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These are the user uploaded subtitles that are being translated: 1 00:00:16,666 --> 00:00:19,867 We can't both shower at the same time, Lea. 2 00:00:19,902 --> 00:00:22,503 One of us would block the steam of water for the other. 3 00:00:22,605 --> 00:00:24,905 Oh, Shaun, this is not for the purpose of cleanliness. 4 00:00:24,974 --> 00:00:27,574 This is for the purpose of having sex with you. 5 00:00:29,178 --> 00:00:30,778 Oh. 6 00:00:30,880 --> 00:00:32,312 N-No. No. 7 00:00:32,381 --> 00:00:34,815 It would be inconvenient, possibly dangerous. 8 00:00:34,884 --> 00:00:37,084 Soap might get into difficult places. 9 00:00:37,153 --> 00:00:38,619 If we leaned against the shower handle, 10 00:00:38,688 --> 00:00:39,653 we could scald ourselves. 11 00:00:39,721 --> 00:00:42,056 Bottles could be disarranged. 12 00:00:42,124 --> 00:00:43,824 It was just a thought. 13 00:00:43,926 --> 00:00:45,793 It was a bad thought. 14 00:00:45,895 --> 00:00:46,894 I'm surprised. 15 00:00:46,963 --> 00:00:48,495 You're such an intelligent person. 16 00:00:50,838 --> 00:00:53,372 I'll... reset your alarm. 17 00:00:57,044 --> 00:00:59,412 It's a three-day weekend and a full moon. 18 00:00:59,480 --> 00:01:00,913 People are gonna do stupid things. 19 00:01:00,982 --> 00:01:03,816 I'm asking everyone to take an extra trauma call in the E.R. 20 00:01:03,885 --> 00:01:05,884 Make yourselves available if you're needed. 21 00:01:05,986 --> 00:01:07,820 Questions? 22 00:01:08,679 --> 00:01:10,512 How'd you get the bruise? 23 00:01:10,581 --> 00:01:11,747 First casualty of the full moon. 24 00:01:11,849 --> 00:01:13,114 I smacked my head on a cupboard door 25 00:01:13,184 --> 00:01:14,583 when I was reaching for my coffee mug. 26 00:01:14,685 --> 00:01:15,784 Any other questions? 27 00:01:15,852 --> 00:01:18,853 Why is there a Subaru in your parking space? 28 00:01:18,922 --> 00:01:20,321 Because it's my car. 29 00:01:20,391 --> 00:01:21,323 You have a car? 30 00:01:21,392 --> 00:01:22,291 You're gonna be seeing a lot of it. 31 00:01:22,393 --> 00:01:23,291 I sold the Ducati. 32 00:01:23,360 --> 00:01:24,259 What? No. 33 00:01:24,328 --> 00:01:25,460 It just wasn't practical. 34 00:01:25,529 --> 00:01:26,661 Is it already gone? Because... 35 00:01:26,764 --> 00:01:29,063 A guy from Craigslist snatched it up. 36 00:01:29,166 --> 00:01:32,033 Any other questions... not dealing with the bike? 37 00:01:33,937 --> 00:01:35,670 It wasn't that much of a bruise. 38 00:01:36,807 --> 00:01:39,074 But the doctor at the ski resort told us 39 00:01:39,143 --> 00:01:40,709 I might develop a hematoma? 40 00:01:40,778 --> 00:01:43,745 It's not unusual, but it'll need to be drained. 41 00:01:44,334 --> 00:01:47,135 I see you were treated for melanoma six years ago, 42 00:01:47,204 --> 00:01:49,104 and, more recently, breast cancer. 43 00:01:49,205 --> 00:01:50,604 Hence the ski trip. 44 00:01:50,707 --> 00:01:52,741 A celebration. 45 00:01:52,809 --> 00:01:56,272 One year cancer-free. Also five years cancer-free. 46 00:01:57,514 --> 00:02:01,349 I don't suppose a long needle will be involved in this? 47 00:02:01,451 --> 00:02:03,284 Your hematoma extends pretty deep, 48 00:02:03,353 --> 00:02:04,853 so the needle will have to be long. 49 00:02:04,921 --> 00:02:06,487 But it's over quickly. 50 00:02:07,459 --> 00:02:09,324 Sorry, I have to intervene before this deal goes south. 51 00:02:09,426 --> 00:02:12,928 You don't mind if I step out? 52 00:02:12,997 --> 00:02:15,530 Would you like us to wait for your husband to come back? 53 00:02:15,633 --> 00:02:17,299 No. 54 00:02:17,401 --> 00:02:18,533 Let's go ahead. 55 00:02:22,173 --> 00:02:24,040 How do you get frostbite in San Jose? 56 00:02:24,142 --> 00:02:25,274 Cryotherapy accident. 57 00:02:25,343 --> 00:02:27,109 I stayed in the booth a little too long. 58 00:02:27,178 --> 00:02:29,178 I was going to stand outside for the full three minutes, 59 00:02:29,246 --> 00:02:30,812 - but he said... - I said, "No need." 60 00:02:30,915 --> 00:02:32,648 I'd set the stopwatch on my phone... 61 00:02:32,717 --> 00:02:35,284 after which, my thoughts immediately drifted, and... 62 00:02:35,352 --> 00:02:38,128 I came back to find him frozen in carbonite. 63 00:02:38,572 --> 00:02:40,673 You know, I'm more worried about the fever. 64 00:02:40,775 --> 00:02:43,006 Was the cryotherapy meant to treat something? 65 00:02:43,106 --> 00:02:44,290 No. Routine self-care. 66 00:02:44,390 --> 00:02:46,657 We've made life extension part of our health regime... 67 00:02:46,757 --> 00:02:48,780 supplements, meditation, exercise. 68 00:02:49,472 --> 00:02:51,138 Three of my gaming apps have gone viral. 69 00:02:51,207 --> 00:02:53,974 I'm lucky enough to afford basically whatever I want, 70 00:02:54,076 --> 00:02:56,110 so I spend it on my health. 71 00:02:56,212 --> 00:02:59,480 No, I figure fever, must be an infection. 72 00:02:59,582 --> 00:03:02,450 Well, I know that frostbite can make you vulnerable. 73 00:03:02,552 --> 00:03:07,488 It just... It didn't seem severe enough to... 74 00:03:07,590 --> 00:03:10,190 Oh, sorry. I feel a little queasy. 75 00:03:11,394 --> 00:03:12,359 Wyatt. 76 00:03:21,838 --> 00:03:23,471 I need a medical transport team, stat. 77 00:03:23,573 --> 00:03:25,706 Perforated bowel. He needs immediate surgery. 79 00:03:35,819 --> 00:03:37,885 No. No. Why do people hate wind farms? 80 00:03:37,987 --> 00:03:39,921 Everyone thinks they're noisy. 81 00:03:40,023 --> 00:03:41,556 This could make a turbine sound as quiet 82 00:03:41,658 --> 00:03:43,057 as a page turning in a library. 83 00:03:43,159 --> 00:03:44,525 That's not worth our investing in? 84 00:03:44,627 --> 00:03:46,093 Did you even look... Hold on. 85 00:03:46,195 --> 00:03:47,962 Anything I need to know? 86 00:03:48,064 --> 00:03:49,130 Hematoma's drained. 87 00:03:49,231 --> 00:03:51,031 We're sending a sample to Pathology... routine. 88 00:03:51,133 --> 00:03:52,399 Should have it back sometime tomorrow. 89 00:03:52,501 --> 00:03:53,439 Thank you. 90 00:03:54,904 --> 00:03:57,237 I couldn't help overhearing a little. 91 00:03:57,340 --> 00:04:00,107 Are you a venture capitalist? 92 00:04:00,209 --> 00:04:02,343 The only people who ask me if I'm a VC 93 00:04:02,445 --> 00:04:05,112 are people who want a VC to invest in their project. 94 00:04:06,916 --> 00:04:10,885 Maybe, after we get your wife healthy again, we could talk? 95 00:04:10,987 --> 00:04:11,886 Call whenever you're ready. 96 00:04:11,988 --> 00:04:13,620 My life is listening to ideas. 97 00:04:13,722 --> 00:04:15,155 If it's good, I'll run it by my two partners. 98 00:04:15,257 --> 00:04:16,356 If it's really good, 99 00:04:16,458 --> 00:04:18,525 we'll take a 30% equity position in your company. 100 00:04:20,864 --> 00:04:22,229 Yeah. 101 00:04:22,331 --> 00:04:24,565 Yeah, you're the one who wanted us to get into clean technology. 