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There are about 37 trillion cells within the human body.

Each cell type has its own unique role.

For example, oxygen transport is the job of red blood cells.

White blood cells fight harmful invaders.

Day in, day out, their hard work and cooperation

is what allows us humans to thrive.

This is the land of red bone marrow

where blood cells are born and raised.

RED BONE MARROW

It's their true heartland.

Blood cells are created by hematopoietic stem cells

and are then separated by type.

Here, those born as progenitor cells

are being nurtured into erythroblasts

under the care of macrophages.

Here you are.

Thank you.

Huh?

Where am I?

Miss Macrophage?

Kiddo…

Why are you wandering around?

Oh, deary me…

I…

STREPTOCOCCUS PYOGENES

…just love to pick on little blood cells!

Antigen detected!

You think a baby white blood cell can lay a finger on me?

I'll protect you.

MYELOCYTE

I'm gonna be a worthy white blood cell!

Big Brother!

Pushy brats like you…

I detest!

WHITE BLOOD CELL

It's all over now.

Good, I was worried about you.

Miss Macrophage…

Oh, dear… don't cry.

Let's head back.

Congratulations on your enucleation.

ENUCLEATION CEREMONY

Today, you become official red blood cells

taking oxygen from the lungs to deliver throughout the body.

Enucleated at last.

No more getting lost. Focus on your mission.

Yes.

I vow to be a worthy red blood cell.

Dad.

Wake up. It's time!

Heck…

You gotta get up, now.

Come on, get up.

Disgusting.

Get up, I mean it.

Thanks for this.

What the hell?

Scrambled tofu.

It's low calorie and it's healthy.

Who needs healthy? I want eggs.

FOLLOW-UP TESTS ADVISED

Blood pressure, blood sugar, uric acid, cholesterol.

All in the red. Don't try to hide it.

"Follow-up and diet evaluation needed."

Feels partly my fault…

"Fecal blood detected"? Sounds scary.

That one's fine. Just a bleeding hemorrhoid.

It's not funny. Go back to the clinic.

Yep, okay…

See you later!

Deliver CO2 to the lungs…

Pick up oxygen then deliver it around the body.

I'll be fine. I've got this.

Let's go.

Heck…

-You're in the way! -Sorry

Keep your eyes open.

Here it is!

These are the correct veins…

You're going the wrong way.

Sorry!

Really? How come?

Run away!

We're in!

From today, we lay claim to this land.

STAPHYLOCOCCUS AUREUS

Death to anyone who gets in our way.

WHITE BLOOD CELL

I'll protect you.

Who do we have here?

A nice little snack for me.

White blood cell U1146, neutrophil unit.

Invading bacteria exterminated.

Big Brother…

Thank you for helping me…

I'll grow up to be a worthy red blood cell.

It's a promise.

What are you looking at?

Nothing.

You helped me and I'm grateful.

Don't thank me, it's my job.

But, anyway…

You're welcome.

Sure.

I'm a killing machine.

I'll kill every one of 'em.

That's a white blood cell.

-Scary guy. -They're merciless.

Maybe it wasn't him…

Helper T-cell HQ here.

We hear pneumococcal bacteria are on the loose.

We're dispatching killer T-cells.

Which T-cell is which?

Helper T-cells.

Guide to Cells.

When us macrophages discover a viral or bacterial intrusion,

we alert helper T's who make strategy and order killer T's into battle.

Killer T-cells…

They target viral or bacterial infections.

You can count on them to dive straight in.

-Don't slack the pace! -Yes, sir!

Listen up. You get two seconds per invader.

Slack off and you're sent to the spleen, never to return!

Yes, sir!

Those are killer T-cells, huh?

This is bad. They need killing before they replicate.

Keep an eye out.

Pneumococcus targets nutrient-rich red blood cells like you.

I'm about to head to the lungs…

If left unchecked, pneumococcus attacks each organ

and ultimately destroy the entire body.

Destroy it?

Wait a second.

Don't leave me!

The lungs.

In this organ oxygen is pulled from the air

and CO2 from within the body is released.

Here we are in the lungs.

This is amazing.

My receptor is responding.

What's that?

It's a radar that detects bacteria.

They're close by.

Where? Let me at 'em!

Weren't there better designs for that?

Something's real close.

I'll keep patrolling.

I'll go get some oxygen.

That's a bronchial tube.

Sorry about that.

She's pretty clueless.

Here at last.

An alveolus.

Where CO2 from the capillaries is exchanged for O2 from the air.

Okay, time for the gas exchange.

STREPTOCOCCUS PNEUMONIAE

Thank you for sneaking me in here.

