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1
00:00:16,666 --> 00:00:19,867
We can't both shower
at the same time, Lea.
2
00:00:19,902 --> 00:00:22,503
One of us would block the
steam of water for the other.
3
00:00:22,605 --> 00:00:24,905
Oh, Shaun, this is not for
the purpose of cleanliness.
4
00:00:24,974 --> 00:00:27,574
This is for the purpose
of having sex with you.
5
00:00:29,178 --> 00:00:30,778
Oh.
6
00:00:30,880 --> 00:00:32,312
N-No. No.
7
00:00:32,381 --> 00:00:34,815
It would be inconvenient,
possibly dangerous.
8
00:00:34,884 --> 00:00:37,084
Soap might get into difficult places.
9
00:00:37,153 --> 00:00:38,619
If we leaned against the shower handle,
10
00:00:38,688 --> 00:00:39,653
we could scald ourselves.
11
00:00:39,721 --> 00:00:42,056
Bottles could be disarranged.
12
00:00:42,124 --> 00:00:43,824
It was just a thought.
13
00:00:43,926 --> 00:00:45,793
It was a bad thought.
14
00:00:45,895 --> 00:00:46,894
I'm surprised.
15
00:00:46,963 --> 00:00:48,495
You're such an intelligent person.
16
00:00:50,838 --> 00:00:53,372
I'll... reset your alarm.
17
00:00:57,044 --> 00:00:59,412
It's a three-day
weekend and a full moon.
18
00:00:59,480 --> 00:01:00,913
People are gonna do stupid things.
19
00:01:00,982 --> 00:01:03,816
I'm asking everyone to take
an extra trauma call in the E.R.
20
00:01:03,885 --> 00:01:05,884
Make yourselves
available if you're needed.
21
00:01:05,986 --> 00:01:07,820
Questions?
22
00:01:08,679 --> 00:01:10,512
How'd you get the bruise?
23
00:01:10,581 --> 00:01:11,747
First casualty of the full moon.
24
00:01:11,849 --> 00:01:13,114
I smacked my head on a cupboard door
25
00:01:13,184 --> 00:01:14,583
when I was reaching for my coffee mug.
26
00:01:14,685 --> 00:01:15,784
Any other questions?
27
00:01:15,852 --> 00:01:18,853
Why is there a Subaru
in your parking space?
28
00:01:18,922 --> 00:01:20,321
Because it's my car.
29
00:01:20,391 --> 00:01:21,323
You have a car?
30
00:01:21,392 --> 00:01:22,291
You're gonna be seeing a lot of it.
31
00:01:22,393 --> 00:01:23,291
I sold the Ducati.
32
00:01:23,360 --> 00:01:24,259
What? No.
33
00:01:24,328 --> 00:01:25,460
It just wasn't practical.
34
00:01:25,529 --> 00:01:26,661
Is it already gone? Because...
35
00:01:26,764 --> 00:01:29,063
A guy from Craigslist snatched it up.
36
00:01:29,166 --> 00:01:32,033
Any other questions...
not dealing with the bike?
37
00:01:33,937 --> 00:01:35,670
It wasn't that much of a bruise.
38
00:01:36,807 --> 00:01:39,074
But the doctor at the ski resort told us
39
00:01:39,143 --> 00:01:40,709
I might develop a hematoma?
40
00:01:40,778 --> 00:01:43,745
It's not unusual, but
it'll need to be drained.
41
00:01:44,334 --> 00:01:47,135
I see you were treated for
melanoma six years ago,
42
00:01:47,204 --> 00:01:49,104
and, more recently, breast cancer.
43
00:01:49,205 --> 00:01:50,604
Hence the ski trip.
44
00:01:50,707 --> 00:01:52,741
A celebration.
45
00:01:52,809 --> 00:01:56,272
One year cancer-free.
Also five years cancer-free.
46
00:01:57,514 --> 00:02:01,349
I don't suppose a long
needle will be involved in this?
47
00:02:01,451 --> 00:02:03,284
Your hematoma extends pretty deep,
48
00:02:03,353 --> 00:02:04,853
so the needle will have to be long.
49
00:02:04,921 --> 00:02:06,487
But it's over quickly.
50
00:02:07,459 --> 00:02:09,324
Sorry, I have to intervene
before this deal goes south.
51
00:02:09,426 --> 00:02:12,928
You don't mind if I step out?
52
00:02:12,997 --> 00:02:15,530
Would you like us to wait for
your husband to come back?
53
00:02:15,633 --> 00:02:17,299
No.
54
00:02:17,401 --> 00:02:18,533
Let's go ahead.
55
00:02:22,173 --> 00:02:24,040
How do you get frostbite in San Jose?
56
00:02:24,142 --> 00:02:25,274
Cryotherapy accident.
57
00:02:25,343 --> 00:02:27,109
I stayed in the booth a little too long.
58
00:02:27,178 --> 00:02:29,178
I was going to stand outside
for the full three minutes,
59
00:02:29,246 --> 00:02:30,812
- but he said...
- I said, "No need."
60
00:02:30,915 --> 00:02:32,648
I'd set the stopwatch on my phone...
61
00:02:32,717 --> 00:02:35,284
after which, my thoughts
immediately drifted, and...
62
00:02:35,352 --> 00:02:38,128
I came back to find
him frozen in carbonite.
63
00:02:38,572 --> 00:02:40,673
You know, I'm more
worried about the fever.
64
00:02:40,775 --> 00:02:43,006
Was the cryotherapy
meant to treat something?
65
00:02:43,106 --> 00:02:44,290
No. Routine self-care.
66
00:02:44,390 --> 00:02:46,657
We've made life extension
part of our health regime...
67
00:02:46,757 --> 00:02:48,780
supplements, meditation, exercise.
68
00:02:49,472 --> 00:02:51,138
Three of my gaming apps have gone viral.
69
00:02:51,207 --> 00:02:53,974
I'm lucky enough to afford
basically whatever I want,
70
00:02:54,076 --> 00:02:56,110
so I spend it on my health.
71
00:02:56,212 --> 00:02:59,480
No, I figure fever,
must be an infection.
72
00:02:59,582 --> 00:03:02,450
Well, I know that frostbite
can make you vulnerable.
73
00:03:02,552 --> 00:03:07,488
It just... It didn't seem
severe enough to...
74
00:03:07,590 --> 00:03:10,190
Oh, sorry. I feel a little queasy.
75
00:03:11,394 --> 00:03:12,359
Wyatt.
76
00:03:21,838 --> 00:03:23,471
I need a medical transport team, stat.
77
00:03:23,573 --> 00:03:25,706
Perforated bowel. He
needs immediate surgery.
79
00:03:35,819 --> 00:03:37,885
No. No. Why do people hate wind farms?
80
00:03:37,987 --> 00:03:39,921
Everyone thinks they're noisy.
81
00:03:40,023 --> 00:03:41,556
This could make a turbine sound as quiet
82
00:03:41,658 --> 00:03:43,057
as a page turning in a library.
83
00:03:43,159 --> 00:03:44,525
That's not worth our investing in?
84
00:03:44,627 --> 00:03:46,093
Did you even look... Hold on.
85
00:03:46,195 --> 00:03:47,962
Anything I need to know?
86
00:03:48,064 --> 00:03:49,130
Hematoma's drained.
87
00:03:49,231 --> 00:03:51,031
We're sending a sample
to Pathology... routine.
88
00:03:51,133 --> 00:03:52,399
Should have it back sometime tomorrow.
89
00:03:52,501 --> 00:03:53,439
Thank you.
90
00:03:54,904 --> 00:03:57,237
I couldn't help overhearing a little.
91
00:03:57,340 --> 00:04:00,107
Are you a venture capitalist?
92
00:04:00,209 --> 00:04:02,343
The only people who ask me if I'm a VC
93
00:04:02,445 --> 00:04:05,112
are people who want a
VC to invest in their project.
94
00:04:06,916 --> 00:04:10,885
Maybe, after we get your wife
healthy again, we could talk?
95
00:04:10,987 --> 00:04:11,886
Call whenever you're ready.
96
00:04:11,988 --> 00:04:13,620
My life is listening to ideas.
97
00:04:13,722 --> 00:04:15,155
If it's good, I'll run it
by my two partners.
98
00:04:15,257 --> 00:04:16,356
If it's really good,
99
00:04:16,458 --> 00:04:18,525
we'll take a 30% equity
position in your company.
100
00:04:20,864 --> 00:04:22,229
Yeah.