102 00:04:26,736 --> 00:04:28,669 I think I've been asked out on a date. 103 00:04:28,769 --> 00:04:29,869 _ 104 00:04:30,673 --> 00:04:31,806 Nice. 105 00:04:31,908 --> 00:04:32,940 No, I work with him. 106 00:04:33,042 --> 00:04:34,875 - Hasn't stopped you before. - I supervise him. 107 00:04:34,977 --> 00:04:35,943 Schedules can be changed. 108 00:04:36,045 --> 00:04:37,377 He's polyamorous. 109 00:04:37,479 --> 00:04:40,781 Unless he also texted you a ring, it's just a date. 110 00:04:40,883 --> 00:04:42,416 And you need to get out more. 111 00:04:43,920 --> 00:04:45,019 So do I. 112 00:04:50,760 --> 00:04:53,795 You want to take down the splenocolic ligament. 113 00:04:53,897 --> 00:04:56,798 Just don't nick the inferior mesenteric artery. 114 00:04:56,900 --> 00:05:00,635 I feel the I.M.A. under my finger. 115 00:05:00,737 --> 00:05:03,004 Placing the stapler. 116 00:05:03,105 --> 00:05:05,072 And cutting. 117 00:05:05,174 --> 00:05:06,707 I voted "approve." 118 00:05:09,912 --> 00:05:11,312 Disapprove. 119 00:05:11,414 --> 00:05:13,147 No opinion. 120 00:05:13,249 --> 00:05:14,148 There's a poll? 121 00:05:14,250 --> 00:05:16,550 Yes... about shower sex. 122 00:05:16,652 --> 00:05:19,286 I know it's wrong to discuss shower sex at work, 123 00:05:19,388 --> 00:05:20,988 so I did a poll instead. 124 00:05:21,090 --> 00:05:22,422 Much better. 125 00:05:22,524 --> 00:05:24,825 Dr. Murphy, do you really want people knowing the details 126 00:05:24,927 --> 00:05:26,026 of your personal life? 127 00:05:26,128 --> 00:05:29,564 You don't think they took it as an abstract question? 128 00:05:29,666 --> 00:05:32,600 No. We all take it as something that happened between you and Lea. 129 00:05:32,702 --> 00:05:33,801 And that there was a fight. 130 00:05:33,903 --> 00:05:35,336 Sometime before 8:00 a.m. today, 131 00:05:35,438 --> 00:05:37,571 which was when the poll was sent out. 132 00:05:39,108 --> 00:05:40,741 You are very astute. 133 00:05:40,843 --> 00:05:43,978 I'm seeing diffuse dilation of the large bowel here. 134 00:05:44,080 --> 00:05:46,346 Is that normal? 135 00:05:46,448 --> 00:05:49,750 Some calcified lesions. 136 00:05:49,852 --> 00:05:51,251 Wall's thin, too. 137 00:05:51,353 --> 00:05:52,419 Hirschsprung's. 138 00:05:52,521 --> 00:05:54,354 I thought Hirschsprung's was a disease only babies 139 00:05:54,457 --> 00:05:55,455 and young children got. 140 00:05:55,557 --> 00:05:57,391 It is. 141 00:05:57,493 --> 00:05:58,625 But he has it. 142 00:06:06,268 --> 00:06:07,869 We treated the Hirschsprung's 143 00:06:07,971 --> 00:06:09,337 by removing the dilated part of your colon. 144 00:06:09,440 --> 00:06:11,340 It won't impact your life, 145 00:06:11,442 --> 00:06:13,008 but we would like an explanation. 146 00:06:13,109 --> 00:06:14,376 Dr. Murphy doesn't mean 147 00:06:14,478 --> 00:06:16,011 we expect you to be a diagnostician. 148 00:06:16,112 --> 00:06:17,312 It's just... 149 00:06:17,414 --> 00:06:19,080 this was kind of singular. 150 00:06:19,182 --> 00:06:21,450 So, if you have any thoughts... 151 00:06:21,552 --> 00:06:24,820 Did anyone in your family suddenly develop these symptoms? 152 00:06:28,772 --> 00:06:32,641 I did something singular to myself about six months ago. 153 00:06:32,744 --> 00:06:35,410 I modified my genetic code. 154 00:06:35,513 --> 00:06:38,180 I did a CRISPR procedure under the guidance of some researchers 155 00:06:38,282 --> 00:06:39,581 I know in China through my work. 156 00:06:39,683 --> 00:06:41,350 They put together a series of cocktails. 157 00:06:41,452 --> 00:06:45,754 They FedExed them to be, and Sophie helped me inject them 158 00:06:45,856 --> 00:06:47,055 into my bone marrow. 159 00:06:47,158 --> 00:06:48,423 Why? 160 00:06:48,525 --> 00:06:49,824 If you know anything about CRISPR, 161 00:06:49,927 --> 00:06:51,927 you know how risky it is to tinker with your genome. 162 00:06:52,029 --> 00:06:55,097 You have no idea what problems you might let loose. 163 00:06:55,199 --> 00:06:57,299 I needed to optimize my telomerase activity. 164 00:06:57,401 --> 00:06:58,934 It's the enzyme responsible for correcting 165 00:06:59,036 --> 00:06:59,969 cell replication errors... 166 00:07:00,071 --> 00:07:01,136 essentially, the cause of aging. 167 00:07:01,238 --> 00:07:02,404 You can't stop aging 168 00:07:02,506 --> 00:07:04,506 through changing your telomerase activity. 169 00:07:04,608 --> 00:07:08,177 You might extend your life a little, but exercise... 170 00:07:08,279 --> 00:07:09,644 it does the same thing. 171 00:07:09,747 --> 00:07:10,645 Much less risky. 172 00:07:10,747 --> 00:07:12,248 Your decision makes no sense. 173 00:07:12,350 --> 00:07:15,884 Extending my life by a few years is only my short-term goal. 174 00:07:15,987 --> 00:07:17,953 Look, you know how fast medicine is moving. 175 00:07:18,055 --> 00:07:19,854 The day isn't that far away when cloning 176 00:07:19,957 --> 00:07:22,891 will make transplants as easy as switching out a light socket. 177 00:07:22,993 --> 00:07:24,693 AI will start to make breakthroughs 178 00:07:24,795 --> 00:07:26,361 that we can't predict or understand. 179 00:07:26,463 --> 00:07:29,531 Medical knowledge will rise exponentially. 180 00:07:29,633 --> 00:07:32,133 There are babies born now who could live to see it, 181 00:07:32,236 --> 00:07:34,169 could live to be 1,000 years old. 182 00:07:34,271 --> 00:07:35,805 Maybe more. Maybe forever. 183 00:07:35,907 --> 00:07:38,440 Or at least, as long as they want to. 184 00:07:38,542 --> 00:07:40,875 So, our plan is to give my CRISPR a year 185 00:07:40,978 --> 00:07:42,944 to make sure the telomerase change works, 186 00:07:43,047 --> 00:07:45,414 and then we'll do her. 187 00:07:47,150 --> 00:07:49,385 We'll aspirate a sample of your bone marrow. 188 00:07:49,487 --> 00:07:51,253 See if we can figure out what the hell you did. 189 00:07:58,895 --> 00:07:59,929 Hey. 190 00:08:00,031 --> 00:08:04,233 Um... I don't think coffee's a good idea. 191 00:08:04,335 --> 00:08:06,068 Entire civilizations rely on it. 192 00:08:06,170 --> 00:08:08,169 But I don't think you're referring to the beverage itself. 193 00:08:08,272 --> 00:08:10,005 I don't think it's a good idea for first-years 194 00:08:10,107 --> 00:08:11,340 and fourth-years to go out. 195 00:08:11,442 --> 00:08:14,309 I am bound to supervise you at some point in the future, 196 00:08:14,411 --> 00:08:17,512 and it'd get complicated trying to change dates out, 197 00:08:17,615 --> 00:08:20,449 and the fact is... 198 00:08:20,551 --> 00:08:23,418 seeing somebody you work with rarely ends happily. 199 00:08:23,520 --> 00:08:25,487 So, I appreciate you thinking of me, but I... 200 00:08:25,589 --> 00:08:28,723 Oh, you thought it was a date. 201 00:08:28,825 --> 00:08:30,492 I'm still new here, and I thought it was 202 00:08:30,594 --> 00:08:33,795 a good opportunity to get to know each other. 203 00:08:33,897 --> 00:08:35,998 Coffee's perfect because you're asking 204 00:08:36,100 --> 00:08:38,767 the least amount of commitment from another human being. 