It's the perfect spot to lay in wait for those red blood cells.

As an appetizer…

I'll start with you.

Mr. White Blood Cell?

My receptor went quiet when you left.

I never imagined you had a stowaway.

How come you're here?

You didn't do your homework.

We white blood cells are "floaters" who can slip through vein walls.

Think I've come this far to give up without a fight?

Let's run.

Come back!

Such feeble attempts at escape.

You're pathetic.

Back up a little.

What's up, Mr. White Blood Cell?

Ready to give up?

It's the end of the road for you.

Time to die!

It's you who's reached his end.

What's this? What's happening?

Bacterial capture completed.

Now starting elimination process.

What the hell's going on?

Let's get a cup of tea.

Hey, let me out!

It's no use. That capsule is unbreachable.

Besides, we're in the bronchi and you know what that means…

Whatever, just let me go!

Where are you going?

Do you want some?

Sure…

Put me down! What's going on?

Let me go.

Where are they taking him?

Like I said, we're in the bronchi.

Where am I going? Let me go.

What's going on?

SNEEZE NO. 1

Sneeze?

Beginning countdown.

Three.

Two.

One.

Zero.

What's happening? Stop this!

Bye-bye, bacterium.

CELLS AT WORK!

Good morning… Senpai.

Good morning, Niko.

-Math class now? -Yes.

-Let's study hard. -Yes.

See you.

Emergency announcement!

Adrenaline rush!

We're losing control.

Dopamine, endorphins.

Secretion sequence engaged!

ADRENALINE, DOPAMINE, ENDORPHINS

Get the party started!

Let's get wild!

It's out of control.

Feel that great adrenaline rush!

This is useless.

Are you okay, Niko?

I'm fine.

That must hurt.

Mr. White Blood Cell.

So, we meet again.

-What's all this? -As you can see…

An external blow ruptured the vessel's outer walls.

Blood then flows outward.

In other words, we got us a scrape.

A scrape…

If you fall through, you leave our world forever.

That's terrible.

What's worse,

if not sealed quickly, intruders can get in.

Something must be done quick.

Not to worry.

A team to fix this should be here any sec.

Look over there.

Those kids?

Take it slow.

Watch your step, everyone.

Platelets, you're here.

Reporting for duty.

Reporting for duty.

Platelets are another cellular component of blood.

If a blood vessel's damaged, they congregate to close the wound.

Everyone ready?

Yes.

You all brought your fibrin?

Yes, we have!

Okay, here we go!

Yes!

-Big Sis, move aside. -Sorry.

Let's link up the fibrin using our coagulation factor.

Mind you don't fall.

All together now…

Let's go!

The blood clot.

Coagulation factor is a blood protein which acts

to create a fibrin network that solidifies the platelets into a clot.

Blood clot completed!

Complete!

Impressive, huh, Mr. White Blood Cell?

Mr. White Blood Cell?

Everyone, join in, please.

Mr. White Blood Cell?

Where are you?

Are you okay?

Big Sis too.

Sorry about this…

Seems like I'm stuck…

When a blood vessel is compromised

and awaiting completion of the repair,

we blood cells are also used to block the hole.

This is called a secondary blood clot.

How long do we stay like this?

Who knows?

At least until things dry and form a scab.

Boss, thanks for treating us last night.

I hear your daughter's making your bentos.

Says it's for my health. Not enough food, though.

She's a good girl. Mine won't give me the time of day.

It's ready.

Eating that too?

Such a tiny bento is not enough fuel for me.

So much for Niko's hard work for your health…

Boss, drinking again tonight?

We went yesterday. He's terrible, eh?

Are you boozing every day?

We declare a CO2 alert.

Toxic substances are in the bloodstream.

All cells, take care on your daily rounds.

Fatigue buildup, lack of sleep.

Over-indulgence!

This body is being stressed beyond limits.

It runs the risk of oxygen deprivation.

You must not rest. Keep that oxygen flowing!

All cells, do your utmost!

Yes, sir!

Open up the aortic valve.

SEVEN FUNGI

DON'T PITY ME - GIVE ME OXYGEN

Hurry.

Mr. Red Blood Cell, you're not bringing enough oxygen!

Sorry, orders are to prioritize the major organs.

So we extremities are expected to just die?

Forgive me. It's an order from above.

-We gotta go. -Come back here!

I ain't finished with you!

Don't keep apologizing. It's an endless task, Newbie.

-Yes, sir… -You bastards!

Get us more oxygen now!

Sorry, sir. I'll get right on it!

You jerk! Now you got me apologizing.

I'm sorry.

That's dangerous.

What's this obstruction?

LDL?

Illegally-dumped cholesterol, huh?

