All language subtitles for The.Ozempic.Effe

Oh, oh, how does it go?
[singing] Oh...

-Oh!
-Oh!

♪ Ozempic! ♪

In case you’ve
been under a rock,

Ozempic is a new class of
weight loss drug

that is delivering
astonishing results.

These drugs have become
all the rage in Hollywood.

From Golden Globe jokes...

And welcome to the
82nd Golden Globes...

Ozempic’s biggest night.

To testimonials from
Oprah, Sharon Osborne,

and Amy Schumer,
the secret is out.

Sharon: I lost 45, yeah.
Yeah, it was 45 pounds.

Amy: A smaller portion?
Like, shut the [beep] up.

You’re on Ozempic.

What’s the biggest
game changer right now?

Everyone says the GLP-1s.

McDonald’s stock price
is down again.

Some analysts think
Ozempic is to blame.

It appears Ozempic and
pharmaceutical knockoffs

are in such high demand,
black market websites

have popped up overnight.

They’re basically churning out
prescriptions like crazy.

It is the most radical
transformation

that we’ve seen in the
pharmacology of weight loss.

Ever.

We want to pop the pill that
gives us all the effects of

exercise without
actually exercising.

Like, everyone
is shrinking.

People drink a whole
heck of a lot less

on these medications.

The Ozempic effect,
Ozempic face, Ozempic butt.

Ozempic can lead
to loose breasts.

Is this how
Ozempic works?

Do you lose weight because

you’re expelling everything
in your soul?

Who’s monitoring it
for side effects?

And who’s adjusting for
your other medications?

Nobody.

This medication is not just
an appetite suppressant.

It has a deep effect
practically in every organ

in the body.

Impulse control is up,
body inflammation down.

I think it will be probably
one of the most

popular drugs of all time.

SFX: [zipping]

[stretching & snapping]

♪

♪

I’m Dr. Jason Fung.

I wrote several books,
including The Obesity Code.

So a GLP-1 is a specific
hormone in our body

that tells us essentially
to stop eating.

The most well-known,
the Ozempic,

slows down the movement
of food in our stomach.

So therefore, if things are
not moving out of our stomach,

they’re just
sitting there, well,

you’re not gonna want to
eat because, you know,

all that food is
just sitting there.

There’s plenty of positives
weight loss can have,

for sure.
But this is a drug.

It’s much more complex than
calories in, calories out.

♪

♪

I’m Dr. Alexandra Sowa.

I have been practicing
obesity medicine

for over 10 years.

♪

I am author of
The Ozempic Revolution.

It is a revolution.

I don’t believe that there’s
been anything else

in my lifetime of practicing
medicine that’s

come out into the world
that has had...

such a big impact and
will continue to have

such a big impact.

The medication talks to
our brain, and it says,

"You don’t need to be
hungry all the time."

People will hear this
and say, "Well,

why can’t I just naturally
increase my native GLP-1?"

What’s very, very different
is that the native GLP-1

lasts at most...

a minute or two,

while the synthetic
version lasts

on a level of weeks.

We’re about to get to 50%
of the population

suffering from obesity.

And GLP-1 medications are
some of the most powerful

tools that we have to
treat the obesity epidemic.

♪

My name is Brian Murray.

I’m a registered
massage therapist.

I’m 39 years old.

I started my Ozempic journey
two, three months ago...

and it’s because my
blood sugar was un...

unbridled.
[laughing]

I was diagnosed with type 2
diabetes when I was 38.

The average person’s
blood sugar should be

about 5 to 7.

Once your blood sugar
hits about 10 to 15,

you enter stroke territory
and you can fall into

a diabetic coma
just for fun.

My blood sugar did end up
peaking at 27.9.

27 is bonkers high.
I’m walking sugar.

Like, this is crazy.
[laughing]

I had three or four different
medical professionals

literally look at me
and be like,

"How are you still alive?"

The good news with
the Ozempic for me,

is that it has completely
balanced my blood sugar,

like, it’s undeniable.

This morning,
my blood sugar is 5.4.

♪

So, every Tuesday at 10.30
is Ozempic day for me.

[chuckling]

Once you set the dosage,
you lift...

you inject, and then
you push

and hold the button.

It’ll click, click, click,
click, click when it’s going.

And you count to six....

