1 00:02:53,967 --> 00:02:55,093 250, alright? 2 00:02:55,217 --> 00:02:56,545 250, yes please. 3 00:02:58,096 --> 00:02:59,848 Then aim for 350. 4 00:03:03,592 --> 00:03:05,193 Heparin injection please. 5 00:03:08,476 --> 00:03:09,771 There's a bit of bleeding there. 6 00:03:12,779 --> 00:03:14,342 Start ECC bypass. 7 00:03:14,560 --> 00:03:15,787 OK, ECC bypass. 8 00:03:16,998 --> 00:03:19,724 - Say cheese! - Stop acting the goat for once! 9 00:03:21,204 --> 00:03:22,489 Good... are we ready? 10 00:03:23,022 --> 00:03:24,788 - Ready for cardioplegia? - Yes. 11 00:03:24,952 --> 00:03:26,842 - Go ahead. - Starting. 12 00:03:27,417 --> 00:03:29,294 Here are the syringes, Jean-Yves. 13 00:03:29,608 --> 00:03:31,212 - 500. - 500, right. 14 00:03:32,630 --> 00:03:33,717 Aorta clamp. 15 00:03:35,198 --> 00:03:36,100 Fix it. 16 00:03:36,900 --> 00:03:37,942 Done. 17 00:03:38,261 --> 00:03:39,241 Cardioplegia. 18 00:03:39,436 --> 00:03:41,100 OK... heart to stop. 19 00:03:43,057 --> 00:03:43,975 Heart stopped. 20 00:03:44,183 --> 00:03:46,644 - Fine. - See Irene, the heart is stopping. 21 00:03:46,853 --> 00:03:48,980 Gently... gently... 22 00:03:49,272 --> 00:03:51,116 It'll take a few more seconds. 23 00:03:55,987 --> 00:03:57,405 I'm at 150. 24 00:03:58,531 --> 00:03:59,574 Clamp. 25 00:04:07,206 --> 00:04:10,116 - OK, it's clamped. - Stopped completely? 26 00:04:10,710 --> 00:04:11,961 Yes, it's good. 27 00:04:12,170 --> 00:04:13,129 It's good. 28 00:04:16,966 --> 00:04:18,334 Lean over here, Irene. 29 00:04:24,655 --> 00:04:25,533 Look. 30 00:04:25,592 --> 00:04:29,103 The heart valve and the sub-valvular device have thickened. 31 00:04:31,648 --> 00:04:33,274 I need to replace it. 32 00:04:35,068 --> 00:04:36,805 Sandrine, put it on here. 33 00:04:44,484 --> 00:04:45,461 Stitch. 34 00:04:46,120 --> 00:04:48,206 Very good... hand-stitch it. 35 00:04:49,791 --> 00:04:51,125 Stitch the valve. 36 00:04:55,296 --> 00:04:57,423 - This bit to pathology? - Yes. 37 00:05:01,664 --> 00:05:03,513 Goodbye... thanks very much. 38 00:05:03,721 --> 00:05:05,828 Goodbye, Irene. 39 00:05:06,437 --> 00:05:08,234 It looks like rheumatism. 40 00:05:08,935 --> 00:05:10,144 That's what she thinks. 41 00:05:29,156 --> 00:05:30,578 You can see it clearly here. 42 00:05:31,374 --> 00:05:33,008 It's not closing as it should. 43 00:05:38,945 --> 00:05:41,050 And there it's leaking heavily. 44 00:05:41,320 --> 00:05:42,301 See that? 45 00:05:45,414 --> 00:05:49,453 It is similar to what the Americans have described when using Isomeride. 46 00:05:49,883 --> 00:05:50,930 Looks the same. 47 00:05:51,060 --> 00:05:52,979 The name of the drug is different. 48 00:05:54,105 --> 00:05:56,232 Show me that before treatment. 49 00:05:56,816 --> 00:06:00,456 I have her endocrinological report from 2005. 50 00:06:04,589 --> 00:06:06,456 Doesn't this seem normal? 51 00:06:06,908 --> 00:06:09,245 Completely... It's going like this. 52 00:06:12,972 --> 00:06:14,323 Looks at this now. 53 00:06:17,253 --> 00:06:19,815 You see the blood flowing in, but there's no leak. 54 00:06:27,096 --> 00:06:28,878 She's taken in it late 2006. 55 00:06:30,956 --> 00:06:33,628 That makes 11 cases... and this one's iron-clad. 56 00:06:34,562 --> 00:06:35,972 It's time to act. 57 00:08:16,634 --> 00:08:20,987 French Health Products Safety Agency 58 00:08:23,479 --> 00:08:28,518 We have a large number of cases for a medium-size university hospital. 59 00:08:29,385 --> 00:08:35,401 In the light of these worrying clinical and pharmacological factors... 60 00:08:36,330 --> 00:08:41,404 ...we should consider the question of withdrawing 'Mediator' from the market. 61 00:08:41,682 --> 00:08:45,237 You can't recall a drug that's been approved, just like that! 62 00:08:46,174 --> 00:08:48,815 There is a toxicity that is deeply disturbing. 63 00:08:49,280 --> 00:08:51,949 This medication is used extensively. It should… 64 00:08:52,158 --> 00:08:55,963 Madame, we cannot take personal opinions into account. 65 00:08:56,198 --> 00:08:59,040 Thank you, but we shall discuss this between ourselves... 66 00:08:59,549 --> 00:09:03,041 ...and move on to the next matter, one that is of major concern. 67 00:09:03,294 --> 00:09:05,213 The swine-flu epidemic. 68 00:09:07,001 --> 00:09:11,820 Please take a copy of the latest report from the Ministry of Health. 69 00:09:13,609 --> 00:09:18,320 Another presentation is to be given in the adjoining room. 70 00:09:20,398 --> 00:09:25,171 It is recommended that we consider a comprehensive Tamiflu vaccination... 71 00:09:44,043 --> 00:09:45,336 Catherine Haynes. 72 00:09:45,544 --> 00:09:46,367 Hello. 73 00:09:46,484 --> 00:09:47,914 Do you have 5 minutes? 74 00:09:48,008 --> 00:09:49,820 - Yes. Coffee? - No. 75 00:09:50,406 --> 00:09:53,734 An inquiry is in progress. I slipped out for a minute. 76 00:09:53,969 --> 00:09:55,266 Is it always like that? 77 00:09:55,805 --> 00:09:57,688 It was like talking to a brick wall. 78 00:09:57,797 --> 00:10:00,559 Your presentation was excellent. 79 00:10:01,102 --> 00:10:03,844 Especially when the symptoms are very specific. 80 00:10:06,148 --> 00:10:09,860 I will bring the matter to the Medical Safety Council. 81 00:10:10,069 --> 00:10:13,141 They're not ones to judge on superficialities. 82 00:10:13,281 --> 00:10:14,875 They're the real experts experts. 83 00:10:19,594 --> 00:10:21,336 We'll stay in touch by e-mail. 84 00:10:23,328 --> 00:10:26,336 Continue with your research. I'll be pushing from my side. 85 00:10:40,125 --> 00:10:42,656 You have to get straight to the point. 86 00:10:42,790 --> 00:10:44,539 It's best. Otherwise you'll wait for ages. 87 00:10:44,781 --> 00:10:45,969 You know Bihan? 88 00:10:46,981 --> 00:10:48,816 Passed him in the corridor. 89 00:10:48,984 --> 00:10:50,641 Do not act too friendly. 90 00:10:51,569 --> 00:10:54,905 - I won't embarrass you, boss. - These guys are the heavyweights. 91 00:10:57,783 --> 00:10:59,577 'Isomeride'. 'Mediator.' 92 00:10:59,785 --> 00:11:01,662 Same molecule... Norfenfluramine. 93 00:11:01,922 --> 00:11:03,914 Not mentioned on the label. 94 00:11:06,625 --> 00:11:09,656 This is a heart valve that has been exposed to 'Mediator'. 95 00:11:10,267 --> 00:11:11,727 The effect is clear. 96 00:11:25,436 --> 00:11:27,146 What does AFSSAPS say? 97 00:11:27,355 --> 00:11:29,867 No reaction. As if brain-dead. 98 00:11:30,422 --> 00:11:33,297 It's a Breton case, Breton doctors... 99 00:11:33,438 --> 00:11:36,155 Brest Uni Hospital… Nothing to interest them. 100 00:11:36,822 --> 00:11:40,467 Except for the epidemiologist at the Gustave Roussy Institute… 101 00:11:40,868 --> 00:11:42,787 Who? Catherine Haynes? 102 00:11:42,881 --> 00:11:43,788 Yes. 103 00:11:44,413 --> 00:11:45,850 You know her? 104 00:11:45,912 --> 00:11:48,084 I did her course at uni. 105 00:11:48,292 --> 00:11:49,529 Impressive lady?! 106 00:11:50,044 --> 00:11:53,217 Apparently she's some sort of rock-star in her field. 107 00:11:53,428 --> 00:11:55,607 You could say that, yes. 108 00:11:55,803 --> 00:12:00,618 When she said that she agreed they were a serious indication, I was very pleased. 109 00:12:01,412 --> 00:12:04,642 I'd been looking at so many heart valves… 110 00:12:05,037 --> 00:12:06,436 ...I felt I was going nuts. 111 00:12:09,146 --> 00:12:10,545 So... 112 00:12:11,045 --> 00:12:12,279 Sir... 113 00:12:14,819 --> 00:12:16,357 What did Catherine recommend? 114 00:12:16,498 --> 00:12:18,537 To do a study... and quickly. 115 00:12:18,842 --> 00:12:22,717 It seems experts fear Big Pharma more than toxic side effects. 116 00:12:23,061 --> 00:12:27,553 To get them to move, you have to stick a maxi-firecracker up their arses. 117 00:12:34,004 --> 00:12:35,423 The problem... 118 00:12:35,998 --> 00:12:39,826 ...is that I'm not a scientist and I don't have the money to pay to have it done. 119 00:12:40,311 --> 00:12:42,295 I'm not good enough to do it myself. 120 00:12:43,029 --> 00:12:45,678 I need the backup of some real professionals. 121 00:12:54,233 --> 00:12:58,404 If a patient of mine had this valve I would have come across it. 122 00:12:58,612 --> 00:13:00,406 And I'm sure we shall. 123 00:13:00,756 --> 00:13:03,544 However, in order to get the right numbers... 124 00:13:03,569 --> 00:13:08,013 ...you need two case-control patients for each case, or even three. 125 00:13:08,139 --> 00:13:13,795 We can easily find plenty of the same age, sex and hospitalisation. 126 00:13:14,318 --> 00:13:16,721 This would enable us to make the strongest case. 127 00:13:16,922 --> 00:13:20,490 But we can't do it with case-control patients who have healthy heart valves. 128 00:13:20,702 --> 00:13:22,553 I know there'll be some problems... 129 00:13:23,154 --> 00:13:24,693 but I believe it can work. 130 00:13:24,972 --> 00:13:28,115 And patients with an aortic valve condition are easy to come by. 131 00:13:28,559 --> 00:13:31,228 A simple procedure that will spit out a quick result. 132 00:13:32,053 --> 00:13:35,420 Is there any reason not to bring in other hospitals? 133 00:13:35,693 --> 00:13:36,521 Yes? 134 00:13:37,443 --> 00:13:40,170 - I'd say we've not the time. - Not the time? 135 00:13:40,725 --> 00:13:44,450 This drug's been around for 30 years. That's nonsense. 136 00:13:44,634 --> 00:13:48,006 We could say... "Starting tomorrow, we'll see what happens" 137 00:13:49,622 --> 00:13:51,264 But that'd take forever. 138 00:13:53,686 --> 00:13:55,123 What do you think, David? 139 00:13:56,921 --> 00:14:01,482 A case-control study can still be a bit of a trap. 140 00:14:02,178 --> 00:14:04,720 - It can be a poor-man's solution. - Or an urgent one. 141 00:14:04,929 --> 00:14:08,217 Seeing the pharma we're up against... it's better to avoid approximations. 142 00:14:09,295 --> 00:14:11,101 That being said... 143 00:14:11,560 --> 00:14:15,424 It'd be was like when diethylstilbestrol was recalled in the US in 1974 144 00:14:16,065 --> 00:14:17,409 A small case-control study. 145 00:14:17,530 --> 00:14:18,955 Let's not get jumpy! 146 00:14:19,416 --> 00:14:23,674 It's just a company like any other with a few skeletons in the closet. 147 00:14:24,281 --> 00:14:25,854 It's not Darth Vader. 148 00:14:26,283 --> 00:14:27,993 And after Isomeride... 149 00:14:28,202 --> 00:14:31,620 ...if they don't want a second scandal, they won't bring it back. 150 00:14:41,549 --> 00:14:42,424 Patoche... 151 00:14:42,633 --> 00:14:45,907 ...get out all the cardio-valve case-files we have here, and sort them… 152 00:14:45,932 --> 00:14:48,940 …between "known causes" and "likely cause unknown". 153 00:14:56,855 --> 00:14:59,073 Are you going to do all this in overtime? 154 00:15:00,276 --> 00:15:03,120 I don't have a husband complaining at home. 155 00:15:03,605 --> 00:15:06,699 The kids are with him, so I have some free time. 156 00:15:07,449 --> 00:15:09,743 - But we can be "Tu" can't we? - Oh, sure. 157 00:16:02,171 --> 00:16:03,130 Fine. 158 00:16:03,644 --> 00:16:07,009 Still a bit of a whistle. And your new valve is noisy. 159 00:16:07,331 --> 00:16:10,220 I sleep with the TV on so I don't hear it. 160 00:16:10,429 --> 00:16:12,362 And I have bronchitis again. 161 00:16:12,480 --> 00:16:13,886 I noticed that. 162 00:16:14,016 --> 00:16:17,561 I'm going to up your treatment with a budesonide inhaler. 163 00:16:18,479 --> 00:16:20,773 - That's cortisone, isn't it? - Yes. 164 00:16:22,149 --> 00:16:23,609 Why, is it a problem? 165 00:16:23,909 --> 00:16:26,654 - It'll make me even fatter. - Oh no! 166 00:16:27,029 --> 00:16:28,656 It's a cortisone inhaler. 167 00:16:28,989 --> 00:16:32,565 In that form, it can't make you any bigger. 168 00:16:32,868 --> 00:16:35,829 I'm putting on weight anyway. I went up 7 kilos this month. 169 00:16:36,288 --> 00:16:40,167 Since the operation, I've been too tired to ever move. 170 00:16:40,815 --> 00:16:43,879 And controlling your appetite is not easy. 171 00:16:45,422 --> 00:16:49,269 My Mediator prescription is out, which is a shame, as it helped. 172 00:16:49,519 --> 00:16:50,440 No... 173 00:16:51,011 --> 00:16:53,055 It never helped anyone. 174 00:16:53,263 --> 00:16:55,891 It may be the cause of your heart trouble. 175 00:16:56,341 --> 00:16:57,175 No... 176 00:16:57,870 --> 00:17:01,644 I've always been OK with it. I've never had any worries. 177 00:17:01,815 --> 00:17:03,607 Madame Zacharria, I assure you. 178 00:17:04,191 --> 00:17:05,104 It is… 179 00:17:05,416 --> 00:17:06,667 ...not recommended. 180 00:17:07,528 --> 00:17:09,196 Out with Mediator. 181 00:17:09,697 --> 00:17:11,073 Feed it to the rats. 182 00:17:12,080 --> 00:17:14,776 You've already taken Mediator? 183 00:17:15,244 --> 00:17:17,346 By tablet or with insulin? 184 00:17:18,276 --> 00:17:20,416 Why did you have it prescribed? 185 00:17:24,962 --> 00:17:27,840 Could a doctor or pharmacist confirm that to us? 186 00:17:28,048 --> 00:17:29,425 Cholesterol problem. 187 00:17:29,633 --> 00:17:32,237 I'm reviving your pain with my call? I'm very sorry. 188 00:17:32,344 --> 00:17:33,784 Insulin treatment? 189 00:17:35,222 --> 00:17:36,598 How many capsules? 190 00:17:43,856 --> 00:17:47,541 Hello, I'm calling from the hospital. May I speak with your mother? 191 00:18:17,097 --> 00:18:21,351 She is still feeling weak, and with respiratory problems. 192 00:18:21,560 --> 00:18:24,271 I'm booking outpatient care... 193 00:18:26,523 --> 00:18:31,028 ...for the immediate future, before sending her to Guervenan. 194 00:18:52,466 --> 00:18:55,511 If I could have just a moment... I have a patient... 195 00:18:55,916 --> 00:18:59,389 Catherine says her pressure tactics have borne fruit. 196 00:18:59,838 --> 00:19:04,057 The Medical Safety Council is going to see me. 197 00:19:04,561 --> 00:19:05,354 When? 198 00:19:06,688 --> 00:19:08,104 Next Tuesday at AFSSAPS. 