Any more of this and we'll get hardened arteries.

Let's go another way.

What's this?

Relax, it's just alcohol.

Alcohol?

Damn, that hit the spot.

I'll have the liver and tripe.

This is bad. Got to get outta here.

Or we'll spread this stuff everywhere.

It's alcohol for sure…

Uh-oh…

I feel dizzy…

Come with me. I'll show you a secret.

The liver.

This organ is the body's chemical factory.

It synthesizes, detoxifies and excretes a myriad of substances.

You're having a hard time.

Just drink this.

Sure.

This is…?

It breaks down alcohol.

The enzyme ADH.

Enzyme ADH?

It breaks down blood alcohol and gets rid of it.

That's the job of these liver cells.

HEPATOCYTES

Cheer up. We're here to have fun.

Or shall I help you drink?

Is this body able to survive?

The blood vessels are wrecked and barely passable…

Our bosses yell about oxygen quotas but don't give a damn about us.

If someone doesn't fix this terrible work environment…

His time's up.

At the end of your lifespan Kupffer cells gobble you up

and you're just nutrients for someone else.

That's the fate of the red blood cell.

We just carry oxygen until we croak.

It's pitiful…

But don't worry.

If anything should happen… I'll be there for you.

We work so diligently

only to end up like that…

I can't stand it!

Newbie!

He's not wrong…

Unless the body changes course, neither will our fate.

We remain as doomed as ever.

But who's really to blame?

Thanks for helping me today.

Maybe we should go out some time?

No way, it's weird to invite him out of the blue.

Heck!

MAYBE WE SHOULD GO OUT SOME TI…

I've done it now…

Sure.

Seriously?

Thank you!

When?

Okay…

How about next Sunday?

Got it.

Great!

I got a date with Senpai!

I'm feeling cold.

Do I have a fever?

Huh?

This isn't the right place…

I got lost again.

TO THE EPIDERMIS

I'll grow up to be a worthy red blood cell.

It's a promise.

All right…

Excuse me, I'm searching for the kidneys.

CELL

Your swing's too big.

Enough for today.

These front-line fighters are impressive, eh?

Do your best to be like 'em.

Yes.

Damn it…

You're a feisty kid.

Someday…

I'll be a strong white blood cell just like you!

I'll be waiting for you.

Thank you, Big Bro.

Just like you at that age.

Macrophage, calling.

Type B influenza viruses on the loose.

Roger. Mobilizing killer T-cells.

Viruses multiply way faster than bacteria so watch out!

Yes, sir!

Killer T, are you my back-up?

We'll save the day. You guys stand down.

You're all too late.

NK, you bastard…

How dare you steal our glory?

Quiet.

Such a fragile ego.

NK CELL

Your little soldiers can't even deploy without orders from the helper T's.

How dare you?

You only fight in groups, right?

Whereas I can roam wherever I please.

I'm a natural born killer.

A natural killer… an esteemed NK cell.

Natural-born my ass.

You're still a narcissistic jerk, like always.

Say that once more.

It's no time to argue. Look.

Here they come.

Out of my way.

I can handle this all by myself.

She can't get all the credit. Let's go!

Let's go!

Red Blood Cell, stay back.

Yes.

-Ready to do it? -Yes, sir!

You're in the way. Get lost.

Sorry…

OXYGEN

NASAL CAVITY

I never knew about this place.

It's called the nasal cavity.

Produces a liter of mucus per day.

Which makes the nose run

washing away dust, mold and viruses.

It's warm…

What's wrong?

You're looking kinda down.

I'm so envious of you all.

Everyone's got a different role.

Fighting so hard to protect the body.

So cool…

Then there's me…

limited to only carrying oxygen.

I keep losing my way…

Yet I'd vowed to be a worthy red blood cell.

Don't think like that.

We patrol the streets and locate the enemy.

Macrophages provide the intel on them.

Helper T-cells can then make the strategy.

Killer T-cells come along, then together we deal with the enemy.

We each take pride in our own role.

And you're a part of that team.

We can't do what we do

without your constant supply of oxygen.

We're in it together.

We're a team within this one body.

So…

You're doing great.

Thank you very much.

Well…

You're welcome.

Senpai, good morning.

-Morning. -Sorry for the wait.

It's fine. Shall we go?

Sure.

Feeling okay? I heard it was flu.

I'm totally fine. Couldn't be better.

That's good.

Yay, it's our first date.

We're in love! Let's kick it into gear.

Niko dating, eh? She's at that age.

Hope he's not a weirdo. See ya.

Thanks for coming in. Take these.

-Thanks. See you later. -See you.

We're so in love!

C'mon, jump y'all.