205 00:08:38,870 --> 00:08:40,835 It's not even lunch. 206 00:08:40,937 --> 00:08:42,871 If it's still a "no," it's still a "no," 207 00:08:42,973 --> 00:08:45,407 but I'll let you re-think your answer. 208 00:08:48,269 --> 00:08:52,146 _ 209 00:08:53,389 --> 00:08:54,994 _ 210 00:08:55,094 --> 00:08:58,430 _ 211 00:08:58,830 --> 00:09:01,223 He only claimed it wasn't a date to save face. 212 00:09:01,292 --> 00:09:03,658 Or maybe I just assumed. 213 00:09:03,760 --> 00:09:04,926 But why did I assume? 214 00:09:05,028 --> 00:09:06,761 I don't think I'm some kind of narcissist 215 00:09:06,830 --> 00:09:09,898 who thinks every man wants to get close to me. 216 00:09:10,565 --> 00:09:13,933 Or we both assumed it's a date because it's a date. 217 00:09:14,002 --> 00:09:16,035 This is fun. I like being your bestie. 218 00:09:16,137 --> 00:09:17,369 Slumber party? 219 00:09:23,749 --> 00:09:26,550 I made a poll to test the popularity of shower sex. 220 00:09:26,652 --> 00:09:27,684 I heard. 221 00:09:27,753 --> 00:09:29,720 I fielded some questions about that. 222 00:09:29,788 --> 00:09:34,057 "Approve" has won, but don't get too excited, Lea. 223 00:09:34,160 --> 00:09:36,426 It's only 58-38, 224 00:09:36,494 --> 00:09:38,929 with several complicated noncommittals, 225 00:09:38,997 --> 00:09:41,197 so clearly my attitude is reasonable. 226 00:09:41,266 --> 00:09:43,400 We don't have room for a... 227 00:09:43,469 --> 00:09:45,501 skier exercise thing. 228 00:09:45,571 --> 00:09:48,404 I'm only putting it together so I can take a picture 229 00:09:48,473 --> 00:09:49,706 and sell it online. 230 00:09:50,702 --> 00:09:52,902 Why do you have it if you don't want it? 231 00:09:58,510 --> 00:10:02,078 My ex sent it. 232 00:10:02,180 --> 00:10:03,813 "Ex"? 233 00:10:03,915 --> 00:10:06,649 Husband. 234 00:10:07,267 --> 00:10:09,034 I left this thing in the attic 235 00:10:09,102 --> 00:10:11,202 until I got settled somewhere with enough space. 236 00:10:11,271 --> 00:10:12,937 And okay, that was 10 years ago, 237 00:10:13,006 --> 00:10:14,539 but it's not like it was in his way. 238 00:10:18,211 --> 00:10:22,313 We got married, not for long, right out of high school. 239 00:10:22,382 --> 00:10:23,948 Literally the boy next door. 240 00:10:24,017 --> 00:10:25,983 We grew up together. People expected it. 241 00:10:26,052 --> 00:10:29,087 It... was a big mistake. 242 00:10:29,155 --> 00:10:31,740 We both realized it pretty quickly. 243 00:10:36,807 --> 00:10:38,806 Why would you even want to live forever? 244 00:10:38,875 --> 00:10:40,108 You'd be bored out of your mind. 245 00:10:41,278 --> 00:10:42,544 The person I am now 246 00:10:42,612 --> 00:10:47,115 is miles away from the person I was at 14. 247 00:10:47,217 --> 00:10:50,418 I only get more distant every year. 248 00:10:50,487 --> 00:10:54,589 You learn to understand, 249 00:10:54,658 --> 00:10:58,260 love books that you once hated, 250 00:10:58,328 --> 00:11:01,029 sometimes people you once hated. 251 00:11:01,098 --> 00:11:05,633 Music that you didn't get the point of becomes magical. 252 00:11:06,671 --> 00:11:08,836 And a thousand new doors will open. 253 00:11:08,936 --> 00:11:09,971 I look forward to the adventure. 254 00:11:12,186 --> 00:11:14,754 Sorry. Adventure's not always gonna be fun. 255 00:11:16,157 --> 00:11:19,525 I figure it takes 40 or 50 years 256 00:11:19,594 --> 00:11:21,961 just to get over the things your parents did. 257 00:11:22,029 --> 00:11:24,242 If only we lived long enough, 258 00:11:24,342 --> 00:11:28,083 the human race might finally have a chance to grow up. 259 00:11:34,917 --> 00:11:37,385 What size shoes do you wear? 260 00:11:37,453 --> 00:11:39,887 71/2. 261 00:11:39,989 --> 00:11:41,989 "Dr. Allen's Walking On Clouds Inserts." 262 00:11:42,058 --> 00:11:44,358 Putting "doctor" in the name is always good marketing strategy. 263 00:11:44,427 --> 00:11:46,960 They're designed to reduce inflammation 264 00:11:47,029 --> 00:11:49,030 that could lead to plantar fasciitis, 265 00:11:49,132 --> 00:11:51,832 calluses, arthritis, and they feel damn good. 266 00:11:51,901 --> 00:11:53,634 Does this have anything to do with our patient's 267 00:11:53,703 --> 00:11:54,835 venture capitalist husband? 268 00:11:54,904 --> 00:11:56,337 I need testimonials. 269 00:11:56,405 --> 00:11:57,838 Labs and Path for Hannah Palmer. 270 00:12:01,077 --> 00:12:03,877 Aren't we all busy enough learning how to be surgeons? 271 00:12:03,913 --> 00:12:06,447 Do you really want to divide your focus onto something trivial? 272 00:12:12,340 --> 00:12:15,475 Because wanting to make money taints the purity of medicine? 273 00:12:17,312 --> 00:12:18,845 I have five brothers. 274 00:12:18,880 --> 00:12:21,147 I've been taking care of people my whole life. 275 00:12:21,215 --> 00:12:24,584 Someone got hurt, they came to me to patch them up. 276 00:12:24,652 --> 00:12:27,787 I became a doctor so I could get paid for it, 277 00:12:27,856 --> 00:12:30,890 but also because I'm good at taking care of people. 278 00:12:30,925 --> 00:12:33,125 It's possible to do something for more than one reason. 279 00:12:44,439 --> 00:12:46,460 The news is bad. 280 00:12:55,651 --> 00:12:58,819 There's an abnormally healthy population 281 00:12:58,887 --> 00:13:01,788 of hematopoietic progenitor stem cells. 282 00:13:01,857 --> 00:13:02,889 He did it? 283 00:13:02,958 --> 00:13:04,090 It's significant. 284 00:13:04,159 --> 00:13:07,026 He's succeeded in optimizing enough telomerase activity 285 00:13:07,095 --> 00:13:10,138 to potentially add 10 years to his natural life. 286 00:13:10,191 --> 00:13:12,528 Well, assuming it doesn't subtract about 50. 287 00:13:12,561 --> 00:13:14,184 There's already an autoimmune reaction 288 00:13:14,284 --> 00:13:15,427 that mimics Hirschsprung's. 289 00:13:15,571 --> 00:13:15,979 Who knows what else he did? 290 00:13:16,048 --> 00:13:18,516 What if this is the opposite of an auto-immune condition? 291 00:13:18,584 --> 00:13:19,550 What if he's done something 292 00:13:19,619 --> 00:13:22,109 that lowers his resistance to infection? 293 00:13:22,194 --> 00:13:24,742 Then we'd be seeing more opportunistic infections 294 00:13:24,792 --> 00:13:25,638 of the lungs and skin. 295 00:13:26,155 --> 00:13:27,888 If you lived another 1,000 years, 296 00:13:27,988 --> 00:13:30,206 would you be with the same person at the end 297 00:13:30,275 --> 00:13:31,394 as at the beginning? 298 00:13:31,858 --> 00:13:31,962 - No. - No. 299 00:13:34,080 --> 00:13:35,546 No, if you assume monogamy. 300 00:13:35,615 --> 00:13:37,481 I mean, that puts too much strain on a relationship. 301 00:13:37,551 --> 00:13:39,451 Is one person supposed to be everything to another, 302 00:13:39,519 --> 00:13:41,218 all the time, for 1,000 years? 303 00:13:41,320 --> 00:13:44,989 Apparently Jesus agrees. On monogamy. 