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1
00:00:01,377 --> 00:00:04,294
From the plagues of egypt
2
00:00:04,380 --> 00:00:06,296
to the black death,
3
00:00:06,382 --> 00:00:08,382
smallpox,
4
00:00:08,467 --> 00:00:10,134
cholera,
5
00:00:10,219 --> 00:00:12,011
and the spanish flu,
6
00:00:12,054 --> 00:00:15,889
humans have repeatedly
faced contagious diseases
7
00:00:15,975 --> 00:00:20,185
that have the power to
change the course of history.
8
00:00:20,896 --> 00:00:24,064
We like to think that
modern medicine
9
00:00:24,150 --> 00:00:27,860
can protect us against almost everything,
but...
10
00:00:27,903 --> 00:00:29,653
Is that really true?
11
00:00:29,697 --> 00:00:31,780
Or are we destined
to face a future
12
00:00:31,866 --> 00:00:36,326
of ever more potent illnesses
13
00:00:36,412 --> 00:00:40,247
that attack without warning
14
00:00:40,332 --> 00:00:43,667
and can bring
civilization to its knees?
15
00:00:43,753 --> 00:00:45,586
Well...
16
00:00:46,839 --> 00:00:49,298
...That is what
we'll try and find out.
17
00:01:06,567 --> 00:01:08,567
News reports surface that a new,
18
00:01:08,611 --> 00:01:13,113
highly contagious disease
first discovered in wuhan, china,
19
00:01:13,199 --> 00:01:16,116
is spreading like wildfire.
20
00:01:16,202 --> 00:01:18,535
In a matter of weeks,
the lethal virus...
21
00:01:18,621 --> 00:01:22,039
Known as "coronavirus"
or "covid-19"...
22
00:01:22,124 --> 00:01:23,707
Sweeps the globe.
23
00:01:23,793 --> 00:01:25,334
On March 11,
24
00:01:25,419 --> 00:01:27,219
as the number of
infections and deaths
25
00:01:27,296 --> 00:01:29,379
continue to climb,
26
00:01:29,465 --> 00:01:32,216
the world health
organization declares
27
00:01:32,259 --> 00:01:36,178
that the outbreak has
become a worldwide pandemic.
28
00:01:37,264 --> 00:01:39,515
What separates, clinically,
29
00:01:39,600 --> 00:01:43,769
coronavirus from other
common viruses such as influenza
30
00:01:43,813 --> 00:01:46,772
is that it knows
how to hide itself.
31
00:01:47,691 --> 00:01:53,070
It has what we call a period
where you could be asymptomatic.
32
00:01:53,155 --> 00:01:55,072
That means without symptoms.
33
00:01:55,157 --> 00:01:58,659
That's a chance to pass
that virus to other people,
34
00:01:58,744 --> 00:02:01,954
keeping the disease
going on and spreading.
35
00:02:02,039 --> 00:02:04,498
Most of the time,
when you wait for these symptoms,
36
00:02:04,583 --> 00:02:06,208
you've already missed it.
37
00:02:07,128 --> 00:02:08,980
In the wake
of the harrowing effects
38
00:02:09,004 --> 00:02:10,879
of the coronavirus outbreak,
39
00:02:10,965 --> 00:02:13,173
scientists have been
compelled to reexamine
40
00:02:13,259 --> 00:02:17,219
the nature of
viruses themselves.
41
00:02:19,348 --> 00:02:21,515
Viruses are very mysterious,
42
00:02:21,600 --> 00:02:23,392
because you can't see them.
43
00:02:23,477 --> 00:02:25,894
You need a very
powerful microscope
44
00:02:25,980 --> 00:02:27,187
to be able to see them.
45
00:02:27,273 --> 00:02:30,232
And we didn't even know
that they were around
46
00:02:30,317 --> 00:02:33,652
until relatively recently.
47
00:02:34,864 --> 00:02:37,884
A virus is
essentially a bit of nucleic acid,
48
00:02:37,908 --> 00:02:39,533
either dna or rna,
49
00:02:39,618 --> 00:02:42,452
encapsulated in some
sort of coating. Right?
50
00:02:42,538 --> 00:02:46,248
So it needs to... it needs
to get into another organism
51
00:02:46,333 --> 00:02:50,460
and then essentially hijack that
organism's cellular machinery
52
00:02:50,504 --> 00:02:53,338
to make more copies of itself.
53
00:02:54,633 --> 00:02:56,027
It needs to
54
00:02:56,051 --> 00:02:58,844
actually take over
another living cell.
55
00:02:58,888 --> 00:03:01,305
And whether that's the
living cell of a human,
56
00:03:01,390 --> 00:03:02,681
animal,
57
00:03:02,725 --> 00:03:05,893
plant or even a bacteria,
58
00:03:05,978 --> 00:03:07,477
it needs that.
59
00:03:07,563 --> 00:03:09,980
It's making more
and more viruses
60
00:03:10,065 --> 00:03:11,940
till that cell is not
needed anymore.
61
00:03:13,444 --> 00:03:16,153
A virus relies on either
62
00:03:16,238 --> 00:03:19,656
direct transmission through
sneezing or coughing
63
00:03:19,742 --> 00:03:21,428
or touching, um,
a viral particle
64
00:03:21,452 --> 00:03:22,951
from a person who's expelled it.
65
00:03:24,747 --> 00:03:28,290
Or they rely on a mosquito
or some other organism
66
00:03:28,375 --> 00:03:30,295
to be transmitted
between people.
67
00:03:31,253 --> 00:03:33,086
And so the density of people
68
00:03:33,172 --> 00:03:36,548
will facilitate quicker
spread of viruses,
69
00:03:36,634 --> 00:03:38,884
especially if it's, um,
relatively contagious
70
00:03:38,969 --> 00:03:42,095
and-and easy to-to transfer
from one person to another.
71
00:03:42,932 --> 00:03:44,681
According to experts,
72
00:03:44,767 --> 00:03:46,516
the origins of many viruses
73
00:03:46,602 --> 00:03:49,561
remain shrouded in mystery.
74
00:03:49,605 --> 00:03:51,208
It's so difficult
75
00:03:51,232 --> 00:03:53,815
to determine the origin
of viruses because,
76
00:03:53,901 --> 00:03:56,151
when you want
to study that virus,
77
00:03:56,237 --> 00:04:01,031
you have to separate what is
the natural history of that cell.
78
00:04:01,075 --> 00:04:02,908
So one of the important things
79
00:04:02,993 --> 00:04:06,995
that epidemiologists
are looking at right now is,
80
00:04:07,081 --> 00:04:09,248
what did we learn from the past?
81
00:04:09,333 --> 00:04:10,874
What should we be looking at?
82
00:04:10,960 --> 00:04:12,584
Where should we be looking?
83
00:04:14,630 --> 00:04:18,382
Some of the earliest
records of plagues
84
00:04:18,467 --> 00:04:21,343
are found in ancient india,
85
00:04:21,428 --> 00:04:23,929
china, the middle east,
86
00:04:24,014 --> 00:04:26,890
and they talk about
plagues occurring
87
00:04:26,976 --> 00:04:29,309
before the very
first civilization,
88
00:04:29,395 --> 00:04:32,104
around 3200 bc.
89
00:04:32,189 --> 00:04:34,231
Throughout human history,
90
00:04:34,275 --> 00:04:36,566
there have been accounts
of devastating afflictions
91
00:04:36,610 --> 00:04:41,113
that defied understanding
at the time they happened.
92
00:04:41,156 --> 00:04:44,741
But perhaps a closer
examination of these plagues
93
00:04:44,827 --> 00:04:48,954
will provide some lessons
about infectious diseases
94
00:04:48,998 --> 00:04:51,206
and how they begin.
95
00:04:59,675 --> 00:05:03,260
Emperor justinian sits
atop a powerful throne.
96
00:05:03,345 --> 00:05:06,805
But lurking in the
shadows is a hidden enemy
97
00:05:06,890 --> 00:05:09,933
about to consume his kingdom.
98
00:05:11,103 --> 00:05:12,561
A plague
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00:05:12,646 --> 00:05:14,896
started by a bacteria
100
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comes out of the east
101
00:05:16,734 --> 00:05:19,109
and infects.
102
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This simple bacteria
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ended up killing
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almost one half the population
of the entire old empire.
105
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With that type of death toll,
106
00:05:32,624 --> 00:05:36,501
the economic and
social ramifications
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were catastrophic.
