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00:00:05,839 --> 00:00:08,042
♪ ♪
2
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(gunshot)
3
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(panting)
4
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Holmes!
5
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(gunshot)
6
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Sherlock!
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(gunshot)
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(gasps)
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(gasps)
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Holmes!
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You've had a knock
on the head, guv.
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WATSON: Sherlock! Holmes!
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Rest.
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Uh...
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(rhythmic beeping)
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I... I can't remember your name.
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Shinwell Johnson.
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What a ridiculous name.
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(laughs)
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So you've said, guv.
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You've had a traumatic
brain injury.
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I should go get your doctors.
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Wait.
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What happened to Holmes?
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I've been praying
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to whatever God would hear me
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that you'll wake up.
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And I've been dreading what
I'd have to say when you did.
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Three men went
over the waterfall.
30
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Yourself, Mr. Holmes
and the man we'd been chasing.
31
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James Moriarty.
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One survived.
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We've lost him, guv.
We've lost Mr. Holmes.
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I was trying to help him,
Shinwell.
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I went into the water after
to go get him.
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And I-I-I was close,
and I thought... Right.
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I thought I... Yeah. I know.
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You were the best friend
Mr. Holmes ever had.
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So don't you go punishing
yourself 'cause I won't have it.
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We will take time later,
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and we will remember
the man properly.
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But they're gonna want to have
a look inside your thick skull
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now you're up.
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Hey.
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Did you know that he was loaded?
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Holmes lived in
a two-bedroom flat
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on Baker Street.
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He might have been
quiet about it...
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but Holmes had the bees
and the honey
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to look after us both.
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Seems the man had a vision.
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Vision of you
practicing medicine again.
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He's funded a clinic
for you to run.
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You hire your choice of medics.
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There'll even be a certain...
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former hard man around
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to help you
look after the place.
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Former?
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You're in Sherlock's will?
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He's paying me
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to be your aide.
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(chuckles)
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Here.
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You're going home, guv.
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NURSE: There she is.
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Look how beautiful.
(heart beating on Doppler)
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Huh. (Inhales sharply)
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How are you, darling?
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Just haven't really been...
sleeping.
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I bet people say, "You need to
relax," when you tell them that?
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(inhales and exhales heavily)
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(fetal heartbeat distorting)
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(gasps)
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Are you okay, hon?
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Did you see that?
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(voice distorting):
What is it, honey?
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(groans) I...
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I have to... I'm good.
I have to... Erika?
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(grunting)
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Are you all right?
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(voice distorting):
Miss Filipello?
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(gasps) (car horn blaring)
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(tires screech)
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(screams)
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Don't move. I'm gonna
call for help. Ambulance.
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Call an ambulance!
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(elevator bell dings)
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♪ ♪
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It's past 8:00.
Good morning, Dr. Derian.
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It's Tuesday, September 24.
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My name remains
John Hamish Watson.
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It would be my pleasure to
repeat any ten words you'd like.
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You should let me
ask the questions
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before you answer them.
Good morning, Shinwell.
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Good morning, Dr. Watson.
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Your young doctors need tending.
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Yes, I've noticed.
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You should let me
ask the questions
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before you answer them.
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11 words, by the way.
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Watson, we seriously need
another centrifuge
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if you want us
to log this many genomes.
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It's the best lab
in the country, Dr. Lubbock.
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I'm sure you'll figure it out.
105
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Good morning, Dr. Croft.
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We've got 200 patient
applications
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coming in every day.
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Can we see a patient from Malta?
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Of course we can.
Malta's an island.
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Good morning, Dr. Croft.
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I told him island populations
are fascinating.
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Well, keep at it.
Your brother can be stubborn.
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WATSON: I understand that, as
my neurologist, you're obligated
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to track my recovery,
but I'm fine.
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I've been fine for months.
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How are the headaches?
Manageable.
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Okay, any hyperventilation, sweating?
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Nope.
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What about the weeks
leading up to your injury?
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Still a blank?
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Mostly.
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I'm starting to...
remember things about him.
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"Him"? James Moriarty?
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I can see his hands.
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He has syndactyly.
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His second and third fingers
are fused.
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Almost like they make
the shape... of an "M."
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What?
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An archvillain named Moriarty
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whose hands make
the shape of an "M"?
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That sounds fictional.
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Did you ever see his face?
I don't know.
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Shinwell.
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I have a referral for you.
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I don't like this.
136
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Being your neurologist and
working for you at the clinic.
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I trained under Dr. Ishikato.
She's excellent.
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Oh, that's very nice,
but I already have
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the best neurologist
in the state... you, Dr. Derian.
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Cool flattery.
141
00:07:09,262 --> 00:07:11,031
You're still exploiting
an unbalanced power dynamic.
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I get nervous when young people
point words like that at me.
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Get another neurologist...
problem fixed.
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SHINWELL: Dr. Morstan
was asking for you on six.
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WATSON:
She has a scaphoid fracture
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and a compound break
to the tibia.
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It's a typical
post-accident trauma.
148
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Why are you filming her?
149
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Scroll ahead.
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She never fell asleep.
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00:07:33,887 --> 00:07:35,288
We admitted her two days ago,
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and she's been awake since then.
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She says it's been
seven days total.
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00:07:38,726 --> 00:07:40,561
Her name is Erika Filipello.
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00:07:40,661 --> 00:07:43,631
There's a family history
of fatal familial insomnia.
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00:07:43,731 --> 00:07:45,465
Oh, see, that's a snake pit.
157
00:07:45,599 --> 00:07:47,467
There's no test.
The only way to diagnose it is
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00:07:47,568 --> 00:07:49,369
to observe the progression
of her symptoms.
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00:07:49,469 --> 00:07:51,471
She needs someone
with your expertise.
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00:07:51,572 --> 00:07:54,508
Are you asking as
the medical director?
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00:07:54,608 --> 00:07:57,144
In what other capacity
would I be asking?
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Well, it's fair to say
that I owe you one.
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00:07:59,312 --> 00:08:01,715
I mean, I did leave home
for six months.
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00:08:01,815 --> 00:08:03,116
Couldn't call, couldn't write.
165
00:08:03,216 --> 00:08:04,752
I showed up at the bottom
of a waterfall.
166
00:08:04,852 --> 00:08:07,020
I forgive you for that, John.
Yes.
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00:08:07,120 --> 00:08:09,757
You forgave me all the way
to my own apartment.
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I'm asking
as the medical director.
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Got it. Okay. Well,
Mary, if she has FFI,
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she'll stay awake until
the proteins in her brain
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hollow out the thalamus, and
then, unfortunately, she'll die.
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00:08:22,435 --> 00:08:24,838
And she'll require medical care
the whole time.
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00:08:24,938 --> 00:08:26,373
She's already
having hallucinations.
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That's how she wound up here.
175
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Erika says her father died of
FFI in 2012. Oh, don't tell me.
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00:08:32,145 --> 00:08:33,947
I take my own histories.
It's the only way
177
00:08:34,047 --> 00:08:36,049
to avoid anchor bias and
start fresh. And start fresh.
178
00:08:36,183 --> 00:08:38,618
Yeah, so give me the
morning with her. Thank you.
179
00:08:38,619 --> 00:08:42,556
I'm, uh, finally
remodeling the garage.
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00:08:42,690 --> 00:08:44,191
I need you to get
your boxes out of there.
181
00:08:44,291 --> 00:08:45,993
Oh, you know what? I haven't
gotten a storage unit yet.
182
00:08:46,093 --> 00:08:48,127
Is that by design, John?
Search your soul.
183
00:08:48,128 --> 00:08:50,564
The boxes are not a beach head.
184
00:08:50,664 --> 00:08:52,132
I'm on it.
185
00:08:52,232 --> 00:08:53,400
Okay.
186
00:08:53,500 --> 00:08:55,068
You've been rehabbing
for six months.
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00:08:55,202 --> 00:08:57,537
The clinic's been open for two.
188
00:09:00,440 --> 00:09:02,209
I'll check back in a bit.
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00:09:02,309 --> 00:09:04,311
(indistinct announcement
over P.A.)
190
00:09:04,411 --> 00:09:05,979
Good morning, Erika.
I'm Dr. Watson.
191
00:09:06,079 --> 00:09:08,548
I'm consulting on your case.
You're the specialist?
192
00:09:08,682 --> 00:09:10,584
Yes, I'm a clinical geneticist
and internist.
193
00:09:10,684 --> 00:09:13,887
I watched my father die
of FFI, Dr. Watson.
194
00:09:13,987 --> 00:09:15,455
It took my grandfather
before that,
195
00:09:15,555 --> 00:09:17,891
and I know it's going
to kill me, too.
196
00:09:18,726 --> 00:09:20,192
I don't think we're there yet.