101
00:04:22,331 --> 00:04:24,565
Yeah, you're the one who wanted
us to get into clean technology.
102
00:04:26,736 --> 00:04:28,669
I think I've been asked out on a date.
103
00:04:28,769 --> 00:04:29,869
_
104
00:04:30,673 --> 00:04:31,806
Nice.
105
00:04:31,908 --> 00:04:32,940
No, I work with him.
106
00:04:33,042 --> 00:04:34,875
- Hasn't stopped you before.
- I supervise him.
107
00:04:34,977 --> 00:04:35,943
Schedules can be changed.
108
00:04:36,045 --> 00:04:37,377
He's polyamorous.
109
00:04:37,479 --> 00:04:40,781
Unless he also texted
you a ring, it's just a date.
110
00:04:40,883 --> 00:04:42,416
And you need to get out more.
111
00:04:43,920 --> 00:04:45,019
So do I.
112
00:04:50,760 --> 00:04:53,795
You want to take
down the splenocolic ligament.
113
00:04:53,897 --> 00:04:56,798
Just don't nick the
inferior mesenteric artery.
114
00:04:56,900 --> 00:05:00,635
I feel the I.M.A. under my finger.
115
00:05:00,737 --> 00:05:03,004
Placing the stapler.
116
00:05:03,105 --> 00:05:05,072
And cutting.
117
00:05:05,174 --> 00:05:06,707
I voted "approve."
118
00:05:09,912 --> 00:05:11,312
Disapprove.
119
00:05:11,414 --> 00:05:13,147
No opinion.
120
00:05:13,249 --> 00:05:14,148
There's a poll?
121
00:05:14,250 --> 00:05:16,550
Yes... about shower sex.
122
00:05:16,652 --> 00:05:19,286
I know it's wrong to
discuss shower sex at work,
123
00:05:19,388 --> 00:05:20,988
so I did a poll instead.
124
00:05:21,090 --> 00:05:22,422
Much better.
125
00:05:22,524 --> 00:05:24,825
Dr. Murphy, do you really
want people knowing the details
126
00:05:24,927 --> 00:05:26,026
of your personal life?
127
00:05:26,128 --> 00:05:29,564
You don't think they took
it as an abstract question?
128
00:05:29,666 --> 00:05:32,600
No. We all take it as something
that happened between you and Lea.
129
00:05:32,702 --> 00:05:33,801
And that there was a fight.
130
00:05:33,903 --> 00:05:35,336
Sometime before 8:00 a.m. today,
131
00:05:35,438 --> 00:05:37,571
which was when the poll was sent out.
132
00:05:39,108 --> 00:05:40,741
You are very astute.
133
00:05:40,843 --> 00:05:43,978
I'm seeing diffuse dilation
of the large bowel here.
134
00:05:44,080 --> 00:05:46,346
Is that normal?
135
00:05:46,448 --> 00:05:49,750
Some calcified lesions.
136
00:05:49,852 --> 00:05:51,251
Wall's thin, too.
137
00:05:51,353 --> 00:05:52,419
Hirschsprung's.
138
00:05:52,521 --> 00:05:54,354
I thought Hirschsprung's
was a disease only babies
139
00:05:54,457 --> 00:05:55,455
and young children got.
140
00:05:55,557 --> 00:05:57,391
It is.
141
00:05:57,493 --> 00:05:58,625
But he has it.
142
00:06:06,268 --> 00:06:07,869
We treated the Hirschsprung's
143
00:06:07,971 --> 00:06:09,337
by removing the
dilated part of your colon.
144
00:06:09,440 --> 00:06:11,340
It won't impact your life,
145
00:06:11,442 --> 00:06:13,008
but we would like an explanation.
146
00:06:13,109 --> 00:06:14,376
Dr. Murphy doesn't mean
147
00:06:14,478 --> 00:06:16,011
we expect you to be a diagnostician.
148
00:06:16,112 --> 00:06:17,312
It's just...
149
00:06:17,414 --> 00:06:19,080
this was kind of singular.
150
00:06:19,182 --> 00:06:21,450
So, if you have any thoughts...
151
00:06:21,552 --> 00:06:24,820
Did anyone in your family
suddenly develop these symptoms?
152
00:06:28,772 --> 00:06:32,641
I did something singular to
myself about six months ago.
153
00:06:32,744 --> 00:06:35,410
I modified my genetic code.
154
00:06:35,513 --> 00:06:38,180
I did a CRISPR procedure under
the guidance of some researchers
155
00:06:38,282 --> 00:06:39,581
I know in China through my work.
156
00:06:39,683 --> 00:06:41,350
They put together a series of cocktails.
157
00:06:41,452 --> 00:06:45,754
They FedExed them to be, and
Sophie helped me inject them
158
00:06:45,856 --> 00:06:47,055
into my bone marrow.
159
00:06:47,158 --> 00:06:48,423
Why?
160
00:06:48,525 --> 00:06:49,824
If you know anything about CRISPR,
161
00:06:49,927 --> 00:06:51,927
you know how risky it is
to tinker with your genome.
162
00:06:52,029 --> 00:06:55,097
You have no idea what
problems you might let loose.
163
00:06:55,199 --> 00:06:57,299
I needed to optimize
my telomerase activity.
164
00:06:57,401 --> 00:06:58,934
It's the enzyme
responsible for correcting
165
00:06:59,036 --> 00:06:59,969
cell replication errors...
166
00:07:00,071 --> 00:07:01,136
essentially, the cause of aging.
167
00:07:01,238 --> 00:07:02,404
You can't stop aging
168
00:07:02,506 --> 00:07:04,506
through changing
your telomerase activity.
169
00:07:04,608 --> 00:07:08,177
You might extend your
life a little, but exercise...
170
00:07:08,279 --> 00:07:09,644
it does the same thing.
171
00:07:09,747 --> 00:07:10,645
Much less risky.
172
00:07:10,747 --> 00:07:12,248
Your decision makes no sense.
173
00:07:12,350 --> 00:07:15,884
Extending my life by a few
years is only my short-term goal.
174
00:07:15,987 --> 00:07:17,953
Look, you know how
fast medicine is moving.
175
00:07:18,055 --> 00:07:19,854
The day isn't that far away when cloning
176
00:07:19,957 --> 00:07:22,891
will make transplants as easy
as switching out a light socket.
177
00:07:22,993 --> 00:07:24,693
AI will start to make breakthroughs
178
00:07:24,795 --> 00:07:26,361
that we can't predict or understand.
179
00:07:26,463 --> 00:07:29,531
Medical knowledge
will rise exponentially.
180
00:07:29,633 --> 00:07:32,133
There are babies born
now who could live to see it,
181
00:07:32,236 --> 00:07:34,169
could live to be 1,000 years old.
182
00:07:34,271 --> 00:07:35,805
Maybe more. Maybe forever.
183
00:07:35,907 --> 00:07:38,440
Or at least, as long as they want to.
184
00:07:38,542 --> 00:07:40,875
So, our plan is to give my CRISPR a year
185
00:07:40,978 --> 00:07:42,944
to make sure the
telomerase change works,
186
00:07:43,047 --> 00:07:45,414
and then we'll do her.
187
00:07:47,150 --> 00:07:49,385
We'll aspirate a sample
of your bone marrow.
188
00:07:49,487 --> 00:07:51,253
See if we can figure
out what the hell you did.
189
00:07:58,895 --> 00:07:59,929
Hey.
190
00:08:00,031 --> 00:08:04,233
Um... I don't think coffee's a good idea.
191
00:08:04,335 --> 00:08:06,068
Entire civilizations rely on it.
192
00:08:06,170 --> 00:08:08,169
But I don't think you're
referring to the beverage itself.
193
00:08:08,272 --> 00:08:10,005
I don't think it's a
good idea for first-years
194
00:08:10,107 --> 00:08:11,340
and fourth-years to go out.
195
00:08:11,442 --> 00:08:14,309
I am bound to supervise
you at some point in the future,
196
00:08:14,411 --> 00:08:17,512
and it'd get complicated
trying to change dates out,
197
00:08:17,615 --> 00:08:20,449
and the fact is...
198
00:08:20,551 --> 00:08:23,418
seeing somebody you
work with rarely ends happily.
199
00:08:23,520 --> 00:08:25,487
So, I appreciate you
thinking of me, but I...
200
00:08:25,589 --> 00:08:28,723
Oh, you thought it was a date.
201
00:08:28,825 --> 00:08:30,492
I'm still new here, and I thought it was
202
00:08:30,594 --> 00:08:33,795
a good opportunity to
get to know each other.