199 00:19:08,357 --> 00:19:09,955 - That's no good. - Why? 200 00:19:10,588 --> 00:19:11,610 It's too soon. 201 00:19:13,760 --> 00:19:16,557 - I beeped you. Don't you reply? - You beeped me? 202 00:19:18,901 --> 00:19:21,829 No technicians are available. Everything's at a standstill. 203 00:19:22,284 --> 00:19:24,541 This little case-control study has created havoc. 204 00:19:24,635 --> 00:19:25,384 Hello! 205 00:19:25,409 --> 00:19:27,790 I have the boss's authorisation for this study. 206 00:19:28,150 --> 00:19:29,728 I committed myself... we're almost there. 207 00:19:29,799 --> 00:19:31,171 Do I have to spell it out? 208 00:19:31,643 --> 00:19:34,245 We're a team here... stop fooling around. 209 00:19:35,520 --> 00:19:39,857 Do you think a small outfit like ours have the means to upset the balance? 210 00:19:40,518 --> 00:19:42,330 War on Big Bad Pharma? Is that it? 211 00:19:43,065 --> 00:19:46,186 You'll never make it, and it'll cost you dearly. 212 00:19:46,963 --> 00:19:49,268 Without their financing, no research is possible. 213 00:19:52,359 --> 00:19:55,057 In our case, it's not partnership. 214 00:19:55,799 --> 00:19:59,065 It's compromise. There is a difference. 215 00:19:59,199 --> 00:20:00,526 She's right. 216 00:20:00,951 --> 00:20:03,315 I'm doing this to benefit patients? 217 00:20:03,440 --> 00:20:05,620 She has nothing to lose. You have everything. 218 00:20:05,956 --> 00:20:07,760 You'll just make a fool of yourself. 219 00:20:08,596 --> 00:20:12,205 When we've nothing left, you can join the alter-globalisationists. 220 00:20:12,354 --> 00:20:14,089 You can destroy yourself, but leave us out of it . 221 00:20:14,298 --> 00:20:17,018 - And reply when I beep you! - Thanks for the support. 222 00:20:17,065 --> 00:20:18,176 Good conversation. 223 00:20:18,385 --> 00:20:20,752 - Very constructive. - You want the truth or my support? 224 00:20:21,580 --> 00:20:23,518 I'm no alter-globalisationist. 225 00:20:23,543 --> 00:20:26,205 I also work with pharma companies. 226 00:20:26,323 --> 00:20:28,393 And I believe in therapeutic innovation. 227 00:20:28,812 --> 00:20:30,330 - It's Tuesday, isn't it? - What? 228 00:20:30,416 --> 00:20:32,691 - Your meeting with AFSSAPS. - Yes. 229 00:20:36,745 --> 00:20:39,229 Don't say anything about the case studies. 230 00:20:39,393 --> 00:20:40,073 Why? 231 00:20:40,449 --> 00:20:42,659 Never leak a study before it's completed. 232 00:20:42,784 --> 00:20:46,096 So what more do I have to talk about? 233 00:20:46,663 --> 00:20:48,205 I regret that it's premature. 234 00:20:57,925 --> 00:21:00,448 Good, I'll play the flute... 235 00:21:01,159 --> 00:21:02,580 ...a Danish flute. 236 00:21:02,721 --> 00:21:05,752 Good morning, I'm a medical researcher from Brest... 237 00:21:10,502 --> 00:21:13,899 Do you have Mediator as a medication? 238 00:21:47,641 --> 00:21:51,995 Mr Aubert, Director of Drug Safety for Servier Laboratories. 239 00:21:54,022 --> 00:21:59,971 Two easily verifiable facts could have alleviated your fears, Dr Frachon... 240 00:22:00,362 --> 00:22:04,651 ...and saved you the long trip from Brest. 241 00:22:05,659 --> 00:22:09,346 The first is that our product, Mediator, 242 00:22:09,565 --> 00:22:12,769 ...treats diabetes in more than 2 million French people. 243 00:22:13,291 --> 00:22:16,261 With very satisfying results. 244 00:22:16,449 --> 00:22:19,425 The second is, that in 30 years on the market... 245 00:22:19,519 --> 00:22:23,957 ...it has never been associated with any cardiovascular effects. 246 00:22:24,136 --> 00:22:30,425 Assessing such a risk, just based on a local survey, seems unwise. 247 00:22:30,767 --> 00:22:33,645 In our eyes, these are just simple coincidences. 248 00:22:33,925 --> 00:22:36,565 Why not a Breton gene? 249 00:22:37,399 --> 00:22:42,529 In regards to those patient-types that you have identified... 250 00:22:43,042 --> 00:22:46,285 ...obese, diabetic, elderly... 251 00:22:46,575 --> 00:22:51,079 Heart-valve problems are a frequent, even common occurrence. 252 00:22:51,800 --> 00:22:54,433 With natural causes, in multiple-disease cases. 253 00:22:54,636 --> 00:22:59,722 Imputing this pathology to our medication, proves a lack of knowledge of the question. 254 00:23:00,464 --> 00:23:01,949 This is not a criticism. 255 00:23:02,114 --> 00:23:05,050 You are a lung-, not a heart-specialist. 256 00:23:05,260 --> 00:23:08,847 But in this case you could also incriminate aspirin. 257 00:23:09,191 --> 00:23:10,390 You understand? 258 00:23:13,852 --> 00:23:16,980 I am neither a researcher nor a cardiologist, that's true... 259 00:23:17,574 --> 00:23:21,574 But I spent my last year of internship in a pneumology department... 260 00:23:21,628 --> 00:23:26,907 ...where I saw young women die after exposure to another of your drugs... 261 00:23:27,115 --> 00:23:28,158 Isomeride. 262 00:23:31,203 --> 00:23:32,537 There were… 263 00:23:33,038 --> 00:23:35,332 ...many young mothers... 264 00:23:35,832 --> 00:23:37,136 ...girls of my age... 265 00:23:37,584 --> 00:23:39,628 ...who'd taken it because… 266 00:23:42,130 --> 00:23:43,965 ...they felt a bit... 267 00:23:44,800 --> 00:23:47,511 ...ugly after pregnancy, they wanted... 268 00:23:47,816 --> 00:23:49,429 ...to get their figure back. 269 00:23:52,307 --> 00:23:55,102 I can still see the faces of every single one of them. 270 00:23:56,686 --> 00:23:58,378 Young women who died... 271 00:23:59,189 --> 00:24:00,996 ...a dreadful death. 272 00:24:01,355 --> 00:24:04,505 Without redress, without justice, without anything! 273 00:24:04,917 --> 00:24:07,855 Killed by that filthy norfenfluramine! 274 00:24:13,161 --> 00:24:14,371 Unfortunately, madam... 275 00:24:14,824 --> 00:24:16,665 ...as you would surely know... 276 00:24:16,873 --> 00:24:19,886 ...no drug is perfectly safe. 277 00:24:20,460 --> 00:24:23,171 We have to examine the risk-benefit balance. 278 00:24:23,380 --> 00:24:25,300 The risk-benefit balance? 279 00:24:25,613 --> 00:24:27,590 We are talking about an appetite suppressant. 280 00:24:27,777 --> 00:24:29,018 Not a cancer treatment. 281 00:24:29,113 --> 00:24:33,808 Morbid obesity, madam, is one of the great plagues of our western society. 282 00:24:34,683 --> 00:24:38,050 Denial doesn't protect patients from risk, as far as a I'm aware. 283 00:24:39,610 --> 00:24:40,569 Denial? 284 00:24:41,106 --> 00:24:42,558 Yes, denial! 285 00:24:42,964 --> 00:24:46,278 That of the anorectic properties of your molecule, for example... 286 00:24:46,486 --> 00:24:48,707 ...not mentioned on the label. 287 00:24:48,917 --> 00:24:54,183 Or Norfenfluramine which enters the body at a concentration rate... 288 00:24:54,411 --> 00:24:56,621 ...near that of Isomeride. 289 00:25:00,417 --> 00:25:03,816 Madam, your allegations leave me speechless. 290 00:25:04,074 --> 00:25:07,299 The labeling of our products is in total compliance. 291 00:25:07,457 --> 00:25:11,453 If there had been anything harmful about Mediator in the 30 years... 292 00:25:11,633 --> 00:25:14,890 ...of doctors prescribing it, and it being reimbursed… 293 00:25:15,156 --> 00:25:16,953 ...we would have known about it. 294 00:25:17,017 --> 00:25:19,859 In addition, we would like to know... 295 00:25:20,812 --> 00:25:26,016 …what evidence... on what evidence do you base... 296 00:25:26,680 --> 00:25:29,109 ...this unreasonable obstinacy? 297 00:25:40,874 --> 00:25:44,305 The case-control study that started in Brest, first of all. 298 00:25:44,484 --> 00:25:47,422 ...which should soon confirm a very strong trend. 299 00:25:49,341 --> 00:25:50,800 A case-control study? 300 00:25:51,009 --> 00:25:51,635 Really? 301 00:25:53,762 --> 00:25:56,411 Do not take me amiss, Mrs Frachon, but... 302 00:25:56,806 --> 00:26:01,227 ...do you have a competent epidemiological research Centre in Brest? 303 00:26:02,103 --> 00:26:03,146 Yes. 304 00:26:03,598 --> 00:26:05,684 The Centre for Clinical Research. 305 00:26:06,274 --> 00:26:09,411 I asked Professor Le Bihan's team for help. 306 00:26:13,657 --> 00:26:16,184 Professor Le Bihan? 307 00:26:17,559 --> 00:26:19,981 To sum up...The Breton "Dream Team"! 308 00:26:24,325 --> 00:26:28,247 Well then. Since we are now talking about Mediator studies... 309 00:26:28,567 --> 00:26:31,317 So what about "Regulate"... 310 00:26:31,395 --> 00:26:34,469 ...the international clinical study, begun in… 311 00:26:35,512 --> 00:26:37,926 In 2000... That's 9 years ago. 312 00:26:39,130 --> 00:26:42,231 The preliminary results are being validated. 313 00:26:42,488 --> 00:26:47,985 But definite results could take another year or two, or so. 314 00:26:48,868 --> 00:26:52,727 Real research, when done in a rigorous way... 315 00:26:53,238 --> 00:26:55,626 ...always takes a bit longer. 316 00:26:55,740 --> 00:26:56,977 Don't take too long. 317 00:26:57,063 --> 00:26:59,251 We always do our best, Sir. 318 00:26:59,345 --> 00:27:00,134 Good. 319 00:27:00,337 --> 00:27:02,163 Now we'll take a vote. 320 00:27:02,372 --> 00:27:04,749 Thank you gentlemen... madam. 321 00:27:08,235 --> 00:27:09,876 Stay there, madam. 322 00:27:19,472 --> 00:27:21,391 To the question, are you in favour... 323 00:27:21,497 --> 00:27:25,626 ...of waiting for the results of current or planned studies, namely... 324 00:27:25,821 --> 00:27:27,939 ...those of Servier Laboratories... 325 00:27:28,606 --> 00:27:31,735 ...and of CIC-Brest, before any proposed action? 326 00:27:31,915 --> 00:27:33,445 You can't wait! 327 00:27:33,653 --> 00:27:34,735 People are dying. 328 00:27:34,782 --> 00:27:37,139 Of the 11 cases presented, one is already dead.. 329 00:27:37,259 --> 00:27:39,852 Madam, if you please... the debate has been concluded. 330 00:27:41,065 --> 00:27:41,985 Those for... 331 00:27:42,829 --> 00:27:45,712 Raise your hands so you can be counted. 332 00:27:47,000 --> 00:27:47,959 Sixteen. 333 00:27:48,168 --> 00:27:49,169 Thank you. 334 00:27:49,377 --> 00:27:50,962 Those against? 335 00:27:51,921 --> 00:27:52,756 Two. 336 00:27:53,089 --> 00:27:54,446 Abstaining? 337 00:27:55,508 --> 00:27:57,010 - Five. - Very good. 338 00:28:05,544 --> 00:28:07,485 You've shot yourself in the foot. 339 00:28:11,316 --> 00:28:13,688 I haven't given away any figures or results. 340 00:28:13,860 --> 00:28:17,212 No study has any significance without publication. 341 00:28:19,115 --> 00:28:21,284 But Antoine is on it. 342 00:28:21,563 --> 00:28:26,555 What if they can impound the data, before you're able to have it published? 343 00:28:28,750 --> 00:28:30,502 Which is not a certainty, anyway. 344 00:28:32,003 --> 00:28:33,671 They have the right to do that? 345 00:28:33,880 --> 00:28:35,751 AFSSAPS represents the state. 346 00:28:36,243 --> 00:28:39,260 If it wants something to fulfill its purpose... 347 00:28:39,469 --> 00:28:42,337 ...it can pull out all the stops to get it. 348 00:28:43,313 --> 00:28:47,192 And major publications hate stale results. Ask Antoine. 349 00:28:47,394 --> 00:28:49,774 They only want exclusives. 350 00:28:53,313 --> 00:28:57,524 It's obvious that you have to complete your article in record time. 351 00:29:33,773 --> 00:29:34,774 We ready? 352 00:29:57,745 --> 00:29:58,746 It's coming up. 353 00:30:04,565 --> 00:30:05,774 70 per cent. 354 00:30:06,556 --> 00:30:07,916 Fucking hell! 355 00:30:13,160 --> 00:30:14,471 She was right. 356 00:30:22,619 --> 00:30:27,244 You mean this shit is responsible for 70 per cent of valve problems of this type? 357 00:30:27,653 --> 00:30:28,810 It's totally insane! 358 00:30:30,517 --> 00:30:31,775 Well, guys... 359 00:30:31,954 --> 00:30:33,291 We hit the jackpot. 360 00:30:33,500 --> 00:30:35,103 Now it's official 361 00:30:35,533 --> 00:30:37,853 French cardios have been blind for 30 years. 362 00:30:39,923 --> 00:30:41,674 You don't always find only what you're looking for. 363 00:30:42,298 --> 00:30:43,736 Nobody's going to accept it. 364 00:30:43,978 --> 00:30:46,244 They'll say "banana republic election results". 365 00:30:46,368 --> 00:30:49,032 With a surprising result, you have to ask yourself... 366 00:30:49,111 --> 00:30:50,845 "What if it IS true?" 367 00:30:53,603 --> 00:30:55,713 Are statistics easily doctored? 368 00:30:55,971 --> 00:30:57,455 Are you kidding?! 369 00:30:57,524 --> 00:30:59,025 What now? 370 00:30:59,234 --> 00:31:02,408 Calm down, nobody's doctored any stats. 371 00:31:04,489 --> 00:31:07,283 Well, the article... When can we have it? 372 00:31:07,742 --> 00:31:08,791 Tomorrow? 373 00:31:09,354 --> 00:31:10,328 You're joking? 374 00:31:10,828 --> 00:31:11,871 No. 375 00:31:13,081 --> 00:31:15,987 You know me... Patience is not my thing. 376 00:31:41,682 --> 00:31:42,737 Shit! 377 00:31:52,453 --> 00:31:53,329 Two minutes ! 378 00:32:08,268 --> 00:32:10,205 Wow! You're a Rolls Royce! 379 00:32:10,791 --> 00:32:12,890 I write English, but speaking… 380 00:32:13,099 --> 00:32:14,174 Let me hear you. 381 00:32:17,893 --> 00:32:20,721 "Exposure to fenfluramine and dexfenfluramine has been 382 00:32:20,924 --> 00:32:24,299 "associated with the occurrence of cardiovascular side effects…" 383 00:32:24,440 --> 00:32:26,143 Get a load of the bodywork! 384 00:32:38,333 --> 00:32:40,877 Molene is there and Ouessant on the right side. 385 00:32:41,135 --> 00:32:42,462 That's Ouessant there! 386 00:32:43,119 --> 00:32:45,673 You're not going to teach me my islands! 387 00:32:46,758 --> 00:32:48,416 Stop with that shit! 388 00:32:48,690 --> 00:32:50,018 You're a pain in the arse! 389 00:32:51,929 --> 00:32:53,885 I can't even share it with you. 390 00:32:54,349 --> 00:32:55,932 Want to share something with me? 391 00:32:56,026 --> 00:32:58,799 - Yeah, something cool for a change. - Something cool? 392 00:32:58,916 --> 00:32:59,729 Yeah. 393 00:33:00,438 --> 00:33:01,689 Something cool… 394 00:33:02,838 --> 00:33:04,362 Here you are, sweetie-pie! 395 00:33:17,121 --> 00:33:18,081 Well... 396 00:33:19,118 --> 00:33:20,518 Well, back to work? 397 00:34:08,631 --> 00:34:09,799 Good morning. 