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These are the user uploaded subtitles that are being translated: 1 00:00:01,377 --> 00:00:04,294 From the plagues of egypt 2 00:00:04,380 --> 00:00:06,296 to the black death, 3 00:00:06,382 --> 00:00:08,382 smallpox, 4 00:00:08,467 --> 00:00:10,134 cholera, 5 00:00:10,219 --> 00:00:12,011 and the spanish flu, 6 00:00:12,054 --> 00:00:15,889 humans have repeatedly faced contagious diseases 7 00:00:15,975 --> 00:00:20,185 that have the power to change the course of history. 8 00:00:20,896 --> 00:00:24,064 We like to think that modern medicine 9 00:00:24,150 --> 00:00:27,860 can protect us against almost everything, but... 10 00:00:27,903 --> 00:00:29,653 Is that really true? 11 00:00:29,697 --> 00:00:31,780 Or are we destined to face a future 12 00:00:31,866 --> 00:00:36,326 of ever more potent illnesses 13 00:00:36,412 --> 00:00:40,247 that attack without warning 14 00:00:40,332 --> 00:00:43,667 and can bring civilization to its knees? 15 00:00:43,753 --> 00:00:45,586 Well... 16 00:00:46,839 --> 00:00:49,298 ...That is what we'll try and find out. 17 00:00:51,000 --> 00:00:57,074 Advertise your product or brand here contact www.OpenSubtitles.org today 18 00:01:06,567 --> 00:01:08,567 News reports surface that a new, 19 00:01:08,611 --> 00:01:13,113 highly contagious disease first discovered in wuhan, china, 20 00:01:13,199 --> 00:01:16,116 is spreading like wildfire. 21 00:01:16,202 --> 00:01:18,535 In a matter of weeks, the lethal virus... 22 00:01:18,621 --> 00:01:22,039 Known as "coronavirus" or "covid-19"... 23 00:01:22,124 --> 00:01:23,707 Sweeps the globe. 24 00:01:23,793 --> 00:01:25,334 On March 11, 25 00:01:25,419 --> 00:01:27,219 as the number of infections and deaths 26 00:01:27,296 --> 00:01:29,379 continue to climb, 27 00:01:29,465 --> 00:01:32,216 the world health organization declares 28 00:01:32,259 --> 00:01:36,178 that the outbreak has become a worldwide pandemic. 29 00:01:37,264 --> 00:01:39,515 What separates, clinically, 30 00:01:39,600 --> 00:01:43,769 coronavirus from other common viruses such as influenza 31 00:01:43,813 --> 00:01:46,772 is that it knows how to hide itself. 32 00:01:47,691 --> 00:01:53,070 It has what we call a period where you could be asymptomatic. 33 00:01:53,155 --> 00:01:55,072 That means without symptoms. 34 00:01:55,157 --> 00:01:58,659 That's a chance to pass that virus to other people, 35 00:01:58,744 --> 00:02:01,954 keeping the disease going on and spreading. 36 00:02:02,039 --> 00:02:04,498 Most of the time, when you wait for these symptoms, 37 00:02:04,583 --> 00:02:06,208 you've already missed it. 38 00:02:07,128 --> 00:02:08,980 In the wake of the harrowing effects 39 00:02:09,004 --> 00:02:10,879 of the coronavirus outbreak, 40 00:02:10,965 --> 00:02:13,173 scientists have been compelled to reexamine 41 00:02:13,259 --> 00:02:17,219 the nature of viruses themselves. 42 00:02:19,348 --> 00:02:21,515 Viruses are very mysterious, 43 00:02:21,600 --> 00:02:23,392 because you can't see them. 44 00:02:23,477 --> 00:02:25,894 You need a very powerful microscope 45 00:02:25,980 --> 00:02:27,187 to be able to see them. 46 00:02:27,273 --> 00:02:30,232 And we didn't even know that they were around 47 00:02:30,317 --> 00:02:33,652 until relatively recently. 48 00:02:34,864 --> 00:02:37,884 A virus is essentially a bit of nucleic acid, 49 00:02:37,908 --> 00:02:39,533 either dna or rna, 50 00:02:39,618 --> 00:02:42,452 encapsulated in some sort of coating. Right? 51 00:02:42,538 --> 00:02:46,248 So it needs to... it needs to get into another organism 52 00:02:46,333 --> 00:02:50,460 and then essentially hijack that organism's cellular machinery 53 00:02:50,504 --> 00:02:53,338 to make more copies of itself. 54 00:02:54,633 --> 00:02:56,027 It needs to 55 00:02:56,051 --> 00:02:58,844 actually take over another living cell. 56 00:02:58,888 --> 00:03:01,305 And whether that's the living cell of a human, 57 00:03:01,390 --> 00:03:02,681 animal, 58 00:03:02,725 --> 00:03:05,893 plant or even a bacteria, 59 00:03:05,978 --> 00:03:07,477 it needs that. 60 00:03:07,563 --> 00:03:09,980 It's making more and more viruses 61 00:03:10,065 --> 00:03:11,940 till that cell is not needed anymore. 62 00:03:13,444 --> 00:03:16,153 A virus relies on either 63 00:03:16,238 --> 00:03:19,656 direct transmission through sneezing or coughing 64 00:03:19,742 --> 00:03:21,428 or touching, um, a viral particle 65 00:03:21,452 --> 00:03:22,951 from a person who's expelled it. 66 00:03:24,747 --> 00:03:28,290 Or they rely on a mosquito or some other organism 67 00:03:28,375 --> 00:03:30,295 to be transmitted between people. 68 00:03:31,253 --> 00:03:33,086 And so the density of people 69 00:03:33,172 --> 00:03:36,548 will facilitate quicker spread of viruses, 70 00:03:36,634 --> 00:03:38,884 especially if it's, um, relatively contagious 71 00:03:38,969 --> 00:03:42,095 and-and easy to-to transfer from one person to another. 72 00:03:42,932 --> 00:03:44,681 According to experts, 73 00:03:44,767 --> 00:03:46,516 the origins of many viruses 74 00:03:46,602 --> 00:03:49,561 remain shrouded in mystery. 75 00:03:49,605 --> 00:03:51,208 It's so difficult 76 00:03:51,232 --> 00:03:53,815 to determine the origin of viruses because, 77 00:03:53,901 --> 00:03:56,151 when you want to study that virus, 78 00:03:56,237 --> 00:04:01,031 you have to separate what is the natural history of that cell. 79 00:04:01,075 --> 00:04:02,908 So one of the important things 80 00:04:02,993 --> 00:04:06,995 that epidemiologists are looking at right now is, 81 00:04:07,081 --> 00:04:09,248 what did we learn from the past? 82 00:04:09,333 --> 00:04:10,874 What should we be looking at? 83 00:04:10,960 --> 00:04:12,584 Where should we be looking? 84 00:04:14,630 --> 00:04:18,382 Some of the earliest records of plagues 85 00:04:18,467 --> 00:04:21,343 are found in ancient india, 86 00:04:21,428 --> 00:04:23,929 china, the middle east, 87 00:04:24,014 --> 00:04:26,890 and they talk about plagues occurring 88 00:04:26,976 --> 00:04:29,309 before the very first civilization, 89 00:04:29,395 --> 00:04:32,104 around 3200 bc. 90 00:04:32,189 --> 00:04:34,231 Throughout human history, 91 00:04:34,275 --> 00:04:36,566 there have been accounts of devastating afflictions 92 00:04:36,610 --> 00:04:41,113 that defied understanding at the time they happened. 93 00:04:41,156 --> 00:04:44,741 But perhaps a closer examination of these plagues 94 00:04:44,827 --> 00:04:48,954 will provide some lessons about infectious diseases 95 00:04:48,998 --> 00:04:51,206 and how they begin. 96 00:04:59,675 --> 00:05:03,260 Emperor justinian sits atop a powerful throne. 97 00:05:03,345 --> 00:05:06,805 But lurking in the shadows is a hidden enemy 98 00:05:06,890 --> 00:05:09,933 about to consume his kingdom. 99 00:05:11,103 --> 00:05:12,561 A plague 100 00:05:12,646 --> 00:05:14,896 started by a bacteria 101 00:05:14,982 --> 00:05:16,648 comes out of the east 102 00:05:16,734 --> 00:05:19,109 and infects. 103 00:05:19,194 --> 00:05:21,695 This simple bacteria 104 00:05:21,780 --> 00:05:23,655 ended up killing 105 00:05:23,699 --> 00:05:29,244 almost one half the population of the entire old empire. 106 00:05:29,330 --> 00:05:32,539 With that type of death toll, 107 00:05:32,624 --> 00:05:36,501 the economic and social ramifications 108 00:05:36,587 --> 00:05:38,170 were catastrophic. 