203
00:08:33,897 --> 00:08:35,998
Coffee's perfect because you're asking
204
00:08:36,100 --> 00:08:38,767
the least amount of commitment
from another human being.
205
00:08:38,870 --> 00:08:40,835
It's not even lunch.
206
00:08:40,937 --> 00:08:42,871
If it's still a "no," it's still a "no,"
207
00:08:42,973 --> 00:08:45,407
but I'll let you re-think your answer.
208
00:08:48,269 --> 00:08:52,146
_
209
00:08:53,389 --> 00:08:54,994
_
210
00:08:55,094 --> 00:08:58,430
_
211
00:08:58,830 --> 00:09:01,223
He only claimed it
wasn't a date to save face.
212
00:09:01,292 --> 00:09:03,658
Or maybe I just assumed.
213
00:09:03,760 --> 00:09:04,926
But why did I assume?
214
00:09:05,028 --> 00:09:06,761
I don't think I'm
some kind of narcissist
215
00:09:06,830 --> 00:09:09,898
who thinks every man
wants to get close to me.
216
00:09:10,565 --> 00:09:13,933
Or we both assumed it's
a date because it's a date.
217
00:09:14,002 --> 00:09:16,035
This is fun. I like being your bestie.
218
00:09:16,137 --> 00:09:17,369
Slumber party?
219
00:09:23,749 --> 00:09:26,550
I made a poll to test the
popularity of shower sex.
220
00:09:26,652 --> 00:09:27,684
I heard.
221
00:09:27,753 --> 00:09:29,720
I fielded some questions about that.
222
00:09:29,788 --> 00:09:34,057
"Approve" has won, but
don't get too excited, Lea.
223
00:09:34,160 --> 00:09:36,426
It's only 58-38,
224
00:09:36,494 --> 00:09:38,929
with several complicated noncommittals,
225
00:09:38,997 --> 00:09:41,197
so clearly my attitude is reasonable.
226
00:09:41,266 --> 00:09:43,400
We don't have room for a...
227
00:09:43,469 --> 00:09:45,501
skier exercise thing.
228
00:09:45,571 --> 00:09:48,404
I'm only putting it together
so I can take a picture
229
00:09:48,473 --> 00:09:49,706
and sell it online.
230
00:09:50,702 --> 00:09:52,902
Why do you have it if you don't want it?
231
00:09:58,510 --> 00:10:02,078
My ex sent it.
232
00:10:02,180 --> 00:10:03,813
"Ex"?
233
00:10:03,915 --> 00:10:06,649
Husband.
234
00:10:07,267 --> 00:10:09,034
I left this thing in the attic
235
00:10:09,102 --> 00:10:11,202
until I got settled somewhere
with enough space.
236
00:10:11,271 --> 00:10:12,937
And okay, that was 10 years ago,
237
00:10:13,006 --> 00:10:14,539
but it's not like it was in his way.
238
00:10:18,211 --> 00:10:22,313
We got married, not for
long, right out of high school.
239
00:10:22,382 --> 00:10:23,948
Literally the boy next door.
240
00:10:24,017 --> 00:10:25,983
We grew up together. People expected it.
241
00:10:26,052 --> 00:10:29,087
It... was a big mistake.
242
00:10:29,155 --> 00:10:31,740
We both realized it pretty quickly.
243
00:10:36,807 --> 00:10:38,806
Why would you
even want to live forever?
244
00:10:38,875 --> 00:10:40,108
You'd be bored out of your mind.
245
00:10:41,278 --> 00:10:42,544
The person I am now
246
00:10:42,612 --> 00:10:47,115
is miles away from
the person I was at 14.
247
00:10:47,217 --> 00:10:50,418
I only get more distant every year.
248
00:10:50,487 --> 00:10:54,589
You learn to understand,
249
00:10:54,658 --> 00:10:58,260
love books that you once hated,
250
00:10:58,328 --> 00:11:01,029
sometimes people you once hated.
251
00:11:01,098 --> 00:11:05,633
Music that you didn't get
the point of becomes magical.
252
00:11:06,671 --> 00:11:08,836
And a thousand new doors will open.
253
00:11:08,936 --> 00:11:09,971
I look forward to the adventure.
254
00:11:12,186 --> 00:11:14,754
Sorry. Adventure's not
always gonna be fun.
255
00:11:16,157 --> 00:11:19,525
I figure it takes 40 or 50 years
256
00:11:19,594 --> 00:11:21,961
just to get over the
things your parents did.
257
00:11:22,029 --> 00:11:24,242
If only we lived long enough,
258
00:11:24,342 --> 00:11:28,083
the human race might finally
have a chance to grow up.
259
00:11:34,917 --> 00:11:37,385
What size shoes do you wear?
260
00:11:37,453 --> 00:11:39,887
71/2.
261
00:11:39,989 --> 00:11:41,989
"Dr. Allen's Walking On Clouds Inserts."
262
00:11:42,058 --> 00:11:44,358
Putting "doctor" in the name is
always good marketing strategy.
263
00:11:44,427 --> 00:11:46,960
They're designed to reduce inflammation
264
00:11:47,029 --> 00:11:49,030
that could lead to plantar fasciitis,
265
00:11:49,132 --> 00:11:51,832
calluses, arthritis, and
they feel damn good.
266
00:11:51,901 --> 00:11:53,634
Does this have anything
to do with our patient's
267
00:11:53,703 --> 00:11:54,835
venture capitalist husband?
268
00:11:54,904 --> 00:11:56,337
I need testimonials.
269
00:11:56,405 --> 00:11:57,838
Labs and Path for Hannah Palmer.
270
00:12:01,077 --> 00:12:03,877
Aren't we all busy enough
learning how to be surgeons?
271
00:12:03,913 --> 00:12:06,447
Do you really want to divide
your focus onto something trivial?
272
00:12:12,340 --> 00:12:15,475
Because wanting to make
money taints the purity of medicine?
273
00:12:17,312 --> 00:12:18,845
I have five brothers.
274
00:12:18,880 --> 00:12:21,147
I've been taking care
of people my whole life.
275
00:12:21,215 --> 00:12:24,584
Someone got hurt, they
came to me to patch them up.
276
00:12:24,652 --> 00:12:27,787
I became a doctor so
I could get paid for it,
277
00:12:27,856 --> 00:12:30,890
but also because I'm good
at taking care of people.
278
00:12:30,925 --> 00:12:33,125
It's possible to do something
for more than one reason.
279
00:12:44,439 --> 00:12:46,460
The news is bad.
280
00:12:55,651 --> 00:12:58,819
There's an abnormally healthy population
281
00:12:58,887 --> 00:13:01,788
of hematopoietic progenitor stem cells.
282
00:13:01,857 --> 00:13:02,889
He did it?
283
00:13:02,958 --> 00:13:04,090
It's significant.
284
00:13:04,159 --> 00:13:07,026
He's succeeded in optimizing
enough telomerase activity
285
00:13:07,095 --> 00:13:10,138
to potentially add 10
years to his natural life.
286
00:13:10,191 --> 00:13:12,528
Well, assuming
it doesn't subtract about 50.
287
00:13:12,561 --> 00:13:14,184
There's already an autoimmune reaction
288
00:13:14,284 --> 00:13:15,427
that mimics Hirschsprung's.
289
00:13:15,571 --> 00:13:15,979
Who knows what else he did?
290
00:13:16,048 --> 00:13:18,516
What if this is the opposite
of an auto-immune condition?
291
00:13:18,584 --> 00:13:19,550
What if he's done something
292
00:13:19,619 --> 00:13:22,109
that lowers his resistance to infection?
293
00:13:22,194 --> 00:13:24,742
Then we'd be seeing
more opportunistic infections
294
00:13:24,792 --> 00:13:25,638
of the lungs and skin.
295
00:13:26,155 --> 00:13:27,888
If you lived another 1,000 years,
296
00:13:27,988 --> 00:13:30,206
would you be with the
same person at the end
297
00:13:30,275 --> 00:13:31,394
as at the beginning?
298
00:13:31,858 --> 00:13:31,962
- No.
- No.
299
00:13:34,080 --> 00:13:35,546
No, if you assume monogamy.
300
00:13:35,615 --> 00:13:37,481
I mean, that puts too much
strain on a relationship.
301
00:13:37,551 --> 00:13:39,451
Is one person supposed
to be everything to another,
302
00:13:39,519 --> 00:13:41,218
all the time, for 1,000 years?