398 00:34:42,498 --> 00:34:43,791 Hi, Irene. 399 00:34:44,000 --> 00:34:45,096 Hi, Sylvie. 400 00:34:45,626 --> 00:34:48,440 Now, Mr Grall, take a deep breath! 401 00:34:49,088 --> 00:34:51,182 Both lungs, that's right. 402 00:34:52,967 --> 00:34:54,237 Deep breath. 403 00:34:59,390 --> 00:35:01,726 Very good... you can sit down again. 404 00:35:05,396 --> 00:35:08,316 Well, your lungs are in great shape. 405 00:35:08,479 --> 00:35:09,987 So why do I need glasses? 406 00:35:10,784 --> 00:35:12,776 This isn't the optometrist, Dad. 407 00:35:12,893 --> 00:35:15,862 I'm Dr Frachon, the lung specialist. 408 00:35:16,424 --> 00:35:18,338 We've met before. 409 00:35:19,202 --> 00:35:20,328 Irene ? 410 00:35:20,536 --> 00:35:22,079 Yes, Irene. 411 00:35:22,497 --> 00:35:24,582 I get so confused. 412 00:35:27,557 --> 00:35:28,669 Behave yourself! 413 00:35:29,420 --> 00:35:31,987 I have a husband who doesn't get jealous. 414 00:35:32,041 --> 00:35:32,924 So much the better! 415 00:35:34,026 --> 00:35:35,557 Would you like a chocolate? 416 00:35:35,674 --> 00:35:37,970 417 00:35:38,179 --> 00:35:39,936 August 2009 418 00:35:43,436 --> 00:35:45,269 We said no phone for 2 hours. 419 00:35:45,478 --> 00:35:47,688 - Yes, but it's Antoine. - Doesn't matter! 420 00:35:48,147 --> 00:35:50,428 OK, if it means saving the world. 421 00:35:50,662 --> 00:35:52,527 No, this is the one I want. 422 00:35:53,069 --> 00:35:56,803 But I also want to find one that I choose for you. 423 00:35:57,240 --> 00:36:00,076 Here we are... "A Woman's Guide to Men". 424 00:36:00,131 --> 00:36:01,342 Whatever. 425 00:36:01,475 --> 00:36:03,830 Stop it, you sex maniac. 426 00:36:09,669 --> 00:36:11,254 Antoine, I'm with the kids. 427 00:36:11,462 --> 00:36:13,005 It's Amelie's birthday. 428 00:36:13,491 --> 00:36:15,132 Can I call you back? 429 00:36:15,522 --> 00:36:17,176 They know about our case-control study. 430 00:36:17,969 --> 00:36:19,905 How did that get out? 431 00:36:22,265 --> 00:36:25,116 They didn't care about anything put to them. 432 00:36:25,366 --> 00:36:28,609 They treated me like some hillbilly bitch. 433 00:36:29,046 --> 00:36:30,062 I had no choice. 434 00:36:30,414 --> 00:36:32,859 Are you sure? Or was your pride pricked? 435 00:36:33,067 --> 00:36:34,777 Let's not argue now. 436 00:36:34,986 --> 00:36:37,812 We put the article together in record time. 437 00:36:37,953 --> 00:36:40,157 - For good reason. - Isn't that what counts?! 438 00:36:40,492 --> 00:36:42,812 Save your energy for the next round. 439 00:36:42,910 --> 00:36:44,297 You'll be served. 440 00:36:44,745 --> 00:36:48,055 We've been summoned by the public health authority... 441 00:36:48,080 --> 00:36:50,817 ...to present our results by the 29th of September. 442 00:36:54,117 --> 00:36:55,256 That's how you knew? 443 00:36:55,367 --> 00:36:56,437 Yes, that's right. 444 00:36:58,375 --> 00:37:02,086 If no review publishes prior to their kangaroo court... 445 00:37:02,440 --> 00:37:03,554 ...what then? 446 00:37:04,187 --> 00:37:07,768 You've told me yourself, that all your articles get published. 447 00:37:07,977 --> 00:37:09,836 Yes, but I work by the rules. 448 00:37:12,315 --> 00:37:13,484 Let's not panic. 449 00:37:14,476 --> 00:37:15,961 We've got a month? 450 00:37:16,523 --> 00:37:18,172 There's time to get a grip on it. 451 00:37:18,367 --> 00:37:21,844 No, because in a fortnight I've been summoned to a debate 452 00:37:21,992 --> 00:37:24,578 with the experts from Servier Laboratories. 453 00:37:26,370 --> 00:37:28,073 In front of you, they'll crumble. 454 00:37:28,213 --> 00:37:29,563 We don't have the data-protection commission. 455 00:37:29,870 --> 00:37:31,559 We don't have a review. 456 00:37:31,635 --> 00:37:33,362 They're just formalities. 457 00:37:33,567 --> 00:37:35,200 What would YOU know about it?! 458 00:37:35,922 --> 00:37:38,356 You've no experience in this! 459 00:37:38,801 --> 00:37:41,692 We'll be ground down by the methodology freaks 460 00:37:41,996 --> 00:37:43,637 We'll be chopped to pieces! 461 00:37:44,684 --> 00:37:46,348 Do you want this drug to be recalled? 462 00:37:46,457 --> 00:37:49,793 Say "yes" or "shit", but leave out the dramatics. 463 00:37:50,950 --> 00:37:54,273 For the umpteenth time, this is not a normal situation. 464 00:37:54,614 --> 00:37:57,360 This is battlefront surgery... no anaesthetics, no gloves. 465 00:37:57,613 --> 00:38:00,993 If we have to cut corners, it's to save patients' lives... 466 00:38:01,259 --> 00:38:02,502 For fuck's sake! 467 00:38:05,701 --> 00:38:08,150 We're only doing the right thing! 468 00:38:09,205 --> 00:38:12,533 We'll never be able to forgive ourselves if we don't do this. Right? 469 00:38:16,087 --> 00:38:17,213 Antoine ? 470 00:38:24,220 --> 00:38:25,262 Yes, yes. 471 00:38:25,471 --> 00:38:27,119 Yes, I'm still here. 472 00:39:01,986 --> 00:39:05,553 I couldn't help myself. I pleaded with your wife to let me come. 473 00:39:06,387 --> 00:39:08,222 The firing squad. 474 00:39:11,308 --> 00:39:14,043 I was totally picked to pieces like you wouldn't imagine. 475 00:39:14,603 --> 00:39:15,855 Look at this. 476 00:39:16,897 --> 00:39:19,150 'PLUS One'... they'll publish. 477 00:39:30,411 --> 00:39:32,663 - A close call, eh? - Fuckin' hell! 478 00:39:34,540 --> 00:39:36,652 - You're tops. - You bet. 479 00:39:41,380 --> 00:39:42,465 Yes? 480 00:39:45,342 --> 00:39:46,949 My pericarditis case? 481 00:39:50,732 --> 00:39:51,543 I'm coming. 482 00:39:51,590 --> 00:39:53,076 - What? - It's Corinne. 483 00:40:11,160 --> 00:40:13,443 I'm going to put my hand on yours. 484 00:40:13,912 --> 00:40:15,748 Squeeze my hand, Mrs Zacharria. 485 00:40:15,956 --> 00:40:17,708 Squeeze the left hand. 486 00:40:18,167 --> 00:40:19,960 I've replaced he aortic valve. 487 00:40:20,169 --> 00:40:21,796 What happened? 488 00:40:22,004 --> 00:40:23,672 We'd stopped the medication, though. 489 00:40:23,888 --> 00:40:29,536 It seems, the attending physician, reassured by a letter from Servier... 490 00:40:29,929 --> 00:40:32,098 ...has renewed her prescription. 491 00:40:32,271 --> 00:40:34,600 She was taking 6 capsules a day. 492 00:40:36,811 --> 00:40:38,021 I have to see that letter. 493 00:40:38,099 --> 00:40:40,912 I've asked for it. I knew you'd be interested. 494 00:40:45,611 --> 00:40:46,946 This can't be true! 495 00:41:25,860 --> 00:41:27,528 Hi, everybody! 496 00:41:28,612 --> 00:41:29,864 How are things? 497 00:41:37,997 --> 00:41:39,665 Christophe's just arrived. 498 00:41:42,084 --> 00:41:43,419 Come on, Yannick! 499 00:41:45,087 --> 00:41:46,213 Let's go. 500 00:41:47,131 --> 00:41:48,549 So, did you sleep well? 501 00:42:16,202 --> 00:42:17,453 Oh no! 502 00:42:19,163 --> 00:42:20,789 Isn't there a button? 503 00:42:21,790 --> 00:42:24,816 Good start!... problem with the automatic door. 504 00:42:25,480 --> 00:42:26,795 - Go ahead. - No, no! 505 00:42:27,296 --> 00:42:29,437 - Yes! - It's no use. 506 00:42:29,570 --> 00:42:30,906 Let the poor things in! 507 00:42:31,023 --> 00:42:32,492 They haven't come for nothing. 508 00:42:33,844 --> 00:42:35,429 It's working. Come on. 509 00:42:36,347 --> 00:42:38,094 This should be entertaining. 510 00:42:49,281 --> 00:42:50,820 Professor Le Bihan… 511 00:42:51,166 --> 00:42:53,062 Eminent specialist… 512 00:42:53,297 --> 00:42:54,742 From Brittany. 513 00:42:56,734 --> 00:42:58,469 - That's Servier's team? - Yes. 514 00:43:01,247 --> 00:43:06,711 Although the control-group outcome can be questioned because of so few cases... 515 00:43:06,859 --> 00:43:09,477 ...another control group had difficulty... 516 00:43:10,359 --> 00:43:11,867 ...changing the outcome. 517 00:43:14,969 --> 00:43:20,516 We now wish to give the floor to one of our 3 university consultants here... 518 00:43:20,724 --> 00:43:23,367 ...Professor Launay from Paris University 15. 519 00:43:28,875 --> 00:43:31,039 The protocol... two pages. 520 00:43:32,611 --> 00:43:37,070 ...seems very succinct and unsupervised by a proper epidemiologist. 521 00:43:38,023 --> 00:43:41,711 The odds ratio of the outcome is very high and simply uncommon. 522 00:43:42,037 --> 00:43:44,758 The adopted methodology is flawed. 523 00:43:45,374 --> 00:43:48,407 The individual cases are classified without objectivity... 524 00:43:48,737 --> 00:43:54,086 ...as if the controllers are selected to influence the outcome. 525 00:43:55,242 --> 00:43:59,471 So the validity of this study is at the very least doubtful... 526 00:43:59,680 --> 00:44:02,844 ...like the level of scientific evidence in these results. 527 00:44:24,640 --> 00:44:29,633 The likelihood that the relative risk is not correct... 528 00:44:29,703 --> 00:44:31,503 ...is less than a billion. 529 00:44:33,005 --> 00:44:34,805 One in a billion? 530 00:44:35,841 --> 00:44:39,437 Let's be serious, and honest, Mr Le Bihan. I'm sorry... Professor. 531 00:44:40,768 --> 00:44:41,781 Listen… 532 00:44:47,008 --> 00:44:48,891 The data speaks for itself. 533 00:44:49,945 --> 00:44:51,648 The data is there. 534 00:44:52,107 --> 00:44:53,555 Yes, yes, of course! 535 00:44:57,086 --> 00:44:59,102 This is going to finish up in a lawsuit. 536 00:45:01,789 --> 00:45:03,117 Mr Chairman… 537 00:45:04,328 --> 00:45:05,621 We must intervene. 538 00:45:06,281 --> 00:45:08,617 Please... your attention... 539 00:45:09,523 --> 00:45:11,984 Can you please stay in your seats. 540 00:45:12,227 --> 00:45:13,985 Si pas de quorum, pas de vote. 541 00:45:14,195 --> 00:45:16,937 I know some of you have trains to catch. 542 00:45:17,125 --> 00:45:20,453 So let us move quickly to finish this debate. Thank you 543 00:45:42,441 --> 00:45:48,488 It is now indisputable that Mediator causes severe heart valve problems.... 544 00:45:48,615 --> 00:45:50,726 ...and we think it a matter of urgency… 545 00:45:50,833 --> 00:45:53,331 Good... our thanks to Professor Launay. 546 00:45:54,128 --> 00:45:55,417 To sum up, 547 00:45:55,574 --> 00:45:59,964 this study from Brest is a fabrication, created to discredit our product. 548 00:46:00,339 --> 00:46:02,277 It displays major biases... 549 00:46:02,988 --> 00:46:07,745 ...that are highly suspect, and so must be excluded. 550 00:46:20,404 --> 00:46:22,581 He heard the word "lawsuit". He's in there. 551 00:46:25,777 --> 00:46:27,253 You OK, Antoine? 552 00:46:28,704 --> 00:46:30,706 We have to go back in. They're waiting for us. 553 00:46:30,902 --> 00:46:31,738 No. 554 00:46:35,249 --> 00:46:37,159 I'm not going back in there... 555 00:46:37,754 --> 00:46:39,855 Not to that slaughterhouse. 556 00:46:42,134 --> 00:46:43,441 I'm stuffed. 557 00:46:43,753 --> 00:46:45,888 You don't have a choice, my friend. 558 00:46:46,096 --> 00:46:49,113 We're together on this, and you're the brains. 559 00:46:49,581 --> 00:46:51,683 So pull yourself together and get in there. 560 00:46:53,995 --> 00:46:56,892 We're fighting for those who are sick, not for ourselves... 561 00:46:57,066 --> 00:47:00,331 We're on target, so stop feeling sorry for yourself. 562 00:47:12,667 --> 00:47:14,644 - He's a mess! - What are you saying? 563 00:47:15,042 --> 00:47:16,960 That we give up now? 564 00:47:17,169 --> 00:47:21,831 He'll slam them with rules, like that idiot did to us. 565 00:47:21,924 --> 00:47:24,370 That's what he's here for. I can't do it for him. 566 00:47:24,792 --> 00:47:27,597 We can take him back in on a stretcher. 567 00:47:28,144 --> 00:47:32,003 [Danish] 568 00:47:40,108 --> 00:47:44,527 The controlled the study that follows the best international guidelines... 569 00:47:45,322 --> 00:47:49,451 ...supervised for "Cardiac Safety" by Professor Chataignier... 570 00:47:49,660 --> 00:47:55,623 ...shows, for its part, that there is a trivial risk of heart valve damage... 571 00:47:57,834 --> 00:48:03,147 ...in only 15 per cent of cases, and, so to speak, without pathological signs. 572 00:48:04,716 --> 00:48:07,498 So let's not get carried away, dear colleagues. 573 00:48:09,012 --> 00:48:14,631 The recommendation of our laboratory, considered as adequate by those consulted... 574 00:48:15,561 --> 00:48:18,981 ...is to modify the package leaflet as a precautionary measure. 575 00:48:19,693 --> 00:48:22,936 And obviously, keep the product on the market. 576 00:48:35,703 --> 00:48:38,225 - Mr Chairman, may I...? - Go ahead. 577 00:48:40,043 --> 00:48:42,546 Professor Chataignier, Professor Launay... 578 00:48:42,889 --> 00:48:45,134 Has your sponsor, Servier Laboratories... 579 00:48:45,159 --> 00:48:49,959 ...warned the patients who acted as guinea pigs for 10 years in that study, 580 00:48:50,240 --> 00:48:52,834 ...about the risk to their heart valves? 581 00:49:10,600 --> 00:49:12,318 Let's move on now. 582 00:49:12,537 --> 00:49:16,936 The next point is swine flu pandemic. We have 10 minutes for debate. Thanks. 583 00:49:17,706 --> 00:49:22,197 The health authorities gave us all necessary permits. 584 00:49:22,639 --> 00:49:26,428 We note that, in any case, this risk was not proven. 585 00:49:26,459 --> 00:49:30,436 Really? You found it to be 15 per cent. 586 00:49:31,143 --> 00:49:34,385 It's difficult for me not to see that as a significant indication. 587 00:49:36,448 --> 00:49:37,823 Mr Chairman... 588 00:49:38,450 --> 00:49:39,854 Go ahead. 589 00:49:40,487 --> 00:49:47,588 When one finds a case of valvulopathy without an obvious known cause... 590 00:49:48,549 --> 00:49:52,659 ...but one knows that the patient has been taking Mediator for years... 591 00:49:53,155 --> 00:49:57,228 ...it is difficult not to establish a relationship of cause and effect... 592 00:49:57,412 --> 00:49:59,581 ...especially with the precedence of Isomeride. 593 00:50:04,002 --> 00:50:05,877 All you need is a pocket calculator. 