SFX: [bell chimes]
Done.

♪

♪

[birds chirping]

My name is
Edna Sutherlen.

I’m a nurse.

In my 20s,
I was very skinny.

And you know all the
attention that you get

when you’re skinny,

and then suddenly
because of age,

now you start
gaining weight.

And then I went
through a divorce.

So, I got depressed,
and all I did was

eat and drink
and party.

I wanted to lose weight,
but I was feeling lazy,

not motivated
to work out...

and eat healthy.

Everyone was talking
about Ozempic,

and then suddenly
celebrities were looking

slimmer and skinnier.

And then I was like,
I’m gonna try it.

-Is that you?
-[laughing]

She was like,
"Where are you?

Is that you?"
[laughing]

Edna: When I heard
about Ozempic,

I thought it was
like a gift from God.

The heaviest I got
was 185 pounds.

And I’ve lost weight,

and now I’m 135 pounds.

Yeah.

Interviewer: So you’ve
lost 50 pounds?

Edna: Yes. I don’t
recognize that person.

That is not me.
[laughing]

Because I’m a nurse,
I know that

if I had diabetes and
they put me on it,

I’m going to have
to take it. So I’m like,

I’m going to take it for
weight loss then.

If it’s safe for somebody
who has diabetes,

then it should be
safe for me.

It’s a very tiny needle.

It doesn’t hurt, no.

I Googled online,
"Ozempic."

I got this clinic where you
put in your information,

they give you a
virtual consultation,

and then they mail you
the medication.

[laughs] Yeah.

Interviewer: So you
never saw a doctor?

Edna Sutherlen: No, ha.
Online, like virtually.

♪

Semaglutide, that’s
another name for Ozempic.

Dr Jason Fung:
There’s plenty of doctors

who are willing to make
money by handing out

these prescriptions
like candy.

You can do a five-minute
questionnaire online,

never having seen a doctor,
and some doctor will just

send you a prescription
for Ozempic.

Edna: Don’t come
stealing my Ozempic.

[laughing]

[birds chirping]

My name is Mike Israetel.

I am a sports scientist.

♪

I’ve been competing in
bodybuilding since 2013.

♪

I compete in untested
bodybuilding,

which means it’s a
free-for-all for

how many drugs
you can take.

We’re talking about
pretty liberal doses of

all sorts of drugs.
And so,

I’m kind of my own little
mini science experiment.

♪

In competitive
bodybuilding,

you’re judged on roughly
three criteria.

One is symmetry.

Another criteria
is muscle size.

The more jacked and heavier
you are and the more

billowing your pecs are,
the better.

But the last one and by far
the most important one for

winning shows is how
little body fat you have,

how lean you are, and the
only reliable way to

reduce body fat to its limit
low levels is to eat

substantially less food
than your body would want.

Your body was
engineered by evolution

to try not to get lean,

’cause typically
when you were lean,

that means you were gonna die
of starvation really soon.

So on your way down to
very low body fats in

bodybuilding, the hunger
turns from non-existent to

inconvenient to
driving you insane.

With Ozempic,
most people think like,

"Wow, this is awesome.

I don’t have to suffer
through hunger anymore."

You can get ultra,
ultra, ultra, ultra-lean

to your best ability
without hunger being

that really nasty factor.

Interviewer: So are you
taking Ozempic right now?

Mike: Yes, oh yes,
proudly and...

ever since I started
taking these drugs,

I’ve never come off.

It is the most radical
transformation that we’ve

seen in the pharmacology
of weight loss... ever.

Your ability to lose
weight can be

a test of your willpower.

Or you can take
the ---- pill.

♪

It is an enhancer.
It is a liberator.

But I want to ask you
the question...

Do you want to be a better
version of yourself?

Whatever that
means to you.

What if we had a
little bit of help?

I think help is
a good thing.

♪

I think more than 75% of
people who are overweight

will eventually try and
successfully integrate

these drugs into practice.
It just works.

There’s just no
other way to say it.

It just works.
It’s a miraculous feeling.

♪

♪

I’m Ben Greenfield.

I’m a coach, author,
speaker, podcaster.

I’m sometimes accused of
being a human guinea pig.

I prefer the term immersive
journalist because

it sounds more
professional.

♪

I did experiment with
injectable GLP-1s.