109 00:05:38,213 --> 00:05:42,299 Everything that justinian had tried 110 00:05:42,384 --> 00:05:43,592 was now collapsing. 111 00:05:43,677 --> 00:05:47,095 His military collapsed, his economy collapsed. 112 00:05:47,181 --> 00:05:50,140 And everything that he tried to do 113 00:05:50,184 --> 00:05:52,142 was of no avail. 114 00:05:53,562 --> 00:05:56,605 Justinian plague is caused by a bacterium, 115 00:05:56,690 --> 00:05:58,398 yersinia pestis. 116 00:05:58,484 --> 00:06:01,318 It can either enter humans directly, um, through... 117 00:06:01,403 --> 00:06:03,362 From saliva or-or coughing. 118 00:06:03,405 --> 00:06:05,072 It usually manifests itself 119 00:06:05,157 --> 00:06:06,968 in terms of swelling of the lymph nodes. 120 00:06:06,992 --> 00:06:09,493 The skin turns black and basically dies. 121 00:06:09,578 --> 00:06:11,014 And then there's a progression of fever 122 00:06:11,038 --> 00:06:12,954 and chills and eventual death. 123 00:06:13,957 --> 00:06:18,293 As justinian's empire was collapsing and breaking 124 00:06:18,379 --> 00:06:21,463 and his military strength was waning... 125 00:06:21,548 --> 00:06:24,257 Because the science of medicine in those days 126 00:06:24,343 --> 00:06:27,636 was far more primitive than we have today. 127 00:06:27,721 --> 00:06:30,472 People cry out, "why? 128 00:06:30,557 --> 00:06:32,349 Why is this happening?" 129 00:06:33,519 --> 00:06:36,395 The plague of justinian, as it became known, 130 00:06:36,438 --> 00:06:40,023 ultimately killed an estimated 50 million people. 131 00:06:40,067 --> 00:06:42,984 The vast byzantine empire was crippled 132 00:06:43,070 --> 00:06:45,362 not by an invading army 133 00:06:45,447 --> 00:06:50,909 but by an enemy they could not see and did not understand. 134 00:06:51,954 --> 00:06:53,453 At the time, 135 00:06:53,539 --> 00:06:56,206 since the existence of bacteria and viruses 136 00:06:56,291 --> 00:06:58,583 had not yet been discovered, 137 00:06:58,627 --> 00:07:03,171 many believed that the invisible force that caused the plague 138 00:07:03,257 --> 00:07:05,424 was god himself. 139 00:07:05,509 --> 00:07:07,509 It was a belief that was widely accepted, 140 00:07:07,594 --> 00:07:10,137 because people would read in the bible 141 00:07:10,222 --> 00:07:13,056 about how pestilence from the past 142 00:07:13,142 --> 00:07:16,351 had been created by the hand of god. 143 00:07:18,480 --> 00:07:22,774 Whenever humanity is infected 144 00:07:22,818 --> 00:07:27,654 by something greater and beyond human understanding, 145 00:07:27,739 --> 00:07:32,993 it has always been psychologically understood 146 00:07:33,078 --> 00:07:38,165 to be an expression of the wrath of god. 147 00:07:38,917 --> 00:07:41,084 We have in the book of exodus 148 00:07:41,128 --> 00:07:44,463 the famous ten plagues of egypt. 149 00:07:44,506 --> 00:07:49,718 Moses had come back after seeing god on the mountain 150 00:07:49,803 --> 00:07:52,596 to free the hebrews from slavery. 151 00:07:52,681 --> 00:07:57,100 He went before the pharaoh and asked to let his people go. 152 00:07:57,186 --> 00:07:59,561 Of course, the pharaoh said no. 153 00:07:59,646 --> 00:08:04,232 Therefore, the hebrew god sent a number of plagues through egypt. 154 00:08:07,654 --> 00:08:10,113 The bible stories are clear. 155 00:08:10,157 --> 00:08:14,826 The order of the plagues are well-documented in the bible. 156 00:08:14,912 --> 00:08:16,703 We know, of course, 157 00:08:16,788 --> 00:08:20,373 that there was the turning of the nile into blood. 158 00:08:20,459 --> 00:08:22,250 There were the frogs, the lice, 159 00:08:22,336 --> 00:08:24,794 the pestilence and, of course, 160 00:08:24,880 --> 00:08:27,797 the great plagues of the three days of darkness 161 00:08:27,883 --> 00:08:30,675 and, of course, the death of the firstborn. 162 00:08:32,679 --> 00:08:35,847 The biblical writer who is writing what happens 163 00:08:35,933 --> 00:08:37,307 and is inspired by god 164 00:08:37,351 --> 00:08:39,267 does say that the plague stopped 165 00:08:39,353 --> 00:08:42,020 after the hebrews were finally free. 166 00:08:42,064 --> 00:08:45,941 So, perhaps there was some divine intervention from god. 167 00:08:46,026 --> 00:08:47,651 But we'll never know, 168 00:08:47,736 --> 00:08:50,153 because miracles are very difficult to prove. 169 00:08:50,239 --> 00:08:52,697 Was there a higher power involved 170 00:08:52,783 --> 00:08:56,660 that both started and ended the plagues of egypt 171 00:08:56,745 --> 00:08:59,037 and the plague of justinian? 172 00:08:59,122 --> 00:09:03,333 Perhaps more clues as to what causes devastating plagues 173 00:09:03,418 --> 00:09:06,086 can be found by examining the disease responsible 174 00:09:06,171 --> 00:09:09,297 for claiming more lives than any other. 175 00:09:20,519 --> 00:09:24,062 Officials from the california odepartment of public health 176 00:09:24,106 --> 00:09:27,899 alert residents that a woman has tested positive 177 00:09:27,943 --> 00:09:32,070 for a dangerous and quite unexpected disease. 178 00:09:33,156 --> 00:09:35,198 The bubonic plague, 179 00:09:35,284 --> 00:09:38,952 otherwise known as the black death. 180 00:09:39,913 --> 00:09:42,455 Does the bubonic plague still exist? 181 00:09:42,541 --> 00:09:45,000 The answer is... Yes. 182 00:09:45,085 --> 00:09:46,501 And it's amazing 183 00:09:46,587 --> 00:09:49,296 how, many centuries later, 184 00:09:49,381 --> 00:09:52,048 you could say this with a calm voice. 185 00:09:52,134 --> 00:09:53,842 What is the difference? 186 00:09:53,927 --> 00:09:56,678 The answer is antibiotics. 187 00:09:56,763 --> 00:09:59,639 We know that if you have symptoms early 188 00:09:59,725 --> 00:10:03,268 that antibiotics can save your life. 189 00:10:03,353 --> 00:10:06,771 While it's not as prevalent anymore, 190 00:10:06,815 --> 00:10:10,775 the plague is certainly still in circulation. 191 00:10:10,861 --> 00:10:12,547 In the united states, right, in more rural areas, 192 00:10:12,571 --> 00:10:14,613 where people come into contact with-with rodents 193 00:10:14,656 --> 00:10:16,197 that might be infected with it, 194 00:10:16,283 --> 00:10:19,284 it's still known to, like, crop up here and there. 195 00:10:21,288 --> 00:10:24,247 The worst case of the bubonic plague that there was 196 00:10:24,291 --> 00:10:26,124 was known as the black death, 197 00:10:26,168 --> 00:10:29,878 in the middle of the 1300s. 198 00:10:29,963 --> 00:10:32,255 And that wiped out 199 00:10:32,299 --> 00:10:38,136 60% of all of europe's population. 200 00:10:42,476 --> 00:10:45,143 12 trade ships arrive 201 00:10:45,187 --> 00:10:46,978 from the black sea 202 00:10:47,022 --> 00:10:50,065 and drift into the port of messina to unload freight. 203 00:10:50,150 --> 00:10:51,983 As dockworkers 204 00:10:52,069 --> 00:10:53,443 approach the vessels, 205 00:10:53,487 --> 00:10:56,279 they discover a disturbing scene. 206 00:10:56,365 --> 00:10:59,282 The port master goes on board 207 00:10:59,368 --> 00:11:02,661 to see the crew, and, to their surprise, 208 00:11:02,704 --> 00:11:05,330 it was almost like there were zombies on the ship. 209 00:11:05,374 --> 00:11:08,500 Gangrene fingers. 210 00:11:08,543 --> 00:11:10,543 Big boils. 