22:38,066 --> 01:22:40,666
on
\h
DVD,
1489
01:22:40,700 --> 01:22:44,900
visit Shop PBS
1490
01:22:40,700 --> 01:22:44,900
or
\h
call 1-800-PLAY-PBS.
1491
01:22:44,933 --> 01:22:48,266
This program is also available
1492
01:22:44,933 --> 01:22:48,266
on
\h
Amazon Prime Video.
1493
01:22:48,300 --> 01:22:53,766
##
1494
01:22:53,800 --> 01:22:56,166
Davis: I'm colored, Jewish,
and Puerto Rican.
1495
01:22:56,200 --> 01:22:59,166
When I move into a neighborhood,
I wipe it out.
1496
01:22:59,200 --> 01:23:00,700
Man: Sammy Davis Jr.'s
whole life
1497
01:23:00,733 --> 01:23:02,133
was about confronting obstacles.
1498
01:23:02,166 --> 01:23:04,500
Davis: # Mr. Bojangles
1499
01:23:04,533 --> 01:23:06,133
# I gotta be
1500
01:23:06,166 --> 01:23:07,333
Man: But he had
a vision for himself
1501
01:23:07,366 --> 01:23:08,733
that was bigger
than white or black.
1502
01:23:08,766 --> 01:23:10,266
Davis: # Me!
1503
01:23:10,300 --> 01:23:14,166
Sammy Davis Jr., coming soon
1504
01:23:10,300 --> 01:23:14,166
to
\h
"American Masters."
1505
01:23:14,200 --> 01:23:21,666
##
120021
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