The reason that I tried
them is honestly

the reason that I do
a lot of stuff,

because I want to know what

what I’m talking
about feels like

when I’m interviewing
somebody on my podcast.

Trainer: That’s how we grow,
that’s how we get that...

Ben: So I took GLP-1s in a

microdose format
for a couple weeks,

one-tenth
of a normal dosage.

Starting off,
it controlled appetite...

shockingly well.

It went from mild appetite
suppression to a

complete lack of
desire to eat, period.

And, you get nauseous when
you’re trying to eat

the foods that
you normally like.

I would make myself
my beautiful,

glorious morning blueberry
coconut water smoothie.

And then just kind of
sit there staring at it,

asking why the heck I made
myself a smoothie.

And the other thing I
should mention is that

I had gastric upset.

I was alternating between
constipation and diarrhea

and, I think the biggest
takeaway for me was that

it seems like you can get
pretty good effects with

a smaller dose.

-Boom.
-There you go.

That’s for now, man,
good job.

Yeah.

♪

♪

At Nourish, we work
with clients

across the whole
food ecosystem.

The Ozempic effect is when
people don’t eat as much.

Their plate gets smaller.

We’re certainly seeing...

the "snackification,"
I would say, of foods.

We’re seeing snack size

actually becoming
the main course.

♪

One of the first signals we
got was Walmart in the U.S.

reporting on
consumers who were

shopping at Walmart

and also purchasing their
GLP-1 prescriptions

at the Walmart pharmacy.

And what they saw was
snack foods go down,

whole foods go up.

They are focused on
getting enough fiber,

getting enough nutrients,
getting enough protein.

Dr. Jason Fung: There have
been several studies

which show that people
eat far less junk food,

less of the snacks,
the salty snacks,

the sugary snacks.

They’re eating
more vegetables.

Indeed, those people
who take it

do change their diets
and seem to make

really good choices in
what they’re doing.

[kettle beeping]

Brian: I’m the type of
guy that I would get up,

go to the kitchen,
open the pantry,

open the fridge,
not hungry.

I’m just looking for
something to eat.

And now, for some reason,
I don’t want to do that.

It’s changed my snacking
almost completely.

One of my favourite things,
chocolate-covered almonds.

I love chocolate
-covered almonds.

Every day after work,
I would stop at the

grocery store and
buy a bag of candy.

Now with the Ozempic,
I don’t go in there.

I, I walk past.

My brain doesn’t say,
go in and get some.

I just, I just-
it’s invisible to me now.

♪

Dr. Sowa: GLP-1s allow us
to change

our entire relationship
with food.

What you crave,
what you want to eat.

It gives our brain
freedom from

constantly thinking
about eating.

It’s almost instant,
and it gives

tremendous power
back to the individual.

♪

Joanne: We’ve also been
tracking the obesity rate,

and it has been going up
basically since the 50s.

It’s basically
a hockey stick.

And this last year,
for the first time,

it stopped growing and
actually fell a little bit.

♪

So every calorie that they
eat has to count for more,

and the challenge for the
food industry is finding

their share within that
smaller plate size.

♪

Being on Ozempic, I actually
lost 35 pounds in a year.

♪

I would have a little
devil on this side,

a little angel
on this side.

The devil would say,
"Oh, you deserve it,

have the chips,
have the chocolate."

There’s not that voice going
on anymore saying like,

"Oh, it’s okay,
just eat it."

It’s like it just
completely disappeared.

Being in charge of such
a big operation here,

it does give you a
different view of the foods.

Our customer is
actually pretty vocal

when it comes to trends,

and that’s how I know
that trends are happening,

and that’s how we go and
do recipe development.

♪

Because we want to be the
leader in the industry.

The current trend that we’re
seeing is the GLP-1 trend.

Probably in the
next three months,

we will develop another
10 to 15 dishes

that will be
for that trend.

We are actually making
1,200 salads a day.

Bowls, where we do see
the popularity go up

on the bowls.
It’s very GLP-1 friendly.

GLP-1 recipes,
they are high in protein.

They are smaller portions.

We will gear towards that
feedback from the customer

’cause they’re
asking for it.

♪

♪

Edna: Ozempic doesn’t let
you eat fries, hamburgers.

If you bite it,
and you just-

feel like you
want to throw up.