197
00:09:20,193 --> 00:09:22,062
When someone starts
showing symptoms of FFI,
198
00:09:22,162 --> 00:09:24,231
they're typically dead
within three to eight months.
199
00:09:24,331 --> 00:09:25,665
And don't tell me
that I'm wrong,
200
00:09:25,666 --> 00:09:27,166
because it runs in my family,
201
00:09:27,167 --> 00:09:29,670
and I've been worried
about it my whole life.
202
00:09:29,770 --> 00:09:31,972
We have a job to do here.
203
00:09:33,073 --> 00:09:35,909
I'm... I'm five and a half
months pregnant,
204
00:09:36,009 --> 00:09:37,543
and I know...
205
00:09:37,544 --> 00:09:40,147
I know I'm going to die.
206
00:09:40,247 --> 00:09:42,983
I don't want this
baby to die, too.
207
00:09:43,984 --> 00:09:46,219
(breathing shakily)
208
00:09:46,319 --> 00:09:49,089
You're gonna manage my symptoms.
209
00:09:49,923 --> 00:09:52,192
Keep me alive until I can...
210
00:09:52,292 --> 00:09:56,096
deliver her... safely.
211
00:09:58,365 --> 00:10:00,533
♪ ♪
212
00:10:13,313 --> 00:10:16,383
You four are the smartest
doctors I could find.
213
00:10:16,483 --> 00:10:18,451
What does this family history
tell us?
214
00:10:18,551 --> 00:10:22,055
(Southern accent): A presumptive
diagnosis of fatal familial insomnia,
215
00:10:22,155 --> 00:10:23,590
which you've highlighted in red,
216
00:10:23,691 --> 00:10:26,193
shows up in every generation
of Erika's family.
217
00:10:26,326 --> 00:10:27,861
But the pattern's unusual.
218
00:10:27,961 --> 00:10:29,396
Her father's
one of six siblings,
219
00:10:29,496 --> 00:10:31,865
but he's the only one
to contract FFI.
220
00:10:31,999 --> 00:10:33,533
Are you nodding
221
00:10:33,667 --> 00:10:35,202
'cause you agree with me,
or are you trying
222
00:10:35,335 --> 00:10:37,070
to think of a way
to make fun of my accent?
223
00:10:37,170 --> 00:10:39,039
Bless your heart, Dr. Lubbock.
224
00:10:39,139 --> 00:10:40,373
(Southern accent):
I would never.
225
00:10:40,507 --> 00:10:42,509
FFI is autosomal dominant.
226
00:10:42,609 --> 00:10:44,678
You can only inherit the gene
from an affected parent.
227
00:10:44,778 --> 00:10:47,414
But if they had it, you got
a straight 50-50 shot.
228
00:10:47,514 --> 00:10:49,181
So, Erika's father
had five siblings,
229
00:10:49,182 --> 00:10:52,052
each with a 50% chance
of getting FFI.
230
00:10:52,152 --> 00:10:53,386
You flip a coin once,
231
00:10:53,520 --> 00:10:55,055
comes up heads for FFI.
232
00:10:55,155 --> 00:10:58,726
What are the odds that you flip
a coin five more times
233
00:10:58,859 --> 00:11:00,127
and it comes up tails?
234
00:11:00,227 --> 00:11:01,660
One-half to the power of five.
235
00:11:01,661 --> 00:11:03,731
A little better
than three percent.
236
00:11:03,831 --> 00:11:06,767
Are you saying you don't think
Erika's father had FFI?
237
00:11:06,900 --> 00:11:09,569
Whenever we take on a case,
we examine every assumption.
238
00:11:09,703 --> 00:11:10,938
We eliminate the impossible.
239
00:11:11,071 --> 00:11:12,539
Whatever remains,
however improbable...
240
00:11:12,639 --> 00:11:14,541
However improbable...
Must be the truth.
241
00:11:14,641 --> 00:11:16,409
WATSON: must be the truth.
242
00:11:16,509 --> 00:11:20,513
Erika's father took his own life
after the onset of his symptoms.
243
00:11:20,613 --> 00:11:22,950
He thought he inherited FFI.
He didn't want to die like that.
244
00:11:23,083 --> 00:11:26,018
His father died
from a car accident.
245
00:11:26,019 --> 00:11:29,256
There's no conclusive evidence
that Erika's father had FFI.
246
00:11:29,356 --> 00:11:31,224
And if he didn't have it,
she can't have it.
247
00:11:31,324 --> 00:11:33,360
Except that she reports
no sleep for seven days.
248
00:11:33,460 --> 00:11:34,661
WATSON:
Which could very well mean
249
00:11:34,762 --> 00:11:36,764
that she has
fatal familial insomnia
250
00:11:36,864 --> 00:11:40,600
or could mean that she's trapped
in a cycle of anxiety.
251
00:11:40,700 --> 00:11:41,700
ADAM: Anxiety?
252
00:11:41,701 --> 00:11:43,069
For seven nights in a row?
253
00:11:43,070 --> 00:11:44,271
STEPHENS: The mind is
a powerful thing, Adam.
254
00:11:44,404 --> 00:11:46,339
They've done studies
and everything.
255
00:11:46,439 --> 00:11:47,640
WATSON: You know, it
would've been easier
256
00:11:47,775 --> 00:11:49,276
to work with you two before Adam
257
00:11:49,376 --> 00:11:50,878
started dating your ex.
258
00:11:53,747 --> 00:11:54,948
He broke up with her years ago.
259
00:11:55,048 --> 00:11:56,316
A year ago.
260
00:11:56,416 --> 00:11:58,251
You still gave me your blessing.
261
00:11:58,351 --> 00:11:59,619
WATSON: Let's save the
tension for Thanksgiving.
262
00:11:59,753 --> 00:12:00,821
I'd like to offer
Erika Filipello
263
00:12:00,954 --> 00:12:03,490
something besides a slow death.
264
00:12:04,457 --> 00:12:06,493
We need to widen
our differential,
265
00:12:06,626 --> 00:12:10,263
see if she has
something other than FFI.
266
00:12:10,363 --> 00:12:12,665
Adam and Stephen... s.
267
00:12:12,766 --> 00:12:13,934
Stephens. My name is Stephens.
268
00:12:14,034 --> 00:12:15,302
WATSON: Yeah, I don't like it.
269
00:12:15,402 --> 00:12:16,402
Sounds like there's
more than one person
270
00:12:16,403 --> 00:12:17,637
named Stephen here.
271
00:12:17,737 --> 00:12:19,372
Crofts, go to Erika's house.
272
00:12:19,472 --> 00:12:20,940
Dig into her family history,
273
00:12:20,941 --> 00:12:23,376
see if you can bring us back
something interesting.
274
00:12:27,280 --> 00:12:30,017
Sasha, Ingrid, what tests
would you suggest we run?
275
00:12:30,117 --> 00:12:31,184
An MRI.
276
00:12:31,318 --> 00:12:33,320
Blood work to check
for a B12 deficiency.
277
00:12:33,420 --> 00:12:35,188
An FDG-PET to test
for a decrease
278
00:12:35,322 --> 00:12:37,289
in glucose utilization
in the thalamus.
279
00:12:37,290 --> 00:12:38,992
Off you go.
280
00:12:39,827 --> 00:12:43,462
MRS. FILIPELLO: My daughter
had a set of identical twins in her class.
281
00:12:43,463 --> 00:12:45,665
Zoey wore pink.
Emma wore purple.
282
00:12:45,765 --> 00:12:47,835
Maybe the two of yinz
can do something like that?
283
00:12:47,935 --> 00:12:50,037
Thank you, ma'am.
We'll look into that.
284
00:12:53,340 --> 00:12:55,876
When your husband got sick,
do you recall if a doctor
285
00:12:55,976 --> 00:12:57,443
ever treated it as FFI?
286
00:12:57,444 --> 00:12:59,046
Paul hated doctors.
287
00:12:59,179 --> 00:13:01,447
(wheezes) I think he went
twice before he just gave up.
288
00:13:01,448 --> 00:13:04,051
ADAM: It would also
help to track any changes
289
00:13:04,151 --> 00:13:05,784
to your daughter's diet,
her lifestyle.
290
00:13:05,785 --> 00:13:08,621
Are we talking about Paul,
or are we talking about Erika?
291
00:13:08,721 --> 00:13:10,858
Uh, we threw Erika
that pregnancy party.
292
00:13:10,991 --> 00:13:13,326
Let's stay focused on
Erika's father for the moment.
293
00:13:13,426 --> 00:13:14,862
What was unusual
about the party?
294
00:13:14,962 --> 00:13:17,230
Um, my mom and I made her
a plate of our deviled eggs.
295
00:13:17,330 --> 00:13:19,532
Erika ate the whole thing.