108
00:05:38,213 --> 00:05:42,299
Everything that
justinian had tried
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was now collapsing.
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His military collapsed,
his economy collapsed.
111
00:05:47,181 --> 00:05:50,140
And everything
that he tried to do
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00:05:50,184 --> 00:05:52,142
was of no avail.
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Justinian plague
is caused by a bacterium,
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yersinia pestis.
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It can either enter humans directly,
um, through...
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00:06:01,403 --> 00:06:03,362
From saliva or-or coughing.
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00:06:03,405 --> 00:06:05,072
It usually manifests itself
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00:06:05,157 --> 00:06:06,968
in terms of swelling
of the lymph nodes.
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00:06:06,992 --> 00:06:09,493
The skin turns black
and basically dies.
120
00:06:09,578 --> 00:06:11,014
And then there's a
progression of fever
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00:06:11,038 --> 00:06:12,954
and chills and eventual death.
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As justinian's empire
was collapsing and breaking
123
00:06:18,379 --> 00:06:21,463
and his military
strength was waning...
124
00:06:21,548 --> 00:06:24,257
Because the science of
medicine in those days
125
00:06:24,343 --> 00:06:27,636
was far more primitive
than we have today.
126
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People cry out, "why?
127
00:06:30,557 --> 00:06:32,349
Why is this happening?"
128
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The plague of justinian,
as it became known,
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ultimately killed an
estimated 50 million people.
130
00:06:40,067 --> 00:06:42,984
The vast byzantine
empire was crippled
131
00:06:43,070 --> 00:06:45,362
not by an invading army
132
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but by an enemy they could
not see and did not understand.
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At the time,
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00:06:53,539 --> 00:06:56,206
since the existence
of bacteria and viruses
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had not yet been discovered,
136
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many believed that the invisible
force that caused the plague
137
00:07:03,257 --> 00:07:05,424
was god himself.
138
00:07:05,509 --> 00:07:07,509
It was a belief that
was widely accepted,
139
00:07:07,594 --> 00:07:10,137
because people
would read in the bible
140
00:07:10,222 --> 00:07:13,056
about how pestilence
from the past
141
00:07:13,142 --> 00:07:16,351
had been created
by the hand of god.
142
00:07:18,480 --> 00:07:22,774
Whenever humanity is infected
143
00:07:22,818 --> 00:07:27,654
by something greater and
beyond human understanding,
144
00:07:27,739 --> 00:07:32,993
it has always been
psychologically understood
145
00:07:33,078 --> 00:07:38,165
to be an expression
of the wrath of god.
146
00:07:38,917 --> 00:07:41,084
We have in the book of exodus
147
00:07:41,128 --> 00:07:44,463
the famous ten plagues of egypt.
148
00:07:44,506 --> 00:07:49,718
Moses had come back after
seeing god on the mountain
149
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to free the hebrews
from slavery.
150
00:07:52,681 --> 00:07:57,100
He went before the pharaoh
and asked to let his people go.
151
00:07:57,186 --> 00:07:59,561
Of course, the pharaoh said no.
152
00:07:59,646 --> 00:08:04,232
Therefore, the hebrew god sent a
number of plagues through egypt.
153
00:08:07,654 --> 00:08:10,113
The bible stories are clear.
154
00:08:10,157 --> 00:08:14,826
The order of the plagues are
well-documented in the bible.
155
00:08:14,912 --> 00:08:16,703
We know, of course,
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00:08:16,788 --> 00:08:20,373
that there was the turning
of the nile into blood.
157
00:08:20,459 --> 00:08:22,250
There were the frogs, the lice,
158
00:08:22,336 --> 00:08:24,794
the pestilence and, of course,
159
00:08:24,880 --> 00:08:27,797
the great plagues of the
three days of darkness
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00:08:27,883 --> 00:08:30,675
and, of course,
the death of the firstborn.
161
00:08:32,679 --> 00:08:35,847
The biblical writer
who is writing what happens
162
00:08:35,933 --> 00:08:37,307
and is inspired by god
163
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does say that the plague stopped
164
00:08:39,353 --> 00:08:42,020
after the hebrews
were finally free.
165
00:08:42,064 --> 00:08:45,941
So, perhaps there was some
divine intervention from god.
166
00:08:46,026 --> 00:08:47,651
But we'll never know,
167
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because miracles are
very difficult to prove.
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Was there a
higher power involved
169
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that both started and
ended the plagues of egypt
170
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and the plague of justinian?
171
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Perhaps more clues as to
what causes devastating plagues
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00:09:03,418 --> 00:09:06,086
can be found by examining
the disease responsible
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00:09:06,171 --> 00:09:09,297
for claiming more
lives than any other.
174
00:09:20,519 --> 00:09:24,062
Officials from the california
odepartment of public health
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00:09:24,106 --> 00:09:27,899
alert residents that a
woman has tested positive
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00:09:27,943 --> 00:09:32,070
for a dangerous and
quite unexpected disease.
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The bubonic plague,
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00:09:35,284 --> 00:09:38,952
otherwise known
as the black death.
179
00:09:39,913 --> 00:09:42,455
Does the
bubonic plague still exist?
180
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The answer is... Yes.
181
00:09:45,085 --> 00:09:46,501
And it's amazing
182
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how, many centuries later,
183
00:09:49,381 --> 00:09:52,048
you could say this
with a calm voice.
184
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What is the difference?
185
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The answer is antibiotics.
186
00:09:56,763 --> 00:09:59,639
We know that if you
have symptoms early
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that antibiotics
can save your life.
188
00:10:03,353 --> 00:10:06,771
While it's not
as prevalent anymore,
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00:10:06,815 --> 00:10:10,775
the plague is certainly
still in circulation.
190
00:10:10,861 --> 00:10:12,547
In the united states,
right, in more rural areas,
191
00:10:12,571 --> 00:10:14,613
where people come into
contact with-with rodents
192
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that might be infected with it,
193
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it's still known to, like,
crop up here and there.
194
00:10:21,288 --> 00:10:24,247
The worst case of the
bubonic plague that there was
195
00:10:24,291 --> 00:10:26,124
was known as the black death,
196
00:10:26,168 --> 00:10:29,878
in the middle of the 1300s.
197
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And that wiped out
198
00:10:32,299 --> 00:10:38,136
60% of all of
europe's population.
199
00:10:42,476 --> 00:10:45,143
12 trade ships arrive
200
00:10:45,187 --> 00:10:46,978
from the black sea
201
00:10:47,022 --> 00:10:50,065
and drift into the port of
messina to unload freight.
202
00:10:50,150 --> 00:10:51,983
As dockworkers
203
00:10:52,069 --> 00:10:53,443
approach the vessels,
204
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they discover a
disturbing scene.
205
00:10:56,365 --> 00:10:59,282
The port master goes on board
206
00:10:59,368 --> 00:11:02,661
to see the crew, and,
to their surprise,
207
00:11:02,704 --> 00:11:05,330
it was almost like there
were zombies on the ship.
208
00:11:05,374 --> 00:11:08,500
Gangrene fingers.
209
00:11:08,543 --> 00:11:10,543
Big boils.
210
00:11:10,629 --> 00:11:11,836
And if I saw
211
00:11:11,922 --> 00:11:14,047
a crew that had black fingers
212
00:11:14,132 --> 00:11:15,757
and boils, let's be honest:
213
00:11:15,842 --> 00:11:18,343
It sounds like a
zombie apocalypse.
214
00:11:18,428 --> 00:11:21,262
The black death seemed
to have been introduced
215
00:11:21,348 --> 00:11:22,138
via the silk road,
216
00:11:22,224 --> 00:11:24,516
which is a major trading route
217
00:11:24,601 --> 00:11:27,519
in the early medieval
period from central asia
218
00:11:27,604 --> 00:11:30,647
where the bubonic
plague regularly pops up.
219
00:11:30,732 --> 00:11:32,899
Europe seems to have
been largely unprepared
220
00:11:32,984 --> 00:11:34,484
for this devastating event.
221
00:11:34,528 --> 00:11:36,152
This is in the 1300s.
222
00:11:36,196 --> 00:11:37,696
It went for quite a few years,
223
00:11:37,739 --> 00:11:41,866
and whole villages and
areas were wiped out.
224
00:11:41,910 --> 00:11:45,245
And like many plagues,
uh, people wondered why.