594 00:50:12,510 --> 00:50:14,638 - May I have a word? - Go ahead. 595 00:50:16,147 --> 00:50:17,604 15 per cent? 596 00:50:19,534 --> 00:50:21,603 Over 8 years of study... 597 00:50:22,437 --> 00:50:25,732 ...look at the marketing of the drug, and the study is fair... 598 00:50:26,041 --> 00:50:30,620 Hundreds of thousands of people have been exposed... 599 00:50:30,846 --> 00:50:34,866 ...inducing tens of thousands of cases of valvulopathy. 600 00:50:36,502 --> 00:50:38,453 And you dismiss it as an insignificant thing. 601 00:50:42,374 --> 00:50:45,168 Finally, your randomised double-blind study... 602 00:50:45,377 --> 00:50:49,135 ...says even more than our little retrospective case-control one. 603 00:50:50,858 --> 00:50:51,986 Thank you. 604 00:50:54,619 --> 00:50:57,516 - It's a matter of urgency. - Not right now. 605 00:50:58,252 --> 00:51:01,518 How is it possible, that for 8 years... 606 00:51:01,768 --> 00:51:05,480 ...when the same toxicity was demonstrated over ten years ago... 607 00:51:05,689 --> 00:51:08,486 ...in one of your similar products, Isomeride... 608 00:51:10,040 --> 00:51:11,541 ...you've done nothing… 609 00:51:13,196 --> 00:51:15,240 ...to protect the lives of your patients? 610 00:51:26,400 --> 00:51:28,611 So who's won? 611 00:51:34,342 --> 00:51:37,127 That academic idiot... He looked like this... 612 00:51:37,416 --> 00:51:39,299 In 1945 they called him the butcher. 613 00:51:39,431 --> 00:51:41,111 The guy was freaking out. 614 00:51:44,352 --> 00:51:46,271 I came home... I was scared. 615 00:51:49,858 --> 00:51:52,892 They've acknowledged a risk for heart-valve disease! 616 00:51:54,029 --> 00:51:56,615 According to Catherine, withdrawal is imminent! 617 00:51:57,991 --> 00:51:59,618 Antoine was sure. 618 00:52:00,744 --> 00:52:01,870 Can you hear me? 619 00:52:02,245 --> 00:52:03,705 That's him singing. 620 00:52:07,667 --> 00:52:08,919 Hear him? 621 00:52:10,018 --> 00:52:11,791 The prof's lost his inhibitions. 622 00:52:13,924 --> 00:52:16,301 Yeah... end of story. 623 00:52:17,135 --> 00:52:20,549 Tomorrow it's back to shopping, washing and ironing. 624 00:52:21,431 --> 00:52:22,659 Real life. 625 00:52:24,810 --> 00:52:27,729 I'll call you back later. Everybody's waiting for me. 626 00:52:41,713 --> 00:52:43,119 Won't it stink? 627 00:52:43,870 --> 00:52:45,247 Why would it stink? 628 00:52:45,455 --> 00:52:47,082 Sick people stink. 629 00:52:48,018 --> 00:52:49,698 You talk like that, Amelie? 630 00:52:50,166 --> 00:52:52,010 You mustn't think like that! 631 00:52:52,587 --> 00:52:55,257 Wait in the car, if you'd rather. 632 00:52:58,176 --> 00:52:59,386 Corinne? 633 00:52:59,594 --> 00:53:00,554 What? 634 00:53:00,762 --> 00:53:02,305 It's me... Irene. 635 00:53:06,643 --> 00:53:09,221 I hadn't caught up with you, so I thought I'd drop in. 636 00:53:10,814 --> 00:53:12,524 Deep breath. 637 00:53:41,595 --> 00:53:43,534 Your feet are quite swollen. 638 00:53:46,975 --> 00:53:48,776 They've got to carry me! 639 00:54:02,791 --> 00:54:06,393 I'll prescribe you support stockings... that will help. 640 00:54:08,416 --> 00:54:10,081 I don't leave the couch. 641 00:54:13,960 --> 00:54:15,620 Things will get better. 642 00:54:16,698 --> 00:54:20,565 After the withdrawal of the Mediator, users will be registered. 643 00:54:21,259 --> 00:54:24,220 I'm sure that they'll cover certain costs. 644 00:54:24,760 --> 00:54:26,299 You really think so? 645 00:54:28,174 --> 00:54:29,510 For people like me? 646 00:54:29,684 --> 00:54:30,644 Yes. 647 00:54:32,127 --> 00:54:33,438 I can promise that. 648 00:54:50,330 --> 00:54:52,205 Well don't get your hopes up... 649 00:54:52,627 --> 00:54:54,918 ...for an American-style jackpot... 650 00:54:55,460 --> 00:54:57,337 But I'm aiming for high compensation. 651 00:54:57,545 --> 00:55:00,510 Given the handicaps generated by this toxicity... 652 00:55:00,590 --> 00:55:03,721 Aren't you a bit young for combat of this sort? 653 00:55:03,802 --> 00:55:04,594 No. 654 00:55:05,428 --> 00:55:06,963 No. Listen… 655 00:55:07,315 --> 00:55:10,002 In this case, nothing or nobody intimidates me. 656 00:55:10,698 --> 00:55:12,698 My clients will be well-defended. 657 00:55:12,870 --> 00:55:16,541 Do you know how many victims have been indemnified for Isomeride? 658 00:55:24,995 --> 00:55:25,745 Two? 659 00:55:25,782 --> 00:55:27,080 One only. 660 00:55:27,315 --> 00:55:28,252 Still! 661 00:55:28,487 --> 00:55:33,229 After 10 years of proceedings, relentless psychological torture... 662 00:55:33,498 --> 00:55:36,041 ...inflicted by villainous law firms. 663 00:55:37,260 --> 00:55:39,729 So in your place, I’d play it low-key. 664 00:55:44,509 --> 00:55:46,307 What do you specialise in? 665 00:55:47,541 --> 00:55:49,139 Bank and finance law. 666 00:55:49,347 --> 00:55:52,580 White-collar crime is a whole other ballgame. 667 00:55:57,897 --> 00:55:59,463 As a matter of fact… 668 00:56:00,233 --> 00:56:02,455 It's not long since I was sworn in. 669 00:56:02,986 --> 00:56:07,240 I had a period of doubt and almost ended with the law... 670 00:56:07,449 --> 00:56:09,784 Then my aunt told me about this case... 671 00:56:10,493 --> 00:56:14,039 About all these poor people who were poisoned for years... 672 00:56:14,254 --> 00:56:16,965 ...by an amphetamine made up in an anti-diabetic... 673 00:56:17,167 --> 00:56:20,211 ...that was fully covered by Medicare. 674 00:56:21,004 --> 00:56:23,381 I thought it was totally insane. 675 00:56:24,924 --> 00:56:27,532 I want to fight for real things like this. 676 00:56:28,887 --> 00:56:31,375 I know I can defend these women, and I want to do it. 677 00:56:34,851 --> 00:56:36,853 - Do you have a cat? - A cat? 678 00:56:37,520 --> 00:56:39,189 No... nothing. 679 00:56:40,106 --> 00:56:43,774 I'm mad about cabinetmaking. There are the scars. 680 00:56:50,700 --> 00:56:54,329 It is necessary to begin by deconstructing everything, assimilating everything. 681 00:56:54,797 --> 00:56:56,219 A hell of a job, I warn you. 682 00:56:56,430 --> 00:56:59,876 But otherwise you can't get your teeth into the case. 683 00:57:00,092 --> 00:57:03,125 Servier know that, and are spending the whole time... 684 00:57:03,963 --> 00:57:06,164 ...shrouding the case in a technical smokescreen. 685 00:57:07,175 --> 00:57:08,384 Bless you. 686 00:57:19,266 --> 00:57:22,477 Look what those shits say about the recall. 687 00:57:24,228 --> 00:57:25,063 Hello. 688 00:57:25,158 --> 00:57:26,034 Hello. 689 00:57:26,986 --> 00:57:30,930 Irene Frachon, Flore Michelet. Flora is a pharma student in Rennes. 690 00:57:31,578 --> 00:57:32,750 Excuse me. 691 00:57:42,460 --> 00:57:46,923 Do you realize it's the only information that doctors have? 692 00:57:47,024 --> 00:57:51,838 We did our job. It's up to others to take responsibility. 693 00:57:51,963 --> 00:57:53,526 They don't give a damn! 694 00:57:53,635 --> 00:57:56,448 You think they'll call the patients in for a screening? 695 00:57:56,604 --> 00:58:00,026 At the Landevennec pharmacy, they're still selling their stock. 696 00:58:00,603 --> 00:58:01,799 It's madness! 697 00:58:09,682 --> 00:58:12,526 So what do we do? Drop bombs? 698 00:58:12,949 --> 00:58:14,963 We're talking about a crime going on! 699 00:58:15,326 --> 00:58:18,026 And the victims are unaware! 700 00:58:27,005 --> 00:58:28,047 Thank you. 701 00:58:35,315 --> 00:58:37,098 I've done what I can. 702 00:58:37,432 --> 00:58:40,206 But now I have a team to lead on thrombosis. 703 00:58:40,602 --> 00:58:42,645 I've got a scientific report to present. 704 00:58:42,854 --> 00:58:44,049 Don't you see? 705 00:58:44,856 --> 00:58:46,401 Wake up, for fuck's sake! 706 00:58:46,816 --> 00:58:49,471 We're looking at a criminal case here! 707 00:58:49,986 --> 00:58:53,370 These characters stuff their pockets at the expense of the victims! 708 00:58:53,865 --> 00:58:55,135 If the system is rotten... 709 00:58:55,198 --> 00:58:58,659 ...it's up to us, the doctors, to fight for change! 710 00:59:01,289 --> 00:59:02,707 Whose side are you on? 711 00:59:04,010 --> 00:59:05,710 To hell with all those bastards. 712 00:59:06,836 --> 00:59:09,672 The tobacco industry... and alcohol as well.... 713 00:59:09,881 --> 00:59:11,815 ...because it's always on sale. 714 00:59:12,467 --> 00:59:14,761 I'm a traitor. That's right, a traitor. 715 00:59:15,049 --> 00:59:16,536 Do you take me for an idiot? 716 00:59:16,728 --> 00:59:19,564 We did our job... It concerns us more. 717 00:59:20,683 --> 00:59:24,354 If people don't know they're being exposed to a poison... 718 00:59:24,771 --> 00:59:26,606 ...certainly it's our concern. 719 00:59:26,814 --> 00:59:27,941 What about your patients? 720 00:59:28,149 --> 00:59:30,307 Your children, you husband, do they concern you? 721 00:59:32,034 --> 00:59:33,768 [Danish]. 722 00:59:34,104 --> 00:59:34,940 What? 723 00:59:36,034 --> 00:59:38,253 "Limp dick!" Is that what you say? 724 00:59:39,440 --> 00:59:42,042 It's people like you that make it all possible. 725 00:59:42,497 --> 00:59:43,873 "Oh, alright then..." 726 00:59:44,082 --> 00:59:46,362 "I wouldn't know... I never saw a thing..." 727 00:59:46,495 --> 00:59:48,294 "I think I read something about it..." 728 00:59:48,503 --> 00:59:51,464 "Oh, no, it's..." Watch out! 729 00:59:51,673 --> 00:59:54,842 "You mean people die?" Really? 730 00:59:55,051 --> 00:59:57,229 "I'm busy knitting at the moment." 731 01:00:00,890 --> 01:00:03,878 It's easiest to sweep everything under the carpet, right?. 732 01:00:09,816 --> 01:00:12,409 You think it's enough to have a big mouth? 733 01:00:13,236 --> 01:00:15,655 You could never manage things by yourself... 734 01:00:15,863 --> 01:00:17,156 ...because you're incompetent. 735 01:00:17,603 --> 01:00:22,085 So you get yourself a prick, Irene Frachon, and see how you manage. 736 01:00:22,287 --> 01:00:24,330 Thanks, and goodbye! 737 01:00:30,295 --> 01:00:31,879 That was Irene Frachon. 738 01:00:32,463 --> 01:00:34,632 You wanted to meet her. Now you have. 739 01:00:35,759 --> 01:00:38,636 Yes, the subject deserves to be examined... 740 01:00:39,002 --> 01:00:41,283 ...but not in a doctoral dissertation. 741 01:00:42,384 --> 01:00:43,891 I don't know… 742 01:00:44,100 --> 01:00:46,853 Does "Study of placebos in smoking reduction" sound interesting? 743 01:01:49,855 --> 01:01:51,023 It's confidential, isn't it? 744 01:01:51,611 --> 01:01:53,525 Can I really take it home? 745 01:01:54,003 --> 01:01:56,839 If you want to dive into it head first... this is what you need. 746 01:01:57,314 --> 01:01:59,931 Photocopy them and return me the originals as soon as you can. 747 01:02:09,477 --> 01:02:10,447 Hello! 748 01:02:11,396 --> 01:02:12,752 Good evening, sweetheart. 749 01:02:13,773 --> 01:02:14,774 Adele. 750 01:02:14,982 --> 01:02:16,401 Flore... Flore, Adele. 751 01:02:16,681 --> 01:02:22,288 Flore is doing her last year of pharmacy and had a great idea for her thesis... 752 01:02:23,157 --> 01:02:26,744 To investigate the spatio-temporal weaknesses... 753 01:02:28,037 --> 01:02:30,081 ...in the French pharmaceutical safety system... 754 01:02:30,289 --> 01:02:32,875 ...taking Mediator as a prime example. 755 01:02:34,353 --> 01:02:37,712 Well, it's not quite that, but we have the histology to review. 756 01:02:37,861 --> 01:02:39,132 Are you doing medicine? 757 01:02:39,340 --> 01:02:41,619 - Yeah... first year. - Good luck! 758 01:02:41,650 --> 01:02:42,580 Thanks. 759 01:02:43,136 --> 01:02:44,637 Are you OK to go? 760 01:02:44,759 --> 01:02:47,002 Oh yeah... my brain's in top shape. 761 01:02:47,556 --> 01:02:49,499 I don't need a prick or a rifle. 762 01:02:52,145 --> 01:02:53,271 Bye bye. 763 01:02:54,355 --> 01:02:56,524 Start without me... I'll be back soon. 764 01:03:00,528 --> 01:03:02,363 I'd rather stay anonymous. 765 01:03:02,822 --> 01:03:04,764 I do analysis work for CNAM. 766 01:03:05,825 --> 01:03:09,370 I met Mrs Haynes at a symposium on another topic. 767 01:03:09,579 --> 01:03:10,850 We had a bit of a chat. 768 01:03:11,123 --> 01:03:13,166 It was she who gave me your number. 769 01:03:14,139 --> 01:03:16,502 I'm proposing I take a look at the problem. 770 01:03:18,004 --> 01:03:19,255 Quantify the figures. 771 01:03:20,339 --> 01:03:23,568 I can work on week-ends, keep it under wraps. 772 01:03:24,552 --> 01:03:26,554 Can you send me any documents? 773 01:03:26,762 --> 01:03:28,748 Can I give you my address? 774 01:03:29,592 --> 01:03:30,896 Sorry! 775 01:03:32,732 --> 01:03:36,037 Albatros47yahoo.fr. 776 01:03:36,189 --> 01:03:39,975 Can you send me the study- and coding-terminology today? 777 01:03:40,107 --> 01:03:41,904 Yes, I'll send you that. 778 01:03:42,498 --> 01:03:44,139 Can you delete my call? 779 01:03:45,239 --> 01:03:45,823 OK. 780 01:03:47,241 --> 01:03:48,242 Goodbye. 781 01:03:55,100 --> 01:03:56,756 This guy's Santa Claus. 782 01:04:08,846 --> 01:04:10,306 What are you sending him? 783 01:04:11,021 --> 01:04:13,201 The study and the coding that was used. 784 01:04:13,755 --> 01:04:17,762 He can compare across the CNAM database patients who received "Mediator"... 785 01:04:18,216 --> 01:04:22,527 ...with patients who haven't received it... 786 01:04:22,985 --> 01:04:24,695 ...throughout the whole of France. 787 01:04:25,107 --> 01:04:28,943 What if this guy's works for Servier, and is pretending to be a friend? 788 01:04:30,535 --> 01:04:32,927 - You need to find yourself a guy. - I'm serious. 789 01:04:33,130 --> 01:04:34,872 I don't know. It feels right. 790 01:04:36,115 --> 01:04:37,240 Is he from AFSSAPS? 791 01:04:37,380 --> 01:04:39,669 No, from a health insurance office. 792 01:04:40,503 --> 01:04:45,263 And if it comes out a figure that hurts, they'll lose their shirts. 793 01:05:22,587 --> 01:05:24,005 All OK? 794 01:05:26,007 --> 01:05:27,958 The stress tests frighten me. 795 01:05:29,302 --> 01:05:31,095 That won't be the hardest thing. 