All language subtitles for BBC.Horizon.2013.The.Truth.About.Personality.720p.HDTV.x264.AAC.MVGroup.org-eng(1)

I'm Michael Mosley.

As you can see,
I was a blissfully happy child

but, although I still try
to be cheerful,

this is now something of a mask.

I have a tendency
to be a catastrophic thinker

and I think, "Oh, it's going to be
terrible or I'm going to retire

"and I'm going to get some horrible
disease or not have any money."
Did that ever worry you?

No.

The truth is
I'm now a bit of a pessimist.

I get stressed and I constantly fret
about the future.

So, a couple of months ago,
I set out to explore

the latest science of personality,

to see if it is possible to change.

Now, in many ways, I suspect this
is going to be the hardest thing

I've ever attempted,
but the rewards are also great.

I want to become a warmer,
more open person.

I want to be happier and,
from a purely selfish point of view,

I also want to be able to sleep
better because I'm something

of a chronic insomniac
and when I get stressed,

like I am frankly at the moment,
I stop sleeping.

Is that too much to ask?

I've set myself a very ambitious
task... To change my mind.

What I've been trying is something
that requires no drugs,

no expensive therapy.

Instead, it involves
a couple of unusual techniques

and, after seven weeks,
I'm genuinely surprised

by what's happened.

That absolutely made my day,
thank you. Brilliant!

Give it up for Michael, everyone!

So, can you really change
key aspects of your personality?

And why might we want to?

This is Oxford, Ohio,
a town in the American Mid-West.

It's not a particularly
fun-looking town

but first impressions
can be deceptive.

I'm starting here because the people
in this place have revealed

the extent to which the mind
can affect the body.

They've shown that what you think
and how you think really matters.

It's a quiet - really quite
unremarkable - little town,

and yet, back in 1975,
it was the subject

of a really fascinating
social experiment,

one which has been going on now
for almost 40 years.

It started when a scientist
from the local university

came up with an ambitious plan -

to recruit all the over 50s
in the town for a study into ageing.

More than 1,000 of the locals
duly signed up.

I've come to meet some of
the members of that original group,

and they are a lively lot.

So, you guys kind of gather
every morning or...?

You sound as though
you're having a gas, I have to say.

Every morning except Sunday.
Who's the oldest person here?

He's second, I'm 90.
You're 90? He's 88.

88. You going to try
and make 100?

I don't know.
I tell you, when you get to be 90,

actually, you know,
you live from day to day.

Ken, you took part in the original
study which began in '75.

Do you remember taking part in it?

I vaguely remember
taking part in it.

I mean, did you know
how extraordinary it was

that they tried to recruit
pretty well everybody in this town

at the time, and then
they followed them

for whatever it is, 35 years now?

I don't think they've been
following me though, have they?

Secretly!

In 1975, volunteers
filled in questionnaires,

looking at things
like health, jobs, family

and attitudes towards growing older.

Do you worry about the future?

No, no, I don't worry
about the future.

I... What will come will come,
and when it comes, it comes.

But, no, no. I don't worry about it.

If you just keep cyclically thinking
bad thoughts, not good.

What do you see in people
who are negative?

What do I see in them?
I see an unhappy person.

I see a person who's more
highly stressed than others.

To be stressed all your life,
it would be...

wouldn't be a pleasant life.

Decades after the original
questionnaires were filled in,

data from the Ohio study
ended up at Yale University,

on the desk of
Associate Professor Becca Levy.

So, what sort of questions
did they ask?

One of the questions was, "How much
do you agree or disagree

with the item "as you get older,
you are less useful?""

OK, I would say
that I disagree with it

because I'm sure that,
as I'm getting older,
I'm getting more useful.

Oh, good, very good.

Another question that was asked
was, "As you get older,

"are things better, the same or worse
than you thought they would be?"

LAUGHS
OK, I think I have
no particular reason

for feeling negative
about the future and yet I do.

What are you fearful of?

I don't know, just generally
more anxious about stuff

but I don't know whether
I'm just becoming more realistic

or whether the world
really is a more frightening place

than it once was. Yes.

It turned out that how you answered
these particular questions

was a strong predictor
of how long you were likely to live.

Mental attitude was far more
important than anyone had imagined.

What we did is we tried to find
the survival patterns of everybody

who was in the original study,
so there's something called

the National Death Index
in the United States,

and we found mortality information
about all the original participants.

And when Becca went through
the death records,

she found the same thing
over and over again.

It was actually a survival advantage

on average of about
seven and a half years

for those who had
more positive beliefs about ageing.

So, something which actually
increases life expectancy

by seven and a half years
is quite a big deal, I think.

Were you excited
when you discovered it?

Yes, so it was a bigger advantage
than we had predicted

so that was really exciting
to look at.