303
00:13:41,320 --> 00:13:44,989
Apparently Jesus agrees. On monogamy.
304
00:13:45,058 --> 00:13:47,191
He said that, in Heaven,
there'll be no more marriages.
305
00:13:47,260 --> 00:13:50,494
I guess humans can't
sustain a relationship that long.
306
00:13:50,596 --> 00:13:51,863
You read the New Testament, too?
307
00:13:51,932 --> 00:13:54,499
And the Qur'an. And other things.
308
00:13:54,568 --> 00:13:55,667
It's like you're a stalker.
309
00:13:55,735 --> 00:13:58,135
It's like you and God had
an acrimonious divorce.
310
00:13:58,204 --> 00:14:01,673
What if he caused neurofibromatosis?
311
00:14:01,741 --> 00:14:03,842
Microscopic tumors
forming on the nerve sheath?
312
00:14:04,802 --> 00:14:06,200
Possible, but there'd have been
313
00:14:06,269 --> 00:14:07,502
some evidence of Schwann cell growth
314
00:14:07,605 --> 00:14:08,737
around his colon.
315
00:14:08,806 --> 00:14:11,506
Would you still love
your wife in 1,000 years?
316
00:14:13,277 --> 00:14:15,243
You have three answers.
That should be enough.
317
00:14:15,311 --> 00:14:17,512
Park's marriage failed in far less time,
318
00:14:17,581 --> 00:14:19,047
and Enrique doesn't even try.
319
00:14:19,149 --> 00:14:20,649
Asher is an...
320
00:14:20,717 --> 00:14:22,050
unknown quantity.
321
00:14:22,152 --> 00:14:23,618
You're committed.
322
00:14:23,687 --> 00:14:25,020
You've made promises.
323
00:14:27,390 --> 00:14:29,324
I've made promises based on
324
00:14:29,392 --> 00:14:32,994
an understood human life-span, Murphy.
325
00:14:33,766 --> 00:14:36,700
Most likely diagnosis is
autoimmune polyneuropathy.
326
00:14:36,802 --> 00:14:38,369
It damaged the enteral ganglion nerve
327
00:14:38,438 --> 00:14:39,737
and led to the perforations.
328
00:14:39,805 --> 00:14:42,439
Start him on steroids
and immunosuppressants.
329
00:14:42,542 --> 00:14:43,807
Dr. Andrews.
330
00:14:43,909 --> 00:14:45,676
So, you wouldn't have gotten married
331
00:14:45,778 --> 00:14:47,445
if you thought it would be forever.
332
00:14:47,513 --> 00:14:50,147
You expect all
relationships to fail over time.
333
00:14:50,216 --> 00:14:51,948
It's just a question of how long?
334
00:14:53,786 --> 00:14:55,853
I love her now.
335
00:14:55,921 --> 00:15:00,157
I intend to love her as long as I live.
336
00:15:00,226 --> 00:15:04,795
But, eventually, everything breaks.
337
00:15:14,299 --> 00:15:15,499
I always go back to comfort reading
338
00:15:15,600 --> 00:15:16,766
when I'm in the hospital.
339
00:15:16,835 --> 00:15:18,635
Cozy mysteries in
little English villages,
340
00:15:18,703 --> 00:15:21,004
where nothing bad
happens to anyone we like.
341
00:15:22,774 --> 00:15:24,607
We've gotten your results back.
342
00:15:24,676 --> 00:15:25,642
When will your husband be...
343
00:15:25,711 --> 00:15:26,910
Is it cancer?
344
00:15:29,314 --> 00:15:30,447
Yes.
345
00:15:32,551 --> 00:15:34,951
Thyroid carcinoma.
346
00:15:35,019 --> 00:15:36,819
We're gonna do a complete imaging series
347
00:15:36,888 --> 00:15:37,987
to pinpoint just how advanced...
348
00:15:38,056 --> 00:15:39,989
Treatment?
349
00:15:40,538 --> 00:15:43,740
Surgery to remove
some or all of your thyroid
350
00:15:43,842 --> 00:15:46,108
is usually the first line of defense.
351
00:15:46,210 --> 00:15:48,678
Sometimes, we can wait,
but given the hematoma
352
00:15:48,780 --> 00:15:52,815
was probably caused by the
tumor invading nearby vasculatures,
353
00:15:52,884 --> 00:15:55,217
we should probably do
it in the next few days.
354
00:15:55,319 --> 00:15:58,487
Later, there'll be
radioactive iodine treatment...
355
00:16:00,258 --> 00:16:01,524
Panic attack?
356
00:16:07,398 --> 00:16:08,631
Her trachea's deviated to the right.
357
00:16:08,733 --> 00:16:11,067
The tumor's compressing
it. We're doing surgery now.
358
00:16:22,654 --> 00:16:24,087
What happened? The
nurse just said "surgery."
359
00:16:24,189 --> 00:16:26,590
Was it the hematoma?
360
00:16:26,658 --> 00:16:28,025
It's more serious.
361
00:16:29,761 --> 00:16:32,095
I-It's not cancer...
362
00:16:32,197 --> 00:16:33,730
again.
363
00:16:33,799 --> 00:16:36,433
Thyroid carcinoma.
364
00:16:36,501 --> 00:16:39,268
We've removed her
thyroid. She's doing well.
365
00:16:39,338 --> 00:16:41,004
We're looking into potential causes...
366
00:16:41,072 --> 00:16:42,772
genetic, environmental.
367
00:16:42,841 --> 00:16:47,293
There may be a deeper issue
that we can find and address.
368
00:16:57,820 --> 00:17:01,288
I can't do this.
369
00:17:01,390 --> 00:17:03,924
You've done it before.
370
00:17:04,026 --> 00:17:06,259
You'll do it this time.
371
00:17:11,200 --> 00:17:13,667
Do you know what it's like...
372
00:17:13,736 --> 00:17:15,235
to wake up every
morning and know your wife
373
00:17:15,304 --> 00:17:16,803
might not be here next year?
374
00:17:19,890 --> 00:17:22,858
All those treatments...
375
00:17:22,926 --> 00:17:26,194
they all... they all have this
little tag attached to them
376
00:17:26,296 --> 00:17:29,530
that says, "Because she might die."
377
00:17:29,599 --> 00:17:33,001
And you see them put those gloves on
378
00:17:33,103 --> 00:17:34,202
before they hook up the chemo.
379
00:17:34,271 --> 00:17:36,971
You know why they do that.
380
00:17:37,040 --> 00:17:38,840
It's because it's poison.
381
00:17:41,044 --> 00:17:43,712
And you sit there...
382
00:17:43,780 --> 00:17:47,415
and you watch them shove
poison into the person you love.
383
00:17:47,517 --> 00:17:50,351
And why?
384
00:17:50,420 --> 00:17:52,587
Because she might die.
385
00:17:54,858 --> 00:17:57,492
We're killing her because she might die.
386
00:18:03,223 --> 00:18:04,422
Go for a run.
387
00:18:04,491 --> 00:18:07,091
Go punch a wall.
388
00:18:07,160 --> 00:18:08,826
You need to release some endorphins.
389
00:18:08,895 --> 00:18:10,595
My release is my job.
390
00:18:10,697 --> 00:18:12,296
That's why I love it.
391
00:18:12,398 --> 00:18:15,066
My work requires total focus.
392
00:18:15,168 --> 00:18:16,334
And every minute I'm working
393
00:18:16,402 --> 00:18:19,103
is a minute I'm not thinking about...
394
00:18:19,205 --> 00:18:20,304
losing her.
395
00:18:26,145 --> 00:18:27,575
I have to go.
396
00:18:33,801 --> 00:18:36,869
Your pain and weakness are
consistent with polyneuropathy,
397
00:18:36,937 --> 00:18:39,404
treatable with steroids
and immunosuppressants.
398
00:18:39,473 --> 00:18:42,574
If you live 1,000 years,
will you still love Sophie?
399
00:18:45,012 --> 00:18:46,044
Yes.
400
00:18:46,147 --> 00:18:47,846
How can you be sure?
401
00:18:47,915 --> 00:18:50,415
People change. You expect to change.
402
00:18:50,484 --> 00:18:53,652
Sophie and I will change together.
403
00:18:53,721 --> 00:18:55,497
We'll go through the same adventures
404
00:18:55,570 --> 00:18:56,575
and learn the same lessons.
405
00:18:56,775 --> 00:18:58,423
What if you go through
the same adventures
406
00:18:58,492 --> 00:18:59,925
and learn different lessons?