She had cravings.
296
00:13:19,632 --> 00:13:21,801
Oh. You're not Erika's sister?
297
00:13:21,902 --> 00:13:23,904
I'm her cousin. STEPHENS:
If we can get the names
298
00:13:24,004 --> 00:13:25,672
of those doctors... Does
Erika have a sensitivity
299
00:13:25,772 --> 00:13:27,374
to eggs? No.
300
00:13:27,474 --> 00:13:28,641
I'm sorry, Mrs. Filipello.
301
00:13:28,741 --> 00:13:29,742
My brother's
a functional medicine doctor.
302
00:13:29,877 --> 00:13:31,078
He thinks everything goes back
303
00:13:31,211 --> 00:13:32,579
to an egg sensitivity.
304
00:13:35,548 --> 00:13:36,884
(Mrs. Filipello cries)
305
00:13:38,919 --> 00:13:40,587
(Mrs. Filipello wheezes)
306
00:13:44,357 --> 00:13:46,826
I'm sorry, ma'am. We are...
307
00:13:46,927 --> 00:13:49,161
we are doing everything
we can to help Erika.
308
00:13:49,162 --> 00:13:52,031
Anything we might learn
about her father...
309
00:13:52,032 --> 00:13:54,935
contact information
for his doctors,
310
00:13:55,035 --> 00:13:58,004
old pictures, videos...
311
00:13:58,005 --> 00:13:59,973
anything might help.
312
00:14:02,609 --> 00:14:04,377
There's no harm
in being thorough.
313
00:14:04,477 --> 00:14:06,178
There's potential harm
in wasting time.
314
00:14:06,179 --> 00:14:09,216
Why go to medical school
if everything is a folk remedy?
315
00:14:09,316 --> 00:14:11,550
Why not get a certificate in...
316
00:14:11,551 --> 00:14:14,922
I don't know, Reiki massage
or angel readings or the moon?
317
00:14:15,956 --> 00:14:17,457
Certificate in the moon.
318
00:14:17,590 --> 00:14:19,859
Huh. (Mocking): "Huh."
319
00:14:19,960 --> 00:14:21,860
PAUL (on video):
So, down at that end...
320
00:14:21,861 --> 00:14:23,463
Huh. PAUL: It was this end.
321
00:14:23,563 --> 00:14:27,800
It was this end
where I scored the winning goal.
322
00:14:28,635 --> 00:14:31,537
These were all recorded within a
year of Paul Filipello's death.
323
00:14:31,538 --> 00:14:33,705
He looks like
he's walking like a...
324
00:14:33,706 --> 00:14:34,942
A chicken.
325
00:14:35,042 --> 00:14:36,408
Dystonic posture.
326
00:14:36,409 --> 00:14:38,278
Also known as a cock-walk.
327
00:14:38,411 --> 00:14:40,080
Was Erika's father
a steelworker?
328
00:14:40,180 --> 00:14:41,181
How'd you know that?
329
00:14:41,281 --> 00:14:42,282
WATSON: The cock-walk gait
330
00:14:42,415 --> 00:14:43,951
is consistent with manganism,
331
00:14:44,084 --> 00:14:45,652
a variety
of heavy metal poisoning
332
00:14:45,785 --> 00:14:47,820
seen most commonly in those
with consistent exposure
333
00:14:47,921 --> 00:14:49,156
to arc welding equipment.
334
00:14:49,256 --> 00:14:50,223
Dr. Derian,
335
00:14:50,323 --> 00:14:51,624
tell us a story
336
00:14:51,724 --> 00:14:53,293
about what might
have happened here.
337
00:14:53,393 --> 00:14:54,761
INGRID:
Paul Filipello gets sick.
338
00:14:54,861 --> 00:14:56,529
Some of the symptoms
of manganism overlap
339
00:14:56,629 --> 00:14:58,064
with symptoms of FFI.
340
00:14:58,065 --> 00:15:01,001
And worrying that he had FFI
interrupted his sleep patterns.
341
00:15:01,134 --> 00:15:03,236
When none of his doctors could
tell him what's wrong with him,
342
00:15:03,336 --> 00:15:04,904
Paul decides he has FFI
343
00:15:05,005 --> 00:15:06,506
and kills himself.
Compelling narrative.
344
00:15:06,606 --> 00:15:08,074
Tracks with what I'm observing.
345
00:15:08,075 --> 00:15:11,044
Let's agree amongst ourselves
that Erika Filipello's father
346
00:15:11,144 --> 00:15:12,845
didn't have FFI.
Therefore, neither does she.
347
00:15:12,946 --> 00:15:15,882
The chances are just too remote.
348
00:15:15,983 --> 00:15:17,817
I'm willing to exclude
the diagnosis.
349
00:15:17,917 --> 00:15:20,020
But where does that leave us?
STEPHENS: We still can't be sure
350
00:15:20,120 --> 00:15:21,854
if she's suffering from anxiety
351
00:15:21,989 --> 00:15:23,490
or if there's
an underlying condition.
352
00:15:23,590 --> 00:15:25,692
The only way to prove that
she doesn't have the disease
353
00:15:25,825 --> 00:15:27,460
is to help her fall asleep
and stay asleep.
354
00:15:27,560 --> 00:15:29,162
And if you're right,
the fact that she believes
355
00:15:29,296 --> 00:15:31,763
that she has it is exactly
what's keeping her awake.
356
00:15:31,764 --> 00:15:33,265
WATSON: There is...
357
00:15:33,266 --> 00:15:35,635
one thing we can do for her.
358
00:15:45,778 --> 00:15:47,814
(hard rock music playing):
♪ The enemy is everywhere ♪
359
00:15:47,914 --> 00:15:50,949
♪ No one seems
to be aware or care... ♪
360
00:15:50,950 --> 00:15:53,886
It's an interesting choice
for 10:00 p.m.
361
00:15:54,721 --> 00:15:56,589
Not like I'm gonna sleep.
362
00:15:57,490 --> 00:15:58,691
Here.
363
00:15:58,791 --> 00:16:00,260
You pick something.
364
00:16:01,694 --> 00:16:03,096
(song stops)
365
00:16:04,664 --> 00:16:08,268
("Avril 14th"
by Aphex Twin playing)
366
00:16:08,368 --> 00:16:09,569
So, I have some news.
367
00:16:09,669 --> 00:16:12,039
None of this has been written up
368
00:16:12,139 --> 00:16:14,173
in any medical journals yet.
369
00:16:14,174 --> 00:16:17,444
And very few people know
what I'm about to tell you.
370
00:16:20,613 --> 00:16:21,514
Dr. Morstan.
371
00:16:21,614 --> 00:16:23,515
Adam, right? Yeah.
372
00:16:23,516 --> 00:16:25,918
I'm here to check up
on Erika Filipello.
373
00:16:39,232 --> 00:16:40,666
WATSON: Some
research colleagues of mine
374
00:16:40,667 --> 00:16:44,771
have developed a test for FFI.
375
00:16:44,904 --> 00:16:48,241
It's as close to definitive
as these things get.
376
00:16:48,341 --> 00:16:49,942
I rushed your labs to her.
377
00:16:50,077 --> 00:16:51,009
Oh, my God.
378
00:16:51,010 --> 00:16:52,344
Erika, it's good news.
379
00:16:52,345 --> 00:16:54,247
You tested negative.
380
00:16:55,582 --> 00:16:57,683
You do not have FFI.
381
00:16:57,684 --> 00:16:58,851
(exhales)
382
00:16:58,951 --> 00:17:00,320
You may be sick
with something else.
383
00:17:00,420 --> 00:17:03,323
And if you are,
we will find out what that is.
384
00:17:04,624 --> 00:17:06,559
See if you can get
some sleep, okay?
385
00:17:09,162 --> 00:17:10,963
Dr. Watson.
386
00:17:11,064 --> 00:17:13,533
Would you stay with me
a little longer?
387
00:17:13,633 --> 00:17:15,468
(elevator bell dings)
388
00:17:15,568 --> 00:17:17,536
WATSON:
I left my life behind to...
389
00:17:17,537 --> 00:17:19,472
go solve mysteries in London.
390
00:17:19,606 --> 00:17:21,073
(both chuckle)
391
00:17:21,074 --> 00:17:23,643
Trust me, I wish
that was a joke.
392
00:17:23,776 --> 00:17:26,513
When I got back
from the war, I struggled.
393
00:17:26,613 --> 00:17:29,316
"The story of our lives
is written inside of us
394
00:17:29,449 --> 00:17:30,917
before we're ever born."
395
00:17:31,918 --> 00:17:33,953
My first genetics professor
said that.
396
00:17:34,053 --> 00:17:35,655
It's a hard way to live.
397
00:17:35,788 --> 00:17:38,091
Nothing really surprises you.