Ready?

Get happy!

One, two, three. Fine, right?

Becca's research has been
backed by other work

looking into the power of optimism.

To put her results into context,
if we could cure cancer tomorrow,

it would half as much, three
to four years to life expectancy.

But what can you do if you're not
naturally a positive, happy soul?

I keep on thinking
that the worst is going to happen.

It doesn't happen
but, in the meanwhile,

rather than engaging in the present
and sort of being there,

chatting with my family,
I'm sometimes staring off

into outer space,
thinking about things

which will probably never occur.

I'm also still sleeping terribly
and, so, if I could do something

that would make that different,
then I would really love to do it.

Over the last few years,

I've looked at the evidence behind
the science of how our bodies work.

I've tried a lot of different
tests and procedures on myself.

Breathe in! Now I want to move on
from the body to the mind,

to examine the science
behind positive psychology.

And the first step
is to find objective ways

to measure personality.

Our personalities are a complex
interaction of character traits

that affect behaviour, emotions
and ultimately the lives we lead.

And one of THE fundamental drivers
is how optimistic

or pessimistic we are.

This is also one of the hottest
new areas of scientific research.

But how on earth
do you objectively measure it?

I am 5 ft 11, I'm 168 lbs

and my chest size is 42 inches.

Now these things
are easy to measure

but what about aspects
of personality?

Well, I've come here
to Essex University,

where they're going
to probe my brain

and apparently they can tell me

whether I am fundamentally
optimistic or pessimistic.

Professor Elaine Fox
is a neuroscientist

and one of the leading researchers
in the science of optimism.

Now, ready? All I do is put in
a small amount of gel

and then you'll feel it cold.

We know that some people's brains
tune in very much

to negative information
and others tune in

to positive information,
and what we're hoping to do,

we're measuring the electrical
activity in your brain

and we're really
just going to try and probe

and see whether your brain
naturally tunes in

to either positive stuff
or negative stuff.

I am, I must admit,
phenomenally interested

to see what you discover because...
Yes, it'll be interesting, yeah.

I would suspect that I have
a bias towards the negative.

Do you think so? Yes.

It may turn out
that I'm a rip-roaring optimist.

Well, it absolutely might,
yes, exactly.

It's funny because I have
these conversations with my wife

quite frequently because she has
a... I think, a kind of naturally

sunny disposition,
and she finds it quite frustrating.

You know, she keeps on saying,
"These things won't happen."

No, exactly. "Why do you keep
thinking about them?

"Why do you keep on talking
and planning about things,

"which the odds on them ever,
ever happening

"are just fantastically low?

"Why don't you just wait
and see what happens?"

It's a disaster,
the kids will all end up in jail.

Embarrassingly, I can't even
stop worrying

while they're setting this up.

Oh dear, there's a flashing light
there. It's not good.

It's not my bloody job, I know that.

My eye keeps on being drawn to it
and I keep on going,

"Is that important?"

Don't worry about the flashing
light.

I know, it's nothing to do with me
but I can't quite stop myself.

The first part of the test
involves measuring levels

of electrical activity on the two
sides of my brain while I'm resting.

Surprisingly enough,
studies have shown

that people who are prone
to high levels of pessimism,

neuroticism and anxiety tend to have
greater activity

on the right side of their
frontal cortex than the left.

This is known as cerebral asymmetry.

We know it happens,
we don't know why.

Now for something more active.

Elaine's asked me
to press a button

when I see dots flashing up
behind faces on the screen.

At the moment, I'm just in a kind
of a completely zoned-out territory.

I have no idea.

That was a cock-up, yeah.

I didn't realise
while I was doing it

that the whole point is to test
unconscious biases.

They wanted to see
if my response time was influenced

by whether the dots appeared
behind angry or behind happy faces.

Did that kind of go
as you'd planned?

Yes, it did. There's the data.

Ay-ay-ay!

God, this is not a good look, is it?

KNOCKS
Hello, there! Hi, Michael.

A couple of hours later,
and my results are ready.

The computer measured the speed
that you pressed the button

and sometimes there was
an angry face on the left hand side,

say, sometimes a happy face
on the right hand side,

so you can see that's how quickly
you responded

when the target
appeared near the angry faces.

It's extraordinary. My reaction
times are much faster...

Much faster, as you see.
..with the angry faces.

Exactly, so when the little probes
appeared where the angry faces were,

you were actually
much, much faster, so...

That is, OK, that is extraordinary.

I had absolutely no idea
that was going on at all.

Exactly, it's a little probe
into your mind showing us

your brain is just slightly faster
because you were already there.

Your attention has gone
to the angry face immediately,

so when you react,
because you're already there,

you're a little bit faster.

But Elaine has found something else
which is a bit more unsettling.