304 00:13:45,058 --> 00:13:47,191 He said that, in Heaven, there'll be no more marriages. 305 00:13:47,260 --> 00:13:50,494 I guess humans can't sustain a relationship that long. 306 00:13:50,596 --> 00:13:51,863 You read the New Testament, too? 307 00:13:51,932 --> 00:13:54,499 And the Qur'an. And other things. 308 00:13:54,568 --> 00:13:55,667 It's like you're a stalker. 309 00:13:55,735 --> 00:13:58,135 It's like you and God had an acrimonious divorce. 310 00:13:58,204 --> 00:14:01,673 What if he caused neurofibromatosis? 311 00:14:01,741 --> 00:14:03,842 Microscopic tumors forming on the nerve sheath? 312 00:14:04,802 --> 00:14:06,200 Possible, but there'd have been 313 00:14:06,269 --> 00:14:07,502 some evidence of Schwann cell growth 314 00:14:07,605 --> 00:14:08,737 around his colon. 315 00:14:08,806 --> 00:14:11,506 Would you still love your wife in 1,000 years? 316 00:14:13,277 --> 00:14:15,243 You have three answers. That should be enough. 317 00:14:15,311 --> 00:14:17,512 Park's marriage failed in far less time, 318 00:14:17,581 --> 00:14:19,047 and Enrique doesn't even try. 319 00:14:19,149 --> 00:14:20,649 Asher is an... 320 00:14:20,717 --> 00:14:22,050 unknown quantity. 321 00:14:22,152 --> 00:14:23,618 You're committed. 322 00:14:23,687 --> 00:14:25,020 You've made promises. 323 00:14:27,390 --> 00:14:29,324 I've made promises based on 324 00:14:29,392 --> 00:14:32,994 an understood human life-span, Murphy. 325 00:14:33,766 --> 00:14:36,700 Most likely diagnosis is autoimmune polyneuropathy. 326 00:14:36,802 --> 00:14:38,369 It damaged the enteral ganglion nerve 327 00:14:38,438 --> 00:14:39,737 and led to the perforations. 328 00:14:39,805 --> 00:14:42,439 Start him on steroids and immunosuppressants. 329 00:14:42,542 --> 00:14:43,807 Dr. Andrews. 330 00:14:43,909 --> 00:14:45,676 So, you wouldn't have gotten married 331 00:14:45,778 --> 00:14:47,445 if you thought it would be forever. 332 00:14:47,513 --> 00:14:50,147 You expect all relationships to fail over time. 333 00:14:50,216 --> 00:14:51,948 It's just a question of how long? 334 00:14:53,786 --> 00:14:55,853 I love her now. 335 00:14:55,921 --> 00:15:00,157 I intend to love her as long as I live. 336 00:15:00,226 --> 00:15:04,795 But, eventually, everything breaks. 337 00:15:14,299 --> 00:15:15,499 I always go back to comfort reading 338 00:15:15,600 --> 00:15:16,766 when I'm in the hospital. 339 00:15:16,835 --> 00:15:18,635 Cozy mysteries in little English villages, 340 00:15:18,703 --> 00:15:21,004 where nothing bad happens to anyone we like. 341 00:15:22,774 --> 00:15:24,607 We've gotten your results back. 342 00:15:24,676 --> 00:15:25,642 When will your husband be... 343 00:15:25,711 --> 00:15:26,910 Is it cancer? 344 00:15:29,314 --> 00:15:30,447 Yes. 345 00:15:32,551 --> 00:15:34,951 Thyroid carcinoma. 346 00:15:35,019 --> 00:15:36,819 We're gonna do a complete imaging series 347 00:15:36,888 --> 00:15:37,987 to pinpoint just how advanced... 348 00:15:38,056 --> 00:15:39,989 Treatment? 349 00:15:40,538 --> 00:15:43,740 Surgery to remove some or all of your thyroid 350 00:15:43,842 --> 00:15:46,108 is usually the first line of defense. 351 00:15:46,210 --> 00:15:48,678 Sometimes, we can wait, but given the hematoma 352 00:15:48,780 --> 00:15:52,815 was probably caused by the tumor invading nearby vasculatures, 353 00:15:52,884 --> 00:15:55,217 we should probably do it in the next few days. 354 00:15:55,319 --> 00:15:58,487 Later, there'll be radioactive iodine treatment... 355 00:16:00,258 --> 00:16:01,524 Panic attack? 356 00:16:07,398 --> 00:16:08,631 Her trachea's deviated to the right. 357 00:16:08,733 --> 00:16:11,067 The tumor's compressing it. We're doing surgery now. 358 00:16:22,654 --> 00:16:24,087 What happened? The nurse just said "surgery." 359 00:16:24,189 --> 00:16:26,590 Was it the hematoma? 360 00:16:26,658 --> 00:16:28,025 It's more serious. 361 00:16:29,761 --> 00:16:32,095 I-It's not cancer... 362 00:16:32,197 --> 00:16:33,730 again. 363 00:16:33,799 --> 00:16:36,433 Thyroid carcinoma. 364 00:16:36,501 --> 00:16:39,268 We've removed her thyroid. She's doing well. 365 00:16:39,338 --> 00:16:41,004 We're looking into potential causes... 366 00:16:41,072 --> 00:16:42,772 genetic, environmental. 367 00:16:42,841 --> 00:16:47,293 There may be a deeper issue that we can find and address. 368 00:16:57,820 --> 00:17:01,288 I can't do this. 369 00:17:01,390 --> 00:17:03,924 You've done it before. 370 00:17:04,026 --> 00:17:06,259 You'll do it this time. 371 00:17:11,200 --> 00:17:13,667 Do you know what it's like... 372 00:17:13,736 --> 00:17:15,235 to wake up every morning and know your wife 373 00:17:15,304 --> 00:17:16,803 might not be here next year? 374 00:17:19,890 --> 00:17:22,858 All those treatments... 375 00:17:22,926 --> 00:17:26,194 they all... they all have this little tag attached to them 376 00:17:26,296 --> 00:17:29,530 that says, "Because she might die." 377 00:17:29,599 --> 00:17:33,001 And you see them put those gloves on 378 00:17:33,103 --> 00:17:34,202 before they hook up the chemo. 379 00:17:34,271 --> 00:17:36,971 You know why they do that. 380 00:17:37,040 --> 00:17:38,840 It's because it's poison. 381 00:17:41,044 --> 00:17:43,712 And you sit there... 382 00:17:43,780 --> 00:17:47,415 and you watch them shove poison into the person you love. 383 00:17:47,517 --> 00:17:50,351 And why? 384 00:17:50,420 --> 00:17:52,587 Because she might die. 385 00:17:54,858 --> 00:17:57,492 We're killing her because she might die. 386 00:18:03,223 --> 00:18:04,422 Go for a run. 387 00:18:04,491 --> 00:18:07,091 Go punch a wall. 388 00:18:07,160 --> 00:18:08,826 You need to release some endorphins. 389 00:18:08,895 --> 00:18:10,595 My release is my job. 390 00:18:10,697 --> 00:18:12,296 That's why I love it. 391 00:18:12,398 --> 00:18:15,066 My work requires total focus. 392 00:18:15,168 --> 00:18:16,334 And every minute I'm working 393 00:18:16,402 --> 00:18:19,103 is a minute I'm not thinking about... 394 00:18:19,205 --> 00:18:20,304 losing her. 395 00:18:26,145 --> 00:18:27,575 I have to go. 396 00:18:33,801 --> 00:18:36,869 Your pain and weakness are consistent with polyneuropathy, 397 00:18:36,937 --> 00:18:39,404 treatable with steroids and immunosuppressants. 398 00:18:39,473 --> 00:18:42,574 If you live 1,000 years, will you still love Sophie? 399 00:18:45,012 --> 00:18:46,044 Yes. 400 00:18:46,147 --> 00:18:47,846 How can you be sure? 401 00:18:47,915 --> 00:18:50,415 People change. You expect to change. 402 00:18:50,484 --> 00:18:53,652 Sophie and I will change together. 403 00:18:53,721 --> 00:18:55,497 We'll go through the same adventures 404 00:18:55,570 --> 00:18:56,575 and learn the same lessons. 405 00:18:56,775 --> 00:18:58,423 What if you go through the same adventures 406 00:18:58,492 --> 00:18:59,925 and learn different lessons? 407 00:19:00,819 --> 00:19:03,720 Even if we did, whoever, whatever we become, 408 00:19:03,789 --> 00:19:05,387 Sophie will always be beautiful. 