You just can’t take it.

♪

So, I use honey
instead of sugar.

In the beginning,
I experienced constipation...

and then I’d read
about side effects,

where your gut gets paralyzed,
I was like, uh-oh-

[laughing]
My gut is paralyzed.

I took laxatives, and it
didn’t work, and I was like,

okay, this is how I die.
[laughing]

But then it started
working and...

SFX: [engine starting]

You lose maybe two pounds
every two weeks.

I’m just hoping that there are
no long-term side effects

because we are
kind of pioneers.

I plan to be
on it forever.

Ben: In the next
five to ten years,

I think a ton of people
are going to be on GLP-1s,

either at standard dosages
or at micro-dosages.

I think it will be probably
one of the most

popular drugs
of all time.

Thank you so much
for coming out.

[cheering & applauding]

♪

I am Dr. Melissa Hershberg.

Ozempic, it is a game
changer in medicine

for both diabetes
and weight loss.

All of a sudden, patients
would start to see ads like,

"Ozempic,
ask your doctor."

So people slowly started
coming in, saying,

"Okay, I’m asking
my doctor. What is this?"

And then,
it’s just blown up.

I remember 10 years ago
when I started doing Botox,

people would be, you know,
"Don’t tell anybody

I’m getting this done."

Fast forward 10 years,
everybody’s like,

"Yeah, yeah, I’m going
to my Botox appointment."

And I think we’re gonna see
the same thing with Ozempic.

When people started losing
so much weight on Ozempic,

phrases like Ozempic face and
Ozempic butt became popular.

All of a sudden
they look great.

They’ve lost weight.

But where did my
facial fullness go?

Where did my
perky butt go?

Because they’re
losing fat

in their face and
in their buttocks.

So, plastic surgery
is booming,

and I don’t think that
trend’s going anywhere.

♪

Dr. Sowa: What’s remarkable
about GLP-1 medications is

GLP-1 medications
seem to affect the

reward pathway
for not only food,

but also for drugs
and alcohol and...

some other
addictive behaviors.

That is the biggest thing
I see on these medications.

Their brain tells them
they don’t need it anymore.

[sirens]

♪

♪

I’m Dr. Greg Dillon.

I’m a psychiatrist in private
practice in New York.

The notion of GLP-1s

treating other compulsions
or addictions

that you might not be
aware of or might not see

is bearing out all
over the place.

♪

Gambling is so prevalent
because it’s thrown at us.

It’s on your phone.

There’s no question that
we’re facing this at

way huger numbers
than ever.

♪

Where these medications could
be really helpful is to...

derail that train car
for a minute

and to make them feel,

now it’s not really giving me
much of a rush at all.

Never mind,
why do it?

Dr. Hershberg: I think we’re
gonna see a lot more use of

this drug for things
like gambling,

sports betting,
porn addiction.

News: Porn.

It’s one of the world’s
fastest growing addictions,

and young men are by
far the most afflicted.

Dr. Dillon: Definitely the
interest and the use of porn

in young men seems
to be off the charts.

♪

Patients who’ve come in on
the GLP-1s for weight loss

have said that likely as
a result of the GLP-1s,

it doesn’t give me
the same rush,

it doesn’t give me
the same thrill.

They also no longer
have the craving.

So, having the opportunity
for medication

that might break that cycle

that you can’t otherwise break
could be really useful.

[indistinct crowd chatter]

♪

Dr Sowa: People drink a whole
heck of a lot less on these

medications and their
desire for alcohol...

diminishes or goes
away completely.

Joanne: The Ozempic
effect gets rid of

that reward centre
around alcohol,

so what we’re seeing
is people are

drinking a lot less.

So I could see
the alcohol industry

continuing to shrink
over time.

♪

♪

How’s it going? Good.

I’m Matt Johnston.

I’m CEO and co-founder
of Collective Arts.

♪

We’re a lifestyle
beverage company.

We’re all about creativity.

♪

Out of the site, we would do,
on an annual basis,

about 15 million cans.

♪

Cheers.

♪

That’s delicious.

My whole career has been
really about understanding

consumer needs and
those evolving trends.

The Ozempic effect,

I can’t think of another
trend that could cause

a category in the industry
of food and beverage

to go through
such rapid change.