407
00:19:00,819 --> 00:19:03,720
Even if we did, whoever,
whatever we become,
408
00:19:03,789 --> 00:19:05,387
Sophie will always be beautiful.
409
00:19:05,456 --> 00:19:08,024
I mean, she could turn into
a machine or a set of pixels
410
00:19:08,093 --> 00:19:10,860
or a giant purple flower,
and she'll still be beautiful,
411
00:19:10,962 --> 00:19:13,830
because it's part of
her essential nature.
412
00:19:16,968 --> 00:19:19,268
But if you don't know how you'll change,
413
00:19:19,337 --> 00:19:21,003
you don't know how you'll change.
414
00:19:21,105 --> 00:19:23,472
Shaun.
415
00:19:23,574 --> 00:19:24,841
We'll let you get some rest.
416
00:19:24,943 --> 00:19:27,076
The steroids should
make you feel a lot better.
417
00:19:33,901 --> 00:19:39,004
Why didn't you ever mention
you had an ex-husband?
418
00:19:39,073 --> 00:19:42,941
Shaun, I've barely
thought about him in years.
419
00:19:43,010 --> 00:19:46,812
I didn't mention him
because he's not important.
420
00:19:46,881 --> 00:19:49,748
I know. That's the problem.
421
00:19:49,817 --> 00:19:52,718
At one time, you felt he was
important enough to your life
422
00:19:52,787 --> 00:19:56,321
to marry him, and now
you barely think of him.
423
00:19:56,390 --> 00:19:59,892
You make long-term plans,
you have expectations,
424
00:19:59,960 --> 00:20:01,594
and then something happens to you,
425
00:20:01,662 --> 00:20:05,898
and suddenly you're a different person.
426
00:20:06,684 --> 00:20:11,588
I know you don't like
change, but it's not all bad.
427
00:20:11,656 --> 00:20:15,892
After all, you are working to
change yourself all the time.
428
00:20:15,960 --> 00:20:21,864
I'm working to be a better
surgeon, a better boyfriend,
429
00:20:21,966 --> 00:20:24,333
better at the things I've chosen,
430
00:20:24,436 --> 00:20:28,142
but this... other change...
it's unpredictable.
431
00:20:28,228 --> 00:20:29,163
You don't choose it.
432
00:20:29,237 --> 00:20:30,476
It just comes at you.
433
00:20:31,218 --> 00:20:33,785
Oh, it's like hurricanes before 1873,
434
00:20:33,887 --> 00:20:35,821
when the Army Signal
Corps first put up flags
435
00:20:35,890 --> 00:20:37,389
to warn people storms were coming.
436
00:20:37,458 --> 00:20:39,992
Before that, houses were
flattened, lives destroyed,
437
00:20:40,094 --> 00:20:42,394
and there was no way to
see it was heading for you.
438
00:20:42,496 --> 00:20:44,463
Shaun.
439
00:20:44,532 --> 00:20:48,134
Our relationship will not
end in natural disaster.
440
00:20:48,202 --> 00:20:49,634
It did begin in one.
441
00:20:52,006 --> 00:20:54,974
I'm going to look in on my patient.
442
00:20:55,042 --> 00:20:56,909
Okay.
443
00:21:04,415 --> 00:21:07,817
Blood and saliva will tell
us if there's a genetic cause,
444
00:21:07,886 --> 00:21:09,585
and the samples we take from your house
445
00:21:09,655 --> 00:21:11,620
will tell us if there's
something environmental.
446
00:21:13,491 --> 00:21:16,826
I know it's s-stupid.
447
00:21:16,928 --> 00:21:19,362
I've almost felt guilty for my cancer,
448
00:21:19,430 --> 00:21:23,699
like I arbitrarily decided
to be sick and burdensome.
449
00:21:26,104 --> 00:21:27,503
Do the people you're close to
450
00:21:27,572 --> 00:21:30,239
ever act like you're a burden to them?
451
00:21:31,272 --> 00:21:32,405
You mean Alan.
452
00:21:34,643 --> 00:21:36,442
He's scared.
453
00:21:36,511 --> 00:21:40,647
He takes the exit he's got
and he turns to his work.
454
00:21:40,716 --> 00:21:42,415
You're okay with that?
455
00:21:49,791 --> 00:21:52,125
I accept this compromise.
456
00:21:52,193 --> 00:21:53,159
That's not the hard part.
457
00:21:53,228 --> 00:21:55,194
The hard part is...
458
00:21:55,296 --> 00:21:58,297
not knowing.
459
00:21:58,366 --> 00:22:02,836
Each new thing that
happens, I worry, "Is this it?
460
00:22:02,938 --> 00:22:06,005
Is this where I lose him?
461
00:22:06,074 --> 00:22:07,841
Is this where he breaks?"
462
00:22:15,966 --> 00:22:18,401
So, this is boiled coffee.
463
00:22:18,469 --> 00:22:20,102
Some people call it "Turkish coffee,"
464
00:22:20,204 --> 00:22:23,071
or "Greek coffee,"
or "Egyptian coffee"...
465
00:22:23,140 --> 00:22:24,340
because we need to take ownership
466
00:22:24,409 --> 00:22:25,874
and put things in categories.
467
00:22:25,976 --> 00:22:27,576
Yeah.
468
00:22:27,678 --> 00:22:29,111
You actually live in this thing,
469
00:22:29,179 --> 00:22:31,280
in the hospital parking garage?
470
00:22:31,382 --> 00:22:32,448
Why not?
471
00:22:32,550 --> 00:22:33,715
Convenient for work.
472
00:22:33,784 --> 00:22:36,118
When I want to spend a
few days off the beaten track,
473
00:22:36,187 --> 00:22:38,320
it's convenient for that, too.
474
00:22:38,389 --> 00:22:41,022
I'm gonna get three sips in this.
475
00:22:41,091 --> 00:22:43,058
But three really great sips.
476
00:22:44,729 --> 00:22:46,562
That's how I try to live my life...
477
00:22:46,664 --> 00:22:50,799
try to appreciate, savor, not pass by.
478
00:22:54,389 --> 00:22:57,457
Is that what the polyamory is about?
479
00:22:57,526 --> 00:23:00,193
Does it really work, or is it
one of those theories about life
480
00:23:00,295 --> 00:23:02,028
that people regret later?
481
00:23:02,097 --> 00:23:03,196
No regrets so far.
482
00:23:03,265 --> 00:23:04,765
No, I guess not.
483
00:23:04,833 --> 00:23:08,034
Not while you're young and having fun.
484
00:23:08,103 --> 00:23:09,336
It is fun,
485
00:23:09,438 --> 00:23:11,104
but not for the reasons
that you're thinking.
486
00:23:11,206 --> 00:23:13,339
It isn't about sex.
487
00:23:13,441 --> 00:23:16,242
It's about commitment,
emotional connection.
488
00:23:16,311 --> 00:23:18,545
The joy I'm sure you
get out of a relationship,
489
00:23:18,647 --> 00:23:19,546
I get a little more.
490
00:23:19,648 --> 00:23:21,648
Also, I have to give a little more.
491
00:23:21,717 --> 00:23:24,217
But that's meaningful, too.
492
00:23:26,888 --> 00:23:28,488
Do you mind if I ask you something,
493
00:23:28,557 --> 00:23:30,256
since we're getting personal?
494
00:23:34,853 --> 00:23:36,218
Sure.
495
00:23:36,320 --> 00:23:38,721
What's your favorite
misheard song lyric?
496
00:23:47,131 --> 00:23:48,531
This is nice.
497
00:23:50,535 --> 00:23:52,969
I'm glad it's not a date.
498
00:23:53,071 --> 00:23:54,503
Me, too.
499
00:23:54,605 --> 00:23:56,372
I don't believe in those categories.
500
00:24:00,879 --> 00:24:03,345
He reported widespread bilateral pain,
501
00:24:03,447 --> 00:24:04,347
then he keeled over.
502
00:24:04,449 --> 00:24:05,715
B.P. dropped to 80 over palp.
503
00:24:05,817 --> 00:24:06,849
I'll order a vasopressor.
504
00:24:06,951 --> 00:24:08,284
- Already did.
- Good.
505
00:24:08,386 --> 00:24:12,221
We need an EKG, CBC, and
chest images, and a new diagnosis.
506
00:24:12,323 --> 00:24:15,024
Whatever he caused with
CRISPR, it's not just neuropathy.
507
00:24:15,126 --> 00:24:16,993
Something else is killing him.