398
00:17:38,925 --> 00:17:41,027
Then I met someone
in London who...
399
00:17:41,794 --> 00:17:43,396
turned all of that
on its head.
400
00:17:43,496 --> 00:17:46,133
We became partners.
We were close friends.
401
00:17:48,968 --> 00:17:50,270
My wife...
402
00:17:51,971 --> 00:17:53,906
she saw that I...
403
00:17:54,006 --> 00:17:56,075
needed something,
whatever it was
404
00:17:56,176 --> 00:17:59,312
that I was getting out
of working with Holmes.
405
00:17:59,412 --> 00:18:00,579
And in the end,
406
00:18:00,580 --> 00:18:02,948
when the call came from Holmes,
407
00:18:02,949 --> 00:18:04,950
I picked him over Mary.
408
00:18:04,951 --> 00:18:06,786
Of course,
I didn't see it that way.
409
00:18:06,886 --> 00:18:09,455
I just thought, "One last case."
410
00:18:09,456 --> 00:18:12,325
But everything has
its breaking point, and...
411
00:18:12,459 --> 00:18:15,061
unfortunately, I found ours.
412
00:18:18,531 --> 00:18:19,966
And...
413
00:18:20,767 --> 00:18:22,635
when I was in that water...
414
00:18:23,836 --> 00:18:25,937
I thought I was about to die,
415
00:18:25,938 --> 00:18:28,508
my last thought
416
00:18:28,608 --> 00:18:31,244
before going over that fall
was...
417
00:18:32,712 --> 00:18:35,882
I'd never get a chance
to put it all back together.
418
00:18:38,851 --> 00:18:40,118
So...
419
00:18:40,119 --> 00:18:42,155
♪ ♪
420
00:18:58,070 --> 00:18:59,372
So you heard all that?
421
00:18:59,506 --> 00:19:02,542
Lying to patients is not
an ethical form of treatment.
422
00:19:02,675 --> 00:19:03,809
Not in my hospital.
423
00:19:03,810 --> 00:19:05,378
That's what you want
to talk about?
424
00:19:05,478 --> 00:19:06,579
Yes. Look, I am sorry
about almost everything,
425
00:19:06,679 --> 00:19:08,248
but I am not sorry about that.
426
00:19:08,381 --> 00:19:09,616
Look at the patient.
427
00:19:10,250 --> 00:19:11,451
I helped her.
428
00:19:16,122 --> 00:19:18,658
(birds chirping)
429
00:19:22,895 --> 00:19:24,864
Oh. Morning, darling.
How'd you sleep?
430
00:19:24,964 --> 00:19:26,533
Who is that?
431
00:19:26,633 --> 00:19:27,734
Dr. Lubbock.
432
00:19:27,834 --> 00:19:29,236
We've been taking shifts.
433
00:19:29,369 --> 00:19:30,937
(panting)
434
00:19:31,771 --> 00:19:33,406
Whoa, whoa. What's wrong? I-I...
435
00:19:33,540 --> 00:19:34,674
I can't see you.
436
00:19:34,774 --> 00:19:36,476
I-I can't see anything.
437
00:19:42,349 --> 00:19:44,551
(breathing heavily)
438
00:19:45,552 --> 00:19:47,354
WATSON: You're blind. (Gasps)
439
00:19:47,487 --> 00:19:49,289
I could've told you that.
440
00:19:49,389 --> 00:19:50,723
I needed you to show me.
441
00:19:50,823 --> 00:19:51,990
Dr. Watson,
442
00:19:51,991 --> 00:19:53,526
what's happening to me?
443
00:19:53,660 --> 00:19:54,927
It's a mystery, Erika.
444
00:19:55,027 --> 00:19:56,095
You're a mystery.
445
00:19:56,195 --> 00:19:58,531
I want you to do
something for me.
446
00:19:59,299 --> 00:20:01,468
It's the last thing you're
gonna want to do, but...
447
00:20:01,568 --> 00:20:02,669
try it anyway.
448
00:20:02,769 --> 00:20:04,237
Can you smile for me?
449
00:20:04,337 --> 00:20:05,504
You were married once.
450
00:20:05,505 --> 00:20:08,074
You know never to tell
a woman to smile.
451
00:20:08,207 --> 00:20:10,377
Not even if her
life depends on it?
452
00:20:12,178 --> 00:20:13,580
(hisses, groaning)
453
00:20:13,680 --> 00:20:14,847
It hurts.
454
00:20:14,947 --> 00:20:16,383
The sores around the
corner of your mouth...
455
00:20:16,483 --> 00:20:18,350
you have a condition
called angular cheilitis.
456
00:20:18,351 --> 00:20:19,985
Got worse overnight.
457
00:20:19,986 --> 00:20:21,321
What does that mean?
458
00:20:21,421 --> 00:20:22,489
SASHA: Is that...
459
00:20:22,589 --> 00:20:24,324
yeast?
460
00:20:24,424 --> 00:20:25,625
Erika Filipello has
a yeast infection.
461
00:20:25,725 --> 00:20:26,893
Around her mouth?
462
00:20:26,993 --> 00:20:27,960
A fungal infection
shouldn't cause
463
00:20:28,060 --> 00:20:29,329
angular cheilitis in someone
464
00:20:29,429 --> 00:20:31,831
with a healthy
and intact immune system.
465
00:20:31,931 --> 00:20:33,566
We may have a narrow window
to act here.
466
00:20:33,666 --> 00:20:35,033
Act on what?
467
00:20:35,034 --> 00:20:37,503
She's got a nonspecific
deficiency in her T and B cells.
468
00:20:37,504 --> 00:20:38,538
The tests,
469
00:20:38,638 --> 00:20:40,106
this infection...
470
00:20:40,206 --> 00:20:42,141
it's consistent with severe
combined immunodeficiency.
471
00:20:42,241 --> 00:20:44,876
SCID? "Boy in the
bubble" syndrome?
472
00:20:44,877 --> 00:20:47,814
We have to replace her faulty
immune system with a new one.
473
00:20:47,914 --> 00:20:49,482
INGRID: You want to give her
474
00:20:49,582 --> 00:20:51,083
a bone marrow transplant?
This is textbook overtreatment.
475
00:20:51,217 --> 00:20:53,219
Hire an immunologist,
get an immunodeficiency.
476
00:20:53,320 --> 00:20:56,255
(scoffs) A bone marrow
transplant has lifelong side effects.
477
00:20:56,356 --> 00:20:58,257
Erika Filipello was
fine a week ago.
478
00:20:58,391 --> 00:20:59,492
She's also pregnant.
479
00:20:59,592 --> 00:21:00,692
If I'm right and
we don't intervene,
480
00:21:00,693 --> 00:21:02,227
they'll both die.
481
00:21:02,228 --> 00:21:04,096
She is 23 weeks pregnant.
482
00:21:04,230 --> 00:21:06,032
The fetus is viable.
483
00:21:06,132 --> 00:21:07,133
Barely. Maybe.
484
00:21:07,266 --> 00:21:08,400
SASHA: If we deliver the baby
485
00:21:08,401 --> 00:21:09,701
and then we do the transplant,
486
00:21:09,702 --> 00:21:11,904
it has a small chance
of surviving.
487
00:21:14,541 --> 00:21:16,476
AUTOMATED VOICE: Caution.
WATSON: Pardon me.
488
00:21:16,609 --> 00:21:18,410
Proceed with caution.
489
00:21:18,411 --> 00:21:20,513
Anyone else worry
that LabGuardian 1881
490
00:21:20,613 --> 00:21:22,415
is gonna turn sentient
and kill us all?
491
00:21:22,515 --> 00:21:24,817
His name is Clyde, but we need
to find a bone marrow match
492
00:21:24,951 --> 00:21:26,919
before a transplant
is even viable.
493
00:21:27,019 --> 00:21:28,120
Erika's records
mention a brother.
494
00:21:28,220 --> 00:21:29,255
STEPHENS: Damon Filipello.
495
00:21:29,356 --> 00:21:30,990
He's been in and out of rehabs
496
00:21:31,123 --> 00:21:32,625
since their father died.
497
00:21:32,725 --> 00:21:34,026
No one knows where he is.
498
00:21:34,126 --> 00:21:35,995
Well, that's our best shot
at a match by far.
499
00:21:36,128 --> 00:21:37,129
We need to find him.
500
00:21:37,229 --> 00:21:38,631
Can Gregson help with that?
501
00:21:40,066 --> 00:21:42,469
Well, he does work
at Scotland Yard.
502
00:21:43,336 --> 00:21:45,171
Uh... (chuckles softly)
503
00:21:47,407 --> 00:21:50,577
You act like you never tracked
down a missing person before.
504
00:21:50,677 --> 00:21:52,011
We're doctors, not detectives.