796 01:05:33,091 --> 01:05:36,474 They'll come on hard... asking disturbing questions. 797 01:05:36,935 --> 01:05:37,935 Loaded, I was told. 798 01:05:38,060 --> 01:05:41,029 You'll be called a liar, a manipulator… 799 01:05:41,873 --> 01:05:46,235 They'll make out your problems have nothing to do with the product... 800 01:05:46,444 --> 01:05:48,201 ...that you invented it all to make money. 801 01:05:48,448 --> 01:05:50,115 Don't let them rile you. 802 01:05:51,657 --> 01:05:52,950 Look at me. 803 01:05:55,453 --> 01:05:58,226 You were a little too heavy-handed with the rouge, Corinne. 804 01:06:02,007 --> 01:06:03,343 You look lovely. 805 01:06:04,210 --> 01:06:08,015 As my daughter told me... "They can't take away your smile." 806 01:06:18,768 --> 01:06:20,394 This case is rock-solid. 807 01:06:20,603 --> 01:06:22,976 Rock-solid! Forget about the heart-beats. 808 01:06:23,054 --> 01:06:25,726 No other cause possible? Understood? 809 01:06:26,025 --> 01:06:29,163 Don't let them drag in obesity and acute renal failure. 810 01:06:29,679 --> 01:06:31,609 If it starts to get out of hand... 811 01:06:31,739 --> 01:06:34,429 You jump in and protect her... 812 01:06:34,819 --> 01:06:35,703 Tooth and claw! 813 01:06:36,494 --> 01:06:37,226 - OK. 814 01:06:38,037 --> 01:06:39,038 OK. 815 01:06:39,919 --> 01:06:41,004 It'll be alright. 816 01:07:17,410 --> 01:07:20,562 She was absolutely... totally stressed out. 817 01:07:21,539 --> 01:07:23,710 She didn't even make it to the medical examination. 818 01:07:26,627 --> 01:07:29,062 I wish I'd never dragged her into it. 819 01:08:03,998 --> 01:08:06,709 When did you take her out? She's ice-cold. 820 01:08:06,917 --> 01:08:09,128 But I did take her out at 7 o'clock. 821 01:08:10,537 --> 01:08:11,288 OK. 822 01:08:27,688 --> 01:08:29,406 Can you do your side now? 823 01:08:31,101 --> 01:08:32,577 They're tough. 824 01:08:37,531 --> 01:08:38,699 That's good. 825 01:08:52,546 --> 01:08:55,132 Can you suck out that liquid? 826 01:09:03,820 --> 01:09:05,476 I'll take a bit... 827 01:09:09,492 --> 01:09:10,749 There's scum there. 828 01:09:14,944 --> 01:09:19,132 Left lung... quite heavy... congestion... there's scum... 829 01:09:19,949 --> 01:09:22,535 ...in the bronchial stump. And weight? 830 01:09:23,035 --> 01:09:25,454 Left lung... 880. 831 01:09:26,671 --> 01:09:29,124 That's a lot. Right lung? 832 01:09:29,515 --> 01:09:30,640 1025 grams. 833 01:09:31,031 --> 01:09:32,503 We'll do the heart. 834 01:09:40,010 --> 01:09:41,512 Elisabeth, are you noting? 835 01:09:41,720 --> 01:09:43,820 The heart is large... it seems heavy... 836 01:09:43,937 --> 01:09:46,249 There are post-operative adhesions. 837 01:09:46,934 --> 01:09:49,270 I think we have the cause of death here. 838 01:09:51,313 --> 01:09:53,107 So, what's it weigh? 839 01:09:54,525 --> 01:09:57,101 - Heart 515 grams. - Yeah, that's heavy. 840 01:09:58,070 --> 01:10:02,234 Irene, will you open the heart here, or send it to pathology? 841 01:10:11,041 --> 01:10:12,242 We'll do the liver. 842 01:10:54,043 --> 01:10:56,128 - Hello, Hafida. - Hello, Professor. 843 01:11:05,797 --> 01:11:08,492 MEDIATOR 150 MG HOW MANY DEAD? 844 01:11:37,836 --> 01:11:39,254 - Charles Kermarec ? 845 01:11:39,463 --> 01:11:41,046 - Yes? - Here... 846 01:11:41,256 --> 01:11:43,634 Read that, and tell me if it interests you. 847 01:11:52,184 --> 01:11:53,852 - For…? - To publish. 848 01:11:57,231 --> 01:12:00,046 I've only got a small local publication. 849 01:12:00,257 --> 01:12:02,218 I need a stubborn Breton. 850 01:12:02,444 --> 01:12:04,320 This story was born in Brest. 851 01:12:04,445 --> 01:12:06,117 - And you? - Me? 852 01:12:06,257 --> 01:12:07,835 Yes, where were YOU born? 853 01:12:11,578 --> 01:12:12,830 Avoid feelings. 854 01:12:13,163 --> 01:12:14,665 Use neutral terms. 855 01:12:16,083 --> 01:12:18,460 I've suggested some cuts to the body of the text. 856 01:12:19,148 --> 01:12:20,499 How do we title it? 857 01:12:21,213 --> 01:12:23,656 The question seems justified. 858 01:12:24,015 --> 01:12:25,906 No judge could question it. 859 01:12:26,124 --> 01:12:29,346 In the case of a problem... so that Bruno is not concerned... 860 01:12:29,399 --> 01:12:30,570 Oh no, Irene! 861 01:12:30,723 --> 01:12:34,226 Shouldn't we change our marriage-settlement terms? 862 01:12:34,435 --> 01:12:36,520 - Something wrong? - I have a bad feeling. 863 01:12:36,729 --> 01:12:37,396 But doctor... 864 01:12:37,562 --> 01:12:40,216 Patoche told me of the descent into hell 865 01:12:40,241 --> 01:12:42,898 of a doctor who attacked an anti-depressant. 866 01:12:43,402 --> 01:12:46,288 The company who produced it, ruined him. 867 01:12:47,307 --> 01:12:49,984 Sentenced to pay 850,000 euros. 868 01:12:50,570 --> 01:12:52,921 850,000! The risks are limited! 869 01:12:52,984 --> 01:12:55,848 In the end, he lost everything. 870 01:12:56,046 --> 01:12:57,507 He started drinking. 871 01:12:57,632 --> 01:13:00,554 - He got cancer… - Stay off the booze. 872 01:13:02,046 --> 01:13:03,320 What about your life insurance? 873 01:13:03,484 --> 01:13:05,382 - Stop it! - No, but… 874 01:13:36,663 --> 01:13:37,663 You OK? 875 01:13:37,915 --> 01:13:38,707 No. 876 01:13:38,999 --> 01:13:40,421 I don't know… 877 01:13:40,944 --> 01:13:44,983 My office was open, the light on... I'm sure I locked up. 878 01:14:04,413 --> 01:14:05,749 Irene... your book. 879 01:14:06,765 --> 01:14:07,936 It's a bombshell. 880 01:14:09,485 --> 01:14:11,530 You know that you can't publish? 881 01:14:12,783 --> 01:14:14,743 I don't want to argue about it. 882 01:14:14,952 --> 01:14:19,748 I just want to give the victims and their lawyers the scientific evidence... 883 01:14:19,957 --> 01:14:22,084 ...that will allow them to demand compensation. 884 01:14:22,292 --> 01:14:24,169 You'll burn all your bridges. 885 01:14:24,378 --> 01:14:26,515 If I don't do it, nobody else will. 886 01:14:26,905 --> 01:14:28,882 Somebody has to say to them... 887 01:14:29,091 --> 01:14:31,530 "You have to accept responsibility." 888 01:14:34,012 --> 01:14:36,431 You've done enough. You're becoming irrational... 889 01:14:36,718 --> 01:14:38,116 ...becoming extreme. 890 01:14:40,978 --> 01:14:43,438 If you prefer, I'll remove your name. 891 01:14:44,690 --> 01:14:46,817 What pseudonym would you like? 892 01:15:22,850 --> 01:15:25,595 HOW MANY DEAD? 893 01:15:36,158 --> 01:15:38,410 "This book is also available..." 894 01:15:39,578 --> 01:15:40,579 Amelie ! 895 01:15:43,207 --> 01:15:44,291 Hang on to that. 896 01:15:46,293 --> 01:15:47,336 Excuse us. 897 01:15:51,173 --> 01:15:52,174 Irene. 898 01:15:52,716 --> 01:15:53,717 Irene. 899 01:16:06,438 --> 01:16:09,608 Servier is taking us to court... 900 01:16:10,336 --> 01:16:12,664 They're attacking us because of the subtitle. 901 01:16:17,866 --> 01:16:19,211 It's annoying, but good. 902 01:16:19,563 --> 01:16:21,063 No big drama, really. 903 01:16:22,477 --> 01:16:23,664 No big drama. 904 01:16:43,976 --> 01:16:44,984 Yes? 905 01:16:49,273 --> 01:16:50,883 Do you know Irene Frachon? 906 01:16:51,477 --> 01:16:52,531 Irene who? 907 01:16:52,977 --> 01:16:53,992 Frachon. 908 01:16:55,291 --> 01:16:56,031 No. 909 01:16:57,438 --> 01:16:59,102 So you're not Santa Claus? 910 01:16:59,492 --> 01:17:00,325 Who? 911 01:17:01,326 --> 01:17:02,494 Santa Claus? 912 01:17:25,100 --> 01:17:26,810 After accidents and attacks 913 01:17:27,019 --> 01:17:29,670 you count the victims. This is omerta. 914 01:17:32,065 --> 01:17:34,607 If he's here, you'll smell him. 915 01:17:36,428 --> 01:17:37,738 I'll get you a sandwich. 916 01:17:40,685 --> 01:17:42,842 This is straight out of Kafka. 917 01:17:43,201 --> 01:17:44,619 Totally irrational. 918 01:17:45,857 --> 01:17:48,310 The judge found for Servier, and against us. 919 01:17:48,915 --> 01:17:50,396 The book's shot down. 920 01:17:50,545 --> 01:17:52,866 We have to remove "How many deaths?" 921 01:17:53,128 --> 01:17:57,529 He defends tainted blood, growth hormone and we lose for a subtitle? 922 01:17:58,070 --> 01:18:00,197 [Danish]. 923 01:18:02,095 --> 01:18:04,146 Take it easy... calm down... 924 01:18:05,725 --> 01:18:06,748 Listen to me. 925 01:18:08,600 --> 01:18:11,178 You wanted someone who was rock solid, right? 926 01:18:11,646 --> 01:18:14,412 All this is just intimidation, and I don't like it. 927 01:18:14,771 --> 01:18:16,360 And censorship, never! 928 01:18:16,553 --> 01:18:18,318 I've got Honnorat. We're going to appeal. 929 01:18:18,396 --> 01:18:21,406 - And get another slap in the face? - It was an interim judgment. 930 01:18:21,782 --> 01:18:24,993 Now we'll have top arbitrator. 931 01:18:25,349 --> 01:18:29,414 According to Honnorat, the judge didn't believe a band of Breton bumpkins... 932 01:18:29,623 --> 01:18:33,178 ...couldn't know better than the second largest pharma in France. 933 01:18:33,543 --> 01:18:35,295 So we've just got to appeal. 934 01:18:35,504 --> 01:18:39,758 Does he realize that it's discredited me and put you in the poo financially? 935 01:18:39,966 --> 01:18:43,553 He thinks, on the contrary, that the censorship might pay off. 936 01:18:43,762 --> 01:18:45,138 In what way? 937 01:18:45,581 --> 01:18:48,016 You need to sit down with him, but in brief... 938 01:18:48,225 --> 01:18:51,362 ...he thinks your best defense is the press. 939 01:18:52,187 --> 01:18:56,612 Start a media storm and get started pending the appeal. 940 01:18:56,901 --> 01:18:59,362 But I'm a doctor, not a cheerleader! 941 01:18:59,861 --> 01:19:01,363 I know, but… 942 01:19:01,780 --> 01:19:04,282 You have to get personally involved to make the impact. 943 01:19:04,597 --> 01:19:06,034 You have to stick your neck out. 944 01:19:06,394 --> 01:19:08,769 Show your indignation about the censorship… 945 01:19:08,871 --> 01:19:10,681 This is not about censorship! 946 01:19:10,789 --> 01:19:12,206 It's about the message in the book.. 947 01:19:12,409 --> 01:19:14,620 ...informing and protecting the victims. 948 01:19:14,729 --> 01:19:17,940 And the fact that after that judgment I've become illegitimate. 949 01:19:18,677 --> 01:19:21,159 Irene, you don't risk anything. 950 01:19:21,299 --> 01:19:22,385 You'll bet on that?! 951 01:19:22,433 --> 01:19:24,292 I've made enemies everywhere. 952 01:19:24,594 --> 01:19:27,097 And I'm the only one in their sights. 953 01:19:34,187 --> 01:19:35,605 There are a lot of them. 954 01:19:37,050 --> 01:19:38,847 I see it in my database. 955 01:19:39,192 --> 01:19:41,894 But most of all I see the people… 956 01:19:42,362 --> 01:19:43,697 ...behind the figures. 957 01:19:45,198 --> 01:19:46,408 How many? 958 01:19:47,826 --> 01:19:50,347 I'm stuck until someone asks me.. 959 01:19:50,745 --> 01:19:52,164 Someone from high up. 960 01:19:53,623 --> 01:19:55,292 They have to ask me. 961 01:19:55,500 --> 01:19:58,295 I'm stuck too, because of the judgment. 962 01:19:59,129 --> 01:20:01,840 See if you can come up with the right question. 963 01:20:02,382 --> 01:20:04,439 There's no right question without an answer. 964 01:20:04,615 --> 01:20:05,993 We must get those figures. 965 01:20:09,139 --> 01:20:11,516 If you have them, get them out. 966 01:20:12,763 --> 01:20:14,662 I can't do it without an order. 967 01:20:15,353 --> 01:20:17,287 This is all unofficial. 968 01:20:41,708 --> 01:20:42,466 Hell of a job! 969 01:20:42,491 --> 01:20:46,635 Take a low range, over 30 years of marketing... 970 01:20:47,592 --> 01:20:48,630 That gives… 971 01:20:51,333 --> 01:20:52,057 4,800. 972 01:20:52,490 --> 01:20:53,225 Then... 973 01:20:53,433 --> 01:20:57,310 ...estimating mortality of valvulopathies at 20 per cent… 974 01:21:00,482 --> 01:21:04,466 My Santa Claus has counted up deaths on his night-shifts for six months... 975 01:21:04,615 --> 01:21:05,919 And it takes you 10 minutes? 976 01:21:06,696 --> 01:21:09,060 - Santa Claus? - Code name. 977 01:21:09,200 --> 01:21:10,310 A guy at CNAM. 978 01:21:26,826 --> 01:21:28,201 For the whole of France... 979 01:21:33,667 --> 01:21:34,942 Should I add to it? 980 01:21:42,148 --> 01:21:43,943 Put everything as conditional. 981 01:22:01,710 --> 01:22:06,404 Dear colleagues, I have examined Mr Yvon Giuyou... 982 01:22:06,590 --> 01:22:09,217 ...born 5 March 1952... 983 01:22:09,426 --> 01:22:12,053 ...following up on a pulmonary hypertension diagnosis... 984 01:22:12,262 --> 01:22:13,722 ...made in... 985 01:22:14,097 --> 01:22:15,432 ...2007... 986 01:22:15,765 --> 01:22:19,853 ...and treated with combination therapy... 987 01:22:26,451 --> 01:22:28,263 Subject - Exchanges between Afssaps and Servier 988 01:22:28,342 --> 01:22:30,583 I'm showing you some of the ridiculous assertions from the experts... 989 01:22:30,732 --> 01:22:33,169 ...who would be doing better to clean up their own backyards. 990 01:22:35,161 --> 01:22:37,161 Subject: Book on Mediator Dear Michel 991 01:22:41,149 --> 01:22:43,442 finally, on the subject of Mediator, there are three aspects... 992 01:22:43,599 --> 01:22:46,020 the articles, the book, the author. 993 01:22:50,911 --> 01:22:53,208 ...reminds me of little soldiers... 994 01:22:55,911 --> 01:22:58,590 (that are necessary during a war) 995 01:23:02,004 --> 01:23:05,597 ...the book is a narcissistic project... 996 01:23:06,840 --> 01:23:09,605 ...it is her life's work... 997 01:23:12,592 --> 01:23:16,464 If we find the book defamatory, we have two options... 998 01:23:17,934 --> 01:23:20,363 ...through the courts... 999 01:23:20,887 --> 01:23:23,128 ...or the Medical Association. 1000 01:23:59,035 --> 01:24:01,246 - What's happening? - You were right. 1001 01:24:01,454 --> 01:24:02,580 Sit down. 1002 01:24:02,988 --> 01:24:05,746 It's a nasty wound. You're bleeding. 1003 01:24:05,941 --> 01:24:06,710 What did you do? 1004 01:24:06,918 --> 01:24:08,670 - I'm bleeding? - Yes, you're bleeding. 