The first part of the test, where
they measured my brain activity

at rest, revealed I have nearly
three times more activity

in the right frontal areas
than the left.

This suggests a brain that is
even more tuned to the dark side

than I thought.

I would have been surprised
if your machine had decided

that I was a raging optimist,
because that isn't true.

But I'm also not clinically
depressed either.

That's what it shows.

I incurred a bit on the negative
side, but not extraordinarily.

I think that's exactly... It's on
the negative side of the spectrum.

I'm now wondering if Elaine
is simply being diplomatic,

and if my results are rather worse
than she's suggesting,

or is that just paranoia?

So, that test has shown what I guess
I've always believed,

that I have a fundamentally
negative filter and that makes me

prone to pessimism, anxiety
and also sometimes neuroticism.

It colours my relationships and also
affects how I react to the world.

# Sometimes I go out by myself... #

A brain that is hyper-aware
of things that can go wrong leads

to increased stress and anxiety, and
it's more than just a state of mind.

It's powerfully connected
to how your body responds.

I've come to this karaoke bar
to sing - badly -

in front of 100 strangers.

I'm here to demonstrate
what happens to your body

when you allow negative thoughts
to dominate your mind.

# ... over, Valerie. #

# So now you're back
from Outer Space

# I just walked in here
to find you here

# With that sad look
upon your face... #

My body is really screaming at me,

this is a really, really bad idea
because my pulse is running

at around 120, my mouth is dry
and I've got a faint tremor.

Areas of my brain that deal
with fear and threat have kicked in.

These evolved to ensure survival

but today it's not a sabre-toothed
tiger that's terrifying me,

it's just a little sing-along.

I mean, it's sort of odd

because you'd imagine somebody
who makes a living out of

appearing in front of a camera would
feel quite comfortable, but I don't,

I don't feel remotely comfortable
about doing anything like this

and I can see the whites
of everyone's eyes

and that fills me with horror.

Will you please welcome
the next singer?

Mr Michael Mosley!

# First I was afraid,
I was petrified

# Kept thinking I could never live
without you by my side... #

The first bit of the song is OK
because I just have to shout

but when the music kicks in,
I'm stuffed.

Before I came on, I was thinking,
what happens if I freeze?

And that thought
became self-fulfilling.

I've totally shut down.

Now this is obviously
a highly unusual situation

but it certainly demonstrates
the power of negative thoughts

to influence human physiology.

After the pleasures of karaoke,

I'm in Boston, Massachusetts,
where engineers have invented

a discreet way of measuring
that most elusive of things -

our emotions.

It's a device created
by Professor Ros Picard,

who runs the media lab here,

and it's something you can wear
day and night.

So, Ros, I've got these wrist bands.

What exactly are they doing?

You need to think about this sort of,
as like a new kind of

wearable microscope that lets you
look inside your body

and see some things that previously
you couldn't, couldn't see.

How interesting! So, essentially,
you're using these

to read emotions that people

cannot necessarily express or don't
even know they're experiencing?

That's right, and sometimes
they're full of surprises.

Oh, you're tantalising me.
You're doing very well.

OK, are you wearing a pair
or is that just a big, snazzy watch?

Yeah, this is just a prototype of
a future version that's coming out.

OK, great.

The wrist bands can monitor
someone's emotional state

by detecting minute changes
in the electrical conductivity

and temperature of the skin.

These are driven by the so-called
autonomic nervous system.

And I'm being monitored
even while we talk.

Why not just rely on people
filling in questionnaires?

Why do you need technology?

Oh, goodness! People just will say
the darndest things

on questionnaires, right?

They'll think that they're happy,
"Of course I'm happy," you know,

and, finally, you know,
20 samples later,

they realise they're miserable,
all right?

We find that the body
often tells you

there's a change in your state
well before your mind recognises

that change, so even if you're trying
really hard to be truthful

on a questionnaire, usually
your awareness of what's going on

lags quite a bit behind.

OK, you've been wearing
these wrist bands the whole time

we've been interacting,
and now I'll take them off

and we're going to take a look
at your data.

OK, and you can do it that fast?

Oh, yes, it's very quick.

It's not often you get
to see a chat going on

and also see at the same time
what's going on inside you.

The readings are higher
when I'm excited or anxious,

and lower when I'm calm.

It's what Ros calls
my arousal level.

All right,
what we have here is four signals.

The red is your right side,
the blue is your left side.

This is my left side
and my right side.

So, first of all, we're seeing
that your baseline arousal

is higher than mine
during this social interaction.

So, the wrist bands show
I'm more aroused than Ros

but am I stressed or just excited?

As with the brain test
I did earlier,

the thing Ros is interested in is,
which side of my body

is showing more activity?

There's clearly higher response
on my right wrist than my left,

and research suggests this
can be linked to my amygdala,

a part of the brain which evolved
to deal with fear and threat.