225
00:11:45,330 --> 00:11:47,475
These cities
would get the plague,
226
00:11:47,499 --> 00:11:49,040
and no one knew why.
227
00:11:49,084 --> 00:11:50,770
And then we always
have the advantage
228
00:11:50,794 --> 00:11:54,129
of looking back on
history and tracing.
229
00:11:54,214 --> 00:11:56,234
Historians could look back and say,
"wait a minute.
230
00:11:56,258 --> 00:11:58,258
"all the cities with ports
231
00:11:58,343 --> 00:12:00,719
"that do a lot of
trading were infected.
232
00:12:00,804 --> 00:12:04,723
And what were going
to all these ports? Ships."
233
00:12:05,517 --> 00:12:07,851
The black death
234
00:12:07,936 --> 00:12:10,228
was spread by fleas
that lived on rats.
235
00:12:10,272 --> 00:12:13,565
And wherever these rats went,
the fleas went,
236
00:12:13,650 --> 00:12:16,192
and they bit people.
That's what made them ill.
237
00:12:16,278 --> 00:12:19,090
The flea
would actually vomit the bacteria
238
00:12:19,114 --> 00:12:21,322
onto the person's
skin while biting them.
239
00:12:22,242 --> 00:12:24,492
The disease spreads to
the body's lymph nodes
240
00:12:24,578 --> 00:12:26,202
and causes buboes,
241
00:12:26,246 --> 00:12:27,579
which are infected sores
242
00:12:27,622 --> 00:12:29,748
which get to be about
the size of an egg.
243
00:12:29,791 --> 00:12:33,209
And they eventually
burst and expel bloody pus.
244
00:12:33,253 --> 00:12:35,170
The body goes through
245
00:12:35,255 --> 00:12:37,172
such horrific and
gruesome transformations
246
00:12:37,257 --> 00:12:41,259
that from the time you contract
the bubonic plague until death
247
00:12:41,344 --> 00:12:43,344
can sometimes only
be a matter of days.
248
00:12:43,430 --> 00:12:46,264
During the middle ages,
many believed
249
00:12:46,308 --> 00:12:49,601
that demons were
responsible for the black death.
250
00:12:49,686 --> 00:12:51,936
- - and people who were deemed
251
00:12:52,022 --> 00:12:54,856
to be wicked or unworthy
252
00:12:54,941 --> 00:12:56,274
were punished
253
00:12:56,318 --> 00:12:59,736
in hopes of driving
the demons away.
254
00:13:01,907 --> 00:13:04,783
Many people believed
255
00:13:04,868 --> 00:13:08,495
that the source of this plague
256
00:13:08,580 --> 00:13:10,830
was caused by evil spirits,
257
00:13:10,916 --> 00:13:13,792
witchcraft and the like.
258
00:13:15,295 --> 00:13:17,003
The powers of the occult.
259
00:13:17,088 --> 00:13:20,089
And this led many people
260
00:13:20,175 --> 00:13:23,510
to seek out any
type of expressions
261
00:13:23,595 --> 00:13:26,763
of the occult,
witchcraft and the like...
262
00:13:28,391 --> 00:13:29,974
...And to root it out
263
00:13:30,060 --> 00:13:33,436
in the attempt to placate god.
264
00:13:37,692 --> 00:13:39,796
Some were so
convinced that the black death
265
00:13:39,820 --> 00:13:42,487
was a scourge
brought by evil spirits,
266
00:13:42,572 --> 00:13:47,784
they were willing to
scourge themselves.
267
00:13:49,079 --> 00:13:51,432
One common occurrence
during the time of the black death
268
00:13:51,456 --> 00:13:55,542
was to see, uh, people that
were called flagellants, which...
269
00:13:55,627 --> 00:13:57,647
They were under the belief
that they were being punished
270
00:13:57,671 --> 00:14:00,797
by god for their sins,
so they would publicly atone,
271
00:14:00,882 --> 00:14:03,299
and they would March
through the town square,
272
00:14:03,385 --> 00:14:06,177
flogging themselves
in the name of god.
273
00:14:11,101 --> 00:14:13,643
This flagellation
movement really exploded.
274
00:14:13,728 --> 00:14:16,187
Whole towns
flagellating themselves.
275
00:14:16,231 --> 00:14:18,565
Those that didn't were
accused of being with the devil.
276
00:14:19,568 --> 00:14:23,903
Something else that
came from the black death was
277
00:14:23,989 --> 00:14:27,448
the practice of
selling holy relics.
278
00:14:27,534 --> 00:14:31,786
When the black death
was decimating europe,
279
00:14:31,872 --> 00:14:34,372
the church were saying,
280
00:14:34,416 --> 00:14:35,915
"come to us,
281
00:14:36,001 --> 00:14:38,543
and we can cure you."
282
00:14:38,587 --> 00:14:40,295
the bones of a saint
283
00:14:40,380 --> 00:14:43,047
or something that had
once belonged to a saint
284
00:14:43,091 --> 00:14:45,383
kept in these churches.
They were called relics.
285
00:14:45,427 --> 00:14:47,488
And people believed
that if they went there
286
00:14:47,512 --> 00:14:49,095
or close to such relics,
287
00:14:49,180 --> 00:14:51,222
prayed, that god may intervene
288
00:14:51,266 --> 00:14:53,266
and protect them
from the plague.
289
00:14:53,351 --> 00:14:55,727
Now, they weren't curing anyone,
290
00:14:55,812 --> 00:14:59,397
but people were still
flocking to the churches
291
00:14:59,441 --> 00:15:02,567
just on the hope that
they could be cured.
292
00:15:03,570 --> 00:15:06,237
So,
when we talk about the many lives
293
00:15:06,281 --> 00:15:08,698
that were lost during
the black death,
294
00:15:08,742 --> 00:15:10,325
I think about a horror movie.
295
00:15:11,286 --> 00:15:13,764
Historians
estimate that the black death
296
00:15:13,788 --> 00:15:17,540
wiped out anywhere from
50 to 200 million people,
297
00:15:17,626 --> 00:15:20,209
at least a third of
europe's population.
298
00:15:20,253 --> 00:15:22,253
So it's little wonder
299
00:15:22,297 --> 00:15:24,756
that most people thought
that something so destructive
300
00:15:24,841 --> 00:15:28,259
must have been some
kind of punishment from god.
301
00:15:28,303 --> 00:15:31,679
But today,
we have a much different understanding
302
00:15:31,765 --> 00:15:33,431
of this disease.
303
00:15:33,475 --> 00:15:35,266
We call it the black death,
304
00:15:35,352 --> 00:15:38,436
but it's-it's a bacteria
called
yersinia pestis.
305
00:15:38,521 --> 00:15:42,482
But it's not as
dangerous as it was then.
306
00:15:42,567 --> 00:15:45,151
Now we have antibiotics.
307
00:15:45,236 --> 00:15:46,945
We can detect it.
308
00:15:47,030 --> 00:15:48,905
You know, you can treat it.
309
00:15:50,867 --> 00:15:52,575
In any case,
310
00:15:52,661 --> 00:15:56,079
yersinia pestis is
still around today,
311
00:15:56,122 --> 00:15:58,706
which begs the question,
312
00:15:58,792 --> 00:16:00,249
is it possible
313
00:16:00,335 --> 00:16:02,961
to actually kill
off a fatal disease
314
00:16:03,004 --> 00:16:04,295
once and for all?
315
00:16:04,339 --> 00:16:05,630
Perhaps the answer can be found
316
00:16:05,674 --> 00:16:07,924
by examining a deadly plague
317
00:16:07,968 --> 00:16:09,634
that, believe it or not,
318
00:16:09,678 --> 00:16:12,470
has been infecting humankind
319
00:16:12,514 --> 00:16:15,974
for more than 10,000 years.
320
00:16:22,857 --> 00:16:24,816
The valley of mexico.
321
00:16:29,531 --> 00:16:33,241
Spanish conquistadors
led by hernán cortés
322
00:16:33,326 --> 00:16:36,911
arrive at tenochtitlán,
the capital of the aztec empire,
323
00:16:36,997 --> 00:16:39,455
bearing dreams of conquest
324
00:16:39,541 --> 00:16:42,166
and an insatiable
desire for gold.
325
00:16:42,252 --> 00:16:47,338
But they also brought with them a lethal,
infectious disease.