409 00:19:05,456 --> 00:19:08,024 I mean, she could turn into a machine or a set of pixels 410 00:19:08,093 --> 00:19:10,860 or a giant purple flower, and she'll still be beautiful, 411 00:19:10,962 --> 00:19:13,830 because it's part of her essential nature. 412 00:19:16,968 --> 00:19:19,268 But if you don't know how you'll change, 413 00:19:19,337 --> 00:19:21,003 you don't know how you'll change. 414 00:19:21,105 --> 00:19:23,472 Shaun. 415 00:19:23,574 --> 00:19:24,841 We'll let you get some rest. 416 00:19:24,943 --> 00:19:27,076 The steroids should make you feel a lot better. 417 00:19:33,901 --> 00:19:39,004 Why didn't you ever mention you had an ex-husband? 418 00:19:39,073 --> 00:19:42,941 Shaun, I've barely thought about him in years. 419 00:19:43,010 --> 00:19:46,812 I didn't mention him because he's not important. 420 00:19:46,881 --> 00:19:49,748 I know. That's the problem. 421 00:19:49,817 --> 00:19:52,718 At one time, you felt he was important enough to your life 422 00:19:52,787 --> 00:19:56,321 to marry him, and now you barely think of him. 423 00:19:56,390 --> 00:19:59,892 You make long-term plans, you have expectations, 424 00:19:59,960 --> 00:20:01,594 and then something happens to you, 425 00:20:01,662 --> 00:20:05,898 and suddenly you're a different person. 426 00:20:06,684 --> 00:20:11,588 I know you don't like change, but it's not all bad. 427 00:20:11,656 --> 00:20:15,892 After all, you are working to change yourself all the time. 428 00:20:15,960 --> 00:20:21,864 I'm working to be a better surgeon, a better boyfriend, 429 00:20:21,966 --> 00:20:24,333 better at the things I've chosen, 430 00:20:24,436 --> 00:20:28,142 but this... other change... it's unpredictable. 431 00:20:28,228 --> 00:20:29,163 You don't choose it. 432 00:20:29,237 --> 00:20:30,476 It just comes at you. 433 00:20:31,218 --> 00:20:33,785 Oh, it's like hurricanes before 1873, 434 00:20:33,887 --> 00:20:35,821 when the Army Signal Corps first put up flags 435 00:20:35,890 --> 00:20:37,389 to warn people storms were coming. 436 00:20:37,458 --> 00:20:39,992 Before that, houses were flattened, lives destroyed, 437 00:20:40,094 --> 00:20:42,394 and there was no way to see it was heading for you. 438 00:20:42,496 --> 00:20:44,463 Shaun. 439 00:20:44,532 --> 00:20:48,134 Our relationship will not end in natural disaster. 440 00:20:48,202 --> 00:20:49,634 It did begin in one. 441 00:20:52,006 --> 00:20:54,974 I'm going to look in on my patient. 442 00:20:55,042 --> 00:20:56,909 Okay. 443 00:21:04,415 --> 00:21:07,817 Blood and saliva will tell us if there's a genetic cause, 444 00:21:07,886 --> 00:21:09,585 and the samples we take from your house 445 00:21:09,655 --> 00:21:11,620 will tell us if there's something environmental. 446 00:21:13,491 --> 00:21:16,826 I know it's s-stupid. 447 00:21:16,928 --> 00:21:19,362 I've almost felt guilty for my cancer, 448 00:21:19,430 --> 00:21:23,699 like I arbitrarily decided to be sick and burdensome. 449 00:21:26,104 --> 00:21:27,503 Do the people you're close to 450 00:21:27,572 --> 00:21:30,239 ever act like you're a burden to them? 451 00:21:31,272 --> 00:21:32,405 You mean Alan. 452 00:21:34,643 --> 00:21:36,442 He's scared. 453 00:21:36,511 --> 00:21:40,647 He takes the exit he's got and he turns to his work. 454 00:21:40,716 --> 00:21:42,415 You're okay with that? 455 00:21:49,791 --> 00:21:52,125 I accept this compromise. 456 00:21:52,193 --> 00:21:53,159 That's not the hard part. 457 00:21:53,228 --> 00:21:55,194 The hard part is... 458 00:21:55,296 --> 00:21:58,297 not knowing. 459 00:21:58,366 --> 00:22:02,836 Each new thing that happens, I worry, "Is this it? 460 00:22:02,938 --> 00:22:06,005 Is this where I lose him? 461 00:22:06,074 --> 00:22:07,841 Is this where he breaks?" 462 00:22:15,966 --> 00:22:18,401 So, this is boiled coffee. 463 00:22:18,469 --> 00:22:20,102 Some people call it "Turkish coffee," 464 00:22:20,204 --> 00:22:23,071 or "Greek coffee," or "Egyptian coffee"... 465 00:22:23,140 --> 00:22:24,340 because we need to take ownership 466 00:22:24,409 --> 00:22:25,874 and put things in categories. 467 00:22:25,976 --> 00:22:27,576 Yeah. 468 00:22:27,678 --> 00:22:29,111 You actually live in this thing, 469 00:22:29,179 --> 00:22:31,280 in the hospital parking garage? 470 00:22:31,382 --> 00:22:32,448 Why not? 471 00:22:32,550 --> 00:22:33,715 Convenient for work. 472 00:22:33,784 --> 00:22:36,118 When I want to spend a few days off the beaten track, 473 00:22:36,187 --> 00:22:38,320 it's convenient for that, too. 474 00:22:38,389 --> 00:22:41,022 I'm gonna get three sips in this. 475 00:22:41,091 --> 00:22:43,058 But three really great sips. 476 00:22:44,729 --> 00:22:46,562 That's how I try to live my life... 477 00:22:46,664 --> 00:22:50,799 try to appreciate, savor, not pass by. 478 00:22:54,389 --> 00:22:57,457 Is that what the polyamory is about? 479 00:22:57,526 --> 00:23:00,193 Does it really work, or is it one of those theories about life 480 00:23:00,295 --> 00:23:02,028 that people regret later? 481 00:23:02,097 --> 00:23:03,196 No regrets so far. 482 00:23:03,265 --> 00:23:04,765 No, I guess not. 483 00:23:04,833 --> 00:23:08,034 Not while you're young and having fun. 484 00:23:08,103 --> 00:23:09,336 It is fun, 485 00:23:09,438 --> 00:23:11,104 but not for the reasons that you're thinking. 486 00:23:11,206 --> 00:23:13,339 It isn't about sex. 487 00:23:13,441 --> 00:23:16,242 It's about commitment, emotional connection. 488 00:23:16,311 --> 00:23:18,545 The joy I'm sure you get out of a relationship, 489 00:23:18,647 --> 00:23:19,546 I get a little more. 490 00:23:19,648 --> 00:23:21,648 Also, I have to give a little more. 491 00:23:21,717 --> 00:23:24,217 But that's meaningful, too. 492 00:23:26,888 --> 00:23:28,488 Do you mind if I ask you something, 493 00:23:28,557 --> 00:23:30,256 since we're getting personal? 494 00:23:34,853 --> 00:23:36,218 Sure. 495 00:23:36,320 --> 00:23:38,721 What's your favorite misheard song lyric? 496 00:23:47,131 --> 00:23:48,531 This is nice. 497 00:23:50,535 --> 00:23:52,969 I'm glad it's not a date. 498 00:23:53,071 --> 00:23:54,503 Me, too. 499 00:23:54,605 --> 00:23:56,372 I don't believe in those categories. 500 00:24:00,879 --> 00:24:03,345 He reported widespread bilateral pain, 501 00:24:03,447 --> 00:24:04,347 then he keeled over. 502 00:24:04,449 --> 00:24:05,715 B.P. dropped to 80 over palp. 503 00:24:05,817 --> 00:24:06,849 I'll order a vasopressor. 504 00:24:06,951 --> 00:24:08,284 - Already did. - Good. 505 00:24:08,386 --> 00:24:12,221 We need an EKG, CBC, and chest images, and a new diagnosis. 506 00:24:12,323 --> 00:24:15,024 Whatever he caused with CRISPR, it's not just neuropathy. 507 00:24:15,126 --> 00:24:16,993 Something else is killing him. 508 00:24:23,447 --> 00:24:25,247 What if he's caused something that mimics 509 00:24:25,347 --> 00:24:26,871 carcinomatous autonomic neuropathy? 