508
00:24:23,447 --> 00:24:25,247
What if he's caused
something that mimics
509
00:24:25,347 --> 00:24:26,871
carcinomatous autonomic neuropathy?
510
00:24:27,411 --> 00:24:29,444
It explains the B.P. and bowel issue.
511
00:24:29,948 --> 00:24:32,693
That doesn't explain the sensory
issue that led to the frostbite.
512
00:24:36,076 --> 00:24:37,575
A connective tissue disorder?
513
00:24:37,644 --> 00:24:38,910
That would have shown up on the scans.
514
00:24:39,012 --> 00:24:40,012
His chest looks normal.
515
00:24:45,930 --> 00:24:47,130
Maybe we can't think of the answer
516
00:24:47,198 --> 00:24:48,397
because there is no answer.
517
00:24:48,466 --> 00:24:50,432
We keep trying to jam it into
these categories we know,
518
00:24:50,501 --> 00:24:51,500
the diseases that we know.
519
00:24:51,602 --> 00:24:54,170
But this never existed before.
520
00:24:54,239 --> 00:24:56,072
He created a new
combination of genetic code.
521
00:24:56,141 --> 00:24:57,873
That means a new
combination of symptoms.
522
00:24:57,908 --> 00:25:00,042
So, we shouldn't be
looking at what fits the picture,
523
00:25:00,111 --> 00:25:01,678
but at what's closest to the picture,
524
00:25:01,746 --> 00:25:03,479
so we can at least
figure out a treatment.
525
00:25:03,547 --> 00:25:07,216
And what it's closest to is amyloidosis.
526
00:25:07,791 --> 00:25:10,224
This isn't an autoimmune neuropathy,
527
00:25:10,260 --> 00:25:12,527
so the nerves must be under
attack by something else.
528
00:25:12,596 --> 00:25:14,563
Something like amyloid
disease could leave deposits
529
00:25:14,631 --> 00:25:17,232
along the nerves, causing
the symptoms we've seen.
530
00:25:17,301 --> 00:25:19,066
Where do we look for those deposits?
531
00:25:19,168 --> 00:25:21,035
The spleen.
532
00:25:28,097 --> 00:25:29,529
Drink all 8 ounces.
533
00:25:29,632 --> 00:25:32,532
We talked. We had a few laughs.
534
00:25:32,635 --> 00:25:34,334
Well, sounds date-y to me.
535
00:25:35,437 --> 00:25:37,104
I don't think Enrique's a player.
536
00:25:37,173 --> 00:25:38,572
No, he's kind of the
opposite of a player.
537
00:25:38,641 --> 00:25:41,041
With him, emotional
connection is the point.
538
00:25:41,110 --> 00:25:43,143
He's trying to live
some idealistic fantasy
539
00:25:43,212 --> 00:25:45,045
where everyone is nice
and no one is jealous.
540
00:25:45,114 --> 00:25:46,547
I am so staying away.
541
00:25:46,649 --> 00:25:47,748
Well, of course.
542
00:25:47,817 --> 00:25:48,916
Once I heard "emotional connection,"
543
00:25:49,018 --> 00:25:50,651
I knew the game was over.
544
00:25:50,720 --> 00:25:51,985
What does that mean?
545
00:25:52,087 --> 00:25:53,721
I'm against emotion?
546
00:25:53,756 --> 00:25:55,790
I'm not the one with
"cold-hearted bitch"
547
00:25:55,892 --> 00:25:57,458
as my social media hashtag.
548
00:25:57,527 --> 00:25:58,626
She's an excellent doctor.
549
00:25:58,728 --> 00:26:00,060
Every time you've loved somebody,
550
00:26:00,129 --> 00:26:01,996
it's ended in disappointment or death...
551
00:26:02,097 --> 00:26:03,063
sometimes both.
552
00:26:03,806 --> 00:26:05,038
It's like a reflex now.
553
00:26:05,108 --> 00:26:08,041
You just expect that everything
ends badly, so why start?
554
00:26:08,111 --> 00:26:11,378
So, despite the many
practical reasons not to go out
555
00:26:11,447 --> 00:26:13,347
with a first-year, this is all about me?
556
00:26:13,416 --> 00:26:16,850
Is that a diamond ring?
557
00:26:16,919 --> 00:26:18,018
I mean, it's pretty.
558
00:26:18,120 --> 00:26:19,620
Our patient caught her fianc� cheating.
559
00:26:19,688 --> 00:26:21,622
Big fight. He demanded the ring back.
560
00:26:21,724 --> 00:26:22,990
She swallowed it.
561
00:26:23,058 --> 00:26:24,157
I did.
562
00:26:24,226 --> 00:26:25,393
You don't even know
if this is "going out,"
563
00:26:25,461 --> 00:26:26,694
and that's the point.
564
00:26:27,338 --> 00:26:29,172
It doesn't matter what
Enrique's offering.
565
00:26:29,240 --> 00:26:31,475
Whether it's friendship or
romance, you're not investing.
566
00:26:31,577 --> 00:26:32,676
You're risk-averse.
567
00:26:32,778 --> 00:26:33,809
Your portfolio right now
568
00:26:33,879 --> 00:26:35,812
is entirely in T-Bills and money market.
569
00:26:35,881 --> 00:26:37,046
I have no idea what that means.
570
00:26:37,115 --> 00:26:38,715
And it's too bad, because a
guy that can make you laugh
571
00:26:38,784 --> 00:26:40,617
might be just what you need right now.
572
00:26:41,630 --> 00:26:43,426
It's progressed to your large intestine.
573
00:26:43,589 --> 00:26:45,856
Here's a plastic bag.
Put it over the toilet seat.
574
00:26:45,925 --> 00:26:47,992
You'll have every opportunity
to recover your property.
575
00:26:52,064 --> 00:26:55,098
Don't run away from a chance at love.
576
00:26:55,167 --> 00:26:58,235
It's a date...
577
00:26:58,337 --> 00:26:59,237
maybe.
578
00:26:59,339 --> 00:27:00,238
I don't know.
579
00:27:03,609 --> 00:27:05,442
Her house is full of T.C.E....
580
00:27:05,511 --> 00:27:06,643
a side effect from chip-making
581
00:27:06,712 --> 00:27:08,512
back in Silicon Valley's early days.
582
00:27:08,615 --> 00:27:10,447
So, they move away
from their toxic home,
583
00:27:10,516 --> 00:27:11,882
and hopefully things
get a little better.
584
00:27:11,985 --> 00:27:13,184
Probably not much.
585
00:27:13,252 --> 00:27:15,119
She also has a genetic predisposition.
586
00:27:15,221 --> 00:27:16,920
It's both?
587
00:27:16,989 --> 00:27:18,755
She shouldn't go outside in a rainstorm.
588
00:27:20,259 --> 00:27:21,926
How do you tell a woman
that her third cancer
589
00:27:22,028 --> 00:27:23,761
likely won't be close to her last?
590
00:27:26,799 --> 00:27:29,266
Unfortunately, this
is a teaching moment.
591
00:27:32,607 --> 00:27:35,074
Dr. Allen, after 12 hours on duty,
592
00:27:35,143 --> 00:27:37,744
I can report that your
inserts came through.
593
00:27:37,846 --> 00:27:40,079
Check your e-mail.
You'll find my testimonial.
594
00:27:41,182 --> 00:27:42,115
Claire. Olivia.
595
00:27:49,658 --> 00:27:52,759
And if you're right, what will you do?
596
00:27:52,828 --> 00:27:55,294
We'll treat the symptoms
with targeted drug therapies.
597
00:27:55,363 --> 00:27:57,897
There really isn't a disease,
as such, that we can address.
598
00:28:05,932 --> 00:28:06,865
The pain shifted?
599
00:28:06,967 --> 00:28:07,966
Yeah.
600
00:28:09,269 --> 00:28:10,436
Never mind about the ultrasound.
601
00:28:10,538 --> 00:28:11,803
It'll be easier to check for deposits
602
00:28:11,905 --> 00:28:12,871
after the organ's been removed.
603
00:28:12,973 --> 00:28:14,205
- After it's...
- Yeah.
604
00:28:14,308 --> 00:28:16,141
His spleen's about to
rupture. Call a transport team.
605
00:28:27,607 --> 00:28:30,656
It's called Li-Fraumeni Syndrome... LFS.
606
00:28:30,876 --> 00:28:32,242
An inherited predisposition
607
00:28:32,414 --> 00:28:33,904
to developing a wide range of cancers.