326
00:16:47,382 --> 00:16:49,465
Smallpox is introduced
327
00:16:49,551 --> 00:16:53,011
into the americas
very dramatically
328
00:16:53,054 --> 00:16:54,115
at a specific point in time
329
00:16:54,139 --> 00:16:56,556
and alongside the
european invasion.
330
00:16:56,641 --> 00:17:00,685
This is a tremendous
sort of clash of civilizations,
331
00:17:00,729 --> 00:17:03,479
the likes of which the
world had never seen before
332
00:17:03,565 --> 00:17:04,731
and will never see again.
333
00:17:04,816 --> 00:17:08,860
The single most deciding factor
334
00:17:08,903 --> 00:17:13,072
as to why native american
civilizations fell so rapidly
335
00:17:13,158 --> 00:17:14,918
was the introduction
of smallpox.
336
00:17:17,871 --> 00:17:20,371
So, smallpox is a virus.
337
00:17:20,415 --> 00:17:24,250
It causes these sort
of irregularly spaced,
338
00:17:24,335 --> 00:17:26,878
pustule-y skin lesions
339
00:17:26,921 --> 00:17:28,379
and had a devastating effect
340
00:17:28,465 --> 00:17:31,841
on-on native americans,
um, in the new world.
341
00:17:32,802 --> 00:17:37,055
In europe,
most people had experienced smallpox.
342
00:17:37,098 --> 00:17:38,723
They had the scars,
343
00:17:38,767 --> 00:17:40,183
or they had it as children.
344
00:17:40,268 --> 00:17:43,519
But there was no
immunity in the new world.
345
00:17:43,563 --> 00:17:45,688
There was no
immunity among kids.
346
00:17:45,774 --> 00:17:47,899
There was no
immunity among adults.
347
00:17:47,942 --> 00:17:51,027
And so,
when this new disease came,
348
00:17:51,112 --> 00:17:53,696
everybody was vulnerable.
349
00:17:53,740 --> 00:17:56,115
And so it spread like wildfire.
350
00:17:57,410 --> 00:18:00,203
Although the exact
numbers will never be known,
351
00:18:00,246 --> 00:18:02,163
many experts estimate
352
00:18:02,248 --> 00:18:05,666
that a staggering 95% of
the indigenous population
353
00:18:05,752 --> 00:18:08,878
would eventually
die from smallpox.
354
00:18:08,922 --> 00:18:11,214
But what's even more chilling
355
00:18:11,257 --> 00:18:13,883
is the fact that
smallpox ran rampant
356
00:18:13,968 --> 00:18:16,260
for thousands of years.
357
00:18:16,304 --> 00:18:19,806
I am astounded
358
00:18:19,891 --> 00:18:23,059
by how far back smallpox goes.
359
00:18:23,103 --> 00:18:25,937
For most of human
recorded history,
360
00:18:25,980 --> 00:18:27,772
we believe it's the same strain
361
00:18:27,857 --> 00:18:30,149
that was infecting one
person after another,
362
00:18:30,235 --> 00:18:32,527
this human chain of infection.
363
00:18:32,612 --> 00:18:38,908
The egyptian pharaoh ramses
v had scarring on his face
364
00:18:38,993 --> 00:18:41,744
that's consistent with smallpox.
365
00:18:44,791 --> 00:18:47,416
It is estimated
that smallpox has killed
366
00:18:47,460 --> 00:18:49,961
between 300 and
500 million people
367
00:18:50,046 --> 00:18:53,840
in its more than
10,000-year existence.
368
00:18:53,925 --> 00:18:57,802
How did we finally beat it?
369
00:19:00,682 --> 00:19:03,349
Well, it just so happens
that the cure for smallpox
370
00:19:03,434 --> 00:19:08,479
was discovered in a small
english village in the 1790s.
371
00:19:08,523 --> 00:19:12,358
In the late 1700s,
doctors were noticing
372
00:19:12,443 --> 00:19:16,612
that milkmaids did not seem
to be affected by smallpox,
373
00:19:16,698 --> 00:19:21,325
and their complexions
remained unscarred.
374
00:19:21,411 --> 00:19:25,413
And people were starting
to make that connection
375
00:19:25,498 --> 00:19:29,000
that there might be
immunity from catching
376
00:19:29,043 --> 00:19:33,171
a different kind of pox virus,
cow pox.
377
00:19:33,214 --> 00:19:37,133
So milkmaids were
exposed to the cow pox virus,
378
00:19:37,177 --> 00:19:39,218
probably got infected,
379
00:19:39,304 --> 00:19:42,180
and were then
immune to smallpox.
380
00:19:44,017 --> 00:19:45,911
Edward jenner was
an english physician,
381
00:19:45,935 --> 00:19:49,520
and decided to
test this observation,
382
00:19:49,606 --> 00:19:52,815
and took a piece of
an ulcer from a cow
383
00:19:52,859 --> 00:19:55,026
that was infected by cow pox,
384
00:19:55,069 --> 00:19:58,696
and gave it to an
eight-year-old boy.
385
00:19:58,781 --> 00:20:01,657
And then, a little bit later,
386
00:20:01,743 --> 00:20:05,703
gave this little boy
a dose of smallpox.
387
00:20:05,788 --> 00:20:10,374
Fortunately, the eight-year-old
boy did not develop smallpox
388
00:20:10,418 --> 00:20:13,502
and was actually protected.
389
00:20:13,546 --> 00:20:16,130
Because it wasn't, like,
a direct viral intake,
390
00:20:16,216 --> 00:20:19,967
you would get, like,
a slightly lesser version of the disease.
391
00:20:20,053 --> 00:20:22,094
But because you had
been exposed to it,
392
00:20:22,180 --> 00:20:24,722
you would, of course,
then have immunity.
393
00:20:24,766 --> 00:20:26,702
So it was probably
the first instance
394
00:20:26,726 --> 00:20:29,060
of a crude version
of vaccination.
395
00:20:30,438 --> 00:20:33,689
As it turns out,
edward jenner's revolutionary experiment
396
00:20:33,775 --> 00:20:36,651
is remembered today
for its inspiration,
397
00:20:36,736 --> 00:20:39,570
its sheer audacity
398
00:20:39,614 --> 00:20:42,073
and because it
provided a new defense
399
00:20:42,116 --> 00:20:43,699
against infectious disease,
400
00:20:43,743 --> 00:20:48,913
which we now refer
to as "the vaccine."
401
00:20:48,998 --> 00:20:52,416
the word "vaccine" comes
from the virus name "vaccinia,"
402
00:20:52,502 --> 00:20:57,421
which was the virus that
was the cow pox-derived virus
403
00:20:57,465 --> 00:21:00,716
that left people
immune to smallpox.
404
00:21:00,802 --> 00:21:04,220
Vaccines prevent disease,
405
00:21:04,305 --> 00:21:07,265
and some vaccines
can last for decades,
406
00:21:07,308 --> 00:21:11,602
and some vaccines need
to be given every year.
407
00:21:11,646 --> 00:21:15,648
For smallpox, people had to
get vaccinated every ten years.
408
00:21:16,943 --> 00:21:20,361
Vaccines are
humanity's single greatest weapon
409
00:21:20,446 --> 00:21:22,280
against plagues.
410
00:21:22,365 --> 00:21:25,116
Rooted in science
and not superstition,
411
00:21:25,159 --> 00:21:28,995
they provide a powerful
way to fight outbreaks.
412
00:21:29,080 --> 00:21:31,497
The last naturally
occurring case of smallpox
413
00:21:31,582 --> 00:21:35,626
was identified in 1979,
and in 1980,
414
00:21:35,712 --> 00:21:37,503
the world health
organization declared
415
00:21:37,588 --> 00:21:39,630
that smallpox was eradicated.
416
00:21:39,674 --> 00:21:43,009
So no longer spreading
from person to person.
417
00:21:43,094 --> 00:21:47,346
Eradicating smallpox was
the biggest public health victory
418
00:21:47,432 --> 00:21:50,433
in the history of
the human race.
419
00:21:51,561 --> 00:21:54,645
The eradication of
smallpox is the most famous use
420
00:21:54,731 --> 00:21:57,231
of a highly-effective vaccine,
421
00:21:57,317 --> 00:22:01,777
but there are some diseases
that are harder to cure.
422
00:22:01,821 --> 00:22:03,988
There are viruses
423
00:22:04,032 --> 00:22:06,157
for which we have
no vaccines at all,
424
00:22:06,242 --> 00:22:08,200
because they mutate too rapidly.