510 00:24:27,411 --> 00:24:29,444 It explains the B.P. and bowel issue. 511 00:24:29,948 --> 00:24:32,693 That doesn't explain the sensory issue that led to the frostbite. 512 00:24:36,076 --> 00:24:37,575 A connective tissue disorder? 513 00:24:37,644 --> 00:24:38,910 That would have shown up on the scans. 514 00:24:39,012 --> 00:24:40,012 His chest looks normal. 515 00:24:45,930 --> 00:24:47,130 Maybe we can't think of the answer 516 00:24:47,198 --> 00:24:48,397 because there is no answer. 517 00:24:48,466 --> 00:24:50,432 We keep trying to jam it into these categories we know, 518 00:24:50,501 --> 00:24:51,500 the diseases that we know. 519 00:24:51,602 --> 00:24:54,170 But this never existed before. 520 00:24:54,239 --> 00:24:56,072 He created a new combination of genetic code. 521 00:24:56,141 --> 00:24:57,873 That means a new combination of symptoms. 522 00:24:57,908 --> 00:25:00,042 So, we shouldn't be looking at what fits the picture, 523 00:25:00,111 --> 00:25:01,678 but at what's closest to the picture, 524 00:25:01,746 --> 00:25:03,479 so we can at least figure out a treatment. 525 00:25:03,547 --> 00:25:07,216 And what it's closest to is amyloidosis. 526 00:25:07,791 --> 00:25:10,224 This isn't an autoimmune neuropathy, 527 00:25:10,260 --> 00:25:12,527 so the nerves must be under attack by something else. 528 00:25:12,596 --> 00:25:14,563 Something like amyloid disease could leave deposits 529 00:25:14,631 --> 00:25:17,232 along the nerves, causing the symptoms we've seen. 530 00:25:17,301 --> 00:25:19,066 Where do we look for those deposits? 531 00:25:19,168 --> 00:25:21,035 The spleen. 532 00:25:28,097 --> 00:25:29,529 Drink all 8 ounces. 533 00:25:29,632 --> 00:25:32,532 We talked. We had a few laughs. 534 00:25:32,635 --> 00:25:34,334 Well, sounds date-y to me. 535 00:25:35,437 --> 00:25:37,104 I don't think Enrique's a player. 536 00:25:37,173 --> 00:25:38,572 No, he's kind of the opposite of a player. 537 00:25:38,641 --> 00:25:41,041 With him, emotional connection is the point. 538 00:25:41,110 --> 00:25:43,143 He's trying to live some idealistic fantasy 539 00:25:43,212 --> 00:25:45,045 where everyone is nice and no one is jealous. 540 00:25:45,114 --> 00:25:46,547 I am so staying away. 541 00:25:46,649 --> 00:25:47,748 Well, of course. 542 00:25:47,817 --> 00:25:48,916 Once I heard "emotional connection," 543 00:25:49,018 --> 00:25:50,651 I knew the game was over. 544 00:25:50,720 --> 00:25:51,985 What does that mean? 545 00:25:52,087 --> 00:25:53,721 I'm against emotion? 546 00:25:53,756 --> 00:25:55,790 I'm not the one with "cold-hearted bitch" 547 00:25:55,892 --> 00:25:57,458 as my social media hashtag. 548 00:25:57,527 --> 00:25:58,626 She's an excellent doctor. 549 00:25:58,728 --> 00:26:00,060 Every time you've loved somebody, 550 00:26:00,129 --> 00:26:01,996 it's ended in disappointment or death... 551 00:26:02,097 --> 00:26:03,063 sometimes both. 552 00:26:03,806 --> 00:26:05,038 It's like a reflex now. 553 00:26:05,108 --> 00:26:08,041 You just expect that everything ends badly, so why start? 554 00:26:08,111 --> 00:26:11,378 So, despite the many practical reasons not to go out 555 00:26:11,447 --> 00:26:13,347 with a first-year, this is all about me? 556 00:26:13,416 --> 00:26:16,850 Is that a diamond ring? 557 00:26:16,919 --> 00:26:18,018 I mean, it's pretty. 558 00:26:18,120 --> 00:26:19,620 Our patient caught her fianc� cheating. 559 00:26:19,688 --> 00:26:21,622 Big fight. He demanded the ring back. 560 00:26:21,724 --> 00:26:22,990 She swallowed it. 561 00:26:23,058 --> 00:26:24,157 I did. 562 00:26:24,226 --> 00:26:25,393 You don't even know if this is "going out," 563 00:26:25,461 --> 00:26:26,694 and that's the point. 564 00:26:27,338 --> 00:26:29,172 It doesn't matter what Enrique's offering. 565 00:26:29,240 --> 00:26:31,475 Whether it's friendship or romance, you're not investing. 566 00:26:31,577 --> 00:26:32,676 You're risk-averse. 567 00:26:32,778 --> 00:26:33,809 Your portfolio right now 568 00:26:33,879 --> 00:26:35,812 is entirely in T-Bills and money market. 569 00:26:35,881 --> 00:26:37,046 I have no idea what that means. 570 00:26:37,115 --> 00:26:38,715 And it's too bad, because a guy that can make you laugh 571 00:26:38,784 --> 00:26:40,617 might be just what you need right now. 572 00:26:41,630 --> 00:26:43,426 It's progressed to your large intestine. 573 00:26:43,589 --> 00:26:45,856 Here's a plastic bag. Put it over the toilet seat. 574 00:26:45,925 --> 00:26:47,992 You'll have every opportunity to recover your property. 575 00:26:52,064 --> 00:26:55,098 Don't run away from a chance at love. 576 00:26:55,167 --> 00:26:58,235 It's a date... 577 00:26:58,337 --> 00:26:59,237 maybe. 578 00:26:59,339 --> 00:27:00,238 I don't know. 579 00:27:03,609 --> 00:27:05,442 Her house is full of T.C.E.... 580 00:27:05,511 --> 00:27:06,643 a side effect from chip-making 581 00:27:06,712 --> 00:27:08,512 back in Silicon Valley's early days. 582 00:27:08,615 --> 00:27:10,447 So, they move away from their toxic home, 583 00:27:10,516 --> 00:27:11,882 and hopefully things get a little better. 584 00:27:11,985 --> 00:27:13,184 Probably not much. 585 00:27:13,252 --> 00:27:15,119 She also has a genetic predisposition. 586 00:27:15,221 --> 00:27:16,920 It's both? 587 00:27:16,989 --> 00:27:18,755 She shouldn't go outside in a rainstorm. 588 00:27:20,259 --> 00:27:21,926 How do you tell a woman that her third cancer 589 00:27:22,028 --> 00:27:23,761 likely won't be close to her last? 590 00:27:26,799 --> 00:27:29,266 Unfortunately, this is a teaching moment. 591 00:27:32,607 --> 00:27:35,074 Dr. Allen, after 12 hours on duty, 592 00:27:35,143 --> 00:27:37,744 I can report that your inserts came through. 593 00:27:37,846 --> 00:27:40,079 Check your e-mail. You'll find my testimonial. 594 00:27:41,182 --> 00:27:42,115 Claire. Olivia. 595 00:27:49,658 --> 00:27:52,759 And if you're right, what will you do? 596 00:27:52,828 --> 00:27:55,294 We'll treat the symptoms with targeted drug therapies. 597 00:27:55,363 --> 00:27:57,897 There really isn't a disease, as such, that we can address. 598 00:28:05,932 --> 00:28:06,865 The pain shifted? 599 00:28:06,967 --> 00:28:07,966 Yeah. 600 00:28:09,269 --> 00:28:10,436 Never mind about the ultrasound. 601 00:28:10,538 --> 00:28:11,803 It'll be easier to check for deposits 602 00:28:11,905 --> 00:28:12,871 after the organ's been removed. 603 00:28:12,973 --> 00:28:14,205 - After it's... - Yeah. 604 00:28:14,308 --> 00:28:16,141 His spleen's about to rupture. Call a transport team. 605 00:28:27,607 --> 00:28:30,656 It's called Li-Fraumeni Syndrome... LFS. 606 00:28:30,876 --> 00:28:32,242 An inherited predisposition 607 00:28:32,414 --> 00:28:33,904 to developing a wide range of cancers. 608 00:28:35,060 --> 00:28:36,860 Yes, there was a toxin in your environment 609 00:28:36,962 --> 00:28:38,495 that likely played a role in this, 610 00:28:38,564 --> 00:28:40,630 but there will be other triggers in the future. 