505
00:21:52,111 --> 00:21:53,580
WATSON: Well, that's too bad,
506
00:21:53,680 --> 00:21:56,082
because right now,
your patient needs a detective.
507
00:21:56,182 --> 00:21:57,750
I'll work this on my end.
508
00:21:57,850 --> 00:22:00,653
You guys see what you can do
with finding Damon Filipello.
509
00:22:04,323 --> 00:22:06,826
Anybody know any bounty hunters?
510
00:22:06,926 --> 00:22:09,462
♪ ♪
511
00:22:10,830 --> 00:22:14,867
(laughs) Oh, it's a good bit
of crack, this, innit, eh?
512
00:22:14,967 --> 00:22:16,935
Running down a fugitive.
513
00:22:16,936 --> 00:22:18,771
Yeah, you miss it?
514
00:22:18,871 --> 00:22:20,840
You miss him?
515
00:22:23,643 --> 00:22:27,914
The world's less...
I don't know, bright
516
00:22:28,014 --> 00:22:30,216
without Sherlock Holmes in it.
517
00:22:30,349 --> 00:22:32,552
I reformed myself
'cause of Holmes.
518
00:22:32,685 --> 00:22:34,454
Shame. Yeah.
519
00:22:35,287 --> 00:22:36,856
I'll always mourn the man.
520
00:22:36,956 --> 00:22:39,125
But I'm grateful
you're still here.
521
00:22:39,892 --> 00:22:43,029
I suppose you could say
you're my Sherlock now.
522
00:22:46,699 --> 00:22:48,200
You know, I do miss that moment,
Shinwell.
523
00:22:48,300 --> 00:22:51,137
That moment when you helped
Holmes get to an answer
524
00:22:51,237 --> 00:22:53,573
and the whole world
just snapped into place.
525
00:22:53,673 --> 00:22:54,707
Mm.
526
00:22:54,807 --> 00:22:56,175
Nothing like it.
527
00:22:56,275 --> 00:22:58,644
You know, I actually
heard the man say "eureka."
528
00:22:58,645 --> 00:23:01,047
You know, he was the only person
in the world
529
00:23:01,180 --> 00:23:03,916
who could say that word
and not sound like an idiot.
530
00:23:04,016 --> 00:23:06,185
I don't know about that, guv.
531
00:23:07,019 --> 00:23:08,621
Might be one other.
532
00:23:10,923 --> 00:23:13,092
♪ ♪
533
00:23:14,927 --> 00:23:17,797
I haven't heard
from Damon in a long time.
534
00:23:20,366 --> 00:23:22,702
I was hoping
not to hear from him.
535
00:23:22,802 --> 00:23:25,705
Damon's been lying
to us for so long.
536
00:23:26,739 --> 00:23:28,941
Would you excuse me?
I'd love to talk to Autumn.
537
00:23:29,075 --> 00:23:31,143
Sure.
538
00:23:35,181 --> 00:23:37,717
Congratulations.
539
00:23:37,817 --> 00:23:39,486
Not easy
to get clean from heroin.
540
00:23:39,619 --> 00:23:41,219
Saw that recovery tattoo.
541
00:23:41,220 --> 00:23:42,889
It's good placement.
It covers up
542
00:23:42,989 --> 00:23:44,724
the scars from your track marks.
543
00:23:44,824 --> 00:23:46,758
So?
544
00:23:46,759 --> 00:23:49,361
I worked hard for my time.
No one's gonna shame me.
545
00:23:50,697 --> 00:23:52,231
Oh, that's not something I'd do.
546
00:23:52,331 --> 00:23:54,432
I'm here because you and your
cousin Damon had a common vice.
547
00:23:54,433 --> 00:23:56,102
And I didn't want
to embarrass you
548
00:23:56,202 --> 00:23:59,338
in front of your aunt, but
if you have ever used with him,
549
00:23:59,438 --> 00:24:01,908
if you know anything at all
that would help me find him,
550
00:24:02,008 --> 00:24:04,310
I'd appreciate it.
551
00:24:05,111 --> 00:24:06,813
So would Erika.
552
00:24:08,080 --> 00:24:10,349
If you change your mind.
553
00:24:13,553 --> 00:24:15,988
Christopher Maude.
Damon had a fake I.D.
554
00:24:16,088 --> 00:24:18,957
with the name
"Christopher Maude" on it.
555
00:24:18,958 --> 00:24:20,660
Whenever he was up
to something sketch,
556
00:24:20,793 --> 00:24:22,629
that's the alias he'd use.
557
00:24:24,130 --> 00:24:25,498
SASHA:
All right, thanks so much.
558
00:24:25,598 --> 00:24:26,899
Please call
if you hear anything.
559
00:24:28,167 --> 00:24:29,467
That's all the rehabs.
560
00:24:29,468 --> 00:24:31,337
Any luck with the hospitals?
561
00:24:31,437 --> 00:24:34,440
Is anyone else wondering
why we went to medical school?
562
00:24:34,541 --> 00:24:36,676
We work for a man
who'd rather text Scotland Yard
563
00:24:36,776 --> 00:24:38,044
than tell us about a case.
564
00:24:38,177 --> 00:24:39,946
His closest confidant is a man
565
00:24:40,046 --> 00:24:41,380
named Shinwell Johnson,
who, by the way,
566
00:24:41,480 --> 00:24:42,949
has definitely
killed people before.
567
00:24:43,049 --> 00:24:44,783
You chose this fellowship
568
00:24:44,784 --> 00:24:47,453
because it's too good
to pass up. We all did.
569
00:24:47,554 --> 00:24:48,787
But why did he pick us?
570
00:24:48,788 --> 00:24:50,189
ADAM: You seriously don't know?
571
00:24:50,289 --> 00:24:52,391
Watson sees the whole world
as an experiment
572
00:24:52,525 --> 00:24:53,826
in genetic medicine.
573
00:24:53,926 --> 00:24:56,062
We're just a part of it.
574
00:24:56,195 --> 00:24:59,732
Stephens and I have
identical DNA, same background.
575
00:24:59,866 --> 00:25:02,201
We even dated the same partner.
576
00:25:02,301 --> 00:25:05,404
We are a living test
of nature versus nurture.
577
00:25:06,205 --> 00:25:08,975
Sasha's a variation
on the same theme.
578
00:25:09,075 --> 00:25:10,710
You were born in China,
579
00:25:10,810 --> 00:25:13,880
presumably in a poor and
rural area, given prevailing
580
00:25:14,013 --> 00:25:15,247
adoption practices.
581
00:25:15,347 --> 00:25:16,815
You were adopted
into the wealthiest suburb
582
00:25:16,816 --> 00:25:18,517
in Dallas, Texas.
583
00:25:18,618 --> 00:25:21,220
Watson wants to see
how that turns out.
584
00:25:21,320 --> 00:25:23,222
I worked my ass off
in medical school.
585
00:25:23,322 --> 00:25:25,391
Hmm. I hope you don't think
that impressed Watson.
586
00:25:25,524 --> 00:25:27,492
We're not Sherlock Holmes,
587
00:25:27,493 --> 00:25:28,895
whoever that was.
588
00:25:29,028 --> 00:25:30,963
What about me?
589
00:25:34,266 --> 00:25:36,868
Honestly, I don't know.
590
00:25:36,869 --> 00:25:38,905
You, Ingrid...
591
00:25:39,005 --> 00:25:41,140
you're a mystery.
592
00:25:42,374 --> 00:25:44,510
SHINWELL: Welcome home, guv.
WATSON: Shinwell.
593
00:25:44,611 --> 00:25:47,113
Evening, everyone.
This is Damon Filipello.
594
00:25:47,246 --> 00:25:49,248
Let's, uh, book that O.R.
and get ready
595
00:25:49,381 --> 00:25:50,917
for the bone marrow harvest.
596
00:25:51,017 --> 00:25:53,152
Right this way.
597
00:25:53,252 --> 00:25:55,588
It's gonna be
a harmless procedure.
598
00:25:55,688 --> 00:25:57,123
INGRID: How did you find him?
599
00:25:57,256 --> 00:25:58,625
Inspector Gregson worked
a joint task force
600
00:25:58,758 --> 00:26:00,026
with the local police.
601
00:26:00,126 --> 00:26:02,261
An officer there
had a confidential informant
602
00:26:02,361 --> 00:26:04,096
who occasionally referred
to another hustler
603
00:26:04,196 --> 00:26:06,365
as "Christopher Maude."
604
00:26:06,465 --> 00:26:09,034
A stakeout ensued,
and here we are.
605
00:26:09,035 --> 00:26:10,970
Damon, you can just wait
right in here.
606
00:26:11,103 --> 00:26:13,105
Dr. Derian will get you
whatever you need.