425
00:22:08,286 --> 00:22:11,454
And so, because viruses mutate,
426
00:22:11,539 --> 00:22:15,333
there's a certain limitation to
what you can do with vaccines.
427
00:22:17,211 --> 00:22:19,420
The minute
you get too confident,
428
00:22:19,505 --> 00:22:22,131
and you think that we
defeated mother nature,
429
00:22:22,216 --> 00:22:25,176
somehow,
it always finds a way to come back.
430
00:22:25,261 --> 00:22:27,553
Vaccines are one of mankind's
431
00:22:27,638 --> 00:22:29,805
greatest scientific triumphs.
432
00:22:29,849 --> 00:22:32,058
But not all medical recoveries
433
00:22:32,143 --> 00:22:34,143
can be easily
explained by science.
434
00:22:34,187 --> 00:22:37,188
Sometimes, the body's reaction
435
00:22:37,273 --> 00:22:40,858
to an infection is so
bizarre and so inexplicable
436
00:22:40,902 --> 00:22:44,362
that it can only
be described as...
437
00:22:44,405 --> 00:22:50,201
Miraculous.
438
00:22:50,286 --> 00:22:52,787
July 4, 1863.
439
00:22:52,872 --> 00:22:55,247
Gettysburg, pennsylvania.
440
00:22:55,333 --> 00:22:57,144
On the morning after
the bloodiest battle
441
00:22:57,168 --> 00:22:58,542
of the civil war,
442
00:22:58,628 --> 00:23:01,712
thousands of dead
soldiers lay strewn
443
00:23:01,798 --> 00:23:04,006
across the
blood-soaked farmland.
444
00:23:04,092 --> 00:23:08,677
But while the brutality of the
civil war is well-documented,
445
00:23:08,763 --> 00:23:11,430
approximately
two-thirds of the more
446
00:23:11,516 --> 00:23:13,766
than 600,000 deaths in the war
447
00:23:13,851 --> 00:23:17,812
weren't caused by injuries
sustained on the battlefield,
448
00:23:17,897 --> 00:23:20,898
but rather... By disease.
449
00:23:23,569 --> 00:23:25,528
The civil war represents
450
00:23:25,571 --> 00:23:30,074
the last major conflict that,
um, that humans experienced
451
00:23:30,159 --> 00:23:33,035
um, before the,
sort of, the inception
452
00:23:33,079 --> 00:23:34,703
or the origins of germ theory.
453
00:23:34,747 --> 00:23:37,415
You can imagine the conditions
454
00:23:37,500 --> 00:23:40,543
that soldiers live in,
crowded together,
455
00:23:40,628 --> 00:23:42,503
substandard sanitation.
456
00:23:42,588 --> 00:23:44,588
In some cases,
457
00:23:44,632 --> 00:23:47,258
open wounds that aren't
being treated correctly.
458
00:23:47,301 --> 00:23:49,260
It's really gross.
459
00:23:49,303 --> 00:23:51,053
Everything smells terrible.
460
00:23:51,097 --> 00:23:53,597
Uh,
these doctors aren't washing their aprons.
461
00:23:53,683 --> 00:23:57,601
They can't explain where they're
getting these diseases from,
462
00:23:57,687 --> 00:23:59,478
how they may be spreading it.
463
00:23:59,564 --> 00:24:02,857
As uncontrollable
infections ravaged
464
00:24:02,942 --> 00:24:05,943
both union and
confederate encampments,
465
00:24:05,987 --> 00:24:09,405
soldiers and their
doctors debated the cause
466
00:24:09,449 --> 00:24:11,115
of their afflictions.
467
00:24:11,159 --> 00:24:17,121
Many came to believe that
the air itself was poisoned.
468
00:24:17,165 --> 00:24:19,123
When we talk about
469
00:24:19,167 --> 00:24:22,084
some of the deadliest
viruses that we know,
470
00:24:22,170 --> 00:24:27,131
some of them get transmitted
by respiratory droplets, the air.
471
00:24:27,175 --> 00:24:32,136
When you cough,
when you sneeze, just by talking.
472
00:24:32,180 --> 00:24:36,307
So maybe they weren't too
off by saying the air is bad.
473
00:24:37,226 --> 00:24:39,810
In the mid-nineteenth century,
474
00:24:39,896 --> 00:24:41,979
little was known
about disease control
475
00:24:42,064 --> 00:24:45,316
or preventing the
spread of germs.
476
00:24:45,401 --> 00:24:48,611
But as the scope
of the war widened
477
00:24:48,696 --> 00:24:51,947
and the ferocity of
infectious outbreaks resulted
478
00:24:51,991 --> 00:24:54,450
in even more
horrific causalities,
479
00:24:54,494 --> 00:24:58,996
doctors were forced to expand
their knowledge of diseases
480
00:24:59,081 --> 00:25:01,081
and how to contain them.
481
00:25:01,167 --> 00:25:03,083
They realize that
482
00:25:03,169 --> 00:25:06,170
maybe a barn isn't the
best place to be doing
483
00:25:06,214 --> 00:25:09,298
amputations and open surgeries.
484
00:25:09,383 --> 00:25:11,842
So, as the war goes on,
485
00:25:11,928 --> 00:25:13,697
there's beginning to
be an understanding
486
00:25:13,721 --> 00:25:15,346
of what medicine should be.
487
00:25:15,389 --> 00:25:16,972
Things like triage,
488
00:25:17,058 --> 00:25:20,601
things like an ambulance system,
hospitals...
489
00:25:20,686 --> 00:25:22,539
These are all established
during the civil war
490
00:25:22,563 --> 00:25:24,374
in the united states
for the first time.
491
00:25:24,398 --> 00:25:27,191
In many ways,
the civil war marked the beginning
492
00:25:27,276 --> 00:25:28,984
of medical science as we know it
493
00:25:29,028 --> 00:25:31,362
and the end of mankind's
494
00:25:31,405 --> 00:25:34,573
superstitious attitude
towards disease.
495
00:25:34,659 --> 00:25:37,368
But there is one
event on the battlefield
496
00:25:37,453 --> 00:25:40,996
that medical historians still
struggle to explain to this day,
497
00:25:41,082 --> 00:25:44,375
because it simply
defies understanding.
498
00:25:48,214 --> 00:25:52,550
April 7, 1862,
hardin county, tennessee.
499
00:25:52,593 --> 00:25:56,053
Union and confederate
forces square off
500
00:25:56,138 --> 00:25:58,055
in one of the
bloodiest confrontations
501
00:25:58,140 --> 00:26:01,225
of the civil war...
The battle of shiloh.
502
00:26:03,187 --> 00:26:06,063
After two days of
vicious fighting...
503
00:26:08,401 --> 00:26:13,529
...More than 20,000
men lie dead or dying.
504
00:26:14,657 --> 00:26:17,199
So,
ulysses s. Grant is the commander
505
00:26:17,285 --> 00:26:18,554
of the union
army at this battle.
506
00:26:18,578 --> 00:26:20,681
He went out,
and looked over the battlefield,
507
00:26:20,705 --> 00:26:24,415
and he could see that there were
so many soldiers who had been
508
00:26:24,458 --> 00:26:27,418
wounded and killed that he
could have walked across one side
509
00:26:27,461 --> 00:26:28,877
of the battlefield to the other
510
00:26:28,963 --> 00:26:30,399
without ever
touching the ground,
511
00:26:30,423 --> 00:26:33,424
walking from body
to body to body.
512
00:26:33,467 --> 00:26:37,136
As night
falls over the battlefield,
513
00:26:37,221 --> 00:26:40,222
many injured
soldiers lie helpless,
514
00:26:40,266 --> 00:26:43,601
hoping to be rescued before
their wounds become infected.
515
00:26:43,686 --> 00:26:47,730
What happens next is one
of the enduring mysteries
516
00:26:47,815 --> 00:26:49,607
of the civil war.
517
00:26:49,650 --> 00:26:52,735
Soldiers are
out between the lines,
518
00:26:52,820 --> 00:26:54,778
wounded during the
course of the battle.
519
00:26:54,822 --> 00:26:57,072
It's cold at night. They're
out there shivering.