But when you read reports
that are saying 60%

reduction in
alcohol consumption,

that’s pretty alarming.

And then you,
you apply that

to the percentage
of people that...

we expect will be
interested in these drugs...

it’s exponential.

♪

Luckily, we are
already leaning in on

health and wellness,

and we’ve really built a
whole side of our business

that is all about
those trends,

so I think we are nicely
ahead of the curve.

As you can see here,

this is our
non-alcoholic lineup.

Botany Elixirs,
we think,

are perfectly set up for
the GLP-1 trend.

They’re wellness beverages:
coconut water, fruit,

full of vitamins
and adaptogens.

And we have leaned into
the smaller cans

for more moderate
consumption.

♪

Dr. Sowa: We now have these
medications entering

stage two and three trials
for potentially using them

for the treatment of
alcohol and drug abuse.

So, I think that’s
very exciting.

♪

♪

♪

My name is
Susan Ruddie Spring,

and my business is
The Wedding Dresser.

My team is a collective
of fashion and

costume designers
and makers.

We do super fashion-y
Brooklyn brides.

We do very
traditional brides.

But our biggest draw
is the fact that

we can restyle and
resize dresses.

♪

We are seeing
many more brides

who are using weight
loss drugs and...

using them in a more
ferocious fashion.

♪

When someone has had a
really large weight loss,

rather than just
doing the normal,

which is taking in the
side seams of the dress,

we’re often taking
in the sides,

taking in the
centre back seams.

So we’re literally
taking the dress apart

at the seams and
repatterning it.

Ozempic weight loss causes
issues like loose skin,

saggy arms,
that kind of thing.

Brides are now trying
to hide their arms.

So we actually make something
called a mitt,

and this will give them
coverage so that

their loose skin
is tucked in.

Ozempic can lead
to loose breasts.

♪

We’ve always seen brides
lose some weight

during the process,

and they lose 5,
10, 15 pounds,

and most often
they lose that

like right before
the wedding.

But that’s a very different
kind of weight loss

than what happens
with Ozempic.

The brides tend to be losing
more like 35, 40 pounds.

I have heard of weight
losses up to 80 pounds.

We have perfected
taking in dresses

up to 10 inches
or more.

I communicate with a lot of
other bridal specialists and

bridal shop owners through
Facebook groups

and professional
organizations,

and I’m already hearing
of them being in crisis.

I see a world where...

if everybody’s on Ozempic,

there won’t be enough
humans in the world

to alter those dresses.

I think the crisis is going
to grow in the next few years

as more and more people are
able to access these drugs.

And because of being able
to access these drugs,

there’s more pressure
on brides to be thin.

♪

Dr. Sowa: Clothing is
definitely being affected.

My patients are either not
shopping because

they’re losing so much
weight that they don’t even

know what size
they’re in,

or they’re having to
shop continuously.

♪

♪

My name’s
Aileen Selkirk.

We are at Posh Boutique.

I’ve been in business
for 44 years.

Every 10 pounds basically

brings you down a size.

If you lose 10 pounds...

you’re gonna go
down one size.

If you lose 20 pounds,

you’re going down
another size.

So here we have
a large.

And here we have a
smaller size,

extra small, which
would be a size 4,

and that’s where this
seems to be going.

I started to look at numbers
the other night and from

last year to this year
in terms of sizing,

and we definitely sold
more smaller sizes

than we did the
previous year.

And we’ve sold more belts

in the past year
than we have sold

in probably five years
because women are

slimming down and they want
to show off their waist.

So belt sales,
I think,

are going to
increase even more.

♪

♪

I am Kelly Freeman.

I am Rory Lindo.

We are the owners of
Doll Factory by Damsels.

Rory: So we’ve found that,
you know,

if someone has lost a
substantial amount of weight,

they’re probably gonna
want to buy something new,

and we’re here for that.

We have dresses
of all sizes,

and they’re pretty,
they’re fun,

they’re lighthearted,
they’re whimsical.

Kelly: This is a romper,
and it has pockets.

This one is very pretty.

♪

On average, we’re seeing
maybe about two sizes

difference, and yeah,
it’s exciting for them.

Rory: Is it the
Ozempic effect? Maybe.

But what do they do with
all those old clothes?

So we even started a program
called Do It Again Dolls.