607
00:26:13,239 --> 00:26:14,774
(phone buzzing)
608
00:26:14,874 --> 00:26:16,075
"A stakeout ensued"?
609
00:26:16,175 --> 00:26:17,610
That's a serious outlier
of a sentence.
610
00:26:17,744 --> 00:26:20,680
Yes, yes, outliers. Outliers...
611
00:26:20,780 --> 00:26:23,282
are where life happens,
Dr. Derian.
612
00:26:23,415 --> 00:26:25,517
(phone buzzing)
613
00:26:25,618 --> 00:26:26,918
Hello?
614
00:26:26,919 --> 00:26:28,788
AUTUMN:
Dr. Watson, it's Autumn Franco,
615
00:26:28,921 --> 00:26:30,022
Erika's cousin.
616
00:26:30,122 --> 00:26:31,757
Autumn, is everything okay?
617
00:26:31,758 --> 00:26:33,626
What's wrong?
618
00:26:33,760 --> 00:26:35,427
I'm sick.
619
00:26:35,527 --> 00:26:37,263
I'm sick, like Erika.
620
00:26:37,363 --> 00:26:39,298
What is happening to me?
621
00:26:46,238 --> 00:26:48,775
We're sick with the same thing?
622
00:26:48,908 --> 00:26:50,508
Did I catch it from Erika?
623
00:26:50,509 --> 00:26:52,678
I can't tell you that yet,
but we have to act like you did.
624
00:26:52,679 --> 00:26:54,747
(phone chiming, buzzing)
We've been through your houses,
625
00:26:54,847 --> 00:26:56,382
and now I have a team
going through everything
626
00:26:56,482 --> 00:26:58,117
you've both thrown away.
627
00:27:00,519 --> 00:27:01,552
(camera clicks)
628
00:27:01,553 --> 00:27:03,054
(phone whooshing, buzzing)
629
00:27:03,055 --> 00:27:04,690
Of course, you're cousins,
so we have to consider
630
00:27:04,691 --> 00:27:06,092
genetic causes, too.
631
00:27:06,192 --> 00:27:07,694
(phone chimes, buzzes)
632
00:27:08,494 --> 00:27:10,061
WATSON:
I want to focus on the times
633
00:27:10,062 --> 00:27:11,597
you were together
over the past month.
634
00:27:11,698 --> 00:27:13,099
You mentioned a pregnancy party.
635
00:27:13,199 --> 00:27:14,633
Is there anything else?
636
00:27:14,734 --> 00:27:16,936
No, no. Just the party.
637
00:27:18,671 --> 00:27:20,907
(phone chimes, buzzes)
638
00:27:26,245 --> 00:27:28,447
(phone chimes, buzzes)
639
00:27:30,416 --> 00:27:32,451
You're thinking
biotinidase deficiency, correct?
640
00:27:32,584 --> 00:27:34,286
ADAM: Neither of them
can recycle biotin.
641
00:27:34,386 --> 00:27:35,621
The avidin
from the raw eggs binds
642
00:27:35,722 --> 00:27:37,056
with what little biotin
they have.
643
00:27:37,156 --> 00:27:38,725
If I'm right,
they take a supplement,
644
00:27:38,825 --> 00:27:40,091
and they both get better.
645
00:27:40,092 --> 00:27:41,728
That is a good idea,
but it's also incorrect.
646
00:27:41,828 --> 00:27:44,562
Biotinidase deficiency
can only be inherited
647
00:27:44,563 --> 00:27:46,165
if both parents are carriers.
648
00:27:46,298 --> 00:27:48,300
Erika and Autumn
are maternal cousins.
649
00:27:48,400 --> 00:27:50,336
They're not sisters.
They can't...
650
00:27:50,436 --> 00:27:51,871
Can't both have it.
651
00:28:02,114 --> 00:28:04,383
(phone buzzing)
652
00:28:09,621 --> 00:28:11,390
Two dead birds.
653
00:28:13,559 --> 00:28:15,728
Are you all right, Dr. Watson?
654
00:28:18,164 --> 00:28:19,832
Erika, do you have a pet cat?
655
00:28:19,932 --> 00:28:21,868
Erika and Autumn have a form
656
00:28:22,001 --> 00:28:23,634
of salmonella poisoning.
657
00:28:23,635 --> 00:28:26,338
Typically shows up in cats
who hunt birds carrying
658
00:28:26,472 --> 00:28:28,841
the salmonella typhimurium
bacteria.
659
00:28:29,608 --> 00:28:31,477
SASHA: Watson?
660
00:28:32,344 --> 00:28:33,979
Stephen... s.
661
00:28:33,980 --> 00:28:36,883
Stephens. Give us a
lesson in infectious diseases.
662
00:28:37,016 --> 00:28:38,950
STEPHENS: Songbird fever
does show up in humans.
663
00:28:38,951 --> 00:28:42,054
Usually people who handle birds
killed by their pet cats.
664
00:28:42,188 --> 00:28:44,323
It tracks. It's Erika's cat.
She got sick first.
665
00:28:44,423 --> 00:28:46,959
Then Autumn started helping
at Erika's place. All right.
666
00:28:47,059 --> 00:28:49,028
Test them both for the bacteria.
If it comes up positive,
667
00:28:49,161 --> 00:28:51,563
put 'em on antibiotics
right away.
668
00:28:58,971 --> 00:29:01,007
INGRID: They last about
30 minutes, don't they?
669
00:29:01,107 --> 00:29:02,474
The incidents.
670
00:29:02,574 --> 00:29:03,876
It's called paroxysmal
sympathetic hyperactivity.
671
00:29:04,010 --> 00:29:06,813
It's a side effect
of traumatic brain injuries.
672
00:29:06,913 --> 00:29:09,415
This gets worse with time,
not better,
673
00:29:09,548 --> 00:29:12,051
which is probably why
you didn't tell me about it.
674
00:29:12,151 --> 00:29:13,484
Is there anything else?
675
00:29:13,485 --> 00:29:15,154
Yes. You're fired.
676
00:29:15,254 --> 00:29:18,657
I can't treat a patient who
hides their symptoms from me.
677
00:29:23,062 --> 00:29:25,297
Why do I work here?
678
00:29:26,999 --> 00:29:30,269
Adam and Stephens are twins.
Sasha's adopted.
679
00:29:30,402 --> 00:29:33,605
If this is an experiment,
how do I fit into it?
680
00:29:33,705 --> 00:29:35,074
There's no experiment.
681
00:29:35,174 --> 00:29:38,077
You're a very capable physician.
682
00:29:39,846 --> 00:29:41,080
Everything all right, guv?
683
00:29:41,213 --> 00:29:42,581
WATSON: Right as rain, Shinwell.
684
00:29:42,714 --> 00:29:44,250
Right as rain.
685
00:29:49,388 --> 00:29:51,991
You get those scrips
I wrote for you?
686
00:29:54,026 --> 00:29:56,527
Made my share of bargains,
687
00:29:56,528 --> 00:29:59,265
legal and otherwise.
688
00:29:59,398 --> 00:30:01,233
This one here...
689
00:30:02,068 --> 00:30:04,871
I don't know where it falls.
690
00:30:08,074 --> 00:30:11,409
These aren't controlled
substances, Shinwell.
691
00:30:11,410 --> 00:30:14,013
Medications have off-label uses.
692
00:30:14,813 --> 00:30:16,247
SHINWELL:
Well, that just sounds like
693
00:30:16,248 --> 00:30:17,748
you're experimenting
on yourself.
694
00:30:17,749 --> 00:30:19,952
I help myself get better
so I can help other people
695
00:30:20,052 --> 00:30:21,719
get better.
It's a straight line.
696
00:30:21,720 --> 00:30:24,090
If you're uncomfortable
with that, just let me know.
697
00:30:25,457 --> 00:30:27,860
(thunder rumbling)
698
00:30:30,729 --> 00:30:32,965
MARY: You slept here?
699
00:30:34,000 --> 00:30:35,834
Probably just as well.
700
00:30:35,935 --> 00:30:38,437
The storm has
half the bridges closed.
701
00:30:41,173 --> 00:30:43,009
John, the test results
came back.
702
00:30:43,109 --> 00:30:45,211
Autumn Franco
has songbird fever.
703
00:30:47,379 --> 00:30:49,581
Well, um...
704
00:30:51,583 --> 00:30:53,552
just get them
some antibiotics.
705
00:30:53,652 --> 00:30:55,521
Autumn Franco has it.
706
00:30:55,654 --> 00:30:57,189
Erika doesn't.
707
00:30:58,024 --> 00:30:59,391
Doesn't make any sense.
I'm sorry.
708
00:30:59,491 --> 00:31:01,160
There's an underlying condition.
709
00:31:03,829 --> 00:31:05,664
We also have
a more pressing issue.