211 00:11:10,629 --> 00:11:11,836 And if I saw 212 00:11:11,922 --> 00:11:14,047 a crew that had black fingers 213 00:11:14,132 --> 00:11:15,757 and boils, let's be honest: 214 00:11:15,842 --> 00:11:18,343 It sounds like a zombie apocalypse. 215 00:11:18,428 --> 00:11:21,262 The black death seemed to have been introduced 216 00:11:21,348 --> 00:11:22,138 via the silk road, 217 00:11:22,224 --> 00:11:24,516 which is a major trading route 218 00:11:24,601 --> 00:11:27,519 in the early medieval period from central asia 219 00:11:27,604 --> 00:11:30,647 where the bubonic plague regularly pops up. 220 00:11:30,732 --> 00:11:32,899 Europe seems to have been largely unprepared 221 00:11:32,984 --> 00:11:34,484 for this devastating event. 222 00:11:34,528 --> 00:11:36,152 This is in the 1300s. 223 00:11:36,196 --> 00:11:37,696 It went for quite a few years, 224 00:11:37,739 --> 00:11:41,866 and whole villages and areas were wiped out. 225 00:11:41,910 --> 00:11:45,245 And like many plagues, uh, people wondered why. 226 00:11:45,330 --> 00:11:47,475 These cities would get the plague, 227 00:11:47,499 --> 00:11:49,040 and no one knew why. 228 00:11:49,084 --> 00:11:50,770 And then we always have the advantage 229 00:11:50,794 --> 00:11:54,129 of looking back on history and tracing. 230 00:11:54,214 --> 00:11:56,234 Historians could look back and say, "wait a minute. 231 00:11:56,258 --> 00:11:58,258 "all the cities with ports 232 00:11:58,343 --> 00:12:00,719 "that do a lot of trading were infected. 233 00:12:00,804 --> 00:12:04,723 And what were going to all these ports? Ships." 234 00:12:05,517 --> 00:12:07,851 The black death 235 00:12:07,936 --> 00:12:10,228 was spread by fleas that lived on rats. 236 00:12:10,272 --> 00:12:13,565 And wherever these rats went, the fleas went, 237 00:12:13,650 --> 00:12:16,192 and they bit people. That's what made them ill. 238 00:12:16,278 --> 00:12:19,090 The flea would actually vomit the bacteria 239 00:12:19,114 --> 00:12:21,322 onto the person's skin while biting them. 240 00:12:22,242 --> 00:12:24,492 The disease spreads to the body's lymph nodes 241 00:12:24,578 --> 00:12:26,202 and causes buboes, 242 00:12:26,246 --> 00:12:27,579 which are infected sores 243 00:12:27,622 --> 00:12:29,748 which get to be about the size of an egg. 244 00:12:29,791 --> 00:12:33,209 And they eventually burst and expel bloody pus. 245 00:12:33,253 --> 00:12:35,170 The body goes through 246 00:12:35,255 --> 00:12:37,172 such horrific and gruesome transformations 247 00:12:37,257 --> 00:12:41,259 that from the time you contract the bubonic plague until death 248 00:12:41,344 --> 00:12:43,344 can sometimes only be a matter of days. 249 00:12:43,430 --> 00:12:46,264 During the middle ages, many believed 250 00:12:46,308 --> 00:12:49,601 that demons were responsible for the black death. 251 00:12:49,686 --> 00:12:51,936 - - and people who were deemed 252 00:12:52,022 --> 00:12:54,856 to be wicked or unworthy 253 00:12:54,941 --> 00:12:56,274 were punished 254 00:12:56,318 --> 00:12:59,736 in hopes of driving the demons away. 255 00:13:01,907 --> 00:13:04,783 Many people believed 256 00:13:04,868 --> 00:13:08,495 that the source of this plague 257 00:13:08,580 --> 00:13:10,830 was caused by evil spirits, 258 00:13:10,916 --> 00:13:13,792 witchcraft and the like. 259 00:13:15,295 --> 00:13:17,003 The powers of the occult. 260 00:13:17,088 --> 00:13:20,089 And this led many people 261 00:13:20,175 --> 00:13:23,510 to seek out any type of expressions 262 00:13:23,595 --> 00:13:26,763 of the occult, witchcraft and the like... 263 00:13:28,391 --> 00:13:29,974 ...And to root it out 264 00:13:30,060 --> 00:13:33,436 in the attempt to placate god. 265 00:13:37,692 --> 00:13:39,796 Some were so convinced that the black death 266 00:13:39,820 --> 00:13:42,487 was a scourge brought by evil spirits, 267 00:13:42,572 --> 00:13:47,784 they were willing to scourge themselves. 268 00:13:49,079 --> 00:13:51,432 One common occurrence during the time of the black death 269 00:13:51,456 --> 00:13:55,542 was to see, uh, people that were called flagellants, which... 270 00:13:55,627 --> 00:13:57,647 They were under the belief that they were being punished 271 00:13:57,671 --> 00:14:00,797 by god for their sins, so they would publicly atone, 272 00:14:00,882 --> 00:14:03,299 and they would March through the town square, 273 00:14:03,385 --> 00:14:06,177 flogging themselves in the name of god. 274 00:14:11,101 --> 00:14:13,643 This flagellation movement really exploded. 275 00:14:13,728 --> 00:14:16,187 Whole towns flagellating themselves. 276 00:14:16,231 --> 00:14:18,565 Those that didn't were accused of being with the devil. 277 00:14:19,568 --> 00:14:23,903 Something else that came from the black death was 278 00:14:23,989 --> 00:14:27,448 the practice of selling holy relics. 279 00:14:27,534 --> 00:14:31,786 When the black death was decimating europe, 280 00:14:31,872 --> 00:14:34,372 the church were saying, 281 00:14:34,416 --> 00:14:35,915 "come to us, 282 00:14:36,001 --> 00:14:38,543 and we can cure you." 283 00:14:38,587 --> 00:14:40,295 the bones of a saint 284 00:14:40,380 --> 00:14:43,047 or something that had once belonged to a saint 285 00:14:43,091 --> 00:14:45,383 kept in these churches. They were called relics. 286 00:14:45,427 --> 00:14:47,488 And people believed that if they went there 287 00:14:47,512 --> 00:14:49,095 or close to such relics, 288 00:14:49,180 --> 00:14:51,222 prayed, that god may intervene 289 00:14:51,266 --> 00:14:53,266 and protect them from the plague. 290 00:14:53,351 --> 00:14:55,727 Now, they weren't curing anyone, 291 00:14:55,812 --> 00:14:59,397 but people were still flocking to the churches 292 00:14:59,441 --> 00:15:02,567 just on the hope that they could be cured. 293 00:15:03,570 --> 00:15:06,237 So, when we talk about the many lives 294 00:15:06,281 --> 00:15:08,698 that were lost during the black death, 295 00:15:08,742 --> 00:15:10,325 I think about a horror movie. 296 00:15:11,286 --> 00:15:13,764 Historians estimate that the black death 297 00:15:13,788 --> 00:15:17,540 wiped out anywhere from 50 to 200 million people, 298 00:15:17,626 --> 00:15:20,209 at least a third of europe's population. 299 00:15:20,253 --> 00:15:22,253 So it's little wonder 300 00:15:22,297 --> 00:15:24,756 that most people thought that something so destructive 301 00:15:24,841 --> 00:15:28,259 must have been some kind of punishment from god. 302 00:15:28,303 --> 00:15:31,679 But today, we have a much different understanding 303 00:15:31,765 --> 00:15:33,431 of this disease. 304 00:15:33,475 --> 00:15:35,266 We call it the black death, 305 00:15:35,352 --> 00:15:38,436 but it's-it's a bacteria called yersinia pestis. 306 00:15:38,521 --> 00:15:42,482 But it's not as dangerous as it was then. 307 00:15:42,567 --> 00:15:45,151 Now we have antibiotics. 308 00:15:45,236 --> 00:15:46,945 We can detect it. 309 00:15:47,030 --> 00:15:48,905 You know, you can treat it. 310 00:15:50,867 --> 00:15:52,575 In any case, 311 00:15:52,661 --> 00:15:56,079 yersinia pestis is still around today, 312 00:15:56,122 --> 00:15:58,706 which begs the question, 313 00:15:58,792 --> 00:16:00,249 is it possible 314 00:16:00,335 --> 00:16:02,961 to actually kill off a fatal disease 315 00:16:03,004 --> 00:16:04,295 once and for all? 316 00:16:04,339 --> 00:16:05,630 Perhaps the answer can be found 317 00:16:05,674 --> 00:16:07,924 by examining a deadly plague 318 00:16:07,968 --> 00:16:09,634 that, believe it or not, 319 00:16:09,678 --> 00:16:12,470 has been infecting humankind 320 00:16:12,514 --> 00:16:15,974 for more than 10,000 years. 