Now, most arousing experiences
activate both of them

but certain kinds of experiences,
like social phobia,

or threat-type situations, we would
expect for a right handed person,

the right one to be activated more.

How interesting! So, that is
absolutely compatible with somebody

who feels mildly socially phobic
and is an uncomfortable situation?

That is what we would expect.

Wow! And that is quite tiring,

I imagine, looking at that to
sustain that sort of level of peak?

It's work. Being around people
can be hard work.

Thank you, it's been absolutely...
It has been genuinely fascinating.
Thank you.

# I'd rather go on the road

# Nah, nah, nah, nah, nah, nah

# I'd rather go on the road

# Nah, nah, nah, nah, nah, nah

# I'd rather go on the road

# Nah, nah, nah, nah, nah, nah... #

Ros's emotional microscope
has certainly exposed

the sort of feelings
that most of us try to hide.

And I was really surprised because
I thought I would be the cool one

and she would be the nervous one,

but actually it turned out to be
the absolute other way round.

I didn't actually feel nervous

but clearly my system
was firing on all cylinders.

And these levels of heightened
anxious arousal are something

I want to change, not least
because it has probably contributed

to making me a chronic insomniac
for the past 20 years.

OK, oh, dear.

I've had a spectacularly
bad run of nights recently.

Up at about sort of 4 o'clock
last night.

You can probably see the bags
under the eyes.

And, um, let's see
how tonight goes.

I hope it's better than last night.

Good night!

Yeah, it's 4:30am
and I'm wide awake.

Lots of thoughts racing
through my head

and so I thought
I'd get up and sit around a bit.

I'm going to try two different
techniques, which have been shown

to reduce negativity and stress.

To learn more
about the first technique,

I've come back to Essex University.

Professor Fox's brain test
measured my levels of pessimism

but being a very positive person
herself, she's convinced that

not only can she help me,
but we'll see changes in my brain.

She introduces me to cognitive bias
modification - CBM.

Basically, it's very simple.

If you just press 'start' there,
you'll see an array of faces.

Now, your task is simply
to click on the happy face.

OK, OK, happy. Yeah, and then
just keep going, basically.

Blimey, it's quite difficult
to find them, isn't it?

Yeah, so just find a happy face.

There have been many studies of CBM
involving several thousand people.

The idea is you reduce
your unconscious negative bias

by training yourself
to seek out the positive.

OK, whoo!

No, he's not down there.

Let's go across down there.

I simply have to spot
the smiley faces.

How hard can that be?

You think when you look at it,
it's going to be dead easy but...

That's right,
it's more difficult than you imagine

and it shows us how distracting
the negative faces can be.

I do actually like the smiley faces,
you know,

and yet I'm obviously drawn
to the dark side.

Yes.

Your brain has obviously
got into a habit of looking

on the negative side of things,
so what we're trying to do really

with this cognitive bias modification
is to really try to break that habit.

The majority of people
who have been studied

showed a significant reduction
in their negative bias.

I have to say if it works,
then the beauty of this is

you can absolutely see you can just
do it on your computer at home.

Absolutely, and that's the idea.

What we're hoping eventually
is that people can almost use this

as a little top-up. It's like,
you know, if you feel

you're in a particular negative mood,
you can do ten minutes of this

and you know it can kind of
just boost that bias.

OK, I remain sceptical
but I will certainly,

I will certainly give it a go.

Elaine set it up so I can do this
at home three times a week.

Where is it? Sometimes it's really,
really annoying,

I just can't find them. Aha! OK.

Yeah, I'm on a roll.

I'm just kind of letting
my unconscious do the work

and, ideally, I just kind of
don't even think about it.

I have absolutely no idea
whether this is helping

but I'm not convinced
I'm actually getting any faster.

Where are you, where are you? Ah!

It looks incredibly simple.

But there is evidence it will combat
anxiety, though not depression.

# Suddenly, I'm hit

# It's the starkness of the dawn

# And my friends are gone

# And my friends won't come

# So, show me where you fit... #

One of the things that undoubtedly
adds to my feelings of anxiety

is my tendency
towards self-absorption.

I'm rarely enjoying the moment,
being in the present.

Instead, I'm off worrying about the
past and stressing about the future.

This is a very common problem and
it's making a lot of us miserable.

So, I'm off to find out more about
a second technique that may help.

I feel like I've got caught
in the sort of negative rut

of ruminating, and I've spent
a lot of time now visiting labs,

learning about the science
of the brain but, oddly enough,

where I'm going now in search of
solutions is to visit a former monk.

Followers of different religions
have practised meditation

for thousands of years.

There are, of course, many different
ways of doing meditation,

including secular versions.

Tonight's teacher, Andy Puddicombe,
was once a Buddhist monk.