608
00:28:35,060 --> 00:28:36,860
Yes, there was a toxin
in your environment
609
00:28:36,962 --> 00:28:38,495
that likely played a role in this,
610
00:28:38,564 --> 00:28:40,630
but there will be other
triggers in the future.
611
00:28:40,699 --> 00:28:42,766
Your body is super sensitive
612
00:28:42,801 --> 00:28:45,368
and will respond with
tumors for the rest of your life.
613
00:28:53,422 --> 00:28:56,023
I know that's a shock,
614
00:28:56,091 --> 00:28:58,425
but here's what you should know...
615
00:28:58,527 --> 00:29:02,062
most cancers are treatable
if found early enough.
616
00:29:05,200 --> 00:29:07,968
We know the most
common associated with LFS,
617
00:29:08,070 --> 00:29:10,103
and we can do surveillance...
618
00:29:10,171 --> 00:29:14,941
nip anything in the bud
before it becomes a problem.
619
00:29:15,010 --> 00:29:19,045
It may not seem this
way now, but this is good.
620
00:29:19,147 --> 00:29:21,014
We know what we're dealing with.
621
00:29:21,082 --> 00:29:23,950
We're warned, and we'll be ready.
622
00:29:32,941 --> 00:29:35,041
He won't be able to handle this.
623
00:29:39,615 --> 00:29:42,449
Liver, pancreas...
other organs look normal.
624
00:29:43,819 --> 00:29:46,753
But there are calcified
lesions along these nerves.
625
00:29:46,822 --> 00:29:48,755
He's gonna be in pain like
this for the rest of his life.
626
00:29:48,857 --> 00:29:49,956
No.
627
00:29:50,025 --> 00:29:51,958
There's a reasonable
chance it'll get worse
628
00:29:52,060 --> 00:29:53,326
as time goes on.
629
00:29:53,394 --> 00:29:55,328
I need my sharp-blunt curved scissors.
630
00:29:55,430 --> 00:29:57,697
What if we used
CRISPR to reverse CRISPR?
631
00:30:00,051 --> 00:30:02,752
Researchers have identified
a protein in certain bacteria
632
00:30:02,854 --> 00:30:04,688
that inhibits CRISPR.
633
00:30:04,756 --> 00:30:06,989
What if we insert the DNA
that makes that protein
634
00:30:07,058 --> 00:30:08,291
into our patient's genome?
635
00:30:08,359 --> 00:30:10,126
That would deactivate the CRISPR gene.
636
00:30:10,228 --> 00:30:11,460
So, CRISPR
messed him up permanently,
637
00:30:11,563 --> 00:30:13,162
and you think we should do more of it?
638
00:30:13,231 --> 00:30:14,898
I don't know. Our
patient is a risk-taker.
639
00:30:14,966 --> 00:30:16,533
We'd need a delivery mechanism.
640
00:30:16,601 --> 00:30:18,768
The code would have to be
introduced through a virus...
641
00:30:18,870 --> 00:30:21,804
a virus that specifically
targets nerves.
642
00:30:24,068 --> 00:30:25,634
Polio targets nerves.
643
00:30:25,703 --> 00:30:27,536
Because this isn't risky enough.
644
00:30:27,605 --> 00:30:28,971
Polio is such a dangerous virus
645
00:30:29,040 --> 00:30:31,307
because it's so good at
penetrating the nervous system.
646
00:30:35,152 --> 00:30:37,093
_
647
00:30:38,516 --> 00:30:42,116
_
648
00:30:43,420 --> 00:30:44,635
_
649
00:30:44,714 --> 00:30:45,806
_
650
00:30:49,717 --> 00:30:50,950
Dr. Murphy?
651
00:30:54,989 --> 00:30:59,826
She's going to be this way... forever.
652
00:30:59,894 --> 00:31:02,695
She'll have good
periods and bad periods.
653
00:31:02,764 --> 00:31:06,299
But she will always
have to be on her guard.
654
00:31:06,367 --> 00:31:10,174
Is she always gonna have to
be on guard against you, too?
655
00:31:11,163 --> 00:31:12,296
What does that mean?
656
00:31:12,365 --> 00:31:14,531
Chronic illness puts
strain on relationships.
657
00:31:14,599 --> 00:31:18,035
Statistically, it is more often
the man who can't handle it.
658
00:31:18,103 --> 00:31:20,236
Our marriage is none of your business.
659
00:31:20,338 --> 00:31:22,005
Her health is my business.
660
00:31:22,074 --> 00:31:23,940
And your behavior adds to her stress.
661
00:31:26,111 --> 00:31:30,213
You look at her, and you imagine
she's gone, and that is hard.
662
00:31:30,316 --> 00:31:31,515
I get it.
663
00:31:34,213 --> 00:31:37,714
She thinks the same thing
when she looks at you.
664
00:31:37,783 --> 00:31:40,617
I never complain to her.
I know it's nobody's fault.
665
00:31:40,686 --> 00:31:43,187
You don't think she knows
you have trouble with all this?
666
00:31:43,255 --> 00:31:45,589
Every time something new happens,
667
00:31:45,657 --> 00:31:48,324
she wonders, is this the straw
668
00:31:48,394 --> 00:31:51,661
that is gonna break your marriage?
669
00:31:51,730 --> 00:31:54,197
You've got her living in a
constant state of uncertainty.
670
00:31:54,266 --> 00:31:57,801
That is practically
the definition of stress.
671
00:31:58,894 --> 00:32:02,895
So, this is the "straighten
up and fly right" lecture.
672
00:32:02,998 --> 00:32:04,096
No.
673
00:32:06,001 --> 00:32:08,668
I am...
674
00:32:08,737 --> 00:32:13,640
I'm telling you to consider
how best to time your divorce.
675
00:32:14,943 --> 00:32:17,744
There are gonna be a lot of
new issues dropping on Hannah,
676
00:32:17,846 --> 00:32:19,612
and if you're gonna
end up leaving anyway,
677
00:32:19,681 --> 00:32:20,913
you should start planning now.
678
00:32:21,016 --> 00:32:22,181
I don't want to leave my wife.
679
00:32:22,283 --> 00:32:24,784
My best advice?
680
00:32:24,853 --> 00:32:28,955
Help her through this next round
of treatment as best you can,
681
00:32:29,058 --> 00:32:31,691
and then get out.
682
00:32:31,793 --> 00:32:35,128
It's hard living with
someone who needs so much.
683
00:32:35,197 --> 00:32:39,032
I know you feel there is a point
where you have nothing left,
684
00:32:39,134 --> 00:32:42,168
where you're ready to break.
685
00:32:42,271 --> 00:32:47,274
Just... don't break when
she needs you most.
686
00:32:48,744 --> 00:32:50,743
Get out before that happens.
687
00:33:11,402 --> 00:33:13,503
Reading an article
that's five years old?
688
00:33:13,571 --> 00:33:16,238
Dr. Glassman was once
involved in an experimental attempt
689
00:33:16,307 --> 00:33:19,041
to treat Parkinson's
with CRISPR technology.
690
00:33:19,143 --> 00:33:20,142
It failed.
691
00:33:20,177 --> 00:33:21,911
So, it's both old and it didn't work?
692
00:33:21,979 --> 00:33:24,479
Dr. Glassman likes his
failures to be informative.
693
00:33:24,548 --> 00:33:26,415
That's why his articles are longer.
694
00:33:26,484 --> 00:33:29,284
Do you worry about
losing the people you love?
695
00:33:35,473 --> 00:33:38,074
Because we can't stop
ourselves from changing,
696
00:33:38,143 --> 00:33:40,310
which means we might
stop loving someone,
697
00:33:40,412 --> 00:33:41,778
or they might stop loving us.
698
00:33:41,847 --> 00:33:44,113
It is a very bad thing.
699
00:33:44,215 --> 00:33:45,648
It is.
700
00:33:48,620 --> 00:33:52,721
So, no one can ever feel... safe.
701
00:33:52,757 --> 00:33:56,592
How can you keep going
if you never feel safe?
702
00:34:01,942 --> 00:34:04,542
Well, sometimes, not
changing is just as dangerous.
703
00:34:07,414 --> 00:34:11,450
So, how do you know when to do what?
704
00:34:13,187 --> 00:34:15,320
If you find the answer
to that, let me know.
705
00:34:22,538 --> 00:34:24,238
- I have it.
- You do?
706
00:34:24,307 --> 00:34:27,108
Dr. Glassman used varicella zoster virus
707
00:34:27,176 --> 00:34:29,877
as the delivery mechanism,
which didn't work.