710
00:31:05,797 --> 00:31:07,199
They're dying. What could be
more pressing than that?
711
00:31:07,333 --> 00:31:09,467
We already started Autumn
on antibiotics.
712
00:31:09,468 --> 00:31:12,270
This strain of songbird fever...
it's resistant.
713
00:31:12,271 --> 00:31:14,506
Autumn developed septicemia.
It's a matter of hours
714
00:31:14,640 --> 00:31:16,909
before she goes
into septic shock.
715
00:31:25,384 --> 00:31:27,353
Where are you going? Where
Holmes went when he got stuck.
716
00:31:27,453 --> 00:31:29,855
To the scene of the crime.
717
00:31:36,628 --> 00:31:38,597
So you're just gonna...
718
00:31:38,697 --> 00:31:41,100
(sniffles) ...look at us?
719
00:31:41,867 --> 00:31:43,802
ERIKA: You're out of ideas,
720
00:31:43,902 --> 00:31:45,371
aren't you?
721
00:31:45,471 --> 00:31:48,006
I want to deliver my baby.
722
00:31:48,007 --> 00:31:49,075
Today.
723
00:31:49,175 --> 00:31:51,077
Please. Before I get too weak.
724
00:31:51,177 --> 00:31:52,979
It's not over yet.
725
00:31:53,079 --> 00:31:54,446
There's something
that I'm missing.
726
00:31:54,546 --> 00:31:56,482
(sniffles)
We told you everything.
727
00:31:56,582 --> 00:31:58,217
You told me everything you know.
728
00:31:58,317 --> 00:31:59,518
Your faces, your bodies...
729
00:31:59,618 --> 00:32:04,423
everyone's faces and bodies
are clues.
730
00:32:04,556 --> 00:32:08,159
Tell us who we are,
where we came from
731
00:32:08,160 --> 00:32:10,729
and what's gonna happen to us.
732
00:32:11,563 --> 00:32:12,764
You two don't look
733
00:32:12,864 --> 00:32:13,932
especially similar,
but one look,
734
00:32:14,066 --> 00:32:15,334
and I bet you're related.
735
00:32:15,434 --> 00:32:16,969
You both have
orbital hypertelorism...
736
00:32:17,069 --> 00:32:18,670
your eyes are widely spaced.
737
00:32:18,770 --> 00:32:20,372
And that could be a coincidence,
but then I see you both have
738
00:32:20,472 --> 00:32:21,740
two-three syndactyly,
739
00:32:21,873 --> 00:32:23,442
and suddenly,
we got two traits in common.
740
00:32:23,575 --> 00:32:25,944
Two-three what?
Syndactyly. Webbed toes.
741
00:32:26,045 --> 00:32:28,546
The skin on your second
and third toes never separated.
742
00:32:28,547 --> 00:32:30,249
I assume both
of your mothers had it,
743
00:32:30,349 --> 00:32:31,850
since that's how you're related.
744
00:32:31,950 --> 00:32:33,419
Actually, no.
745
00:32:33,519 --> 00:32:37,389
My mother doesn't have it.
My father did.
746
00:32:37,489 --> 00:32:39,258
My mom didn't, either.
747
00:32:39,391 --> 00:32:40,759
Neither of my parents did.
748
00:32:40,892 --> 00:32:42,261
That's impossible.
749
00:32:42,361 --> 00:32:43,562
You can't have syndactyly
750
00:32:43,662 --> 00:32:44,663
if neither one
of your parents had it.
751
00:32:44,763 --> 00:32:45,931
But I do.
752
00:32:46,065 --> 00:32:48,100
And they didn't.
753
00:32:50,202 --> 00:32:51,603
WATSON: Neither one of
Autumn Franco's parents
754
00:32:51,703 --> 00:32:53,305
could have possibly
passed the mutation
755
00:32:53,405 --> 00:32:56,041
to two-three syndactyly,
but yet she has it anyway. How?
756
00:32:56,042 --> 00:32:58,310
The only explanation
is that she's wrong
757
00:32:58,444 --> 00:32:59,544
about who her parents are.
758
00:32:59,545 --> 00:33:00,912
WATSON: Exactly.
759
00:33:01,013 --> 00:33:02,748
Erika Filipello's father
had two-three syndactyly.
760
00:33:02,848 --> 00:33:04,783
He passed it down to Erika
and her brother Damon,
761
00:33:04,883 --> 00:33:06,452
and there's no mystery there.
762
00:33:06,552 --> 00:33:08,820
Does anyone notice
anything unusual
763
00:33:08,920 --> 00:33:11,490
about Paul Filipello's eyes?
764
00:33:11,623 --> 00:33:12,858
They're widely spaced.
765
00:33:12,958 --> 00:33:16,928
He has a slight case
of orbital hypertelorism.
766
00:33:17,029 --> 00:33:19,298
WATSON: Notice anyone
else with hypertelorism?
767
00:33:19,431 --> 00:33:20,766
INGRID: Erika.
768
00:33:20,866 --> 00:33:22,634
Her brother, of course.
769
00:33:23,835 --> 00:33:25,704
Oh, my God.
770
00:33:25,804 --> 00:33:27,173
Autumn has it, too.
771
00:33:27,273 --> 00:33:29,441
Two-three syndactyly
and orbital hypertelorism,
772
00:33:29,541 --> 00:33:33,179
two traits that flowed down
from Erika to her brother Damon
773
00:33:33,279 --> 00:33:35,347
to Autumn, all from one source.
774
00:33:35,447 --> 00:33:38,484
Wait, you're saying Erika's
father is Autumn's father, too?
775
00:33:38,617 --> 00:33:41,153
Erika and Autumn
aren't just cousins.
776
00:33:42,921 --> 00:33:44,556
They're half sisters, too.
777
00:33:47,326 --> 00:33:49,295
Eureka.
778
00:33:54,666 --> 00:33:56,767
Autumn's my sister?
779
00:33:56,768 --> 00:33:58,637
Half sister.
Three-quarter siblings.
780
00:33:58,737 --> 00:34:00,672
This is incredible news.
If I'm right,
781
00:34:00,772 --> 00:34:02,974
you two share a mutation
to the BTD gene.
782
00:34:03,075 --> 00:34:04,376
It gives the body instructions
783
00:34:04,476 --> 00:34:06,178
for making the enzyme
biotinidase.
784
00:34:06,278 --> 00:34:09,381
Unchecked biotinidase explains
all of your symptoms.
785
00:34:09,481 --> 00:34:11,183
(laughs softly) Now,
we still have to treat.
786
00:34:11,283 --> 00:34:12,651
Autumn's songbird fever.
787
00:34:12,751 --> 00:34:14,486
Other than that,
788
00:34:14,586 --> 00:34:17,788
all you need is
a ten-dollar biotin supplement,
789
00:34:17,789 --> 00:34:19,624
available at any drugstore.
790
00:34:19,625 --> 00:34:21,727
You'll be able to see again.
791
00:34:21,827 --> 00:34:23,362
You'll carry your baby to term.
792
00:34:23,495 --> 00:34:26,965
I-I'm gonna live?
M-My baby's gonna live?
793
00:34:27,065 --> 00:34:28,966
Yes.
794
00:34:28,967 --> 00:34:32,371
(grunting softly) Autumn?
795
00:34:32,471 --> 00:34:34,072
Autumn.
796
00:34:36,175 --> 00:34:37,376
(rapid beeping)
797
00:34:37,476 --> 00:34:38,710
Patient is in septic shock.
798
00:34:38,844 --> 00:34:40,678
We need the ultrasound
to find the abscess
799
00:34:40,679 --> 00:34:42,013
and surgery to cut it out.
NURSE: Understood, Dr. Watson.
800
00:34:42,114 --> 00:34:43,715
Where's the surgeon?
801
00:34:45,684 --> 00:34:46,752
Where's the surgeon?
802
00:34:46,885 --> 00:34:48,154
The bridges are closed.
803
00:34:48,254 --> 00:34:49,755
The resident should
be here soon. Soon?
804
00:34:49,855 --> 00:34:51,890
Soon she'll be dead.
805
00:34:53,659 --> 00:34:55,794
(thunder crashes)
806
00:35:08,940 --> 00:35:10,442
MARY: Good afternoon, everyone.
807
00:35:10,542 --> 00:35:11,977
This patient has
what looked like
808
00:35:12,077 --> 00:35:14,580
multiple abscesses
on the ultrasound.
809
00:35:14,680 --> 00:35:17,115
They're around the liver,
and we need to move quickly.
810
00:35:17,249 --> 00:35:19,585
CASSIE: Dr. Morstan? ("Rainbow"
by Kacey Musgraves playing)
811
00:35:19,685 --> 00:35:21,018
We got your favorite.