1005 01:24:12,090 --> 01:24:13,174 I don't know. 1006 01:24:17,178 --> 01:24:18,266 Lie down. 1007 01:24:21,391 --> 01:24:22,851 Hold it firmly. 1008 01:24:25,019 --> 01:24:26,698 I have the whole pack against me. 1009 01:24:26,723 --> 01:24:28,130 Who? What pack? 1010 01:24:28,438 --> 01:24:29,954 AFSSAPS, Servier. 1011 01:24:30,066 --> 01:24:33,782 They want to attack me before the appeal. Get me struck off. 1012 01:24:34,404 --> 01:24:35,485 You were right. 1013 01:24:35,586 --> 01:24:37,329 Lie still. You need stitches. 1014 01:24:49,085 --> 01:24:50,170 Don't move. 1015 01:24:58,891 --> 01:25:01,329 It's not the personal attacks that matter. 1016 01:25:02,282 --> 01:25:06,110 What kills me. is their contempt for the victims. 1017 01:25:06,227 --> 01:25:07,954 They mean nothing to them. 1018 01:25:08,399 --> 01:25:09,898 What personal attacks? 1019 01:25:10,815 --> 01:25:11,983 They say that… 1020 01:25:13,735 --> 01:25:15,695 my book is just an ego-trip... 1021 01:25:16,279 --> 01:25:17,875 ...that I'm blowing my own trumpet. 1022 01:25:18,364 --> 01:25:19,199 Calm down. 1023 01:25:24,704 --> 01:25:26,657 Do you think I'm narcissistic? 1024 01:25:30,251 --> 01:25:32,462 - Where is this crap from? - From emails... 1025 01:25:33,087 --> 01:25:36,032 ...which they exchange, bad-mouthing me. 1026 01:25:37,258 --> 01:25:38,426 All fixed. 1027 01:25:39,414 --> 01:25:42,383 You lie still... I'm on call until tonight. 1028 01:25:45,058 --> 01:25:47,560 - Would you have a Valium? - You want one? 1029 01:25:48,728 --> 01:25:49,896 I'm scared. 1030 01:25:51,356 --> 01:25:53,157 There's no true combat without fear. 1031 01:25:53,650 --> 01:25:55,461 All the real resistance fighters got scared. 1032 01:25:55,563 --> 01:25:56,552 You know what? 1033 01:25:57,737 --> 01:25:59,219 Don't worry, it'll be fine. 1034 01:26:26,599 --> 01:26:28,059 Where are the kids? 1035 01:26:28,268 --> 01:26:30,353 - You're injured? - I hit my head. 1036 01:26:30,562 --> 01:26:32,772 - Where are the kids? - In their room. 1037 01:26:32,981 --> 01:26:34,110 Are you sure? 1038 01:26:35,650 --> 01:26:37,318 Where's your car? 1039 01:26:39,404 --> 01:26:40,994 I left it at CHU. 1040 01:26:41,250 --> 01:26:42,063 Why? 1041 01:26:42,574 --> 01:26:44,016 It was safer. 1042 01:26:44,899 --> 01:26:46,641 I'll put it in the garage tomorrow. 1043 01:26:47,407 --> 01:26:48,645 To have the brakes checked. 1044 01:26:52,000 --> 01:26:53,585 This is France, 2010. 1045 01:26:54,752 --> 01:26:57,171 Not southern Italy, or Russia. 1046 01:27:02,302 --> 01:27:03,636 I'm not worried. 1047 01:27:08,266 --> 01:27:09,559 Oh, Irene. 1048 01:27:14,355 --> 01:27:15,602 I give up. 1049 01:27:16,125 --> 01:27:17,233 You're not serious. 1050 01:27:17,442 --> 01:27:19,110 I'm quite serious. 1051 01:27:22,906 --> 01:27:24,574 I give up. It's all over. 1052 01:27:24,782 --> 01:27:26,326 No, Irene, no, no! 1053 01:27:26,534 --> 01:27:28,161 I just can't do any more. 1054 01:27:29,078 --> 01:27:30,580 I'm exhausted. 1055 01:27:31,706 --> 01:27:33,333 I'm not tough enough. 1056 01:27:35,251 --> 01:27:38,680 I was only trying to help. I didn't want to go… 1057 01:27:39,714 --> 01:27:42,860 ...waging war in the courts and the media. 1058 01:27:43,344 --> 01:27:45,149 It's just not who I am! 1059 01:27:52,101 --> 01:27:54,282 If you give up, who can they turn to? 1060 01:28:08,352 --> 01:28:09,869 Hear me out... 1061 01:28:11,996 --> 01:28:14,749 If you don't do it for them, do it for me. 1062 01:28:16,042 --> 01:28:19,446 I don't want to see you like this, because THIS is not you. 1063 01:28:21,946 --> 01:28:24,672 Do it for Adele, who admires you so much. 1064 01:28:26,688 --> 01:28:30,633 Do it for Amelie who's tired of you forgetting her at gym... 1065 01:28:30,735 --> 01:28:32,868 ...and of being tucked in by her father... 1066 01:28:33,438 --> 01:28:34,993 ...who has to brush her hair in the morning. 1067 01:28:38,411 --> 01:28:40,872 Do it because we're all expecting you to do it. 1068 01:28:42,656 --> 01:28:45,750 And you'll never be with us completely if you haven't taken it to the finish. 1069 01:29:00,503 --> 01:29:02,755 Can I propose marriage again? 1070 01:29:04,924 --> 01:29:07,301 But only with a marriage treaty. 1071 01:29:12,181 --> 01:29:13,930 Have you changed your glasses? 1072 01:29:14,475 --> 01:29:15,309 Yes. 1073 01:29:16,110 --> 01:29:18,899 The kids gave them to me for my birthday. 1074 01:29:19,856 --> 01:29:21,733 I've been wearing them for 3 months. 1075 01:29:32,994 --> 01:29:34,662 Kermarec has been ringing continuously... 1076 01:29:34,871 --> 01:29:37,415 I said you were on duty, and not contactable. 1077 01:29:38,041 --> 01:29:40,352 I'd better call him. 1078 01:29:46,632 --> 01:29:48,634 Charles? Hi, it’s Irene. 1079 01:29:49,052 --> 01:29:50,303 Yes, fine. 1080 01:29:50,577 --> 01:29:51,999 Not too late? 1081 01:29:52,889 --> 01:29:55,530 Sub-title censored. 1082 01:30:09,193 --> 01:30:13,366 Chairman of the Investigative Committee on Minors in Sects. 1083 01:30:13,530 --> 01:30:17,205 Chairman of the French-Tunisian Friendship Association. 1084 01:30:17,671 --> 01:30:18,678 - Yes? - Yes. 1085 01:30:18,743 --> 01:30:19,452 Yeah. 1086 01:30:20,458 --> 01:30:21,842 So… 1087 01:30:22,585 --> 01:30:24,003 Gerard Bapt. 1088 01:30:25,186 --> 01:30:26,764 Gerard Bapt… so... 1089 01:30:26,983 --> 01:30:30,343 Gerard Bapt, member of the Socialist Party and heart specialist. 1090 01:30:30,551 --> 01:30:33,679 M.P. for the 2nd District of Haute-Garonne since... 1091 01:30:33,864 --> 01:30:34,906 Mum... I'm hungry! 1092 01:30:34,931 --> 01:30:36,553 Five minutes, sweetie. 1093 01:30:37,257 --> 01:30:39,531 I'm going to have a hypoglycemia attack! 1094 01:30:39,556 --> 01:30:40,827 The article's tops! 1095 01:30:41,104 --> 01:30:43,231 The photograph, though… 1096 01:30:43,439 --> 01:30:45,525 - Not very inviting. - I'm not a model. 1097 01:30:47,985 --> 01:30:50,029 Wow, you look ugly. 1098 01:30:50,788 --> 01:30:52,215 Looks like Auntie Greta. 1099 01:30:53,199 --> 01:30:54,784 People will be stoning you. 1100 01:30:54,992 --> 01:30:56,661 This article will really stir things up. 1101 01:30:56,869 --> 01:30:59,514 If I saw that face there, I wouldn't want to read it. 1102 01:31:01,678 --> 01:31:03,788 Arnaud? Hold it closer to you. 1103 01:31:05,128 --> 01:31:07,213 Not too much… You're angry! 1104 01:31:07,428 --> 01:31:09,474 It has to show, anyway! 1105 01:31:09,913 --> 01:31:11,509 - Not too much. - We say "no"! 1106 01:31:11,717 --> 01:31:12,835 Truth will out! 1107 01:31:15,486 --> 01:31:16,613 Don't move. 1108 01:31:17,056 --> 01:31:18,933 It's good when she shakes it! 1109 01:31:24,188 --> 01:31:26,023 - Better expression. - I like that one. 1110 01:31:26,232 --> 01:31:27,775 Oh, you're so cute! 1111 01:31:28,025 --> 01:31:29,110 Will that do it? 1112 01:31:29,318 --> 01:31:31,585 - You look like a kitten. - You're all nuts. 1113 01:31:33,197 --> 01:31:35,967 Looking determined, but gentle… 1114 01:31:43,749 --> 01:31:45,126 That's great! 1115 01:31:45,877 --> 01:31:48,963 It's great! You look lovely. Stop laughing! 1116 01:31:49,172 --> 01:31:50,991 Seriously, Mum... 1117 01:31:51,924 --> 01:31:53,050 That looks great. 1118 01:31:53,259 --> 01:31:54,677 She'd going to look really good. 1119 01:31:55,344 --> 01:31:56,429 Smile. 1120 01:31:57,722 --> 01:31:59,182 That's perfect. 1121 01:32:00,933 --> 01:32:02,101 Jacky Henin. 1122 01:32:02,810 --> 01:32:05,696 H, E acute, N, I, N. 1123 01:32:07,106 --> 01:32:08,482 Jacky and Michel. 1124 01:32:09,525 --> 01:32:12,743 - Eva Joly. J, O, L, Y. 1125 01:32:13,279 --> 01:32:14,688 This Irene Frachon again... 1126 01:32:14,772 --> 01:32:18,173 The pulmonologist who sent you the book about Mediator. 1127 01:32:18,618 --> 01:32:21,204 Sorry to bombard you with these messages... 1128 01:32:21,344 --> 01:32:23,329 ...but I'd very much like to meet you. 1129 01:32:23,429 --> 01:32:26,584 Good afternoon, Sir. Irene Frachon, here. 1130 01:32:26,918 --> 01:32:30,630 We never seem to catch each other. I had a patient. 1131 01:32:30,838 --> 01:32:35,468 I thought this might be a subject of great interest to your magazine. 1132 01:32:35,676 --> 01:32:36,886 It's not all in my book. 1133 01:32:37,094 --> 01:32:39,055 Feel free to call me day or night. 1134 01:32:39,263 --> 01:32:42,350 I hope you've received it and maybe have read it. 1135 01:32:42,558 --> 01:32:45,811 To put it all succinctly… 1136 01:32:46,395 --> 01:32:48,022 ...it's a national scandal. 1137 01:33:03,051 --> 01:33:08,238 A few more balls to exchange. Which referee to ask the score? It's worse than I thought. 1138 01:33:30,415 --> 01:33:33,119 Thesis for Doctorate of Pharmacology 1139 01:33:41,031 --> 01:33:43,031 National Assembly 1140 01:33:43,869 --> 01:33:45,683 - Gerard Bapt? - Irene Frachon. 1141 01:33:45,830 --> 01:33:47,433 Delighted to meet you. 1142 01:33:58,509 --> 01:34:02,346 I'll ask you the unanswered question... how many killed? 1143 01:34:03,556 --> 01:34:05,554 Deaths that can really be proven. 1144 01:34:09,020 --> 01:34:12,289 How many deaths do you need, in order to be interested? 1145 01:34:12,414 --> 01:34:14,375 I've held one of them in my arms.. 1146 01:34:14,820 --> 01:34:17,062 . and as far as I'm concerned, one is enough. 1147 01:34:17,718 --> 01:34:20,297 Get off your high horse, or you'll get nowhere. 1148 01:34:22,772 --> 01:34:23,523 What? 1149 01:34:24,201 --> 01:34:26,287 I read your unbearable book, I'm sorry to say. 1150 01:34:26,495 --> 01:34:29,437 Probably the only Paris journalist who did. 1151 01:34:29,999 --> 01:34:33,377 You flood my answering-machine with your messages of doom... 1152 01:34:33,679 --> 01:34:36,507 I guess you want more than a footnote from me. 1153 01:34:37,506 --> 01:34:40,437 For an hour now, you've hit me with stories… 1154 01:34:40,634 --> 01:34:42,828 ...of poisoned valves, case-control patients... 1155 01:34:42,906 --> 01:34:44,742 Turn-offs like I've never seen. 1156 01:34:45,242 --> 01:34:46,747 I write for Le Figaro. 1157 01:34:46,772 --> 01:34:49,781 If I get anything more, I'm going home to bed. 1158 01:34:56,192 --> 01:34:58,569 It's difficult to know exactly. 1159 01:34:59,297 --> 01:35:05,409 A student has calculated a figure for her thesis on Mediator, but… 1160 01:35:06,619 --> 01:35:08,079 ...it remains to be verified. 1161 01:35:13,584 --> 01:35:14,523 - 500 ? 1162 01:35:16,879 --> 01:35:18,312 It remains to be verified. 1163 01:35:32,031 --> 01:35:33,646 Dear Doctor... 1164 01:35:35,242 --> 01:35:39,902 I now understand, thanks to you, why there are so many things I can no longer do. 1165 01:35:40,718 --> 01:35:45,375 Look after my grand-kids, do little jobs, walk more that 150 metres... 1166 01:35:45,609 --> 01:35:50,187 I do not believe doctors any more, we cannot trust them anymore. 1167 01:35:51,070 --> 01:35:52,706 Happily, people like you… 1168 01:35:52,915 --> 01:35:54,041 Look at this. 1169 01:35:54,867 --> 01:35:57,132 From every corner of France. 1170 01:35:57,586 --> 01:35:59,296 We were right, damn it! 1171 01:35:59,505 --> 01:36:01,465 "Why not a Breton gene?" he said. 1172 01:36:02,628 --> 01:36:07,382 This woman lost her sister who wanted to come in her wedding dress. 1173 01:36:08,170 --> 01:36:09,656 Here's the photo. 1174 01:36:14,437 --> 01:36:15,976 Why didn't you tell me? 1175 01:36:17,566 --> 01:36:18,750 Didn't tell you? 1176 01:36:18,941 --> 01:36:20,359 About what? 1177 01:36:20,568 --> 01:36:22,611 Flore Michelet's thesis. 1178 01:36:23,154 --> 01:36:24,250 What about it? 1179 01:36:26,615 --> 01:36:30,661 When are you going to stop treating me like your pet nerd on your leash? 1180 01:36:31,954 --> 01:36:33,750 Antoine, what is it you… 1181 01:36:34,290 --> 01:36:37,218 You knew I'd advised her against touching that. 1182 01:36:38,502 --> 01:36:42,070 But you're paranoid. How would I know? 1183 01:36:42,423 --> 01:36:44,382 She was the one who came to see me. 1184 01:36:44,539 --> 01:36:46,805 The pharmas are her future employers. 1185 01:36:46,969 --> 01:36:50,014 Meanwhile she graduated with flying colours. 1186 01:36:50,222 --> 01:36:52,133 This is your personal crusade. 1187 01:36:53,934 --> 01:36:56,395 You ignore the consequences it might have for others, eh? 1188 01:37:13,454 --> 01:37:15,383 Has Inserm dumped you? 1189 01:37:17,917 --> 01:37:19,460 Yeah. Heavily. 1190 01:37:21,618 --> 01:37:25,102 Has the academic committee been infiltrated by pharmas? 1191 01:37:32,097 --> 01:37:34,850 I've hunted Inserm certification for ten years. 1192 01:37:35,392 --> 01:37:37,561 And there's a whole team behind me. 1193 01:37:38,270 --> 01:37:40,805 I've lost all my research credits. All of them! 1194 01:37:41,899 --> 01:37:43,567 It's over for me here. 1195 01:37:43,985 --> 01:37:45,625 I'm going to try Canada. 1196 01:37:48,322 --> 01:37:52,048 I'm truly sorry, Antoine, I don't know what to say. 1197 01:37:52,409 --> 01:37:53,827 Best you say nothing. 1198 01:37:54,787 --> 01:37:56,705 Just get out of my life. 1199 01:38:41,625 --> 01:38:42,989 Anne Jouan. Want it? 1200 01:38:43,207 --> 01:38:43,950 No. 1201 01:38:44,044 --> 01:38:46,213 Isn't it the journalist who was helping you? 1202 01:38:46,340 --> 01:38:47,723 Samuel, I said "no". 1203 01:38:50,551 --> 01:38:54,434 Shortness of breath may be due many things... 1204 01:38:54,786 --> 01:38:56,293 There's smoking… 1205 01:38:56,432 --> 01:38:59,560 I'm not out of breath at all... My doctor heard... 1206 01:38:59,768 --> 01:39:01,395 Yes... it's whistling a bit. 1207 01:39:01,606 --> 01:39:03,397 Sometimes it whistles. 1208 01:39:03,723 --> 01:39:06,650 You've got ticklish bronchi, I'd say. 1209 01:39:06,859 --> 01:39:07,776 Alright? 1210 01:39:08,152 --> 01:39:10,946 When you have an asthma attack it goes like that... 1211 01:39:11,309 --> 01:39:12,740 The air doesn't come in anymore. 