Let's party!

It's lovely… the way it sparkles.

Haven't been here in a while.

-Really? -Yes.

In the old days, when school was out,

I'd love it when Mom brought me here.

I guess you've outgrown that, huh?

I'd still come with her if I could.

She died. When I was nine, of an illness.

I had no idea…

So, that's why you want to study medicine?

Yes.

Mom knitted this for me in hospital.

But she had to give up.

See, here?

The stitches are all crap and don't line up.

Dad insisted on finishing Mom's present.

So he did the last bit.

That's why it means so much.

You're so much more mature than me.

Not really…

I'll never give up

And I'll never back down

I know in my heart I'll never be defeated

Uh-oh…

Listen, life is for the living.

THE ANUS

We're designed to be the body's strongest muscle.

Hold tight 'til the brain orders otherwise.

Don't flinch and let slip.

You will resist internal muscle pressure.

We're in charge. Take pride and hold fast.

No poop shall pass!

EXTERNAL ANUS

Focus your power and hold tight.

Hi guys, I'm here with some oxygen.

Excuse me.

Just leave it here.

This is a dangerous zone.

Newbie, I don't want to lose you.

My last time here was a nightmare.

Our timing couldn't have been worse. We lost a bunch of guys…

-Senpai, are you okay? -Yeah.

Testicles next. Let's go.

Don't tell me it's happening again?

Newbie, this ain't good.

Rectal pressure is increasing. Commence defecation countdown.

"Defecation"?

Clear the way!

It's a poop. He's going to poop!

Poop?

INTERNAL ANAL SPHINCTER

-A manly stink! -Let us be free!

Hold on.

Just hold on.

We'll be collateral damage. Let's escape!

Emergency! Emergency! Immediate defecation shutdown.

Block the anus!

Heck, we've got to run, Newbie.

What's going on?

The brain ordered an override.

Senpai!

It's leaking…

No… I'll never give up.

You gotta be kidding…

Not one speck must pass!

Please, I'm begging you.

It stinks…

Disgusting. What did he eat that ends up so bad?

More pressure, boys. We're slipping!

What's happening? The brain's saying stop, right?

The damn internal anal sphincter.

Let go! Why are you blocking us?

They're not under cerebral control.

If the stool comes this far, they just automatically push it.

They're simple guys.

Heck, they're breaking through.

If we don't hold fast, we'll flow with them.

Push back!

They're gone.

Is that a leak?

No, a burst hemorrhoid.

Hemorrhoid?

How much more will this body torture us?

Go ahead…

I'm done for…

I can't go on.

Hold tight, Newbie!

Open the gate, open the gate!

Anus open!

Newbie!

Senpai!

Are you okay, Newbie?

Yes.

I promised, right?

If anything happens, I'll be there!

Senpai…

Let's escape and go make our next delivery.

Let's head to the testicles together.

Oh, no!

A second wave…

Open up again!

Senpai.

Don't let go, hold on!

Don't let me go.

I won't!

Let it flow!

But…

what about our trip to the testicles…

Senpai!

Newbie!

I didn't give in.

Thank you very much for today.

It was my pleasure.

Senpai…

Well…

I…

I had a great time today…

Thank you so much.

See you at school.

Niko!

Please…

would you be my girlfriend?

Yes!

If you don't mind.

You mean it?

Fantastic.

Thank you.

I'm really happy.

Thank you.

-I'm grateful. -Same here.

I should take this.

Yes?

SANSEI TRANSPORT INC

Dad.

What's up?

Your boss told me you collapsed.

Hell of a shock…

I was in the toilet, got dizzy then collapsed.

Doc says my bad lifestyle's finally taking its toll.

You didn't go to the follow-up?

Guess not…

"Guess not"? You gotta look after your health!

My bad.

Are you Niko's boyfriend?

Can we talk?

Sorry for today. I'm going to bed.

Are you okay?

Check this out.

They found it in his truck.

Your dad's so proud of you.

Always talking about you at work.

He knows that you're smart enough for medical school.

TUITION PLAN FOR MEDICAL SCHOOL

He asked for more work to pay for tuition.

Apparently he begged his boss.

That's why he was working on his day off.

Come with me a minute.

It's been 14 days since your creation.

Your peers are developing into myelocytes.

But your growth has stopped at an immature stage.

Soon you'll lose the ability to specialize.

Abnormal blood cells like you can go on to replicate uncontrollably

and impair the production of proper blood cells.

You're saying we're abnormal?

Sorry, but you're no longer needed. You'll be disposed of.

What the…

Take 'em away.

Stop!

I don't wanna go!

You too.

No, I'm gonna be a worthy white blood cell!