Kelly: It’s a whole thing
where we sell,

they get a store credit.

Rory: So it’s trading in
their old clothes

for new clothes.

Kelly: So it seems
to be a win-win.

It’s great for us, too.
Great for our community.

And great for people
with fluctuating sizes.

Rory: And great for
the environment.

Kelly: Yeah.

♪

If any industry can keep up,
the fashion industry,

we are like raccoons.
We will survive.

You know, pandemics,
recessions, whatever,

size changes,
you know,

we’re willing to
go with the flow.

Rory: Yeah, we’re adaptable.
Kelly: Yeah.

♪

Dr. Sowa: I just saw
a patient last week

who was like,

"I have $10,000 worth
of suits in my closet,

and I took them
to the tailor,

and they said I’ve lost
so much weight

that he can’t even
take them in."

♪ [faint crowd chatter] ♪

♪

I’m Shawn Wells.
I’m a biochemist.

♪

I really feel like there’s
room for the GLP-1s.

It’s a fascinating
mechanism.

But I would like less
of a cowboy approach,

a populational approach.

Let’s take the
great experiment.

Let’s do it in big doses.

♪

One scary effect
that we’re seeing

is that these people are
losing weight

faster than ever before,
but they’re also losing

a disproportionate
amount of muscle.

They’re also
losing more bone.

When we’re losing
a lot of muscle,

we tend to lose a
lot of bone as well.

Joanne: A big issue with
this is you’ll be healthier

in some ways
but not in others.

And, you know, muscle is
the number one thing

in terms of longevity
as we get older to

protect ourselves from
falling, breaking hips.

Dr. Sowa: Longevity is
about strength, right?

You need to be able to get
out of a chair easily

when you’re 85,
90 years old.

Joanne: I’ve been looking at
some studies that show

that gym memberships
actually go down

when people are
on these drugs

and have successfully
lost weight.

We’re people who
like shortcuts,

who like comfort.

And so, if there’s
a shortcut and

you don’t need
to go to the gym,

that seems to be what a
number of people are doing.

♪

♪

We’re about 1,500-plus
studios, 68 countries,

and we’re
continuing to grow.

♪

I’m Tom Dowd,
and I’m the CEO of F45.

Is Ozempic a
magic pill?

I think the answer
is gonna be no,

simply because you
have to work out

and not lose
muscle mass

because muscle mass
is a longevity pill.

The concern is that
when folks go on GLP-1s,

they’re eating less
calories in total.

It’s critical for anyone
using these drugs to be

consuming enough protein,

consuming the right type
of nutrition, and also,

of course,
strength training.

Dr. Sowa: Part of
my work with patients

is saying,
"Hey, I get it.

You need to reframe your
relationship with the gym

that this isn’t about
weight loss now.

This is about longevity,
strength,

and overall health."

Joanne: Sarcopenia,
which is the loss of muscle,

happens naturally
as we age,

so if you have that coupled
with these GLP-1 drugs,

we could be in
for a real crisis,

a lot of seniors falling
and breaking things

later in life.

♪

Tom: We’re finding out that
a lot of our members

are actually taking it.

They weren’t really
talking about it.

So, for us, we embraced it
because we want people

who are on it
not to hide it.

We started offering it
to our membership base.

So if you want to go on
Ozempic or any other

GLP-1 drug through F45,

you have to go through
a Teladoc service.

So, just like any
other doctor visit,

you have to go through
the same process with us.

♪

I think it’s definitely
gonna grow as more people

see other people
with the results and

losing weight and
working out more...

which is great for us.

♪

♪

My name is
Peter Lund Madsen,

and we are in the centre
of Copenhagen.

This city has changed
a lot since the 90s

because everyone has gotten

much more wealthy
in Denmark.

There’s a lot of cafes,
there’s a lot of people.

Ozempic has also a
part to play in this.

♪

♪

We have in Denmark a
very, very big company.

Novo Nordisk is very
important for the

financial growth
in Denmark.

If it hadn’t been
for Novo Nordisk,

we would not have had
growth the last two years.

So it’s a very,
very important

economical factor
for Denmark.

Dr. Sowa: I’ve had
a few patients who,

as soon as I put them on
this medication years ago,

they immediately went and
invested in the companies

because they knew that
nothing in their lifetime of

60, 70 years had
worked like this.