321 00:16:22,857 --> 00:16:24,816 The valley of mexico. 322 00:16:29,531 --> 00:16:33,241 Spanish conquistadors led by hern�n cort�s 323 00:16:33,326 --> 00:16:36,911 arrive at tenochtitl�n, the capital of the aztec empire, 324 00:16:36,997 --> 00:16:39,455 bearing dreams of conquest 325 00:16:39,541 --> 00:16:42,166 and an insatiable desire for gold. 326 00:16:42,252 --> 00:16:47,338 But they also brought with them a lethal, infectious disease. 327 00:16:47,382 --> 00:16:49,465 Smallpox is introduced 328 00:16:49,551 --> 00:16:53,011 into the americas very dramatically 329 00:16:53,054 --> 00:16:54,115 at a specific point in time 330 00:16:54,139 --> 00:16:56,556 and alongside the european invasion. 331 00:16:56,641 --> 00:17:00,685 This is a tremendous sort of clash of civilizations, 332 00:17:00,729 --> 00:17:03,479 the likes of which the world had never seen before 333 00:17:03,565 --> 00:17:04,731 and will never see again. 334 00:17:04,816 --> 00:17:08,860 The single most deciding factor 335 00:17:08,903 --> 00:17:13,072 as to why native american civilizations fell so rapidly 336 00:17:13,158 --> 00:17:14,918 was the introduction of smallpox. 337 00:17:17,871 --> 00:17:20,371 So, smallpox is a virus. 338 00:17:20,415 --> 00:17:24,250 It causes these sort of irregularly spaced, 339 00:17:24,335 --> 00:17:26,878 pustule-y skin lesions 340 00:17:26,921 --> 00:17:28,379 and had a devastating effect 341 00:17:28,465 --> 00:17:31,841 on-on native americans, um, in the new world. 342 00:17:32,802 --> 00:17:37,055 In europe, most people had experienced smallpox. 343 00:17:37,098 --> 00:17:38,723 They had the scars, 344 00:17:38,767 --> 00:17:40,183 or they had it as children. 345 00:17:40,268 --> 00:17:43,519 But there was no immunity in the new world. 346 00:17:43,563 --> 00:17:45,688 There was no immunity among kids. 347 00:17:45,774 --> 00:17:47,899 There was no immunity among adults. 348 00:17:47,942 --> 00:17:51,027 And so, when this new disease came, 349 00:17:51,112 --> 00:17:53,696 everybody was vulnerable. 350 00:17:53,740 --> 00:17:56,115 And so it spread like wildfire. 351 00:17:57,410 --> 00:18:00,203 Although the exact numbers will never be known, 352 00:18:00,246 --> 00:18:02,163 many experts estimate 353 00:18:02,248 --> 00:18:05,666 that a staggering 95% of the indigenous population 354 00:18:05,752 --> 00:18:08,878 would eventually die from smallpox. 355 00:18:08,922 --> 00:18:11,214 But what's even more chilling 356 00:18:11,257 --> 00:18:13,883 is the fact that smallpox ran rampant 357 00:18:13,968 --> 00:18:16,260 for thousands of years. 358 00:18:16,304 --> 00:18:19,806 I am astounded 359 00:18:19,891 --> 00:18:23,059 by how far back smallpox goes. 360 00:18:23,103 --> 00:18:25,937 For most of human recorded history, 361 00:18:25,980 --> 00:18:27,772 we believe it's the same strain 362 00:18:27,857 --> 00:18:30,149 that was infecting one person after another, 363 00:18:30,235 --> 00:18:32,527 this human chain of infection. 364 00:18:32,612 --> 00:18:38,908 The egyptian pharaoh ramses v had scarring on his face 365 00:18:38,993 --> 00:18:41,744 that's consistent with smallpox. 366 00:18:44,791 --> 00:18:47,416 It is estimated that smallpox has killed 367 00:18:47,460 --> 00:18:49,961 between 300 and 500 million people 368 00:18:50,046 --> 00:18:53,840 in its more than 10,000-year existence. 369 00:18:53,925 --> 00:18:57,802 How did we finally beat it? 370 00:19:00,682 --> 00:19:03,349 Well, it just so happens that the cure for smallpox 371 00:19:03,434 --> 00:19:08,479 was discovered in a small english village in the 1790s. 372 00:19:08,523 --> 00:19:12,358 In the late 1700s, doctors were noticing 373 00:19:12,443 --> 00:19:16,612 that milkmaids did not seem to be affected by smallpox, 374 00:19:16,698 --> 00:19:21,325 and their complexions remained unscarred. 375 00:19:21,411 --> 00:19:25,413 And people were starting to make that connection 376 00:19:25,498 --> 00:19:29,000 that there might be immunity from catching 377 00:19:29,043 --> 00:19:33,171 a different kind of pox virus, cow pox. 378 00:19:33,214 --> 00:19:37,133 So milkmaids were exposed to the cow pox virus, 379 00:19:37,177 --> 00:19:39,218 probably got infected, 380 00:19:39,304 --> 00:19:42,180 and were then immune to smallpox. 381 00:19:44,017 --> 00:19:45,911 Edward jenner was an english physician, 382 00:19:45,935 --> 00:19:49,520 and decided to test this observation, 383 00:19:49,606 --> 00:19:52,815 and took a piece of an ulcer from a cow 384 00:19:52,859 --> 00:19:55,026 that was infected by cow pox, 385 00:19:55,069 --> 00:19:58,696 and gave it to an eight-year-old boy. 386 00:19:58,781 --> 00:20:01,657 And then, a little bit later, 387 00:20:01,743 --> 00:20:05,703 gave this little boy a dose of smallpox. 388 00:20:05,788 --> 00:20:10,374 Fortunately, the eight-year-old boy did not develop smallpox 389 00:20:10,418 --> 00:20:13,502 and was actually protected. 390 00:20:13,546 --> 00:20:16,130 Because it wasn't, like, a direct viral intake, 391 00:20:16,216 --> 00:20:19,967 you would get, like, a slightly lesser version of the disease. 392 00:20:20,053 --> 00:20:22,094 But because you had been exposed to it, 393 00:20:22,180 --> 00:20:24,722 you would, of course, then have immunity. 394 00:20:24,766 --> 00:20:26,702 So it was probably the first instance 395 00:20:26,726 --> 00:20:29,060 of a crude version of vaccination. 396 00:20:30,438 --> 00:20:33,689 As it turns out, edward jenner's revolutionary experiment 397 00:20:33,775 --> 00:20:36,651 is remembered today for its inspiration, 398 00:20:36,736 --> 00:20:39,570 its sheer audacity 399 00:20:39,614 --> 00:20:42,073 and because it provided a new defense 400 00:20:42,116 --> 00:20:43,699 against infectious disease, 401 00:20:43,743 --> 00:20:48,913 which we now refer to as "the vaccine." 402 00:20:48,998 --> 00:20:52,416 the word "vaccine" comes from the virus name "vaccinia," 403 00:20:52,502 --> 00:20:57,421 which was the virus that was the cow pox-derived virus 404 00:20:57,465 --> 00:21:00,716 that left people immune to smallpox. 405 00:21:00,802 --> 00:21:04,220 Vaccines prevent disease, 406 00:21:04,305 --> 00:21:07,265 and some vaccines can last for decades, 407 00:21:07,308 --> 00:21:11,602 and some vaccines need to be given every year. 408 00:21:11,646 --> 00:21:15,648 For smallpox, people had to get vaccinated every ten years. 409 00:21:16,943 --> 00:21:20,361 Vaccines are humanity's single greatest weapon 410 00:21:20,446 --> 00:21:22,280 against plagues. 411 00:21:22,365 --> 00:21:25,116 Rooted in science and not superstition, 412 00:21:25,159 --> 00:21:28,995 they provide a powerful way to fight outbreaks. 413 00:21:29,080 --> 00:21:31,497 The last naturally occurring case of smallpox 414 00:21:31,582 --> 00:21:35,626 was identified in 1979, and in 1980, 415 00:21:35,712 --> 00:21:37,503 the world health organization declared 416 00:21:37,588 --> 00:21:39,630 that smallpox was eradicated. 417 00:21:39,674 --> 00:21:43,009 So no longer spreading from person to person. 