520
00:26:57,116 --> 00:27:01,368
And they happen to look down
at their shattered arm or leg,
521
00:27:01,454 --> 00:27:06,540
and they notice this soft,
faint, bluish-greenish glow
522
00:27:06,626 --> 00:27:09,001
seeming to come off their
wounds in the darkness.
523
00:27:09,086 --> 00:27:12,546
There was a connection that was
being made amongst the soldiers
524
00:27:12,632 --> 00:27:16,592
that those who experienced
this glowing wound effect
525
00:27:16,636 --> 00:27:19,303
seemed to have better outcomes
526
00:27:19,347 --> 00:27:21,722
when they went back to the field hospital,
and it seemed
527
00:27:21,807 --> 00:27:25,309
as though their wounds may
not have been as infected.
528
00:27:25,353 --> 00:27:29,938
They termed
this bluish-green glow
529
00:27:29,982 --> 00:27:32,441
angel's glow. Why?
530
00:27:32,526 --> 00:27:35,611
Because, to them,
it looked like a halo.
531
00:27:35,655 --> 00:27:38,322
Mystical light surrounding them.
532
00:27:38,366 --> 00:27:40,491
So,
it was a way of them thinking that god
533
00:27:40,534 --> 00:27:43,494
or the angels were protecting
these particular soldiers.
534
00:27:43,579 --> 00:27:46,872
Was the so-called angel's glow
535
00:27:46,957 --> 00:27:49,041
a type of divine intervention
536
00:27:49,126 --> 00:27:53,253
that somehow protected certain
soldiers from deadly infections?
537
00:27:53,339 --> 00:27:57,466
Perhaps. But recently,
a new theory has surfaced...
538
00:27:57,551 --> 00:27:59,802
One that suggests
this phenomenon
539
00:27:59,845 --> 00:28:05,099
may have had a more
conventional explanation.
540
00:28:05,184 --> 00:28:08,268
It wasn't until many years,
like 150 years later,
541
00:28:08,354 --> 00:28:12,523
that a 17-year-old high
school student visited shiloh,
542
00:28:12,608 --> 00:28:14,983
and he decided for
his science project
543
00:28:15,027 --> 00:28:17,861
to research
bacterium that glows.
544
00:28:17,947 --> 00:28:21,699
And they were able to find
out that there was a bacteria
545
00:28:21,784 --> 00:28:24,702
that would emit some
sort of parasitic worm.
546
00:28:24,745 --> 00:28:27,663
It would get into the veins,
and then it would glow.
547
00:28:27,748 --> 00:28:30,874
Could the angel's glow
548
00:28:30,918 --> 00:28:33,544
really have been a
sign of a type of bacteria,
549
00:28:33,587 --> 00:28:36,004
rather than guardian angels?
550
00:28:36,090 --> 00:28:39,842
And if so, could this bacteria
have actually been responsible
551
00:28:39,927 --> 00:28:43,971
for saving the lives of
the wounded soldiers?
552
00:28:44,056 --> 00:28:46,181
Presumably,
what happened with those soldiers
553
00:28:46,225 --> 00:28:47,891
with the angel's glow
554
00:28:47,935 --> 00:28:51,228
is that those bacteria were
actually infecting their wounds.
555
00:28:51,272 --> 00:28:54,857
And because those bacteria
exude a lot of antibacterial
556
00:28:54,900 --> 00:28:58,235
and antimicrobial compounds,
they actually reduce the level
557
00:28:58,279 --> 00:28:59,695
of infection in the soldiers
558
00:28:59,780 --> 00:29:02,448
that they, that they,
uh, colonized.
559
00:29:03,284 --> 00:29:04,469
The bacteria theory
560
00:29:04,493 --> 00:29:07,578
is the best scientific
explanation we have
561
00:29:07,663 --> 00:29:11,039
for what caused
the angel's glow.
562
00:29:11,125 --> 00:29:13,167
If this incredible
theory is true,
563
00:29:13,252 --> 00:29:16,170
then it seems that
some forms of bacteria
564
00:29:16,255 --> 00:29:19,923
can actually help us in
the fight against disease.
565
00:29:19,967 --> 00:29:22,593
But the soldiers
whose lives were saved
566
00:29:22,636 --> 00:29:26,764
at the battle of shiloh
believed that what healed them
567
00:29:26,807 --> 00:29:30,100
could only have been
sent from heaven.
568
00:29:30,144 --> 00:29:31,788
We can't know what
those soldiers experienced
569
00:29:31,812 --> 00:29:35,105
out there on the battlefield
between the lines.
570
00:29:35,191 --> 00:29:37,775
They're in the dark,
they're suffering from shock.
571
00:29:37,818 --> 00:29:39,777
Who's to say that they
didn't experience that
572
00:29:39,820 --> 00:29:42,571
or that they did
experience that?
573
00:29:44,074 --> 00:29:47,743
Guardian angels,
reaching down to comfort
574
00:29:47,787 --> 00:29:52,247
and even cure dying soldiers
during the american civil war?
575
00:29:52,291 --> 00:29:55,417
To some it sounds
like pure fantasy.
576
00:29:55,503 --> 00:29:58,045
But to others, especially those
577
00:29:58,130 --> 00:30:01,381
who've had their own
close calls with death,
578
00:30:01,467 --> 00:30:05,969
there's no doubt that such
a notion is entirely plausible.
579
00:30:06,055 --> 00:30:08,639
When dealing
with deadly diseases,
580
00:30:08,724 --> 00:30:11,183
it's hard to be certain
of pretty much anything.
581
00:30:11,268 --> 00:30:15,103
Not only do we
often know very little
582
00:30:15,147 --> 00:30:17,105
about how to cure an illness,
583
00:30:17,191 --> 00:30:20,609
we know even less about
where an illness comes from.
584
00:30:20,653 --> 00:30:22,986
For instance, what if I told you
585
00:30:23,030 --> 00:30:26,782
that what we commonly
refer to as the spanish flu
586
00:30:26,867 --> 00:30:31,662
didn't come from Spain at all,
but from a remote army base...
587
00:30:33,374 --> 00:30:35,332
...In kansas?
588
00:30:46,554 --> 00:30:48,929
At the height of world war I,
589
00:30:49,014 --> 00:30:52,683
more than 50 years after the
end of the american civil war,
590
00:30:52,768 --> 00:30:56,645
soldiers from more than
30 nations are engaged
591
00:30:56,689 --> 00:30:59,356
in trench warfare
all over europe...
592
00:31:00,776 --> 00:31:04,361
...And a new,
unexpected enemy emerges...
593
00:31:04,405 --> 00:31:07,364
...The spanish flu.
594
00:31:08,409 --> 00:31:09,719
Europe is awash
595
00:31:09,743 --> 00:31:12,452
in the influenza virus.
596
00:31:12,538 --> 00:31:16,540
They had a massive
outbreak of influenza,
597
00:31:16,584 --> 00:31:19,334
and these soldiers
serving at the front lines
598
00:31:19,420 --> 00:31:22,546
are directly impacted on
both sides of the conflict.
599
00:31:22,590 --> 00:31:25,966
- -the symptoms
were pretty horrific,
600
00:31:26,051 --> 00:31:27,946
and so these soldiers were
not capable of performing
601
00:31:27,970 --> 00:31:30,888
their duties, and many of
them actually die of the disease.
602
00:31:32,391 --> 00:31:35,642
We're used to the flu,
but the 1918 flu
603
00:31:35,728 --> 00:31:39,521
had more severe symptoms
and lingering effects.
604
00:31:40,774 --> 00:31:43,025
When the flu first
started spreading,
605
00:31:43,110 --> 00:31:46,236
their skin turned blue.
606
00:31:46,322 --> 00:31:49,239
They just had no
oxygen in their blood.
607
00:31:49,283 --> 00:31:52,910
It was not uncommon for
people to lose all their hair.
608
00:31:52,953 --> 00:31:57,247
It was not uncommon to
have neurological side effects.
609
00:31:58,500 --> 00:32:00,792
The 1918 influenza strain
610
00:32:00,878 --> 00:32:04,296
caused an incredibly high fever,
it caused coughing.
611
00:32:04,381 --> 00:32:08,216
In many cases,
patients' lungs would fill with fluid
612
00:32:08,302 --> 00:32:10,102
as this virus is
taking over their body.
613
00:32:10,179 --> 00:32:13,305
That would cause an
immune system overreaction
614
00:32:13,390 --> 00:32:15,265
and they would
essentially drown.