♪

My name is
Jens Juul Holst.

I am a professor of
medical physiology

at the University
of Copenhagen.

We found GLP-1 here
in this laboratory.

♪

This is really where
it all happens,

where we are doing the
analyses for the hormones.

We’re doing a lot of
experiments to understand

the secretion of GLP-1.

So that’s what’s
going on here.

♪

All of this really
started in ’72, ’73.

So it was
extremely exciting.

But eventually,
Novo Nordisk

began working on this.

And, therefore, potentially
could do something

about obesity and the
complications of obesity.

That’s when,
you know,

the public became
aware of this.

♪

Peter: The molecule behind
Ozempic was created and

invented by Novo Nordisk
and Danish scientists.

And the way it
happened is miraculous.

As it looks now, you have
to take this drug

for the rest of your life.

So, it is a drug
that will carry

an enormous demand
in the future.

I think that in 5,
10 years, there will be

so many people in
the Western world,

in the total world,
who will be on this drug

or who would want to be
on this drug.

A lot of big, big problems
can be solved, maybe,

by this single molecule.

♪

Shawn: And so, when we
look at our population,

we have 93%
metabolic dysfunction,

meaning our metabolism
isn’t functioning optimally.

We’re aging faster
biologically

than chronologically.

The majority of all diseases
are not genetic in nature,

but metabolic in nature.

Cancer, Parkinson’s,
coronary heart disease.

[sirens]

We’re actually heading
towards type 3 diabetes,

which is diabetes
of the brain,

which is also known
as Alzheimer’s.

And that number
is rising.

Dr. Sowa: There are a few
mechanisms that are leading

to such a profound health
benefit from GLP-1s.

So we are seeing improvement
in cardiovascular outcomes,

kidney outcomes.

We are decreasing all
sorts of inflammation,

and dysregulation,
and leads to disease.

♪

♪

My name’s Daniel Drucker,

and I’ve been
working on GLP-1,

which is the science
that supported the

development of
drugs like Ozempic.

I’ve been working
for about 40 years.

♪

What’s really caught
everyone’s attention

are the effects beyond
blood sugar control,

beyond weight loss.

Personally, I have a
family history of

Alzheimer’s disease,
as do many people,

and it’s fascinating to me
that perhaps the drugs

might benefit people at risk
for Alzheimer’s so,

we’re certainly spending a
lot of time and effort

trying to figure out
how that works.

We look at inflammation,
for example.

How does GLP-1 talk to
the immune system

to reduce inflammation
and make people with

arthritis or metabolic liver
disease feel healthier?

Is that directly talking
to the immune system?

We have people telling us
that they feel better,

and they have
less brain fog,

and their arthritis is better
after just one injection.

For example,
rheumatoid arthritis.

This is the same hand from
the same individual

now remarkably improved.

So we strongly suspect
that GLP-1

is reducing inflammation
independent of

its effects on
body weight.

♪

Jens: We can see now
that it has

very powerful effects
on inflammation.

Okay, we dampen
inflammation,

and we have
beneficial actions on

the blood vessels,
where the risk of

developing dementia with
a GLP-1 reduces the

occurrence of dementia
by 50%,

as much as that.

Dr. Drucker: I think the
greatest additional benefit

is the reduction
of heart disease so,

reduction of
heart attacks, strokes,

cardiovascular death,
reducing the rate of dying

is obviously
extremely important.

Dr. Sowa: And what we are
seeing is that by improving

metabolic health with
these medications,

we’re decreasing a
whole host of diseases.

16 types of cancer,
cardiovascular disease,

dementia,
Alzheimer’s.

Dr. Drucker: And that’s
really taken us all

by surprise, and it’s
pretty exciting.

♪

♪

[laughing]

Lauren: Come with me!

This is New York Comedy Club,
Upper West Side.

My name is
Lauren Hope Krass.

I’m a body positive and
fat liberationist...

stand-up comedian,
podcaster.

And give it up right now
for Lauren Hope Krass.

-Hey!
-[cheering]

Lauren: Thank you!

[singing]
Oh, oh, oh!

Ozempic.
[laughing]

Like, it would just
like be in your head.

I’m like, what is that?

Fat people in summer,
we do not get along,

okay, we are
mortal enemies.