611 00:28:40,699 --> 00:28:42,766 Your body is super sensitive 612 00:28:42,801 --> 00:28:45,368 and will respond with tumors for the rest of your life. 613 00:28:53,422 --> 00:28:56,023 I know that's a shock, 614 00:28:56,091 --> 00:28:58,425 but here's what you should know... 615 00:28:58,527 --> 00:29:02,062 most cancers are treatable if found early enough. 616 00:29:05,200 --> 00:29:07,968 We know the most common associated with LFS, 617 00:29:08,070 --> 00:29:10,103 and we can do surveillance... 618 00:29:10,171 --> 00:29:14,941 nip anything in the bud before it becomes a problem. 619 00:29:15,010 --> 00:29:19,045 It may not seem this way now, but this is good. 620 00:29:19,147 --> 00:29:21,014 We know what we're dealing with. 621 00:29:21,082 --> 00:29:23,950 We're warned, and we'll be ready. 622 00:29:32,941 --> 00:29:35,041 He won't be able to handle this. 623 00:29:39,615 --> 00:29:42,449 Liver, pancreas... other organs look normal. 624 00:29:43,819 --> 00:29:46,753 But there are calcified lesions along these nerves. 625 00:29:46,822 --> 00:29:48,755 He's gonna be in pain like this for the rest of his life. 626 00:29:48,857 --> 00:29:49,956 No. 627 00:29:50,025 --> 00:29:51,958 There's a reasonable chance it'll get worse 628 00:29:52,060 --> 00:29:53,326 as time goes on. 629 00:29:53,394 --> 00:29:55,328 I need my sharp-blunt curved scissors. 630 00:29:55,430 --> 00:29:57,697 What if we used CRISPR to reverse CRISPR? 631 00:30:00,051 --> 00:30:02,752 Researchers have identified a protein in certain bacteria 632 00:30:02,854 --> 00:30:04,688 that inhibits CRISPR. 633 00:30:04,756 --> 00:30:06,989 What if we insert the DNA that makes that protein 634 00:30:07,058 --> 00:30:08,291 into our patient's genome? 635 00:30:08,359 --> 00:30:10,126 That would deactivate the CRISPR gene. 636 00:30:10,228 --> 00:30:11,460 So, CRISPR messed him up permanently, 637 00:30:11,563 --> 00:30:13,162 and you think we should do more of it? 638 00:30:13,231 --> 00:30:14,898 I don't know. Our patient is a risk-taker. 639 00:30:14,966 --> 00:30:16,533 We'd need a delivery mechanism. 640 00:30:16,601 --> 00:30:18,768 The code would have to be introduced through a virus... 641 00:30:18,870 --> 00:30:21,804 a virus that specifically targets nerves. 642 00:30:24,068 --> 00:30:25,634 Polio targets nerves. 643 00:30:25,703 --> 00:30:27,536 Because this isn't risky enough. 644 00:30:27,605 --> 00:30:28,971 Polio is such a dangerous virus 645 00:30:29,040 --> 00:30:31,307 because it's so good at penetrating the nervous system. 646 00:30:35,152 --> 00:30:37,093 _ 647 00:30:38,516 --> 00:30:42,116 _ 648 00:30:43,420 --> 00:30:44,635 _ 649 00:30:44,714 --> 00:30:45,806 _ 650 00:30:49,717 --> 00:30:50,950 Dr. Murphy? 651 00:30:54,989 --> 00:30:59,826 She's going to be this way... forever. 652 00:30:59,894 --> 00:31:02,695 She'll have good periods and bad periods. 653 00:31:02,764 --> 00:31:06,299 But she will always have to be on her guard. 654 00:31:06,367 --> 00:31:10,174 Is she always gonna have to be on guard against you, too? 655 00:31:11,163 --> 00:31:12,296 What does that mean? 656 00:31:12,365 --> 00:31:14,531 Chronic illness puts strain on relationships. 657 00:31:14,599 --> 00:31:18,035 Statistically, it is more often the man who can't handle it. 658 00:31:18,103 --> 00:31:20,236 Our marriage is none of your business. 659 00:31:20,338 --> 00:31:22,005 Her health is my business. 660 00:31:22,074 --> 00:31:23,940 And your behavior adds to her stress. 661 00:31:26,111 --> 00:31:30,213 You look at her, and you imagine she's gone, and that is hard. 662 00:31:30,316 --> 00:31:31,515 I get it. 663 00:31:34,213 --> 00:31:37,714 She thinks the same thing when she looks at you. 664 00:31:37,783 --> 00:31:40,617 I never complain to her. I know it's nobody's fault. 665 00:31:40,686 --> 00:31:43,187 You don't think she knows you have trouble with all this? 666 00:31:43,255 --> 00:31:45,589 Every time something new happens, 667 00:31:45,657 --> 00:31:48,324 she wonders, is this the straw 668 00:31:48,394 --> 00:31:51,661 that is gonna break your marriage? 669 00:31:51,730 --> 00:31:54,197 You've got her living in a constant state of uncertainty. 670 00:31:54,266 --> 00:31:57,801 That is practically the definition of stress. 671 00:31:58,894 --> 00:32:02,895 So, this is the "straighten up and fly right" lecture. 672 00:32:02,998 --> 00:32:04,096 No. 673 00:32:06,001 --> 00:32:08,668 I am... 674 00:32:08,737 --> 00:32:13,640 I'm telling you to consider how best to time your divorce. 675 00:32:14,943 --> 00:32:17,744 There are gonna be a lot of new issues dropping on Hannah, 676 00:32:17,846 --> 00:32:19,612 and if you're gonna end up leaving anyway, 677 00:32:19,681 --> 00:32:20,913 you should start planning now. 678 00:32:21,016 --> 00:32:22,181 I don't want to leave my wife. 679 00:32:22,283 --> 00:32:24,784 My best advice? 680 00:32:24,853 --> 00:32:28,955 Help her through this next round of treatment as best you can, 681 00:32:29,058 --> 00:32:31,691 and then get out. 682 00:32:31,793 --> 00:32:35,128 It's hard living with someone who needs so much. 683 00:32:35,197 --> 00:32:39,032 I know you feel there is a point where you have nothing left, 684 00:32:39,134 --> 00:32:42,168 where you're ready to break. 685 00:32:42,271 --> 00:32:47,274 Just... don't break when she needs you most. 686 00:32:48,744 --> 00:32:50,743 Get out before that happens. 687 00:33:11,402 --> 00:33:13,503 Reading an article that's five years old? 688 00:33:13,571 --> 00:33:16,238 Dr. Glassman was once involved in an experimental attempt 689 00:33:16,307 --> 00:33:19,041 to treat Parkinson's with CRISPR technology. 690 00:33:19,143 --> 00:33:20,142 It failed. 691 00:33:20,177 --> 00:33:21,911 So, it's both old and it didn't work? 692 00:33:21,979 --> 00:33:24,479 Dr. Glassman likes his failures to be informative. 693 00:33:24,548 --> 00:33:26,415 That's why his articles are longer. 694 00:33:26,484 --> 00:33:29,284 Do you worry about losing the people you love? 695 00:33:35,473 --> 00:33:38,074 Because we can't stop ourselves from changing, 696 00:33:38,143 --> 00:33:40,310 which means we might stop loving someone, 697 00:33:40,412 --> 00:33:41,778 or they might stop loving us. 698 00:33:41,847 --> 00:33:44,113 It is a very bad thing. 699 00:33:44,215 --> 00:33:45,648 It is. 700 00:33:48,620 --> 00:33:52,721 So, no one can ever feel... safe. 701 00:33:52,757 --> 00:33:56,592 How can you keep going if you never feel safe? 702 00:34:01,942 --> 00:34:04,542 Well, sometimes, not changing is just as dangerous. 703 00:34:07,414 --> 00:34:11,450 So, how do you know when to do what? 704 00:34:13,187 --> 00:34:15,320 If you find the answer to that, let me know. 705 00:34:22,538 --> 00:34:24,238 - I have it. - You do? 706 00:34:24,307 --> 00:34:27,108 Dr. Glassman used varicella zoster virus 707 00:34:27,176 --> 00:34:29,877 as the delivery mechanism, which didn't work. 708 00:34:29,946 --> 00:34:31,913 His first choice was herpes simplex, 709 00:34:31,981 --> 00:34:33,514 but the technology was not up 710 00:34:33,582 --> 00:34:35,283 to putting their DNA package into it. 711 00:34:35,384 --> 00:34:37,585 The technology has improved. 