708
00:34:29,946 --> 00:34:31,913
His first choice was herpes simplex,
709
00:34:31,981 --> 00:34:33,514
but the technology was not up
710
00:34:33,582 --> 00:34:35,283
to putting their DNA package into it.
711
00:34:35,384 --> 00:34:37,585
The technology has improved.
712
00:34:37,787 --> 00:34:39,987
It can be done.
713
00:34:45,654 --> 00:34:47,186
Using conventional treatments,
714
00:34:47,289 --> 00:34:48,822
there's nothing more we can do for you.
715
00:34:48,890 --> 00:34:51,658
The pain will be permanent,
and it could get worse.
716
00:34:52,961 --> 00:34:57,664
Well, I've not been one to
be limited by the conventional.
717
00:34:57,732 --> 00:34:59,799
We think we can reverse the CRISPR.
718
00:34:59,869 --> 00:35:03,133
You want to reverse what I
did? My telomerase change?
719
00:35:03,295 --> 00:35:03,965
They want to stop your pain.
720
00:35:04,068 --> 00:35:05,835
Soph, it's temporary.
721
00:35:05,937 --> 00:35:07,403
What is it, 40 years?
722
00:35:07,471 --> 00:35:10,862
That's nothing. Our real
lives are ahead of us.
723
00:35:11,062 --> 00:35:13,295
Hey, look, as long
as this doesn't kill me,
724
00:35:13,363 --> 00:35:16,464
I've made the right choice,
no matter how bad things get.
725
00:35:16,566 --> 00:35:17,332
No.
726
00:35:18,869 --> 00:35:23,838
I was willing to exercise
for hours and fast,
727
00:35:23,907 --> 00:35:26,107
to give up all sugar and alcohol
728
00:35:26,209 --> 00:35:28,576
and do all the other
things that we needed to do
729
00:35:28,645 --> 00:35:33,515
to get to a future that I
knew might never come.
730
00:35:33,583 --> 00:35:37,652
But now, you're asking
me to watch you suffer
731
00:35:37,721 --> 00:35:39,420
for the rest of your life.
732
00:35:49,011 --> 00:35:53,415
You're the one who embraces change.
733
00:35:53,483 --> 00:35:58,753
So, change to the person
who can be happy with me...
734
00:35:58,855 --> 00:36:00,755
here and now.
735
00:36:09,065 --> 00:36:11,399
Doctors, would you mind waiting outside?
736
00:36:18,766 --> 00:36:21,767
Why did she want us to leave?
737
00:36:21,835 --> 00:36:23,669
I think she's delivering an ultimatum.
738
00:36:36,410 --> 00:36:37,908
Are you sure about this?
739
00:36:39,445 --> 00:36:41,980
It seems there's always something else
740
00:36:41,982 --> 00:36:43,615
that I have to give up.
741
00:36:45,952 --> 00:36:48,073
But this isn't like sugar or cigarettes.
742
00:36:48,309 --> 00:36:50,676
You won't get over this in a hurry.
743
00:36:50,778 --> 00:36:52,812
No.
744
00:36:52,914 --> 00:36:54,446
Not in 1,000 years.
745
00:37:05,127 --> 00:37:05,958
Are you gonna be okay?
746
00:37:06,803 --> 00:37:07,875
I'm fine.
747
00:37:08,075 --> 00:37:10,129
Alan's at work, but there
should be a taxi waiting.
748
00:37:11,235 --> 00:37:12,798
I won't say goodbye, Dr. Browne,
749
00:37:12,867 --> 00:37:16,368
'cause I'll probably be
seeing you again pretty soon.
750
00:37:20,277 --> 00:37:21,841
I sent your cab away.
751
00:37:23,123 --> 00:37:24,376
I'm sorry I wasn't here sooner.
752
00:37:25,950 --> 00:37:27,947
I had to present a
proposal to my partners.
753
00:37:36,973 --> 00:37:38,607
I'm selling them my
share of the business.
754
00:37:43,170 --> 00:37:44,679
Is... Is there something
else you want to do?
755
00:37:47,418 --> 00:37:48,234
Yes.
756
00:37:50,667 --> 00:37:52,410
I want to be your husband.
757
00:37:59,393 --> 00:38:03,029
I realized I was so...
758
00:38:03,097 --> 00:38:08,300
afraid of losing you in the future...
759
00:38:08,369 --> 00:38:09,635
I was losing you now.
760
00:38:38,376 --> 00:38:39,742
Sorry.
761
00:38:39,811 --> 00:38:42,445
I hear your VC contact
decided to quit the business.
762
00:38:44,950 --> 00:38:46,482
He did the right thing.
763
00:38:53,458 --> 00:38:56,159
You know...
764
00:38:56,227 --> 00:38:58,828
my feet are killing me.
765
00:39:21,890 --> 00:39:24,791
I'm open. To being friends.
766
00:39:24,893 --> 00:39:25,958
That's great.
767
00:39:26,060 --> 00:39:29,295
I'm open, too, to wherever this goes.
768
00:39:29,331 --> 00:39:31,697
It's going to friendship.
769
00:39:31,766 --> 00:39:33,566
Understood.
770
00:39:33,635 --> 00:39:34,867
But life is about change,
771
00:39:34,936 --> 00:39:36,469
which means, one day,
you might change your mind.
772
00:39:36,538 --> 00:39:38,872
And if you did, I'd
be open to that, too.
773
00:39:38,974 --> 00:39:40,407
It's not gonna happen.
774
00:39:43,876 --> 00:39:45,234
Okay.
775
00:40:05,390 --> 00:40:07,556
First, there should be no soap involved.
776
00:40:07,625 --> 00:40:09,392
Also, we need to stay
at one end of the shower,
777
00:40:09,461 --> 00:40:12,662
so we don't accidentally knock
into the temperature control.
778
00:40:13,567 --> 00:40:16,134
What changed your mind?
779
00:40:16,236 --> 00:40:19,070
I've been thinking
about change over time.
780
00:40:19,172 --> 00:40:20,939
I spoke with people and also graphed
781
00:40:21,007 --> 00:40:22,473
several possibilities for us,
782
00:40:22,543 --> 00:40:24,242
using time as the horizontal axis
783
00:40:24,311 --> 00:40:25,476
and change as the vertical.
784
00:40:25,546 --> 00:40:28,547
I realized that the
problem isn't really change.
785
00:40:28,582 --> 00:40:32,583
It's whether two people
change in the same direction.
786
00:40:32,652 --> 00:40:34,786
We want to keep our
coordinates close to each other
787
00:40:34,888 --> 00:40:37,589
for the rest of our lives.
788
00:40:37,658 --> 00:40:40,358
We certainly do.
789
00:40:40,427 --> 00:40:43,494
But people sometimes do drift apart.
790
00:40:44,378 --> 00:40:44,695
Yes.
791
00:40:44,765 --> 00:40:46,865
You need a warning
when you and your partner
792
00:40:47,630 --> 00:40:48,962
might be starting to veer off,
793
00:40:49,031 --> 00:40:50,631
so you can both change course a little.
794
00:40:50,699 --> 00:40:52,799
You don't want a surprise
realization when it's too late.
795
00:40:52,901 --> 00:40:54,200
Surprises are awful.
796
00:40:54,236 --> 00:40:57,237
The U.S. Army Signal Corps
used flags to warn of hurricanes.
797
00:40:57,339 --> 00:40:59,205
I brought us this.
798
00:41:00,805 --> 00:41:02,009
A cowbell?
799
00:41:02,660 --> 00:41:05,661
If you see us heading
in different directions,
800
00:41:05,763 --> 00:41:06,896
you ring it.
801
00:41:06,964 --> 00:41:09,399
Do we really need a
bell? Can't I just tell you?
802
00:41:10,602 --> 00:41:12,735
Oh! When you ring
it, I'll pay attention.
803
00:41:12,837 --> 00:41:14,237
I really hate the sound.
804
00:41:14,305 --> 00:41:17,640
Only in emergencies.
805
00:41:17,709 --> 00:41:22,111
I've already moved the shampoo bottles.
806
00:41:22,213 --> 00:41:23,279
What?
807
00:41:26,985 --> 00:41:28,651
You mean now?
808
00:41:32,803 --> 00:41:34,970
Don't worry about
putting the bottles back.
809
00:41:35,072 --> 00:41:36,004
I'll do it later.
810
00:41:37,141 --> 00:41:39,207
I love you.
811
00:41:39,309 --> 00:41:41,876
It's no trouble. I remember
where they all go.
59965
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