418 00:21:43,094 --> 00:21:47,346 Eradicating smallpox was the biggest public health victory 419 00:21:47,432 --> 00:21:50,433 in the history of the human race. 420 00:21:51,561 --> 00:21:54,645 The eradication of smallpox is the most famous use 421 00:21:54,731 --> 00:21:57,231 of a highly-effective vaccine, 422 00:21:57,317 --> 00:22:01,777 but there are some diseases that are harder to cure. 423 00:22:01,821 --> 00:22:03,988 There are viruses 424 00:22:04,032 --> 00:22:06,157 for which we have no vaccines at all, 425 00:22:06,242 --> 00:22:08,200 because they mutate too rapidly. 426 00:22:08,286 --> 00:22:11,454 And so, because viruses mutate, 427 00:22:11,539 --> 00:22:15,333 there's a certain limitation to what you can do with vaccines. 428 00:22:17,211 --> 00:22:19,420 The minute you get too confident, 429 00:22:19,505 --> 00:22:22,131 and you think that we defeated mother nature, 430 00:22:22,216 --> 00:22:25,176 somehow, it always finds a way to come back. 431 00:22:25,261 --> 00:22:27,553 Vaccines are one of mankind's 432 00:22:27,638 --> 00:22:29,805 greatest scientific triumphs. 433 00:22:29,849 --> 00:22:32,058 But not all medical recoveries 434 00:22:32,143 --> 00:22:34,143 can be easily explained by science. 435 00:22:34,187 --> 00:22:37,188 Sometimes, the body's reaction 436 00:22:37,273 --> 00:22:40,858 to an infection is so bizarre and so inexplicable 437 00:22:40,902 --> 00:22:44,362 that it can only be described as... 438 00:22:44,405 --> 00:22:50,201 Miraculous. 439 00:22:50,286 --> 00:22:52,787 July 4, 1863. 440 00:22:52,872 --> 00:22:55,247 Gettysburg, pennsylvania. 441 00:22:55,333 --> 00:22:57,144 On the morning after the bloodiest battle 442 00:22:57,168 --> 00:22:58,542 of the civil war, 443 00:22:58,628 --> 00:23:01,712 thousands of dead soldiers lay strewn 444 00:23:01,798 --> 00:23:04,006 across the blood-soaked farmland. 445 00:23:04,092 --> 00:23:08,677 But while the brutality of the civil war is well-documented, 446 00:23:08,763 --> 00:23:11,430 approximately two-thirds of the more 447 00:23:11,516 --> 00:23:13,766 than 600,000 deaths in the war 448 00:23:13,851 --> 00:23:17,812 weren't caused by injuries sustained on the battlefield, 449 00:23:17,897 --> 00:23:20,898 but rather... By disease. 450 00:23:23,569 --> 00:23:25,528 The civil war represents 451 00:23:25,571 --> 00:23:30,074 the last major conflict that, um, that humans experienced 452 00:23:30,159 --> 00:23:33,035 um, before the, sort of, the inception 453 00:23:33,079 --> 00:23:34,703 or the origins of germ theory. 454 00:23:34,747 --> 00:23:37,415 You can imagine the conditions 455 00:23:37,500 --> 00:23:40,543 that soldiers live in, crowded together, 456 00:23:40,628 --> 00:23:42,503 substandard sanitation. 457 00:23:42,588 --> 00:23:44,588 In some cases, 458 00:23:44,632 --> 00:23:47,258 open wounds that aren't being treated correctly. 459 00:23:47,301 --> 00:23:49,260 It's really gross. 460 00:23:49,303 --> 00:23:51,053 Everything smells terrible. 461 00:23:51,097 --> 00:23:53,597 Uh, these doctors aren't washing their aprons. 462 00:23:53,683 --> 00:23:57,601 They can't explain where they're getting these diseases from, 463 00:23:57,687 --> 00:23:59,478 how they may be spreading it. 464 00:23:59,564 --> 00:24:02,857 As uncontrollable infections ravaged 465 00:24:02,942 --> 00:24:05,943 both union and confederate encampments, 466 00:24:05,987 --> 00:24:09,405 soldiers and their doctors debated the cause 467 00:24:09,449 --> 00:24:11,115 of their afflictions. 468 00:24:11,159 --> 00:24:17,121 Many came to believe that the air itself was poisoned. 469 00:24:17,165 --> 00:24:19,123 When we talk about 470 00:24:19,167 --> 00:24:22,084 some of the deadliest viruses that we know, 471 00:24:22,170 --> 00:24:27,131 some of them get transmitted by respiratory droplets, the air. 472 00:24:27,175 --> 00:24:32,136 When you cough, when you sneeze, just by talking. 473 00:24:32,180 --> 00:24:36,307 So maybe they weren't too off by saying the air is bad. 474 00:24:37,226 --> 00:24:39,810 In the mid-nineteenth century, 475 00:24:39,896 --> 00:24:41,979 little was known about disease control 476 00:24:42,064 --> 00:24:45,316 or preventing the spread of germs. 477 00:24:45,401 --> 00:24:48,611 But as the scope of the war widened 478 00:24:48,696 --> 00:24:51,947 and the ferocity of infectious outbreaks resulted 479 00:24:51,991 --> 00:24:54,450 in even more horrific causalities, 480 00:24:54,494 --> 00:24:58,996 doctors were forced to expand their knowledge of diseases 481 00:24:59,081 --> 00:25:01,081 and how to contain them. 482 00:25:01,167 --> 00:25:03,083 They realize that 483 00:25:03,169 --> 00:25:06,170 maybe a barn isn't the best place to be doing 484 00:25:06,214 --> 00:25:09,298 amputations and open surgeries. 485 00:25:09,383 --> 00:25:11,842 So, as the war goes on, 486 00:25:11,928 --> 00:25:13,697 there's beginning to be an understanding 487 00:25:13,721 --> 00:25:15,346 of what medicine should be. 488 00:25:15,389 --> 00:25:16,972 Things like triage, 489 00:25:17,058 --> 00:25:20,601 things like an ambulance system, hospitals... 490 00:25:20,686 --> 00:25:22,539 These are all established during the civil war 491 00:25:22,563 --> 00:25:24,374 in the united states for the first time. 492 00:25:24,398 --> 00:25:27,191 In many ways, the civil war marked the beginning 493 00:25:27,276 --> 00:25:28,984 of medical science as we know it 494 00:25:29,028 --> 00:25:31,362 and the end of mankind's 495 00:25:31,405 --> 00:25:34,573 superstitious attitude towards disease. 496 00:25:34,659 --> 00:25:37,368 But there is one event on the battlefield 497 00:25:37,453 --> 00:25:40,996 that medical historians still struggle to explain to this day, 498 00:25:41,082 --> 00:25:44,375 because it simply defies understanding. 499 00:25:48,214 --> 00:25:52,550 April 7, 1862, hardin county, tennessee. 500 00:25:52,593 --> 00:25:56,053 Union and confederate forces square off 501 00:25:56,138 --> 00:25:58,055 in one of the bloodiest confrontations 502 00:25:58,140 --> 00:26:01,225 of the civil war... The battle of shiloh. 503 00:26:03,187 --> 00:26:06,063 After two days of vicious fighting... 504 00:26:08,401 --> 00:26:13,529 ...More than 20,000 men lie dead or dying. 505 00:26:14,657 --> 00:26:17,199 So, ulysses s. Grant is the commander 506 00:26:17,285 --> 00:26:18,554 of the union army at this battle. 507 00:26:18,578 --> 00:26:20,681 He went out, and looked over the battlefield, 508 00:26:20,705 --> 00:26:24,415 and he could see that there were so many soldiers who had been 509 00:26:24,458 --> 00:26:27,418 wounded and killed that he could have walked across one side 510 00:26:27,461 --> 00:26:28,877 of the battlefield to the other 511 00:26:28,963 --> 00:26:30,399 without ever touching the ground, 512 00:26:30,423 --> 00:26:33,424 walking from body to body to body. 513 00:26:33,467 --> 00:26:37,136 As night falls over the battlefield, 514 00:26:37,221 --> 00:26:40,222 many injured soldiers lie helpless, 515 00:26:40,266 --> 00:26:43,601 hoping to be rescued before their wounds become infected. 516 00:26:43,686 --> 00:26:47,730 What happens next is one of the enduring mysteries 517 00:26:47,815 --> 00:26:49,607 of the civil war. 518 00:26:49,650 --> 00:26:52,735 Soldiers are out between the lines, 519 00:26:52,820 --> 00:26:54,778 wounded during the course of the battle. 