He now teaches
a modern take on an old idea.

Now, take a moment to think
who here struggles with sleep.

Quite a few of you, right?

When you've gone to bed
and you really need to sleep, OK,

what's the temptation?

To try a little bit harder, right?

And then you start
to get a little bit tense

because you're not falling asleep,
so you try even harder,

and then you realise that you're
trying too hard to get to sleep

so you try not to try to get
to sleep, so there's a time

and a place for stepping back
and saying, you know what?

It's not about effort.
Meditation's the same.

You can't force
a state of relaxation.

This is a treat,
it's not a chore, OK?

This is YOU taking ten minutes
out of your day to do nothing,

nothing at all.

It's such a rare opportunity.

Ten minutes out of my day
is not a huge commitment.

So, I'm certainly interested enough
to want to find out more.

I'm a chronic insomniac,
I wake at 3 in the morning

and I have loads of thoughts
racing through my head.

I have spent 15 years
looking at sleep.

I have made, you know, at least
three programmes on sleep.

I know pretty much everything
there is to know about sleep

but it doesn't make any difference.

The science that's coming out is
showing that actually even ten,

15, 20 minutes a day, that's enough
to make not only

a psychological difference but
a physiological difference as well.

Over the past 20 years,

there have been lots of studies
of varying quality into the benefits

of meditation, which have produced
rather conflicting results.

But, recently, there have been
more rigorous studies,

involving brain scanners
and these have allowed scientists

to see what's happening
inside the meditating brain.

There is evidence of changes in
the brains of long-term meditators.

Even novices doing it for just
eight weeks showed some differences.

In one study, there was increased
grey matter in areas

involved in emotional regulation,

and increased activity
in the left pre-frontal cortex

that deals with positive emotions.

It's early days, but the evidence
is certainly mounting

that regular meditation
can lead to physiological changes.

If it is THAT easy,
why haven't more people done it?

Yeah. And this is the thing.
I wouldn't say it's easy.

I'd say the idea is easy, OK?

The application, like anything,
it's like losing weight,

going to the gym.

We still need to actually do it

and we have to do it on
a daily basis to see the results.

There is nobody I know who wouldn't
benefit from being more present,

having a greater sense of calm,
a greater sense of clarity,

and, ultimately, a greater sense
of contentment in life.

Is six to eight weeks enough?
It is enough, yeah.

You could actually see changes
possibly in my brain pattern

in six to eight weeks? Absolutely.

So, it's time
to give it a go myself.

I'm going to try and calm
my brain down by simply focusing

on my breathing and being less
distracted by my negative thoughts.

Oh! And I have
to try and stay awake.

I'd like you to begin
by just noticing

the weight of the body on the chair

and just starting
at the top of the head,

I'd like you to just gently scan
down through the body,

just noticing which parts
of the body feel relaxed

and which parts feel perhaps
a little tense or tight in some way.

Then, if thoughts arise,
that's perfectly normal.

Allow thoughts to come and go.

As soon as you realise
the mind's being distracted,

just gently bring the attention
back again.

And, in your own time,
when you're ready...

You can just gently
open the eyes again.

OK, so how many of you feel better

than you did ten minutes ago?

OK. It's amazing.

There's a tangible thing
happening here.

We train the mind,
we will be more present,

our mind will wander less,
we'll get less stressed

and we're less likely to go down
those routes, those habitual paths

of stress, of anxiety, of sadness,
whatever your thing may be.

That was good actually,
because I wondered

whether I would be able
to get into any sort of a state,

and I feel a little bit heavy-limbed

but I also feel perhaps a little bit

more relaxed than when I went in,

and I veer wildly between optimism

and pessimism, so that part of me
thinks that I'm going to manage

to do this and part of me thinks
it's simply going to be too hard.

But, at the moment,
the optimist is winning out.

To give this a decent chance
of working, I have to commit

to doing it every day,
building up from ten to 20 minutes.

And I'm going to combine it
with cognitive bias modification.

In seven weeks,
I'll get my brain re-tested

to see if I've really managed
to change my mind.

OK.

But, while I do that, there's a
deeper question I'm grappling with.

Where does a tendency towards
being optimistic or pessimistic,

calm or anxious, come from?

I was a happy child, carefree even.

So, yeah, there I am.

I'm not... Don't know
if I've ever seen this.

It doesn't ring a bell.

OK, so this is definitely
the Philippines because I was there

when I was about,
between the age of two and five.

And there's my mother, right.

She looks ludicrously young,
my mother.

I asked her about how she remembered
ME from childhood

and she said that
I was uncomplicated,

that I got on with things, I seemed
to be open and friendly and, looking

at this footage, it certainly
looks like I had a happy childhood.

Just on a swing,
rocking to and fro.