1212 01:39:13,004 --> 01:39:14,575 And with Ventolin, 1213 01:39:14,992 --> 01:39:16,076 ...it goes like that... 1214 01:39:16,285 --> 01:39:17,745 Then I can breathe. 1215 01:39:17,953 --> 01:39:20,106 You can breathe and you can do everything. 1216 01:39:20,278 --> 01:39:23,809 You can even take her to the playground, carefully. 1217 01:39:25,544 --> 01:39:26,420 Well what? 1218 01:39:26,809 --> 01:39:28,020 I have bronchitis. 1219 01:39:28,464 --> 01:39:29,653 I have a scoop. 1220 01:39:29,871 --> 01:39:30,840 Oh yeah? 1221 01:39:31,050 --> 01:39:33,761 AFSSAPS have asked CNAM to count the number of deaths. 1222 01:39:34,168 --> 01:39:35,278 They're freaking out. 1223 01:39:35,614 --> 01:39:37,973 Flore's estimate has leaked... They want to demolish you. 1224 01:39:38,182 --> 01:39:39,778 Who's told you this? 1225 01:39:39,942 --> 01:39:41,278 I don't reveal my sources. 1226 01:39:41,442 --> 01:39:44,793 I have a contact at CNAM... who works for us. 1227 01:39:44,897 --> 01:39:46,364 A mole, it's called. 1228 01:39:46,482 --> 01:39:49,239 It's been radio silence with him for a while. 1229 01:39:50,020 --> 01:39:51,762 I was able to get onto his wife. 1230 01:39:52,196 --> 01:39:54,278 I asked if her husband was well. 1231 01:39:55,240 --> 01:39:56,450 She said... 1232 01:39:57,117 --> 01:39:59,637 "He knows what he has to do." and hung up. 1233 01:40:02,331 --> 01:40:04,917 What if he's the one that AFSSAPS are using? 1234 01:40:05,161 --> 01:40:07,528 He's probably scared stiff. 1235 01:40:10,047 --> 01:40:12,286 I received your request. 1236 01:40:12,966 --> 01:40:14,239 I'm not sure I understand. 1237 01:40:14,677 --> 01:40:19,442 You want me to evaluate the risk of valvulopathy in those on Mediator ? 1238 01:40:26,021 --> 01:40:28,856 Being essentially a calculation of the number of deaths. 1239 01:40:33,036 --> 01:40:35,168 Yes, that's something quite different. 1240 01:40:36,699 --> 01:40:41,286 You'll need to send me an e-mail stating precisely your requirements. 1241 01:40:41,453 --> 01:40:44,801 So we know what we're talking about and what we are looking for 1242 01:40:46,917 --> 01:40:48,832 As an indication, yes, obviously. 1243 01:40:49,348 --> 01:40:52,423 Nevertheless the calculations will be done by the book. 1244 01:40:53,799 --> 01:40:55,403 Numbers don't deviate. 1245 01:40:56,621 --> 01:40:57,996 That's what I like about them. 1246 01:41:11,332 --> 01:41:14,223 It's an essential dimension in terms of public health... 1247 01:41:15,223 --> 01:41:16,309 Irene! 1248 01:41:16,739 --> 01:41:17,740 What? 1249 01:41:18,004 --> 01:41:19,301 Your MP! 1250 01:41:19,676 --> 01:41:22,043 ...was banned in France only last November. 1251 01:41:23,137 --> 01:41:26,364 This molecule has been proscribed in the USA since 1996. 1252 01:41:26,947 --> 01:41:27,981 Your MP! 1253 01:41:28,167 --> 01:41:30,301 "My" MP?... I've seen him once. 1254 01:41:30,411 --> 01:41:32,254 The lung-doctor from Brest has sounded the alert... 1255 01:41:32,463 --> 01:41:34,598 ..and has done battle with the pharmaceutical company... 1256 01:41:34,840 --> 01:41:36,925 ...and with the health authorities... 1257 01:41:37,134 --> 01:41:39,825 ...to have the medication recalled. 1258 01:41:40,075 --> 01:41:45,184 I was thunderstruck to hear that her book title had been censored... 1259 01:41:45,601 --> 01:41:49,772 Because it posed the the question the company disliked so much... 1260 01:41:49,987 --> 01:41:51,989 "Mediator, how many deaths?" 1261 01:41:52,801 --> 01:41:55,819 A question that the brilliant thesis... 1262 01:41:56,457 --> 01:41:57,801 How good is this! 1263 01:41:58,238 --> 01:42:00,082 It's good alright! 1264 01:42:04,129 --> 01:42:06,746 Are you afraid of pharmaceutical companies, Mrs Luciani? 1265 01:42:07,246 --> 01:42:10,501 How many deaths will it take to stop this insanity? 1266 01:42:10,709 --> 01:42:13,121 Institutions are not ones to be afraid. 1267 01:42:13,161 --> 01:42:16,465 Our decisions are only taken on a solid legal grounds... 1268 01:42:16,691 --> 01:42:20,402 ...so that they are in tune with the needs of public health. 1269 01:42:20,473 --> 01:42:22,746 Who do you want to protect, Madam? 1270 01:42:23,305 --> 01:42:25,418 The French people, or your government department? 1271 01:42:25,746 --> 01:42:28,393 I'll return to the subject without getting into controversy. 1272 01:42:30,437 --> 01:42:31,438 Yet once again... 1273 01:42:31,647 --> 01:42:33,232 ...I'm trying to get back to the issue. 1274 01:42:34,567 --> 01:42:36,114 You're on the wrong side! 1275 01:42:36,151 --> 01:42:39,153 … a decision that's fraught with consequences… 1276 01:42:39,341 --> 01:42:41,208 Fraught with consequences for whom? 1277 01:42:41,615 --> 01:42:43,116 The pharmaceutical company! 1278 01:42:44,083 --> 01:42:46,771 It wasn't the evidence that was weak, it was you!. 1279 01:42:47,013 --> 01:42:49,790 You, who are supposed to defend the interests of the sick... 1280 01:42:49,998 --> 01:42:51,810 ...but instead shut your eyes... 1281 01:42:52,084 --> 01:42:56,372 ...on the criminal acts of a pharma, with total cynicism. 1282 01:42:56,833 --> 01:42:59,550 You can't be policeman and gangster at the same time, madam. 1283 01:42:59,765 --> 01:43:01,183 You have to pick a side. 1284 01:43:01,385 --> 01:43:03,341 Stop... Sam's going to be sick. 1285 01:43:03,833 --> 01:43:08,927 Each time Irene Frachon was met with distrust, it's amazing. 1286 01:43:09,226 --> 01:43:11,353 No... if you'll allow me... 1287 01:43:11,562 --> 01:43:14,161 That's just her emotional interpretation. 1288 01:43:14,357 --> 01:43:16,191 You don't agree? 1289 01:43:16,400 --> 01:43:19,486 Once again, I'm here to contextualize... 1290 01:43:19,695 --> 01:43:22,531 ...not to revisit the emotional and subjective... 1291 01:43:22,739 --> 01:43:25,474 ...interpretations of Mrs Frachon. 1292 01:43:25,818 --> 01:43:28,829 We obviously see things very differently. 1293 01:43:29,037 --> 01:43:32,207 Why don't you come and see a victim of Mediator at the morgue... 1294 01:43:32,439 --> 01:43:34,856 ..and then go and explain to her children... 1295 01:43:34,960 --> 01:43:36,529 ...and her husband... 1296 01:43:36,670 --> 01:43:38,716 ...the importance of contextualisation. 1297 01:43:39,548 --> 01:43:41,967 Thank you, Irene Frachon and thank you, Mrs Luciani. 1298 01:43:42,175 --> 01:43:44,575 A very polarised debate as we have seen. 1299 01:43:44,630 --> 01:43:45,646 Goodbye. 1300 01:43:46,075 --> 01:43:47,411 What a stupid cow! 1301 01:43:48,515 --> 01:43:50,115 Did you hear her? 1302 01:43:50,475 --> 01:43:51,768 That bitch?! 1303 01:44:05,616 --> 01:44:09,091 This could go on for a long time, Mr Jaffredo. 1304 01:44:10,037 --> 01:44:11,240 It could be… 1305 01:44:12,091 --> 01:44:13,295 ...5 or 6 years. 1306 01:44:13,999 --> 01:44:16,001 With chances to succeed still? 1307 01:44:16,752 --> 01:44:18,170 What are the chances? 1308 01:44:19,504 --> 01:44:21,388 The chances depend on the medical report. 1309 01:44:21,982 --> 01:44:23,779 A very thorough medical report. 1310 01:44:24,419 --> 01:44:25,544 Extremely thorough. 1311 01:44:26,428 --> 01:44:28,639 My heart's opened up anyway. 1312 01:44:28,847 --> 01:44:29,514 Yes. 1313 01:44:34,770 --> 01:44:36,229 I wish that... 1314 01:44:36,841 --> 01:44:39,669 ...everyone who took this human time bomb... 1315 01:45:07,966 --> 01:45:10,472 Corinne's ultra-sounds were done here, right? 1316 01:45:10,681 --> 01:45:11,473 Yes. 1317 01:45:13,976 --> 01:45:16,228 And this is the pair that started it all. 1318 01:45:18,670 --> 01:45:19,963 I'd've got nowhere without him. 1319 01:45:20,124 --> 01:45:21,960 I didn't do so much. 1320 01:45:24,277 --> 01:45:26,446 He seems a bit awkward, but ... 1321 01:45:27,593 --> 01:45:31,421 Here we have my manager, Laugier, who really saved the day. 1322 01:45:35,382 --> 01:45:37,531 Here's two more of the gang! 1323 01:45:41,420 --> 01:45:42,796 Professor Le Bihan... 1324 01:45:43,734 --> 01:45:45,843 Patricia Brize, a member of the team. 1325 01:45:46,550 --> 01:45:49,296 Mr Oudin will be defending the victims in court. 1326 01:45:49,553 --> 01:45:50,820 Pleased to meet you. 1327 01:45:53,348 --> 01:45:54,890 Are we still having lunch? 1328 01:45:59,241 --> 01:46:00,147 Laugier! 1329 01:46:00,522 --> 01:46:01,815 - What? - Laugier. 1330 01:46:24,836 --> 01:46:27,695 MEDIATOR HEART-VALVE DEATHS 1331 01:46:28,054 --> 01:46:29,327 That was quick. 1332 01:46:29,885 --> 01:46:33,221 I thought it was a matter of urgency. 1333 01:46:36,850 --> 01:46:38,390 So... the number? 1334 01:46:40,353 --> 01:46:41,438 Page 4. 1335 01:46:57,496 --> 01:47:01,291 They're reluctant to publish the article without the CNAM number. 1336 01:47:01,507 --> 01:47:04,909 But three of my sources have read it. I'm sure of it. 1337 01:47:04,968 --> 01:47:06,678 What are they afraid of? 1338 01:47:06,880 --> 01:47:08,449 Fake numbers that will screw us up. 1339 01:47:08,605 --> 01:47:10,770 What if I get kicked off this paper. 1340 01:47:10,842 --> 01:47:12,597 "Much obliged, Franchon!" 1341 01:47:12,769 --> 01:47:18,144 If it's all correct, they'll be hell-bent on grabbing the story. 1342 01:47:18,892 --> 01:47:20,472 Be sure I can reach you around 7.30 1343 01:47:29,878 --> 01:47:32,114 Why toot!? 1344 01:47:32,322 --> 01:47:34,269 Everyone's aggressive tonight. 1345 01:47:35,826 --> 01:47:38,078 Go on! 1346 01:47:42,566 --> 01:47:43,792 2 minutes until the bomb drops. 1347 01:47:44,000 --> 01:47:44,960 Really? 1348 01:47:49,381 --> 01:47:50,924 Is it still happening? 1349 01:47:51,699 --> 01:47:53,527 Approved, but hasn't gone to press yet. 1350 01:47:53,628 --> 01:47:55,542 Let's hope it's not pulled. 1351 01:47:55,569 --> 01:47:58,160 What I wouldn't give for a stiff drink! 1352 01:48:02,573 --> 01:48:04,128 Hiroshima, here we come! 1353 01:48:04,229 --> 01:48:06,542 Stop it! You're freaking me out! 1354 01:48:06,729 --> 01:48:08,721 This is no time for second thoughts. 1355 01:48:21,288 --> 01:48:23,039 Oh boy oh boy oh boy! 1356 01:48:23,248 --> 01:48:24,416 Anne, keep it down! 1357 01:48:24,624 --> 01:48:26,585 In six seconds it'll be on the web page. 1358 01:48:27,932 --> 01:48:28,879 Are you at home? 1359 01:48:28,924 --> 01:48:29,846 No! 1360 01:48:29,917 --> 01:48:31,346 Park and turn on the radio. 1361 01:48:31,463 --> 01:48:33,370 It'll be on all the 8 o'clock news flashes. 1362 01:48:34,741 --> 01:48:36,077 Oh boy oh boy! 1363 01:48:38,054 --> 01:48:39,431 Oh boy oh boy! 1364 01:48:55,912 --> 01:48:58,178 News on the Mediator story... 1365 01:48:58,265 --> 01:49:01,537 ...the medication that was withdrawn from sale in November. 1366 01:49:01,912 --> 01:49:04,936 A medication for overweight diabetics... 1367 01:49:05,107 --> 01:49:07,830 ...then prescribed for other patients wanting to lose weight. 1368 01:49:08,001 --> 01:49:10,086 When it was withdrawn from sale... 1369 01:49:10,295 --> 01:49:12,631 ...more than 300,000 people had been prescribed it 1370 01:49:12,839 --> 01:49:16,343 Mediator is accused of being a cause of death. 1371 01:49:16,551 --> 01:49:19,554 How many? An official report gives the figures. 1372 01:49:19,770 --> 01:49:22,017 Up until now we have only had estimates. 1373 01:49:22,057 --> 01:49:26,561 According to a secret CNAM study revealed by 'Le Figaro'... 1374 01:49:26,770 --> 01:49:30,667 ...Mediator was responsible for 500 to 1000 deaths in France... 1375 01:49:30,814 --> 01:49:33,267 ...due to heart-function complications. 1376 01:49:35,210 --> 01:49:37,629 ...having valvulopathy is not required... 1377 01:49:37,822 --> 01:49:38,949 ...but in case of doubt... 1378 01:49:39,157 --> 01:49:41,701 ...he will prescribe a cardiological consultation... 1379 01:49:41,910 --> 01:49:45,081 ...to be sure that you've not been affected. 1380 01:49:45,455 --> 01:49:48,458 ...Dr Frachon and the university team at Brest... 1381 01:49:48,667 --> 01:49:51,461 ...should be recognised for revealing these harmful effects. 1382 01:49:51,670 --> 01:49:54,464 We cannot forget that the government agency responsible... 1383 01:49:54,673 --> 01:49:57,384 ...worked to delay the withdrawal of Mediator from the market. 1384 01:49:57,592 --> 01:50:00,804 She had started to have signs of asthma... 1385 01:50:01,012 --> 01:50:04,128 ...later diagnosed as a valvulopathy. 1386 01:50:04,599 --> 01:50:06,839 She was dead 6 months later. 1387 01:50:22,167 --> 01:50:23,073 Yes? 1388 01:50:23,159 --> 01:50:25,912 Servier says these are figures from a thesis... 1389 01:50:26,129 --> 01:50:28,065 AFSSAPS says there were no deaths... 1390 01:50:28,123 --> 01:50:29,666 CNAM is ducking for cover. 1391 01:50:30,073 --> 01:50:31,557 They've got no balls. 1392 01:50:31,635 --> 01:50:33,159 We won't sell them ours. 1393 01:50:34,087 --> 01:50:36,881 I'll be getting on to Ms Luciani... 1394 01:50:37,090 --> 01:50:40,010 If anyone questions you, say no comment. 1395 01:50:40,218 --> 01:50:41,759 Protect yourself from attack. 1396 01:50:44,097 --> 01:50:46,736 Patoche, get yourself ready for a chaotic life. 1397 01:50:49,611 --> 01:50:52,415 Your article won't change anything. We aren't the only ones to refute. 1398 01:50:52,712 --> 01:50:55,314 Nobody believes your girl from Brest. 1399 01:50:55,692 --> 01:50:58,361 To base things on a doctoral thesis is quite dubious. 1400 01:50:59,095 --> 01:51:01,906 If even 'Figaro' is reducing it's rigour… 1401 01:51:02,115 --> 01:51:04,743 Our figures do not come from a thesis. 1402 01:51:04,954 --> 01:51:06,619 So where are they from? 1403 01:51:07,162 --> 01:51:08,454 They're from CNAM's study. 1404 01:51:09,142 --> 01:51:10,837 Still sure of no deaths? 1405 01:51:14,798 --> 01:51:16,408 I'm unaware of such a study. 1406 01:51:16,463 --> 01:51:18,704 Your office has had it since September 28. 