615
00:32:16,810 --> 00:32:18,204
Medics on the front lines,
616
00:32:18,228 --> 00:32:20,020
prepared for the ravages of war,
617
00:32:20,105 --> 00:32:24,232
look on in horror as young,
healthy soldiers
618
00:32:24,318 --> 00:32:26,193
begin to die within days,
619
00:32:26,278 --> 00:32:29,905
or even hours of
showing symptoms.
620
00:32:29,949 --> 00:32:34,743
The spanish flu was caused by,
um, an h1n1 influenza virus.
621
00:32:34,828 --> 00:32:37,871
And the particular
strain of the h1n1 virus
622
00:32:37,957 --> 00:32:40,624
was a little unusual
amongst influenza viruses
623
00:32:40,668 --> 00:32:43,961
in that it was much more contagious,
it was much easier
624
00:32:44,004 --> 00:32:46,088
to expel and spread
between people.
625
00:32:46,131 --> 00:32:49,049
In 1918, we still really were
626
00:32:49,134 --> 00:32:51,635
sort of incapable of
stopping its spread.
627
00:32:51,679 --> 00:32:54,221
This was right at the
end of world war I,
628
00:32:54,306 --> 00:32:57,516
and so soldiers were, of course,
kept in close quarters
629
00:32:57,601 --> 00:32:59,059
and barracks together.
630
00:32:59,103 --> 00:33:02,479
And then, also,
people were sort of moving around the world
631
00:33:02,523 --> 00:33:04,167
more than they probably
normally would have been
632
00:33:04,191 --> 00:33:05,649
sort of traveling.
633
00:33:05,734 --> 00:33:08,652
Um,
and so those were some of the factors
634
00:33:08,696 --> 00:33:10,821
that caused it to
spread really rapidly.
635
00:33:10,864 --> 00:33:14,408
Since finding a
cure for a mysterious virus
636
00:33:14,493 --> 00:33:17,452
in the midst of a
world war is a difficult,
637
00:33:17,496 --> 00:33:19,496
if not impossible undertaking,
638
00:33:19,581 --> 00:33:23,417
both the central powers
and the allied powers
639
00:33:23,502 --> 00:33:25,335
decided the best
course of action
640
00:33:25,379 --> 00:33:29,798
was to downplay the
threat posed by the disease.
641
00:33:29,883 --> 00:33:33,468
In fact,
the 1918 flu is called the spanish flu
642
00:33:33,554 --> 00:33:36,805
not because it came from Spain,
but because,
643
00:33:36,890 --> 00:33:40,308
initially,
Spain was the only country willing
644
00:33:40,352 --> 00:33:42,352
to acknowledge its existence.
645
00:33:45,524 --> 00:33:47,752
The reason we
think of it as the spanish flu
646
00:33:47,776 --> 00:33:50,652
is because Spain had
a free press at that time,
647
00:33:50,738 --> 00:33:54,031
and the rest of
the world did not.
648
00:33:54,074 --> 00:33:56,783
Spain was not
involved in world war I,
649
00:33:56,869 --> 00:34:00,370
and their king ended
up getting the 1918 flu.
650
00:34:00,456 --> 00:34:02,225
So it was a matter
of national interest,
651
00:34:02,249 --> 00:34:06,084
and most americans
learned of the flu
652
00:34:06,170 --> 00:34:08,211
from the spanish papers.
653
00:34:10,716 --> 00:34:14,384
The so-called spanish
flu is estimated to have infected
654
00:34:14,428 --> 00:34:17,721
one third of the world's
population at the time,
655
00:34:17,765 --> 00:34:19,723
roughly 500 million people.
656
00:34:19,808 --> 00:34:23,310
But while the press
created a lasting nickname
657
00:34:23,395 --> 00:34:24,811
for the 1918 flu,
658
00:34:24,897 --> 00:34:29,066
some researchers have
suggested that it actually originated
659
00:34:29,151 --> 00:34:32,569
in the heartland
of the united states.
660
00:34:36,658 --> 00:34:38,909
March 4, 1918.
661
00:34:38,994 --> 00:34:40,994
Fort riley, kansas.
662
00:34:41,080 --> 00:34:46,416
Before the so-called spanish flu
outbreak was reported in europe,
663
00:34:46,502 --> 00:34:50,754
a private at this remote
army base in the united states
664
00:34:50,798 --> 00:34:54,925
starts to feel ill.
665
00:34:54,968 --> 00:34:58,428
In March of 1918,
an army private named albert gitchell...
666
00:34:58,472 --> 00:35:00,597
He's a cook with the army...
667
00:35:00,641 --> 00:35:02,744
He reports symptoms,
so he goes to the hospital.
668
00:35:02,768 --> 00:35:05,018
Uh, he's sick,
he's-he's not feeling well.
669
00:35:05,104 --> 00:35:06,831
He's got a bit of a cough,
bit of a fever.
670
00:35:06,855 --> 00:35:09,606
In the end,
he ultimately goes in to work,
671
00:35:09,691 --> 00:35:13,110
feeding all of these
soldiers in this army camp.
672
00:35:13,153 --> 00:35:17,030
In the weeks that follow,
the members of this camp
673
00:35:17,116 --> 00:35:20,742
come down with a
pretty nasty flu strain.
674
00:35:20,786 --> 00:35:24,704
And there are no other outbreaks
similar to this at this point,
675
00:35:24,790 --> 00:35:28,500
which suggests that
this outbreak is starting
676
00:35:28,585 --> 00:35:31,086
at that camp,
and potentially with that soldier.
677
00:35:32,381 --> 00:35:36,967
There were 1,127
cases just at fort riley itself,
678
00:35:37,010 --> 00:35:38,635
and 46 people died.
679
00:35:38,679 --> 00:35:40,490
So all these soldiers
at fort riley are thinking
680
00:35:40,514 --> 00:35:43,807
they just had a bad cold,
or maybe even a mild flu.
681
00:35:43,892 --> 00:35:46,434
They were eventually
all put on trains,
682
00:35:46,478 --> 00:35:47,997
which spread all
over the country
683
00:35:48,021 --> 00:35:49,187
going to various ports.
684
00:35:49,273 --> 00:35:50,667
And then they were
all shipped off to europe
685
00:35:50,691 --> 00:35:52,315
to fight in the war.
686
00:35:52,401 --> 00:35:56,319
Many scientist now
believe that army private albert gitchell
687
00:35:56,405 --> 00:36:00,490
was the first man to
contract the 1918 flu.
688
00:36:00,534 --> 00:36:02,951
Gitchell spread it to
his fellow servicemen
689
00:36:03,036 --> 00:36:04,619
when he served them food.
690
00:36:04,705 --> 00:36:06,788
And soldiers then
were sent overseas
691
00:36:06,874 --> 00:36:09,958
to fight in the war,
and they unwittingly
692
00:36:10,002 --> 00:36:12,002
spread the disease
around the globe.
693
00:36:12,087 --> 00:36:15,797
But of course that
explanation is only a theory.
694
00:36:15,883 --> 00:36:20,302
The situation fits
the epidemiology,
695
00:36:20,387 --> 00:36:22,846
the number of people
who got sick afterwards.
696
00:36:22,890 --> 00:36:26,016
But whether we will
ever know for sure
697
00:36:26,101 --> 00:36:28,351
who patient zero was,
698
00:36:28,395 --> 00:36:31,062
or whether it absolutely
came from kansas,
699
00:36:31,148 --> 00:36:33,356
it's hard to be absolutely sure.
700
00:36:33,400 --> 00:36:36,026
It's really hard to learn
where any virus starts,
701
00:36:36,069 --> 00:36:39,821
where any pandemic starts,
because you're not recording
702
00:36:39,865 --> 00:36:41,865
everywhere all the time,
703
00:36:41,909 --> 00:36:43,491
and having the
scientific tools in place
704
00:36:43,535 --> 00:36:45,035
to be able to detect it.
705
00:36:47,122 --> 00:36:49,100
The great mystery
of any of these pandemics
706
00:36:49,124 --> 00:36:52,209
or public health crises
is where did it start?
707
00:36:52,252 --> 00:36:53,730
And, ultimately,
why did it start?
708
00:36:53,754 --> 00:36:57,005
And what were the circumstances
that allowed that to happen?
709
00:36:57,090 --> 00:36:59,883
It's the story of how we
interact with one another,
710
00:36:59,968 --> 00:37:02,844
and how we spread
diseases amongst each other.