There are lots of pictures of us
here. There aren't really
any pictures of my father here.

There are pictures of my mother,
but my father was always working.

He was never really around
in our childhood - very little.

In terms of personality,
my father was a jovial extrovert,

while my mother was a bit more
uncertain and reserved.

Like everyone, I came to be who I am
today through some combination

of the genes I inherited
and the events I've experienced

throughout my life.

Oh, dear!

I feel I am so utterly different
to what I must have been like

at the age of three or so.

I look so cheerful.

There are a lot
of rather big theories

about how personality comes about

but I'm in search
of cutting edge science.

I'm starting at St Thomas's Hospital
in London

where, for many years,
a research unit has been analysing

and probing a very special
group of people - twins.

Twins are one of nature's wonders.

Identical twins share the same DNA.

They often dress the same,

look the same,

laugh at the same jokes.

And so, hundreds of twins have been
scrutinised to understand

the subtle interplay
of nature and nurture.

I just think it's absolutely
wonderful, I must admit,

being surrounded by identical twins.

Professor Tim Spector
has studied twins for over 20 years.

The first and most obvious question
I want to ask

is, when it comes
to your personality,

how much is inherited
directly from your parents?

Twin studies have told us

that personality has a heritable
component, and they tell us

that generally
40 to 50% of personality,

of differences between us
in personality,

are due to genetic factors
and the rest, either random,

or due to environment.

Tim spent the early years
of his career investigating

what made identical twins
uncannily similar.

Then he changed
the focus of his research,

began to wonder why identical twins
are not always identical.

Three years ago,
I just changed my mind.

Because twins
don't get the same disease,

don't die of the same things,
it can't just be genes alone

and let's look at the differences
between identical twins

and that could probably tell us
MORE than why they're similar.

That's great about being a scientist
rather than a politician -
changing your mind.

You can change your mind and no-one
stops voting for you, that's right.

Tim wanted to find out how people
who are born with the same DNA

can end up very different.

I've come to meet a particularly
unusual pair of identical twins,

Debbie and Trudi.

Oh!
LAUGHS

Oh, dear! I've obviously got
dirty fingers there.

I'm wiping them off.
Oh, what's she found?

Like all identical twins, Debbie and
Trudi were born with the same DNA.

Have you noticed that your trousers
are a different colour?

You've got brown trousers on.

No, you're the one in the yellow
coat with the brown trousers.

I've got blue trousers on
with a white coat. That's you!

No. Oh, yes, that's me.
Yes, that's definitely you, look.

They shared the same environment
for the first 20 years

of their lives, went to the same
schools, had the same friends.

THEY LAUGH
I think that's brilliant.

You just couldn't coordinate,
could you, really? No, not really.

We were cute, weren't we?

You are cute, honestly.

THEY LAUGH

You might expect them, like most
other sets of identical twins,

to have similar personalities.

You can see we're just, you know,
happy. Happy, happy, happy.

You look jolly children. We were.

And that's possibly because we never
felt that we were on our own.

We only ever needed each other.

Well, let's put it this way,
anybody throughout our lives who

got in the way of that
relationship didn't last.

Scary!

The twins are still extremely close
and spookily similar in many

respects, but these days, there is
a critical difference.

Unlike her twin, Debbie has
developed clinical depression.

If I had met you at 16,
would you have been able to predict

which of you would have
become depressed? No. No.

Would you have said either of you
would become depressed? No. No.

No.

Today, Debbie and Trudi have come to
St Thomas's Hospital for tests.

They're part of a group of what is
known as discordant twins

that Tim is studying.

How can twins who share the same DNA

and the same life experiences
end up being so different?

Tim thought it must be
because something had happened

to their DNA,
so he began looking for differences.

Because, surprising though it may
seem, our genes aren't fixed.

They can change.

As we go through life, all our genes
are changing constantly.

As we age, some of them
are being switched on, some of them

are being switched off.
And we think that these are actually

reflecting things like our
environment and the lives we've led.

They're like a marker
of our lifelines in a way.

This process is known as
epigenetics, and I think it is one

of the most exciting
developments in modern medicine.

Life events can change
the activity of our genes,

so it seems at some point
in Debbie's adult life, changes

to genes in her brain made her more
vulnerable to bouts of depression.

So with somebody like Debbie
and with Trudi,

did you actually find
differences in their DNA?

We did,
and when we looked at a larger

group of 30 of our twins, where
one was depressed and one wasn't,

we saw certain genes
coming up time and time again.

We identified about five or six that
were clearly different,

particularly in areas like the
hippocampus, which we know are very

important in anxiety and depression,
where a lot of the emotions are.

I have to say,
I find it mind-boggling.

Well, that's the exciting
bit of science,

and the fact that we're only
able to do this in the last

couple of years because of the
amazing advance in technology.

