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MICHAEL HEMANN: OK.
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So how do we figure out what the double recombination
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events are?
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Well, essentially, we just try out
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what things would look like if they
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were in all of the different possible orders.
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So there are three orders that could possibly
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exist amongst these genes.
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We're going to model these double crossovers.
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And we're going to see which one appears
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to be the double crossover based on the numbers that we see,
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right?
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So let's look at order number one, right?
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Say we have wingless minus M1A M2A.
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Now, that's the way I've drawn it before.
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But now we're saying that this is actually
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the order that they're in on the chromosome.
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So we have that.
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And we have, then, wingless plus M1B M2B.
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So we're going to have--
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what would happen if there's a double crossover there, right?
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So that recombination product that you would get
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would be wingless minus M1B M2A and wingless plus M1A M2B.
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How is this working?
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Well, I'm starting over here at wingless.
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I'm going down to M1B, and I'm going back up to M2A.
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So you're getting wingless minus M1B M2A.
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The gametes are wingless minus M1B M2A and wingless plus M1A
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M2B.
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OK.
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So that's one possible order.
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The second possible order would be M1A wingless minus M2A
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and M1B wingless plus M2B, right?
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Again, we think about what would happen if there's
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a double crossover here.
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And the result would be M1A wingless plus M2A.
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And you would get M1B wingless minus M2B.
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And the gametes-- we can write out--
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in this case, I'm not writing out the order.
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I'm just writing out based on the same sort of convention
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of what the gametes would look like from a genetic standpoint.
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So this gamete would be wingless plus M1A M2A
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and wingless minus M1B M2B.
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Let's think about a third order here.
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And the third order would be the final order,
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which would be M1A M2A wingless minus and M1B M2B wingless
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plus.
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I doublecross over here, right?
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And the results would be M1A M2B wingless minus and M1B M2A
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wingless plus, right?
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And we write those all with the same sort of convention here.
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We have wingless minus M1A M2B.
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And we have wingless plus M1B M2A.
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4324
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