Superman has kryptonite.

Fat people,
we have Fahrenheit.

[laughing]

I think my issue
was just with like

the mass
marketing of like,

"Everybody take this.

If you’re fat,
you have a disease.

You have to take this."

You know,
it’s like, no, I don’t.

No, I don’t.

I mean,
people are saying it.

They’re saying
heroin chic is back

and you’re seeing it.

Body positivity is
no longer trending,

which is terrifying.

Like, everyone
is shrinking.

Hello and welcome
to Belly Laughs.

This is your host,
Lauren Hope Krass.

And today we’re gonna
be talking about,

you guessed it...
GLP-1s.

What you’re talking about is
eradicating a demographic.

It’s so freaking
stigmatizing and scary.

It’s like, oh, now that
there is a proven way

to keep weight off,

I’m walking around in the
world as a fat person,

and I’ve got other people
looking at me like,

"You know, you don’t
have to be like that?"

And it’s like,
I know.

Fast forward five years,

and if half the country
is walking around...

skinny and on
their GLP-1s...

the microscope on fat people
is gonna be even harsher.

And that’s where I come in
to try to cut through

that anti-fat bias
and to say,

fat people can do lots
of amazing things.

And so, I love to interview
plus size people

on the street and
ask them like,

"How did you
find this outfit?

What crazy hoops did you
have to go through

to like look this cute?"

Hello, and welcome to another
episode of Fat Fashion

with me, your host,
Lauren Hope Krass.

Alexis, tell me
about this beautiful,

floral winter jacket.
Slay.

We got a twirl!
It’s fabulous.

Alexis: I like an
oversize glasses.

I usually do big hoops.

Today we’re
doing medium.

Lauren: My message for
fat people is, like,

you can do
hot girl shit.

You know, like,
you don’t have to...

spend the rest of
your life trying to

shrink yourself into an
impossible box.

Anyway, sorry, I’m getting,
like, emotional,

but it’s fine.

If you want to take Ozempic,
it’s okay, girl.

It’s okay.

[laughing]

But, like, it just,
it makes me sad, like...

People are getting some
issues that, you know,

it’s going to affect them
for the rest of their lives.

And they go, "Oh,
you’re fat, here’s a GLP-1,"

and then they send you
on your way.

♪

If half of the world
is on Ozempic,

it’s gonna be boring.

Going to restaurants,
going to parties,

get a little Ozempic-sized
birthday cake.

♪

♪

Joanne: We’re seeing that
people on these drugs

are not going out to
restaurants as much.

I think it’s kind
of sad, myself.

I think, you know,
there’s the joy in food is-

and the sharing, like,

we connect as a
species over food.

But I do see that a lot
of people on these drugs,

they’re actually taking
themselves out of

those social situations.

Dr. Fung: So imagine that
you’re taking this drug now

where you simply don’t
get any enjoyment

from your food.

That’s great because
you’re losing weight.

But what about if you’re
going to a big wedding?

Or it’s Thanksgiving
or it’s Christmas?

As it goes on,
month after month of this,

where you’re just not
enjoying your food anymore...

I think it gets a
little bit wearing.

♪

Shawn: So the great
experiment is on.

I see half the population
being on GLP-1s.

I do see that
going over 50%.

Maybe 93% of the population
that’s metabolically

dysfunctional will be
forced to have it.

♪

Dr. Sowa: It’s my real hope
that these medications start

to free us from this pattern
where we have just gotten

heavier and heavier and
unhealthier and unhealthier.

♪

Brian: The Ozempic
I would definitely say

is most likely a life saver.

♪

Edna: After you
lose weight, you realize

you gain a lot back.

You gain your happiness back,
your confidence back.

Dr. Hershberg: People still
have to remember that

this is a drug, this is
a pharmaceutical drug.

You have to use it
in the proper dose.

Dr. Sowa: I do not
hope for a world in

a few generations where
everyone’s on this shot.

Even though I love
these drugs,

and I think that they
are true miracle workers,

I do not want everyone
to have to be on them.

Shawn: It’s hard to say what
the downstream effects

of all of this are.

I’m not saying that
GLP-1s are bad.

I’m saying that
we need more data.

Everything is just
happening in real time

on a massive level.

We are the great
experiment.

♪

♪

♪

♪

♪

♪