We all know that stressful,
emotional events, like a death or

a separation, can trigger
depression, but what scientists now

believe is they can also change
the behaviour of our genes.

This raises the enticing
possibility that

if your genes can be switched one
way, then maybe, just maybe,

they can also be
switched back the other way.

Well, we used to say we can't
change our genes, but we now know

there are these many mechanisms that
can switch them on and off,

and suddenly we're regaining control,
if you like, of our genes.

I like the idea of regaining
control,

and that encourages me to keep
going at mindfulness and CBM.

It's quite charming, really,
because you just kind of

have grown to know them a little
bit, these faces.

My seven weeks are almost up,

and I've got one more
neuroscientist to meet.

'An inspiring guy who's been working
on the puzzle of genes and
personality for a decade.

'Professor Michael Meaney has been
able to do pioneering work

'thanks to a unique collection.'

Wow! This is quite a lot of brains.

It's impressive, isn't it?
It is, yeah.

This is the Quebec Brain Bank.

It takes an enormous amount
of organisation,

and it was something that started
with just an idea, right,
of could we collect brains?

Each of these 3,000 brains
once contained a unique personality,

a unique set of memories
and experiences, and each

is accompanied by a biographical
record about the individual.

This is the great virtue
of this particular bank,

is they use a process referred
to as forensic phenotyping, so what

they're doing in fact is to
go back and interview family members

and to find out as much detail
as possible about the developmental

history of the individuals as well
as their level of pathology.

Michael set out to identify
the precise areas in the brain

where anxiety is controlled,
but with billions of cells

in an average brain, it would
have been an impossible task.

So he turned to a group of small,
furry mothers to help - rats.

He started by looking
at the long-term effect on baby rats

of good or bad maternal care.

What does maternal love or affection
look like in a rat, then?

It's essentially licking, we think.
It's tactile stimulation.

It's what you do when you hold an
infant, when you caress an infant.

It's physical contact between
the mother and the offspring.

What surprised us is the variation,
that there are really some

mothers who lick two, three times
as frequently as do other mothers.

So there you see.
Ah, OK, little baby rats.

Little baby rats. And what the
mother's doing in the course of her
nursing of the offspring

is to lick individual pups,
which you can see right there.

And it turns out that the pups
that are reared by mothers who lick

more frequently grow up to develop
more modest responses to stress.

Michael found that the amount a baby
rat was licked influenced

the activity of the gene that
protects the rat

later in life against stress
and anxiety.

This was a clear epigenetic effect

and was similar to what
happened to the twins.

Something in the baby rat's brain
had been modified by its life

experience, but did this change also
affect the next generation?

Have you reared them
through generations to see

if the pups who were
the offspring of low-licking mothers

themselves become
low-licking mothers?

Yes, the great female rat
nightmare comes true.

They become their mothers.

And so really what you have is
a situation in which you can

transmit these differences
across multiple generations. Right.

I must admit, I'd never thought
about neurotic, anxious rats before.

You can start now!
MICHAEL LAUGHS

And what's striking is
the changes in the rats' genes

brought on by maternal care were
detectable in their brains.

What you're looking at here
are sections of a rat brain,

and in particular what we're
interested in is the hippocampus.

And the hippocampus is associated
with stress, emotion and memory?

Exactly, all three.

So we now have to find the molecules
within the hippocampus that

control the stress response,
and we find a particular molecule

known as the
glucocorticoid receptor.

It turns out that the number of
these crucial receptors they found

in a rat's brain could be predicted
by their mother's behaviour.

Better mothering led to more
receptors.

And what you find then is that the
mothers who licked their offspring

more, produce offspring who then
show more modest response to stress.

How very satisfying. That must
have been rather exciting...
It was, it was.

I find this work stunning and ever
so slightly disturbing.

A clear link between the amount
of maternal affection a baby rat

receives with changes in its genes
and in the anatomy of its brain.

But is this true of humans?

This is where Michael's collection
of human brains proved invaluable.

He studied the brains of people
who'd suffered from extreme anxiety,

and he found the same changes
as in the rats.

By looking at their childhood
records, he could also tell

if they had reported receiving good
or bad maternal care.

Maternal care is actually
a major influence,

and perhaps the pre-eminent
influence in defining how we respond

to stress. So it's not only true for
a rat, it's true of our own species.

So if I respond badly to
stress events,

and we all have stress
events in our lives, it could be

because I have low levels
of glucocorticoid in my brain?

It could very well be.

So the reason I'm a terrible
insomniac could be,

I could blame it on my mother not
licking me enough?

You can try.
MICHAEL LAUGHS

When you put the research on twins
together with Michael's work,

it adds up to a really powerful new
way of being able to study

the forces that
shape our personality.