520 00:26:54,822 --> 00:26:57,072 It's cold at night. They're out there shivering. 521 00:26:57,116 --> 00:27:01,368 And they happen to look down at their shattered arm or leg, 522 00:27:01,454 --> 00:27:06,540 and they notice this soft, faint, bluish-greenish glow 523 00:27:06,626 --> 00:27:09,001 seeming to come off their wounds in the darkness. 524 00:27:09,086 --> 00:27:12,546 There was a connection that was being made amongst the soldiers 525 00:27:12,632 --> 00:27:16,592 that those who experienced this glowing wound effect 526 00:27:16,636 --> 00:27:19,303 seemed to have better outcomes 527 00:27:19,347 --> 00:27:21,722 when they went back to the field hospital, and it seemed 528 00:27:21,807 --> 00:27:25,309 as though their wounds may not have been as infected. 529 00:27:25,353 --> 00:27:29,938 They termed this bluish-green glow 530 00:27:29,982 --> 00:27:32,441 angel's glow. Why? 531 00:27:32,526 --> 00:27:35,611 Because, to them, it looked like a halo. 532 00:27:35,655 --> 00:27:38,322 Mystical light surrounding them. 533 00:27:38,366 --> 00:27:40,491 So, it was a way of them thinking that god 534 00:27:40,534 --> 00:27:43,494 or the angels were protecting these particular soldiers. 535 00:27:43,579 --> 00:27:46,872 Was the so-called angel's glow 536 00:27:46,957 --> 00:27:49,041 a type of divine intervention 537 00:27:49,126 --> 00:27:53,253 that somehow protected certain soldiers from deadly infections? 538 00:27:53,339 --> 00:27:57,466 Perhaps. But recently, a new theory has surfaced... 539 00:27:57,551 --> 00:27:59,802 One that suggests this phenomenon 540 00:27:59,845 --> 00:28:05,099 may have had a more conventional explanation. 541 00:28:05,184 --> 00:28:08,268 It wasn't until many years, like 150 years later, 542 00:28:08,354 --> 00:28:12,523 that a 17-year-old high school student visited shiloh, 543 00:28:12,608 --> 00:28:14,983 and he decided for his science project 544 00:28:15,027 --> 00:28:17,861 to research bacterium that glows. 545 00:28:17,947 --> 00:28:21,699 And they were able to find out that there was a bacteria 546 00:28:21,784 --> 00:28:24,702 that would emit some sort of parasitic worm. 547 00:28:24,745 --> 00:28:27,663 It would get into the veins, and then it would glow. 548 00:28:27,748 --> 00:28:30,874 Could the angel's glow 549 00:28:30,918 --> 00:28:33,544 really have been a sign of a type of bacteria, 550 00:28:33,587 --> 00:28:36,004 rather than guardian angels? 551 00:28:36,090 --> 00:28:39,842 And if so, could this bacteria have actually been responsible 552 00:28:39,927 --> 00:28:43,971 for saving the lives of the wounded soldiers? 553 00:28:44,056 --> 00:28:46,181 Presumably, what happened with those soldiers 554 00:28:46,225 --> 00:28:47,891 with the angel's glow 555 00:28:47,935 --> 00:28:51,228 is that those bacteria were actually infecting their wounds. 556 00:28:51,272 --> 00:28:54,857 And because those bacteria exude a lot of antibacterial 557 00:28:54,900 --> 00:28:58,235 and antimicrobial compounds, they actually reduce the level 558 00:28:58,279 --> 00:28:59,695 of infection in the soldiers 559 00:28:59,780 --> 00:29:02,448 that they, that they, uh, colonized. 560 00:29:03,284 --> 00:29:04,469 The bacteria theory 561 00:29:04,493 --> 00:29:07,578 is the best scientific explanation we have 562 00:29:07,663 --> 00:29:11,039 for what caused the angel's glow. 563 00:29:11,125 --> 00:29:13,167 If this incredible theory is true, 564 00:29:13,252 --> 00:29:16,170 then it seems that some forms of bacteria 565 00:29:16,255 --> 00:29:19,923 can actually help us in the fight against disease. 566 00:29:19,967 --> 00:29:22,593 But the soldiers whose lives were saved 567 00:29:22,636 --> 00:29:26,764 at the battle of shiloh believed that what healed them 568 00:29:26,807 --> 00:29:30,100 could only have been sent from heaven. 569 00:29:30,144 --> 00:29:31,788 We can't know what those soldiers experienced 570 00:29:31,812 --> 00:29:35,105 out there on the battlefield between the lines. 571 00:29:35,191 --> 00:29:37,775 They're in the dark, they're suffering from shock. 572 00:29:37,818 --> 00:29:39,777 Who's to say that they didn't experience that 573 00:29:39,820 --> 00:29:42,571 or that they did experience that? 574 00:29:44,074 --> 00:29:47,743 Guardian angels, reaching down to comfort 575 00:29:47,787 --> 00:29:52,247 and even cure dying soldiers during the american civil war? 576 00:29:52,291 --> 00:29:55,417 To some it sounds like pure fantasy. 577 00:29:55,503 --> 00:29:58,045 But to others, especially those 578 00:29:58,130 --> 00:30:01,381 who've had their own close calls with death, 579 00:30:01,467 --> 00:30:05,969 there's no doubt that such a notion is entirely plausible. 580 00:30:06,055 --> 00:30:08,639 When dealing with deadly diseases, 581 00:30:08,724 --> 00:30:11,183 it's hard to be certain of pretty much anything. 582 00:30:11,268 --> 00:30:15,103 Not only do we often know very little 583 00:30:15,147 --> 00:30:17,105 about how to cure an illness, 584 00:30:17,191 --> 00:30:20,609 we know even less about where an illness comes from. 585 00:30:20,653 --> 00:30:22,986 For instance, what if I told you 586 00:30:23,030 --> 00:30:26,782 that what we commonly refer to as the spanish flu 587 00:30:26,867 --> 00:30:31,662 didn't come from Spain at all, but from a remote army base... 588 00:30:33,374 --> 00:30:35,332 ...In kansas? 589 00:30:46,554 --> 00:30:48,929 At the height of world war I, 590 00:30:49,014 --> 00:30:52,683 more than 50 years after the end of the american civil war, 591 00:30:52,768 --> 00:30:56,645 soldiers from more than 30 nations are engaged 592 00:30:56,689 --> 00:30:59,356 in trench warfare all over europe... 593 00:31:00,776 --> 00:31:04,361 ...And a new, unexpected enemy emerges... 594 00:31:04,405 --> 00:31:07,364 ...The spanish flu. 595 00:31:08,409 --> 00:31:09,719 Europe is awash 596 00:31:09,743 --> 00:31:12,452 in the influenza virus. 597 00:31:12,538 --> 00:31:16,540 They had a massive outbreak of influenza, 598 00:31:16,584 --> 00:31:19,334 and these soldiers serving at the front lines 599 00:31:19,420 --> 00:31:22,546 are directly impacted on both sides of the conflict. 600 00:31:22,590 --> 00:31:25,966 - -the symptoms were pretty horrific, 601 00:31:26,051 --> 00:31:27,946 and so these soldiers were not capable of performing 602 00:31:27,970 --> 00:31:30,888 their duties, and many of them actually die of the disease. 603 00:31:32,391 --> 00:31:35,642 We're used to the flu, but the 1918 flu 604 00:31:35,728 --> 00:31:39,521 had more severe symptoms and lingering effects. 605 00:31:40,774 --> 00:31:43,025 When the flu first started spreading, 606 00:31:43,110 --> 00:31:46,236 their skin turned blue. 607 00:31:46,322 --> 00:31:49,239 They just had no oxygen in their blood. 608 00:31:49,283 --> 00:31:52,910 It was not uncommon for people to lose all their hair. 609 00:31:52,953 --> 00:31:57,247 It was not uncommon to have neurological side effects. 610 00:31:58,500 --> 00:32:00,792 The 1918 influenza strain 611 00:32:00,878 --> 00:32:04,296 caused an incredibly high fever, it caused coughing. 612 00:32:04,381 --> 00:32:08,216 In many cases, patients' lungs would fill with fluid 613 00:32:08,302 --> 00:32:10,102 as this virus is taking over their body. 614 00:32:10,179 --> 00:32:13,305 That would cause an immune system overreaction 615 00:32:13,390 --> 00:32:15,265 and they would essentially drown. 