712 00:34:37,787 --> 00:34:39,987 It can be done. 713 00:34:45,654 --> 00:34:47,186 Using conventional treatments, 714 00:34:47,289 --> 00:34:48,822 there's nothing more we can do for you. 715 00:34:48,890 --> 00:34:51,658 The pain will be permanent, and it could get worse. 716 00:34:52,961 --> 00:34:57,664 Well, I've not been one to be limited by the conventional. 717 00:34:57,732 --> 00:34:59,799 We think we can reverse the CRISPR. 718 00:34:59,869 --> 00:35:03,133 You want to reverse what I did? My telomerase change? 719 00:35:03,295 --> 00:35:03,965 They want to stop your pain. 720 00:35:04,068 --> 00:35:05,835 Soph, it's temporary. 721 00:35:05,937 --> 00:35:07,403 What is it, 40 years? 722 00:35:07,471 --> 00:35:10,862 That's nothing. Our real lives are ahead of us. 723 00:35:11,062 --> 00:35:13,295 Hey, look, as long as this doesn't kill me, 724 00:35:13,363 --> 00:35:16,464 I've made the right choice, no matter how bad things get. 725 00:35:16,566 --> 00:35:17,332 No. 726 00:35:18,869 --> 00:35:23,838 I was willing to exercise for hours and fast, 727 00:35:23,907 --> 00:35:26,107 to give up all sugar and alcohol 728 00:35:26,209 --> 00:35:28,576 and do all the other things that we needed to do 729 00:35:28,645 --> 00:35:33,515 to get to a future that I knew might never come. 730 00:35:33,583 --> 00:35:37,652 But now, you're asking me to watch you suffer 731 00:35:37,721 --> 00:35:39,420 for the rest of your life. 732 00:35:49,011 --> 00:35:53,415 You're the one who embraces change. 733 00:35:53,483 --> 00:35:58,753 So, change to the person who can be happy with me... 734 00:35:58,855 --> 00:36:00,755 here and now. 735 00:36:09,065 --> 00:36:11,399 Doctors, would you mind waiting outside? 736 00:36:18,766 --> 00:36:21,767 Why did she want us to leave? 737 00:36:21,835 --> 00:36:23,669 I think she's delivering an ultimatum. 738 00:36:36,410 --> 00:36:37,908 Are you sure about this? 739 00:36:39,445 --> 00:36:41,980 It seems there's always something else 740 00:36:41,982 --> 00:36:43,615 that I have to give up. 741 00:36:45,952 --> 00:36:48,073 But this isn't like sugar or cigarettes. 742 00:36:48,309 --> 00:36:50,676 You won't get over this in a hurry. 743 00:36:50,778 --> 00:36:52,812 No. 744 00:36:52,914 --> 00:36:54,446 Not in 1,000 years. 745 00:37:05,127 --> 00:37:05,958 Are you gonna be okay? 746 00:37:06,803 --> 00:37:07,875 I'm fine. 747 00:37:08,075 --> 00:37:10,129 Alan's at work, but there should be a taxi waiting. 748 00:37:11,235 --> 00:37:12,798 I won't say goodbye, Dr. Browne, 749 00:37:12,867 --> 00:37:16,368 'cause I'll probably be seeing you again pretty soon. 750 00:37:20,277 --> 00:37:21,841 I sent your cab away. 751 00:37:23,123 --> 00:37:24,376 I'm sorry I wasn't here sooner. 752 00:37:25,950 --> 00:37:27,947 I had to present a proposal to my partners. 753 00:37:36,973 --> 00:37:38,607 I'm selling them my share of the business. 754 00:37:43,170 --> 00:37:44,679 Is... Is there something else you want to do? 755 00:37:47,418 --> 00:37:48,234 Yes. 756 00:37:50,667 --> 00:37:52,410 I want to be your husband. 757 00:37:59,393 --> 00:38:03,029 I realized I was so... 758 00:38:03,097 --> 00:38:08,300 afraid of losing you in the future... 759 00:38:08,369 --> 00:38:09,635 I was losing you now. 760 00:38:38,376 --> 00:38:39,742 Sorry. 761 00:38:39,811 --> 00:38:42,445 I hear your VC contact decided to quit the business. 762 00:38:44,950 --> 00:38:46,482 He did the right thing. 763 00:38:53,458 --> 00:38:56,159 You know... 764 00:38:56,227 --> 00:38:58,828 my feet are killing me. 765 00:39:21,890 --> 00:39:24,791 I'm open. To being friends. 766 00:39:24,893 --> 00:39:25,958 That's great. 767 00:39:26,060 --> 00:39:29,295 I'm open, too, to wherever this goes. 768 00:39:29,331 --> 00:39:31,697 It's going to friendship. 769 00:39:31,766 --> 00:39:33,566 Understood. 770 00:39:33,635 --> 00:39:34,867 But life is about change, 771 00:39:34,936 --> 00:39:36,469 which means, one day, you might change your mind. 772 00:39:36,538 --> 00:39:38,872 And if you did, I'd be open to that, too. 773 00:39:38,974 --> 00:39:40,407 It's not gonna happen. 774 00:39:43,876 --> 00:39:45,234 Okay. 775 00:40:05,390 --> 00:40:07,556 First, there should be no soap involved. 776 00:40:07,625 --> 00:40:09,392 Also, we need to stay at one end of the shower, 777 00:40:09,461 --> 00:40:12,662 so we don't accidentally knock into the temperature control. 778 00:40:13,567 --> 00:40:16,134 What changed your mind? 779 00:40:16,236 --> 00:40:19,070 I've been thinking about change over time. 780 00:40:19,172 --> 00:40:20,939 I spoke with people and also graphed 781 00:40:21,007 --> 00:40:22,473 several possibilities for us, 782 00:40:22,543 --> 00:40:24,242 using time as the horizontal axis 783 00:40:24,311 --> 00:40:25,476 and change as the vertical. 784 00:40:25,546 --> 00:40:28,547 I realized that the problem isn't really change. 785 00:40:28,582 --> 00:40:32,583 It's whether two people change in the same direction. 786 00:40:32,652 --> 00:40:34,786 We want to keep our coordinates close to each other 787 00:40:34,888 --> 00:40:37,589 for the rest of our lives. 788 00:40:37,658 --> 00:40:40,358 We certainly do. 789 00:40:40,427 --> 00:40:43,494 But people sometimes do drift apart. 790 00:40:44,378 --> 00:40:44,695 Yes. 791 00:40:44,765 --> 00:40:46,865 You need a warning when you and your partner 792 00:40:47,630 --> 00:40:48,962 might be starting to veer off, 793 00:40:49,031 --> 00:40:50,631 so you can both change course a little. 794 00:40:50,699 --> 00:40:52,799 You don't want a surprise realization when it's too late. 795 00:40:52,901 --> 00:40:54,200 Surprises are awful. 796 00:40:54,236 --> 00:40:57,237 The U.S. Army Signal Corps used flags to warn of hurricanes. 797 00:40:57,339 --> 00:40:59,205 I brought us this. 798 00:41:00,805 --> 00:41:02,009 A cowbell? 799 00:41:02,660 --> 00:41:05,661 If you see us heading in different directions, 800 00:41:05,763 --> 00:41:06,896 you ring it. 801 00:41:06,964 --> 00:41:09,399 Do we really need a bell? Can't I just tell you? 802 00:41:10,602 --> 00:41:12,735 Oh! When you ring it, I'll pay attention. 803 00:41:12,837 --> 00:41:14,237 I really hate the sound. 804 00:41:14,305 --> 00:41:17,640 Only in emergencies. 805 00:41:17,709 --> 00:41:22,111 I've already moved the shampoo bottles. 806 00:41:22,213 --> 00:41:23,279 What? 807 00:41:26,985 --> 00:41:28,651 You mean now? 808 00:41:32,803 --> 00:41:34,970 Don't worry about putting the bottles back. 809 00:41:35,072 --> 00:41:36,004 I'll do it later. 810 00:41:37,141 --> 00:41:39,207 I love you. 811 00:41:39,309 --> 00:41:41,876 It's no trouble. I remember where they all go. 59965

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