Personality is not just
something we are born with,

but something that is subtly shaped
and modified throughout our lives.

And that thought that we are quite
flexible makes me feel cheerful.

Maybe the meditation and the CBM
are starting to work after all.

VOICE ON TAPE: 'Meditation benefits
those around you as well.'

My wife, Clare, certainly seems to
think something's happened.

Given that you've been under quite
a lot of stress recently,

actually, you seem to have been
sleeping better.

And you've certainly not...

You've dealt with the stress,
I think, amazingly calmly.

Whether that's meditation,
I don't know, but I think...

..I think it's helped.
I do think it's helped.

What do you think?

SHE LAUGHS
Hiding!

It's results day and I'm feeling
uncharacteristically optimistic.

It's been a really
stressful few weeks

and I have been working a great
deal, but I've been sleeping better

than I have for ten years
and I'm feeling quite good.

But will the machines agree?

'Although I feel better,
I also want some concrete proof.

'Have I actually changed my brain?'

Hello, Michael, welcome back to the
lab. How are you?

I'm going to stay in this
position, I think.

Yes, we're gunging you up again.

So as well as the smiley faces,

I've also been doing
mindfulness meditation.

I have to say, that is more
challenging, just sitting there,

not doing anything, sort of just
listening to your breath. Yes.

Certainly, when it came to the
kind of 20 minutes, I would

find myself sneaking a look at my
watch after about 16 minutes.

Just doing it was so not what
I normally spend my life doing.

OK, do you feel any more positive?

I think I do, actually. I'm
feeling... I feel more cheerful.

First, the team measure my cerebral
asymmetry while I'm resting.

Seven weeks ago, I had nearly
three times more activity

in my right frontal cortex
than my left one,

which was a striking indicator
of pessimism.

Next, I'm repeating the test
with the faces, to see

if my reaction times have changed.

Seven weeks ago
I was much quicker to hit the button

when an angry face appeared.

Will that still be true?

I'm vaguely conscious
there are faces appearing, but...

..couldn't tell you.

It's actually completely impossible
to tell how you're doing on this.

So, have seven weeks of mental
training made any measurable
difference to my brain?

Great, moment of truth, then.
Yes, exactly, yes.

OK, well, we've got the results here,
and as you can see here, the blue...

'First, I get the results for my
reaction times to the face test.'

Seven weeks ago, my reactions to the
happy faces were much slower

than the angry ones,
but this has now reversed.

I'm much quicker to react
to happy faces.

This suggests I may be noticing the
positive more in my everyday life.

And now you can see this has
flipped completely.

You're now faster when there
was a happy face, compared to...
So it really has made a difference.

I'm amazed. I'm just impressed that
it comes up with the results.

Yes, and again... You're measuring
things which are unbelievably subtle
and speedy, aren't they?

Well, they really are, and
if we look at the reaction times,

it's milliseconds, so we're not
talking about huge differences.

It's not seconds, it's milliseconds.
Yeah, thousands of.

So you consciously wouldn't
really be aware of that,

but actually, in brain time,
that's actually quite meaningful.

'Mine is just one result
but it fits in with studies which

'suggest that this technique can
reduce negative bias and anxiety.

'And the changes in my cerebral
asymmetry are also fascinating.'

The activity in my right frontal
cortex has significantly reduced,

which suggests a shift towards
a positive mental state.

And my suspicion is, even though
we can't really separate them,

my suspicion would be that this is
more driven by the mindfulness

meditation, because there's
a lot of evidence showing that with

these measures, mindfulness is very
powerful and very effective.

So, initially, you were showing a
very typical pattern of pessimist.

Now you're showing a much more
typical pattern of an optimist,

so it looks like your brain has
shifted in a slightly more
optimistic direction.

So you really can change your mind?
Yes, you can, and it's not easy.

'I am pleased, but the real
challenge is to keep on doing it.'

Fantastic. That's absolutely made
my day. Thank you, brilliant.

I shall go off and celebrate now.

I'm absolutely delighted
and also I'm frankly astonished

that in just seven weeks you can
see that much change.

I set out to see
if it's possible to change my mind,

and I think I may well have done it.

I am absolutely thrilled.

MUSIC: "Bad Moon Rising"
by Creedence Clearwater Revival

I discovered that life events can
lead to deep, long-lasting

and measurable
changes in our brains.

# I see the bad moon a-rising... #

But I've also discovered
that our personalities are more

malleable than many of us think.

Negative thoughts can
dominate your life.

But I certainly have found something
to be cheerful about again.

# I see the bad moon a-rising

# I see trouble on the way

# I see earthquakes and lightnin'

# I see bad times today

# But don't go around tonight

# Well, it's bound to take your life

# There's a bad moon on the rise. #

Subtitles by Red Bee Media Ltd