1407 01:51:18,845 --> 01:51:21,400 Maybe you swept it under the carpet. 1408 01:51:23,178 --> 01:51:24,304 Listen… 1409 01:51:25,263 --> 01:51:29,431 There is one, but it still needs to be refined. 1410 01:51:29,689 --> 01:51:32,896 Refined how? We're talking about over 500 deaths, not a couple. 1411 01:51:34,220 --> 01:51:36,358 Irene Frachon... You wanted to speak to me? 1412 01:51:36,566 --> 01:51:39,402 What's it about? Let me write that down. 1413 01:51:39,720 --> 01:51:40,587 4pm. 1414 01:51:40,673 --> 01:51:42,155 She can't speak to you just now. 1415 01:51:42,364 --> 01:51:44,532 The toxicity has been known for 10 years. 1416 01:51:44,947 --> 01:51:48,275 Sorry... we're getting so many calls and I feel I'm drowning. 1417 01:51:48,759 --> 01:51:52,150 I do not agree with AFSSAPS' conclusions. 1418 01:51:52,999 --> 01:51:54,417 June 2006… 1419 01:51:56,477 --> 01:52:00,840 Mediator, is a drug in the same family as Isomeride which was withdrawn in 2007… 1420 01:52:08,932 --> 01:52:10,183 Irene Frachon... 1421 01:52:10,392 --> 01:52:13,686 ...when you talk about being pressured, what is it exactly? 1422 01:52:13,895 --> 01:52:18,566 Is it basically because the pharma is a French company? 1423 01:52:19,317 --> 01:52:23,931 The interests of big business and of the sick, are never to be confused. 1424 01:52:24,087 --> 01:52:26,783 There must be complete separation... 1425 01:52:27,227 --> 01:52:30,110 ...between those whose interests lie with the sick... 1426 01:52:30,196 --> 01:52:33,602 ...and the people negotiating with pharmaceutical companies. 1427 01:52:34,464 --> 01:52:36,524 Is she used to being in front of a camera? 1428 01:52:36,845 --> 01:52:39,212 No, she doesn't even have a TV at home. 1429 01:52:39,453 --> 01:52:42,203 ...you denounce the existing health links. 1430 01:52:42,259 --> 01:52:45,837 You're a lung specialist at the university hospital in Brest... 1431 01:52:46,056 --> 01:52:50,306 Are you aware that through this case you've became a whistle-blower? 1432 01:52:50,515 --> 01:52:53,587 I never set out to become one. 1433 01:52:54,060 --> 01:52:58,852 My vocation is to care for my patients as best I can. 1434 01:52:59,315 --> 01:53:03,040 I succeed, to varying degrees. But it is with them... 1435 01:53:03,403 --> 01:53:06,489 ...my patients... that my true interests lie. 1436 01:53:07,449 --> 01:53:10,535 In recent times, with the Mediator affair... 1437 01:53:10,743 --> 01:53:13,759 I can declare the links that I have with... 1438 01:53:14,247 --> 01:53:17,970 I won't give their surnames, but it is important. 1439 01:53:20,420 --> 01:53:21,463 Joelle, 1440 01:53:21,963 --> 01:53:23,047 Anna, 1441 01:53:23,465 --> 01:53:24,591 Nicole, 1442 01:53:24,841 --> 01:53:25,884 Jacqueline, 1443 01:53:26,092 --> 01:53:26,926 Yvon, 1444 01:53:27,760 --> 01:53:28,761 Mireille, 1445 01:53:29,304 --> 01:53:30,388 Michel, 1446 01:53:30,680 --> 01:53:31,723 Monique, 1447 01:53:33,057 --> 01:53:34,267 Marie-Claude, 1448 01:53:35,185 --> 01:53:36,102 Yves, 1449 01:53:36,352 --> 01:53:37,520 Auguste, 1450 01:53:38,646 --> 01:53:39,522 Therese, 1451 01:53:40,315 --> 01:53:41,357 Renee, 1452 01:53:42,981 --> 01:53:44,066 Corinne. 1453 01:53:46,462 --> 01:53:48,548 These are the people I know best. 1454 01:53:49,199 --> 01:53:51,023 Five of them are dead. 1455 01:53:52,202 --> 01:53:54,162 The others are in fear of dying. 1456 01:53:55,205 --> 01:53:57,313 Somebody has to look after them. 1457 01:53:59,056 --> 01:54:02,157 - That went so well! - She's just so calm! 1458 01:54:02,337 --> 01:54:03,970 Are the Beatles here, or something? 1459 01:54:04,204 --> 01:54:05,089 There she is! 1460 01:54:11,846 --> 01:54:14,849 Are you now more convinced that this medication kills? 1461 01:54:15,058 --> 01:54:17,915 I've been sure of it for quite a while now... 1462 01:54:18,561 --> 01:54:21,118 ...since I saw the first case... 1463 01:54:21,523 --> 01:54:25,109 ...an extremely serious heart-valve case, in 2008. 1464 01:54:25,944 --> 01:54:28,530 When your book came out, nobody wanted to listen. 1465 01:54:28,738 --> 01:54:30,949 People doubted your propositions. 1466 01:54:31,157 --> 01:54:33,660 Is that situation reversed now? 1467 01:54:33,868 --> 01:54:35,119 Yes, but… 1468 01:54:35,391 --> 01:54:38,797 It's all been tipped completely, but... 1469 01:54:38,998 --> 01:54:42,627 ...only after a proven major public health issue... 1470 01:54:42,835 --> 01:54:44,587 ...had been rejected by the authorities... 1471 01:54:44,796 --> 01:54:47,757 ...who shut their eyes and ears to the catastrophe. 1472 01:54:47,966 --> 01:54:50,343 What do you expect Servier to do next? 1473 01:54:50,552 --> 01:54:54,013 This company, past masters in driving people insane... 1474 01:54:54,222 --> 01:54:57,767 ...and getting feedback from my patients on their evaluations... 1475 01:54:57,976 --> 01:55:00,936 ...are going to act like a rapist, saying they were willing... 1476 01:55:01,014 --> 01:55:02,405 The girl from Brest? 1477 01:55:02,446 --> 01:55:04,764 ...and accusing the victim of asking for it. 1478 01:55:04,816 --> 01:55:07,986 Will the scandal be as serious as that of the contaminated blood? 1479 01:55:08,108 --> 01:55:10,327 There were refusals to listen to you? 1480 01:55:10,947 --> 01:55:12,907 Refusals to listen to me? Yes! 1481 01:55:13,408 --> 01:55:19,122 I felt I was made to feel unwelcome before I'd opened my mouth. 1482 01:55:19,330 --> 01:55:20,790 That was a problem. 1483 01:55:20,999 --> 01:55:25,085 And then, various pressures, certainly. 1484 01:55:25,253 --> 01:55:27,380 It was very disagreeable. 1485 01:55:28,006 --> 01:55:30,633 My work was greatly denigrated. 1486 01:55:30,842 --> 01:55:33,261 You said that you've been afraid. 1487 01:55:33,469 --> 01:55:34,512 Yes. 1488 01:55:35,388 --> 01:55:36,913 I HAVE been afraid. 1489 01:55:41,367 --> 01:55:44,038 Ministry of Health January 15 1490 01:56:00,538 --> 01:56:02,248 I.D.? 1491 01:56:02,749 --> 01:56:04,030 Show yours. 1492 01:56:04,834 --> 01:56:06,116 Show me your card. 1493 01:56:07,629 --> 01:56:08,630 Irene? 1494 01:56:08,963 --> 01:56:09,881 Yes? 1495 01:56:12,884 --> 01:56:14,522 I'm Arsene Weber. 1496 01:56:15,511 --> 01:56:17,163 My Santa Claus! 1497 01:56:22,185 --> 01:56:23,991 I'm so glad to meet you. 1498 01:56:24,077 --> 01:56:25,188 Me too. 1499 01:56:27,315 --> 01:56:28,900 Know him? No. 1500 01:56:38,368 --> 01:56:41,944 Now that its work is done the Commission... 1501 01:56:42,455 --> 01:56:43,542 ...before presenting… 1502 01:56:44,030 --> 01:56:45,725 Minister... please! 1503 01:56:47,126 --> 01:56:51,673 ...wants to highlight the major elements, the important points in this report. 1504 01:56:53,257 --> 01:56:56,358 The course of events reported in this report... 1505 01:56:56,844 --> 01:57:02,058 ...is largely related to the behavior and strategy of Servier Laboratories... 1506 01:57:03,434 --> 01:57:06,354 ...who, for 35 years, have played with the lives... 1507 01:57:06,562 --> 01:57:09,232 ...of those involved in this chain of events... 1508 01:57:09,969 --> 01:57:12,430 ...in order to continue marketing... 1509 01:57:12,568 --> 01:57:14,116 ...Mediator, and have it recognised... 1510 01:57:14,342 --> 01:57:17,647 ...in the treatment of diabetes. 1511 01:57:18,874 --> 01:57:23,975 To use an expression one often sees in the testimony we have gathered... 1512 01:57:25,812 --> 01:57:27,163 ...this company... 1513 01:57:27,381 --> 01:57:32,163 ...this firm did not just anesthetize those involved... 1514 01:57:32,672 --> 01:57:35,186 ...it lied to them. 1515 01:57:38,136 --> 01:57:41,806 The commission has been informed of the pressures... 1516 01:57:42,170 --> 01:57:45,256 ...exercised by people from Servier... 1517 01:57:45,601 --> 01:57:47,687 ...or others with special interests... 1518 01:57:47,895 --> 01:57:52,108 ...on those involved in proving the toxicity of Mediator. 1519 01:57:54,026 --> 01:57:56,988 The safety oversight body failed in its purpose... 1520 01:57:58,225 --> 01:58:00,366 ...which is to identify and instruct... 1521 01:58:00,928 --> 01:58:03,286 ...in a timely manner, and to illuminate... 1522 01:58:03,358 --> 01:58:04,912 ...the decision of those responsible... 1523 01:58:05,538 --> 01:58:07,874 ...in cases of serious side effects... 1524 01:58:08,082 --> 01:58:10,170 ...related to the use of the drug. 1525 01:58:10,960 --> 01:58:13,858 The main reason for this collective failure... 1526 01:58:14,505 --> 01:58:18,301 ...is to be found in the inadequacy of public health culture... 1527 01:58:18,982 --> 01:58:24,397 ...especially in a principle of letting precaution run backwards. 1528 01:58:25,683 --> 01:58:29,936 So, it's no wonder that this alert came from outside... 1529 01:58:30,605 --> 01:58:32,381 ...from the journal 'Prescribe'... 1530 01:58:33,030 --> 01:58:34,577 ...from Dr Irene Frachon... 1531 01:58:35,610 --> 01:58:38,405 ...Catherine Haynes, Dr Arsene Weber... 1532 01:58:38,624 --> 01:58:43,397 ...whose concern for the danger of this drug has resulted in its withdrawal. 1533 01:58:44,494 --> 01:58:47,622 As well as Flore Michelet and Dr Gerard Bapt... 1534 01:58:47,830 --> 01:58:51,209 ...regarding the impact in terms of mortality. 1535 01:58:53,516 --> 01:58:58,030 Their mission never lost sight of the dramatic human element... 1536 01:58:58,069 --> 01:59:00,936 ...of both the sick and the deceased. 1537 01:59:02,261 --> 01:59:05,678 They will be our guiding star in the upcoming debate. 1538 01:59:06,057 --> 01:59:07,058 Incredible! 1539 01:59:07,266 --> 01:59:12,104 Although the next phase will be defining and present guidelines... 1540 01:59:12,313 --> 01:59:15,107 ...for a reform of safety surveillance... 1541 01:59:16,192 --> 01:59:20,154 ...we wish to emphasize some of the most important lessons. 1542 01:59:38,422 --> 01:59:41,532 What do you think of the report's conclusions? 1543 01:59:42,058 --> 01:59:47,021 This is a great day for us, as finally it's all in black and white... 1544 01:59:47,223 --> 01:59:50,184 ...what we suspected, and sought to understand... 1545 01:59:50,393 --> 01:59:53,020 ...and it's all gone further than we could have imagined. 1546 01:59:54,021 --> 01:59:56,357 But what pressure, what influence... 1547 01:59:56,566 --> 01:59:58,818 ...what lobbying allowed, so many times... 1548 01:59:59,026 --> 02:00:02,903 ...in front of so many danger signals for a useless medication... 1549 02:00:02,989 --> 02:00:05,616 ...and I'm not alone in saying this... 1550 02:00:05,825 --> 02:00:07,827 ...to have all the warning lights switched off? 1551 02:00:11,247 --> 02:00:13,942 - Do you still smoke? - Oh yes. 1552 02:00:14,750 --> 02:00:16,252 But a lot less. 1553 02:01:01,589 --> 02:01:02,757 Cutie-pie! 1554 02:01:03,466 --> 02:01:05,146 The intrepid big-head! 1555 02:01:05,801 --> 02:01:07,450 Where are all of your photographers? 1556 02:01:12,058 --> 02:01:13,333 Going off on your own? 1557 02:01:13,726 --> 02:01:16,724 Gail and the kids are going to join me in a week. 1558 02:01:18,898 --> 02:01:22,193 I always hate saying au revoir, but… 1559 02:01:22,443 --> 02:01:24,481 I don't know, it's impossible... 1560 02:01:25,947 --> 02:01:26,989 ...to not say... 1561 02:01:27,198 --> 02:01:28,407 Limp dick? 1562 02:02:24,338 --> 02:02:26,057 Hello? Yes! 1563 02:02:28,228 --> 02:02:30,541 Thanks for calling back. You got my letter? 1564 02:02:30,886 --> 02:02:32,994 I have the paperwork in my car... 1565 02:02:33,283 --> 02:02:34,971 I'll call you back in minutes. 1566 02:02:36,517 --> 02:02:37,393 Yes. 1567 02:02:38,019 --> 02:02:40,847 They suffer a lot of physical, mental and economic needs... 1568 02:02:41,057 --> 02:02:42,690 ...and psychological... and material as well. 1569 02:02:42,898 --> 02:02:44,608 So that's it. 1570 02:02:45,192 --> 02:02:49,488 In private practice, it'll be head to head, with specialist fees up front. 1571 02:02:52,624 --> 02:02:54,410 That was the gist of my question. 1572 02:02:56,454 --> 02:02:59,832 We must find a quick way to compensate them. 1573 02:03:01,083 --> 02:03:03,377 I had the minister this morning and... 1574 02:03:05,254 --> 02:03:07,840 Yes, I'll send it straight away. 1575 02:03:08,049 --> 02:03:10,509 I'm nearly at my car. 1576 02:03:10,718 --> 02:03:12,386 Sure, sure. 1577 02:03:12,636 --> 02:03:13,846 Thanks a lot. 1578 02:03:14,208 --> 02:03:16,043 That's terrific, 1579 02:03:16,585 --> 02:03:18,184 Terrific. 1580 02:03:19,210 --> 02:03:20,436 I don't know what's happening to me. 1581 02:03:20,686 --> 02:03:22,646 No, I'm in a lift. 1582 02:03:22,855 --> 02:03:24,690 There, I'm going out of it. 1583 02:03:24,899 --> 02:03:28,819 Xavier Bertrand is hesitant about accepting a proposal from Servier... 1584 02:03:29,296 --> 02:03:32,907 ...which suggests setting up a compensation fund itself. 1585 02:03:33,282 --> 02:03:35,913 I have the first reports... they're chilling, sinister. 1586 02:03:36,265 --> 02:03:39,350 Antoine works in Canada, where he lives with his family. 1587 02:03:39,523 --> 02:03:42,569 He is still working together with the University of Brest. 1588 02:03:42,741 --> 02:03:45,530 The Mediator was judged in a civil court to be a defective product. 1589 02:03:45,679 --> 02:03:48,397 A criminal procedure is underway. No judgments have yet been issued. 1590 02:03:48,499 --> 02:03:51,241 July 29, 2011 a law passed current mediator victims. 1591 02:03:51,366 --> 02:03:54,061 On January 25, 2011, approved appeals court in Rennes... 1592 02:03:54,234 --> 02:03:57,108 Subtitle: "How many killed?" 1593 02:03:57,249 --> 02:03:59,999 AFSSAPS was reformed for increased security. 1594 02:04:00,023 --> 02:04:02,023 Two laws gave new administration and financing... 1595 02:04:02,047 --> 02:04:04,047 ...for increased transparency and enhanced ethics. 1596 02:04:07,594 --> 02:04:09,594 Subtitles by FatPlank for KG