616 00:32:16,810 --> 00:32:18,204 Medics on the front lines, 617 00:32:18,228 --> 00:32:20,020 prepared for the ravages of war, 618 00:32:20,105 --> 00:32:24,232 look on in horror as young, healthy soldiers 619 00:32:24,318 --> 00:32:26,193 begin to die within days, 620 00:32:26,278 --> 00:32:29,905 or even hours of showing symptoms. 621 00:32:29,949 --> 00:32:34,743 The spanish flu was caused by, um, an h1n1 influenza virus. 622 00:32:34,828 --> 00:32:37,871 And the particular strain of the h1n1 virus 623 00:32:37,957 --> 00:32:40,624 was a little unusual amongst influenza viruses 624 00:32:40,668 --> 00:32:43,961 in that it was much more contagious, it was much easier 625 00:32:44,004 --> 00:32:46,088 to expel and spread between people. 626 00:32:46,131 --> 00:32:49,049 In 1918, we still really were 627 00:32:49,134 --> 00:32:51,635 sort of incapable of stopping its spread. 628 00:32:51,679 --> 00:32:54,221 This was right at the end of world war I, 629 00:32:54,306 --> 00:32:57,516 and so soldiers were, of course, kept in close quarters 630 00:32:57,601 --> 00:32:59,059 and barracks together. 631 00:32:59,103 --> 00:33:02,479 And then, also, people were sort of moving around the world 632 00:33:02,523 --> 00:33:04,167 more than they probably normally would have been 633 00:33:04,191 --> 00:33:05,649 sort of traveling. 634 00:33:05,734 --> 00:33:08,652 Um, and so those were some of the factors 635 00:33:08,696 --> 00:33:10,821 that caused it to spread really rapidly. 636 00:33:10,864 --> 00:33:14,408 Since finding a cure for a mysterious virus 637 00:33:14,493 --> 00:33:17,452 in the midst of a world war is a difficult, 638 00:33:17,496 --> 00:33:19,496 if not impossible undertaking, 639 00:33:19,581 --> 00:33:23,417 both the central powers and the allied powers 640 00:33:23,502 --> 00:33:25,335 decided the best course of action 641 00:33:25,379 --> 00:33:29,798 was to downplay the threat posed by the disease. 642 00:33:29,883 --> 00:33:33,468 In fact, the 1918 flu is called the spanish flu 643 00:33:33,554 --> 00:33:36,805 not because it came from Spain, but because, 644 00:33:36,890 --> 00:33:40,308 initially, Spain was the only country willing 645 00:33:40,352 --> 00:33:42,352 to acknowledge its existence. 646 00:33:45,524 --> 00:33:47,752 The reason we think of it as the spanish flu 647 00:33:47,776 --> 00:33:50,652 is because Spain had a free press at that time, 648 00:33:50,738 --> 00:33:54,031 and the rest of the world did not. 649 00:33:54,074 --> 00:33:56,783 Spain was not involved in world war I, 650 00:33:56,869 --> 00:34:00,370 and their king ended up getting the 1918 flu. 651 00:34:00,456 --> 00:34:02,225 So it was a matter of national interest, 652 00:34:02,249 --> 00:34:06,084 and most americans learned of the flu 653 00:34:06,170 --> 00:34:08,211 from the spanish papers. 654 00:34:10,716 --> 00:34:14,384 The so-called spanish flu is estimated to have infected 655 00:34:14,428 --> 00:34:17,721 one third of the world's population at the time, 656 00:34:17,765 --> 00:34:19,723 roughly 500 million people. 657 00:34:19,808 --> 00:34:23,310 But while the press created a lasting nickname 658 00:34:23,395 --> 00:34:24,811 for the 1918 flu, 659 00:34:24,897 --> 00:34:29,066 some researchers have suggested that it actually originated 660 00:34:29,151 --> 00:34:32,569 in the heartland of the united states. 661 00:34:36,658 --> 00:34:38,909 March 4, 1918. 662 00:34:38,994 --> 00:34:40,994 Fort riley, kansas. 663 00:34:41,080 --> 00:34:46,416 Before the so-called spanish flu outbreak was reported in europe, 664 00:34:46,502 --> 00:34:50,754 a private at this remote army base in the united states 665 00:34:50,798 --> 00:34:54,925 starts to feel ill. 666 00:34:54,968 --> 00:34:58,428 In March of 1918, an army private named albert gitchell... 667 00:34:58,472 --> 00:35:00,597 He's a cook with the army... 668 00:35:00,641 --> 00:35:02,744 He reports symptoms, so he goes to the hospital. 669 00:35:02,768 --> 00:35:05,018 Uh, he's sick, he's-he's not feeling well. 670 00:35:05,104 --> 00:35:06,831 He's got a bit of a cough, bit of a fever. 671 00:35:06,855 --> 00:35:09,606 In the end, he ultimately goes in to work, 672 00:35:09,691 --> 00:35:13,110 feeding all of these soldiers in this army camp. 673 00:35:13,153 --> 00:35:17,030 In the weeks that follow, the members of this camp 674 00:35:17,116 --> 00:35:20,742 come down with a pretty nasty flu strain. 675 00:35:20,786 --> 00:35:24,704 And there are no other outbreaks similar to this at this point, 676 00:35:24,790 --> 00:35:28,500 which suggests that this outbreak is starting 677 00:35:28,585 --> 00:35:31,086 at that camp, and potentially with that soldier. 678 00:35:32,381 --> 00:35:36,967 There were 1,127 cases just at fort riley itself, 679 00:35:37,010 --> 00:35:38,635 and 46 people died. 680 00:35:38,679 --> 00:35:40,490 So all these soldiers at fort riley are thinking 681 00:35:40,514 --> 00:35:43,807 they just had a bad cold, or maybe even a mild flu. 682 00:35:43,892 --> 00:35:46,434 They were eventually all put on trains, 683 00:35:46,478 --> 00:35:47,997 which spread all over the country 684 00:35:48,021 --> 00:35:49,187 going to various ports. 685 00:35:49,273 --> 00:35:50,667 And then they were all shipped off to europe 686 00:35:50,691 --> 00:35:52,315 to fight in the war. 687 00:35:52,401 --> 00:35:56,319 Many scientist now believe that army private albert gitchell 688 00:35:56,405 --> 00:36:00,490 was the first man to contract the 1918 flu. 689 00:36:00,534 --> 00:36:02,951 Gitchell spread it to his fellow servicemen 690 00:36:03,036 --> 00:36:04,619 when he served them food. 691 00:36:04,705 --> 00:36:06,788 And soldiers then were sent overseas 692 00:36:06,874 --> 00:36:09,958 to fight in the war, and they unwittingly 693 00:36:10,002 --> 00:36:12,002 spread the disease around the globe. 694 00:36:12,087 --> 00:36:15,797 But of course that explanation is only a theory. 695 00:36:15,883 --> 00:36:20,302 The situation fits the epidemiology, 696 00:36:20,387 --> 00:36:22,846 the number of people who got sick afterwards. 697 00:36:22,890 --> 00:36:26,016 But whether we will ever know for sure 698 00:36:26,101 --> 00:36:28,351 who patient zero was, 699 00:36:28,395 --> 00:36:31,062 or whether it absolutely came from kansas, 700 00:36:31,148 --> 00:36:33,356 it's hard to be absolutely sure. 701 00:36:33,400 --> 00:36:36,026 It's really hard to learn where any virus starts, 702 00:36:36,069 --> 00:36:39,821 where any pandemic starts, because you're not recording 703 00:36:39,865 --> 00:36:41,865 everywhere all the time, 704 00:36:41,909 --> 00:36:43,491 and having the scientific tools in place 705 00:36:43,535 --> 00:36:45,035 to be able to detect it. 706 00:36:47,122 --> 00:36:49,100 The great mystery of any of these pandemics 707 00:36:49,124 --> 00:36:52,209 or public health crises is where did it start? 708 00:36:52,252 --> 00:36:53,730 And, ultimately, why did it start? 709 00:36:53,754 --> 00:36:57,005 And what were the circumstances that allowed that to happen? 710 00:36:57,090 --> 00:36:59,883 It's the story of how we interact with one another, 711 00:36:59,968 --> 00:37:02,844 and how we spread diseases amongst each other. 