Catch him.

You can't run.

Come on, let's go.

Why? Why me?

Why me?

Why me for hell's sake?

What's happening?

ONE MONTH LATER

Thank you for the food. Heck, gotta go!

I'll take less rice from now on.

At the clinic, all my test results have improved.

It's all about food intake.

Good boy, I'll serve you less then.

Here's your bento. You do the dishes.

Okay.

What's up with your leg?

No idea. I must've bumped it.

I'm off.

Sorry for the wait. Please sign for the oxygen.

You're always on time, thank you.

Of course, that's my job.

-I'll be back soon. -I appreciate it.

Great, I did my route without getting lost.

WHITE BLOOD CELL

More reliable by the day…

Okay.

Mr. White Blood Cell?

Are you okay? I'm sorry.

I'm fine.

My head was in the clouds.

The platelets?

Hey, Big Bro and Big Sis.

Have you seen the rest of our gang?

Don't think so. You?

No, me neither.

What's wrong?

We can't get everyone together so that bruise won't heal.

I see. I wonder what's going on…

Hope they're not lost…

Are you alone?

It's strange.

Not many of you white blood cells around recently.

Niko…

Senpai, good morning.

Are you okay?

What's wrong?

Niko, are you okay?

As for a plan of treatment,

let's talk after I've seen further tests.

At the moment, the low platelet-count means she's prone to bleeding.

To begin treatment, she'll first need a blood transfusion.

Sir?

Are you okay?

Yes…

I owe her so much.

She rescued me from ill-health. So I'm sure she'll get well too.

Doctor.

If there's anything I can do, I'll do it.

Please help her, I beg you.

Please…

Leukemia?

It's acute myeloid leukemia, apparently.

Blood contains red and white blood cells and platelets, right?

You've got some ugly-looking bastards growing among yours.

And?

What'll happen to me?

Well…

Do nothing, the good guys get scarce which is not okay.

So… you know.

They treat it with medicine.

Chemotherapy, you know.

But it's, you know…

It's gonna be fine. Right?

I'm sure it'll be fine.

Why?

Why isn't it me?

Why her?

Why?

Why not me?

Heck, this is impossible.

You're so bad at that.

Shut up. Get better and finish it yourself.

Hi, Mom!

Mom, listen, I got elected to the sports day committee.

Congratulations. That's great.

-Isn't it amazing? -Yes, really amazing.

Ma'am, are you okay?

Yuko, hold on. Yuko.

Mom.

Vasopressors, quick.

Yuko!

Mom.

Mom.

Mom.

Looking for blood donations.

Can anyone spare the time?

Types A and O especially welcome.

Walk right in, no waiting.

Look, the roads are paved at last.

It's finally getting livable.

What's that?

REMAINING BLOOD DRAW AMOUNT

Oxygen, here. Get well soon.

Gimme some.

I'll be right there.

Over here. Me too.

Here…

Me too!

Oxygen, quick!

Leukemia cells are on the increase.

Please be careful.

Reinforcements are here.

Thank you.

Red Blood Cell, are you okay?

I'm okay. We'll make sure oxygen gets through.

I'm counting on you.

Okay, everyone. Do you have oxygen?

Yes.

What's going on?

Deliveries first, then I'll explain.

Oxygen's arrived.

Leukemia cells could be lurking anywhere. Don't drop your guard!

Yes, sir!

You're so damn loud. You'll scare off the enemy.

You're too damn proud!

Shut up.

Pathetic little boys who can only fight in groups.

How dare you?!

Quiet, guys.

Something's coming…

Long time, no see.

Big Bro.

Someday I'll be a strong white blood cell just like you!

You're that little kid?

I'll be waiting for you.

Thank you, Big Bro.

Were you waiting for me?

Big Bro.

Fight me again. See how strong I've become.

I'll take you, bug bastard. Bring it on!

Who the hell are you?

This is about me and him.

Reports coming in of overwhelming leukemia cell increase.

They're laying siege to the spleen and lungs.

Lymph nodes have fallen and other organs are under assault.

Mobilizing all killer T-cells.

It's no use.

We can multiply endlessly.

No matter how many you kill.

That's enough.

You're crazy. For all your strength, you can't support this body.

Why?

Why do you have to say that?

You've been waiting for me, right?

Let's fight.

See if I've gotten stronger.

Forgive me.

My duty is…

Don't tell me you think I'm defective too?

If so, I'll have to kill you.

Leukemia cells now reported in the red bone marrow.

All hands, get there quick!

That's bad.

The bone marrow's where we blood cells are made.

If that falls, we got no back-up.

Let's hurry.

Next we gotta go to the intestines.