812
00:35:21,019 --> 00:35:22,353
Good memory, Cassie.
813
00:35:22,354 --> 00:35:24,256
I haven't operated
in four years.
814
00:35:24,356 --> 00:35:27,393
♪ ♪
815
00:35:32,931 --> 00:35:36,535
♪ When it rains, it pours ♪
816
00:35:36,635 --> 00:35:39,904
♪ But you didn't even notice ♪
817
00:35:39,905 --> 00:35:43,475
♪ It ain't raining anymore... ♪
818
00:35:43,575 --> 00:35:45,677
MARY: There she is.
819
00:35:45,777 --> 00:35:48,113
Look how beautiful.
820
00:35:49,781 --> 00:35:52,618
Did we tell you we
picked out a name?
821
00:35:52,718 --> 00:35:55,221
Autumn. After her aunt.
822
00:35:55,321 --> 00:35:58,557
I have to get used to
thinking of myself that way.
823
00:36:00,526 --> 00:36:04,094
Get used to thinking of yourself
as a godmother, too.
824
00:36:04,095 --> 00:36:07,699
Seriously? You want to make
this relationship more tangled?
825
00:36:07,799 --> 00:36:09,535
(laughs)
826
00:36:11,203 --> 00:36:13,205
♪ You hold tight
to your umbrella... ♪
827
00:36:13,305 --> 00:36:15,441
Just give it a sec.
828
00:36:15,541 --> 00:36:16,775
She'll move.
829
00:36:16,875 --> 00:36:18,576
♪ Trying to tell you ♪
830
00:36:18,577 --> 00:36:21,780
♪ That there's always been
a rainbow... ♪
831
00:36:21,880 --> 00:36:24,383
WATSON:
Got an update on Autumn Franco.
832
00:36:24,483 --> 00:36:26,151
The treatment
has run its course.
833
00:36:26,252 --> 00:36:28,086
Her songbird fever's gone.
834
00:36:28,186 --> 00:36:30,021
We're gonna be
discharging her tomorrow.
835
00:36:30,155 --> 00:36:32,258
So, thank you for everything.
836
00:36:33,158 --> 00:36:34,793
Night, Dr. Watson.
837
00:36:37,162 --> 00:36:39,264
Ingrid.
838
00:36:39,265 --> 00:36:41,533
I hired you
because of your résumé.
839
00:36:41,633 --> 00:36:43,669
No, that's the truth.
840
00:36:43,769 --> 00:36:46,004
It was one of the best
CVs I've ever seen.
841
00:36:46,104 --> 00:36:48,006
And down at the bottom,
in the... in the fine print,
842
00:36:48,106 --> 00:36:50,842
said that you played
Lady Macbeth in college.
843
00:36:50,942 --> 00:36:52,911
There was no production
of Lady Macbeth
844
00:36:53,011 --> 00:36:54,945
while you were at the
University of Chicago.
845
00:36:54,946 --> 00:36:57,349
You lied.
846
00:36:57,449 --> 00:36:59,418
You have all of
the qualifications in the world,
847
00:36:59,518 --> 00:37:02,287
yet you... you lied anyway.
848
00:37:02,288 --> 00:37:05,023
(laughs softly)
849
00:37:05,123 --> 00:37:08,793
So, you hired me
because you think I'm a liar?
850
00:37:08,794 --> 00:37:11,697
I hired you because there's
conflict inside of you.
851
00:37:12,531 --> 00:37:14,533
It sounds like
you're diagnosing me.
852
00:37:14,633 --> 00:37:16,967
Your every impulse,
it pushes you to...
853
00:37:16,968 --> 00:37:18,304
put yourself first,
854
00:37:18,404 --> 00:37:19,838
but you try to be
a decent person anyway.
855
00:37:19,938 --> 00:37:24,610
Maybe I want to see which
side wins in the end.
856
00:37:25,611 --> 00:37:30,316
Or maybe Moriarty gave me
a clinical interest in...
857
00:37:30,416 --> 00:37:32,117
people like you.
858
00:37:35,921 --> 00:37:37,456
We'll set an appointment?
859
00:37:37,556 --> 00:37:40,258
You get one more shot.
860
00:37:40,359 --> 00:37:42,628
Stop making me fight my way in.
861
00:37:44,363 --> 00:37:47,899
♪ Yeah, there's always
been a rainbow ♪
862
00:37:48,033 --> 00:37:51,803
♪ Hanging over ♪
863
00:37:51,903 --> 00:37:54,606
♪ Your head ♪
864
00:37:54,706 --> 00:37:57,008
♪ Mm ♪
865
00:37:58,877 --> 00:38:03,749
♪ It'll all be all right. ♪
866
00:38:08,420 --> 00:38:10,422
(song ends)
867
00:38:15,661 --> 00:38:17,829
Sorry it took so long.
868
00:38:18,630 --> 00:38:20,832
What's in there, anyway?
869
00:38:22,634 --> 00:38:25,136
You could have told me.
870
00:38:25,270 --> 00:38:26,938
I'm not made of glass.
871
00:38:27,038 --> 00:38:29,074
Somebody's been staying here.
872
00:38:29,875 --> 00:38:32,042
You own one car,
the second parking space
873
00:38:32,043 --> 00:38:33,278
is free of clutter.
874
00:38:33,412 --> 00:38:36,147
Coat hook on the inside
is completely clear.
875
00:38:36,281 --> 00:38:39,250
A coat hook is never just empty.
876
00:38:39,351 --> 00:38:42,052
Unless somebody
cleaned it off in a hurry.
877
00:38:42,053 --> 00:38:44,122
Is it anyone I know?
878
00:38:45,391 --> 00:38:47,493
You never met her.
879
00:38:48,360 --> 00:38:50,928
You are a better
doctor now, John.
880
00:38:50,929 --> 00:38:53,832
Whatever you did over
there with Holmes,
881
00:38:53,932 --> 00:38:55,400
it made you better.
882
00:38:55,401 --> 00:38:58,537
I mean, you were always good.
883
00:38:58,637 --> 00:39:01,206
But you learned things
with him. It's like...
884
00:39:01,306 --> 00:39:05,844
you can see into people's bodies
and their souls.
885
00:39:05,944 --> 00:39:08,814
I'm lucky to be around you.
886
00:39:08,914 --> 00:39:12,784
But the old us...
887
00:39:14,986 --> 00:39:17,022
is never coming back.
888
00:39:19,290 --> 00:39:21,793
And what is the new us?
889
00:39:33,672 --> 00:39:37,208
You think I'm the reason
you survived that fall,
890
00:39:37,308 --> 00:39:39,545
but there's something else.
891
00:39:39,645 --> 00:39:41,513
You have to find it.
892
00:39:41,613 --> 00:39:43,815
♪ ♪
893
00:40:10,408 --> 00:40:12,210
The game's afoot.
894
00:40:12,310 --> 00:40:13,411
We have a new case.
895
00:40:13,545 --> 00:40:16,715
Who wants to amaze us
with their insights?
896
00:40:18,149 --> 00:40:20,285
♪ ♪
897
00:40:23,889 --> 00:40:25,624
(bell rings)
898
00:40:32,330 --> 00:40:34,399
I could sit here all day.
899
00:40:35,901 --> 00:40:37,268
This view.
900
00:40:37,402 --> 00:40:40,739
The city looks so vulnerable.
901
00:40:44,375 --> 00:40:47,879
A fire might sweep
down from the north.
902
00:40:47,979 --> 00:40:50,949
Those rivers could rise.
903
00:40:51,082 --> 00:40:52,417
Who knows?
904
00:40:52,551 --> 00:40:56,955
A germ may even write its
name into history here.
905
00:40:57,756 --> 00:40:59,023
How would you grant this place
906
00:40:59,024 --> 00:41:01,593
the mercy of nonexistence,
Shinwell?
907
00:41:01,693 --> 00:41:04,796
You know, I'm not really one
for big ideas.
908
00:41:04,896 --> 00:41:07,332
Professor Moriarty, I presume.
909
00:41:07,432 --> 00:41:09,601
I was expecting someone...
910
00:41:09,701 --> 00:41:11,737
different.
911
00:41:22,781 --> 00:41:23,715
Here you go.
912
00:41:23,815 --> 00:41:26,217
The samples you wanted.
913
00:41:51,142 --> 00:41:53,378
I'm watching.
914
00:41:54,746 --> 00:41:57,816
Always and everywhere.
915
00:42:02,654 --> 00:42:04,823
(shuddering)
916
00:42:08,526 --> 00:42:10,662
♪ ♪
917
00:42:12,397 --> 00:42:15,166
Captioning sponsored by CBS.
918
00:42:15,266 --> 00:42:18,704
Captioned by Media Access
Group at WGBH access.wgbh.org