712 00:37:02,930 --> 00:37:05,972 If you track that and you find that out, 713 00:37:06,058 --> 00:37:09,226 we could prevent it happening again in the future. 714 00:37:12,272 --> 00:37:15,815 The spanish flu outbreak lasted for three long years 715 00:37:15,901 --> 00:37:19,653 and killed an estimated 50 million people 716 00:37:19,738 --> 00:37:24,157 before society finally developed enough collective immunity 717 00:37:24,243 --> 00:37:26,952 for the virus to die out. 718 00:37:27,037 --> 00:37:30,914 History shows us that no matter how lethal a disease may be, 719 00:37:30,958 --> 00:37:34,334 humankind has always found a way to endure it, 720 00:37:34,419 --> 00:37:37,170 whether by employing medical breakthroughs 721 00:37:37,256 --> 00:37:39,381 or sheer patience. 722 00:37:39,466 --> 00:37:42,801 But what kind of illnesses will we have to face in the future? 723 00:37:42,886 --> 00:37:44,886 Could they be different than 724 00:37:44,930 --> 00:37:46,888 what we've experienced in the past? 725 00:37:46,974 --> 00:37:51,559 And might they come to our planet from another world? 726 00:37:59,444 --> 00:38:01,506 British astronomer sir fred hoyle 727 00:38:01,530 --> 00:38:05,573 publishes a book titled astronomical origins of life: 728 00:38:05,659 --> 00:38:08,785 Steps towards panspermia. 729 00:38:08,829 --> 00:38:11,496 In it, hoyle investigates the controversial theory 730 00:38:11,581 --> 00:38:14,082 of panspermia, which suggests that 731 00:38:14,167 --> 00:38:17,961 life on earth did not originate here 732 00:38:18,005 --> 00:38:20,505 but rather in space, 733 00:38:20,590 --> 00:38:23,091 and that asteroids carried the microbial 734 00:38:23,176 --> 00:38:25,969 building blocks of dna to our planet. 735 00:38:29,141 --> 00:38:31,035 You cannot dismiss the possibility 736 00:38:31,059 --> 00:38:33,727 that maybe life came from outer space. 737 00:38:33,812 --> 00:38:37,647 That we were seeded. Seeded by asteroids or comets 738 00:38:37,733 --> 00:38:40,066 that then put their organic materials 739 00:38:40,152 --> 00:38:42,485 onto the planet earth. 740 00:38:42,529 --> 00:38:45,280 And so there's a new theory in astronomy that says that 741 00:38:45,365 --> 00:38:47,532 the solar system is like a ping-pong game 742 00:38:47,617 --> 00:38:50,702 with meteorites carrying microbial lifeforms, 743 00:38:50,787 --> 00:38:53,747 going back and forth between venus, mars, 744 00:38:53,832 --> 00:38:55,957 the earth and the moon. 745 00:38:56,043 --> 00:38:59,002 This has given momentum to the panspermia theory. 746 00:39:00,339 --> 00:39:02,650 Some scientists have suggested that if the theory 747 00:39:02,674 --> 00:39:04,341 of panspermia is true, 748 00:39:04,426 --> 00:39:08,762 then it's possible that extraterrestrial viruses 749 00:39:08,847 --> 00:39:12,640 could also travel here, bringing with them diseases 750 00:39:12,726 --> 00:39:14,392 that would be much different 751 00:39:14,478 --> 00:39:17,520 from the ones that exist on earth. 752 00:39:17,606 --> 00:39:19,334 When you think about the core elements 753 00:39:19,358 --> 00:39:22,484 of viral plagues... those are the four genetic codes, 754 00:39:22,569 --> 00:39:25,195 dna or rna within a protein shell... 755 00:39:25,280 --> 00:39:27,781 That's something that's easier to imagine being stable 756 00:39:27,866 --> 00:39:29,532 deep inside an asteroid, and safe. 757 00:39:29,618 --> 00:39:31,951 And so any sort of virus or plague, 758 00:39:32,037 --> 00:39:33,953 you can imagine them starting from 759 00:39:34,039 --> 00:39:36,623 one of these asteroid events. 760 00:39:36,708 --> 00:39:40,710 A space plague is a leap into the unknown. 761 00:39:40,754 --> 00:39:43,713 We have no way of knowing what kinds of dna, 762 00:39:43,799 --> 00:39:47,384 or maybe a modified dna version exists in outer space. 763 00:39:48,678 --> 00:39:53,056 We have never seen other kinds of viruses from outer space 764 00:39:53,100 --> 00:39:55,850 that can infect earthlings. 765 00:39:55,936 --> 00:39:58,186 So right now we simply don't know the answer. 766 00:39:58,271 --> 00:40:01,439 I think if a plague came from outer space, 767 00:40:01,525 --> 00:40:03,900 just like the way some of the plagues we know 768 00:40:03,944 --> 00:40:06,403 jump from animals to humans, suddenly, 769 00:40:06,446 --> 00:40:09,989 any sudden change in the viruses 770 00:40:10,075 --> 00:40:12,409 or bacteria that are attacking you as a human, 771 00:40:12,494 --> 00:40:15,745 your immune system will not have a defense to, most likely. 772 00:40:15,789 --> 00:40:17,934 These dramatic events, whether it's from space 773 00:40:17,958 --> 00:40:20,333 or a sudden jumping from animals to humans, 774 00:40:20,419 --> 00:40:23,336 are the reason these plagues can be so devastating. 775 00:40:23,422 --> 00:40:26,923 A plague from outer space? 776 00:40:27,008 --> 00:40:29,217 While that may seem like a far-fetched notion, 777 00:40:29,302 --> 00:40:34,055 it's a possibility that science must be prepared for. 778 00:40:34,141 --> 00:40:36,422 There are always these viruses out there, 779 00:40:36,476 --> 00:40:37,870 these things that we can't explain. 780 00:40:37,894 --> 00:40:41,312 It's important for us to always be vigilant, to be aware 781 00:40:41,398 --> 00:40:43,251 and to have our public health authorities 782 00:40:43,275 --> 00:40:44,732 always on the lookout. 783 00:40:44,818 --> 00:40:46,129 So we can never put our guard down. 784 00:40:46,153 --> 00:40:48,319 Hopefully, the faster we are 785 00:40:48,405 --> 00:40:50,613 and the better we are at bioengineering, 786 00:40:50,699 --> 00:40:53,741 the faster we can make vaccines and countermeasures. 787 00:40:53,827 --> 00:40:56,619 It's key to have them so that we can make ways 788 00:40:56,705 --> 00:40:58,037 to protect ourselves. 789 00:40:58,123 --> 00:41:01,207 Preparing for any disease is complex, 790 00:41:01,293 --> 00:41:06,254 and it requires a lot of, um, mobilization of government, 791 00:41:06,339 --> 00:41:09,841 public health, and the science to be able to figure out 792 00:41:09,926 --> 00:41:13,052 what happened, and to prevent it from happening again. 793 00:41:13,138 --> 00:41:17,265 To be able to halt transmission of this disease, whatever it is. 794 00:41:17,350 --> 00:41:20,351 It becomes a detective story as well. 795 00:41:20,437 --> 00:41:23,354 You need to figure out where it came from 796 00:41:23,440 --> 00:41:25,356 and how to attribute the disease. 797 00:41:25,442 --> 00:41:29,194 It's a mystery that our lives depend on, 798 00:41:29,279 --> 00:41:31,404 and we need people to be working on that 799 00:41:31,490 --> 00:41:33,656 and thinking about that. 800 00:41:33,700 --> 00:41:37,660 Perhaps what makes deadly diseases so frightening 801 00:41:37,704 --> 00:41:40,914 is that we never know when they're going to strike next. 802 00:41:40,999 --> 00:41:44,334 And that uncertainty is also what forces us 803 00:41:44,377 --> 00:41:48,296 to ask ourselves are we really safe? 804 00:41:48,381 --> 00:41:52,217 Well, the truth is that only time will tell. 805 00:41:52,302 --> 00:41:54,636 Which means that, at least for now, 806 00:41:54,721 --> 00:41:59,265 these questions will remain unexplained.63170

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