Hold up. Can we take a break?

No time to rest.

Cells are weakening. We have to help.

Okay.

What? What the hell happened here?

It's them.

They're destroying the cancer cells,

but also killing us regular cells in the process.

Anti-cancer agent?

Watch out!

NK!

I'm okay.

Look over there.

Still so many…

The missiles don't seem to bother them.

LEUKEMIA CELLS

Heck, where do they keep coming from?

ANTI-CANCER AGENT

Are you okay?

Get me some water, kid.

Yes.

Sorry.

I'm sorry.

Why? Nothing to apologize for.

Sorry.

Want some water?

Thanks.

NK! Are you okay?

Here they come again.

This is endless.

We're short of oxygen too.

Where are the damn red blood cells?

We're gonna be wiped out.

We can count on those guys.

They'll get the oxygen to us.

Do we really stand a chance?

Unlike you to lose faith.

If we don't make a stand here

this body has had it.

I've got this. You guys head to the red bone marrow!

NK, look after yourself.

I take orders from no one.

I fight the way I want.

You really are a narcissistic jerk, ain't you?

I'm not letting you hog the glory.

I'll fight here too.

Captain!

White Blood Cell, we'll cover you.

Head to the red bone marrow!

Let's go!

Yes, sir.

White Blood Cell, go now!

Don't hang around. Go for it!

What's wrong?

It's all useless…

Our sacrifices don't make a shred of difference.

Take a look around.

Not a single red blood cell anywhere.

There'll never be enough oxygen.

This body is finished!

And I'm scared…

I just want to be at peace.

Same here.

I'm scared too! Terrified.

But at this very moment

everyone's putting up a desperate fight.

So, I will not run away.

I'll keep carrying oxygen, no matter what…

Because that's my job.

Even as a kid… she'd never whine.

When her mom died, she was the grown-up.

Look.

DAD, CHEER UP! LOVE, NIKO

I've been a pathetic dad, really.

Really pathetic…

Since I'm so useless… please,

help me keep her spirits up, yeah?

Please.

Yes.

Of course, I will.

Sir, come quickly.

Are you okay?

Blood pressure's falling.

Turn off the IV. Open up the saline drip.

Niko!

Oxygen, 5 liters via mask.

Have vasopressors ready.

Niko, can you hear me?

NK!

Niko!

Niko, don't give up!

Don't give up!

Can you hear me?

Pull yourself together, Niko!

Are you okay?

Killer T…

That was fun.

I don't mind teaming up occasionally.

Goddamnit!

You damn fool!

You lucky thing…

I was always jealous of you.

No waiting for orders… free to roam and fight at will!

Bastards!

Go.

And you…

It's up to you now…

Mr. White Blood Cell.

Leukemia cells now in the pancreatic area.

Also in the colon and small intestine.

Killer T, I need you there ASAP.

Killer T?

Please respond.

Respond!

And now they're here…

We can't do what we do without your constant supply of oxygen

I'm counting on you.

I have to go on.

I must…

It's a miracle she's holding on.

Now it's a matter of how long her body can fight.

So Niko is…

A bone marrow transplant is our only hope.

When a donor's found we'll begin radiotherapy.

Which is?

To stop the body attacking the new tissue as if it were an invader…

BONE MARROW TRANSPLANT PROCESS

…and to prevent rejection, we destroy all existing blood cells.

Over here! I've got oxygen here.

Hurry up. Get on with the delivery!

Watch out!

Miss Macrophage?

Long time, no see.

-How come? -Haven't you heard?

I wear many hats… I'm not just a teacher.

I can be a killer too.

You should get moving.

You must complete your mission.

Yes.

Let's go.

No.

I'll stay to supply her with oxygen.

I'm good now.

I'll deliver oxygen no matter what.

Because that's my job.

Oxygen here!

Mr. White Blood Cell…

Mr. White Blood Cell

Red Blood Cell.

I brought oxygen for you.

Sorry, I'm so late.

Thank you… Red Blood Cell

Not at all.

We now begin radiation therapy.

Help!

Somebody.

Help us!

What's that light?

What's going on? Why are our people dying?

I don't know…

If we lose any more, we can't protect this body.

Red Blood Cell…

At home, back in the red bone marrow,

the stem cells that created us are still at work.

Head over to those guys.

Get them oxygen.

Get them to create reinforcements.

I'm not sure I can make it.

Don't worry,

I'll always protect you.

Let's go.

We should hurry.

-We're almost there. -Okay…

I'm feeling peckish.

Give me that oxygen.

No way. You're not getting it.

Is that right? Then I'll just kill you.

Get out of here.

Mr. White Blood Cell.