711
00:37:02,930 --> 00:37:05,972
If you track that
and you find that out,
712
00:37:06,058 --> 00:37:09,226
we could prevent it
happening again in the future.
713
00:37:12,272 --> 00:37:15,815
The spanish flu
outbreak lasted for three long years
714
00:37:15,901 --> 00:37:19,653
and killed an estimated
50 million people
715
00:37:19,738 --> 00:37:24,157
before society finally developed
enough collective immunity
716
00:37:24,243 --> 00:37:26,952
for the virus to die out.
717
00:37:27,037 --> 00:37:30,914
History shows us that no matter
how lethal a disease may be,
718
00:37:30,958 --> 00:37:34,334
humankind has always
found a way to endure it,
719
00:37:34,419 --> 00:37:37,170
whether by employing
medical breakthroughs
720
00:37:37,256 --> 00:37:39,381
or sheer patience.
721
00:37:39,466 --> 00:37:42,801
But what kind of illnesses will
we have to face in the future?
722
00:37:42,886 --> 00:37:44,886
Could they be different than
723
00:37:44,930 --> 00:37:46,888
what we've
experienced in the past?
724
00:37:46,974 --> 00:37:51,559
And might they come to our
planet from another world?
725
00:37:59,444 --> 00:38:01,506
British
astronomer sir fred hoyle
726
00:38:01,530 --> 00:38:05,573
publishes a book titled
astronomical origins of life:
727
00:38:05,659 --> 00:38:08,785
Steps towards panspermia.
728
00:38:08,829 --> 00:38:11,496
In it,
hoyle investigates the controversial theory
729
00:38:11,581 --> 00:38:14,082
of panspermia,
which suggests that
730
00:38:14,167 --> 00:38:17,961
life on earth did
not originate here
731
00:38:18,005 --> 00:38:20,505
but rather in space,
732
00:38:20,590 --> 00:38:23,091
and that asteroids
carried the microbial
733
00:38:23,176 --> 00:38:25,969
building blocks of
dna to our planet.
734
00:38:29,141 --> 00:38:31,035
You cannot
dismiss the possibility
735
00:38:31,059 --> 00:38:33,727
that maybe life came
from outer space.
736
00:38:33,812 --> 00:38:37,647
That we were seeded.
Seeded by asteroids or comets
737
00:38:37,733 --> 00:38:40,066
that then put their
organic materials
738
00:38:40,152 --> 00:38:42,485
onto the planet earth.
739
00:38:42,529 --> 00:38:45,280
And so there's a new theory
in astronomy that says that
740
00:38:45,365 --> 00:38:47,532
the solar system is
like a ping-pong game
741
00:38:47,617 --> 00:38:50,702
with meteorites carrying
microbial lifeforms,
742
00:38:50,787 --> 00:38:53,747
going back and forth between venus,
mars,
743
00:38:53,832 --> 00:38:55,957
the earth and the moon.
744
00:38:56,043 --> 00:38:59,002
This has given momentum
to the panspermia theory.
745
00:39:00,339 --> 00:39:02,650
Some scientists
have suggested that if the theory
746
00:39:02,674 --> 00:39:04,341
of panspermia is true,
747
00:39:04,426 --> 00:39:08,762
then it's possible that
extraterrestrial viruses
748
00:39:08,847 --> 00:39:12,640
could also travel here,
bringing with them diseases
749
00:39:12,726 --> 00:39:14,392
that would be much different
750
00:39:14,478 --> 00:39:17,520
from the ones
that exist on earth.
751
00:39:17,606 --> 00:39:19,334
When you
think about the core elements
752
00:39:19,358 --> 00:39:22,484
of viral plagues... those
are the four genetic codes,
753
00:39:22,569 --> 00:39:25,195
dna or rna within
a protein shell...
754
00:39:25,280 --> 00:39:27,781
That's something that's
easier to imagine being stable
755
00:39:27,866 --> 00:39:29,532
deep inside an asteroid,
and safe.
756
00:39:29,618 --> 00:39:31,951
And so any sort
of virus or plague,
757
00:39:32,037 --> 00:39:33,953
you can imagine
them starting from
758
00:39:34,039 --> 00:39:36,623
one of these asteroid events.
759
00:39:36,708 --> 00:39:40,710
A space plague is a
leap into the unknown.
760
00:39:40,754 --> 00:39:43,713
We have no way of
knowing what kinds of dna,
761
00:39:43,799 --> 00:39:47,384
or maybe a modified dna
version exists in outer space.
762
00:39:48,678 --> 00:39:53,056
We have never seen other
kinds of viruses from outer space
763
00:39:53,100 --> 00:39:55,850
that can infect earthlings.
764
00:39:55,936 --> 00:39:58,186
So right now we simply
don't know the answer.
765
00:39:58,271 --> 00:40:01,439
I think if a plague
came from outer space,
766
00:40:01,525 --> 00:40:03,900
just like the way some
of the plagues we know
767
00:40:03,944 --> 00:40:06,403
jump from animals to humans,
suddenly,
768
00:40:06,446 --> 00:40:09,989
any sudden change in the viruses
769
00:40:10,075 --> 00:40:12,409
or bacteria that are
attacking you as a human,
770
00:40:12,494 --> 00:40:15,745
your immune system will not
have a defense to, most likely.
771
00:40:15,789 --> 00:40:17,934
These dramatic events,
whether it's from space
772
00:40:17,958 --> 00:40:20,333
or a sudden jumping
from animals to humans,
773
00:40:20,419 --> 00:40:23,336
are the reason these
plagues can be so devastating.
774
00:40:23,422 --> 00:40:26,923
A plague from outer space?
775
00:40:27,008 --> 00:40:29,217
While that may seem
like a far-fetched notion,
776
00:40:29,302 --> 00:40:34,055
it's a possibility that
science must be prepared for.
777
00:40:34,141 --> 00:40:36,422
There are always
these viruses out there,
778
00:40:36,476 --> 00:40:37,870
these things that
we can't explain.
779
00:40:37,894 --> 00:40:41,312
It's important for us to
always be vigilant, to be aware
780
00:40:41,398 --> 00:40:43,251
and to have our
public health authorities
781
00:40:43,275 --> 00:40:44,732
always on the lookout.
782
00:40:44,818 --> 00:40:46,129
So we can never
put our guard down.
783
00:40:46,153 --> 00:40:48,319
Hopefully, the faster we are
784
00:40:48,405 --> 00:40:50,613
and the better we
are at bioengineering,
785
00:40:50,699 --> 00:40:53,741
the faster we can make
vaccines and countermeasures.
786
00:40:53,827 --> 00:40:56,619
It's key to have them so
that we can make ways
787
00:40:56,705 --> 00:40:58,037
to protect ourselves.
788
00:40:58,123 --> 00:41:01,207
Preparing for any
disease is complex,
789
00:41:01,293 --> 00:41:06,254
and it requires a lot of, um,
mobilization of government,
790
00:41:06,339 --> 00:41:09,841
public health,
and the science to be able to figure out
791
00:41:09,926 --> 00:41:13,052
what happened,
and to prevent it from happening again.
792
00:41:13,138 --> 00:41:17,265
To be able to halt transmission
of this disease, whatever it is.
793
00:41:17,350 --> 00:41:20,351
It becomes a
detective story as well.
794
00:41:20,437 --> 00:41:23,354
You need to figure
out where it came from
795
00:41:23,440 --> 00:41:25,356
and how to
attribute the disease.
796
00:41:25,442 --> 00:41:29,194
It's a mystery that
our lives depend on,
797
00:41:29,279 --> 00:41:31,404
and we need people
to be working on that
798
00:41:31,490 --> 00:41:33,656
and thinking about that.
799
00:41:33,700 --> 00:41:37,660
Perhaps what makes
deadly diseases so frightening
800
00:41:37,704 --> 00:41:40,914
is that we never know when
they're going to strike next.
801
00:41:40,999 --> 00:41:44,334
And that uncertainty
is also what forces us
802
00:41:44,377 --> 00:41:48,296
to ask ourselves
are we really safe?
803
00:41:48,381 --> 00:41:52,217
Well,
the truth is that only time will tell.
804
00:41:52,302 --> 00:41:54,636
Which means that,
at least for now,
805
00:41:54,721 --> 00:41:59,265
these questions
will remain unexplained.
806
00:41:59,351 --> 00:42:02,185
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