Red Blood Cell, go on ahead.

-But… -Quick.

You've got a job to do.

Yes.

Big Bro.

Sorry.

I have to kill you.

I get it.

You treat me as a defective outcast too.

Then it's only fair…

if I kill you first.

How come…

everyone treats me like an outcast?

Why?

Why must I be eliminated?

I did nothing wrong.

All I did was to be born.

I wanted to be a cool white blood cell.

How's that, Big Bro?

To be killed by an ugly outcast?

Disappointing?

You must be so upset.

Tell me.

Admit that I'm stronger than you.

Dead already?

That's boring…

Thank you.

Here she is.

Niko, feeling okay?

There are practically no cells left in her bone marrow now.

It's hard to predict what happens next.

Doctor?

Is there anything I can do?

Be with her.

Help her be strong, ready for the transplant.

PAPA'S FAVORITE THINGS

BOOZE

INSTANT RAMEN

BUT THE THING HE LOVES MOST…

NIKO'S SMILING FACE

YOUR SMILE'S THE BEST THING IN THE WORLD

HE AGREES WITH ME

THEY SAY SMILING BOOSTS IMMUNITY

SO STAY STRONG!

Thank you…

Thank you…

Oh, no…

Hoping to trade oxygen for reinforcements?

Sadly, that's not possible.

Nobody's left to help you.

We were all born on the same team, right?

How come we're fighting?

We're not on the same team.

You guys chose to get rid of me.

That's why I'm changing this world.

Making it inclusive, for anyone to live free and happy.

I can't let you do that.

Ever.

That's pretty feisty.

For just a simple red blood cell.

Die, you little nobody.

Mr. White Blood Cell!

He forgot his lessons…

To get at the enemy…

I can slip through vein walls.

Why'd you do that?

I would've been a part of the team.

I wanted to work with everyone.

It's not up to me.

I can't save you.

I can't fix you.

I can't keep you alive.

Me killing you…

that's my job.

I knew it.

You are strong,

Big Bro…

Forgive me.

Someday I'll be a strong white blood cell just like you!

This body has been reduced to a critical state of devastation.

To all cells, please take any life-saving measures available.

What's going to happen?

Are you okay?

I've still got some oxygen

Here…

I don't need it…

Others do…

Give the oxygen to them…

But…

To keep this body alive…

It's up to you red blood cells.

No matter what happens…

Keep that oxygen moving.

It's a promise.

Mr. White Blood Cell…

That was you…

Red Blood Cell…

You became worthy after all.

I'm counting on you.

Red Blood Cell…

I promise.

So please, don't die.

Please!

Mr. White Blood Cell?

Mr. White Blood Cell?

Mr. White Blood Cell…

Thank you very much.

Oxygen, please…

Here, get well soon.

I've got oxygen.

Let's begin the bone marrow transplant.

Congratulations…

The stem cells are safely in place.

They're busy at work making blood.

-Right, Doc? -Correct.

Doctor, thank you.

No, it's your own strength that's brought you this far.

If your cells weren't strong enough your body wouldn't have made it this far.

If anyone, thank your own body.

Thank you.

OXYGEN

"Dear little red erythroblasts, still small and cute,

I'm a red blood cell that used to work here."

"I was clumsy and would often get lost."

"Unlike the white blood cells with their super powers."

"All I could do was transport oxygen."

"It used to make me miserable."

"But now,

I know that I was an important member of the team."

"It's not about who's superior

or who is stronger

because none of us can exist alone."

"We support and complement each other."

"That's how we protect this body of ours."

"I loved working with all those folk."

"There are about 37 trillion cells at work within the human body."

"The majority will live out their lives or be killed by external forces,

but they all pass on their work to newborn cells."

"We are all working cells."

"I hand over my work to you."

"Please keep carrying oxygen to sustain this body."

"From a red blood cell senpai who has gone before."

Everyone let's go, keep moving.

What are you doing?

Class is starting.

Coming!

ONE YEAR LATER - SPRING

Dad, hurry up. We'll be late!

Sorry. Couldn't decide on a tie.

It's not your entrance ceremony.

But it's medical school. I daren't look shabby.

I gotta look snappy.

We're really cutting it fine.

You didn't have to bother.

It's fine. You're like family now.

-Isn't that tie a bit boring? -Really? Do I change it?

-Stick with the plan, it's fine. -I'm sorry.

-Do you have a cold? -No, this is…

Whoops, you dropped something.

Thanks, Big Sis.

You're welcome.

Emergency alert!

Cedar pollen allergens detected in the ocular membranes

Cedar pollen?

Where are they? I'm going to hunt 'em down.

I'll kick their asses.

What are you looking at?

Nothing…

I just feel like I know you from somewhere.

They're close by.

White blood cell U8996, neutrophil unit.

Pollen allergen located. Now en route to exterminate.

Mr. White Blood Cell.

Will I see you again?

We work in the same body. It's sure to happen.

Then, I'll see you later.

See you.

I'm a killing machine. I'll kill every one of them.

Okay, back to work.

MEI NAGANO

RED BLOOD CELLS

TAKERU SATOH

MANA ASHIDA

KOJI YAMAMOTO

WHITE BLOOD CELLS

RIISA NAKA

WAKANA MATSUMOTO

SHOTA SOMETANI

RIHITO ITAGAKI

RYO KATO

KILLER T-CELLS

SEISHIRO KATO

SHINYA NIIRO

MAJU OZAWA

RYOKO YUUI

WATARU ICHINOSE

NK CELLS

MAIKA PUGH

DJ KOO

TAKASHI TSUKAMOTO

KYOKO FUKADA

MACROPHAGES

AINOSUKE KATAOKA

RAN OHTORI

SHINGO TSURUMI

KEN MITSUISHI

HELPER T-CELLS

FUKASE

SADAWO ABE

EXECUTIVE PRODUCER: HIROYOSHI KOIWAI

HEPATOCYTES

PRODUCERS: IKUMI TAGUCHI ATSUYUKI SHIMODA

CO-PRODUCERS: KIMIO HARA YU KUMAGAI

LINE PRODUCER: YOSHIYUKI OIKAWA

PROJECT PLANNING: KAZUYA HAMANA

SUPPORTING PRODUCER: MASAMI TAKAHASHI

STREPTOCOCCUS PNEUMONIAE

BASED ON THE MANGA CELLS AT WORK! BY AKANE SHIMIZU

CELLS AT WORK! CODE BLACK

BY SHIGEMITSU HARADA, ISSEI HATSUYOSHIYA,

AKANE SHIMIZU ORIGINALLY PUBLISHED BY KODANSHA LTD.

SCREENPLAY BY YUICHI TOKUNAGA

MUSIC BY FACE 2 FAKE

CINEMATOGRAPHY BY SOHEI TANIKAWA

STREPTOCOCCUS PYOGENES

LIGHTING BY SHUNRI RINOIE

SOUND RECORDING BY TAKASHI KANASUGI

PRODUCTION DESIGNERS: MASUMI MIURA CHIHIRO HAMADA

SET DECORATOR: KOJI SHINODA

STAPHYLOCOCCUS AUREUS

ACTION DIRECTOR: TAKAHITO OUCHI

COSTUME CONCEPTION: ISAO TSUGE

COSTUME DESIGN & PRODUCTION: TOSHIHIKO SAKURAI

WARDROBE SUPERVISOR: KOSUKE OTOMO

INFLUENZA VIRUS

HAIR AND MAKE UP BY MIHO ARAKI

EDITED BY HIROSHI MATSUO

VFX PRODUCER: HIROMASA INOUE

VFX SUPERVISOR: YU NAGASAKI

SUPERVISING SOUND EDITOR: AKIRA ITO

LEUKEMIA CELLS

SCRIPT SUPERVISOR: YOSHIE WATANABE

CASTING BY MASA SHIMOTORI

ASSISTANT DIRECTOR: KOJI HORA

BONE MARROW FLUID (HEMATOPOIETIC STEM CELLS)

NEURONS

EXTERNAL ANAL SPHINCTER

THEME SONG "50%"

PERFORMED BY: OFFICIAL HIGE DANDISM LYRICS AND MUSIC BY: SATOSHI FUJIHARA

PLATELETS

CEDAR POLLEN

SNEEZING

NO ANIMALS WERE HARMED IN THE MAKING OF THIS FILM

"CELLS AT WORK!" FILM PARTNERS WARNER BROS. PICTURES JAPAN

KINOSHITA GROUP / ANIPLEX KODANSHA / TOKYU TWINS JAPAN / SDP

PRODUCTION SERVICES PROVIDED BY TWINS JAPAN

DISTRIBUTED BY WARNER BROS. PICTURES JAPAN

PROJECT LED BY WARNER BROS. PICTURES JAPAN KINOSHITA GROUP

DIRECTED BY HIDEKI TAKEUCHI

©AKANE SHIMIZU/KODANSHA ©SHIGEMITSU HARADA ISSEI HATSUYOSHIYA, AKANE SHIMIZU/KODANSHA

©2024 "CELLS AT WORK!" FILM PARTNERS

Subtitle translation by: KENNEDY TAYLOR & AYA FUTAMI